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https://www.readbyqxmd.com/read/28975111/human-papillomavirus-in-head-and-neck-cancer-in-india-current-status-and-consensus-recommendations
#1
REVIEW
Vedang Murthy, Adnan Calcuttawala, Kirti Chadha, Anil d'Cruz, Arvind Krishnamurthy, Indranil Mallick, Sudhir Nair, Tanuja Teni, Sagar Pawar, Kaustav Talapatra, Asawari Patil, Amit Bhatt, Sanjoy Chatterjee, Monali Swain, Prasad Narayanan, Nikhil Ghadyalpatil, Manish Singhal, Moni Kuriakose, Kumar Prabhash, Jaiprakash Agarwal, Purvish Parikh
Human papillomavirus (HPV) associated head and neck squamous cell cancers (HNSCC) have become increasingly common in the West, but the same cannot be said about India. These cancers have a different biology and confer a better prognosis, however, its current role in the management of patients in India is not clearly defined. At the 35(th) Indian Cooperative Oncology Network conference held in September 2016, a panel of radiation, surgical and medical oncologists, pathologists, and basic scientists from across the country having experience in clinical research with respect to HPV in HNSCC reviewed the available literature from India...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28947954/bh3-mimetic-obatoclax-gx15-070-mediates-mitochondrial-stress-predominantly-via-mcl-1-inhibition-and-induces-autophagy-dependent-necroptosis-in-human-oral-cancer-cells
#2
Prasad Sulkshane, Tanuja Teni
We have previously reported overexpression of antiapoptotic MCL-1 protein in human oral cancers and its association with therapy resistance and poor prognosis, implying it to be a potential therapeutic target. Hence, we investigated the efficacy and mechanism of action of Obatoclax, a BH3 mimetic pan BCL-2 inhibitor in human oral cancer cell lines. All cell lines exhibited high sensitivity to Obatoclax with complete clonogenic inhibition at 200-400 nM concentration which correlated with their MCL-1 expression...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28754170/pattern-and-predictors-of-medicine-use-among-households-in-gondar-town-northwestern-ethiopia-a-community-based-medicine-utilization-study
#3
Fitsum Sebsibe Teni, Eshetie Melese Birru, Abdrrahman Shemsu Surur, Assefa Belay, Dawit Wondimsigegn, Dessalegn Asmelashe Gelayee, Zewdneh Shewamene
BACKGROUND: Medicine use can be influenced by several factors. Health managers need specific information about irrational use of medicines, in order to identify opportunities to enhance rational use of medicines in their communities. This study aimed to assess the pattern and factors associated with household medicine use in Gondar town, northwestern Ethiopia. METHODS: An interviewer-administered cross-sectional survey was conducted on 771 households, carried out between 5 April and 6 May 2015...
July 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28731009/interlesional-flip-flop-between-68-ga-dotatate-and-fdg-pet-ct-in-thyroglobulin-elevated-negative-iodine-scintigraphy-tenis-syndrome
#4
Sandip Basu, Ashwini Kalshetty, Preeti Fargose
No abstract text is available yet for this article.
January 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28712490/pneumococcal-vaccination-for-splenectomized-patients-with-thalassemia-major-in-indonesia
#5
Teny Tjitra Sari, Arwin Ali P Akib, Djajadiman Gatot, Alida Roswita Harahap, Saptawati Bardosono, Sri Rezeki S Hadinegoro
INTRODUCTION: Streptococcus pneumoniae is a capsulated bacterium that can cause severe infection in patients with thalassemia major, particularly those who have undergone splenectomy. The absence of the spleen as well as zinc deficiency in splenectomized patients with thalassemia major increases the possibility of developing invasive pneumococcal infection. The aims of this study are to evaluate pneumococcal IgG levels following PCV and PPV immunizations and the effect of zinc supplementation on qualitative specific immune responses in splenectomized patients with thalassemia...
July 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28421118/pattern-of-traditional-medicine-utilization-among-hiv-aids-patients-on-antiretroviral-therapy-at-a-university-hospital-in-northwestern-ethiopia-a-cross-sectional-study
#6
Abyot Endale Gurmu, Fitsum Sebsibe Teni, Wondmagegn Tamiru Tadesse
The objective of this study was to assess traditional, complementary, and alternative medicine (TCAM) utilization pattern among HIV/AIDS patients on antiretroviral therapy at University of Gondar Comprehensive Specialized Hospital. Materials and Methods. Data on sociodemographic profile and clinical and TCAM utilization were collected using a structured, pretested questionnaire from April 01 to May 28, 2014, through interviews with patients. Data on CD4 count, HIV stage, and ART regimen were collected from patient records...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28346249/usefulness-of-68ga-dota-rgd-%C3%AE-v%C3%AE-3-pet-ct-imaging-in-thyroglobulin-elevation-with-negative-iodine-scintigraphy
#7
Rakhee Vatsa, Jaya Shykla, Bhagwant Rai Mittal, Priya Bhusari, Apurva Sood, Rajender Kumar Basher, Anish Bhattacharya
TENIS (thyroglobulin elevation with negative iodine scintigraphy) syndrome in patients with differentiated thyroid carcinoma is not a rare finding. In such patients, F-FDG PET/CT can help in disease evaluation. RGD tripeptide, used for imaging angiogenesis, may also help in disease detection in patients with negative radioiodine whole-body scan. We present 1 such case in whom Ga-RGD tripeptide imaging was helpful in disease detection in the setting of negative radioiodine whole-body scan.
June 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28274219/a-household-survey-of-medicine-storage-practices-in-gondar-town-northwestern-ethiopia
#8
Fitsum Sebsibe Teni, Abdrrahman Shemsu Surur, Assefa Belay, Dawit Wondimsigegn, Dessalegn Asmelashe Gelayee, Zewdneh Shewamene, Befikadu Legesse, Eshetie Melese Birru
BACKGROUND: Household surveys are crucial to get accurate information on how medicines are acquired, and used by consumers, as they provide the best evidence in the area. The objective of this study was to document household medicine storage practices in Gondar town, northwestern Ethiopia. METHODS: A cross-sectional household survey was conducted from April 5 to May 6, 2015. In the study, 809 households were surveyed from four sub-cities in the town selected through multistage sampling with 771 included in the final analysis...
March 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28244466/human-papillomavirus-p16-positive-head-and-neck-cancer-in-india-prevalence-clinical-impact-and-influence-of-tobacco-use
#9
V Murthy, M Swain, T Teni, S Pawar, P Kalkar, A Patil, A Chande, S Ghonge, S G Laskar, T Gupta, A Budrukkar, J Agrawal
BACKGROUND: Limited data are available on the prevalence and prognostic significance of human papillomavirus (HPV) in squamous cell carcinoma of head and neck (SCCHN) in the Indian population. AIM: The present study aimed to determine the prevalence of HPV and p16 in an Indian cohort of SCCHN and assess their correlation and influence of tobacco use on patient outcomes. MATERIALS AND METHODS: The p16 and HPV status of 170 patients of SCCHN treated with curative chemoradiotherapy was determined using immunohistochemistry and polymerase chain reaction, respectively, and further correlated with their demographic characteristics...
July 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28120116/urine-drug-screen-findings-among-ambulatory-oncology-patients-in-a-supportive-care-clinic
#10
Sherri Rauenzahn, Adam Sima, Brian Cassel, Danielle Noreika, Teny Henry Gomez, Lynn Ryan, Carl E Wolf, Luke Legakis, Egidio Del Fabbro
PURPOSE: Professional organizations provide no guidelines regarding assessment and management of opioid abuse risk in cancer. Universal precautions (UP) developed for non-cancer pain, include assessments for aberrant behavior, screening questionnaires, and urine drug screens (UDS). The role of UDS for identifying opioid abuse risk in cancer is uncertain. Our aim is to characterize inappropriate UDS, and identify a potential role for UDS in therapeutic decision-making. METHODS: An observational retrospective chart review of 232 consecutive supportive care clinic patients were seen during the study...
June 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28036235/biomarkers-for-uranium-risk-assessment-for-the-development-of-the-cure-concerted-uranium-research-in-europe-molecular-epidemiological-protocol
#11
REVIEW
Yann Guéguen, Laurence Roy, Sabine Hornhardt, Christophe Badie, Janet Hall, Sarah Baatout, Eileen Pernot, Ladislav Tomasek, Olivier Laurent, Teni Ebrahimian, Chrystelle Ibanez, Stephane Grison, Sylwia Kabacik, Dominique Laurier, Maria Gomolka
Despite substantial experimental and epidemiological research, there is limited knowledge of the uranium-induce health effects after chronic low-dose exposures in humans. Biological markers can objectively characterize pathological processes or environmental responses to uranium and confounding agents. The integration of such biological markers into a molecular epidemiological study would be a useful approach to improve and refine estimations of uranium-induced health risks. To initiate such a study, Concerted Uranium Research in Europe (CURE) was established, and involves biologists, epidemiologists and dosimetrists...
January 2017: Radiation Research
https://www.readbyqxmd.com/read/27970934/management-of-children-s-acute-diarrhea-by-community-pharmacies-in-five-towns-of-ethiopia-simulated-client-case
#12
T B Abebe, T M Abegaz, S A Belachew, B M Gebresilassie, F S Teni, H G Woldie
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27863564/designing-and-developing-pet-based-precision-model-in-thyroid-carcinoma-the-potential-avenues-for-a-personalized-clinical-care
#13
REVIEW
Sandip Basu, Rahul Vithalrao Parghane
This communication enumerates the current uses and potential areas where PET could be clinically utilized for developing "precision medicine" type model in thyroid carcinoma. (1) In routine clinics, PET imaging (with fluorodeoxyglucose [FDG]) is utilized to investigate patients of differentiated thyroid carcinoma (DTC) with high thyroglobulin and negative iodine scintigraphy (TENIS) and in medullary carcinoma thyroid (MCT) when the tumor markers (eg, calcitonin and carcino embryonic antigen [CEA]) are raised postoperatively (PET with FDG, (68)Ga-DOTA-NOC/TATE, FDOPA)...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27834723/evolution-of-papillary-thyroid-carcinoma-into-tall-cell-variant-and-tenis-syndrome
#14
Avik Chakraborty, S V Kane, Yogita Pawer, Sandip Basu
We herein report an unusual case of a 55-y-old woman with papillary carcinoma of the thyroid, who presented with multiple recurrences, with its subsequent evolution to tall cell variant and thyroglobulin-elevated negative iodine scintigraphy (TENIS) syndrome. During the course of the disease the lesions became non-iodine-concentrating with an increased proportion of tall cells and evidence of local and distant metastasis. Molecular analysis of the tissue specimen demonstrated BRAF(V600E) and I582 M mutations along with upregulation of tumor markers in metastatic tissue...
December 2016: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27741240/smad2-and-smad3-regulate-chondrocyte-proliferation-and-differentiation-in-the-growth-plate
#15
Weiguang Wang, Buer Song, Teni Anbarchian, Anna Shirazyan, Joshua E Sadik, Karen M Lyons
TGFβs act through canonical and non-canonical pathways, and canonical signals are transduced via Smad2 and Smad3. However, the contribution of canonical vs. non-canonical pathways in cartilage is unknown because the role of Smad2 in chondrogenesis has not been investigated in vivo. Therefore, we analyzed mice in which Smad2 is deleted in cartilage (Smad2CKO), global Smad3-/- mutants, and crosses of these strains. Growth plates at birth from all mutant strains exhibited expanded columnar and hypertrophic zones, linked to increased proliferation in resting chondrocytes...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27507051/bh3-mimetic-obatoclax-gx15-070-mediates-mitochondrial-stress-predominantly-via-mcl-1-inhibition-and-induces-autophagy-dependent-necroptosis-in-human-oral-cancer-cells
#16
Prasad Sulkshane, Tanuja Teni
We have previously reported overexpression of antiapoptotic MCL-1 protein in human oral cancers and its association with therapy resistance and poor prognosis, implying it to be a potential therapeutic target. Hence, we investigated the efficacy and mechanism of action of Obatoclax, a BH3 mimetic pan BCL-2 inhibitor in human oral cancer cell lines. All cell lines exhibited high sensitivity to Obatoclax with complete clonogenic inhibition at 200-400 nM concentration which correlated with their MCL-1 expression...
August 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27505875/geographic-tongue
#17
Ceena Neena Jacob, Teny Mathew John, Jayaprakash R
No abstract text is available yet for this article.
August 2016: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/27493262/grouping-of-metastatic-thyroid-carcinoma-by-molecular-imaging-features-to-allow-for-individualized-treatment-with-emphasis-on-the-tenis-syndrome
#18
Sandip Basu, Rahul Vithalrao Parghane
The process of radioiodine ((131)I) refractoriness, dedifferentiation, and development of thyroglobulin elevation and negative iodine scintigraphy (TENIS) syndrome in metastatic differentiated thyroid carcinoma (DTC) could be viewed as a disease continuum rather than a single event or an all-or-none phenomenon. In this report, the important role of molecular functional imaging in systematically exploring the disease biology and course of metastatic DTC is presented. Making this role the base, this report proposes a novel clinical classification for TENIS syndrome using molecular functional imaging...
September 2016: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27317760/warfarin-improves-neuropathy-in-monoclonal-gammopathy-of-undetermined-significance
#19
Teny Henry Gomez, Beata Holkova, Danielle Noreika, Egidio Del Fabbro
We report a case of a 60-year-old man who was referred to a palliative care clinic with monoclonal gammopathy of undetermined significance (MGUS)-associated neuropathy, responding to a therapeutic trial of warfarin. Electromyography showed distal symmetric sensory axonal neuropathy. The patient reported having had improvement of his neuropathic symptoms while taking warfarin postoperatively for thromboprophylaxis 1 year prior, and recurrence of his symptoms after the warfarin was discontinued. The patient was rechallenged with a trial of warfarin, targeting an international normalised ratio of 1...
June 17, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27216280/management-of-headache-and-associated-factors-among-undergraduate-medicine-and-health-science-students-of-university-of-gondar-north-west-ethiopia
#20
Eshetie Melese Birru, Zenahebezu Abay, Mohammedbrhan Abdelwuhab, Abebe Basazn, Betelhem Sirak, Fitsum Sebsibe Teni
BACKGROUND: The headache disorders, namely, migraine and tension type headache and the associated analgesic consumption is badly underestimated and thus makes a major current public health problem. The objective of this study was to determine the prevalence of migraine and tension type headaches and the associated management options used among undergraduate students of College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. METHOD: Institution based cross sectional study was conducted among 720 students in May, 2014...
2016: Journal of Headache and Pain
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