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osteonecrosis of the femoral head

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https://www.readbyqxmd.com/read/28634093/total-hip-arthroplasty-after-transtrochanteric-rotational-osteotomy-for-osteonecrosis-of-the-femoral-head-a-mean-10-year-follow-up
#1
Yusuke Osawa, Taisuke Seki, Daigo Morita, Yasuhiko Takegami, Toshiaki Okura, Naoki Ishiguro
BACKGROUND: The objective of the present study was to investigate clinical, quality of life, and radiographic outcomes of patients who underwent total hip arthroplasty (THA) after transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head (ONFH). METHODS: We performed a case-control study. The participants were 29 patients (34 hips) who underwent THA after TRO (TRO group). These patients had a mean age at surgery of 51.6 years (range, 30-72 years) and underwent postoperative follow-up for a mean period of 10...
May 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28623889/surgical-accuracy-function-and-quality-of-life-of-simultaneous-versus-staged-bilateral-total-hip-arthroplasty-in-patients-with-osteonecrosis-of-the-femoral-head
#2
Seung-Chan Kim, Young-Wook Lim, Woo-Lam Jo, Dong-Chul Park, Jin-Woo Lee, Won-Woo Kang, Yong-Sik Kim
BACKGROUND: The optimal surgical option for patients requiring bilateral hip replacement remains controversial. The purpose of this study was to compare surgical accuracy; functional outcome and health-related quality of life; and prosthetic-related complications and revision surgery of a simultaneous bilateral total hip arthroplasty (THA) with those of a staged bilateral THA with an interval between procedures <12 months. METHODS: A total of 123 unselected consecutive patients (mean age, 43...
June 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28606016/research-in-the-precaution-of-recombinant-human-erythropoietin-to-steroid-induced-osteonecrosis-of-the-rat-femoral-head
#3
Lu-Yong Jiang, Xiao Yu, Qing-Jiang Pang
Objective To elucidate the effects of recombinant human erythropoietin (rHuEPO) on steroid-induced osteonecrosis of the femoral head in rats. Methods Twenty-four adult Wistar rats were randomly divided into three groups of eight rats each. The rats in the positive control group were injected with dexamethasone at 1 mg/kg twice a week for 5 weeks. The rats in the negative control group were injected with sodium chloride alone. The rats in the experimental group were injected with dexamethasone at 1 mg/kg twice a week for 5 weeks and rHuEPO (500 u/d/kg) daily for 5 weeks...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28583419/modified-dynamic-hip-screw-loaded-with-autologous-bone-graft-for-treating-pauwels-type-3-vertical-femoral-neck-fractures
#4
Deqing Luo, Weitao Zou, Yijiao He, Hang Xian, Lei Wang, Jiazuo Shen, Kejian Lian, Dasheng Lin
INTRODUCTION: Management of Pauwels type-3 vertical femoral neck fractures has been a challenging clinical problem as they experience high shear forces and thus a greater risk of treatment failure. There is no apparent consensus on the optimal implant type for these injuries. We developed a modified dynamic hip screw (DHS), which was designed to a cage in the lag screw, loaded with autologous bone graft for the treatment of Pauwels type-3 vertical femoral neck fractures. METHODS: Between February 2010 and January 2012, 17 consecutive patients with Pauwels type-3 vertical femoral neck fractures were treated with the modified DHS loaded with autologous bone graft...
May 26, 2017: Injury
https://www.readbyqxmd.com/read/28578459/late-versus-early-reduction-in-traumatic-hip-dislocations-a-meta-analysis
#5
Ghalib Ahmed, Salman Shiraz, Muhammad Riaz, Talal Ibrahim
AIMS: Traumatic hip dislocations are considered orthopaedic emergencies that are treated with urgent reduction to decrease the rate of osteonecrosis of the femoral head. The aim of our study was to systematically review the literature that compares late (>6 h from the time of injury) to early (<6 h from the time of injury) reduction in all traumatic hip dislocations. MATERIALS AND METHODS: We searched five databases from 1951 to 2016 for studies that evaluated timing of reduction and osteonecrosis of the femoral head in all traumatic hip dislocations...
June 3, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28574127/influence-of-cigarette-smoking-on-osteonecrosis-of-the-femoral-head-onfh-a-systematic-review-and-meta-analysis
#6
Zhenxing Wen, Zan Lin, Wenlong Yan, Jian Zhang
BACKGROUND: Current studies demonstrate controversy regarding the relationship between cigarette smoking and osteonecrosis of the femoral head (ONFH). METHODS: We conducted a meta-analysis to evaluate the association between smoking and ONFH. Relevant articles published before September 2016 were identified by a systematic search of EMBASE and MEDLINE via Ovid. Summary odds ratios (OR) were calculated using random effects models, and study quality was assessed using a modified Newcastle-Ottawa scale...
May 29, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28574118/wear-of-xlpe-liner-against-zirconium-heads-in-cementless-total-hip-arthroplasty-for-patients-under-40-years-of-age
#7
Motoki Sonohata, Masaru Kitajima, Shunsuke Kawano, Masaaki Mawatari
INTRODUCTION: Total hip arthroplasty (THA) in the young is challenging. The purpose of this study was to retrospectively determine the clinical, radiographic, and polyethylene wear rate of relatively young patients. METHODS: We evaluated the outcome of consecutive patients receiving primary THA who were under 40 years of age with a minimum 10-year follow-up. Indications for THA in these patients were osteoarthritis due to developmental dysplasia of the hip joint (9 hips), osteonecrosis of the femoral head (7 hips), juvenile idiopathic arthritis (2 hips), and osteoarthritis due to Perthes disease (1 hip)...
May 27, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28567217/comparison-of-surgical-parameters-and-results-between-curved-varus-osteotomy-and-rotational-osteotomy-for-osteonecrosis-of-the-femoral-head
#8
Young-Kyun Lee, Chan Ho Park, Yong-Chan Ha, Do-Yeon Kim, Sung-Hwa Lyu, Kyung-Hoi Koo
BACKGROUND: Various osteotomies have been introduced to treat osteonecrosis of the femoral head. The purpose of this study was to compare surgical parameters, postoperative limb length discrepancy, and minimum 5-year clinical and radiological results between transtrochanteric curved varus osteotomy (TCVO) and transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head. METHODS: From 2004 to 2009, 103 consecutive TROs (97 patients) followed by 72 consecutive TCVOs (64 patients) were performed for the treatment of osteonecrosis of the femoral head...
June 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28555365/long-term-results-of-rotational-acetabular-osteotomy-for-osteonecrosis-with-collapse-of-the-femoral-head-in-young-patients
#9
Tomonori Baba, Masahiko Nozawa, Yasuhiro Homma, Hironori Ochi, Yu Ozaki, Taiji Watari, Mikio Matsumoto, Kazuo Kaneko
PURPOSE: The surgical treatment of osteonecrosis with collapse of the femoral head is still controversial. The purpose of this study was to investigate the clinical outcome of rotational acetabular osteotomy by Ninomiya and Tagawa for osteonecrosis of the femoral head in young patients. PATIENTS AND METHODS: Rotational acetabular osteotomy was performed in 202 consecutive patients between 1995 and 2003. Among them, rotational acetabular osteotomy with osteonecrosis of the femoral head was performed in 31 patients (42 hips)...
May 29, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28543623/regulatory-effect-of-microrna-34a-on-osteogenesis-and-angiogenesis-in-glucocorticoid-induced-osteonecrosis-of-the-femoral-head
#10
Xiaolong Zha, Bolin Sun, Rufan Zhang, Chen Li, Zuoqin Yan, Jifei Chen
BACKGROUND AND AIMS: Glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) is a common and devastating orthopedic disease, and its underlying mechanism remains unclear. The aim of this study was to determine the role of microRNA-34a (mir-34a) in GIOFH. METHODS: C57 mouse mesenchymal stem cells (mMSCs) and human umbilical vein endothelial cells (HUVECs) were cultured with dexamethasone (Dex). A total of 48 adult rats were treated with glucocorticoids, and after the onset of GIOFH, each femoral head was removed...
May 20, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28543357/associations-of-tnf-%C3%AE-238-a-g-and-il-10-1082-g-a-genetic-polymorphisms-with-the-risk-of-nonfh-in-the-chinese-population
#11
Biao-Fang Wei, Zhi Feng, Wei Wei, Xiao Chen
The study aims to explore the roles of common polymorphisms of TNF-α (-238 A/G and -308 A/G) and IL-10 (-819 T/C and -1082 G/A) genes in the risk of non-traumatic osteonecrosis of the femoral head (NONFH). One-hundred and forty-seven NONFH patients and 135 healthy individuals were selected as the case and control groups. qRT-PCR and Western blotting techniques detected mRNA as well as protein expressions of TNF-α and IL-10 of each genotype in both the case and control groups. The GA genotype and the A allele of TNF-α -238 A/G were higher in the case group than in the control group...
May 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28540628/effect-of-collapse-on-the-deformity-of-the-femoral-head-neck-junction-in-osteonecrosis-of-the-femoral-head
#12
Yusuke Kubo, Goro Motomura, Satoshi Ikemura, Kazuhiko Sonoda, Takuaki Yamamoto, Yasuharu Nakashima
INTRODUCTION: The purpose of this study was to morphologically assess the effect of collapse on the deformity of the femoral head-neck junction in patients with nontraumatic osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS: From January 2005 through March 2016, magnetic resonance (MR) imaging including the oblique view was repeatedly performed before and after collapse in 24 hips of patients with ONFH (16 men, 8 women; mean age 43 years; range 23-68 years), that were the subjects of this study...
May 24, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28537800/advanced-mri-techniques-for-the-hip-joint-focus-on-the-postoperative-hip
#13
Jennifer L Berkowitz, Hollis G Potter
OBJECTIVE: Imaging the hip joint with optimized MRI protocol parameters provides the radiologist with the ability to reliably diagnose complex hip abnormalities. The institution of appropriate metal artifact reduction techniques and dedicated sequences can enhance visualization of the periprosthetic bone and soft tissues and allow improved detection of the more frequently encountered total hip arthroplasty-related conditions, such as mechanical loosening, polyethylene wear, and adverse local tissue reactions...
May 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28529456/ethyl-acetate-fraction-of-huogu-formula-inhibits-adipogenic-differentiation-of-bone-marrow-stromal-cells-via-the-bmp-and-wnt-signaling-pathways
#14
Xiangying Kong, Xiaomin Li, Cun Zhang, Liuluan Zhu, Chunfang Liu, Qingxia Qin, Cuiling Liu, Qianqian Wang, Jia Zhu, Xuan Wu, Hongye Wan, Weiheng Chen, Na Lin
Elevated adipogenesis of bone marrow stromal cells (BMSCs) is closely associated with non-traumatic osteonecrosis of femoral head (ONFH). Our previous studies have shown that Huogu (HG) formula was effective both in clinic experience and experimental ONFH. How HG impacts the differentiation of BMSCs and what is the underlying molecular mechanism remain largely unknown. Our results showed that ethyl acetate extract of HG (HGE) significantly decreased the adipocyte differentiation as determined by oil red staining, while slightly increased the ALP activity...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28529111/the-results-of-total-hip-arthroplasty-after-sugioka-transtrochanteric-anterior-rotational-osteotomy-for-osteonecrosis
#15
Takeshi Utsunomiya, Goro Motomura, Satoshi Ikemura, Satoshi Hamai, Jun-Ichi Fukushi, Yasuharu Nakashima
BACKGROUND: Since Sugioka transtrochanteric anterior rotational osteotomy (ARO) for osteonecrosis of the femoral head (ONFH) changes the morphology of the proximal femur, total hip arthroplasty (THA) after previous ARO is considered a technically demanding procedure. The purpose of this study was to compare the clinicoradiologic outcomes of THA after ARO with those of THA without any antecedent surgery for ONFH. METHODS: Twenty-four hips in 20 patients who underwent cementless THA after ARO (postosteotomy group) were retrospectively reviewed and compared with patients who underwent cementless THA without any antecedent surgery for ONFH during the same period (primary group)...
April 27, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28514285/association-of-abcb1-c3435t-polymorphism-with-the-susceptibility-to-osteonecrosis-of-the-femoral-head-a-meta-analysis
#16
REVIEW
Yu Zhang, Hui Xie, Dewei Zhao, Benjie Wang, Lei Yang, Qingyu Meng
BACKGROUND AND OBJECTIVE: The exploration for the etiology of osteonecrosis of the femoral head (ONFH) has got some promising findings, but the morbidity of ONFH is still not under control. The C3435T polymorphism of ATP-binding cassette subfamily B member 1 (ABCB1) gene has been reported to possess significant influence on ONFH onset, but relevant outcomes remain conflicting rather than conclusive. Therefore, a meta-analysis was useful to pool these results together for a more reliable conclusion...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28498798/differential-expression-of-mir-195-5p-in-collapse-of-steroid-induced-osteonecrosis-of-the-femoral-head
#17
Pengfei Li, Pei Zhai, Zengjie Ye, Peng Deng, Yueguang Fan, Yirong Zeng, Zhihui Pang, Jianchun Zeng, Jie Li, Wenjun Feng
BACKGROUND: Femoral head collapse is a key reference point for determining a treatment regimen of femoral head osteonecrosis. However, there are no effective preventive measures and the efficacy of hip-preserving surgery is unsatisfactory due to the unclear mechanism of collapse. This study aimed to identify and validate miRNAs differentially expressed in collapse and non-collapse areas of the osteonecrotic femoral head, and to predict the target genes and pathways of these miRNAs. RESULTS: Nine samples passed the quality control test...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28497454/efficacy-of-core-decompression-for-treatment-of-canine-femoral-head-osteonecrosis-induced-by-arterial-ischaemia-and-venous-congestion
#18
Yupeng Liu, Dewei Zhao, Weiming Wang, Yao Zhang, Benjie Wang, Zhigang Li
METHODS: 40 healthy mixed-breed dogs were randomly divided into 2 groups, arterial ischaemia (AI) and venous congestion (VC), each containing 20 dogs. The dogs underwent a procedure where the deep femoral artery or deep femoral vein was ligated randomly on the left or right side to establish the femoral head osteonecrosis model. 13 dogs from each group, AI and VC, were randomly selected for subsequent study. 3 dogs were randomly chosen from each group to receive core decompression (CD) every 2 weeks for a total of 4 sessions...
May 10, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28474152/free-vascularized-fibular-grafting-improves-vascularity-compared-with-core-decompression-in-femoral-head-osteonecrosis-a-randomized-clinical-trial
#19
Lu Cao, Changan Guo, Jifei Chen, Zenggan Chen, Zuoqin Yan
BACKGROUND: Management of osteonecrosis of the femoral head remains challenging. Core decompression and free vascularized fibular grafting are commonly used surgical procedures for treatment of osteonecrosis of the femoral head. Few studies, however, have compared these two procedures in a randomized controlled study, in terms of improved vascularity of the femoral head, progression of disease, or hip scores. QUESTION/PURPOSES: (1) What is the effect of core decompression and fibular grafting on vascularity of the femoral head as measured by single-photon emission CT (SPECT)/CT? (2) Does one of these two methods lead to greater progression of Association Research Circulation Osseous (ARCO) stage as determined by serial MRI? (3) What is the relationship between the change in vascularity of the femoral head and hip function as measured by the Harris hip score (HHS) and progression to THA as an endpoint? METHODS: A randomized controlled trial was performed between June 2010 and October 2012 at Zhongshan Hospital, Fudan University...
May 4, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28459353/role-of-coagulopathy-in-glucocorticoid-induced-osteonecrosis-of-the-femoral-head
#20
Qiankun Zhang, Jin L V, Lie Jin
The two major theories of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH) are apoptosis and ischaemia. The traditional theory implicates ischaemia as the main aetiological factor because the final common pathway of ONFH is interruption of blood supply to the bone. The most common causes of interruption of blood supply include fat embolism and coagulation disorders. GCs can directly or indirectly lead to coagulation disorders, producing a hypercoagulable state, followed by poor blood flow, ischaemia, and eventually ONFH...
January 1, 2017: Journal of International Medical Research
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