Lisanne A E M van Houtum, William F C Baaré, Christian F Beckmann, Josefina Castro-Fornieles, Charlotte A M Cecil, Juliane Dittrich, Bjørn H Ebdrup, Jörg M Fegert, Alexandra Havdahl, Manon H J Hillegers, Raffael Kalisch, Steven A Kushner, Isabelle M Mansuy, Signe Mežinska, Carmen Moreno, Ryan L Muetzel, Alexander Neumann, Merete Nordentoft, Jean-Baptiste Pingault, Martin Preisig, Andrea Raballo, John Saunders, Emma Sprooten, Gisela Sugranyes, Henning Tiemeier, Geeske M van Woerden, Caroline L Vandeleur, Neeltje E M van Haren
Over 50% of children with a parent with severe mental illness will develop mental illness by early adulthood. However, intergenerational transmission of risk for mental illness in one's children is insufficiently considered in clinical practice, nor is it sufficiently utilised into diagnostics and care for children of ill parents. This leads to delays in diagnosing young offspring and missed opportunities for protective actions and resilience strengthening. Prior twin, family, and adoption studies suggest that the aetiology of mental illness is governed by a complex interplay of genetic and environmental factors, potentially mediated by changes in epigenetic programming and brain development...
April 13, 2024: European Child & Adolescent Psychiatry