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Cluster headache

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https://www.readbyqxmd.com/read/29754500/rare-primary-headaches-in-italian-tertiary-headache-centres-three-year-nationwide-retrospective-data-from-the-registrare-network
#1
Chiara Lupi, Luana Evangelista, Valentina Favoni, Antonio Granato, Andrea Negro, Lanfranco Pellesi, Raffaele Ornello, Antonio Russo, Sabina Cevoli, Simona Guerzoni, Silvia Benemei
Background Rare primary headaches are mainly included in Chapters 3, Trigeminal autonomic cephalalgias, and 4, Other primary headache disorders, Part One of the International Classification of Headache Disorders 3rd edition. Epidemiological data are scarce, mostly emerging from case series or small studies, with the exception of cluster headache. In order to overcome the knowledge gap about rare primary headaches, the RegistRare Network was launched in 2017 to promote research in the field. Methods A retrospective cohort study including patients who, from April 30, 2014 to May 1, 2017, visited seven Italian tertiary Headache Centres, was undertaken to estimate in that clinical setting prevalence and incidence of headaches included in Chapters 3 and 4, Part One of the International Classification of Headache Disorders 3rd edition...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29751998/does-somatostatin-have-a-role-to-play-in-migraine-headache
#2
REVIEW
Geoffrey A Lambert, Alessandro S Zagami
Migraine is a condition without apparent pathology. Its cardinal symptom is the prolonged excruciating headache. Theories about this pain have posited pathologies which run the gamut from neural to vascular to neurovascular, but no observations have detected a plausible pathology. We believe that no pathology can be found for migraine headache because none exists. Migraine is not driven by pathology - it is driven by neural events produced by triggers - or simply by neural noise- noise that has crossed a critical threshold...
April 17, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29720819/functional-neuroimaging-in-trigeminal-autonomic-cephalalgias
#3
REVIEW
Mark Obermann, Dagny Holle, Steffen Nagel
Functional neuroimaging was able to identify key structures for the pathophysiology of trigeminal autonomic cephalalgias (TACs) including cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing or cranial autonomic features and hemicrania continua. The posterior hypothalamus was the structure most consistently depicted with functional imaging in different states of disease with and without pain. Network-oriented imaging techniques such as resting-state functional resonance imaging were able to show a broader involvement of human trigeminal pain processing in the underlying pathophysiological mechanisms of the different TACs, highlighting similarities between this distinct group of primary headache disorders, while also demonstrating the differences in brain activation across these disorders...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29720818/classification-of-trigeminal-autonomic-cephalalgia-what-has-changed-in-international-classification-of-headache-disorders-3-beta
#4
REVIEW
K Ravishankar
The term "Trigeminal Autonomic Cephalalgia (TAC)" was first coined by Goadsby and Lipton[1] to include a group of relatively rare primary headache disorders characterized by moderate to severe, short-lived head pain in the trigeminal distribution with unilateral cranial parasympathetic autonomic features, such as lacrimation, rhinorrhea, conjunctival injection, eyelid edema, and ptosis. In the current International Classification of Headache Disorders (ICHD-3 beta),[2] the TAC group includes cluster headache (CH), paroxysmal hemicrania (PH), short-lasting unilateral neuralgiform headache attacks (SUNHAs) and their 2 subforms - SUNHAs with conjunctival injection and tearing (SUNCT), SUNHAs with cranial autonomic symptoms (SUNA)...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29720817/overview-of-trigeminal-autonomic-cephalalgias-nosologic-evolution-diagnosis-and-management
#5
REVIEW
Diana Yi-Ting Wei, Jonathan Jia Yuan Ong, Peter James Goadsby
The term trigeminal autonomic cephalalgias (TACs) encompasses four primary headache disorders - cluster headache, paroxysmal hemicrania (PH), hemicrania continua (HC), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)/short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA). All of these except HC are characterized by short-lasting headaches. HC is characterized by a continuous unilateral headache that waxes and wanes in its intensity without complete resolution...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29720815/hemicrania-continua
#6
REVIEW
Sanjay Prakash, Bansi Adroja
Hemicrania continua (HC) is an indomethacin responsive primary chronic headache disorder which is currently classified as a subtype of trigeminal autonomic cephalalgias (TACs). It is not very uncommon. There are >1000 cases of HC in the literature, and it constitutes 1.7% of total headache in the clinic settings. Misdiagnosis for HC is very common at all clinical settings. A diagnosis of HC is missed even by neurologists and headache specialists. It is characterized by a continuous strictly unilateral headache with superimposed exacerbations...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29720813/treatment-of-cluster-headache
#7
REVIEW
William S Kingston, David W Dodick
Cluster headache (CH) is a debilitating primary headache disorder. Although uncommon, affecting only 0.1% of population, it is one of the most painful conditions known to humankind. Three strategies are employed for effective treatment of CH, namely, abortive therapy, transitional therapy, and preventive therapy. Being an uncommon condition, there is a paucity of large-scale controlled trials and evidence of various therapies are based on smaller studies. This review primarily focuses on therapies with highest quality of evidence and also on the emerging therapies for CH...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29720812/cluster-headache-epidemiology-pathophysiology-clinical-features-and-diagnosis
#8
REVIEW
Diana Yi-Ting Wei, Jonathan Jia Yuan Ong, Peter James Goadsby
Cluster headache is a primary headache disorder affecting up to 0.1% of the population. Patients suffer from cluster headache attacks lasting from 15 to 180 min up to 8 times a day. The attacks are characterized by the severe unilateral pain mainly in the first division of the trigeminal nerve, with associated prominent unilateral cranial autonomic symptoms and a sense of agitation and restlessness during the attacks. The male-to-female ratio is approximately 2.5:1. Experimental, clinical, and neuroimaging studies have advanced our understanding of the pathogenesis of cluster headache...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29681827/hemicrania-continua-associated-with-classic-scintillating-scotoma
#9
Eva Auffenberg, Friedemann Bender, Tobias Freilinger
Hemicrania continua (HC) is a rare primary headache disorder, characterized by persistent unilateral pain associated with cranial autonomic symptoms and prompt response to indomethacin. While migrainous features (including aura) have been recognized in cluster headache, there have been only single reports of HC with aura. Here, we report the case of a 53-year-old man with constant right-sided headache and superimposed exacerbations to severe pain lasting for several hours. Secondary etiologies were excluded, and a diagnosis of HC was established after prompt and complete response to treatment with indomethacin...
January 2018: Case Reports in Neurology
https://www.readbyqxmd.com/read/29655843/trait-and-frequency-dependent-dysfunctional-habituation-to-trigeminal-nociceptive-stimulation-in-trigeminal-autonomic-cephalalgias
#10
Armando Perrotta, Gianluca Coppola, Maria Grazia Anastasio, Roberto De, Anna Ambrosini, Mariano Serrao, Vincenzo Parisi, Maurizio Evangelista, Giorgio Sandrini, Francesco Pierelli
We investigated whether the stimulation frequency, the pain phases and different diagnoses of trigeminal autonomic cephalalgias (TACs) may influence the habituation to pain. We studied the habituation of the nociceptive blink reflex (nBR) R2 responses at different stimulation frequencies (SF, 0.05, 0.1, 0.2, 0.3, 0.5, 1Hz), in 28 episodic cluster headache (ECH), 16 during (ECH-in) and 12 outside (ECH-out) the bout; they were compared with 16 episodic paroxysmal hemicrania (EPH) during the bout and 21 healthy subjects (HS)...
April 12, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29623198/cluster-headache-new-targets-and-options-for-treatment
#11
REVIEW
Patty Doesborg, Joost Haan
Cluster headache is a severe headache disorder with considerable impact on quality of life. The pathophysiology of the disease remains poorly understood. With few specific targets for treatment, current guidelines mainly include off-label treatment with medication. However, new targets for possible treatment options are emerging. Calcitonin gene-related peptide (CGRP)-targeted medication could become the first (cluster) headache-specific treatment option. Other exciting new treatment options include invasive and non-invasive neuromodulation techniques...
2018: F1000Research
https://www.readbyqxmd.com/read/29601305/noninvasive-neuromodulation-in-migraine-and-cluster-headache
#12
Amaal Starling
PURPOSE OF REVIEW: The purpose of this narrative review is to provide an overview of the currently available noninvasive neuromodulation devices for the treatment of migraine and cluster headache. RECENT FINDINGS: Over the last decade, several noninvasive devices have undergone development and clinical trials to evaluate efficacy and safety. Based on this body of work, single-pulse transcranial magnetic stimulation, transcutaneous supraorbital neurostimulation, and noninvasive vagal nerve stimulation devices have been cleared by the United States Food and Drug Administration and are available for clinical use for the treatment of primary headache disorders...
March 29, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29590422/veteran-experiences-seeking-non-pharmacologic-approaches-for-pain
#13
Karleen Giannitrapani, Matthew McCaa, Marie Haverfield, Robert D Kerns, Christine Timko, Steven Dobscha, Karl Lorenz
Introduction: Pain is a longstanding and growing concern among US military veterans. Although many individuals rely on medications, a growing body of literature supports the use of complementary non-pharmacologic approaches when treating pain. Our objective is to characterize veteran experiences with and barriers to accessing alternatives to medication (e.g., non-pharmacologic treatments or non-pharmacologic approaches) for pain in primary care. Materials and Methods: Data for this qualitative analysis were collected as part of the Effective Screening for Pain (ESP) study (2012-2017), a national randomized controlled trial of pain screening and assessment methods...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29590182/clinical-endpoints-in-the-controlled-human-challenge-model-for-shigella-a-call-for-standardization-and-the-development-of-a-disease-severity-score
#14
Chad K Porter, Amanda Lynen, Mark S Riddle, Kawsar Talaat, David Sack, Ramiro L Gutiérrez, Robin McKenzie, Barbara DeNearing, Brittany Feijoo, Robert W Kaminski, David N Taylor, Beth D Kirkpatrick, A Louis Bourgeois
BACKGROUND: Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve understanding of disease pathogenesis, describe clinical and immunologic responses to infection and as a tool for vaccine development. As the frequency and intent for use in vaccine comparisons increases, standardization of the primary endpoint definition is necessary. METHODS: Subject-level data were obtained from previously conducted experimental Shigella CHIM studies...
2018: PloS One
https://www.readbyqxmd.com/read/29556851/novel-interventional-nonopioid-therapies-in-headache-management
#15
REVIEW
Omar Viswanath, Roxanna Rasekhi, Rekhaben Suthar, Mark R Jones, Jacquelin Peck, Alan D Kaye
PURPOSE OF REVIEW: Headaches encompass a broad-based category of a symptom of pain in the region of the head or neck. For those patients who unfortunately do not obtain relief from conservative treatment, interventional techniques have been developed and are continuing to be refined in an attempt to treat this subset of patients with the goal of return of daily activities. This investigation reviews various categories of headaches, their pathophysiology, and types of interventional treatments currently available...
March 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29556828/treatment-of-the-patient-with-refractory-headache
#16
REVIEW
Alessandro S Zagami
PURPOSE OF REVIEW: To review recent studies outlining the management of refractory primary headache patients, including emerging therapies such as neuromodulation. This includes both noninvasive and invasive neuromodulation techniques. Recent studies on the management of medication overuse headache were also reviewed. RECENT FINDINGS: There is no consensus as yet on the definitions of refractory chronic migraine and chronic cluster headache although there is broad agreement on some aspects of these terms...
March 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29545753/neuroendocrine-associations-underlying-the-persistent-therapeutic-effects-of-classic-serotonergic-psychedelics
#17
REVIEW
Emmanuelle A D Schindler, Ryan M Wallace, Jordan A Sloshower, Deepak C D'Souza
Recent reports on the effects of psychedelic-assisted therapies for mood disorders and addiction, as well as the effects of psychedelics in the treatment of cluster headache, have demonstrated promising therapeutic results. In addition, the beneficial effects appear to persist well after limited exposure to the drugs, making them particularly appealing as treatments for chronic neuropsychiatric and headache disorders. Understanding the basis of the long-lasting effects, however, will be critical for the continued use and development of this drug class...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29536529/cluster-headache-clinical-phenotypes-tobacco-nonexposed-never-smoker-and-no-parental-secondary-smoke-exposure-as-a-child-versus-tobacco-exposed-results-from-the-united-states-cluster-headache-survey
#18
Todd D Rozen
OBJECTIVE: To present results from the United States Cluster Headache Survey comparing the clinical presentation of tobacco nonexposed and tobacco-exposed cluster headache patients. BACKGROUND: Cluster headache is uniquely tied to a personal history of tobacco usage/cigarette smoking and, if the individual cluster headache sufferer did not smoke, it has been shown that their parent(s) typically did and that individual had significant secondary smoke exposure as a child...
March 14, 2018: Headache
https://www.readbyqxmd.com/read/29523978/pacap-and-its-role-in-primary-headaches
#19
REVIEW
Lars Edvinsson, János Tajti, Levente Szalárdy, László Vécsei
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observed in the sensory trigeminal ganglion (TG), in the parasympathetic sphenopalatine (SPG) and otic ganglia (OTG), and in the brainstem trigeminocervical complex. Immunohistochemistry has shown PACAP-38 in numerous cell bodies of SPG/OTG, co-stored with vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS) and, to a minor degree, with choline acetyltransferase...
March 9, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29517304/defective-functional-connectivity-between-posterior-hypothalamus-and-regions-of-the-diencephalic-mesencephalic-junction-in-chronic-cluster-headache
#20
Stefania Ferraro, Anna Nigri, Maria Grazia Bruzzone, Luca Brivio, Alberto Proietti Cecchini, Mattia Verri, Luisa Chiapparini, Massimo Leone
Objective We tested the hypothesis of a defective functional connectivity between the posterior hypothalamus and diencephalic-mesencephalic regions in chronic cluster headache based on: a) clinical and neuro-endocrinological findings in cluster headache patients; b) neuroimaging findings during cluster headache attacks; c) neuroimaging findings in drug-refractory chronic cluster headache patients improved after successful deep brain stimulation. Methods Resting state functional magnetic resonance imaging, associated with a seed-based approach, was employed to investigate the functional connectivity of the posterior hypothalamus in chronic cluster headache patients (n = 17) compared to age and sex-matched healthy subjects (n = 16)...
January 1, 2018: Cephalalgia: An International Journal of Headache
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