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https://www.readbyqxmd.com/read/29643194/quantitative-thresholds-enable-accurate-identification-of-clostridium-difficile-infection-by-the-luminex-xtag-gi-pathogen-panel
#1
Sixto M Leal, Elena B Popowitch, Kara J Levinson, Teny M John, Bethany Lehman, Maria Bueno Rios, Peter H Gilligan, Melissa B Miller
Clostridium difficile colonizes the gastrointestinal tract resulting in either asymptomatic carriage or a spectrum of diarrheal illness. If clinical suspicion for C. difficile is low, stool samples are often submitted for analysis by multiplex molecular assays capable of detecting multiple GI pathogens and some institutions do not report this organism due to concerns for high false positive rates. Since clinical disease correlates with organism burden and molecular assays yield quantitative data, we hypothesized that numerical cutoffs could be utilized to improve the specificity of the Luminex xTAG GI pathogen panel (GPP) for C...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29531508/gamma-low-dose-rate-ionizing-radiation-stimulates-adaptive-functional-and-molecular-response-in-human-aortic-endothelial-cells-in-a-threshold-dose-and-dose-rate-dependent-manner
#2
Juliana Vieira Dias, Celine Gloaguen, Dimitri Kereselidze, Line Manens, Karine Tack, Teni G Ebrahimian
A central question in radiation protection research is whether low-dose and low-dose-rate (LDR) exposures to ionizing radiation play a role in progression of cardiovascular disease. The response of endothelial cells to different LDR exposures may help estimate risk of cardiovascular disease by providing the biological mechanism involved. We investigated the effect of chronic LDR radiation on functional and molecular responses of human aorta endothelial cells (HAoECs). Human aorta endothelial cells were continuously irradiated at LDR (6 mGy/h) for 15 days and analyzed at time points when the cumulative dose reached 0...
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29496566/effects-of-repeated-potassium-iodide-administration-on-genes-involved-in-synthesis-and-secretion-of-thyroid-hormone-in-adult-male-rat
#3
Dalila Lebsir, Line Manens, Stephane Grison, Philippe Lestaevel, Teni Ebrahimian, David Suhard, Guillaume Phan, Isabelle Dublineau, Karine Tack, Marc Benderitter, Annick Pech, Jean-Rene Jourdain, Maâmar Souidi
BACKGROUND: A single dose of potassium iodide (KI) is recommended to reduce the risk of thyroid cancer during nuclear accidents. However in case of prolonged radioiodine exposure, more than one dose of KI may be necessary. This work aims to evaluate the potential toxic effect of repeated administration of KI. METHODS: Adult Wistar rats received an optimal dose of KI 1 mg/kg over a period of 1, 4 or 8 days. RESULTS: hormonal status (TSH, FT4) of treated rats was unaffected...
February 26, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29432341/rare-case-of-intratracheal-metastasis-detected-on-68ga-prostate-specific-membrane-antigen-pet-ct-scan-in-a-case-of-thyroglobulin-elevated-negative-iodine-scan-syndrome
#4
Arun Sasikumar, Ajith Joy, M R A Pillai, Karuna Elza Oommen, R Jayakumar
A 64-year-old woman underwent completion thyroidectomy with upper tracheal ring resection and right-sided neck dissection for papillary carcinoma of the thyroid infiltrating the trachea and was given I radioiodine treatment. Three years later, she presented with hemoptysis. On evaluation, she had increased serum thyroglobulin and negative iodine scan (TENIS). F-FDG PET/CT scan did not identify any site of disease. One year later, Ga-PSMA scan done revealed a moderate focal tracer-avid intratracheal soft tissue; biopsy revealed it to be metastatic papillary carcinoma of the thyroid...
April 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29423055/hyperplastic-thymus-with-increased-angiogenesis-is-correlated-with-elevated-serum-thyroglobulin-level-in-differentiated-thyroid-cancer-patients-with-tenis-syndrome
#5
Guangjian Zhang, Rui Gao, Yuanbo Wang, Yan Liu, Juan Li, Xi Jia, Yiqian Liang, Aimin Yang
Aims: To investigate the association between angiogenetic activity of hyperplastic thymus and serum thyroglobulin (Tg) level in differentiated thyroid carcinoma patients with thyroglobulin (Tg)-elevated Negative Iodine Scintigraphy (TENIS) Syndrome. Methods: A cohort of 30 consecutive patients who underwent total thyroidectomy followed by radioiodine ablation and had TENIS syndrome received integrin αvβ3 targeted imaging with 99mTc-HYNIC-PEG4-E[PEG4-c(RGDfk)]2 (99mTc-3PRGD2)...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29203175/impact-of-hpv-16-18-infection-on-clinical-outcomes-in-locally-advanced-cervical-cancers-treated-with-radical-radio-chemo-therapy-a-prospective-observational-study
#6
Umesh Mahantshetty, Tanuja Teni, Pushpa Naga, Chandni Hotwani, Sumuki Umesh, Sadhana Kannan, Vinod Hande, Sagar Pawar, Reena Engineer, Supriya Chopra, Kedar Deodhar, Amita Maheshwari, Lavanya Gurram, Sudeep Gupta, Shyam Kishore Shrivastava
OBJECTIVE: With an aim to investigate the impact of Human Papilloma Virus (HPV) 16/18 infection on clinical outcomes in locally advanced cervical cancers treated with radical radio (chemo) therapy, we undertook this prospective study. METHODS: Between May 2010 and April 2012, 150 histologically proven cervical cancer patients treated with radio (chemo) therapy were accrued. Cervical biopsies/brushings were collected at pre-treatment, end of treatment and at 3 monthly intervals up to 24months...
February 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29141626/health-related-quality-of-life-of-hiv-aids-patients-on-highly-active-anti-retroviral-therapy-at-a-university-referral-hospital-in-ethiopia
#7
Abdrrahman Shemsu Surur, Fitsum Sebsibe Teni, Wondwessen Wale, Yihenew Ayalew, Betel Tesfaye
BACKGROUND: Highly active antiretroviral therapy improves the longevity of patients living with HIV/AIDS. We conducted the study in order to assess health related quality of life of HIV/AIDS patients and the association of socio-demographic and disease related variables with health related quality of life. METHODS: Health facility based cross-sectional study among 400 HIV/AIDS patients taking highly active anti-retroviral therapy from Gondar University referral hospital was conducted...
November 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28975111/human-papillomavirus-in-head-and-neck-cancer-in-india-current-status-and-consensus-recommendations
#8
REVIEW
Vedang Murthy, Adnan Calcuttawala, Kirti Chadha, Anil d'Cruz, Arvind Krishnamurthy, Indranil Mallick, Sudhir Nair, Tanuja Teni, Sagar Pawar, Kaustav Talapatra, Asawari Patil, Amit Bhatt, Sanjoy Chatterjee, Monali Swain, Prasad Narayanan, Nikhil Ghadyalpatil, Manish Singhal, Moni Kuriakose, Kumar Prabhash, Jaiprakash Agarwal, Purvish Parikh
Human papillomavirus (HPV) associated head and neck squamous cell cancers (HNSCC) have become increasingly common in the West, but the same cannot be said about India. These cancers have a different biology and confer a better prognosis, however, its current role in the management of patients in India is not clearly defined. At the 35(th) Indian Cooperative Oncology Network conference held in September 2016, a panel of radiation, surgical and medical oncologists, pathologists, and basic scientists from across the country having experience in clinical research with respect to HPV in HNSCC reviewed the available literature from India...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28947954/bh3-mimetic-obatoclax-gx15-070-mediates-mitochondrial-stress-predominantly-via-mcl-1-inhibition-and-induces-autophagy-dependent-necroptosis-in-human-oral-cancer-cells
#9
Prasad Sulkshane, Tanuja Teni
We have previously reported overexpression of antiapoptotic MCL-1 protein in human oral cancers and its association with therapy resistance and poor prognosis, implying it to be a potential therapeutic target. Hence, we investigated the efficacy and mechanism of action of Obatoclax, a BH3 mimetic pan BCL-2 inhibitor in human oral cancer cell lines. All cell lines exhibited high sensitivity to Obatoclax with complete clonogenic inhibition at 200-400 nM concentration which correlated with their MCL-1 expression...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28754170/pattern-and-predictors-of-medicine-use-among-households-in-gondar-town-northwestern-ethiopia-a-community-based-medicine-utilization-study
#10
Fitsum Sebsibe Teni, Eshetie Melese Birru, Abdrrahman Shemsu Surur, Assefa Belay, Dawit Wondimsigegn, Dessalegn Asmelashe Gelayee, Zewdneh Shewamene
BACKGROUND: Medicine use can be influenced by several factors. Health managers need specific information about irrational use of medicines, in order to identify opportunities to enhance rational use of medicines in their communities. This study aimed to assess the pattern and factors associated with household medicine use in Gondar town, northwestern Ethiopia. METHODS: An interviewer-administered cross-sectional survey was conducted on 771 households, carried out between 5 April and 6 May 2015...
July 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28731009/interlesional-flip-flop-between-68-ga-dotatate-and-fdg-pet-ct-in-thyroglobulin-elevated-negative-iodine-scintigraphy-tenis-syndrome
#11
Sandip Basu, Ashwini Kalshetty, Preeti Fargose
No abstract text is available yet for this article.
January 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28712490/pneumococcal-vaccination-for-splenectomized-patients-with-thalassemia-major-in-indonesia
#12
Teny Tjitra Sari, Arwin Ali P Akib, Djajadiman Gatot, Alida Roswita Harahap, Saptawati Bardosono, Sri Rezeki S Hadinegoro
INTRODUCTION: Streptococcus pneumoniae is a capsulated bacterium that can cause severe infection in patients with thalassemia major, particularly those who have undergone splenectomy. The absence of the spleen as well as zinc deficiency in splenectomized patients with thalassemia major increases the possibility of developing invasive pneumococcal infection. The aims of this study are to evaluate pneumococcal IgG levels following PCV and PPV immunizations and the effect of zinc supplementation on qualitative specific immune responses in splenectomized patients with thalassemia...
July 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28421118/pattern-of-traditional-medicine-utilization-among-hiv-aids-patients-on-antiretroviral-therapy-at-a-university-hospital-in-northwestern-ethiopia-a-cross-sectional-study
#13
Abyot Endale Gurmu, Fitsum Sebsibe Teni, Wondmagegn Tamiru Tadesse
The objective of this study was to assess traditional, complementary, and alternative medicine (TCAM) utilization pattern among HIV/AIDS patients on antiretroviral therapy at University of Gondar Comprehensive Specialized Hospital. Materials and Methods. Data on sociodemographic profile and clinical and TCAM utilization were collected using a structured, pretested questionnaire from April 01 to May 28, 2014, through interviews with patients. Data on CD4 count, HIV stage, and ART regimen were collected from patient records...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28346249/usefulness-of-68ga-dota-rgd-%C3%AE-v%C3%AE-3-pet-ct-imaging-in-thyroglobulin-elevation-with-negative-iodine-scintigraphy
#14
Rakhee Vatsa, Jaya Shykla, Bhagwant Rai Mittal, Priya Bhusari, Apurva Sood, Rajender Kumar Basher, Anish Bhattacharya
TENIS (thyroglobulin elevation with negative iodine scintigraphy) syndrome in patients with differentiated thyroid carcinoma is not a rare finding. In such patients, F-FDG PET/CT can help in disease evaluation. RGD tripeptide, used for imaging angiogenesis, may also help in disease detection in patients with negative radioiodine whole-body scan. We present 1 such case in whom Ga-RGD tripeptide imaging was helpful in disease detection in the setting of negative radioiodine whole-body scan.
June 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28274219/a-household-survey-of-medicine-storage-practices-in-gondar-town-northwestern-ethiopia
#15
Fitsum Sebsibe Teni, Abdrrahman Shemsu Surur, Assefa Belay, Dawit Wondimsigegn, Dessalegn Asmelashe Gelayee, Zewdneh Shewamene, Befikadu Legesse, Eshetie Melese Birru
BACKGROUND: Household surveys are crucial to get accurate information on how medicines are acquired, and used by consumers, as they provide the best evidence in the area. The objective of this study was to document household medicine storage practices in Gondar town, northwestern Ethiopia. METHODS: A cross-sectional household survey was conducted from April 5 to May 6, 2015. In the study, 809 households were surveyed from four sub-cities in the town selected through multistage sampling with 771 included in the final analysis...
March 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28244466/human-papillomavirus-p16-positive-head-and-neck-cancer-in-india-prevalence-clinical-impact-and-influence-of-tobacco-use
#16
V Murthy, M Swain, T Teni, S Pawar, P Kalkar, A Patil, A Chande, S Ghonge, S G Laskar, T Gupta, A Budrukkar, J Agrawal
BACKGROUND: Limited data are available on the prevalence and prognostic significance of human papillomavirus (HPV) in squamous cell carcinoma of head and neck (SCCHN) in the Indian population. AIM: The present study aimed to determine the prevalence of HPV and p16 in an Indian cohort of SCCHN and assess their correlation and influence of tobacco use on patient outcomes. MATERIALS AND METHODS: The p16 and HPV status of 170 patients of SCCHN treated with curative chemoradiotherapy was determined using immunohistochemistry and polymerase chain reaction, respectively, and further correlated with their demographic characteristics...
July 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28120116/urine-drug-screen-findings-among-ambulatory-oncology-patients-in-a-supportive-care-clinic
#17
Sherri Rauenzahn, Adam Sima, Brian Cassel, Danielle Noreika, Teny Henry Gomez, Lynn Ryan, Carl E Wolf, Luke Legakis, Egidio Del Fabbro
PURPOSE: Professional organizations provide no guidelines regarding assessment and management of opioid abuse risk in cancer. Universal precautions (UP) developed for non-cancer pain, include assessments for aberrant behavior, screening questionnaires, and urine drug screens (UDS). The role of UDS for identifying opioid abuse risk in cancer is uncertain. Our aim is to characterize inappropriate UDS, and identify a potential role for UDS in therapeutic decision-making. METHODS: An observational retrospective chart review of 232 consecutive supportive care clinic patients were seen during the study...
June 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28036235/biomarkers-for-uranium-risk-assessment-for-the-development-of-the-cure-concerted-uranium-research-in-europe-molecular-epidemiological-protocol
#18
REVIEW
Yann Guéguen, Laurence Roy, Sabine Hornhardt, Christophe Badie, Janet Hall, Sarah Baatout, Eileen Pernot, Ladislav Tomasek, Olivier Laurent, Teni Ebrahimian, Chrystelle Ibanez, Stephane Grison, Sylwia Kabacik, Dominique Laurier, Maria Gomolka
Despite substantial experimental and epidemiological research, there is limited knowledge of the uranium-induce health effects after chronic low-dose exposures in humans. Biological markers can objectively characterize pathological processes or environmental responses to uranium and confounding agents. The integration of such biological markers into a molecular epidemiological study would be a useful approach to improve and refine estimations of uranium-induced health risks. To initiate such a study, Concerted Uranium Research in Europe (CURE) was established, and involves biologists, epidemiologists and dosimetrists...
January 2017: Radiation Research
https://www.readbyqxmd.com/read/27970934/management-of-children-s-acute-diarrhea-by-community-pharmacies-in-five-towns-of-ethiopia-simulated-client-case
#19
T B Abebe, T M Abegaz, S A Belachew, B M Gebresilassie, F S Teni, H G Woldie
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27863564/designing-and-developing-pet-based-precision-model-in-thyroid-carcinoma-the-potential-avenues-for-a-personalized-clinical-care
#20
REVIEW
Sandip Basu, Rahul Vithalrao Parghane
This communication enumerates the current uses and potential areas where PET could be clinically utilized for developing "precision medicine" type model in thyroid carcinoma. (1) In routine clinics, PET imaging (with fluorodeoxyglucose [FDG]) is utilized to investigate patients of differentiated thyroid carcinoma (DTC) with high thyroglobulin and negative iodine scintigraphy (TENIS) and in medullary carcinoma thyroid (MCT) when the tumor markers (eg, calcitonin and carcino embryonic antigen [CEA]) are raised postoperatively (PET with FDG,68 Ga-DOTA-NOC/TATE, FDOPA)...
January 2017: PET Clinics
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