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osteonecrosis of the femoral head

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https://www.readbyqxmd.com/read/29775946/il-9-exhibits-elevated-expression-in-osteonecrosis-of-femoral-head-patients-and-promotes-cartilage-degradation-through-activation-of-jak-stat-signaling-in-vitro
#1
Wei Geng, Wen Zhang, Jinzhu Ma
Osteonecrosis of the femoral head (ONFH) often causes severe symptoms in young people and limits the mobility of the hip joint. Interleukin-9 (IL-9) is a multi-functional inflammatory factor that participates in lumbar disk herniation and arthritis and has been reported in many studies. However, the correlation between IL-9 and ONFH is unclear. The present study aimed to determine the role of IL-9 in the pathogenetic mechanism of osteonecrosis. To assess IL-9 expression in ONFH and femoral neck fracture patients, cartilage tissue was examined through western blot analysis and immunohistochemistry...
May 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29771853/corr-insights%C3%A2-which-classification-system-is-most-useful-for-classifying-osteonecrosis-of-the-femoral-head
#2
Michael J Grecula
No abstract text is available yet for this article.
June 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29761221/interest-of-short-implants-in-hip-arthroplasty-for-osteonecrosis-of-the-femoral-head-comparative-study-uncemented-short-vs-cemented-conventional-femoral-stems
#3
Mehdi Miladi, Benoît Villain, Nasser Mebtouche, Thierry Bégué, Jean-Charles Aurégan
PURPOSES: Osteonecrosis of the femoral head (ONFH) is a dramatic condition resulting in joint destruction in the late stages. Total hip arthroplasty allows function recovery with satisfactory implant survival. Recently, the use of uncemented short stems has been suggested to improve the conservation of bone stock. METHODS: We performed a retrospective study on 16 hip arthroplasties-11 patients-implanted for ONFH between 2008 and 2017. We aimed to compare the outcomes of the two types of arthroplasty-"uncemented short" vs "cemented conventional" femoral stem-in terms of pain (visual analogue scale), function (Harris Hip Score), and survival (radiography)...
May 15, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29758548/stromal-cell-derived-factor-sdf-1-alpha-overexpression-promotes-bone-regeneration-by-osteogenesis-and-angiogenesis-in-osteonecrosis-of-the-femoral-head
#4
Fan Yang, Feng Xue, Junjie Guan, Zeng Zhang, Jimin Yin, Qingling Kang
BACKGROUND/AIMS: Osteonecrosis of the femoral head (ONFH) is a devastating orthopedic disease. Previous studies suggested that stromal-cell-derived factor (SDF)-1 was involved in osteogenesis and angiogenesis. However, whether SDF-1 potentiates the angiogenesis and osteogenesis of bone marrow-derived stromal stem cells (BMSCs) in ONFH is not clear. METHODS: BMSCs were transfected with green fluorescent protein (GFP) or the fusion gene encoding GFP and SDF-1α, and transgenic efficacy was monitored by immunofluorescence...
May 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29755607/risk-factors-for-the-development-of-nerve-palsy-following-primary-total-hip-arthroplasty
#5
Shunsuke Kawano, Motoki Sonohata, Masaru Kitajima, Masaaki Mawatari
Background: Nerve palsy following total hip arthroplasty (THA) is a complication that worsens the functional prognosis. The present study analyzed the risk factors of nerve palsy following THA. Methods: The subjects of this study included 6,123 cases in which primary THA was performed under spinal anesthesia with cementless implants used in the posterolateral approach. Results: Fourteen cases (0.22%) developed nerve palsy following THA, all of which involved palsy of the entire peroneal nerve region...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29754187/nationwide-multicenter-follow-up-cohort-study-of-hip-arthroplasties-performed-for-osteonecrosis-of-the-femoral-head
#6
Seneki Kobayashi, Toshikazu Kubo, Yukihide Iwamoto, Wakaba Fukushima, Nobuhiko Sugano
PURPOSE: To identify modifiable factors related to post-operative dislocation and reoperation in patients with osteonecrosis of the femoral head (ONFH) in a large cohort. METHODS: We studied 4995 hip arthroplasties: total hip arthroplasty (THA) was performed in 79% of patients; bipolar hemiarthroplasty (BP), 17%; total resurfacing arthroplasty (tRS), 3%; and hemi-resurfacing arthroplasty (hRS), 1%. A new type of BP (accounting for 49% of BPs) comprised a femoral component with a polished or smooth, small-diameter (approximately 10 mm) neck with a round or oval axial cut surface and no sharp corners...
May 12, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29750162/screening-of-serum-protein-markers-for-avascular-osteonecrosis-of-femoral-head-differentially-expressed-after-treatment-with-yuanshi-shengmai-chenggu-tablets
#7
Peng Deng, Jianchun Zeng, Jie Li, Wenjun Feng, Jinlun Chen, Yirong Zeng
Avascular necrosis of the femoral head (ANFH) is an a frequently occurring orthopaedic disease with high morbidity. Traditional Chinese Medicine (TCM) Yuanshi Shengmai Chenggu Tablet is a valid prescription for treating steroid-induced femoral head necrosis. However, there are rare investigations about the serum protein marker expression after the acting of drugs on hormone and TCM. In the present study, we aimed to systematically discover and validate the serum biomarkers expression difference in patients with steroid-induced avascular necrosis of femoral head (SANFH) after taking Yuanshi Shengmai Chenggu Tablets (SANFH-TCM), so as to reveal the action mechanism of TCM from the molecular level by using isobaric tags for relative and absolute quantification (iTRAQ) with multiple reaction monitoring quantification...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29744647/cell-therapy-versus-simultaneous-contralateral-decompression-in-symptomatic-corticosteroid-osteonecrosis-a-thirty-year-follow-up-prospective-randomized-study-of-one-hundred-and-twenty-five-adult-patients
#8
Philippe Hernigou, Arnaud Dubory, Yasuhiro Homma, Isaac Guissou, Charles Henri Flouzat Lachaniette, Nathalie Chevallier, Hélène Rouard
PURPOSE: Symptomatic osteonecrosis related to corticosteroids has a high risk of progression to collapse in absence of treatment. The purposes of this study were to evaluate the results of autologous bone marrow grafting of the symptomatic hip in adult patients with osteonecrosis and to compare the results with core decompression alone in the contralateral symptomatic hip. MATERIALS AND METHODS: A total of 125 consecutive patients (78 males and 47 females) with bilateral osteonecrosis (ON) and who had both hips symptomatic and at the same stage on each side (stage I or II) were included in this study from 1988 to 1998...
May 9, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29729342/safflower-carthamus-tinctorius-l-polysaccharide-attenuates-cellular-apoptosis-in-steroid-induced-avascular-necrosis-of-femoral-head-by-targeting-caspase-3-dependent-signaling-pathway
#9
Daping Cui, Dewei Zhao, Benjie Wang, Baoyi Liu, Lei Yang, Hui Xie, Zihua Wang, Liangliang Cheng, Xing Qiu, Zhijie Ma, Mingyang Yu, Di Wu, Hao Long
The present study aimed to investigate the effects of a purified polysaccharide (SPS) from the safflower in a cellular model of steroid-associated necrosis of the femoral head (SANFH), which was established in primary murine osteoblasts suffering dexamethasone pretreatment. After treatment with SPS (25, 50 and 100 μg/ml), the degree of necrosis induced by dexamethasone was significantly reduced in osteoblasts as evidenced by an increase of cell viability and a decrease of apoptosis in osteoblasts. Furthermore, pretreatment with SPS (25, 50 and 100 μg/ml) significantly attenuated the activation of caspase-3 and cleavage of PARP relative to the model control cells...
May 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29728832/the-depth-of-the-low-intensity-band-on-the-t1-weighted-mr-image-is-useful-for-distinguishing-subchondral-insufficiency-fracture-from-osteonecrosis-of-the-collapsed-femoral-head
#10
Satoshi Ikemura, Taro Mawatari, Gen Matsui, Takahiro Iguchi, Hiroaki Mitsuyasu
PURPOSE: To verify the hypothesis that depth of the low-intensity band on T1-weighted MR image is useful for distinguishing subchondral insufficiency fracture (SIF) from osteonecrosis of the collapsed femoral head (ON). PATIENTS AND METHODS: We reviewed 35 consecutive hips in 35 patients with radiological evidence of subchondral collapse of the femoral head and available MR images and histology between May 2013 and January 2016. Both clinical and radiological appearances were investigated...
May 4, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29728733/what-is-the-rate-of-patients-undergoing-a-total-hip-arthroplasty-after-core-decompression-and-insertion-of-a-tantalum-rod-in-osteonecrosis-of-the-femoral-head-a-systematic-review
#11
Jean-Charles Aurégan, Benoît Villain, Thierry Bégué
PURPOSE: Core decompression (CD) may be effective when performed during the early stages of osteonecrosis of the femoral head (ONFH). Tantalum may be added as a rod that would allow putting some mechanical constraints on the femoral head. We aimed to estimate the rate of total hip arthroplasty after CD and insertion of a tantalum rod during early stages of OFNH. METHODS: We searched systematically Medline via PubMed and the Cochrane Library. Our primary endpoint was the rate of patients undergoing a total hip arthroplasty after CD and insertion of a tantalum rod...
May 4, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29725783/stem-cell-therapy-for-osteonecrosis-of-the-femoral-head-current-trends-and-comprehensive-review
#12
REVIEW
Lei Zhao, Alan David Kaye, Aaron J Kaye, Alaa Abd-Elsayed
PURPOSE OF REVIEW: Osteonecrosis of the femoral head (ONFH) is a common and frequently occurring disease. It is caused by interruption of blood supply with different etiologies. ONFH leads to degeneration and necrosis of the subchondral bone of the femoral head and eventually collapse of the femoral head. ONFH has a high disability rate, seriously affecting the quality of living of patients, and often involves middle-aged and younger people. RECENT FINDINGS: In recent years, the technology and understanding of stem cells and regenerative medicine have been developing rapidly...
May 3, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29705871/mid-term-results-of-concentrated-autologous-bone-marrow-aspirate-transplantation-for-corticosteroid-associated-osteonecrosis-of-the-femoral-head-in-systemic-lupus-erythematosus
#13
Yohei Tomaru, Tomokazu Yoshioka, Hisashi Sugaya, Yukiyo Shimizu, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Masashi Yamazaki, Hajime Mishima
PURPOSE: We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head (ONFH). This study aimed to evaluate the effects of CABMAT as a hip-preserving surgical approach, preventing conversion to total hip arthroplasty (THA) and femoral head collapse in patients with systemic lupus erythematosus (SLE). METHODS: Since 2003, 52 SLE patients (8 male, 44 female, 92 hips, mean age 35...
April 28, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29705870/animal-models-of-steroid-induced-osteonecrosis-of-the-femoral-head-a-comprehensive-research-review-up-to-2018
#14
REVIEW
Jianzhong Xu, Hanpu Gong, Shitao Lu, Matthey J Deasey, Quanjun Cui
Osteonecrosis of the femoral head (ONFH) is a significant cause of both pain and disability that often affects young adults during what ought to be their most productive age. Two broad categories of ONFH exist: traumatic and non-traumatic. Traumatic ONFH results from acute mechanical disruption of the femoral head's blood supply. Many factors that increase the risk of non-traumatic osteonecrosis have been identified. Steroid-induced osteonecrosis of the femoral head (SONFH) is the most common form of non-traumatic ONFH...
April 28, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29704023/radiological-analysis-of-cystic-lesion-in-osteonecrosis-of-the-femoral-head
#15
Fuqiang Gao, Jun Han, Zike He, Zirong Li
PURPOSE: Cystic lesions are a common complication in osteonecrosis of the femoral head (ONFH). This study will discuss the cause of cystic lesion formation and the feature of cystic lesion distribution in ONFH. According to the feature of cystic lesion in ONFH, we will discuss the possible mechanisms of cystic lesions and their  influence on collapse of the femoral head. MATERIALS AND METHODS: We retrospectively gathered 102 ONFH patients (168 hips) from November in 2015 to August in 2016 on China-Japan Friendship Hospital...
April 27, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29700584/microrna-mediated-interacting-circuits-predict-hypoxia-and-inhibited-osteogenesis-of-stem-cells-and-dysregulated-angiogenesis-are-involved-in-osteonecrosis-of-the-femoral-head
#16
Gour-Shenq Kao, Yuan-Kun Tu, Pei-Hsun Sung, Feng-Sheng Wang, Yu-Der Lu, Chen-Ta Wu, Rio L C Lin, Hon-Kan Yip, Mel S Lee
PURPOSE: MicroRNAs (miRNAs) are associated with various pathologic conditions and can serve as diagnostic or therapeutic biomarkers. This study tried to identify the differentially expressed miRNAs to predict the possible pathomechanisms involved in osteonecrosis of the femoral head (ONFH). METHODS: We compared the peripheral blood miRNAs in 46 patients with ONFH and 85 healthy controls by microarray and droplet digital polymerase chain reaction (ddPCR). Putative interacted networks between the differentially responded miRNAs were analyzed by web-based bioinformatics prediction tools...
April 26, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29700582/delay-of-total-hip-arthroplasty-to-advanced-stage-worsens-post-operative-hip-motion-in-patients-with-femoral-head-osteonecrosis
#17
Woo-Lam Jo, Young-Kyun Lee, Yong-Chan Ha, Tae-Young Kim, Kyung-Hoi Koo
PURPOSE: Osteonecrosis of the femoral head (ONFH) is commonly detected in young patients and most surgeons tend to delay total hip arthroplasty (THA) until the end stage of the disease. We hypothesised that post-operative range of motion (ROM) of the hip as well as baseline ROM at the time of surgery decreases with the disease progression. The purpose of this study was to determine whether patients, who were operated at an advanced stage, have pre- and post-operative hip ROM similar to ROM of patients, who were operated at earlier stages...
April 26, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29698301/is-there-an-association-between-borderline-to-mild-dysplasia-and-hip-osteoarthritis-analysis-of-ct-osteoabsorptiometry
#18
Tohru Irie, Daisuke Takahashi, Tsuyoshi Asano, Ryuta Arai, Muhammad Alaa Terkawi, Yoichi M Ito, Norimasa Iwasaki
BACKGROUND: The definitive treatment of borderline-to-mild dysplasia remains controversial. A more comprehensive understanding of the etiology of osteoarthritis (OA) and clarification of any possible association between borderline-to-mild dysplasia and the pathogenesis of OA are essential. QUESTIONS/PURPOSES: (1) Does the distribution of acetabular subchondral bone density increase according to dysplasia severity? (2) Is there an association between borderline-to-mild dysplasia and OA pathogenesis? METHODS: We evaluated bilateral hips of patients with developmental dysplasia of the hip who underwent eccentric rotational acetabular osteotomy (ERAO) for inclusion in the dysplasia group and contralateral hips of patients with unilateral idiopathic osteonecrosis of the femoral head (ONFH) who underwent curved intertrochanteric varus osteotomy (CVO) for the control group...
April 23, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29695195/serum-levels-of-carotenoids-in-patients-with-osteonecrosis-of-the-femoral-head-are-lower-than-in-healthy-community-living-people
#19
Toshiaki Okura, Taisuke Seki, Koji Suzuki, Naoki Ishiguro, Yukiharu Hasegawa
PURPOSE: Oxidative stress is closely associated with the pathogenesis of nontraumatic osteonecrosis of the femoral head (ONFH). This study aimed to determine whether the serum levels of antioxidant nutrients were decreased in patients with ONFH. METHODS: We analyzed the serum levels of antioxidant nutrients in 39 patients with ONFH (ONFH group) and 78 age- and gender-matched healthy people (control group) who voluntarily participated in the Yakumo study, which is a comprehensive health examination program...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29691613/lesion-size-measurement-in-femoral-head-necrosis
#20
Marvin E Steinberg, Seong C Oh, Viviane Khoury, Jayaram K Udupa, David R Steinberg
BACKGROUND: Management of patients with early stages of osteonecrosis of the femoral head remains controversial. Uniform use of an effective method of evaluation and classification, including both stage and lesion size, would allow for comparison and would significantly improve treatment of patients. There is no consensus on how best to determine lesion size. The purpose of this study was to evaluate and compare accuracy and ease of use of different techniques for determining the size of femoral head lesions...
April 25, 2018: International Orthopaedics
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