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osteonecrosis of the femoral head

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https://www.readbyqxmd.com/read/28529456/ethyl-acetate-fraction-of-huogu-formula-inhibits-adipogenic-differentiation-of-bone-marrow-stromal-cells-via-the-bmp-and-wnt-signaling-pathways
#1
Xiangying Kong, Xiaomin Li, Cun Zhang, Liuluan Zhu, Chunfang Liu, Qingxia Qin, Cuiling Liu, Qianqian Wang, Jia Zhu, Xuan Wu, Hongye Wan, Weiheng Chen, Na Lin
Elevated adipogenesis of bone marrow stromal cells (BMSCs) is closely associated with non-traumatic osteonecrosis of femoral head (ONFH). Our previous studies have shown that Huogu (HG) formula was effective both in clinic experience and experimental ONFH. How HG impacts the differentiation of BMSCs and what is the underlying molecular mechanism remain largely unknown. Our results showed that ethyl acetate extract of HG (HGE) significantly decreased the adipocyte differentiation as determined by oil red staining, while slightly increased the ALP activity...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28529111/the-results-of-total-hip-arthroplasty-after-sugioka-transtrochanteric-anterior-rotational-osteotomy-for-osteonecrosis
#2
Takeshi Utsunomiya, Goro Motomura, Satoshi Ikemura, Satoshi Hamai, Jun-Ichi Fukushi, Yasuharu Nakashima
BACKGROUND: Since Sugioka transtrochanteric anterior rotational osteotomy (ARO) for osteonecrosis of the femoral head (ONFH) changes the morphology of the proximal femur, total hip arthroplasty (THA) after previous ARO is considered a technically demanding procedure. The purpose of this study was to compare the clinicoradiologic outcomes of THA after ARO with those of THA without any antecedent surgery for ONFH. METHODS: Twenty-four hips in 20 patients who underwent cementless THA after ARO (postosteotomy group) were retrospectively reviewed and compared with patients who underwent cementless THA without any antecedent surgery for ONFH during the same period (primary group)...
April 27, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28514285/association-of-abcb1-c3435t-polymorphism-with-the-susceptibility-to-osteonecrosis-of-the-femoral-head-a-meta-analysis
#3
Yu Zhang, Hui Xie, Dewei Zhao, Benjie Wang, Lei Yang, Qingyu Meng
BACKGROUND AND OBJECTIVE: The exploration for the etiology of osteonecrosis of the femoral head (ONFH) has got some promising findings, but the morbidity of ONFH is still not under control. The C3435T polymorphism of ATP-binding cassette subfamily B member 1 (ABCB1) gene has been reported to possess significant influence on ONFH onset, but relevant outcomes remain conflicting rather than conclusive. Therefore, a meta-analysis was useful to pool these results together for a more reliable conclusion...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28498798/differential-expression-of-mir-195-5p-in-collapse-of-steroid-induced-osteonecrosis-of-the-femoral-head
#4
Pengfei Li, Pei Zhai, Zengjie Ye, Peng Deng, Yueguang Fan, Yirong Zeng, Zhihui Pang, Jianchun Zeng, Jie Li, Wenjun Feng
BACKGROUND: Femoral head collapse is a key reference point for determining a treatment regimen of femoral head osteonecrosis. However, there are no effective preventive measures and the efficacy of hip-preserving surgery is unsatisfactory due to the unclear mechanism of collapse. This study aimed to identify and validate miRNAs differentially expressed in collapse and non-collapse areas of the osteonecrotic femoral head, and to predict the target genes and pathways of these miRNAs. RESULTS: Nine samples passed the quality control test...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28497454/efficacy-of-core-decompression-for-treatment-of-canine-femoral-head-osteonecrosis-induced-by-arterial-ischaemia-and-venous-congestion
#5
Yupeng Liu, Dewei Zhao, Weiming Wang, Yao Zhang, Benjie Wang, Zhigang Li
METHODS: 40 healthy mixed-breed dogs were randomly divided into 2 groups, arterial ischaemia (AI) and venous congestion (VC), each containing 20 dogs. The dogs underwent a procedure where the deep femoral artery or deep femoral vein was ligated randomly on the left or right side to establish the femoral head osteonecrosis model. 13 dogs from each group, AI and VC, were randomly selected for subsequent study. 3 dogs were randomly chosen from each group to receive core decompression (CD) every 2 weeks for a total of 4 sessions...
May 10, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28474152/free-vascularized-fibular-grafting-improves-vascularity-compared-with-core-decompression-in-femoral-head-osteonecrosis-a-randomized-clinical-trial
#6
Lu Cao, Changan Guo, Jifei Chen, Zenggan Chen, Zuoqin Yan
BACKGROUND: Management of osteonecrosis of the femoral head remains challenging. Core decompression and free vascularized fibular grafting are commonly used surgical procedures for treatment of osteonecrosis of the femoral head. Few studies, however, have compared these two procedures in a randomized controlled study, in terms of improved vascularity of the femoral head, progression of disease, or hip scores. QUESTION/PURPOSES: (1) What is the effect of core decompression and fibular grafting on vascularity of the femoral head as measured by single-photon emission CT (SPECT)/CT? (2) Does one of these two methods lead to greater progression of Association Research Circulation Osseous (ARCO) stage as determined by serial MRI? (3) What is the relationship between the change in vascularity of the femoral head and hip function as measured by the Harris hip score (HHS) and progression to THA as an endpoint? METHODS: A randomized controlled trial was performed between June 2010 and October 2012 at Zhongshan Hospital, Fudan University...
May 4, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28459353/role-of-coagulopathy-in-glucocorticoid-induced-osteonecrosis-of-the-femoral-head
#7
Qiankun Zhang, Jin L V, Lie Jin
The two major theories of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH) are apoptosis and ischaemia. The traditional theory implicates ischaemia as the main aetiological factor because the final common pathway of ONFH is interruption of blood supply to the bone. The most common causes of interruption of blood supply include fat embolism and coagulation disorders. GCs can directly or indirectly lead to coagulation disorders, producing a hypercoagulable state, followed by poor blood flow, ischaemia, and eventually ONFH...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28458706/an-epidemiological-study-of-etiology-and-clinical-characteristics-in-patients-with-nontraumatic-osteonecrosis-of-the-femoral-head
#8
Feng Liu, Wei Wang, Lei Yang, Benjie Wang, Jianchuan Wang, Weifang Chai, Dewei Zhao
BACKGROUND: Osteonecrosis of the femoral head (ONFH) is a common disease with high disability rate. However, a few studies investigate the etiology and clinical characteristics of nontraumatic ONFH patients in China. Therefore, we conducted this cross-sectional study. MATERIALS AND METHODS: Totally, information of 7268 nontraumatic ONFH patients treated between August 2005 and August 2015 was extracted from the medical records. The extracted information included the age, gender, diagnostic criteria, cause of nontraumatic ONFH, types of steroid use, and types of alcohol...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28445942/mmp-3-and-mmp-8-single-nucleotide-polymorphisms-are-related-to-alcohol-induced-osteonecrosis-of-the-femoral-head-in-chinese-males
#9
Junyu Chen, Wanlin Liu, Yuju Cao, Xiyang Zhang, Yongchang Guo, Yong Zhu, Jian Li, Jieli Du, Tianbo Jin, Guoqiang Wang, Jianzhong Wang
Our study investigated the association between MMP-3 and MMP-8 single-nucleotide polymorphisms (SNPs) and alcohol-induced osteonecrosis of the femoral head (ONFH) in 695 Chinese males (299 cases and 396 control subjects). The minor allele of MMP-3 rs650108 was associated with a 0.78-fold decrease in alcohol-induced ONFH risk in the allelic model (95% CI = 0.63-0.97, P = 0.026). In the genetic model adjusted for age, rs650108 was associated with decreased risk of alcohol-induced ONFH in the dominant model (OR = 0...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427427/association-between-the-ossific-nucleus-and-osteonecrosis-in-treating-developmental-dysplasia-of-the-hip-updated-meta-analysis
#10
Rafal Niziol, Michael Elvey, Evangelia Protopapa, Andreas Roposch
BACKGROUND: A meta-analysis concluded that there was no effect of the femoral head ossification and the incidence of osteonecrosis in the treatment of developmental dysplasia of the hip (DDH), unless only osteonecrosis grades II-IV were considered. The meta-analysis, limited due to the small number of studies available at that time, identified a need for an update as further research emerges. We observed a trend in recent years towards delaying treatment of DDH in the absence of an ossified nucleus...
April 20, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28423488/mmp8-polymorphism-is-associated-with-susceptibility-to-osteonecrosis-of-the-femoral-head-in-a-chinese-han-population
#11
Feimeng An, Jieli Du, Yuju Cao, Jianping Shi, Yongchang Guo, Tianbo Jin, Jian Li, Junyu Chen, Ping Li, Mei Dong, Guoqiang Wang, Jianzhong Wang
Osteonecrosis of the femoral head (ONFH) is an orthopedic refractory disease that adversely affects quality of life. Matrix metalloproteinase-8 (MMP-8) produced by the bone marrow has been implicated in the degradation of collagen during bone development. We assessed whether MMP8 polymorphisms are associated with ONFH. In a case-control study, using χ2 tests and genetic model analyses, we genotyped 5 MMP8 single-nucleotide polymorphisms (SNPs) in 585 ONFH patients and 507 healthy control subjects in a Chinese Han population...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422866/the-use-of-anticoagulants-for-prevention-and-treatment-of-osteonecrosis-of-the-femoral-head-a-systematic-review
#12
REVIEW
Peipei Guo, Fuqiang Gao, Yanhua Wang, Zhenkun Zhang, Wei Sun, Baoguo Jiang, Bailiang Wang, Zirong Li
BACKGROUND: Osteonecrosis of the femoral head (ONFH) is a progressive disease, which mainly affects young adults and often necessitates total hip arthroplasty (THA), so early interventions are critical to successfully protect hip joint from THA. In this review, our purpose was to determine the effects of anticoagulants for preventing and treating the primary and secondary ONFH, respectively, before the collapse stage or before the pathology of necrosis. METHODS: We searched PubMed, Embase, Web of Science databases for relevant studies...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422712/combination-analysis-of-nos3-abcb1-and-il23r-polymorphisms-with-alcohol-induced-osteonecrosis-of-the-femoral-head-risk-in-chinese-males
#13
Yuan Wang, Xuejun Yang, Jianping Shi, Yan Zhao, Linlin Pan, Jinqiu Zhou, Guoqiang Wang, Jianzhong Wang
BACKGROUND: Common variants of multiple genes played a crucial role in osteonecrosis of the femoral head (ONFH) onset which was proved by many previous reports. We hypothesized that polymorphisms in NOS3, ABCB1 and IL23R were related to individual differences in alcohol sensitivity and the development of alcohol-induced ONFH. METHODS: In this case-control study, we evaluated 8 SNPs in three genes in the Chinese Han population including 355 male cases and 355 healthy male controls...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415829/association-between-alcohol-induced-osteonecrosis-of-femoral-head-and-risk-variants-of-mmps-in-han-population-based-on-a-case-control-study
#14
Jianzhong Wang, Xugang Shi, Hua Yang, Jieli Du, Yongri Ouyang, Hong Wang, Tianbo Jin, Chao Chen
The study aimed to evaluate the association between MMP gene superfamily and alcohol-induced osteonecrosis of femoral head (alcohol-induced ONFH) risk given its high prevalence, poor therapeutic effect, and serious clinical prognosis. 308 subjects (mean age, 49.47 years; males, 64.0%) who participated in our control group and 300 alcohol-induced ONFH patients (mean age, 43.29 years; males, 99.7%) formed the case group was enrolled to estimate by statistical analysis. We selected 23 single nucleotide polymorphisms (SNPs) from MMPs, and performed the chi-squared test, Fisher's exact test, t-test and genetic model analyses...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415692/novel-akt-activator-sc-79-is-a-potential-treatment-for-alcohol-induced-osteonecrosis-of-the-femoral-head
#15
Yi-Xuan Chen, Shi-Cong Tao, Zheng-Liang Xu, Wen-Jing Yin, Yue-Lei Zhang, Jun-Hui Yin, You-Shui Gao, Chang-Qing Zhang
Alcohol is a leading risk factor for osteonecrosis of the femoral head (ONFH). We explored the molecular mechanisms underlying alcohol-induced ONFH and investigated the protective effect of the novel Akt activator SC-79 against this disease. We found that ethanol inhibited expression of the osteogenic genes RUNX2 and OCN, downregulated osteogenic differentiation, impaired the recruitment of Akt to the plasma membrane, and suppressed Akt phosphorylation at Ser473, thereby inhibiting the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415025/unusual-combination-of-femoral-head-dislocation-associated-acetabular-fracture-with-multipart-femoral-fractures-case-report
#16
Erdal Uzun, Ali Eray Günay, İbrahim Karaman, Abdülhamit Mısır, Turan Bilge Kızkapan, Mustafa Özçamdallı
INTRODUCTION: Traumatic hip dislocation associated with femur intertrocanteric fracture is a rare and severe injury and it frequently occurs following a high energy trauma, Associated acetabular fractures with this injury are even more rare and potentially cause devastating consequences including avascular necrosis of the femoral head and subsequent early secondary osteoarthritis of the hip joint. PRESENTATION OF CASE: In this case report, we present a 20year old polytraumatized patient with traumatic hip dislocation associated with ipsilateral acetabulum fracture and simultaneous fractures of the ipsilateral femur...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28400676/erratum-core-decompression-or-quadratus-femoris-muscle-pedicle-bone-grafting-for-nontraumatic-osteonecrosis-of-the-femoral-head-a-randomized-control-study
#17
(no author information available yet)
[This corrects the article on p. 629 in vol. 50, PMID: 27904218.].
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28392136/analysis-of-cell-therapies-used-in-clinical-trials-for-the-treatment-of-osteonecrosis-of-the-femoral-head-a-systematic-review-of-the-literature
#18
REVIEW
Nicolas S Piuzzi, Jorge Chahla, Hao Jiandong, Morad Chughtai, Robert F LaPrade, Michael A Mont, George F Muschler, Cecilia Pascual-Garrido
BACKGROUND: Osteonecrosis of the femoral head (ONFH) is associated with regional loss of cells within bone, often resulting in pain and mechanical collapse. Our purpose was to analyze the cell-therapies used in clinical trials for the treatment of ONFH with regard to (1) cell-sources, (2) collection techniques, (3) cell-processing, (4) qualitative and quantitative characterizations, and (5) delivery methods. METHODS: A systematic review of the current literature on the use of cell therapies for the treatment of ONFH was performed...
March 15, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28386565/a-10-year-follow-up-of-two-incision-and-modified-watson-jones-total-hip-arthroplasty-in-patients-with-osteonecrosis-of-the-femoral-head
#19
Shih-Jie Lin, Tsan-Wen Huang, Po-Chun Lin, Feng-Chih Kuo, Kuo-Ti Peng, Kuo-Chin Huang, Mel S Lee
Long-term data and information indicating whether minimally invasive surgery (MIS) approaches are safe and effective with total hip arthroplasty (THA) are lacking. Between 2004 and 2006, 75 patients with alcohol-related osteonecrosis of the femoral head (ONFH) who underwent 75 THAs with the two-incision approach were studied. The medical records, radiographic parameters, and functional outcomes were collected prospectively. All data were compared with those for matched patients who underwent a modified Watson-Jones (WJ) approach...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28371498/chinese-guideline-for-the-diagnosis-and-treatment-of-osteonecrosis-of-the-femoral-head-in-adults
#20
(no author information available yet)
The treatment of adult osteonecrosis of the femoral head (ONFH), with 8.12 million patients in China, remains a challenge to surgeons. To standardize and improve the efficacy of the treatment of ONFH, Chinese specialists updated the experts' suggestions in March 2015, and an experts' consensus was given to provide a current basis for the diagnosis, treatment and evaluation of ONFH. The current guideline provides recommendations for ONFH with respect to epidemiology, etiology, diagnostic criteria, differential diagnosis, staging, treatment, as well as rehabilitation...
February 2017: Orthopaedic Surgery
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