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Antireflux mucosectomy

Robert Bechara, Haruhiro Inoue
Over the past 30 years, the field of endoscopy has witnessed several advances. With the advent of endoscopic mucosal resection, removal of large mucosal lesions have become possible. Thereafter, endoscopic submucosal resection was refined, permitting en bloc removal of large superficial neoplasms. Such techniques have facilitated the development of antireflux mucosectomy, a promising novel treatment for gastroesophageal reflux. The introduction and use of over the scope clips has allowed for endoscopic closure of defects in the gastrointestinal tract, which were traditionally treated with surgical intervention...
May 16, 2015: World Journal of Gastrointestinal Endoscopy
René Aujeský, Cestmír Neoral, Radek Vrba, Martin Stašek, Katherine Vomáčková
INTRODUCTION: Barrett's esophagus is the most significant precancer of the esophagus. Its malignization gives rise to most adenocarcinomas of the esophagus. Therefore selection of adequate therapy for this precancerous condition is of the utmost importance. AIM: The authors of the work addressed the question of whether effective therapy of reflux disease alone may halt the process of malignization of Barrett's mucosa or even cause its regression. MATERIAL AND METHODS: The analyzed set comprised 50 patients with Barrett's esophagus, who in 48 cases underwent laparoscopic fundoplication and in two cases underwent an indirect antireflux procedure in the form of gastric resection with a Roux-en-Y gastrojejunal anastomosis...
June 2014: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
A H Hölscher, D Vallböhmer, C Gutschow, E Bollschweiler
INTRODUCTION: Because of the increasing frequency of Barrett's cancer in Western industrialized countries, the management of reflux disease with the potential development of Barrett's esophagus, neoplasia, and early carcinoma is very important. In case of established Barrett's esophagus, the malignant degeneration of the specialized epithelium cannot definitely be prevented by antireflux surgery or continuous medication. Mucosal adenocarcinomas nearly never develop lymph node metastasis and can mostly be treated by endoscopic mucosectomy...
May 2009: Langenbeck's Archives of Surgery
A H Hölscher, E Bollschweiler, C Gutschow
Esophagitis, ulcer with potential for bleeding and peptic stenosis are typical complications of gastroesophageal reflux disease (GERD). Whereas GERD is frequent with symptom prevalence of 30 % in the normal population, ulcer and peptic stenosis have become very rare. Consequently surgical interventions due to these complications are only necessary in exceptional cases. After successful bougienage and response to adequate medical treatment, surgical indications for peptic stenosis or ulcer are not different to those for other forms of reflux disease...
November 2007: Zeitschrift Für Gastroenterologie
Oliviu Pascu, Monica Lencu
Barrett's esophagus is an alteration of the esophageal epithelium, regardless of length, evidenced by endoscopic examination (protrusion of the gastric mucosa into the esophagus in the shape of a flame) and confirmed by histological examination of the bioptic samples (intestinal metaplasia with mucosecretory cells). It develops following long-term gastro-esophageal reflux (GER). The documented risk factors are: long-term GER (duration more than 5 years), age over 50 years, male sex, Caucasian race, aggressiveness of the refluxed material, individual susceptibility of the esophageal mucosa to the refluxed material...
September 2004: Romanian Journal of Gastroenterology
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