keyword
MENU ▼
Read by QxMD icon Read
search

outer hair cell

keyword
https://www.readbyqxmd.com/read/28538522/frequency-specificity-and-left-ear-advantage-of-medial-olivocochlear-efferent-modulation-a-study-based-on-stimulus-frequency-otoacoustic-emission
#1
Dongjia Xing, Qin Gong
The medial olivocochlear (MOC) bundle is an auditory nucleus that projects efferent nerve fibers to the outer hair cells (OHCs) for synaptic innervation. The aim of the present study was to investigate the possible existence of frequency and ear specificity in MOC efferent modulation, as well as how MOC activation influences cochlear tuning. Stimulus frequency otoacoustic emissions (SFOAEs) were used to study MOC efferent modulation. Therefore, the current experiment was designed to compare the degree of SFOAE suppression in the both ears of 20 individuals at 1, 2, 4, and 8 kHz...
May 19, 2017: Neuroreport
https://www.readbyqxmd.com/read/28537102/cisplatin-induced-metabolome-changes-in-serum-an-experimental-approach-to-identify-markers-for-ototoxicity
#2
Pernilla Videhult Pierre, Jakob Haglöf, Birgitta Linder, Mikael K R Engskog, Torbjörn Arvidsson, Curt Pettersson, Anette Fransson, Göran Laurell
BACKGROUND: Ototoxicity from treatment with the anticancer drug cisplatin remains a clinical problem. A wide range of intracellular targets of cisplatin has been found in vivo. AIM: To investigate cisplatin-induced change of the serum metabolite profile and its association with ototoxicity. MATERIAL AND METHODS: Guinea pigs (n = 14) were treated with cisplatin (8 mg/kg b.w., i.v.) 30 min after administration of the otoprotector candidate sodium thiosulfate (group STS; n = 7) or sodium chloride (group NaCl; n = 7)...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28534946/differentiation-of-nestin%C3%A2-negative-human-hair-follicle-outer-root-sheath-cells-into-neurons-in%C3%A2-vitro
#3
Wei Wu, Xiao-Li Wu, Yu-Qing Ji, Zhen Gao
A specialized quiescent population of hair follicle stem cells, residing in the hair follicle outer root sheath cells (ORSCs), has previously demonstrated pluripotency for differentiation into neural stem cells (NSCs). A previous study indicated that nestin‑positive hair follicle ORSCs are able to differentiate into neurons. However, little has been reported on the isolation of nestin‑negative human ORSCs and whether they can successfully differentiate into neurons in vitro. In the present study, nestin‑positive ORSCs were significantly reduced with a prolonged incubation time in vitro...
May 16, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28532435/early-growth-response-protein-1-regulates-promoter-activity-of-%C3%AE-plasma-membrane-calcium-atpase-2-a-major-calcium-pump-in-the-brain-and-auditory-system
#4
Rebecca R Minich, Jin Li, Bruce L Tempel
BACKGROUND: Along with sodium/calcium (Ca(2+)) exchangers, plasma membrane Ca(2+) ATPases (ATP2Bs) are main regulators of intracellular Ca(2+) levels. There are four ATP2B paralogs encoded by four different genes. Atp2b2 encodes the protein pump with the fastest activation, ATP2B2. In mice, the Atp2b2 transcript has several alternate transcriptional start site variants: α, β, µ and δ. These variants are expressed in developmental and tissue specific manners. The α and β Atp2b2 transcripts are equally expressed in the brain...
May 22, 2017: BMC Molecular Biology
https://www.readbyqxmd.com/read/28505495/generalized-boussinesq-scriven-surface-fluid-model-with-curvature-dissipation-for-liquid-surfaces-and-membranes
#5
Oscar F Aguilar Gutierrez, Edtson E Herrera Valencia, Alejandro D Rey
Curvature dissipation is relevant in synthetic and biological processes, from fluctuations in semi-flexible polymer solutions, to buckling of liquid columns, tomembrane cell wall functioning. We present a micromechanical model of curvature dissipation relevant to fluid membranes and liquid surfaces based on a parallel surface parameterization and a stress constitutive equation appropriate for anisotropic fluids and fluid membranes.The derived model, aimed at high curvature and high rate of change of curvature in liquid surfaces and membranes, introduces additional viscous modes not included in the widely used 2D Boussinesq-Scriven rheological constitutive equation for surface fluids...
May 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28503132/protecting-mammalian-hair-cells-from-aminoglycoside-toxicity-assessing-phenoxybenzamine-s-potential
#6
Paromita Majumder, Paulette A Moore, Guy P Richardson, Jonathan E Gale
Aminoglycosides (AGs) are widely used antibiotics because of their low cost and high efficacy against gram-negative bacterial infection. However, AGs are ototoxic, causing the death of sensory hair cells in the inner ear. Strategies aimed at developing or discovering agents that protect against aminoglycoside ototoxicity have focused on inhibiting apoptosis or more recently, on preventing antibiotic uptake by the hair cells. Recent screens for ototoprotective compounds using the larval zebrafish lateral line identified phenoxybenzamine as a potential protectant for aminoglycoside-induced hair cell death...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28484373/evolution-and-development-of-the-inner-ear-efferent-system-transforming-a-motor-neuron-population-to-connect-to-the-most-unusual-motor-protein-via-ancient-nicotinic-receptors
#7
REVIEW
Bernd Fritzsch, Karen L Elliott
All craniate chordates have inner ears with hair cells that receive input from the brain by cholinergic centrifugal fibers, the so-called inner ear efferents (IEEs). Comparative data suggest that IEEs derive from facial branchial motor (FBM) neurons that project to the inner ear instead of facial muscles. Developmental data showed that IEEs develop adjacent to FBMs and segregation from IEEs might depend on few transcription factors uniquely associated with IEEs. Like other cholinergic terminals in the peripheral nervous system (PNS), efferent terminals signal on hair cells through nicotinic acetylcholine channels, likely composed out of alpha 9 and alpha 10 units (Chrna9, Chrna10)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28484004/maturation-arrest-in-early-postnatal-sensory-receptors-by-deletion-of-the-mir-183-96-182-cluster-in-mouse
#8
Jianguo Fan, Li Jia, Yan Li, Seham Ebrahim, Helen May-Simera, Alynda Wood, Robert J Morell, Pinghu Liu, Jingqi Lei, Bechara Kachar, Leonardo Belluscio, Haohua Qian, Tiansen Li, Wei Li, Graeme Wistow, Lijin Dong
The polycistronic miR-183/96/182 cluster is preferentially and abundantly expressed in terminally differentiating sensory epithelia. To clarify its roles in the terminal differentiation of sensory receptors in vivo, we deleted the entire gene cluster in mouse germline through homologous recombination. The miR-183/96/182 null mice display impairment of the visual, auditory, vestibular, and olfactory systems, attributable to profound defects in sensory receptor terminal differentiation. Maturation of sensory receptor precursors is delayed, and they never attain a fully differentiated state...
May 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28479241/ototoxicity-of-boric-acid-powder-in-a-rat-animal-model
#9
Murat Salihoglu, Salim Dogru, Enver Cesmeci, Halil Caliskan, Onuralp Kurt, Zafer Kuçukodaci, Atila Gungor
INTRODUCTION: Boric acid, which has antiseptic and acidic properties, is used to treat external and middle ear infections. However, we have not found any literature about the effect of boric acid powder on middle ear mucosa and inner ear. OBJECTIVE: The purpose of this study is to investigate possible ototoxic effects of boric acid powder (BAP) on cochlear outer hair cell function and histological changes in middle ear mucosa in a rat animal model. METHODS: Twenty healthy, mature Wistar albino rats were used in this study...
April 22, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28471702/adeno-associated-virus-transformation-into-the-normal-miniature-pig-and-the-normal-guinea-pigs-cochlea-via-scala-tympani
#10
Xunbei Shi, Nan Wu, Yue Zhang, Weiwei Guo, Chang Lin, Shiming Yang
OBJECTIVE: To investigate the expression of the miniature pig cochlea after AAV1 transfect into the cochlea via round window membrane (RWM). METHODS: Twenty miniature pigs are equally divided into four experimental groups. Twelve miniature pigs are equally divided into four control groups. Each pig was transfected with the AAV1 in the experimental group via RWM and each pig was transduced with the artificial perilymph in the control group. The expression of green fluorescent protein (GFP) was observed at 2 weeks, 3 weeks and 4 weeks, respectively...
May 4, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28460251/streptococcus-pneumoniae-induced-ototoxicity-in-organ-of-corti-explant-cultures
#11
Michael Perny, Magdalena Solyga, Denis Grandgirard, Marta Roccio, Stephen L Leib, Pascal Senn
Hearing loss remains the most common long-term complication of pneumococcal meningitis (PM) reported in up to 30% of survivors. Streptococcus pneumoniae have been shown to possess different ototoxic properties. Here we present a novel ex vivo experimental setup to examine in detail the pattern of hair cell loss upon exposure to different S. pneumoniae strains, therefore recapitulating pathogen derived aspects of PM-induced hearing loss. Our results show a higher susceptibility towards S. pneumoniae-induced cochlear damage for outer hair cells (OHC) compared to inner hair cells (IHC), which is consistent with in vivo data...
April 25, 2017: Hearing Research
https://www.readbyqxmd.com/read/28439223/outer-hair-cell-and-auditory-nerve-function-in-speech-recognition-in-quiet-and-in-background-noise
#12
Richard Hoben, Gifty Easow, Sofia Pevzner, Mark A Parker
The goal of this study was to describe the contribution of outer hair cells (OHCs) and the auditory nerve (AN) to speech understanding in quiet and in the presence of background noise. Fifty-three human subjects with hearing ranging from normal to moderate sensorineural hearing loss were assayed for both speech in quiet (Word Recognition) and speech in noise (QuickSIN test) performance. Their scores were correlated with OHC function as assessed via distortion product otoacoustic emissions, and AN function as measured by amplitude, latency, and threshold of the VIIIth cranial nerve Compound Action Potential (CAP) recorded during electrocochleography (ECochG)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28437273/assessing-sensorineural-hearing-loss-using-various-transient-evoked-otoacoustic-emission-stimulus-conditions
#13
Daniel B Putterman, Douglas H Keefe, Lisa L Hunter, Angela C Garinis, Denis F Fitzpatrick, Garnett P McMillan, M Patrick Feeney
OBJECTIVES: An important clinical application of transient-evoked otoacoustic emissions (TEOAEs) is to evaluate cochlear outer hair cell function for the purpose of detecting sensorineural hearing loss (SNHL). Double-evoked TEOAEs were measured using a chirp stimulus, in which the stimuli had an extended frequency range compared to clinical tests. The present study compared TEOAEs recorded using an unweighted stimulus presented at either ambient pressure or tympanometric peak pressure (TPP) in the ear canal and TEOAEs recorded using a power-weighted stimulus at ambient pressure...
April 21, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28432353/severe-hearing-loss-and-outer-hair-cell-death-in-homozygous-foxo3-knockout-mice-after-moderate-noise-exposure
#14
Felicia Gilels, Stephen T Paquette, Holly J Beaulac, Anwen Bullen, Patricia M White
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL. The transcription factor Foxo3 integrates the cellular response to oxidative stress and plays a role in extending lifespan in many organisms, including humans. Here we show that Foxo3 is required for auditory function after noise exposure in a mouse model system, measured by ABR. Absent Foxo3, outer hair cells are lost throughout the middle and higher frequencies...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28422190/current-carried-by-the-slc26-family-member-prestin-does-not-flow-through-the-transporter-pathway
#15
Jun-Ping Bai, Iman Moeini-Naghani, Sheng Zhong, Fang-Yong Li, Shumin Bian, Fred J Sigworth, Joseph Santos-Sacchi, Dhasakumar Navaratnam
Prestin in the lateral membrane of outer hair cells, is responsible for electromotility (EM) and a corresponding nonlinear capacitance (NLC). Prestin's voltage sensitivity is influenced by intracellular chloride. A regulator of intracellular chloride is a stretch-sensitive, non-selective conductance within the lateral membrane, GmetL. We determine that prestin itself possesses a stretch-sensitive, non-selective conductance that is largest in the presence of thiocyanate ions. This conductance is independent of the anion transporter mechanism...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420960/contralateral-inhibition-of-click-and-chirp-evoked-human-compound-action-potentials
#16
Spencer B Smith, Jeffery T Lichtenhan, Barbara K Cone
Cochlear outer hair cells (OHC) receive direct efferent feedback from the caudal auditory brainstem via the medial olivocochlear (MOC) bundle. This circuit provides the neural substrate for the MOC reflex, which inhibits cochlear amplifier gain and is believed to play a role in listening in noise and protection from acoustic overexposure. The human MOC reflex has been studied extensively using otoacoustic emissions (OAE) paradigms; however, these measurements are insensitive to subsequent "downstream" efferent effects on the neural ensembles that mediate hearing...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28420953/using-cochlear-microphonic-potentials-to-localize-peripheral-hearing-loss
#17
Karolina K Charaziak, Christopher A Shera, Jonathan H Siegel
The cochlear microphonic (CM) is created primarily by the receptor currents of outer hair cells (OHCs) and may therefore be useful for identifying cochlear regions with impaired OHCs. However, the CM measured across the frequency range with round-window or ear-canal electrodes lacks place-specificity as it is dominated by cellular sources located most proximal to the recording site (e.g., at the cochlear base). To overcome this limitation, we extract the "residual" CM (rCM), defined as the complex difference between the CM measured with and without an additional tone (saturating tone, ST)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28418107/a-new-path-in-defining-light-parameters-for-hair-growth-discovery-and-modulation-of-photoreceptors-in-human-hair-follicle
#18
Serena Buscone, Andrei N Mardaryev, Bianca Raafs, Jan W Bikker, Carsten Sticht, Norbert Gretz, Nilofer Farjo, Natallia E Uzunbajakava, Natalia V Botchkareva
BACKGROUND AND OBJECTIVE: Though devices for hair growth based on low levels of light have shown encouraging results, further improvements of their efficacy is impeded by a lack of knowledge on the exact molecular targets that mediate physiological response in skin and hair follicle. The aim of this study was to investigate the expression of selected light-sensitive receptors in the human hair follicle and to study the impact of UV-free blue light on hair growth ex vivo. MATERIAL AND METHODS: The expression of Opsin receptors in human skin and hair follicles has been characterized using RT-qPCR and immunofluorescence approaches...
April 18, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28415260/enhanced-processing-in-arrays-of-optimally-tuned-nonlinear-biomimetic-sensors-a-coupling-mediated-ringelmann-effect-and-its-dynamical-mitigation
#19
Alexander P Nikitin, Adi R Bulsara, Nigel G Stocks
Inspired by recent results on self-tunability in the outer hair cells of the mammalian cochlea, we describe an array of magnetic sensors where each individual sensor can self-tune to an optimal operating regime. The self-tuning gives the array its "biomimetic" features. We show that the overall performance of the array can, as expected, be improved by increasing the number of sensors but, however, coupling between sensors reduces the overall performance even though the individual sensors in the system could see an improvement...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28414275/a-new-hypothesis-on-the-frequency-discrimination-of-the-cochlea
#20
Erdoğan Bulut, Cem Uzun, Levent Öztürk, Pınar Turan, Mehmet Kanter, Serap Arbak
OBJECTIVE: Medial olivocochlear efferent (MOCE) neurons innervate outer hair cells (OHCs) of the cochlea, which in turn leads to basilar membrane motion. We hypothesized that MOCE-induced alterations in basilar membrane motion, independent of traveling waves, is responsible for the cochlear frequency discrimination of sound. MATERIALS AND METHODS: Eleven guinea pigs underwent bilateral otoscopic and audiologic evaluations under general anesthesia. The study comprised two parts...
April 17, 2017: Journal of International Advanced Otology
keyword
keyword
79550
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"