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Cluster headache

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https://www.readbyqxmd.com/read/28094022/a-case-report-of-an-adolescent-with-cluster-headaches-following-neck-trauma-coincidence-or-trigger
#1
Agnieszka Biedroń, Marek Kaciński, Małgorzata Steczkowska, Anna Świerczyńska
Posttraumatic headaches usually have tension-type or migraine-like characteristics. A correlation between head trauma and cluster headaches (CH) has been previously reported. CH in children are rare and require thorough differential diagnosis. We present an original case of a 15-year-old boy with cluster headaches associated with allodynia probably evoked by a neck trauma. Severe headache attacks started one month after neck trauma. At the beginning clinical presentation of our patient's headaches was very misleading...
January 10, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28074859/identifying-a-gene-expression-signature-of-cluster-headache-in-blood
#2
Else Eising, Nadine Pelzer, Lisanne S Vijfhuizen, Boukje de Vries, Michel D Ferrari, Peter A C 't Hoen, Gisela M Terwindt, Arn M J M van den Maagdenberg
Cluster headache is a relatively rare headache disorder, typically characterized by multiple daily, short-lasting attacks of excruciating, unilateral (peri-)orbital or temporal pain associated with autonomic symptoms and restlessness. To better understand the pathophysiology of cluster headache, we used RNA sequencing to identify differentially expressed genes and pathways in whole blood of patients with episodic (n = 19) or chronic (n = 20) cluster headache in comparison with headache-free controls (n = 20)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28034970/cardiovascular-risk-factors-in-cluster-headache
#3
S Santos Lasaosa, E Bellosta Diago, J Navarro Calzada, A Velázquez Benito
BACKGROUND:  Patients with cluster headache tend to have a dysregulation of systemic blood pressure such as increased blood pressure variability and decreased nocturnal dipping. This pattern of nocturnal nondipping is associated with end-organ damage and increased risk of cardiovascular disease. OBJECTIVE:  To determine if cluster headache is associated with a higher risk of cardiovascular disease. METHODS:  Cross-sectional study of 33 cluster headache patients without evidence of cardiovascular disease and 30 age- and gender-matched healthy controls...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28028803/cortical-alterations-in-medication-overuse-headache
#4
Franz Riederer, Marie Schaer, Andreas R Gantenbein, Roger Luechinger, Lars Michels, Marihan Kaya, Spyridon Kollias, Peter S Sándor
OBJECTIVE: Using surface-based morphometry we aimed to provide a detailed examination of cortical alterations in medication-overuse headache (MOH), by disentangling between altered cortical thickness and gyrification (folding). BACKGROUND: In MOH, pain modulation is probably dysfunctional at the cortical and subcortical level, resulting in a disequilibrium between pain inhibition and facilitation. Both increased and decreased cortical volumes have been reported in individuals with MOH...
December 28, 2016: Headache
https://www.readbyqxmd.com/read/28017403/efficacy-and-effectiveness-of-an-rvsv-vectored-vaccine-in-preventing-ebola-virus-disease-final-results-from-the-guinea-ring-vaccination-open-label-cluster-randomised-trial-ebola-%C3%A3-a-suffit
#5
Ana Maria Henao-Restrepo, Anton Camacho, Ira M Longini, Conall H Watson, W John Edmunds, Matthias Egger, Miles W Carroll, Natalie E Dean, Ibrahima Diatta, Moussa Doumbia, Bertrand Draguez, Sophie Duraffour, Godwin Enwere, Rebecca Grais, Stephan Gunther, Pierre-Stéphane Gsell, Stefanie Hossmann, Sara Viksmoen Watle, Mandy Kader Kondé, Sakoba Kéïta, Souleymane Kone, Eewa Kuisma, Myron M Levine, Sema Mandal, Thomas Mauget, Gunnstein Norheim, Ximena Riveros, Aboubacar Soumah, Sven Trelle, Andrea S Vicari, John-Arne Røttingen, Marie-Paule Kieny
BACKGROUND: rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested the effect of rVSV-ZEBOV in preventing Ebola virus disease in contacts and contacts of contacts of recently confirmed cases in Guinea, west Africa. METHODS: We did an open-label, cluster-randomised ring vaccination trial (Ebola ça Suffit!) in the communities of Conakry and eight surrounding prefectures in the Basse-Guinée region of Guinea, and in Tomkolili and Bombali in Sierra Leone...
December 23, 2016: Lancet
https://www.readbyqxmd.com/read/27995704/treatment-of-intractable-chronic-cluster-headache-by-occipital-nerve-stimulation-a-cohort-of-51-patients
#6
S Miller, L Watkins, M Matharu
BACKGROUND AND PURPOSE: Chronic cluster headache is a rare, highly disabling primary headache condition. When medically intractable, occipital nerve stimulation can offer effective treatment. Open-label series have provided data on small cohorts only. METHODS: We analyzed 51 subjects to evaluate the long-term outcomes of highly intractable chronic cluster headache with occipital nerve stimulation. Patients with intractable chronic cluster headache were implanted with occipital nerve stimulators during the period 2007-2014...
February 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27957625/a-genome-wide-analysis-in-cluster-headache-points-to-neprilysin-and-pacap-receptor-gene-variants
#7
Elena Bacchelli, Maria Michela Cainazzo, Cinzia Cameli, Simona Guerzoni, Angela Martinelli, Michele Zoli, Elena Maestrini, Luigi Alberto Pini
BACKGROUND: Cluster Headache (CH) is a severe primary headache, with a poorly understood pathophysiology. Complex genetic factors are likely to play a role in CH etiology; however, no confirmed gene associations have been identified. The aim of this study is to identify genetic variants influencing risk to CH and to explore the potential pathogenic mechanisms. METHODS: We have performed a genome-wide association study (GWAS) in a clinically well-defined cohort of 99 Italian patients with CH and in a control sample of 360 age-matched sigarette smoking healthy individuals, using the Infinium PsychArray (Illumina), which combines common highly-informative genome-wide tag SNPs and exonic SNPs...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27940880/cgrp-in-human-models-of-primary-headaches
#8
Håkan Ashina, Henrik Winther Schytz, Messoud Ashina
OBJECTIVE: To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. DISCUSSION: Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown...
December 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27929328/association-of-posttraumatic-stress-disorder-symptoms-with-migraine-and-headache-after-a-natural-disaster
#9
Mariana C Arcaya, Sarah R Lowe, Asad L Asad, S V Subramanian, Mary C Waters, Jean Rhodes
OBJECTIVE: Previous research shows that migraine and general headache symptoms increase after traumatic events. Questions remain about whether posttraumatic stress disorder (PTSD) produces migraine/headache symptoms, or if individuals afflicted by migraine/headache are especially likely to develop PTSD. We test whether PTSD symptoms following a natural disaster are associated with higher odds of reporting frequent headaches/migraines postdisaster. We decompose PTSD into intrusion, avoidance, and hyperarousal symptom clusters to examine which, if any, are uniquely related to headache/migraine postdisaster...
December 8, 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/27925184/a-case-report-about-cluster-tic-syndrome-due-to-venous-compression-of-the-trigeminal-nerve
#10
Ilse de Coo, J Marc C van Dijk, Jan D M Metzemaekers, Joost Haan
BACKGROUND: The term "cluster-tic syndrome" is used for the rare ipsilateral co-occurrence of attacks of cluster headache and trigeminal neuralgia. Medical treatment should combine treatment for cluster headache and trigeminal neuralgia, but is very often unsatisfactory. CASE: Here, we describe a 41-year-old woman diagnosed with cluster-tic syndrome who underwent microvascular decompression of the trigeminal nerve, primarily aimed at the "trigeminal neuralgia" part of her pain syndrome...
December 7, 2016: Headache
https://www.readbyqxmd.com/read/27924713/acetylcholinesterase-and-neuropathy-target-esterase-activities-in-11-cases-of-symptomatic-flight-crew-members-after-fume-events
#11
Astrid R R Heutelbeck, Catherine Bornemann, Martina Lange, Anke Seeckts, Michael M Müller
In modern aviation, so-called fume events such as exposure to an unknown mixture of chemicals introduced into the aircraft cabin with bleed air drawn off at the engines may occur. Human exposure may result in (neuro)toxic symptoms described as so-called "aerotoxic syndrome." Currently, among other agents organophosphates (OP) are regarded as a likely cause of the observed adverse effects. After fume events 11 flight crew members (9 female/2 male; ages 23-58 yr) were admitted for a medical examination within 5 d post exposure...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27924616/the-prevalence-of-primary-headache-disorders-in-ethiopia
#12
Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K Worku, Hallie Thomas, Timothy J Steiner
BACKGROUND: Knowledge of the epidemiology of primary headache disorders in sub-Saharan Africa (SSA) remains very limited. We performed a population-based survey in rural and urban areas of Ethiopia, using methods similar to those of an earlier study in Zambia and tested in multiple other countries by Lifting The Burden. METHODS: In a cross-sectional survey we visited households unannounced in four regions of Ethiopia: the mostly urban populations in Addis Ababa and its environs and rural populations of selected districts in Oromia, Amhara and South Nations Nationalities and People's Regions States (SNNPRS)...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27910088/the-efficacy-of-greater-occipital-nerve-blockade-in-chronic-migraine-a-placebo-controlled-study
#13
H L Gul, A O Ozon, O Karadas, G Koc, L E Inan
OBJECTIVE: GON blockade with local anesthetics is an effective treatment for a group of headaches, such as cervicogenic headache, cluster headache, occipital neuralgia, migraine. Our aim was to evaluate the efficacy of greater occipital nerve (GON) blockade in patients with chronic migraine (CM) by using a control group. MATERIALS AND METHODS: We included 44 CM patients and randomly divide the patients into two groups, as group A (bupivacaine) and group B (placebo) to our study...
December 2, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27861832/cluster-headache-with-accompanying-migraine-like-features-a-possible-clinical-phenotype
#14
Arens Taga, Marco Russo, Gian Camillo Manzoni, Paola Torelli
BACKGROUND: There are limited literature data on migraine-like accompanying features (MLF) in patients with cluster headache (CH). These symptoms are frequently reported by patients and may delay CH diagnosis. OBJECTIVE: The aim of the present study was to investigate the occurrence of migraine-like symptoms in an Italian case series of CH patients and to determine whether these features influence the clinical phenotype of CH. METHODS: A cross-sectional study was performed in all consecutive patients referred to the Parma Headache Centre between 1975 and 2013 affected by CH; the cases were subsequently reviewed applying the ICHD3-beta criteria...
November 10, 2016: Headache
https://www.readbyqxmd.com/read/27861830/hemicrania-continua-beneficial-effect-of-non-invasive-vagus-nerve-stimulation-in-a-patient-with-a-contraindication-for-indomethacin
#15
Ozan Eren, Andreas Straube, Florian Schöberl, Christoph Schankin
Hemicrania continua (HC) is a primary chronic headache disorder, characterized by a continuous and strictly unilateral headache, with possible cranial autonomic symptoms during episodes of pain exacerbation. The unilateral headache generally responds well to indomethacin; however, continuous indomethacin intake is often not tolerated due to severe adverse effects, like hypertension, gastrointestinal discomfort (especially if combined with aspirin), slightly increased risk of vascular events, and bronchial spasms...
November 11, 2016: Headache
https://www.readbyqxmd.com/read/27860050/characterization-of-hangover-following-intravenous-alcohol-exposure-in-social-drinkers-methodological-and-clinical-implications
#16
Vatsalya Vatsalya, Bethany L Stangl, Veronica Y Schmidt, Vijay A Ramchandani
Hangover refers to the cluster of physiological and behavioral symptoms that occur following the end of a drinking episode. While hangover has been studied after the typical oral consumption of alcohol, the occurrence of hangover following intravenous (IV) alcohol administration in human laboratory studies has not been previously reported. This study characterizes hangover symptoms and post-infusion drinking behavior following acute IV alcohol administration in social drinkers. Twenty-one to thirty-year-old healthy social drinkers (n = 24) underwent an alcohol clamp session at breath alcohol concentration of 0...
November 11, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27849273/use-of-prescription-drugs-and-self-medication-among-men
#17
Maria Aparecida Medeiros Barros do Prado, Priscila Maria Stolses Bergamo Francisco, Tássia Fraga Bastos, Marilisa Berti de Azevedo Barros
Objective: To estimate the prevalence, investigate factors associated with the use of medication according to prescription, identify the main pharmaceuticals consumed through self-medication, and the reason for this use among adult men. Methods: This cross-sectional population-based study with stratified clustered two-stage sampling was conducted in Campinas, São Paulo, Brazil, in 2008/2009. Results: Of the 1,063 men, 45.3% reported using at least 1 drug in the last 3 days...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/27834408/-headache-classification-and-diagnosis
#18
P A T Carbaat, E G M Couturier
There are many types of headache and, moreover, many people have different types of headache at the same time. Adequate treatment is possible only on the basis of the correct diagnosis. Technically and in terms of content the current diagnostics process for headache is based on the 'International Classification of Headache Disorders' (ICHD-3-beta) that was produced under the auspices of the International Headache Society. This classification is based on a distinction between primary and secondary headaches...
November 2016: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/27815646/ipsilateral-alteration-of-resting-state-activity-suggests-that-cortical-dysfunction-contributes-to-the-pathogenesis-of-cluster-headache
#19
Péter Faragó, Nikoletta Szabó, Eszter Tóth, Bernadett Tuka, András Király, Gergő Csete, Árpád Párdutz, Délia Szok, János Tajti, Csaba Ertsey, László Vécsei, Zsigmond Tamás Kincses
The pathomechanism of cluster headache (CH) is not entirely understood, but central and peripheral components were suggested. A recent report showed that transcranial magnetic stimulation measured cortical excitability was increased in the hemisphere ipsilalteral to the pain. In the current study we set out to investigate the amplitude of resting brain fMRI activity to find signatures of the increased excitability. High resolution T1 weighted and resting state functional MRI images were acquired from seventeen patients with CH in pain free period and from twenty-six healthy volunteers...
November 4, 2016: Brain Topography
https://www.readbyqxmd.com/read/27792856/review-of-familial-cerebral-cavernous-malformations-and-report-of-seven-additional-families
#20
REVIEW
Ivo J H M de Vos, Maaike Vreeburg, Ger H Koek, Maurice A M van Steensel
Cerebral cavernous malformations are vascular anomalies of the central nervous system characterized by clusters of enlarged, leaky capillaries. They are caused by loss-of-function mutations in KRIT1, CCM2, or PDCD10. The proteins encoded by these genes are involved in four partially interconnected signaling pathways that control angiogenesis and endothelial permeability. Cerebral cavernous malformations can occur sporadically, or as a familial autosomal dominant disorder (FCCM) with incomplete clinical and neuroradiological penetrance and great inter-individual variability...
February 2017: American Journal of Medical Genetics. Part A
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