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Isis E Fernandez, Flavia R Greiffo, Marion Frankenberger, Julia Bandres, Katharina Heinzelmann, Claus Neurohr, Rudolf Hatz, Dominik Hartl, J├╝rgen Behr, Oliver Eickelberg
Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disease with irreversible lung function loss and poor survival. Myeloid-derived suppressor cells (MDSC) are associated with poor prognosis in cancer, facilitating immune evasion. The abundance and function of MDSC in IPF is currently unknown.Fluorescence-activated cell sorting was performed in 170 patients (IPF: n=69; non-IPF interstitial lung disease (ILD): n=56; chronic obstructive pulmonary disease (COPD): n=23; healthy controls: n=22) to quantify blood MDSC and lymphocyte subtypes...
October 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
SungHwan Kim, Jose D Herazo-Maya, Dongwan D Kang, Brenda M Juan-Guardela, John Tedrow, Fernando J Martinez, Frank C Sciurba, George C Tseng, Naftali Kaminski
BACKGROUND: The increased multi-omics information on carefully phenotyped patients in studies of complex diseases requires novel methods for data integration. Unlike continuous intensity measurements from most omics data sets, phenome data contain clinical variables that are binary, ordinal and categorical. RESULTS: In this paper we introduce an integrative phenotyping framework (iPF) for disease subtype discovery. A feature topology plot was developed for effective dimension reduction and visualization of multi-omics data...
2015: BMC Genomics
Katerina M Antoniou, Simon L Walsh, David M Hansell, Michael R Rubens, Katharina Marten, Rachel Tennant, Trevor Hansel, Sujal R Desai, Nikolaos M Siafakas, Roland M du Bois, Athol U Wells
BACKGROUND AND OBJECTIVE: A combined pulmonary fibrosis/emphysema syndrome has been proposed, but the basis for this syndrome is currently uncertain. The aim was to evaluate the prevalence of emphysema in idiopathic pulmonary fibrosis (IPF) and rheumatoid lung (rheumatoid arthritis-interstitial lung disease (RA-ILD)), and to compare the morphological features of lung fibrosis between smokers and non-smokers. METHODS: Using high-resolution computed tomography, the prevalence of emphysema and the pack-year smoking histories associated with emphysema were compared between current/ex-smokers with IPF (n = 186) or RA-ILD (n = 46), and non-chronic obstructive pulmonary disease (COPD) controls (n = 103) and COPD controls (n = 34)...
November 2013: Respirology: Official Journal of the Asian Pacific Society of Respirology
Kei Ebisawa, Shinji Okada, Norihiro Yamada, Makoto Kobayashi, Yasuko Suzuki, Asami Satoh
SESSION TYPE: ILD Global Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Cottin et al. (2005) characterized a syndrome of combined pulmonary fibrosis and emphysema (CPFE) as a smoking-related disease with severe dyspnea, unexpected subnormal spirometry data, severely impaired diffusion capacity of carbon monoxide (DLco), hypoxemia at exercise, and a characteristic CT finding indicating emphysema and lower-lobe fibrosis. Pulmonary hypertension contributes to the poor prognosis of CPFE...
October 1, 2012: Chest
Baruch Vainshelboim, Mordechai R Kramer
Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease (ILD) characterized by exertional dyspnea, hypoxemia and exercise intolerance. The pathophysiology of IPF usually presents restrictive physiology of lung volume and impaired gas exchange. Most of the research which supports the effectiveness of pulmonary rehabilitation (PR) comes from chronic obstructive pulmonary disease (COPD) patients' studies. However, in the past few years growing evidence has emerged to support the effectiveness and safety of PR programs in IPF patients...
April 2012: Harefuah
Addolorata Corrado, Giovanna Elisiana Carpagnano, Annamaria Gaudio, Maria Pia Foschino-Barbaro, Francesco Paolo Cantatore
OBJECTIVE: Interstitial lung diseases (ILDs) are heterogeneous pathological conditions, which can be idiopathic or associated to other diseases, such as connective tissue diseases (CTD), especially systemic sclersosis (SSc). Both in primary and secondary forms of ILDs, fibroblastic and vascular anomalies are involved in the progressive structural destruction of lung parenchyma. Nailfold video-capillaroscopy (NFC) is a non-invasive diagnostic tool that permits detection of the main local microvascular alterations in SSc, which are an expression of the systemic vascular changes characteristic of this disease...
December 2010: Joint, Bone, Spine: Revue du Rhumatisme
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