Guanxi Xiao, Rosie Kumar, Yutaro Komuro, Jasmine Burguet, Visesha Kakarla, Ida Azizkhanian, Sunil A Sheth, Christopher K Williams, Xinhai R Zhang, Michal Macknicki, Andrew Brumm, Riki Kawaguchi, Phu Mai, Naoki Kaneko, Harry V Vinters, S Thomas Carmichael, Leif A Havton, Charles DeCarli, Jason D Hinman
Cerebral small vessel disease and brain white matter injury are worsened by cardiovascular risk factors including obesity. Molecular pathways in cerebral endothelial cells activated by chronic cerebrovascular risk factors alter cell-cell signaling, blocking endogenous and post-ischemic white matter repair. Using cell-specific translating ribosome affinity purification (RiboTag) in white matter endothelia and oligodendrocyte progenitor cells (OPCs), we identify a coordinated interleukin-chemokine signaling cascade within the oligovascular niche of subcortical white matter that is triggered by diet-induced obesity (DIO)...
December 20, 2022: Cell Reports