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https://www.readbyqxmd.com/read/29241179/rs739837-polymorphism-in-mir-885-3p-binding-site-within-3-untranslated-region-of-vitamin-d-receptor-is-associated-with-a-decreased-risk-of-pressure-ulcers
#1
Xia Ji, Jinbao Mao, Shuang Zhou
BACKGROUND/AIMS: Accumulative evidence has shown that miR-885-3p plays a crucial role in human carcinogenesis. From miRNA database, we also found that rs739837 polymorphism in miR-885-3p binding site within 3'-untranslated region of Vitamin D receptor (VDR), compromising the suppressive effect of miR-885-3p on VDR. Moreover, Vitamin D is involved in controlling the cell immune response and may play a role in pressure ulcers development. However, whether this polymorphism is actually linked with pressure ulcers remains unclear...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241119/bench-to-bedside-review-possible-role-of-vitamin-d-in-autism-spectrum-disorder
#2
REVIEW
Feiyong Jia, Ling Shan, Bing Wang, Honghua Li, Chunyue Miao, Zhida Xu, Ching-Po Lin, Khaled Saad
Autism spectrum disorder (ASD) is a group of dysfunctions in social interaction, communication, and behaviors. Studies have demonstrated that vitamin D deficiency during pregnancy and in individuals increased the risk of ASD. A genetic polymorphism study has pinpointed that genotype AA/A-allele of GC rs4588 in children is associated with ASD, which encodes the vitamin D binding protein. Translating the mentioned points into clinical practice, several clinical trials have demonstrated that vitamin D supplementation can improve the core symptoms in children with ASD...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29240960/variant-rs2200733-and-rs10033464-on-chromosome-4q25-are-associated-with-increased-risk-of-atrial-fibrillation-after-catheter-ablation-evidence-from-a-meta-analysis
#3
Jiake He, Wengen Zhu, Yang Yu, Jinzhu Hu, Kui Hong
BACKGROUND: Common genetic polymorphisms at chromosome 4q25 were associated with increased susceptibility to atrial fibrillation (AF). However, it remained controversial whether these variants could be used as risk predictors for AF recurrence after catheter ablation. We therefore performed a meta-analysis to quantify the association between rs2200733 C>T/rs10033464 G>T and AF recurrence. METHODS: Relevant studies were systematically retrieved from PubMed, Web of science, Elsevier database and Cochrane library through November 2016...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29240932/homogenization-of-populations-in-the-wildflower-texas-bluebonnet-lupinus-texensis
#4
Kathryn G Turner, Daisie I Huang, Quentin C B Cronk, Loren H Rieseberg
Wildflower seeds are routinely spread along highways and thoroughfares throughout North America as part of federal beautification policy, but the genetic effect of the introduction of these cultivated populations on wild populations of the same species is unknown. Interbreeding may occur between these seeded and wild populations, resulting in several possible outcomes. Here we sample 187 individuals in 12 matched pairs of neighboring wild and seeded populations of the Texas bluebonnet (Lupinus texensis), a species popular in commercially available wildflower seed mixes used by both the Texas Department of Transportation and the public...
December 12, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29240876/machine-learning-for-classifying-tuberculosis-drug-resistance-from-dna-sequencing-data
#5
Yang Yang, Katherine E Niehaus, Timothy M Walker, Zamin Iqbal, A Sarah Walker, Daniel J Wilson, Tim E Peto, Derrick W Crook, E Grace Smith, Tingting Zhu, David A Clifton
Motivation: Correct and rapid determination of Mycobacterium tuberculosis (MTB) resistance against available tuberculosis (TB) drugs is essential for the control and management of TB. Conventional molecular diagnostic test assumes that the presence of any well-studied single nucleotide polymorphisms is sufficient to cause resistance, which yields low sensitivity for resistance classification. Methods: Given the availability of DNA sequencing data from MTB, we developed machine learning models for a cohort of 1839 UK bacterial isolates to classify MTB resistance against eight anti-TB drugs (isoniazid, rifampicin, ethambutol, pyrazinamide, ciprofloxacin, moxifloxacin, ofloxacin, streptomycin) and to classify multi-drug resistance...
December 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29240824/high-abundance-of-arfgap1-found-in-the-mossy-fibers-in-hilus-of-the-dentate-gyrus-region-of-the-mouse-brain
#6
Sergiy Chornyy, Anna Parnis, Michael Shmoish, Dan Cassel
The Arf GTPase-activating protein ArfGAP1 and its brain-specific isoform ArfGAP1B play an important role in neurotransmission. Here we analyzed the distribution of ArfGAP1 in the mouse brain. We found high levels of ArfGAP1 in the mouse dentate gyrus where it displayed especially elevated level in the polymorph layer (hilus). Importantly, the ArfGAP1 signal follows the pathway of the granular cell axons so-called mossy fibers which extend from the dentate gyrus to CA3 via stratum lucidum and partially stratum oriens...
2017: PloS One
https://www.readbyqxmd.com/read/29240768/the-association-between-the-nicotinic-acetylcholine-receptor-%C3%AE-4-subunit-gene-chrna4-rs1044396-and-internet-gaming-disorder-in-korean-male-adults
#7
Jo-Eun Jeong, Je-Keun Rhee, Tae-Min Kim, Su-Min Kwak, Sol-Hee Bang, Hyun Cho, Young-Hoon Cheon, Jung Ah Min, Gil Sang Yoo, Kyudong Kim, Jung-Seok Choi, Sam-Wook Choi, Dai-Jin Kim
The primary aim of this study was to investigate the genetic predisposition of Internet gaming disorder (IGD), and the secondary aim was to compare the results to those of alcohol dependence (AD). Two independent case-control studies were conducted. A total of 30 male participants with IGD, diagnosed according to the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, and 30 sex-matched controls participated in study 1. We designed targeted exome sequencing (TES) to test for 72 candidate genes that have been implicated in the pathogenesis of addiction...
2017: PloS One
https://www.readbyqxmd.com/read/29240764/selection-for-long-and-short-sleep-duration-in-drosophila-melanogaster-reveals-the-complex-genetic-network-underlying-natural-variation-in-sleep
#8
Susan T Harbison, Yazmin L Serrano Negron, Nancy F Hansen, Amanda S Lobell
Why do some individuals need more sleep than others? Forward mutagenesis screens in flies using engineered mutations have established a clear genetic component to sleep duration, revealing mutants that convey very long or short sleep. Whether such extreme long or short sleep could exist in natural populations was unknown. We applied artificial selection for high and low night sleep duration to an outbred population of Drosophila melanogaster for 13 generations. At the end of the selection procedure, night sleep duration diverged by 9...
December 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29240410/determining-the-relative-susceptibility-of-four-prp-genotypes-to-atypical-scrapie
#9
Christopher J Silva, Melissa L Erickson-Beltran, Inmaculada Martin-Burriel, Juan José Badiola, Jesus Rodriguez Requena, Rosa Bolea
Atypical scrapie is a sheep prion (PrPSc) disease whose epidemiology is consistent with a sporadic origin and is associated with specific polymorphisms of the normal cellular prion protein (PrPC). To determine the relative amounts of PrP polymorphisms present in scrapie, total PrP was digested with chymotrypsin to generate characteristic peptides spanning relevant polymorphisms at positions 136, 141, 154, 171 and 172 of sheep PrPC. A multiple reaction monitoring method (MRM), employing 15N-labeled internal standards, was used to detect and quantify these polymorphisms present in both the PrPSc and PrPC from heterozygous (ALRRY and ALHQY or ALRQD or AFRQY) atypical scrapie-infected or uninfected control sheep...
December 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29240274/complement-factor-h-gene-polymorphism-rs6677604-and-the-risk-severity-and-progression-of-iga-nephropathy-a-systematic-review-and-meta-analysis
#10
See Cheng Yeo, Xinyang Liu, Adrian Liew
BACKGROUND & AIM: Complement activation plays a key role in the pathogenesis of IgA nephropathy (IgAN). Several studies have reported an association between complement factor H gene rs6677604 polymorphism and susceptibility to IgAN; however, attempts at validating this relationship had yielded inconsistent results. We performed a systematic review and meta-analysis to clarify the association between rs6677604 and IgAN susceptibility, disease severity and chronic progression. METHODS: A comprehensive database search was performed to identify eligible studies...
December 14, 2017: Nephrology
https://www.readbyqxmd.com/read/29240020/association-study-of-fgf18-with-developmental-dyslexia-in-chinese-population
#11
Huan Chen, Yuxi Zhou, Zeng Ge, Qian Li, Qinsheng Sun, Liyuan Zheng, Hong Lv, Li-Hai Tan, Yimin Sun
Developmental dyslexia (DD) is a neurobiological disorder featured by reading disabilities. In recent years, genome-wide approaches provided new perspectives to discover novel candidate genes of DD. In a previous study, rs9313548 located downstream of FGF18 showed borderline genome-wide significant association with DD. Herein, we selected rs9313548 and 11 independent tag single nucleotide polymorphisms covering gene region of FGF18 to perform association analysis with DD among 978 Chinese dyslexic cases and 998 controls recruited from elementary schools...
December 12, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/29239905/specific-association-of-the-rs6500265-and-rs9933632-single-nucleotide-polymorphisms-in-japanese-patients-with-antipyretic-analgesic-related-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-with-severe-ocular-involvements
#12
Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito
A recent study using the microarray for single-nucleotide polymorphisms (SNPs) genotyping specifically designed for the Japanese population in combination with genome-wide imputation showed the association of several SNPs with cold medicine-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications. However, it remains to be determined whether these polymorphisms are associated with the onset of antipyretic analgesic (AA)-related SJS/TEN, the progression of severe ocular involvements (SOIs), or both AA-related SJS/TEN and SOI phenotypes...
December 12, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29239785/cytokines-dysregulation-in-schizophrenia-a-systematic-review-of-psychoneuroimmune-relationship
#13
REVIEW
Daniela Rodrigues-Amorim, Tania Rivera-Baltanás, Carlos Spuch, Hector J Caruncho, África González-Fernandez, Jose M Olivares, Roberto C Agís-Balboa
INTRODUCTION: Schizophrenia is a multifactorial psychiatric disease with complex interactions among the brain and the immune system. A psycho-immune relationship underling schizophrenia is supported by several studies and integrates a specific area of knowledge - psychoneuroimmunology. METHODS: A systematic review was performed by 2009 Preferred Reporting Items (PRISMA) recommendations. Based on the inclusion/exclusion criteria, publications with relevant information (evaluated by the Joanna Briggs Institute Critical Appraisals tools to quality assessment) were included...
November 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29239496/two-phase-designs-for-joint-quantitative-trait-dependent-and-genotype-dependent-sampling-in-post-gwas-regional-sequencing
#14
Osvaldo Espin-Garcia, Radu V Craiu, Shelley B Bull
We evaluate two-phase designs to follow-up findings from genome-wide association study (GWAS) when the cost of regional sequencing in the entire cohort is prohibitive. We develop novel expectation-maximization-based inference under a semiparametric maximum likelihood formulation tailored for post-GWAS inference. A GWAS-SNP (where SNP is single nucleotide polymorphism) serves as a surrogate covariate in inferring association between a sequence variant and a normally distributed quantitative trait (QT). We assess test validity and quantify efficiency and power of joint QT-SNP-dependent sampling and analysis under alternative sample allocations by simulations...
December 14, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/29239330/expression-of-ng2-and-platelet-derived-growth-factor-receptor-alpha-in-the-developing-neonatal-rat-brain
#15
Ping Li, Heng-Xi Li, Hong-Yan Jiang, Lie Zhu, Hai-Ying Wu, Jin-Tao Li, Jiang-Hua Lai
Platelet-derived growth factor receptor alpha (PDGFRα) is a marker of oligodendrocyte precursor cells in the central nervous system. NG2 is also considered a marker of oligodendrocyte precursor cells. However, whether there are differences in the distribution and morphology of oligodendrocyte precursor cells labeled by NG2 or PDGFRα in the developing neonatal rat brain remains unclear. In this study, by immunohistochemical staining, NG2 positive (NG2+) cells were ubiquitous in the molecular layer, external pyramidal layer, internal pyramidal layer, and polymorphic layer of the cerebral cortex, and corpus callosum, external capsule, piriform cortex, and medial septal nucleus...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29239247/correlations-between-polymorphisms-in-the-uridine-diphosphate-glucuronosyltransferase-1a-and-c-c-motif-chemokine-receptor-5-genes-and-infection-with-the-hepatitis-b-virus-in-three-ethnic-groups-in-china
#16
Chan Zhang, Yan He, Ke-Ren Shan, Kui Tan, Ting Zhang, Chan-Juan Wang, Zhi-Zhong Guan
Objective To determine whether genetic polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A ( UGT1A) and the C-C motif chemokine receptor 5 ( CCR5) genes are associated with hepatitis B virus (HBV) infection in Yi, Yao and Han ethnic groups in the Guizhou Province of China. Methods The study enrolled subjects with and without HBV infection. Whole blood was used for DNA genotyping using standard techniques. The study determined the frequencies of several polymorphic alleles ( UGT1A6 [rs2070959], UGT1A1 [rs8175347], CCR5-59029 [rs1799987] and CCR5Δ32 [rs333]) and then characterized their relationship with HBV infection...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29239112/male-reproductive-tract-and-spermatozoa-ultrastructure-in-the-grasshopper-orphulella-punctata-de-geer-1773-insecta-orthoptera-caelifera
#17
Daniela Santos Martins Silva, Jamile Fernanda Silva Cossolin, Marcelo Ribeiro Pereira, José Lino-Neto, Carlos Frankl Sperber, José Eduardo Serrão
Identification Orphulellini grasshoppers (Acrididae: Gomphocerinae) species has been difficult due to high polymorphism rate. Orphulella Giglio-Tos, 1894 is a genus with widespread geographical distribution and poor descriptions. Orphulella punctata (De Geer, 1773) has an extensive record of occurrence and available information about the phallic complex, however, there is poor data describing other parts of the male reproductive tract. The objective of this study was characterizes the internal organs of the male reproductive system and spermatozoa of O...
December 14, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29239065/vitamin-d-receptor-rs2228570-polymorphism-and-susceptibility-to-ovarian-cancer-an-updated-meta-analysis
#18
Hongmei Chen, Jin Zhu
AIM: The FokI polymorphism (C>T, rs2228570) of the vitamin D receptor gene is a coding nonsynonymous single nucleotide polymorphism in the translational initiation codon reported to have functional significance. Although the role of rs2228570 in the risk of ovarian cancer has been widely researched, the association is still unclear. We performed an updated meta-analysis to clarify this issue. METHODS: Eligible studies were retrieved from electronic databases for the period 2007-2016...
December 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29238938/genetic-polymorphism-and-preterm-birth
#19
REVIEW
Deepak Chawla
No abstract text is available yet for this article.
December 14, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29238544/population-genomics-of-the-asian-tiger-mosquito-aedes-albopictus-insights-into-the-recent-worldwide-invasion
#20
Panayiota Kotsakiozi, Joshua B Richardson, Verena Pichler, Guido Favia, Ademir J Martins, Sandra Urbanelli, Peter A Armbruster, Adalgisa Caccone
Aedes albopictus, the "Asian tiger mosquito," is an aggressive biting mosquito native to Asia that has colonized all continents except Antarctica during the last ~30-40 years. The species is of great public health concern as it can transmit at least 26 arboviruses, including dengue, chikungunya, and Zika viruses. In this study, using double-digest Restriction site-Associated DNA (ddRAD) sequencing, we developed a panel of ~58,000 single nucleotide polymorphisms (SNPs) based on 20 worldwide Ae. albopictus populations representing both the invasive and the native range...
December 2017: Ecology and Evolution
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