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https://www.readbyqxmd.com/read/28527171/lymphocytic-hypophysitis-mimicking-pituitary-macroadenoma
#1
Tarun Kumar Ralot, Jitesh Aggarwal, Raghavendra Haniadka, Kushal Gehlot, Nikhil Dongre, Swapnil Patil
Lymphocytic hypophysitis is an inflammatory /autoimmune disorder that primarily involves the pituitary gland and the pituitary stalk. The common clinical presentations include headache, nausea, vomiting, fatigue, features of hypopituitarism and diabetes insipidus as well as diplopia, orbital pain and bitemporal hemianopia. We report a case of lymphocytic hypophysitis which presented as hemichorea. Neuroimaging showed a mass in the sella tursica region which, on histopathological examination was suggestive of lymphocytic hypophysitis...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28526958/-ectopic-suprasellar-type-iia-prl-secreting-pituitary-adenoma
#2
REVIEW
Heng-Jun Zhou, De-Sheng Pan, Xiao-Qun Ba, Ren-Ya Zhan, Xiu-Jue Zheng, Yue-Hui Ma
BACKGROUND: Ectopic pituitary adenomas (EPAs) are rare, and the suprasellar cistern seems to be the most common location. At this time, no detailed original classification, diagnosis, or treatment protocols for suprasellar pituitary adenomas (SPAs) have been described. CASE DESCRIPTION: A 19-year-old man showed visual disturbances and lack of libido for 3 years, he suffered a sharp decline in vision with only light perception in the last week. Magnetic resonance imaging scans revealed a large suprasellar cystic lesion with a normal pituitary in the sella turcica...
May 19, 2017: Pituitary
https://www.readbyqxmd.com/read/28523651/microstructure-and-nanomechanical-properties-of-single-stalks-from-diatom-didymosphenia-geminata-and-their-change-due-to-adsorption-of-selected-metal-ions
#3
Izabela Zgłobicka, Adrian Chlanda, Michał Woźniak, Maciej Łojkowski, Robert Szoszkiewicz, Marta Mazurkiewicz-Pawlicka, Wojciech Święszkowski, Elżbieta Wyroba, Krzysztof J Kurzydłowski
We present topographical and nanomechanical characterization of single Didymosphenia geminata stalks. We compared the samples before and after adsorption of metal ions from fresh water samples. Transmission electron microscopy studies of single stalks cross-sections have shown three distinct layers and an additional thin extra coat on the external layer (called here "EL"). Using scanning electron microscopy and atomic force microscopy (AFM) we found that topography of single stalks after ionic adsorption differs significantly from topography of pristine stalks...
May 18, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28522839/fast-diffusion-of-domesticated-maize-to-temperate-zones
#4
Xiaolong Li, Yinqiao Jian, Chuanxiao Xie, Jun Wu, Yunbi Xu, Cheng Zou
Adaptation to a temperate climate was a prerequisite for the spread of maize across a broad geographical range. To explicitly explore the demographic process underlying maize adaptation, we used a diffusion-based method to model the differentiation between temperate and tropical populations using the Non-Stiff Stalk group as a proxy for temperate maize. Based on multiple sequential Markovian coalescent approaches, we estimate that tropical and temperate maize diverged approximately 3'000 to 5'000 years ago and the population size shrank after the split...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522140/membrane-fusion-stalks-and-lipid-rafts-a-love-hate-relationship
#5
Herre Jelger Risselada
Coarse-grained molecular dynamics simulations are applied to explore the experimentally observed ability of the liquid-ordered (lo)/liquid-disordered (ld) phase boundary to facilitate viral membrane fusion. Surprisingly, a formed fusion stalk can be both attracted (i.e., stalkophilic) and repelled (i.e., stalkophobic) by the lo/ld phase boundary. The phase boundary becomes stalkophilic if the lo phase constituents have the larger negative spontaneous curvature. In such a case, location of the highly curved stalk near the less-ordered and thus (relatively) softer boundary region becomes energetically favorable...
May 15, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28514451/structure-of-the-full-length-glucagon-class-b-g-protein-coupled-receptor
#6
Haonan Zhang, Anna Qiao, Dehua Yang, Linlin Yang, Antao Dai, Chris de Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, Hui Zhang, Gye Won Han, Thomas D Grant, Raymond G Sierra, Uwe Weierstall, Garrett Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiaoqing Cai, Guangyao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, Patrick R Griffin, Jesper Lau, Vadim Cherezov, Huaiyu Yang, Michael A Hanson, Raymond C Stevens, Qiang Zhao, Hualiang Jiang, Ming-Wei Wang, Beili Wu
The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes. Here we report the 3.0 Å crystal structure of full-length GCGR containing both the extracellular domain and transmembrane domain in an inactive conformation. The two domains are connected by a 12-residue segment termed the stalk, which adopts a β-strand conformation, instead of forming an α-helix as observed in the previously solved structure of the GCGR transmembrane domain...
May 17, 2017: Nature
https://www.readbyqxmd.com/read/28512463/allometric-models-for-predicting-aboveground-biomass-and-carbon-stock-of-tropical-perennial-c4-grasses-in-hawaii
#7
Adel H Youkhana, Richard M Ogoshi, James R Kiniry, Manyowa N Meki, Mae H Nakahata, Susan E Crow
Biomass is a promising renewable energy option that provides a more environmentally sustainable alternative to fossil resources by reducing the net flux of greenhouse gasses to the atmosphere. Yet, allometric models that allow the prediction of aboveground biomass (AGB), biomass carbon (C) stock non-destructively have not yet been developed for tropical perennial C4 grasses currently under consideration as potential bioenergy feedstock in Hawaii and other subtropical and tropical locations. The objectives of this study were to develop optimal allometric relationships and site-specific models to predict AGB, biomass C stock of napiergrass, energycane, and sugarcane under cultivation practices for renewable energy and validate these site-specific models against independent data sets generated from sites with widely different environments...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28511077/clinical-and-laboratory-parameters-predicting-a-requirement-for-the-reevaluation-of-growth-hormone-status-during-growth-hormone-treatment-retesting-early-in-the-course-of-gh-treatment
#8
Dogus Vuralli, E Nazli Gonc, Z Alev Ozon, Ayfer Alikasifoglu, Nurgun Kandemir
OBJECTIVE: We aimed to define the predictive criteria, in the form of specific clinical, hormonal and radiological parameters, for children with growth hormone deficiency (GHD) who may benefit from the reevaluation of GH status early in the course of growth hormone (GH) treatment. DESIGN AND METHODS: Two hundred sixty-five children with growth hormone deficiency were retested by GH stimulation at the end of the first year of GH treatment. The initial clinical and laboratory characteristics of those with a normal (GH≥10ng/ml) response and those with a subnormal (GH<10ng/ml) response were compared to predict a normal GH status during reassessment...
May 10, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28507163/ca-2-binding-to-f-atp-synthase-%C3%AE-subunit-triggers-the-mitochondrial-permeability-transition
#9
Valentina Giorgio, Victoria Burchell, Marco Schiavone, Claudio Bassot, Giovanni Minervini, Valeria Petronilli, Francesco Argenton, Michael Forte, Silvio Tosatto, Giovanna Lippe, Paolo Bernardi
F-ATP synthases convert the electrochemical energy of the H(+) gradient into the chemical energy of ATP with remarkable efficiency. Mitochondrial F-ATP synthases can also undergo a Ca(2+)-dependent transformation to form channels with properties matching those of the permeability transition pore (PTP), a key player in cell death. The Ca(2+) binding site and the mechanism(s) through which Ca(2+) can transform the energy-conserving enzyme into a dissipative structure promoting cell death remain unknown. Through in vitro, in vivo and in silico studies we (i) pinpoint the "Ca(2+)-trigger site" of the PTP to the catalytic site of the F-ATP synthase β subunit and (ii) define a conformational change that propagates from the catalytic site through OSCP and the lateral stalk to the inner membrane...
May 15, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28506998/fgf10-sox9-are-essential-for-establishment-of-distal-progenitor-cells-during-salivary-gland-development
#10
Lemonia Chatzeli, Marcia Gaete, Abigail S Tucker
Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk region) identities that produce the acini and higher order ducts respectively. Little is known about the factors that regulate progenitor expansion and specialisation in the different parts of the gland. Here we show that Sox9 is involved in establishing the identity of the distal compartment before the initiation of branching morphogenesis...
May 15, 2017: Development
https://www.readbyqxmd.com/read/28503686/mesoporous-nanocarriers-with-a-stimulus-responsive-cyclodextrin-gatekeeper-for-targeting-tumor-hypoxia
#11
Jeonghun Lee, Eun-Taex Oh, Haerry Yoon, Chan Woo Kim, Yeji Han, Jaehun Song, Hyunil Jang, Heon Joo Park, Chulhee Kim
Tissue hypoxia developed in most malignant tumors makes a significant difference to normal tissues in the reduction potential and the activity of various bioreductive enzymes. Given the superior enzymatic activity of NAD(P)H:quinone oxidoreductase 1 (NQO1, a cytosolic reductase up-regulated in many human cancers) in hypoxia relative to that in normoxia, NQO1 has great potential for targeting hypoxic tumor cells. In the present report, the core concept of hypoxic NQO1-responsive mesoporous silica nanoparticles (MSNs) is based on the reasoning that the superior enzymatic activity of NQO1 within hypoxic cancer cells can be utilized as a key stimulus for the selective cleavage of an azobenzene stalk triggering the on-off gatekeeping for controlled release of guest drugs...
May 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28502779/microeukaryote-community-in-a-partial-nitritation-reactor-prior-to-anammox-and-an-insight-into-the-potential-of-ciliates-as-performance-bioindicators
#12
Oriol Canals, Ramon Massana, Joan Lluís Riera, Vanessa Balagué, Humbert Salvadó
An in-depth, long-term, multidisciplinary study was conducted in order to study the microeukaryote community in a partial nitritation (PN) reactor prior to anammox. The PN reactor operated with moving bed biofilm reactor (MBBR) technology, using plastic supports (carriers) for biofilm development. The microeukaryote community from the biofilm (BF) and the surrounding media (mixed liquor or ML) were analysed separately. Despite the physicochemical conditions under which the PN-MBBR operated (an average of 305...
May 11, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28500524/cytoskeletal-proteins-in-caulobacter-crescentus-spatial-orchestrators-of-cell-cycle-progression-development-and-cell-shape
#13
Kousik Sundararajan, Erin D Goley
Caulobacter crescentus, an aquatic Gram-negative α-proteobacterium, is dimorphic, as a result of asymmetric cell divisions that give rise to a free-swimming swarmer daughter cell and a stationary stalked daughter. Cell polarity of vibrioid C. crescentus cells is marked by the presence of a stalk at one end in the stationary form and a polar flagellum in the motile form. Progression through the cell cycle and execution of the associated morphogenetic events are tightly controlled through regulation of the abundance and activity of key proteins...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28496167/effect-of-trichoderma-harzianum-on-maize-rhizosphere-microbiome-and-biocontrol-of-fusarium-stalk-rot
#14
Kandasamy Saravanakumar, Yaqian Li, Chuanjin Yu, Qiang-Qiang Wang, Meng Wang, Jianan Sun, Jin-Xin Gao, Jie Chen
Fusarium stalk rot (FSR) caused by Fusarium graminearum (FG) significantly affects the productivity of maize grain crops. Application of agrochemicals to control the disease is harmful to environment. In this regard, use of biocontrol agent (BCA) is an alternative to agrochemicals. Although Trichoderma species are known as BCA, the selection of host-pathogen specific Trichoderma is essential for the successful field application. Hence, we screened a total of 100 Trichoderma isolates against FG, selected Trichoderma harzianum (CCTCC-RW0024) for greenhouse experiments and studied its effect on changes of maize rhizosphere microbiome and biocontrol of FSR...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28481510/chiral-at-metal-phosphorescent-square-planar-pt-ii-complexes-from-an-achiral-organometallic-ligand
#15
Thorben Rüdiger Schulte, Julian J Holstein, Lennard Krause, Reent Michel, Dietmar Stalke, Eri Sakuda, Keisuke Umakoshi, Giovanna Longhi, Sergio Abbate, Guido H Clever
The synthesis and characterization of a new kind of cis- and trans-cyclometalated square-planar platinum(II) com- plexes is reported. Uncharged organometallic compounds carrying one or two of the C^N-donor ligand LCN were prepared. Due to the heterobidentate coordination of the achiral chelate ligand, the formed [PtLCNCl(SEt2)], cis- and trans-[PtLCN2] complexes are chiral with the metal serving as the stereo center. The enantiomers of complex trans-[PtLCN2] could be separated and their absolute configuration was determined by anomalous X-ray diffraction, in accordance with CD spectroscopic results and TD-DFT calcula- tions...
May 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28472636/near-neighbor-interactions-of-the-membrane-embedded-subunits-of-the-mitochondrial-atp-synthase-of-a-chlorophycean-alga
#16
Lorenzo Sánchez-Vásquez, Miriam Vázquez-Acevedo, Javier de la Mora, Félix Vega-deLuna, Pierre Cardol, Claire Remacle, Georges Dreyfus, Diego González-Halphen
Mitochondrial F1FO-ATP synthase of the chlorophycean algae Polytomella sp. can be isolated as a highly stable dimeric complex of 1600kDa. It is composed of eight highly conserved orthodox subunits (α, β, γ, δ, ε, OSCP, a, and c) and nine subunits (Asa1-9) that are exclusive of chlorophycean algae. The Asa subunits replace those that build up the peripheral stalk and the dimerization domains of the ATP synthase in other organisms. Little is known about the disposition of subunits Asa6, Asa8 and Asa9, that are predicted to have transmembrane stretches and that along with subunit a and a ring of c-subunits, seem to constitute the membrane-embedded Fo domain of the algal ATP synthase...
May 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28470753/stalk-versus-base-invasion-in-pt1-papillary-cancers-of-the-bladder-improved-substaging-system-predicting-risk-of-progression
#17
Margaret Lawless, Roman Gulati, Maria Tretiakova
AIMS: Pathologic stage T1 (pT1) bladder cancers are a clinically heterogeneous group. However, current staging guidelines for superficially invasive cancers do not acknowledge the variability in type and extent of lamina propria invasion in papillary urothelial carcinomas (PUC), and historically proposed substaging systems showed either high inter-observer variation or limited value in predicting patient outcomes. Herein we reappraise pT1 PUC substaging, aiming to identify a novel scheme which is reproducible and prognostically meaningful...
May 4, 2017: Histopathology
https://www.readbyqxmd.com/read/28467151/prenatal-diagnosis-of-a-body-stalk-anomaly-by-a-combination-of-ultrasonography-and-foetal-magnetic-resonance-imaging
#18
Hiroto Ueda, Toshinobu Miyamoto, Gaku Minase, Kazuo Sengoku
No abstract text is available yet for this article.
May 3, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28467007/fsr1-a-striatin-homolog-forms-an-endomembrane-associated-complex-that-regulates-virulence-in-the-maize-pathogen-fusarium-verticillioides
#19
Huan Zhang, Mala Mukherjee, Jung-Eun Kim, Wenying Yu, Won-Bo Shim
Fsr1, a homolog of mammalian striatin, containing multiple protein-binding domains and a coiled-coil (CC) domain is critical for F. verticillioides virulence. In mammals, striatin interacts with multiple proteins to form a STRIPAK (striatin-interacting phosphatase and kinase) complex that regulates a variety of developmental processes and cellular mechanisms. In this study, we identified the homolog of a key mammalian STRIPAK component STRIP1/2 in F. verticillioides, FvStp1, that interacts with Fsr1 in vivo...
May 3, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28464079/effects-of-roughage-inclusion-and-particle-size-on-digestion-and-ruminal-fermentation-characteristics-of-beef-steers
#20
C P Weiss, W W Gentry, C M Meredith, B E Meyer, N A Cole, L O Tedeschi, F T McCollum, J S Jennings
Roughage is fed in finishing diets to promote ruminal health and decrease digestive upset, but the inclusion rate is limited because of the cost per unit of energy and feed management issues. Rumination behavior of cattle may be a means to standardize roughage in beef cattle finishing diets, and increasing the particle size of roughage could modulate the ruminal environment and aid in maintaining ruminal pH. Therefore, this experiment was conducted to determine the effects of corn stalk (CS) inclusion rate and particle size in finishing diets on digestibility, rumination, and ruminal fermentation characteristics of beef steers...
April 2017: Journal of Animal Science
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