Yuge Zhuang, Wenyuan Liu, Feilong Chen, Minyu Xie, Hanbin Zhang, Zicong Huang, Xiaoyuan Zhang, Jinsheng Liu, Ke Ma, Hongrui Feng, Shipeng Ruan, Jing He, Wansong Zhang, Feng Zou, Xiangjin Kang, Yong Fan, Guofei Zhang, Zhenguo Chen
INTRODUCTION: Males with acute spinal cord injury (SCI) frequently exhibit testosterone deficiency and reproductive dysfunction. While such incidence rates are high in chronic patients, the underlying mechanisms remain elusive. METHODS AND RESULTS: Herein, we generated a rat SCI model, which recapitulated complications in human males, including low testosterone levels and spermatogenic disorders. Proteomics analyses showed that the differentially expressed proteins were mostly enriched in lipid metabolism and steroid metabolism and biosynthesis...
2024: Frontiers in Endocrinology