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https://www.readbyqxmd.com/read/28322580/macrophage-kdm6b-controls-the-pro-fibrotic-transcriptome-signature-of-foam-cells
#1
Annette E Neele, Koen Hm Prange, Marten A Hoeksema, Saskia van der Velden, Tina Lucas, Stefanie Dimmeler, Esther Lutgens, Jan Van den Bossche, Menno Pj de Winther
AIM: In order to identify regulators of foam cells, we studied the H3K27 demethylase Kdm6b (also known as Jmjd3), a known regulator of macrophages, in controlling the transcriptional profile of foam cells. MATERIALS & METHODS: Foam cells from Kdm6b-deleted or Kdm6b wild-type mice were isolated and used for RNA-sequencing analysis. RESULTS: Pathway analysis revealed that pro-fibrotic pathways were strongly suppressed in Kdm6b-deleted foam cells...
March 21, 2017: Epigenomics
https://www.readbyqxmd.com/read/28321823/cardiovascular-disease-and-resuscitated-septic-shock-lead-to-the-downregulation-of-the-h2s-producing-enzyme-cystathionine-%C3%AE-lyase-in-the-porcine-coronary-artery
#2
Tamara Merz, Tatjana Stenzel, Benedikt Nußbaum, Martin Wepler, Csaba Szabo, Rui Wang, Peter Radermacher, Oscar McCook
BACKGROUND: Downregulation of the hydrogen sulfide (H2S)-producing enzymes cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and/or 3-mercaptopyruvate sulfurtransferase (3-MST) is associated with chronic cardiovascular pathologies. Nevertheless, equivocal data are available on both the expression and function of these enzymes in coronary arteries (CA). We recently reported that atherosclerotic pigs subjected to sepsis developed impaired cardiac function, which coincided with decreased myocardial CSE expression and increased nitrotyrosine formation...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28316603/dose-dependent-induction-of-an-idiotypic-cascade-by-anti-glycosaminoglycan-monoclonal-antibody-in-apoe-mice-association-with-atheroprotection
#3
Roger Sarduy, Victor Brito, Adriana Castillo, Yosdel Soto, Tania Griñán, Sylvie Marleau, Ana María Vázquez
Atherosclerosis, the underlying pathology of most cardiovascular diseases, is triggered by the retention of apolipoprotein B (apoB)-containing lipoproteins in the arterial wall through electrostatic interactions with glycosaminoglycan (GAG) side chains of proteoglycans. Previously, we reported the antiatherogenic properties of the chimeric monoclonal antibody (mAb) chP3R99-LALA, which binds sulfated GAGs, inhibits low-density lipoprotein (LDL)-chondroitin sulfate (CS) association, and abrogates LDL oxidation and foam cell formation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28315324/nucleolin-protects-macrophages-from-oxldl-induced-foam-cell-formation-through-up-regulating-abca1-expression
#4
Yuanbin Li, Bimei Jiang, Pengfei Liang, Zhongyi Tong, Meidong Liu, Qinglan Lv, Yanjuan Liu, Xuanyou Liu, Yuting Tang, Xianzhong Xiao
Our recent studies have indicated that nucleolin, as a multifunctional RNA-binding protein, exerts protective effects in the myocardial cells and endothelial cells under the condition of oxidative stress. However, the function of nucleolin and its potential mechanism in macrophage-derived foam cell formation remain largely unexplored. ApoE-/- mice were fed with a high-fat diet (HFD) for 10-24 weeks. Protein expression was measured by western blotting or immunofluorescence, and gene expression at the mRNA level was detected by qRT-PCR...
March 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28299190/apolipoprotein-b-containing-lipoproteins-and-atherosclerotic-cardiovascular-disease
#5
REVIEW
Michael D Shapiro, Sergio Fazio
Cholesterol-rich, apolipoprotein B (apoB)-containing lipoproteins are now widely accepted as the most important causal agents of atherosclerotic cardiovascular disease. Multiple unequivocal and orthogonal lines of evidence all converge on low-density lipoprotein and related particles as being the principal actors in the genesis of atherosclerosis. Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal factors that are required to initiate and maintain arterial degeneration...
2017: F1000Research
https://www.readbyqxmd.com/read/28297759/-expression-and-significance-of-integrin-%C3%AE-5%C3%AE-1-and-fibronectin-in-atherosclerotic-plaques-from-autopsy-specimens
#6
X Yu, Q Q Zhang, B Wang, L Sun
Objective: To investigate the expression of integrin α5β1 and fibronectin in the human aorta and coronary artery, and their effects in the development of atherosclerosis. Methods: One hundred and twenty autopsy aorta and coronary artery specimens were collected, and the expression of CD68, actin, integrin α5β1 and fibronectin was detected by immunohistochemical staining. Atherosclerotic plaques were located by CD68 and actin staining, and the degree of coronary artery stenosis was determined by elastic fiber staining and NIH Scion Image(60...
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28296196/sirt6-reduces-macrophage-foam-cell-formation-by-inducing-autophagy-and-cholesterol-efflux-under-ox-ldl-condition
#7
Jiangping He, Guangya Zhang, Qi Pang, Cong Yu, Jie Xiong, Jing Zhu, Fengling Chen
SIRT6 is a pivotal regulator of lipid metabolism. It is also closely connected to cardiovascular diseases, which are the main cause of death in diabetic patients. We observed a decrease in the expression of SIRT6 and key autophagy effectors (ATG5, LC3B, and LAMP1) in ox-LDL-induced foam cells, a special form of lipid-laden macrophages. In these cells, SIRT6 WT but not SIRT6 H133Y overexpression markedly reduced foam cell formation, as shown by Oil Red O staining, while inducing autophagy flux, as determined by both mRFP-GFP-LC3 labeling and transmission electron microscopy...
March 9, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28290811/-free-radical-processes-play-an-important-role-in-the-etiology-and-pathogenesis-of-atherosclerosis-and-diabetes
#8
V Z Lankin, A K Tikhaze
In this review, we present with exhaustive completeness the data of foreign studies and results of many years of own research, evidencing of the important role of free radical processes in the etiology and pathogenesis of atherosclerosis. The review contains the rationale for the concept that oxidative stress in atherosclerosis is even more developed during disorders of carbohydrate metabolism, contributing to the emergence of carbonyl stress in diabetes. We hypothesize that there exists a single common molecular mechanism of primary preatherogenic damages of vessel walls in atherosclerosis and diabetes, which enhances the formation of carbonyl-modified low-density lipoproteins to be accumulated in the foam cells...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28286758/role-of-vitamin-d-in-uremic-vascular-calcification
#9
REVIEW
Yi-Chou Hou, Wen-Chih Liu, Cai-Mei Zheng, Jing-Quan Zheng, Tzung-Hai Yen, Kuo-Cheng Lu
The risk of cardiovascular death is 10 times higher in patients with CKD (chronic kidney disease) than in those without CKD. Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. GFR decline, proteinuria, tubulointerstitial injury, and the therapeutic dose of active form vitamin D aggravate vitamin D deficiency and reduce its pleiotropic effect on the cardiovascular system...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28276237/unprecedented-development-of-ultrahigh-expansion-injection-molded-polypropylene-foams-by-introducing-hydrophobic-modified-cellulose-nanofibers
#10
Long Wang, Shota Ishihara, Yuta Hikima, Masahiro Ohshima, Takafumi Sekiguchi, Akihiro Sato, Hiroyuki Yano
Herein, an ultrahigh 18-fold expansion of isotactic polypropylene (iPP)/cellulose nanofiber (CNF) nanocomposite foams was achieved for the first time using a core-back foam injection molding technique. It was found that CNFs were well dispersed and aligned along the cell wall in the core-back direction. Interestingly, the formations of a hybrid shish-kebab of CNFs and classic shish-kebab of PP were simultaneously achieved in the PP/CNF composites. Finally, we proposed that the combination of local strong melt strength, probably resulting from the strong alignment of CNFs and subsequent formation of hybrid shish-kebab structures, and weak melt strength in the unreinforced PP melt might be the driving force for remarkably enhancing the PP foamability...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28274716/atractylenolide-i-restores-ho-1-expression-and-inhibits-ox-ldl-induced-vsmcs-proliferation-migration-and-inflammatory-responses-in-vitro
#11
Weifeng Li, Wenbing Zhi, Fang Liu, Zehong He, Xiuei Wang, Xiaofeng Niu
Pathogenesis of atherosclerosis is characterized by the proliferation and migration of vascular smooth muscle cells (VSMCs) and inflammatory lesions. The aim of this study is to elucidate the effect of atractylenolide I (AO-I) on smooth muscle cell inflammation, proliferation and migration induced by oxidized modified low density lipoprotein (Ox-LDL). Here, We found that atractylenolide I inhibited Ox-LDL-induced VSMCs proliferation and migration in a dose-dependent manner, and decreased the production of inflammatory cytokines and the expression of monocyte chemoattractant protein-1 (MCP-1) in VSMCs...
March 6, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28269987/a-simultaneously-antimicrobial-protein-repellent-and-cell-compatible-polyzwitterion-network
#12
Monika Kurowska, Alice Eickenscheidt, Diana Lorena Guevara-Solarte, Vania T Widyaya, Franziska Marx, Ali Al-Ahmad, Karen Lienkamp
A simultaneously antimicrobial, protein-repellent and cell-compatible surface-attached polymer network is reported, which reduced the growth of bacterial biofilms on surfaces through its multi-functionality. The coating was made from a poly(oxonorbornene)-based carboxybetaine (PZI), which was surface-attached and cross-linked in one step by simultaneous UV-activated CH insertion and thiol-ene reaction. The process was applicable to both laboratory surfaces like silicon, glass and gold, and real life surfaces like polyurethane foam wound dressings...
March 7, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28269209/three-dimensional-graphene-scaffold-for-cardiac-tissue-engineering-and-in-situ-electrical-recording
#13
S K Ameri, P K Singh, R D'Angelo, W Stoppel, L Black, S R Sonkusale
In this paper, we present a three-dimensional graphene foam made of few layers of CVD grown graphene as a scaffold for growing cardiac cells and recording their electrical activity. Our results show that graphene foam not only provides an excellent extra-cellular matrix (ECM) for the culture of such electrogenic cells but also enables recording of its extracellular electrical activity in-situ. Recording is possible due to graphene's excellent conductivity. In this paper, we present our results on the fabrication of the graphene scaffold and initial studies on the culture of cardiac cell lines such as HL-1 and recording of their real-time electrical activity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268696/a-simple-sensing-mechanism-for-wireless-passive-pressure-sensors
#14
John F Drazan, Michael T Wassick, Reena Dahle, Luke A Beardslee, Nathaniel C Cady, Eric H Ledet
We have developed a simple wireless pressure sensor that consists of only three electrically isolated components. Two conductive spirals are separated by a closed cell foam that deforms when exposed to changing pressures. This deformation changes the capacitance and thus the resonant frequency of the sensors. Prototype sensors were submerged and wirelessly interrogated while being exposed to physiologically relevant pressures from 10 to 130 mmHg. Sensors consistently exhibited a sensitivity of 4.35 kHz/mmHg which is sufficient for resolving physiologically relevant pressure changes in vivo...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262109/adult-xanthogranulomatous-disease-of-the-orbit-clinical-presentations-evaluation-and-management
#15
J M Ortiz Salvador, D Subiabre Ferrer, A Pérez Ferriols
Adult xanthogranulomatous disease of the orbit refers to a heterogeneous group of clinical syndromes with differing degrees of systemic involvement and distinct prognoses. The different syndromes all present clinically with progressively enlarging, yellowish lesions of the orbit. Histologically, the lesions are characterized by an inflammatory infiltrate of foam cells and Touton-type multinucleated giant cells. The xanthomatized histiocytes are CD68(+), S100(-), and CD1a(-). There are 4 clinical forms of xanthogranulomatous disease of the orbit: adult xanthogranulomatous disease of the orbit, adult onset asthma and periocular xanthogranuloma, necrobiotic xanthogranuloma, and Erdheim-Chester disease...
March 2, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28259785/protection-mechanisms-of-the-carapace-of-a-box-turtle
#16
Bingbing An, H Daniel Wagner
In this study we explore the materials design principles of the carapace of a Terrapene Carolina box turtle, which possesses a sandwich-like structure consisting of a foam-like interior layer (FIL) enclosed by two dense exterior layers (DEL). A constitutive scheme accounting for the large deformation, plastic yielding and post-yield strain hardening caused by densification of the cells in the foam is developed to model the mechanical properties of the FIL, and a large deformation elastic-plastic model for the DEL is proposed...
February 24, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28259375/sr-bi-a-multifunctional-receptor-in-cholesterol-homeostasis-and-atherosclerosis
#17
REVIEW
MacRae F Linton, Huan Tao, Edward F Linton, Patricia G Yancey
The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile. Through the selective uptake of HDL lipids, hepatic SR-BI modulates HDL composition and preserves HDL's atheroprotective functions of mediating cholesterol efflux and minimizing inflammation and oxidation. Macrophage and endothelial cell SR-BI inhibits the development of atherosclerosis by mediating cholesterol trafficking to minimize atherosclerotic lesion foam cell formation...
March 1, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28258256/decreased-adiponectin-mediated-signaling-through-the-adipor2-pathway-is-associated-with-carotid-plaque-instability
#18
Karina Gasbarrino, Huaien Zheng, Anouar Hafiane, John P Veinot, Chi Lai, Stella S Daskalopoulou
BACKGROUND AND PURPOSE: Adiponectin, the most abundantly secreted anti-inflammatory adipokine, protects against all stages of atherosclerotic plaque formation by acting on its receptors, AdipoR1 (adiponectin receptor 1) and AdipoR2 (adiponectin receptor 2). Through binding of AdipoR1, adiponectin leads to the activation of the AMPK (adenosine monophosphate-activated protein kinase) pathway, whereas stimulation of PPAR-α (peroxisome proliferator-activated receptor-α) is attributed to the binding of AdipoR2...
March 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28257760/induction-of-mir133a-expression-by-il-19-targets-ldlrap1-and-reduces-oxldl-uptake-in-vsmc
#19
Khatuna Gabunia, Allison B Herman, Mitali Ray, Sheri E Kelemen, Ross N England, Raul DeLa Cadena, William J Foster, Katherine J Elliott, Satoru Eguchi, Michael V Autieri
The transformation of vascular smooth muscle cells [VSMC] into foam cells leading to increased plaque size and decreased stability is a key, yet understudied step in atherogenesis. We reported that Interleukin-19 (IL-19), a novel, anti-inflammatory cytokine, attenuates atherosclerosis by anti-inflammatory effects on VSMC. In this work we report that IL-19 induces expression of miR133a, a muscle-specific miRNA, in VSMC. Although previously unreported, we report that miR133a can target and reduce mRNA abundance, mRNA stability, and protein expression of Low Density Lipoprotein Receptor Adaptor Protein 1, (LDLRAP1), an adaptor protein which functions to internalize the LDL receptor...
February 28, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28253220/fat-mass-and-obesity-associated-protein-attenuates-lipid-accumulation-in-macrophage-foam-cells-and-alleviates-atherosclerosis-in-apolipoprotein-e-deficient-mice
#20
Chunfen Mo, Ming Yang, Xiaojuan Han, Junhong Li, Guangping Gao, Haoran Tai, Ning Huang, Hengyi Xiao
OBJECTIVE: Genome-wide association studies have linked variants of fat mass and obesity-associated protein (FTO) to obesity. However, the molecular function of FTO remains unclear. In this study, we sought to investigate the potential effects of FTO in modulating cholesterol deposition in macrophage foam cells, as well as whether FTO exerts antiatherosclerotic properties in apolipoprotein E-deficient mice. METHOD AND RESULTS: We transfected RAW264.7 cells with plasmids encoding a wild-type or mutant FTO gene (I367F)...
April 2017: Journal of Hypertension
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