D P Aksenov, K Rutila, L Li, M J Miller, D A Gascoigne, N A Serdyukova, E D Doubovikov, R A Linsenmeier, A Drobyshevsky
Localized increases in neuronal activity are supported by the hemodynamic response, which delivers oxygen to the brain tissue to support synaptic functions, action potentials and other neuronal processes. However, it remains unknown if changes in baseline neuronal activity, which are expected to reflect neuronal metabolic demand, alter the relationship between the local hemodynamic and oxygen behaviour. In order to better characterize this system, we examine here the relationship between brain tissue oxygen (PO2 ) and hemodynamic responses (BOLD functional MRI) under different levels of neuronal activity...
2023: Advances in Experimental Medicine and Biology