Oluwatosin Y Ibhagui, Dongjun Li, Hongwei Han, Guangda Peng, Maureen L Meister, Zongxiang Gui, Jingjuan Qiao, Mani Salarian, Bin Dong, Yi Yuan, Yiting Xu, Hua Yang, Shanshan Tan, Ganesh Satyanarayana, Shenghui Xue, Ravi Chakra Turaga, Malvika Sharma, Yan Hai, Yuguang Meng, Khan Hekmatyar, Phillip Sun, Gabriel Sica, Xiangming Ji, Zhi-Ren Liu, Jenny J Yang
Chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), are major leading causes of death worldwide and are generally associated with poor prognoses. The heterogeneous distribution of collagen, mainly type I collagen associated with excessive collagen deposition, plays a pivotal role in the progressive remodeling of the lung parenchyma to chronic exertional dyspnea for both IPF and COPD. To address the pressing need for noninvasive early diagnosis and drug treatment monitoring of pulmonary fibrosis, we report the development of human collagen-targeted protein MRI contrast agent (hProCA32...
June 26, 2023: Chem Biomed Eng