Nicole R Provenza, Sameer A Sheth, Evan M Dastin-van Rijn, Raissa K Mathura, Yaohan Ding, Gregory S Vogt, Michelle Avendano-Ortega, Nithya Ramakrishnan, Noam Peled, Luiz Fernando Fracassi Gelin, David Xing, Laszlo A Jeni, Itir Onal Ertugrul, Adriel Barrios-Anderson, Evan Matteson, Andrew D Wiese, Junqian Xu, Ashwin Viswanathan, Matthew T Harrison, Kelly R Bijanki, Eric A Storch, Jeffrey F Cohn, Wayne K Goodman, David A Borton
Detection of neural signatures related to pathological behavioral states could enable adaptive deep brain stimulation (DBS), a potential strategy for improving efficacy of DBS for neurological and psychiatric disorders. This approach requires identifying neural biomarkers of relevant behavioral states, a task best performed in ecologically valid environments. Here, in human participants with obsessive-compulsive disorder (OCD) implanted with recording-capable DBS devices, we synchronized chronic ventral striatum local field potentials with relevant, disease-specific behaviors...
December 2021: Nature Medicine