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https://www.readbyqxmd.com/read/27863564/designing-and-developing-pet-based-precision-model-in-thyroid-carcinoma-the-potential-avenues-for-a-personalized-clinical-care
#1
REVIEW
Sandip Basu, Rahul Vithalrao Parghane
This communication enumerates the current uses and potential areas where PET could be clinically utilized for developing "precision medicine" type model in thyroid carcinoma. (1) In routine clinics, PET imaging (with fluorodeoxyglucose [FDG]) is utilized to investigate patients of differentiated thyroid carcinoma (DTC) with high thyroglobulin and negative iodine scintigraphy (TENIS) and in medullary carcinoma thyroid (MCT) when the tumor markers (eg, calcitonin and carcino embryonic antigen [CEA]) are raised postoperatively (PET with FDG, (68)Ga-DOTA-NOC/TATE, FDOPA)...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27834723/evolution-of-papillary-thyroid-carcinoma-into-tall-cell-variant-and-tenis-syndrome
#2
REVIEW
Avik Chakraborty, S V Kane, Yogita Pawer, Sandip Basu
We herein report an unusual case of a 55-y-old woman with papillary carcinoma of the thyroid, who presented with multiple recurrences, with its subsequent evolution to tall cell variant and thyroglobulin-elevated negative iodine scintigraphy (TENIS) syndrome. During the course of the disease the lesions became non-iodine-concentrating with an increased proportion of tall cells and evidence of local and distant metastasis. Molecular analysis of the tissue specimen demonstrated BRAF(V600E) and I582 M mutations along with upregulation of tumor markers in metastatic tissue...
December 2016: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27741240/smad2-and-smad3-regulate-chondrocyte-proliferation-and-differentiation-in-the-growth-plate
#3
Weiguang Wang, Buer Song, Teni Anbarchian, Anna Shirazyan, Joshua E Sadik, Karen M Lyons
TGFβs act through canonical and non-canonical pathways, and canonical signals are transduced via Smad2 and Smad3. However, the contribution of canonical vs. non-canonical pathways in cartilage is unknown because the role of Smad2 in chondrogenesis has not been investigated in vivo. Therefore, we analyzed mice in which Smad2 is deleted in cartilage (Smad2CKO), global Smad3-/- mutants, and crosses of these strains. Growth plates at birth from all mutant strains exhibited expanded columnar and hypertrophic zones, linked to increased proliferation in resting chondrocytes...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27507051/bh3-mimetic-obatoclax-gx15-070-mediates-mitochondrial-stress-predominantly-via-mcl-1-inhibition-and-induces-autophagy-dependent-necroptosis-in-human-oral-cancer-cells
#4
Prasad Sulkshane, Tanuja Teni
We have previously reported overexpression of antiapoptotic MCL-1 protein in human oral cancers and its association with therapy resistance and poor prognosis, implying it to be a potential therapeutic target. Hence, we investigated the efficacy and mechanism of action of Obatoclax, a BH3 mimetic pan BCL-2 inhibitor in human oral cancer cell lines. All cell lines exhibited high sensitivity to Obatoclax with complete clonogenic inhibition at 200-400 nM concentration which correlated with their MCL-1 expression...
August 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27505875/geographic-tongue
#5
Ceena Neena Jacob, Teny Mathew John, Jayaprakash R
No abstract text is available yet for this article.
August 2016: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/27493262/grouping-of-metastatic-thyroid-carcinoma-by-molecular-imaging-features-to-allow-for-individualized-treatment-with-emphasis-on-the-tenis-syndrome
#6
Sandip Basu, Rahul Vithalrao Parghane
The process of radioiodine ((131)I) refractoriness, dedifferentiation, and development of thyroglobulin elevation and negative iodine scintigraphy (TENIS) syndrome in metastatic differentiated thyroid carcinoma (DTC) could be viewed as a disease continuum rather than a single event or an all-or-none phenomenon. In this report, the important role of molecular functional imaging in systematically exploring the disease biology and course of metastatic DTC is presented. Making this role the base, this report proposes a novel clinical classification for TENIS syndrome using molecular functional imaging...
September 2016: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27317760/warfarin-improves-neuropathy-in-monoclonal-gammopathy-of-undetermined-significance
#7
Teny Henry Gomez, Beata Holkova, Danielle Noreika, Egidio Del Fabbro
We report a case of a 60-year-old man who was referred to a palliative care clinic with monoclonal gammopathy of undetermined significance (MGUS)-associated neuropathy, responding to a therapeutic trial of warfarin. Electromyography showed distal symmetric sensory axonal neuropathy. The patient reported having had improvement of his neuropathic symptoms while taking warfarin postoperatively for thromboprophylaxis 1 year prior, and recurrence of his symptoms after the warfarin was discontinued. The patient was rechallenged with a trial of warfarin, targeting an international normalised ratio of 1...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27216280/management-of-headache-and-associated-factors-among-undergraduate-medicine-and-health-science-students-of-university-of-gondar-north-west-ethiopia
#8
Eshetie Melese Birru, Zenahebezu Abay, Mohammedbrhan Abdelwuhab, Abebe Basazn, Betelhem Sirak, Fitsum Sebsibe Teni
BACKGROUND: The headache disorders, namely, migraine and tension type headache and the associated analgesic consumption is badly underestimated and thus makes a major current public health problem. The objective of this study was to determine the prevalence of migraine and tension type headaches and the associated management options used among undergraduate students of College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. METHOD: Institution based cross sectional study was conducted among 720 students in May, 2014...
2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27183135/concerted-uranium-research-in-europe-cure-toward-a-collaborative-project-integrating-dosimetry-epidemiology-and-radiobiology-to-study-the-effects-of-occupational-uranium-exposure
#9
Olivier Laurent, Maria Gomolka, Richard Haylock, Eric Blanchardon, Augusto Giussani, Will Atkinson, Sarah Baatout, Derek Bingham, Elisabeth Cardis, Janet Hall, Ladislav Tomasek, Sophie Ancelet, Christophe Badie, Gary Bethel, Jean-Marc Bertho, Ségolène Bouet, Richard Bull, Cécile Challeton-de Vathaire, Rupert Cockerill, Estelle Davesne, Teni Ebrahimian, Hilde Engels, Michael Gillies, James Grellier, Stephane Grison, Yann Gueguen, Sabine Hornhardt, Chrystelle Ibanez, Sylwia Kabacik, Lukas Kotik, Michaela Kreuzer, Anne Laure Lebacq, James Marsh, Dietmar Nosske, Jackie O'Hagan, Eileen Pernot, Matthew Puncher, Estelle Rage, Tony Riddell, Laurence Roy, Eric Samson, Maamar Souidi, Michelle C Turner, Sergey Zhivin, Dominique Laurier
The potential health impacts of chronic exposures to uranium, as they occur in occupational settings, are not well characterized. Most epidemiological studies have been limited by small sample sizes, and a lack of harmonization of methods used to quantify radiation doses resulting from uranium exposure. Experimental studies have shown that uranium has biological effects, but their implications for human health are not clear. New studies that would combine the strengths of large, well-designed epidemiological datasets with those of state-of-the-art biological methods would help improve the characterization of the biological and health effects of occupational uranium exposure...
June 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27127159/combining-the-glasgow-prognostic-score-and-serum-carbohydrate-antigen-19-9-level-improves-the-ability-to-predict-early-recurrence-in-resected-pancreatic-cancer-patients-receiving-adjuvant-gemcitabine
#10
Koji Numata, Soichiro Morinaga, Yusuke Katayama, Sho Sawazaki, Masakatsu Numata, Teni Godai, Akio Higuchi, Manabu Shiozawa, Yasushi Rino, Munetaka Masuda, Makoto Akaike
AIM: The aim of this study was to confirm the predictive/prognostic value of the preadjuvant Glasgow Prognostic Score (GPS) and carbohydrate antigen (CA) 19-9 level in pancreatic cancer patients receiving adjuvant gemcitabine (GEM) after surgery. PATIENTS AND METHODS: A total of 67 resected pancreatic cancer patients, treated with adjuvant GEM, were included. The GPS and CA19-9 level were calculated prior to administration of adjuvant therapy and were found to correlate with the outcomes and rate of early recurrence...
May 2016: Anticancer Research
https://www.readbyqxmd.com/read/27103810/management-of-children-s-acute-diarrhea-by-community-pharmacies-in-five-towns-of-ethiopia-simulated-client-case-study
#11
Tadesse Melaku Abegaz, Sewunet Admasu Belachew, Tamrat Befekadu Abebe, Begashaw Melaku Gebresilassie, Fitsum Sebsibe Teni, Habtamu Gebremeskel Woldie
BACKGROUND: Acute diarrhea is the major cause of child morbidity and mortality in low-income nations. It is the second most common cause of death among children <5 years of age globally. The indispensable role of community pharmacists is clearly observed in the prevention and treatment of diarrhea. However, there is a paucity of data on how community pharmacies manage acute childhood diarrhea cases in Ethiopia. This study aimed to evaluate the experience of community pharmacies in the management of acute diarrhea in northern Ethiopia...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27057386/prevalence-reasons-and-perceived-effects-of-khat-chewing-among-students-of-a-college-in-gondar-town-northwestern-ethiopia-a-cross-sectional-study
#12
F S Teni, A S Surur, A Hailemariam, A Aye, G Mitiku, A E Gurmu, B Tessema
BACKGROUND: The estimate of the number of people chewing Khat globally ranges from 5 to 10 million people. Its use may result in a variety of effects due to the different compounds in it with effects on the gastro-intestinal system and nervous system being the principal ones. AIM: To assess the prevalence, factors, and effects of Khat chewing among students of a college in Gondar town, northwestern Ethiopia. SUBJECTS AND METHODS: An institution-based cross-sectional study was conducted from 15(th) to 20(th) of April 2009 on a total sample of 424 students who were selected using stratified random sampling technique...
November 2015: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/26443755/biosynthesis-of-thiamin-pyrophosphate
#13
Christopher T Jurgenson, Steven E Ealick, Tadhg P Begley
The biosynthesis of thiamin pyrophosphate (TPP) in prokaryotes, as represented by the Escherichia coli and the Bacillus subtilis pathways, is summarized in this review. The thiazole heterocycle is formed by the convergence of three separate pathways. First, the condensation of glyceraldehyde 3-phosphate and pyruvate, catalyzed by 1-deoxy-D-xylulose 5-phosphate synthase (Dxs), gives 1-deoxy-D-xylulose 5-phosphate (DXP). Next, the sulfur carrier protein ThiS-COO- is converted to its carboxyterminal thiocarboxylate in reactions catalyzed by ThiF, ThiI, and NifS (ThiF and IscS in B...
August 2009: EcoSal Plus
https://www.readbyqxmd.com/read/26442090/mining-the-phytomicrobiome-to-understand-how-bacterial-coinoculations-enhance-plant-growth
#14
Maskit Maymon, Pilar Martínez-Hidalgo, Stephen S Tran, Tyler Ice, Karena Craemer, Teni Anbarchian, Tiffany Sung, Lin H Hwang, Minxia Chou, Nancy A Fujishige, William Villella, Jérôme Ventosa, Johannes Sikorski, Erin R Sanders, Kym F Faull, Ann M Hirsch
In previous work, we showed that coinoculating Rhizobium leguminosarum bv. viciae 128C53 and Bacillus simplex 30N-5 onto Pisum sativum L. roots resulted in better nodulation and increased plant growth. We now expand this research to include another alpha-rhizobial species as well as a beta-rhizobium, Burkholderia tuberum STM678. We first determined whether the rhizobia were compatible with B. simplex 30N-5 by cross-streaking experiments, and then Medicago truncatula and Melilotus alba were coinoculated with B...
2015: Frontiers in Plant Science
https://www.readbyqxmd.com/read/26346910/high-expression-of-survivin-and-its-splice-variants-survivin-%C3%AE-ex3-and-survivin-2-b-in-oral-cancers
#15
Rupa Mishra, Vinayak Palve, Sadhana Kannan, Sagar Pawar, Tanuja Teni
OBJECTIVES: We have previously reported inactivation of p53 in 46% of Indian patients with oral cancer. Survivin, a p53 target gene and an inhibitor of apoptosis protein (IAP), is overexpressed in several cancers, including oral cancers. Studies assessing the role of survivin and its splice variants in oral cancers are, however, rare. MATERIALS AND METHODS: The expression of 6 survivin isoforms in 4 oral cancer cell lines (AW8507, AW13516, UPCI-SCC040, UPCI-SCC029 B), a dysplastic oral cell line (DOK), 75 paired oral tumor and adjacent normal tissues, and 12 normal oral tissue samples from healthy individuals was analyzed by real-time PCR...
October 2015: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/26062912/satisfaction-of-clients-with-the-services-of-an-outpatient-pharmacy-at-a-university-hospital-in-northwestern-ethiopia-a-cross-sectional-study
#16
COMPARATIVE STUDY
Abdrrahman Shemsu Surur, Fitsum Sebsibe Teni, Genet Girmay, Elsabet Moges, Meseret Tesfa, Messele Abraha
BACKGROUND: Evaluation of patient/client satisfaction with pharmacy services as a crucial part of the health services through appropriate studies is important. This will help identify specific areas of the service which need improvement in realizing high quality pharmacy services in general and enhance the positive changes in the current pharmaceutical services provision in Ethiopia. The current study aimed at assessing the level of client satisfaction with the services of the outpatient pharmacy of Gondar University Referral Hospital (GURH) in northwestern Ethiopia...
2015: BMC Health Services Research
https://www.readbyqxmd.com/read/26049373/value-of-18f-fdg-pet-negativity-and-tg-suppressibility-as-markers-of-prognosis-in-patients-with-elevated-tg-and-131i-negative-differentiated-thyroid-carcinoma-tenis-syndrome
#17
Rohit Ranade, Purushottam Kand, Sandip Basu
AIMS: The aim of the study was to investigate the prognostic value of fluorine-18 fluorodeoxyglucose (18F-FDG) PET negativity and thyroglobulin (Tg) suppressibility in differentiated thyroid carcinoma patients with elevated Tg and a negative radioiodine scan. MATERIALS AND METHODS: The study population was selected from thyroid cancer patients registered at a large tertiary cancer care center for management and consisted of patients with metastatic thyroid cancer with elevated Tg on follow-up, negative 131I whole-body scan and negative 18F-FDG PET/computed tomography (CT) study...
October 2015: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/26046630/chronic-internal-exposure-to-low-dose-137cs-induces-positive-impact-on-the-stability-of-atherosclerotic-plaques-by-reducing-inflammation-in-apoe-mice
#18
Clélia Le Gallic, Yohann Phalente, Line Manens, Isabelle Dublineau, Marc Benderitter, Yann Gueguen, Stephanie Lehoux, Teni G Ebrahimian
After Chernobyl and Fukushima Daï Chi, two major nuclear accidents, large amounts of radionuclides were released in the environment, mostly caesium 137 (137Cs). Populations living in contaminated territories are chronically exposed to radionuclides by ingestion of contaminated food. However, questions still remain regarding the effects of low dose ionizing radiation exposure on the development and progression of cardiovascular diseases. We therefore investigated the effects of a chronic internal exposure to 137Cs on atherosclerosis in predisposed ApoE-/- mice...
2015: PloS One
https://www.readbyqxmd.com/read/25989850/defining-a-rational-step-care-algorithm-for-managing-thyroid-carcinoma-patients-with-elevated-thyroglobulin-and-negative-on-radioiodine-scintigraphy-tenis-considerations-and-challenges-towards-developing-an-appropriate-roadmap
#19
EDITORIAL
Sandip Basu, Mitali Dandekar, Amit Joshi, Anil D'Cruz
No abstract text is available yet for this article.
July 2015: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/25883512/assessment-of-the-structural-and-process-aspects-of-pharmaceutical-care-at-a-university-hospital-in-ethiopia
#20
Abdrrahman Shemsu Surur, Fitsum Sebsibe Teni, Genet Girmay, Elsabet Moges, Meseret Tesfa, Messele Abraha
OBJECTIVE: To assess the structural and process components of the pharmaceutical care at Gondar University Referral Hospital (GURH). MATERIALS AND METHODS: An institution-based cross-sectional study was conducted on all the four pharmacies at GURH from October 1 to December 31, 2013. By adopting data collection instruments from a previously done study, the structural aspects of the pharmacies were assessed using an observation checklist and the process of pharmaceutical care delivery using a self-administered questionnaire...
April 2015: Journal of Pharmacy & Bioallied Sciences
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