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Testosterone Cypionate

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https://www.readbyqxmd.com/read/27889121/increasing-estrus-expression-in-the-lactating-dairy-cow
#1
J A Sauls, B E Voelz, S L Hill, L G D Mendonça, J S Stevenson
Using an activity monitoring system (AMS) equipped with an accelerometer, 2 experiments were conducted to test the hypotheses that (1) enhancing progesterone before inducing luteolysis or (2) exposing cows to estradiol cypionate (ECP) or testosterone propionate (TP) after luteolysis would increase occurrence and intensity of estrus. Our goal was to determine if more cows could be detected in estrus by an AMS compared with other estrus-detection aids. In experiment 1, cows (n = 154) were fitted with both an AMS collar and a pressure-sensitive, rump-mounted device (HeatWatch; HW) and assigned to 3 treatments: (1) no CL + progesterone insert (CIDR) for 5 d, (2) CL only, or (3) CL + 2 CIDR inserts for 5 d to achieve a range in concentrations of progesterone...
November 23, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27536705/four-thrombotic-events-over-5-years-two-pulmonary-emboli-and-two-deep-venous-thrombosis-when-testosterone-hcg-therapy-was-continued-despite-concurrent-anticoagulation-in-a-55-year-old-man-with-lupus-anticoagulant
#2
Charles J Glueck, Kevin Lee, Marloe Prince, Vybhav Jetty, Parth Shah, Ping Wang
BACKGROUND: When exogenous testosterone or treatments to elevate testosterone (human chorionic gonadotropin [HCG] or Clomid) are prescribed for men who have antecedent thrombophilia, deep venous thrombosis and pulmonary embolism often occur and may recur despite adequate anticoagulation if testosterone therapy is continued. CASE PRESENTATION: A 55-year-old white male was referred to us because of 4 thrombotic events, 3 despite adequate anticoagulation over a 5-year period...
July 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/27338150/bipolar-androgen-therapy-for-men-with-androgen-ablation-na%C3%A3-ve-prostate-cancer-results-from-the-phase-ii-batman-study
#3
Michael T Schweizer, Hao Wang, Brandon Luber, Rosa Nadal, Avery Spitz, D Marc Rosen, Haiyi Cao, Emmanuel S Antonarakis, Mario A Eisenberger, Michael A Carducci, Channing Paller, Samuel R Denmeade
BACKGROUND: We have previously documented a paradoxical anti-tumor effect when castration-resistant prostate cancer patients were treated with intermittent, high-dose testosterone (i.e., Bipolar Androgen Therapy; BAT). Because, an adaptive increase in androgen receptor expression following chronic androgen deprivation therapy (ADT) may underlie this effect, we tested whether men with hormone-sensitive (HS) prostate cancer (PC) would also respond to BAT if given following a 6-month ADT lead-in...
September 2016: Prostate
https://www.readbyqxmd.com/read/27141449/beyond-testosterone-cypionate-evidence-behind-the-use-of-nandrolone-in-male-health-and-wellness
#4
REVIEW
Michael M Pan, Jason R Kovac
Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Current medical treatment focuses on testosterone supplementation using multiple modalities such as injections, gels and pellets. Interestingly, while testosterone is considered an anabolic androgenic steroid, it has not been saddled with the social stigma that other, similar medications have. The goal of this review is to highlight an anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) and illustrate prospective therapeutic applications for male health...
April 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/26909674/reversal-learning-in-gonadectomized-marmosets-with-and-without-hormone-replacement-are-males-more-sensitive-to-punishment
#5
Matthew LaClair, Agnès Lacreuse
This study examined sex differences in executive function in middle-aged gonadectomized marmosets (Callithrix jacchus) with or without hormonal replacement. We tested ten castrated male (mean age 5.5 years) marmosets treated with testosterone cypionate (T, n = 5) or vehicle (n = 5) on Reversal Learning, which contributes to cognitive flexibility, and the Delayed Response task, measuring working memory. Their performance was compared to that of 11 ovariectomized females (mean age = 3.7 years) treated with Silastic capsules filled with 17-β estradiol (E2, n = 6) or empty capsules (n = 5), previously tested on the same tasks (Lacreuse et al...
May 2016: Animal Cognition
https://www.readbyqxmd.com/read/26549492/an-analysis-of-the-influence-of-sex-hormones-on-balb-c-mice-infected-with-plasmodium-berghei
#6
Letícia Nobre Lopes, Felipe Augusto Folha Santos, Louize Caroline Marques Oliveira, Marialva Tereza Ferreira Araujo, Carina Guilhon Sequeira, Rosana Maria Feio Libonati, Ana Maria Revoredo da Silva Ventura
Sex steroids can determine several responses in the clinical evolution of malaria. Seventy Balb-c mice were randomly distributed into 7 groups (10 mice per group): G1 to G6 corresponding to castrated females, castrated females that received estradiol cypionate, uncastrated females, castrated males, castrated males that received intramuscular testosterone decanoate and uncastrated males infected with Plasmodium berghei, and G7, the control group. The mice were evaluated with regard to survival, parasitemia, temperature, body weight, hemoglobin level (anemia) and splenic index...
January 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/26200763/untargeted-metabolomics-in-doping-control-detection-of-new-markers-of-testosterone-misuse-by-ultrahigh-performance-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry
#7
Montse Raro, María Ibáñez, Rubén Gil, Andreu Fabregat, Eva Tudela, Koen Deventer, Rosa Ventura, Jordi Segura, Josep Marcos, Aristotelis Kotronoulas, Jesús Joglar, Magi Farré, Sheng Yang, Yanyi Xing, Peter Van Eenoo, Elena Pitarch, Félix Hernández, Juan Vicente Sancho, Óscar J Pozo
The use of untargeted metabolomics for the discovery of markers is a promising and virtually unexplored tool in the doping control field. Hybrid quadrupole time-of-flight (QTOF) and hybrid quadrupole Orbitrap (Q Exactive) mass spectrometers, coupled to ultrahigh pressure liquid chromatography, are excellent tools for this purpose. In the present work, QTOF and Q Exactive have been used to look for markers for testosterone cypionate misuse by means of untargeted metabolomics. Two different groups of urine samples were analyzed, collected before and after the intramuscular administration of testosterone cypionate...
August 18, 2015: Analytical Chemistry
https://www.readbyqxmd.com/read/25733291/androgen-supplementation-in-rats-increases-the-inflammatory-response-and-prolongs-urethral-healing
#8
Matthias D Hofer, Earl Y Cheng, Matthew I Bury, Wei Xu, Seok Jong Hong, William E Kaplan, Arun K Sharma
OBJECTIVE: To describe the effects of androgens on urethral wound healing, we compared the urethral healing process in castrated Sprague-Dawley rats with and without testosterone supplementation. METHODS: Of 30 castrated male Sprague-Dawley rats, 15 received testosterone cypionate (3 mg/kg; T+ rats). All rats underwent an urethroplasty procedure and were sacrificed at postoperative days 5, 10, and 20. Neutrophils, macrophages, vessels, myofibroblasts, Ki67+ cells, collagen, and cytokines were quantified with immunofluorescence and real-time polymerase chain reaction...
March 2015: Urology
https://www.readbyqxmd.com/read/25728413/gestational-and-lactational-exposition-to-di-n-butyl-phthalate-dbp-increases-inflammation-and-preneoplastic-lesions-in-prostate-of-wistar-rats-after-carcinogenic-n-methyl-n-nitrosourea-mnu-plus-testosterone-protocol
#9
André R Peixoto, Talita M Santos, Joyce Z Brandt, Flávia K Delella, Bianca F Gonçalves, Silvana G P Campos, Sebastião R Taboga, Wagner J Favaro, Raquel F Domeniconi, Wellerson R Scarano
In the present study, it was evaluated the susceptibility of prostatic lesions in male adult rats exposed to Di-N-butyl-phthalate during fetal and lactational periods and submitted to MNU plus testosterone carcinogenesis protocol. Pregnant females were distributed into four experimental groups: CN (negative control); CMNU (MNU control); TDBP100 (100 mg/kg of DBP); TDBP500 (500 mg/kg of DBP). Females from the TDBP groups received DBP, by gavage, from gestation day 15 (GD15) to postnatal day 21 (DPN21), while C animals received the vehicle (corn oil)...
October 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/25568070/effect-of-bipolar-androgen-therapy-for-asymptomatic-men-with-castration-resistant-prostate-cancer-results-from-a-pilot-clinical-study
#10
Michael T Schweizer, Emmanuel S Antonarakis, Hao Wang, A Seun Ajiboye, Avery Spitz, Haiyi Cao, Jun Luo, Michael C Haffner, Srinivasan Yegnasubramanian, Michael A Carducci, Mario A Eisenberger, John T Isaacs, Samuel R Denmeade
Targeting androgen receptor (AR) axis signaling by disrupting androgen-AR interactions remains the primary treatment for metastatic prostate cancer. Unfortunately, all men develop resistance to primary castrating therapy and secondary androgen deprivation therapies (ADTs). Resistance develops in part because castration-resistant prostate cancer (CRPC) cells adaptively up-regulate AR levels through overexpression, amplification, and expression of ligand-independent variants in response to chronic exposure to a low-testosterone environment...
January 7, 2015: Science Translational Medicine
https://www.readbyqxmd.com/read/25447451/androgen-therapy-reverses-injuries-caused-by-ethanol-consumption-in-the-prostate-testosterone-as-a-possible-target-to-ethanol-related-disorders
#11
Leonardo O Mendes, Wellerson R Scarano, Sabrina S Rochel-Maia, Beatriz A Fioruci-Fontaneli, Luiz G A Chuffa, Janete A Anselmo-Franci, Francisco E Martinez
AIMS: Chronic ethanol consumption leads to reproductive damages, since it can act directly in the tissues or indirectly, causing a hormonal imbalance. Prostate is a hormone-dependent gland and, consequently, susceptible to ethanol. The potential of testosterone therapy in the ethanol-related disorders was investigated in the prostate microenvironment. MAIN METHODS: UChB rats aged 90 days were divided into 2 experimental groups (n=20): C: drinking water only and EtOH: drinking 10% (v/v) ethanol at >2 g/kg body weight/day+water...
January 1, 2015: Life Sciences
https://www.readbyqxmd.com/read/24896388/testosterone-induced-precocious-sexual-behavior-in-chickens-differing-in-adult-mating-frequency
#12
F H Benoff
Precocious adult sexual behavior was determined for chicks from two lines of chickens selected bidirectionally for adult mating frequency. Three-day-old chicks were injected with either 0 or 12.5 mg testosterone cypionate (TC) in sesame oil, and their sexual responses to a hand thrust test (HTT) measured at 10, 12, 14, 16 and 18 days of age. TC stimulated copulation in both the high and low mating line, while birds receiving injections of the vehicle only, failed to copulate. There were differences in precocious sexual behavior between lines at this young age, although further differential maturation of neural tissues mediating mating behavior may occur...
April 1979: Behavioural Processes
https://www.readbyqxmd.com/read/24713476/use-of-dried-blood-spots-in-doping-control-analysis-of-anabolic-steroid-esters
#13
Laura Tretzel, Andreas Thomas, Hans Geyer, Günter Gmeiner, Guro Forsdahl, Valentin Pop, Wilhelm Schänzer, Mario Thevis
Dried blood spot (DBS) sampling, a technique for whole blood sampling on a piece of filter paper, has more than 50-years tradition, particularly in the diagnostic analysis of metabolic disorders in neonatal screening. Due to the minimal invasiveness, straightforwardness, robustness against manipulation and fastness DBS sampling recommends itself as an advantageous technique in doping control analysis. The present approach highlights the development of a screening assay for the analysis of eight anabolic steroid esters (nandrolone phenylpropionate, trenbolone enanthate, testosterone acetate, testosterone cypionate, testosterone isocaproate, testosterone phenylpropionate, testosterone decanoate and testosterone undecanoate) and nandrolone in DBS...
August 5, 2014: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/24510484/population-based-patterns-of-prescription-androgen-use-1976-2008
#14
Susan A Hall, Gayatri Ranganathan, Liane J Tinsley, Jennifer L Lund, Varant Kupelian, Gary A Wittert, Philip W Kantoff, Alvaro Morales, Andre B Araujo
PURPOSE: Prescription testosterone (T) has limited approved medical indications and is a controlled substance in Canada. Utilization studies in other Westernized countries have revealed sharp increases in T use in recent years. We examined medical use of androgens, including T, over a ≥30-year period among adult (18+) men in a population-based study set in a Canadian juridisdiction of universal health care. METHODS: Analyses were based on data from electronic records of dispensed prescriptions during 1976-2008 in Saskatchewan, Canada...
May 2014: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/24203640/treatment-of-depression-in-hiv-men-literature-review-and-report-of-an-ongoing-study-of-testosterone-replacement-therapy
#15
J G Rabkin, G Wagner, R Rabkin
Our research program was designed to assess androgenic, anabolic, and mood effects of testosterone replacement therapy in human immunodeficiency virus positive (HIV+) men with significant immune suppression and hypogonadism. This article focuses on mood effects. Treatment consisted of biweekly intramuscular injections of testosterone cypionate at doses of 200 to 400 mg. Assessments included psychiatric evaluation using the Structured Clinical Interview for DSM-III-R, Hamilton Rating Scale for Depression, and Brief Symptom Inventory...
March 1996: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/23985714/quantitation-of-testosterone-cypionate-in-oil-injection-using-high-performance-liquid-chromatography
#16
V D Gupta, Y Pramar
A high-performance liquid chromatography assay method for the quantitation of testosterone-cypionate-in-oil injection has been developed. The assay method is very simple, accurate and precise, with a percent relative standard deviation of 1.2 based on five readings. The extraction procedure is very simple compared with a very tedious and time-consuming procedure given in the United States Pharmacopoeia/National Formulary. The USP-NF assay method is based on gas chromatography. The benzyl alcohol (preservative) did not interfere with the assay preocedure...
July 1999: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/23985557/quantitation-of-testosterone-propionate-in-an-injection-using-high-performance-liquid-chromatography
#17
V D Gupta
A high-performance liquid chromatography assay method for the quantition of testosterone propionate in an injection has been developed. The assay method is very simple, precise and accurate, with a percent relative standard deviation of 1.3 based on five injections. The benzyl alcohol (the preservative) and sesame oil (the vehicle) did not interfere with the assay procedure. The extraction procedure is very simple compared with a tedious and time-consuming method recommended in the USP-NF. The other similar compounds, testosterone, methyltestosterone, testosterone cypionate and testosterone enanthate, did not interfere with the assay method...
March 1999: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/23962431/objective-use-of-testosterone-reveals-androgen-insensitivity-in-patients-with-proximal-hypospadias
#18
Warren T Snodgrass, Carlos Villanueva, Candace Granberg, Nicol Corbin Bush
OBJECTIVE: We report preoperative testosterone stimulation based on glans width measurements in patients with midshaft and proximal hypospadias, revealing androgen resistance in those with proximal hypospadias. METHODS: Patients had maximum glans width measured preoperatively. Those <14 mm initially received 2 mg/kg testosterone cypionate intramuscularly for two to three doses, with the aim of increasing glans width ≥ 15 mm. Not all patients achieved targeted growth, and some were subsequently treated with escalating doses of testosterone...
February 2014: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/23807524/hormone-replacement-therapy-in-children-with-hypogonadotropic-hypogonadism-where-do-we-stand
#19
Zeina Nabhan, Erica A Eugster
OBJECTIVE: To characterize hormone replacement therapy in a cohort of adolescent males and females with hypogonadotropic hypogonadism (HH) with a focus on changes in management during the past 10 years. METHODS: Medical records of patients followed for HH during the past 10 years were reviewed. RESULTS: A total of 45 patients (22 female: 23 male) with HH were identified. The average age at HH diagnosis was 14.48 ± 2.02 years in females and 14...
November 2013: Endocrine Practice
https://www.readbyqxmd.com/read/23474392/genotoxic-and-cytotoxic-effects-of-testosterone-cypionate-deposteron-%C3%A2
#20
José Roberto C Meireles, Susie V Oliveira, Antônio O Costa-Neto, Eneida M M Cerqueira
The indiscriminate use of anabolic androgenic steroids (AAS) has motivated researchers to investigate the mutagenic action of these substances. The present study, using the mouse bone marrow micronucleus test, evaluates the genotoxic potential of testosterone cypionate (deposteron). Male Swiss mice received intramuscular injections of deposteron at three doses. The animals were sacrificed 24, 48, or 72h after treatment and bone marrow was removed immediately, followed by scoring to count the micronuclei in 2000 polychromatic erythrocytes (PCE)...
May 15, 2013: Mutation Research
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