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osteonecrosis of the femoral head

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https://www.readbyqxmd.com/read/28819826/the-outcome-of-the-partial-resurfacing-arthroplasty-of-the-hip-shows-high-numbers-of-failures-and-conversion-to-total-arthroplasty
#1
Thilo Floerkemeier, Stefan Budde, Nils Wirries, Gabriela von Lewinski, Henning Windhagen, Marco Ezechieli
PURPOSE: Local cartilage and bony defects, which are too large for joint preserving cartilage treatment are difficult to treat. The implantation of a mini-resurfacing implant (Hemicap®, 2med, Hamburg, Germany) may be a possible alternative treatment for these patients. This partial replacement fills the defect and restores a smooth and continuous articular surface. The aim of this study was to determine short- to midterm results of the treatment of local cartilage defects of the femoral head using the Hemicap®...
August 17, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28817157/extent-and-morbidity-of-lateralization-of-a-trochanteric-fixation-nail-blade
#2
Phillip A Sandifer, Robert M Hulick, Matthew L Graves, Clay A Spitler, George V Russell, Josie M Hydrick, LaRita C Jones, Patrick F Bergin
This study examined the incidence and risk factors associated with lateral helical blade migration and trochanteric pain with the trochanteric fixation nail. A retrospective review was performed of 141 cases of pertrochanteric femur fracture treated with a trochanteric fixation nail at a level I trauma center over a period of 42 months. Exclusion criteria included follow-up of less than 60 days, preexisting osteonecrosis of the femoral head, and prophylactic trochanteric fixation nail treatment. Patient demographics, operative findings, and radiographic findings were recorded...
August 17, 2017: Orthopedics
https://www.readbyqxmd.com/read/28811813/osteonecrosis-in-the-both-femoral-heads-in-a-patient-with-neuro-behcet-s-disease
#3
Asuman Orhan Varoglu, Asude Aksoy
Neuro-Behçet's disease (NBD) is a rare clinical entity that frequently presents neuro-psychiatric symptoms, and mesodiencephalic and pontobulbar lesions. There is only one published report about osteonecrosis in NBD. We report a patient whose first presentation was neurological NBD with presenting bilateral femoral heads osteonecrosis. A 36-year-old male was hospitalized with gait disorder, diplopia and speech disorder. The past medical history of the patient was unremarkable. The MR image showed mesencephalic lesion with oedemaas a hyperintense area...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28805950/management-of-osteonecrosis-of-the-femoral-head-with-pedicled-iliac-bone-flap-transfer-a-multicenter-study-of-2190-patients
#4
Dewei Zhao, Hui Xie, Yongqing Xu, Yisheng Wang, Aixi Yu, Youwen Liu, Aimin Wang, Wei He, Xiuli Wang, Zirong Li, Wei Sun, Simiao Tian, Benjie Wang, Baoyi Liu
BACKGROUND: Osteonecrosis of the femoral head (ONFH) often affects young active adults and leads to destruction of the hip joint and disabling arthritis. Several procedures have been developed to arrest the progress of osteonecrosis and postpone the procedure of total hip replacement especially in young patients. The aim of this multicenter study was to analyze the results of the use of the vascularized iliac bone flap transfer for management of ONFH. METHODS: From January 1985 to December 2012, a total of 2190 patients (2690 hips) with the mean age of 43...
August 14, 2017: Microsurgery
https://www.readbyqxmd.com/read/28797104/increased-microrna-93-5p-inhibits-osteogenic-differentiation-by-targeting-bone-morphogenetic-protein-2
#5
Ying Zhang, Qiu-Shi Wei, Wei-Bin Ding, Lei-Lei Zhang, Hui-Chao Wang, Ying-Jie Zhu, Wei He, Yu-Na Chai, You-Wen Liu
BACKGROUND AND PURPOSE: Trauma-induced osteonecrosis of the femoral head (TIONFH) is a major complication of femoral neck fractures. Degeneration and necrosis of subchondral bone can cause collapse, which results in hip joint dysfunction in patients. The destruction of bone metabolism homeostasis is an important factor for osteonecrosis. MicroRNAs (miRNAs) have an important role in regulating osteogenic differentiation, but the mechanisms underlying abnormal bone metabolism of TIONFH are poorly understood...
2017: PloS One
https://www.readbyqxmd.com/read/28782831/customized-degradable-functionally-graded-scaffold-for-potential-treatment-of-early-stage-osteonecrosis-of-the-femoral-head
#6
Toshiyuki Kawai, Yaser Shanjani, Saba Fazeli, Anthony W Behn, Yaichiro Okuzu, Stuart B Goodman, Yunzhi P Yang
Osteonecrosis of the femoral head (ONFH) is a debilitating disease that results in progressive collapse of the femoral head and subsequent degenerative arthritis. Few treatments provide both sufficient mechanical support and biological cues for regeneration of bone and vascularity when the femoral head is still round and therefore salvageable. We designed and 3D printed a functionally-graded scaffold (FGS) made of polycaprolactone (PCL) and β-tricalcium phosphate (β-TCP) with spatially controlled porosity, degradation and mechanical strength properties to reconstruct necrotic bone tissue in the femoral head...
August 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28782700/effects-of-intertrochanteric-osteotomy-plane-and-pre-operative-femoral-anteversion-on-the-post-operative-morphology-of-the-proximal-femur-in-transtrochanteric-anterior-rotational-osteotomy-3d-ct-based-simulation-study
#7
Kazuhiko Sonoda, Goro Motomura, Satoshi Ikemura, Yusuke Kubo, Takuaki Yamamoto, Yasuharu Nakashima
BACKGROUND: Transtrochanteric anterior rotational osteotomy (ARO) is joint-preserving surgery for patients with osteonecrosis of the femoral head (ONFH).During ARO, femoral neck-shaft varus angulation by changing intertrochanteric osteotomy plane is often designed to obtain a sufficient post-operative intact ratio. However, the effect of intertrochanteric osteotomy plane on post-operative femoral anteversion has not been well examined.Therefore we performed a simulation study of ARO to determinehow intertrochanteric osteotomy plane and pre-operative femoral anteversionaffect both femoral neck-shaft varus angle and post-operative femoral anteversion...
August 3, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28777523/transient-osteoporosis-of-the-hip-treated-with-hyperbaric-oxygen-therapy-a-case-series
#8
Kazuyoshi Yagishita, Tetsuya Jinno, Daisuke Koga, Tsuyoshi Kato, Mitsuhiro Enomoto, Tsuyoshi Kato, Takeshi Muneta, Atsushi Okawa
INTRODUCTION: Transient osteoporosis of the hip (TOH) is a self-limiting disorder characterized by bone marrow edema at the femoral head and neck. Patients report pain as moderate or severe at onset; pain gradually subsides at about six months (range four to 12 months). Differential diagnosis of the early stages of osteonecrosis of the femoral head (ONFH) is sometimes difficult. Because hyperbaric oxygen (HBO₂) therapy is effective for reduction of edema in soft tissue injury and early stages of ONFH, we hypothesized that HBO₂ could be effective in TOH for accelerated recovery...
November 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28774681/sildenafil-improves-blood-perfusion-in-steroid-induced-avascular-necrosis-of-femoral-head-in-rabbits-via-a-protein-kinase-g-dependent-mechanism
#9
Qichun Song, Jianlong Ni, Hongyuan Jiang, Zhibin Shi
OBJECTIVE: The aim of the study were to evaluate the effect of sildenafil against avascular necrosis of femoral head (ANFH) in a rabbit model, and to study the role of protein kinase G (PKG) pathway and vascular endothelial growth factor (VEGF) in ANFH. METHODS: Three weeks after inducing ANFH with methylprednisolone injection, 45 female adult New Zealand white rabbits were divided into three groups and treated as follows: group SI received daily intraperitoneal sildenafil with a dose of 10 mg/kg per day; group SD received daily sildenafil identically to group SI plus auricular vein injection DT3 (a specific PKG inhibitor); group NS received only normal saline...
July 31, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28770971/apolipoprotein-a1-and-neuronal-nitric-oxide-synthase-gene-polymorphisms-and-hormone-related-osteonecrosis-of-the-femoral-head
#10
L Chen, P Wei, K Jiang, X-X Xia
OBJECTIVE: This study was designed to investigate the influence of several polymorphisms in neuronal NOS genes and apolipoprotein AI on the hormone-related osteonecrosis of the femoral head (ONFH) risk. PATIENTS AND METHODS: Peripheral blood mononuclear cell (PBMCs) samples extracted from hormone-related ONFH patients and controls were used to amplify fragments of the apolipoprotein A1 and neuronal NOS exon 7 and intron 4 using specific PCR primers. The products were analyzed by DNA sequencing and mapped to find the genotype distributions...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28760127/does-platelet-rich-plasma-have-a-favorable-effect-in-the-early-stages-of-steroid-associated-femoral-head-osteonecrosis-in-a-rabbit-model
#11
Mustafa Karakaplan, Deniz Gülabi, Haldun Topgül, Nurzat Elmalı
OBJECTIVES: This study aims to investigate the effect of platelet-rich plasma (PRP) on femoral head osteonecrosis and compare it with bone marrow injection and core decompression. MATERIALS AND METHODS: A total of 30 healthy, adult, male New Zealand white rabbits (mean weight 2.25±0.15 kg; range 2.0 to 2.5 kg) were used in the study. To create experimental osteonecrosis in all rabbits, 40 mg/kg methylprednisolone acetate was applied intramuscularly. Rabbits were randomly allocated into three groups with 10 rabbits in each: drilling group, PRP group, and bone marrow group...
August 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/28754159/the-role-of-electrical-stimulation-in-the-management-of-avascular-necrosis-of-the-femoral-head-in-adults-a-systematic-review
#12
Talal Al-Jabri, Jessica Yan Qi Tan, Gabriel Yihan Tong, Ravikiran Shenoy, Babar Kayani, Timothy Parratt, Tahir Khan
BACKGROUND: Avascular necrosis of the femoral head causes significant morbidity and occurs in up to 20,000 people per year. A variety of nonoperative and operative measures have been trialled however a definitive treatment algorithm is yet to be established. Young adults in many cases have undergone multiple surgical procedures in their lifetime with increasing risks of complications. Less invasive techniques may help reduce the number of operations required and positively influence the natural history of the disease process...
July 28, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28732374/the-protective-effect-of-pft%C3%AE-on-alcohol-induced-osteonecrosis-of-the-femoral-head
#13
Yi-Xuan Chen, Dao-Yu Zhu, Jun-Hui Yin, Wen-Jing Yin, Yue-Lei Zhang, Hao Ding, Xiao-Wei Yu, Jiong Mei, You-Shui Gao, Chang-Qing Zhang
Epidemiologic studies have shown alcohol plays a pivotal role in the development of osteonecrosis of the femoral head (ONFH). The aim of this study was to explore the underlying mechanism of alcohol-induced ONFH and the protective effect of pifithrin-α (PFTα). In vitro, we found ethanol treatment significantly activated p53, suppressed Wnt/β-catenin signaling and inhibited osteogenic-related proteins. Furthermore, by separating the cytoplasmic and nuclear proteins, we found ethanol inhibited osteogenesis by impairing the accumulation of β-catenin in both the cytoplasm and nucleus in human bone mesenchymal stem cells (hBMSCs), which resulted from activating glycogen synthase kinase-3β (GSK-3β)...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28716026/short-stem-total-hip-arthroplasty-for-osteonecrosis-of-the-femoral-head-in-patients-60%C3%A2-years-or-younger-a-3-to-10-year-follow-up-study
#14
Antonio Capone, Fabrizio Bienati, Stefania Torchia, Daniele Podda, Giuseppe Marongiu
BACKGROUND: In young patients with osteonecrosis of the femoral head (ONFH), short-stem total hip arthroplasty (THA) could allow a potential advantage in preserving metaphyseal bone-stock, when revision surgery might become necessary. However, only a few studies have evaluated the outcome of short-stem THAs in ONFH. We reviewed the prospectively collected data of a cementless partial neck-retaining short-stem with ceramic-on-ceramic bearings in ONFH patients. METHODS: Thirty patients (37 hips) younger than 60 years (mean age at surgery, 51...
July 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28698612/eif2%C3%AE-signaling-regulates-ischemic-osteonecrosis-through-endoplasmic-reticulum-stress
#15
Daquan Liu, Yunlong Zhang, Xinle Li, Jie Li, Shuang Yang, Xiaoxue Xing, Guanwei Fan, Hiroki Yokota, Ping Zhang
Osteonecrosis of the femoral head (ONFH) primarily results from ischemia/hypoxia to the femoral head, and one of the cellular manifestations is the endoplasmic reticulum (ER) stress. To understand possible linkage of ischemic osteonecrosis to the ER stress, a surgery-induced animal model was employed and salubrinal was administered to evaluate the role of ER stress. Salubrinal is a synthetic chemical that inhibits de-phosphorylation of eIF2α, and it can suppress cell death from the ER stress at a proper dose...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698139/11%C3%AE-hydroxysteroid-dehydrogenases-2-decreases-the-apoptosis-of-mc3t3-mlo-y4-cells-induced-by-glucocorticoids
#16
Hao Zhang, Fuling Zhou, Zhenyu Pan, Xiangpeng Bu, Yaoqing Wang, Fan Chen
The aim of the present study was to confirm the role of 11β-hydroxysteroid dehydrogenases type 2(11β-HSD-2) in steroid induced osteonecrosis of the femoral head(SANFH). We cultured mouse bone-like cells (MLO-Y4) and mouse osteoblast-like cells (MC3T3-E1). After overexpressed 11β-HSD-2 successfully, we induced cell apoptosis by dexamethasone (DXM). The level of cell apoptosis, the expression of Bcl-2 in MLO-Y4 cells and the expression of Fas and caspase8 in MC3T3-E1 cells were detected. Then, we constructed 11β-HSD-2 siRNA plasmid and represented it on MLO-Y4/MC3T3-E1 Cells, to down-regulate the 11β-HSD-2 expression...
September 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28689862/histological-fibrosis-may-predict-the-failure-of-core-decompression-in-the-treatment-of-osteonecrosis-of-the-femoral-head
#17
Francesco Sadile, Alessio Bernasconi, Flavio Carbone, François Lintz, Gelsomina Mansueto
PURPOSE: Osteonecrosis of femoral head (ONFH) is histopathologically characterized by necrotic areas associated with reactive fibrosis, trabecular bone remodeling and thickening zones. Our double goal was to evaluate if: 1) main ONFH risk factors were related to specific histological specimen patterns 2) different histological patterns were related to the final outcome after a core decompression (CD) procedure. METHODS: This observational longitudinal cohort study respected the STROBE statement...
July 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28685377/alcohol-intake-and-the-risk-of-osteonecrosis-of-the-femoral-head-in-japanese-populations-a-dose-response-meta-analysis-of-case-control-studies
#18
Byung-Ho Yoon, Tae-Young Kim, In-Soo Shin, Hee Young Lee, Yun Jong Lee, Kyung-Hoi Koo
Studies examining the association between alcohol intake and the risk of osteonecrosis of the femoral head (ONFH) have inconsistent results. The purpose of this study was to examine and summarize the evidence regarding the association between alcohol intake and ONFH based on results from case-control studies. This analysis included five case-control studies reporting data from 1251 individuals. Alcohol intake habits (never, former, or current), average drinking consumption (g/week), and cumulative drinking consumption (drink-years) were extracted...
July 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28683795/hip-preserving-surgery-with-concentrated-autologous-bone-marrow-aspirate-transplantation-for-the-treatment-of-asymptomatic-osteonecrosis-of-the-femoral-head-retrospective-review-of-clinical-and-radiological-outcomes-at-6%C3%A2-years-postoperatively
#19
Yohei Tomaru, Tomokazu Yoshioka, Hisashi Sugaya, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Masashi Yamazaki, Hajime Mishima
BACKGROUND: We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head (ONFH). The present study aimed to evaluate the effects of CABMAT as a hip preserving surgical approach, preventing femoral head collapse in asymptomatic ONFH. METHODS: In total, 222 patients (341 hips) with ONFH were treated with CABMAT between April 2003 and March 2013...
July 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28682898/heterotopic-ossification-related-to-the-use-of-recombinant-human-bmp-2-in-osteonecrosis-of-femoral-head
#20
Lijun Shi, Wei Sun, Fuqiang Gao, Liming Cheng, Zirong Li
Despite the wide use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in bone defect, its application in treating osteonecrosis of femoral head (ONFH) is yet to be elucidated. The heterotopic ossification (HO) after rhBMP-2 usage in some orthopedic surgeries has been reported previously; however, only a few studies describe this complication in the treatment of ONFH.The present study investigated whether the rhBMP-2 application would increase the risk of HO formation in selected ONFH patients with nonvascularized bone grafting surgery and enhance the surgical results of nonvascularized bone grafting as compared to patients who did not receive intraoperative rhBMP-2...
July 2017: Medicine (Baltimore)
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