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https://www.readbyqxmd.com/read/28537907/sirt1-inhibition-promotes-atherosclerosis-through-impaired-autophagy
#1
Xiaofeng Yang, Jingyuan Wei, Yanhao He, Ting Jing, Yanxiang Li, Yunfang Xiao, Bo Wang, Weirong Wang, Jiye Zhang, Rong Lin
SIRT1, a highly conserved NAD+-dependent protein deacetylase, plays a pivotal role in the pathogenesis and therapy of atherosclerosis (AS). The aim of this study is to investigate the potential effects of SIRT1 on AS in ApoE-/- mice and the underlying mechanisms of autophagy in an ox-LDL-stimulated human monocyte cell line, THP-1. In vivo, the accelerated atherosclerotic progression of mice was established by carotid collar placement; then, mice were treated for 4 weeks with a SIRT1-specific inhibitor, EX-527...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28535354/high-capacity-and-ultrafast-na-ion-storage-of-self-supported-3d-porous-antimony-persulfide-graphene-foam-architecture
#2
Yanying Lu, Ning Zhang, Shuang Jiang, Yudong Zhang, Meng Zhou, Zhanliang Tao, Lynden A Archer, Jun Chen
The key challenge for high performance sodium-ion batteries is the exploitation of appropriate electrode materials with long cycling stability and high rate capability. Here, we report Sb2S5 nanoparticles (~ 5 nm) uniformly encapsulated in three-dimensional (3D) porous graphene foam, which were fabricated by a facile hydrothermal co-assembly strategy, as a high-performance anode material for sodium-ion batteries. The as-prepared composite can be directly used as electrodes without adding binder or current collector, exhibiting outstanding electrochemical performance with high reversible capacity (845 mAh g-1 at 0...
May 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28535047/electronic-and-morphological-dual-modulation-of-cobalt-carbonate-hydroxides-by-mn-doping-towards-highly-efficient-and-stable-bifunctional-electrocatalysts-for-overall-water-splitting
#3
Tang Tang, Wen-Jie Jiang, Shuai Niu, Ning Liu, Hao Luo, Yu-Yun Chen, Shi-Feng Jin, Feng Gao, Li-Jun Wan, Jin-Song Hu
Developing bifunctional non-noble electrocatalysts for efficient and durable oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is highly desirable and challenging for overall water splitting. Herein, Co-Mn carbonate hydroxide (CoMnCH) nanosheet arrays with controllable morphology and composition were developed on nickel foam (NF) as such bifunctional electrocatalysts. It was discovered that Mn doping in CoCH can simultaneously modulate the nanosheet morphology to significantly increase the electrochemical active surface area for exposing more accessible active sites and tune the electronic structure of Co center to effectively boost its intrinsic activity...
May 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28534609/au-promoted-nickel-iron-layered-double-hydroxide-nanoarrays-a-modular-catalyst-enabling-high-performance-oxygen-evolution
#4
Wenxin Zhu, Lizhi Liu, Zhihao Yue, Wentao Zhang, Xiaoyue Yue, Jing Wang, Shaoxuan Yu, Li Wang, Jianlong Wang
Oxygen evolution reaction (OER) has played a pivotal role in many energy conversion and storage technologies like water electrolysis, fuel cells, and metal-air batteries. However, the slow kinetics of OER limit the performance and commercialization of such devices. Herein, we report on NiFe LDH@Au hybrid nanoarrays on Ni foam for much enhanced OER. By hybridization of electronegative Au and NiFe LDH with intrinsic remarkable OER catalytic activity, this modular electrode could drive an overall ultrahigh-performance and robust OER in base with the demand of overpotentials of only 221, 235 and 270 mV to afford 50, 100 and 500 mA cm-2, respectively...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28530818/metal-foam-based-ultrafast-electronucleation-of-hydrates-at-low-voltages
#5
Arjang Shahriari, Palash Vadiraj Acharya, Katherine Carpenter, Vaibhav Bahadur
The induction time for the nucleation of hydrates can be significantly reduced by electronucleation, which consists of applying an electrical potential across the hydrate precursor solution. This study reveals that open-cell aluminum foam electrodes can reduce the electronucleation induction time by 150X, when compared to non-foam electrodes. Experiments with tetrahydrofuran hydrates show that aluminum foam electrodes trigger near-instantaneous nucleation (in only 10's of seconds) at low voltages. Furthermore, this study suggests that two distinct interfacial mechanisms influence electronucleation, namely electrolytic bubble generation, and the formation of metal ion complex-based coordination compounds...
May 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28527710/ccn3-regulates-macrophage-foam-cell-formation-and-atherosclerosis
#6
Hong Shi, Chao Zhang, Vinay Pasupuleti, Xingjian Hu, Domenick A Prosdocimo, Wenconghui Wu, Yulan Qing, Shitong Wu, Haneen Mohammad, Stanton L Gerson, Bernard Perbal, Philip A Klenotic, Nianguo Dong, Zhiyong Lin
Recent studies implicate the Cyr61, CTGF, Nov (CCN) matricellular signaling protein family as emerging players in vascular biology, with NOV (alias CCN3) as an important regulator of vascular homeostasis. Herein, we examined the role of CCN3 in the pathogenesis of atherosclerosis. In response to a 15-week high-fat diet feeding, CCN3-deficient mice on the atherosclerosis-prone Apoe(-/-) background developed increased aortic lipid-rich plaques compared to control Apoe(-/-) mice, a result that was observed in the absence of alterations in plasma lipid content...
June 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28527578/tr2-and-tr4-orphan-nuclear-receptors-an-overview
#7
Shin-Jen Lin, Dong-Rong Yang, Guosheng Yang, Chang-Yi Lin, Hong-Chiang Chang, Gonghui Li, Chawnshang Chang
Testicular nuclear receptors 2 and 4 (TR2, TR4), also known as NR2C1 and NR2C2, belong to the nuclear receptor superfamily and were first cloned in 1989 and 1994, respectively. Although classified as orphan receptors, several natural molecules, their metabolites, and synthetic compounds including polyunsaturated fatty acids (PUFAs), PUFA metabolites 13-hydroxyoctadecadienoic acid, 15-hydroxyeicosatetraenoic acid, and the antidiabetic drug thiazolidinediones can transactivate TR4. Importantly, many of these ligands/activators can also transactivate peroxisome proliferator-activated receptor gamma (PPARγ), also known as NR1C3 nuclear receptor...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28526345/facile-fabrication-of-3d-porous-hybrid-sphere-by-co-immobilization-of-multi-enzyme-directly-from-cell-lysates-as-an-efficient-and-recyclable-biocatalyst-for-asymmetric-reduction-with-coenzyme-regeneration-in-situ
#8
MinganYu, Duqiang Liu, Lili Sun, Jing Li, Qian Chen, Lijun Pan, Jingchuan Shang, Shurong Zhang, Wei Li
Ni(2+)-agarose bead-wrapped multi-enzyme/inorganic hybrid sphere composed of the immobilized enzymes as organic component and NaH2PO4 and NaCl as inorganic component was developed by co-immobilizing extracellular His-tagged 3-quinuclidinone reductases and glucose dehydrogenase without pre-purification. The resulting biocatalysts has 3D porous architectures as confirmed by SEM and FESEM, and it enabled the continuous biotransformation of 3-quinuclidone to (R)-3-quinuclidinol with cofactor regeneration in situ...
May 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28522412/athero-inflammatory-nanotherapeutics-ferulic-acid-based-poly-anhydride-ester-nanoparticles-attenuate-foam-cell-formation-by-regulating-macrophage-lipogenesis-and-reactive-oxygen-species-generation
#9
Rebecca A Chmielowski, Dalia S Abdelhamid, Jonathan J Faig, Latrisha K Petersen, Carol R Gardner, Kathryn E Uhrich, Laurie B Joseph, Prabhas V Moghe
Enhanced bioactive anti-oxidant formulations are critical for treatment of inflammatory diseases, such as atherosclerosis. A hallmark of early atherosclerosis is the uptake of oxidized low density lipoprotein (oxLDL) by macrophages, which results in foam cell and plaque formation in the arterial wall. The hypolipidemic, anti-inflammatory, and antioxidative properties of polyphenol compounds make them attractive targets for treatment of atherosclerosis. However, high concentrations of antioxidants can reverse their anti-atheroprotective properties and cause oxidative stress within the artery...
May 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28520604/in-vitro-evaluation-of-betafoam-a-new-polyurethane-foam-dressing
#10
Jae-A Jung, Seung-Kyu Han, Seong-Ho Jeong, Eun-Sang Dhong, Kang-Gyun Park, Woo-Kyung Kim
BACKGROUND: A new polyurethane foam dressing impregnated with 3% povidone-iodine (Betafoam; Genewell, Seoul, Korea) was recently developed based on the hypothesis that its physical properties, including improved moisture-retention capacity and antimicrobial activity, are at least as good as those achieved with the current foam dressings that contain silver, but also associated with reduced cost and cytotoxicity to host cells. The purpose of this in vitro study was to evaluate the efficacy of Betafoam by comparing its physical properties, antimicrobial activity, and cytotoxicity with those of 3 silver foam dressings (Allevyn-Ag [Smith & Nephew, Hull, United Kingdom]; Mepilex-Ag [Mölnlycke Health Care, Gothenburg, Sweden]; and PolyMem-Ag [Ferris MFG Corp, Burr Ridge, Illinois]) used worldwide...
June 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28515647/comparative-study-on-compositions-and-functional-properties-of-porcine-chicken-and-duck-blood
#11
Supaluk Sorapukdee, Supawadee Narunatsopanon
Hematological, chemical and functional characteristics of porcine, chicken and duck blood were evaluated. A porcine blood sample showed the most abundant red blood cell, hemoglobin concentration, packed cell volume and plasma protein content as well as its freeze-dried blood possessed the highest contents of protein, fat, Cu and Cr with the highest percentage of heme iron (p<0.05). Unlike porcine blood, chicken blood showed a well balance in some essential amino acids, specifically for a higher isoleucine content (p<0...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28506805/hdl-abnormalities-in-familial-hypercholesterolemia-focus-on-biological-functions
#12
REVIEW
Shiva Ganjali, Amir Abbas Momtazi, Maciej Banach, Petri T Kovanen, Evan A Stein, Amirhossein Sahebkar
Although a selective strong elevation in the plasma level of low-density lipoprotein (LDL) cholesterol is the hallmark of familial hypercholesterolemia (FH), also other plasma lipoprotein and lipid subspecies are changed in these patients. Several studies in FH patients have pointed to the qualitative abnormalities of high-density lipoprotein (HDL) particles, including their triglyceride and sphingomyelin enrichment, reduced capacity to promote cholesterol efflux from macrophages, impaired anti-inflammatory and anti-oxidant activities, and reduced plasma levels of miRs regulating HDL-dependent cholesterol efflux from macrophage foam cells, typical of atherosclerotic lesions...
May 12, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28501685/lipid-for-biodiesel-production-from-attached-growth-chlorella-vulgaris-biomass-cultivating-in-fluidized-bed-bioreactor-packed-with-polyurethane-foam-material
#13
Ainur-Assyakirin Mohd-Sahib, Jun-Wei Lim, Man-Kee Lam, Yoshimitsu Uemura, Mohamed Hasnain Isa, Chii-Dong Ho, Shamsul Rahman Mohamed Kutty, Chung-Yiin Wong, Siti-Suhailah Rosli
The potential to grow attached microalgae Chlorella vulgaris in fluidized bed bioreactor was materialized in this study, targeting to ease the harvesting process prior to biodiesel production. The proposed thermodynamic mechanism and physical property assessment of various support materials verified polyurethane to be suitable material favouring the spontaneous adhesion by microalgae cells. The 1-L bioreactor packed with only 2.4% (v/v) of 1.00-mL polyurethane foam cubes could achieve the highest attached growth microalgae biomass and lipid weights of 812±122 and 376±37mg, respectively, in comparison with other cube sizes...
May 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28500865/dihydromyricetin-ameliorates-atherosclerosis-in-ldl-receptor-deficient-mice
#14
Ting Ting Liu, Yi Zeng, Kun Tang, XueMeng Chen, Wei Zhang, Xiao Le Xu
BACKGROUND AND AIMS: Dihydromyricetin, the most abundant flavonoid in Ampelopsis grossedentata, exerts numerous pharmacological activities, including anti-inflammatory, antioxidant, hepatoprotective, and lipid regulatory activities; however, its protective effect against atherosclerosis remains poorly understood. The aim of the present study was to evaluate the effects of dihydromyricetin on high fat diet (HFD)-induced atherosclerosis using LDL receptor deficient (LDLr(-/-)) mice. METHODS: Blood samples were collected for determination of serum lipid profiles, oxidized LDL (ox-LDL) and pro-inflammatory cytokines...
May 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28500763/cross-talk-between-enzymes-matrix-metalloproteinsese-2-and-9-and-regulatory-t-cell-immunity-in-the-global-burden-of-atherosclerosis
#15
Andrica Lekic, Zdrinko Brekalo, Ante Kvesic, Miljenko Kovacevic, Zdenka Baricev-Novakovic, Ivana Sutic, Aleksandar Bulog, Ingrid Sutic, Valentino Pavisic, Ines Mrakovcic-Sutić
Changes in immune and inflammatory responses may play a crucial role in the development and progression of atherosclerosis, as an autoimmune, chronic and progressive inflammatory disease. Immunological activity and vascular inflammation during atherosclerosis can be modulated by autoimmune responses against self-antigens, according to changeable risk factors (cholesterol, oxidized low-density lipoprotein (ox-LDL) in the vascular wall, fatty acids, etc.) and accompanied by accumulation of leucocytes and proinflammatory cytokines, which stimulate the transcription of matrix-metalloproteinases (MMPs), whose concentration are increased in foam cell rich regions...
May 13, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28496130/an-aqueous-based-approach-for-fabrication-of-pvdf-mwcnt-porous-composites
#16
Hossein Rezvantalab, Nastaran Ghazi, Matthew J Ambrusch, Jeffrey Infante, Shahab Shojaei-Zadeh
In this paper, we demonstrate the fabrication of conductive porous polymers based on foaming of an aqueous dispersion of polymeric particles and multi-walled carbon nanotubes (CNT). By tuning the surface energy of the constituents, we direct their preferential adsorption at the air-liquid (bubble) interface or within the liquid film between the bubbles. Sintering this bi-constituent foam yields solid closed-cell porous structure which can be electrically conductive if CNT are able to form a conductive path...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28487312/complete-deletion-of-cd39-is-atheroprotective-in-apolipoprotein-e-deficient-mice
#17
Marco De Giorgi, Keiichi Enjyoji, Gordon Jiang, Eva Csizmadia, Shuji Mitsuhashi, Richard J Gumina, Ryszard T Smolenski, Simon C Robson
CD39 scavenges extracellular ATP and ADP, ultimately generating adenosine, a nucleoside, which has anti-inflammatory effects in the vasculature. We have evaluated the role of CD39 in the development of atherosclerosis in hyperlipidemic mice. ApoE KO (Cd39+/+/ApoE-/-) and Cd39/ApoE double knockout (Cd39-/-/ApoE-/-, DKO) mice were maintained on chow or Western diet for up to 20 weeks before evaluation of atherosclerotic lesions. We found that DKO mice exhibited significantly less atherosclerotic lesions than ApoE KO mice, irrespective of diet...
May 9, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28485501/mir-34a-targets-hdac1-regulated-h3k9-acetylation-on-lipid-accumulation-induced-by-homocysteine-in-foam-cells
#18
Qingguo Zhao, Shuqiang Li, Nan Li, Xiaoling Yang, Shengchao Ma, Anning Yang, Hui Zhang, Songhao Yang, Caiyan Mao, Lingbo Xu, Tingting Gao, Xiaoming Yang, Huiping Zhang, Yideng Jiang
Hyperhomocysteinemia (HHcy) promotes atherogenesis by modification of histone acetylation patterns and regulation of miRNA expression while the underlying molecular mechanisms are not well known. In this study, we investigated the effects of homocysteine (Hcy) on the expression of histone deacetylase 1 (HDAC1) and tested our hypothesis that Hcy-induced atherosclerosis is mediated by increased HDAC1 expression, which is regulated by miR-34a. The expression of HDAC1 increased and acetylation of histone H3 at lysine 9 (H3K9ac) decreased in the aorta of ApoE(-/-) mice fed with high methionine diet, whereas miR-34a expression was inhibited...
May 9, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28482474/characterization-of-synthetic-foam-structures-used-to-manufacture-artificial-vertebral-trabecular-bone
#19
David Fürst, Sascha Senck, Marianne Hollensteiner, Benjamin Esterer, Peter Augat, Felix Eckstein, Andreas Schrempf
Artificial materials reflecting the mechanical properties of human bone are essential for valid and reliable implant testing and design. They also are of great benefit for realistic simulation of surgical procedures. The objective of this study was therefore to characterize two groups of self-developed synthetic foam structures by static compressive testing and by microcomputed tomography. Two mineral fillers and varying amounts of a blowing agent were used to create different expansion behavior of the synthetic open-cell foams...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482260/increased-expression-of-tfpi-in-human-carotid-stenosis
#20
Benedicte Stavik, Sverre Holm, Sandra Espada, Nina Iversen, Bjørnar Sporsheim, Vigdis Bjerkeli, Tuva Børresdatter Dahl, Per Morten Sandset, Mona Skjelland, Terje Espevik, Grethe Skretting, Bente Halvorsen
INTRODUCTION: Tissue factor (TF) pathway inhibitor (TFPI) is the physiological inhibitor of TF induced blood coagulation and two isoforms exists, TFPIα and TFPIβ. In atherosclerotic plaques, TFPI may inhibit TF activity and thrombus formation, which is the main cause of ischemic stroke in carotid artery disease. We aimed to identify the isoforms of TFPI present in human carotid plaques and potential sources of TFPI. MATERIALS AND METHODS: Human atherosclerotic plaques from carotid endarterectomies were used for mRNA and immunohistochemistry analyses...
April 28, 2017: Thrombosis Research
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