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JOURNAL ARTICLE
Yiping Dong, Congcong Luo, Ning Zhang, Ruonan You, Qiang Yuan, Wuyin Li, Ying Zhang
OBJECTIVE: To analyze the correlation between postoperative complications and combined deflection angle classification adduction type (CDAC-ADT) of femoral neck fractures after cannulated screw internal fixation. METHODS: The clinical data of 121 patients with CDAC-ADT femoral neck fracture admitted between January 2018 and December 2021 and met the selected criteria were retrospectively analyzed. There were 69 males and 52 females, the age ranged from 19 to 79 years (mean, 48...
April 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
#2
JOURNAL ARTICLE
Daniel Hameed, Jeremy A Dubin, Sandeep S Bains, Mallory C Moore, Shawn C Standard, Michael A Mont
INTRODUCTION: Total hip arthroplasty (THA) for dislocated hips (Crowe IV dysplasia) presents unique challenges. Conventional approaches involve subtrochanteric osteotomies, but are complex with additional fixation and potentially lead to limb-length discrepancies, nerve palsies, and other complications. An alternative strategy is a staged approach, where the femoral head (or remnant) is gradually lowered (distraction technique) to align with the true acetabulum over a period of time, followed by a second-stage anatomically acetabular-positioned THA...
April 15, 2024: Journal of Arthroplasty
#3
REVIEW
Madhan Jeyaraman, Filippo Migliorini, Sangeetha Balaji, Swaminathan Ramasubramanian, Tarun Jayakumar, Naveen Jeyaraman
The use of whole-body cryotherapy (WBC) for musculoskeletal ailments is growing. WBC, involving brief exposure to extremely low temperatures, is increasingly used for its analgesic, anti-inflammatory, and antioxidant effects. The paper examines the physiological impacts of WBC on cardiovascular, musculoskeletal, hematologic, hormonal, and metabolic systems. Specific orthopaedic applications discussed include its role in the management of fractures, osteoarthritis, osteonecrosis of the femoral head, osteomyelitis, adhesive capsulitis, tendinopathies, rheumatic pathologies, chronic pain syndromes, and fibromyalgia...
April 17, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
#4
JOURNAL ARTICLE
Na Yuan, Weiying Zhang, Weizhou Yang, Wenchen Ji, Jia Li
Inflammatory reactions are involved in the development of steroid-induced osteonecrosis of the femoral head(ONFH). Studies have explored the therapeutic efficacy of inhibiting inflammatory reactions in steroid-induced ONFH and revealed that inhibiting inflammation may be a new strategy for preventing the development of steroid-induced ONFH. Exosomes derived from M2 macrophages(M2-Exos) display anti-inflammatory properties. This study aimed to examine the preventive effect of M2-Exos on early-stage steroid-induced ONFH and explore the underlying mechanisms involved...
April 16, 2024: Journal of Orthopaedic Surgery and Research
#5
JOURNAL ARTICLE
Qun Li, Zhi-Xing Hu, Yan-Qiong Zhang, Yan Jia, Chao Yang, Li-Li Wang, Jia-Lin Wang, Qian-Qian Yan, Wei-Heng Chen, Na Lin, Chun-Fang Liu
A research strategy combining transcriptome data mining and experimental verification was adopted to identify the marker genes characterizing the syndrome elements of phlegm, stasis, and deficiency in steroid-induced osteonecrosis of the femoral head(SONFH). Firstly, the common differentially expressed gene sets of SONFH with the syndromes of phlegm-stasis obstructing collaterals, vessel obstruction, and liver-kidney deficiency were obtained from the clinical transcriptomic analysis of a previous study. The differential expression trend analysis and functional gene mining were then employed to predict the candidate marker gene sets representing phlegm, stasis, and deficiency...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#6
JOURNAL ARTICLE
Xiaoxiao Zhou, Shengyang Guo, Wenjun Pan, Linyuan Zhang, Houlin Ji, Yang Yang
OBJECTIVE: Femoral neck fractures (FNFs) are among the most common fractures in elderly individuals. Surgery is the main treatment for FNFs, and osteonecrosis of the femoral head (ONFH) is one of the unacceptable complications. This study aimed to assess both the clinical and radiological outcomes in patients with FNFs treated with three parallel cannulated screws and to identify relationship between screws position and ONFH. PATIENTS AND METHODS: A total of 100 patients who were treated with closed reduction and fixed with 3 parallel cannulated screws met the inclusion criteria between January 2014 and December 2020 at authors' institution...
April 13, 2024: BMC Musculoskeletal Disorders
#7
REVIEW
Wojciech Konarski, Tomasz Poboży, Klaudia Konarska, Andrzej Śliwczyński, Ireneusz Kotela, Jan Krakowiak
Osteonecrosis is a debilitating condition characterized by the loss of blood supply to the bones, leading to bone death. This condition can impact various bones, including the jaw, which significantly affects patients' quality of life by causing difficulties in swallowing, feeding, chewing, and speaking, along with swollen, painful mucous membranes and chronic sinusitis. Osteonecrosis can arise due to treatment with antiresorptive drugs. However, there is a growing number of reports of osteonecrosis following novel targeted anti-cancer treatments, such as tyrosine kinase inhibitors (TKIs) and biological therapies...
March 25, 2024: Journal of Clinical Medicine
#8
JOURNAL ARTICLE
Qing-Yuan Zheng, Ye Tao, Lei Geng, Peng Ren, Ming Ni, Guo-Qiang Zhang
OBJECTIVE: Osteonecrosis of the femoral head (ONFH) is a severe disease that primarily affects the middle-aged population, imposing a significant economic and social burden. Recent research has linked the progression of non-traumatic osteonecrosis of the femoral head (NONFH) to the composition of the gut microbiota. Steroids and alcohol are considered major contributing factors. However, the relationship between NONFH caused by two etiologies and the microbiota remains unclear. In this study, we examined the gut microbiota and fecal metabolic phenotypes of two groups of patients, and analyzed potential differences in the pathogenic mechanisms from both the microbial and metabolic perspectives...
April 12, 2024: Journal of Orthopaedic Surgery and Research
#9
JOURNAL ARTICLE
Suhas Sondur, Govid Vj, Shakti Prasad Das
The anti-inflammatory and immunosuppressive properties of steroids allow their use in a wide variety of rheumatological diseases, asthma, inflammatory bowel disease, cancer therapy, and severe viral infections. Though life-saving or organ-saving, long-term clinical use leads to a vast array of complications. Osteoporosis is the most common orthopedic side effect of steroid abuse, while osteonecrosis is a rare occurrence. The risk of osteonecrosis appears to be dose and duration dependent, but several patient factors also play a major role and usually affect the femoral head followed by the knee joint...
March 2024: Clinical Medicine & Research
#10
JOURNAL ARTICLE
Jiaqi Shi, Li Chen, Xu Wang, Xin Ma
Steroid-induced osteonecrosis of the femoral head (ONFH) is a serious complication caused by long-term or excessive use of glucocorticoids. The present study aimed to ascertain the effects of tripartite motif-containing protein 21 (TRIM21) on the process of steroid-induced ONFH and its hidden action mechanism. TRIM21 expression in dexamethasone (Dex)-treated mouse MC3T3-E1 preosteoblast cells was examined using reverse transcription-quantitative PCR and western blotting. The Cell Counting Kit-8 (CCK-8) method and lactate dehydrogenase release assay were used to respectively measure cell viability and injury...
May 2024: Experimental and Therapeutic Medicine
#11
JOURNAL ARTICLE
Fumihiro Yoshimura, Kenichiro Doi, Koichi Kinoshita, Hajime Seo, Taiki Matsunaga, Takuaki Yamamoto
Coronavirus disease 2019 is known to cause severe acute respiratory syndrome, and serious cases need to be treated with corticosteroids. Herein, we report an 87-year-old woman who developed bilateral osteonecrosis of the femoral head after corticosteroid treatment for coronavirus disease 2019-related pneumonia. Sixteen months after treatment, she developed right hip pain without any evidence of trauma. A diagnosis of bilateral osteonecrosis of the femoral head was made based on sclerotic bands on plain radiographs and low-signal bands on T1-weighted magnetic resonance images...
April 8, 2024: Skeletal Radiology
#12
JOURNAL ARTICLE
Peng Shang, Ying Liu, Jie Ren, Qingqing Liu, Haobo Song, Junqing Jia, Qiang Liu
This study is to probe into the meaning of serum miR-532-5p in nontraumatic osteonecrosis of the femoral head (ONFH), and a molecular mechanism of miR-532-5p in the development of nontraumatic ONFH. This study enrolled 96 patients diagnosed with nontraumatic ONFH and 96 patients with femoral neck fracture. The levels of miR-532-5p, ABL1, MMP-3, MMP-13, and cleaved-caspase3 were determined. Radiographic progression was assessed by ARCO staging system. Visual analog scale (VAS) and Harris hip score (HHS) were employed for evaluation of the symptomatic severity of nontraumatic ONFH...
2024: Open Medicine (Warsaw, Poland)
#13
JOURNAL ARTICLE
Yusuke Ayabe, Goro Motomura, Satoshi Ikemura, Ryosuke Yamaguchi, Takeshi Utsunomiya, Noriko Yamamoto, Hidenao Tanaka, Satoshi Hamai, Shinya Kawahara, Yasuharu Nakashima
BACKGROUND: This study assessed the hip survival rate and patient-reported outcome measures (PROMs) of transtrochanteric curved varus osteotomy (CVO) for osteonecrosis of the femoral head (ONFH) compared with those of conservative management. METHODS: The CVO group comprised 32 consecutive patients (39 hips) who underwent CVO for ONFH between 2000 and 2011. The conservative group consisted of 36 consecutive patients (37 hips) who were managed conservatively for at least 1 year after collapse and who had ONFH classified by the Japanese Investigation Committee of Health and Welfare as type B or C1, for which CVO is indicated...
April 2, 2024: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
#14
JOURNAL ARTICLE
Cameron Bell, Alborz Feizi, Gregory R Roytman, Alim F Ramji, Steven M Tommasini, Daniel H Wiznia
BACKGROUND: Femoral head avascular necrosis (AVN), or death of femoral head tissue due to a lack of blood supply, is a leading cause of total hip replacement for non-geriatric patients. Core decompression (CD) is an effective treatment to re-establish blood flow for patients with AVN. Techniques aimed at improving its efficacy are an area of active research. We propose the use of 3D printed drill guides to accurately guide therapeutic devices for CD. METHODS: Using femur sawbones, image processing software, and 3D modeling software, we created a custom-built device with pre-determined drill trajectories and tested the feasibility of the 3D printed drill guides for CD...
April 2, 2024: 3D Printing in Medicine
#15
Cheng-Ta Wu, Feng-Chih Kuo, Shih-Hsiang Yen, Po-Chun Lin, Jun-Wen Wang, Mel S Lee
No abstract text is available yet for this article.
March 29, 2024: Journal of Arthroplasty
#16
JOURNAL ARTICLE
Junichi Nakamura, Wakaba Fukushima, Wataru Ando, Shigeo Hagiwara, Yuya Kawarai, Yuki Shiko, Yohei Kawasaki, Takashi Sakai, Kazuya Ito, Yoshiya Arishima, Etsuo Chosa, Yusuke Fujimoto, Kazuo Fujiwara, Yukiharu Hasegawa, Shinya Hayashi, Takashi Imagama, Yutaka Inaba, Yasuyuki Ishibashi, Yasuhiro Ishidou, Hideya Ito, Hiroshi Ito, Juji Ito, Tetsuya Jinno, Tamon Kabata, Nobuhiro Kaku, Ayumi Kaneuji, Shunji Kishida, Seneki Kobayashi, Setsuro Komiya, Toshikazu Kubo, Tokifumi Majima, Naohiko Mashima, Masaaki Mawatari, Hidenobu Miki, Kazumasa Miyatake, Goro Motomura, Satoshi Nagoya, Hiroaki Nakamura, Yoshihide Nakamura, Ryosuke Nakanishi, Yasuharu Nakashima, Satoshi Nakasone, Takashi Nishii, Takayuki Nishiyama, Yoichi Ohta, Kenji Ohzono, Makoto Osaki, Kan Sasaki, Taisuke Seki, Takaaki Shishido, Takeshi Shoji, Akihiro Sudo, Michiaki Takagi, Daisuke Takahashi, Masaki Takao, Sakae Tanaka, Takeyuki Tanaka, Tomonori Tetsunaga, Keiichiro Ueshima, Kengo Yamamoto, Takuaki Yamamoto, Yuji Yamamoto, Takuma Yamasaki, Yuji Yasunaga, Nobuhiko Sugano
OBJECTIVES: This study documents the time elapsed from the diagnosis of osteonecrosis of the femoral head (ONFH) to surgery, exploring the factors that influence ONFH severity. DESIGN: Retrospective observational study of a nationwide database. SETTING: The Kaplan-Meier method with log-rank tests was applied to examine the period from definitive diagnosis of ONFH to surgery using any surgery as the end point. For bilateral cases, the date of the first surgery was the endpoint...
March 29, 2024: BMJ Open
#17
JOURNAL ARTICLE
Gang Wang, Chao Ma, Liang Mo, Jiazhi Chen, Jinbo Yuan, Jiake Xu, Wei He
BACKGROUND: Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common bone and joint disease. There is currently a lack of effective treatment for GIONFH, and the disease progression may lead to total hip arthroplasty (THA). The exact mechanism of GIONFH pathogenesis remains unsettled, and emerging evidence indicates that the overactivation of osteoclasts plays a pivotal role in the occurrence and progression of this condition. Our previous study has shown that cycloastragenol (CAG), a triterpenoid saponin with multiple bioactivities, is a natural osteoclast inhibitor and has a protective effect on bone loss...
March 2024: Journal of Orthopaedic Translation
#18
Joo-Hyoun Song, Young Wook Lim, Se-Won Lee, Hyun Woo Park, Howon Jeong, Seungbae Oh
INTRODUCTION: A fracture of the ceramic head in bipolar hemiarthroplasty using an inner polyliner has not been reported yet, and there seems to be no report of simultaneous breakage of the fourth-generation BIOLOX Delta ceramic head and liner in total hip arthroplasty. METHOD: A 44-year-old male patient underwent bipolar hemiarthroplasty using a third-generation BIOLOX Forte ceramic head 3 years and 9 months earlier for osteonecrosis of femoral head (ONFH) and visited our hospital due to a ceramic head fracture...
April 2024: Indian Journal of Orthopaedics
#19
REVIEW
Wenkai Shao, Ping Wang, Xiao Lv, Bo Wang, Song Gong, Yong Feng
Osteonecrosis of the femoral head (ONFH) is a disabling disease characterized by the disruption of the blood supply to the femoral head, leading to the apoptosis and necrosis of bone cells and subsequent joint collapse. Total hip arthroplasty is not optimal since most patients are young. Multiple risk factors contribute to osteonecrosis, including glucocorticoid (GC) usage, excessive alcohol intake, hypercholesterolemia, and smoking. Continuous stimulation by many variables causes a chronic inflammatory milieu, with clinical repercussions including endothelial dysfunction, leading to thrombosis, coagulopathy, and poor angiogenesis...
March 15, 2024: Biomedicines
#20
JOURNAL ARTICLE
Chuankai Shi, Xin Li, Yu Sun, Zhenwu Du, Guizhen Zhang, Zhenjia Che, Qingyu Li, Shiliang Song, Jing Guo, Haoyan Sun, Yang Song
The genes of Wnt/β-catenin pathway may have potential roles in fat accumulation of Non-traumatic osteonecrosis of the femoral head (ONFH), but the effects of their variants in the pathway on ONFH development have been remained unclear. To explore the potential roles of the variants in the development of ONFH, we completed the investigation of the paired interactions as well as their related biological functions of 17 variants of GSK3β, LRP5, and FRP4 genes etc. in the pathway. The genotyping of the 17 variants were finished by MASS ARRAY PLATFORM in a 560 ONFH case-control system...
March 27, 2024: Scientific Reports
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