keyword
https://read.qxmd.com/read/38476896/antibiotic-administration-aggravates-asthma-by-disrupting-gut-microbiota-and-the-intestinal-mucosal-barrier-in-an-asthma-mouse-model
#21
JOURNAL ARTICLE
Cheng-Ling Xu, Cui Wang, Gao-Bin Li, Tong Zhao, Rui-Ling Zhou, Jing Chen
In humans, gut microbiota can determine the health status. The regulatory mechanisms of the gut microbiota in asthma must be elucidated. Although antibiotics (ABXs) can clear infections, they markedly alter the composition and abundance of gut microbiota. The present study used ABX-treated mice to examine the time-dependent effects of ABX administration on the gut microbiota and intestinal mucosal barrier. The mouse asthma model was established using ovalbumin (OVA) and gavaged with an ABX cocktail for different durations (1 or 2 weeks) and stacked sequences...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38473902/quantifying-the-dynamics-of-bacterial-biofilm-formation-on-the-surface-of-soft-contact-lens-materials-using-digital-holographic-tomography-to-advance-biofilm-research
#22
JOURNAL ARTICLE
Igor Buzalewicz, Aleksandra Kaczorowska, Wojciech Fijałkowski, Aleksandra Pietrowska, Anna Karolina Matczuk, Halina Podbielska, Alina Wieliczko, Wojciech Witkiewicz, Natalia Jędruchniewicz
The increase in bacterial resistance to antibiotics in recent years demands innovative strategies for the detection and combating of biofilms, which are notoriously resilient. Biofilms, particularly those on contact lenses, can lead to biofilm-related infections (e.g., conjunctivitis and keratitis), posing a significant risk to patients. Non-destructive and non-contact sensing techniques are essential in addressing this threat. Digital holographic tomography emerges as a promising solution. This allows for the 3D reconstruction of the refractive index distribution in biological samples, enabling label-free visualization and the quantitative analysis of biofilms...
February 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472422/pharmacokinetics-and-pharmacodynamics-of-antibacterial-peptide-nzx-in-staphylococcus-aureus-mastitis-mouse-model
#23
JOURNAL ARTICLE
Xueling Zheng, Na Yang, Ruoyu Mao, Ya Hao, Da Teng, Jianhua Wang
Staphylococcus aureus is associated with dairy mastitis, which causes serious economic losses to dairy farming industry. Antibacterial peptide NZX showed good antibacterial activity against S. aureus. This study aimed to evaluate pharmacokinetics and pharmacodynamics of NZX against S. aureus-induced mouse mastitis. NZX exhibited potent in vitro antibacterial activity against the test S. aureus strains (minimal inhibitory concentration (MIC): 0.23-0.46 μM), low mutant prevention concentration (MPC: 1...
March 13, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38469835/indian-academy-of-pediatrics-consensus-statement-on-diagnosis-and-management-of-bone-and-joint-infections-in-children
#24
JOURNAL ARTICLE
Bhaskar Shenoy, Tanu Singhal, Vijay Yewale, Jaydeep Choudhury, Pragalatha Kumar A, Mandar V Agashe, Chandrashekhar Chikkamuniyappa, Seema Janardhan, Bakul Jayant Parekh, G V Basavaraja
JUSTIFICATION: Osteoarticular infections are fairly common in children but often these are associated with underdiagnosis, delayed diagnosis and improper management. This leads to an increased incidence of complications and poor outcomes. Given the paucity of standard protocols for the management of these children in the Indian context, Indian Academy of Pediatrics (IAP) has taken the initiative to formulate guidelines for the early diagnosis and rational management of bone and joint infections (BJIs)...
March 15, 2024: Indian Pediatrics
https://read.qxmd.com/read/38465428/marine-microalgae-schizochytrium-sp-s31-potential-source-for-new-antimicrobial-and-antibiofilm-agent
#25
JOURNAL ARTICLE
Doaa Abdullah Hammadi Al-Ogaidi, Sevinç Karaçam, Rafig Gurbanov, Nurcan Vardar-Yel
BACKGROUND: The rise of antibiotic-resistant bacteria necessitates the discovery of new, safe, and bioactive antimicrobial compounds. The antibacterial and antibiofilm activity of microalgae makes them a potential candidate for developing natural antibiotics to limit microbial infection in various fields. OBJECTIVE: This study aimed to analyze the antibacterial effect of the methanolic extract of Schizochytrium sp. S31 microalgae by broth microdilution and spot plate assays...
March 7, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38447565/two-stage-treatment-protocol-of-fungal-periprosthetic-hip-and-knee-joint-infections-the-clinical-experience-from-a-single-center-experience
#26
JOURNAL ARTICLE
J Xu, W Sun, Y Wang, H Jiang, H Ding, Q Cheng, N Bao, J Meng
PURPOSE OF THE STUDY: To evaluate the clinical results and safety of fungal periprosthetic joint Infections (fPJIs) using two-stage treatment protocol. MATERIAL AND METHODS: 8 patients with fPJIs (3 hips and 5 knees) using two-stage revision were reviewed retrospectively and followed up at least 2 years. The preoperative demographic data, two-stage treatment protocol, results of microbiology and histologic workup and postoperative follow-up results (reimplantation success rate and infection free time) were recorded...
2024: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://read.qxmd.com/read/38447454/urbanization-influences-the-indoor-transfer-of-airborne-antibiotic-resistance-genes-which-has-a-seasonally-dependent-pattern
#27
JOURNAL ARTICLE
Chang Zhao, Xinxin Liu, Haoxin Tan, Yucheng Bian, Muhammad Khalid, Aki Sinkkonen, Ari Jumpponen, Saeed Ur Rahman, Baoming Du, Nan Hui
Over the last few years, the cumulative use of antibiotics in healthcare institutions, as well as the rearing of livestock and poultry, has resulted in the accumulation of antibiotic resistance genes (ARGs). This presents a substantial danger to human health worldwide. The characteristics of airborne ARGs, especially those transferred from outdoors to indoors, remains largely unexplored in neighborhoods, even though a majority of human population spends most of their time there. We investigated airborne ARGs and mobile genetic element (MGE, IntI1), plant communities, and airborne microbiota transferred indoors, as well as respiratory disease (RD) prevalence using a combination of metabarcode sequencing, real-time quantitative PCR and questionnaires in 72 neighborhoods in Shanghai...
March 1, 2024: Environment International
https://read.qxmd.com/read/38441982/-in-vitro-activity-of-human-defensins-hnp-1-and-hbd-3-against-multidrug-resistant-eskape-gram-negatives-of-clinical-origin-and-selected-peptidoglycan-recycling-defective-mutants
#28
JOURNAL ARTICLE
María Escobar-Salom, Isabel María Barceló, Estrella Rojo-Molinero, Elena Jordana-Lluch, Gabriel Cabot, Antonio Oliver, Carlos Juan
UNLABELLED: The use of immune compounds as antimicrobial adjuvants is a classic idea recovering timeliness in the current antibiotic resistance scenario. However, the activity of certain antimicrobial peptides against ESKAPE Gram-negatives has not been sufficiently investigated. The objective of this study was to determine the activities of human defensins HNP-1 and hBD-3 alone or combined with permeabilizing/peptidoglycan-targeting agents against clinical ESKAPE Gram-negatives [ Acinetobacter baumannii (AB), Enterobacter cloacae (EC), Klebsiella pneumoniae (KP), and acute/chronic Pseudomonas aeruginosa (PA)]...
March 5, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38439725/neutrophilic-dermatosis-of-the-hands-a-case-report
#29
JOURNAL ARTICLE
Reza Yaghoobi, Nooshin Bagherani, Bruce R Smoller, Nader Pazyar
Neutrophilic dermatosis of the hands (NDDH) is a localized variant of Sweet's syndrome which has been recently introduced. Strutton et al.in 1996 and then in Galaria et al. in 2000 reported cases with violaceous papulonodules on the dorsal surfaces of the hands with histopathological findings of a neutrophilic dermatosis in association with leukocytoclasia, but clinically and histologically without true vasculitis findings. Eventually, they proposed the term NDDH for these lesions (1,2). A 46-year-old man was referred to our outpatient dermatology clinic with a painful ulcerative lesion on the dorsal side of the left hand that had been present for one year...
December 2023: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/38433781/model-informed-precision-dosing-of-imipenem-in-an-obese-adolescent-patient-with-augmented-renal-clearance-and-history-of-schizophrenia
#30
Yueliang Chen, Yun Han, Feng Guo, Zhenwei Yu
Imipenem is a broad-spectrum antibiotic that has been used in treating severe infections and exhibits a time-dependent PK/PD profile. Its dose should be adjusted based on renal function. However, there is little experience with imipenem dosing in obese adolescent patients with augmented renal clearance (ARC) and history of schizophrenia. This case reported successful dosing of imipenem in an obese adolescent patient with ARC based on therapeutic drug monitoring (TDM) and model-informed precision dosing (MIPD)...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38432556/antimicrobial-photodynamic-effect-of-the-photosensitizer-riboflavin-alone-and-in-combination-with-colistin-against-pandrug-resistant-pseudomonas-aeruginosa-clinical-isolates
#31
JOURNAL ARTICLE
Ehsan Najari, Samin Zamani, Mehdi Sheikh Arabi, Abdollah Ardebili
INTRODUCTION: Development of multi-, extensively-, and pandrug-resistant (MDR, XDR, and PDR) strains of Pseudomonas aeruginosa remains a major problem in medical care. The present study evaluated the effect of antimicrobial photodynamic therapy (aPDT) as a monotherapy and in combination with colistin against P. aeruginosa isolates. METHODS: Two P. aeruginosa isolates recovered from patients with respiratory tract infections were examined in this study. Minimum inhibitory concentration (MIC) of colistin was determined by the colistin broth disk elution (CBDE) and the reference broth microdilution (rBMD) methods...
March 1, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38430797/in-vitro-effects-of-different-ozone-preparations-on-microorganisms-responsible-for-endometritis-in-the-mare
#32
JOURNAL ARTICLE
Gian Guido Donato, Patrizia Nebbia, Maria Cristina Stella, Daniela Scalas, Denis Necchi, Alessia Bertero, Giovanna Romano, Lara Bergamini, Mariagrazia Lucia Poletto, Andrea Peano, Patrizia Robino, Tiziana Nervo
Infectious endometritis is considered one of the major causes of infertility and it can affect up to 60% of barren mares. It is characterized by the presence of one or more microorganisms in the reproductive tract and it is treated with the administration of antibiotics, ecbolic agents and uterine lavages. Ozone, thanks to its antimicrobial properties that are based on its high oxidative potential, could represent an effective alternative treatment for endometritis. The aim of this study was to test in vitro the bactericidal and fungicidal properties of different ozone formulations, either as gas (experiment 1) or dissolved in two liquid matrices (experiment 2), specifically distilled water or oil (Neozone 4000, Cosmoproject, Parma, Italy), onto 6 different species of microorganisms isolated from mares with clinical endometritis, namely Escherichia coli, Staphylococcus aureus, Streptococcus equi subsp...
February 15, 2024: Theriogenology
https://read.qxmd.com/read/38426311/capturing-of-extracellular-vesicles-derived-from-single-cells-of-escherichia-coli
#33
JOURNAL ARTICLE
Fumiaki Yokoyama, André Kling, Petra S Dittrich
Bacteria secrete extracellular vesicles (EVs), also referred to as bacterial membrane vesicles, which carry, among other compounds, lipids, nucleic acids and virulence factors. Recent studies highlight the role of EVs in the emergence of antibiotic resistance, e.g. as carrier and absorbent particles of the drug to protect the cells, or as a pathway to disseminate resistance elements. In this study, we are interested in characterizing the secretion of EVs at the single bacterial level to ultimately understand how cells respond to antibiotic treatment...
March 1, 2024: Lab on a Chip
https://read.qxmd.com/read/38414395/development-of-a-model-to-predict-vancomycin-serum-concentration-during-continuous-infusion-of-vancomycin-in-critically-ill-pediatric-patients
#34
JOURNAL ARTICLE
Yu Jin Han, Wonjin Jang, Jung Sun Kim, Hyun Jeong Kim, Sung Yun Suh, Yoon Sook Cho, June Dong Park, Bongjin Lee
Vancomycin is a frequently used antibiotic in intensive care units, and the patient's renal clearance affects the pharmacokinetic characteristics of vancomycin. Several advantages have been reported for vancomycin continuous intravenous infusion, but studies on continuous dosing regimens based on patients' renal clearance are insufficient. The aim of this study was to develop a vancomycin serum concentration prediction model by factoring in a patient's renal clearance. Children admitted to our institution between July 1, 2021, and July 31, 2022 with records of continuous infusion of vancomycin were included in the study...
March 1, 2024: Korean Journal of Physiology & Pharmacology
https://read.qxmd.com/read/38412544/squamous-cell-carcinoma-of-the-supraglottis-presenting-as-hoarseness
#35
Tobe Momah, Olusegun Lijofi
Hoarseness is a well-known condition in primary care offices, with over 1% of primary care visits secondary to this ailment.1 The most common causes are acute laryngitis (40%), functional dysphonia (30%), benign and malignant tumors (2.2 to 30%), neurogenic factors such as vocal cord paralysis (8%), physiological aging (2%), and psychogenic factors (2.2%). Most of these cases are secondary to viral infections and do not require antibiotics on most occasions. These viral infections subside after 1 to 2 weeks, and in the case of persistent hoarseness (above 4 weeks) the American Academy of Otolaryngology recommends direct visualization with a laryngoscopy before treatment with proton pump inhibitors, antibiotics, or steroids...
January 31, 2024: West African Journal of Medicine
https://read.qxmd.com/read/38411952/ethambutol-and-meropenem-clavulanate-synergy-promotes-enhanced-extracellular-and-intracellular-killing-of-mycobacterium-tuberculosis
#36
JOURNAL ARTICLE
Francisco Olivença, David Pires, Cátia Silveiro, Bianca Gama, Frederico Holtreman, Elsa Anes, Maria João Catalão
Increasing evidence supports the repositioning of beta-lactams for tuberculosis (TB) therapy, but further research on their interaction with conventional anti-TB agents is still warranted. Moreover, the complex cell envelope of Mycobacterium tuberculosis ( Mtb ) may pose an additional obstacle to beta-lactam diffusion. In this context, we aimed to identify synergies between beta-lactams and anti-TB drugs ethambutol (EMB) and isoniazid (INH) by assessing antimicrobial effects, intracellular activity, and immune responses...
February 27, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38409503/unveiling-the-hidden-language-of-bacteria-anti-quorum-sensing-strategies-for-gram-negative-bacteria-infection-control
#37
REVIEW
Mahmoud A Elfaky
Quorum sensing (QS) is a communication mechanism employed by many bacteria to regulate gene expression in a population density-dependent manner. It plays a crucial role in coordinating various bacterial behaviors, including biofilm formation, virulence factor production, and antibiotic resistance. However, the dysregulation of QS can lead to detrimental effects, making it an attractive target for developing novel therapeutic strategies. Anti-QS approaches aim to interfere with QS signaling pathways, inhibiting the communication between bacteria, and disrupting their coordinated activities...
February 27, 2024: Archives of Microbiology
https://read.qxmd.com/read/38407513/catechol-siderophore-mimics-convey-nucleic-acid-therapeutics-into-bacteria
#38
JOURNAL ARTICLE
Mathijs Pals, Luuk Wijnberg, Caglar Yildiz, Willem A Velema
Antibacterial resistance is a major threat for human health. There is a need for new antibacterials to stay ahead of constantly-evolving resistant bacteria. Nucleic acid therapeutics hold promise as powerful antibiotics, but issues with their delivery hamper their applicability. Here, we exploit the siderophore-mediated iron uptake pathway to efficiently transport antisense oligomers into bacteria. We appended a synthetic siderophore to antisense oligomers targeting the essential acpP gene in Escherichia coli...
February 26, 2024: Angewandte Chemie
https://read.qxmd.com/read/38399370/antibacterial-and-anti-biofilm-efficacy-of-endolysin-lysab1245-against-a-panel-of-important-pathogens
#39
JOURNAL ARTICLE
Rosesathorn Soontarach, Potjanee Srimanote, Supayang Piyawan Voravuthikunchai, Sarunyou Chusri
Infections caused by antibiotic-resistant bacteria pose a significant global challenge. This study explores the antibacterial effects of a bacteriophage-derived endolysin, LysAB1245, against important pathogens, including Acinetobacter baumannii , Escherichia coli , Klebsiella pneumoniae , Pseudomonas aeruginosa, and Staphylococcus aureus. We determined the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) for all tested isolates. A time-kill study was conducted to evaluate the reduction in bacterial survival following treatment with LysAB1245...
January 25, 2024: Pharmaceuticals
https://read.qxmd.com/read/38399338/dysregulation-of-the-mrna-expression-of-human-renal-drug-transporters-by-proinflammatory-cytokines-in-primary-human-proximal-tubular-epithelial-cells
#40
JOURNAL ARTICLE
Yik Pui Tsang, Tianran Hao, Qingcheng Mao, Edward J Kelly, Jashvant D Unadkat
Proinflammatory cytokines, which are elevated during inflammation or infections, can affect drug pharmacokinetics (PK) due to the altered expression or activity of drug transporters and/or metabolizing enzymes. To date, such studies have focused on the effect of cytokines on the activity and/or mRNA expression of hepatic transporters and drug-metabolizing enzymes. However, many antibiotics and antivirals used to treat infections are cleared by renal transporters, including the basal organic cation transporter 2 (OCT2), organic anion transporters 1 and 3 (OAT1 and 3), the apical multidrug and toxin extrusion proteins 1 and 2-K (MATE1/2-K), and multidrug resistance-associated protein 2 and 4 (MRP2/4)...
February 16, 2024: Pharmaceutics
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