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Testosterone Cypionate

Aristotelis Kotronoulas, Àlex Gomez-Gómez, Andreu Fabregat, Jordi Segura, Sheng Yang, Yanyi Xing, Wu Moutian, Josep Marcos, Jesús Joglar, Rosa Ventura, Oscar J Pozo
In the fight against doping, the introduction of alternative markers to the steroid profile can be considered as an effective approach to improve the screening capabilities for the detection of testosterone (T) misuse. The aim of this study was to evaluate the potential of several T metabolites (cysteinyl conjugated and glucuronoconjugated resistant to enzymatic hydrolysis) to detect both the transdermal and the intramuscular administration of T. In a first part of the study, we studied the potential of these metabolites for the detection of T transdermal administration...
November 22, 2017: Drug Testing and Analysis
Naiara C S Ribeiro, Mônica S Campos, Mariana B Santos, Gabriela M Ayusso, Patrícia S L Vilamaior, Luis O Regasini, Sebastião R Taboga, Manoel F Biancardi, Ana P S Perez, Fernanda C A Santos
Chrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown, especially during its development and functional maturation. Thus, the aim of this study was to evaluate the effects of chrysin prepubertal exposure on the male and female prostates of both pubertal and adult gerbils. To evaluate the possible androgenic responses of chrysin, gerbils were also exposed to testosterone...
November 10, 2017: Fitoterapia
Jean-Sébastien Palerme, Allison Mazepa, Rae G Hutchins, Vincent Ziglioli, Shelly L Vaden
Urethral sphincter mechanism incompetence (USMI) is reported much more seldom in male dogs than in female dogs. The few existing reports evaluating the efficacy of medical therapy in controlling USMI in males have demonstrated limited success. In this case series, we report the effect of testosterone cypionate, given at a median dose of 1.5 mg/kg intramuscularly every 4 wk, in eight male dogs with USMI. Response was evaluated through the review of medical records and telephone interviews with the clients. Based on owners' assessments, a good to excellent response was reported in three of eight dogs (38%), a slight response was reported in one of eight dogs (12%), and a poor response was reported in four of eight dogs (50%)...
August 9, 2017: Journal of the American Animal Hospital Association
Yonah Krakowsky, William Conners, Emily Davidson, Alex Rawji, Abraham Morgentaler
OBJECTIVE: To report our initial experiences with testosterone undecanoate (TU 750) mg (AVEED) in men with testosterone deficiency. METHODS: All patients receiving TU 750 mg at our center between July 1, 2014, and August 1, 2016, were identified. Clinical response was assessed through structured interviews and laboratory evaluations. Adverse events were documented, including increase in prostate specific antigen (PSA), increase in hematocrit (Hct), and the development of postinjection cough...
November 2017: Urology
Andrew S Flum, Paula R Firmiss, Diana K Bowen, Natalie Kukulka, Grace B Delos Santos, Robert W Dettman, Edward M Gong
Lower urinary tract symptoms secondary to posterior urethral valves (PUV) arise in boys during adolescence. The reasons for this have previously been attributed to increased urine output as boys experience increased growth. Additionally, there are few choices for clinicians to effectively treat these complications. We formed the new hypothesis that increased androgen levels at this time of childhood development could play a role at the cellular level in obstructed bladders. To test this hypothesis, we investigated the role of testosterone on bladder detrusor muscle following injury from partial bladder outlet obstruction (PO) in mice...
2017: Frontiers in Pediatrics
Daniel I Spratt, India I Stewart, Clara Savage, Wendy Craig, Norman P Spack, Donald Walt Chandler, Lindsey V Spratt, Toni Eimicke, Jerrold S Olshan
Context: Testosterone (T) is commonly administered intramuscularly to treat hypogonadal males and female-to-male (FTM) transgender patients. However, these injections can involve significant discomfort and may require arrangements for administration by others. Objective: We assessed whether T could be administered effectively and safely subcutaneously as an alternative to intramuscular (IM) injections. Design: Retrospective cohort study. Setting: Outpatient reproductive endocrinology clinic at an academic medical center...
July 1, 2017: Journal of Clinical Endocrinology and Metabolism
Nicolas Fabresse, Stanislas Grassin-Delyle, Isabelle Etting, Jean-Claude Alvarez
We developed and validated a method to detect and quantify 12 anabolic steroids in blood (androstenedione, dihydrotestosterone, boldenone, epitestosterone, mesterolone, methandienone, nandrolone, stanozolol, norandrostenedione, tamoxifene, testosterone, trenbolone) and eight more in hair samples (nandrolone phenylpropionate, nandrolone decanoate, testosterone propionate, testosterone benzoate, testosterone cypionate, testosterone decanoate, testosterone phenylpropionate, testosterone undecanoate) using liquid chromatography coupled to high-resolution mass spectrometry...
July 2017: International Journal of Legal Medicine
J A Sauls, B E Voelz, S L Hill, L G D Mendonça, J S Stevenson
Using an activity monitoring system (AMS) equipped with an accelerometer, 2 experiments were conducted to test the hypotheses that (1) enhancing progesterone before inducing luteolysis or (2) exposing cows to estradiol cypionate (ECP) or testosterone propionate (TP) after luteolysis would increase occurrence and intensity of estrus. Our goal was to determine if more cows could be detected in estrus by an AMS compared with other estrus-detection aids. In experiment 1, cows (n=154) were fitted with both an AMS collar and a pressure-sensitive, rump-mounted device (HeatWatch; HW) and assigned to 3 treatments: (1) no CL + progesterone insert (CIDR) for 5d, (2) CL only, or (3) CL + 2 CIDR inserts for 5d to achieve a range in concentrations of progesterone...
January 2017: Journal of Dairy Science
Charles J Glueck, Kevin Lee, Marloe Prince, Vybhav Jetty, Parth Shah, Ping Wang
BACKGROUND: When exogenous testosterone or treatments to elevate testosterone (human chorionic gonadotropin [HCG] or Clomid) are prescribed for men who have antecedent thrombophilia, deep venous thrombosis and pulmonary embolism often occur and may recur despite adequate anticoagulation if testosterone therapy is continued. CASE PRESENTATION: A 55-year-old white male was referred to us because of 4 thrombotic events, 3 despite adequate anticoagulation over a 5-year period...
July 2016: Journal of Investigative Medicine High Impact Case Reports
Michael T Schweizer, Hao Wang, Brandon Luber, Rosa Nadal, Avery Spitz, D Marc Rosen, Haiyi Cao, Emmanuel S Antonarakis, Mario A Eisenberger, Michael A Carducci, Channing Paller, Samuel R Denmeade
BACKGROUND: We have previously documented a paradoxical anti-tumor effect when castration-resistant prostate cancer patients were treated with intermittent, high-dose testosterone (i.e., Bipolar Androgen Therapy; BAT). Because, an adaptive increase in androgen receptor expression following chronic androgen deprivation therapy (ADT) may underlie this effect, we tested whether men with hormone-sensitive (HS) prostate cancer (PC) would also respond to BAT if given following a 6-month ADT lead-in...
September 2016: Prostate
Michael M Pan, Jason R Kovac
Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Current medical treatment focuses on testosterone supplementation using multiple modalities such as injections, gels and pellets. Interestingly, while testosterone is considered an anabolic androgenic steroid, it has not been saddled with the social stigma that other, similar medications have. The goal of this review is to highlight an anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) and illustrate prospective therapeutic applications for male health...
April 2016: Translational Andrology and Urology
Matthew LaClair, Agnès Lacreuse
This study examined sex differences in executive function in middle-aged gonadectomized marmosets (Callithrix jacchus) with or without hormonal replacement. We tested ten castrated male (mean age 5.5 years) marmosets treated with testosterone cypionate (T, n = 5) or vehicle (n = 5) on Reversal Learning, which contributes to cognitive flexibility, and the Delayed Response task, measuring working memory. Their performance was compared to that of 11 ovariectomized females (mean age = 3.7 years) treated with Silastic capsules filled with 17-β estradiol (E2, n = 6) or empty capsules (n = 5), previously tested on the same tasks (Lacreuse et al...
May 2016: Animal Cognition
Letícia Nobre Lopes, Felipe Augusto Folha Santos, Louize Caroline Marques Oliveira, Marialva Tereza Ferreira Araujo, Carina Guilhon Sequeira, Rosana Maria Feio Libonati, Ana Maria Revoredo da Silva Ventura
Sex steroids can determine several responses in the clinical evolution of malaria. Seventy Balb-c mice were randomly distributed into 7 groups (10 mice per group): G1 to G6 corresponding to castrated females, castrated females that received estradiol cypionate, uncastrated females, castrated males, castrated males that received intramuscular testosterone decanoate and uncastrated males infected with Plasmodium berghei, and G7, the control group. The mice were evaluated with regard to survival, parasitemia, temperature, body weight, hemoglobin level (anemia) and splenic index...
January 2016: Microbial Pathogenesis
Montse Raro, María Ibáñez, Rubén Gil, Andreu Fabregat, Eva Tudela, Koen Deventer, Rosa Ventura, Jordi Segura, Josep Marcos, Aristotelis Kotronoulas, Jesús Joglar, Magi Farré, Sheng Yang, Yanyi Xing, Peter Van Eenoo, Elena Pitarch, Félix Hernández, Juan Vicente Sancho, Óscar J Pozo
The use of untargeted metabolomics for the discovery of markers is a promising and virtually unexplored tool in the doping control field. Hybrid quadrupole time-of-flight (QTOF) and hybrid quadrupole Orbitrap (Q Exactive) mass spectrometers, coupled to ultrahigh pressure liquid chromatography, are excellent tools for this purpose. In the present work, QTOF and Q Exactive have been used to look for markers for testosterone cypionate misuse by means of untargeted metabolomics. Two different groups of urine samples were analyzed, collected before and after the intramuscular administration of testosterone cypionate...
August 18, 2015: Analytical Chemistry
Matthias D Hofer, Earl Y Cheng, Matthew I Bury, Wei Xu, Seok Jong Hong, William E Kaplan, Arun K Sharma
OBJECTIVE: To describe the effects of androgens on urethral wound healing, we compared the urethral healing process in castrated Sprague-Dawley rats with and without testosterone supplementation. METHODS: Of 30 castrated male Sprague-Dawley rats, 15 received testosterone cypionate (3 mg/kg; T+ rats). All rats underwent an urethroplasty procedure and were sacrificed at postoperative days 5, 10, and 20. Neutrophils, macrophages, vessels, myofibroblasts, Ki67+ cells, collagen, and cytokines were quantified with immunofluorescence and real-time polymerase chain reaction...
March 2015: Urology
André R Peixoto, Talita M Santos, Joyce Z Brandt, Flávia K Delella, Bianca F Gonçalves, Silvana G P Campos, Sebastião R Taboga, Wagner J Favaro, Raquel F Domeniconi, Wellerson R Scarano
In the present study, it was evaluated the susceptibility of prostatic lesions in male adult rats exposed to Di-N-butyl-phthalate during fetal and lactational periods and submitted to MNU plus testosterone carcinogenesis protocol. Pregnant females were distributed into four experimental groups: CN (negative control); CMNU (MNU control); TDBP100 (100 mg/kg of DBP); TDBP500 (500 mg/kg of DBP). Females from the TDBP groups received DBP, by gavage, from gestation day 15 (GD15) to postnatal day 21 (DPN21), while C animals received the vehicle (corn oil)...
October 2016: Environmental Toxicology
Michael T Schweizer, Emmanuel S Antonarakis, Hao Wang, A Seun Ajiboye, Avery Spitz, Haiyi Cao, Jun Luo, Michael C Haffner, Srinivasan Yegnasubramanian, Michael A Carducci, Mario A Eisenberger, John T Isaacs, Samuel R Denmeade
Targeting androgen receptor (AR) axis signaling by disrupting androgen-AR interactions remains the primary treatment for metastatic prostate cancer. Unfortunately, all men develop resistance to primary castrating therapy and secondary androgen deprivation therapies (ADTs). Resistance develops in part because castration-resistant prostate cancer (CRPC) cells adaptively up-regulate AR levels through overexpression, amplification, and expression of ligand-independent variants in response to chronic exposure to a low-testosterone environment...
January 7, 2015: Science Translational Medicine
Leonardo O Mendes, Wellerson R Scarano, Sabrina S Rochel-Maia, Beatriz A Fioruci-Fontaneli, Luiz G A Chuffa, Janete A Anselmo-Franci, Francisco E Martinez
AIMS: Chronic ethanol consumption leads to reproductive damages, since it can act directly in the tissues or indirectly, causing a hormonal imbalance. Prostate is a hormone-dependent gland and, consequently, susceptible to ethanol. The potential of testosterone therapy in the ethanol-related disorders was investigated in the prostate microenvironment. MAIN METHODS: UChB rats aged 90 days were divided into 2 experimental groups (n=20): C: drinking water only and EtOH: drinking 10% (v/v) ethanol at >2 g/kg body weight/day+water...
January 1, 2015: Life Sciences
F H Benoff
Precocious adult sexual behavior was determined for chicks from two lines of chickens selected bidirectionally for adult mating frequency. Three-day-old chicks were injected with either 0 or 12.5 mg testosterone cypionate (TC) in sesame oil, and their sexual responses to a hand thrust test (HTT) measured at 10, 12, 14, 16 and 18 days of age. TC stimulated copulation in both the high and low mating line, while birds receiving injections of the vehicle only, failed to copulate. There were differences in precocious sexual behavior between lines at this young age, although further differential maturation of neural tissues mediating mating behavior may occur...
April 1979: Behavioural Processes
Laura Tretzel, Andreas Thomas, Hans Geyer, Günter Gmeiner, Guro Forsdahl, Valentin Pop, Wilhelm Schänzer, Mario Thevis
Dried blood spot (DBS) sampling, a technique for whole blood sampling on a piece of filter paper, has more than 50-years tradition, particularly in the diagnostic analysis of metabolic disorders in neonatal screening. Due to the minimal invasiveness, straightforwardness, robustness against manipulation and fastness DBS sampling recommends itself as an advantageous technique in doping control analysis. The present approach highlights the development of a screening assay for the analysis of eight anabolic steroid esters (nandrolone phenylpropionate, trenbolone enanthate, testosterone acetate, testosterone cypionate, testosterone isocaproate, testosterone phenylpropionate, testosterone decanoate and testosterone undecanoate) and nandrolone in DBS...
August 5, 2014: Journal of Pharmaceutical and Biomedical Analysis
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