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IL-17B

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https://www.readbyqxmd.com/read/29719541/a-reappraisal-on-the-potential-ability-of-human-neutrophils-to-express-and-produce-il-17-family-members-in-vitro-failure-to-reproducibly-detect-it
#1
Nicola Tamassia, Fabio Arruda-Silva, Federica Calzetti, Silvia Lonardi, Sara Gasperini, Elisa Gardiman, Francisco Bianchetto-Aguilera, Luisa Benerini Gatta, Giampiero Girolomoni, Alberto Mantovani, William Vermi, Marco A Cassatella
Neutrophils are known to perform a series of effector functions that are crucial for the innate and adaptive responses, including the synthesis and secretion of a variety of cytokines. In light of the controversial data in the literature, the main objective of this study was to more in-depth reevaluate the capacity of human neutrophils to express and produce cytokines of the IL-17 family in vitro . By reverse transcription quantitative real-time PCR, protein measurement via commercial ELISA, immunohistochemistry (IHC) and immunofluorescence (IF), flow cytometry, immunoblotting, chromatin immunoprecipitation (ChIP), and ChIP-seq experiments, we found that highly pure (>99...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29569854/il-25-axis-is-involved-in-the-pathogenesis-of-human-primary-and-experimental-sj%C3%A3-gren-s-syndrome
#2
Giuliana Guggino, Xiang Lin, Aroldo Rizzo, Fan Xiao, Laura Saieva, Stefania Raimondo, Diana Di Liberto, Giuseppina Candore, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Francesco Dieli, Riccardo Alessandro, Giovanni Triolo, Liwei Lu, Francesco Ciccia
OBJECTIVE: To investigate the role of IL-25/IL-17RB axis in experimental Sjögren's syndrome (ESS) and in patients with primary Sjögren Syndrome (pSS) and pSS-associated lymphoma. METHODS: Expression of IL-25, IL-17RB, IL-17B and TRAF6 was analyzed on minor salivary glands (MSG) from pSS patients and on parotid glands from pSS-associated B cell non-Hodgkin lymphomas (NHL). IL-17RB expression and the frequencies of natural type 2 innate lymphoid cells (nILC2), inflammatory ILC2 (iILC2) and M2-polarized macrophages were assessed by flow cytometry in salivary gland mononuclear cells (SGMC) and peripheral blood mononuclear cells (PBMC)...
March 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29496538/a-positive-feedback-loop-of-il-17b-il-17rb-activates-erk-%C3%AE-catenin-to-promote-lung-cancer-metastasis
#3
Yi-Fang Yang, Yi-Chen Lee, Steven Lo, Yi-Ning Chung, Ya-Ching Hsieh, Wen-Chin Chiu, Shyng-Shiou F Yuan
Inflammation contributes to the development and progression of cancer. Interleukin-17 (IL-17) is an inflammatory cytokine that functions in inflammation and cancer, as well as several other cellular processes. In this study, we investigated the roles and the prognostic value of IL-17 and the IL-17 receptor (IL-17R) in lung cancer. Gene expression microarray analysis followed by Kaplan-Meier survival curve showed that IL-17B was associated with poor patient survival, and IL-17B receptor (IL-17RB) was up-regulated in lung cancer tissue compared with normal tissue...
May 28, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29429072/an-ex-vivo-ruminal-ovine-model-to-study-the-immediate-immune-response-in-the-context-of-bacterial-lipopolysaccharide
#4
Fathi Abouhajer, Saeed El-Ashram, Musafiri Karama, Shujian Huang, Jian-Feng Liu
We have set up an ex vivo ovine ruminal model, which can mimic the multicellular process to explore the early steps in Salmonella typhimurium lipopolysaccharide (LPS) stimulation using RNA-seq technology. Ovine ruminal explants were collected for histological and transcriptional analysis and supernatants collected to quantitate lactate dehydrogenase (LDH) enzymes. A total of 8 and 523 genes were significantly over-expressed between LPS-treated and control tissues at 6 and 12 h, respectively. However, six and seven hundred and thirteen genes were substantially repressed between the aforementioned tissues, correspondingly...
May 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29371916/the-il-17b-il-17-receptor-b-pathway-promotes-resistance-to-paclitaxel-in-breast-tumors-through-activation-of-the-erk1-2-pathway
#5
Emilie Laprevotte, Stéphanie Cochaud, Stanislas du Manoir, Marion Lapierre, Cécile Dejou, Marion Philippe, Jérome Giustiniani, Kathryn A Frewer, Andrew J Sanders, Wen G Jiang, Henri-Alexandre Michaud, Pierre-Emmanuel Colombo, Armand Bensussan, Gilles Alberici, Jérémy Bastid, Jean-François Eliaou, Nathalie Bonnefoy
Interleukin 17B (IL-17B) is a pro-inflammatory cytokine that belongs to the IL-17 cytokines family and binds to IL-17 receptor B (IL-17RB). Here we found that high expression of IL-17B and IL-17RB is associated with poor prognosis in patients with breast cancer and that IL-17B expression upregulation is specifically associated with poorer survival in patients with basal-like breast cancer. We thus focused on IL-17B role in breast cancer by using luminal and triple negative (TN)/basal-like tumor cell lines. We found that IL-17B induces resistance to conventional chemotherapeutic agents...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205464/interleukin-17-family-cytokines-in-protective-immunity-against-infections-role-of-hematopoietic-cell-derived-and-non-hematopoietic-cell-derived-interleukin-17s
#6
REVIEW
Goro Matsuzaki, Masayuki Umemura
Interleukin-17 family cytokines, consisting of six members, participate in immune response in infections and autoimmune and inflammatory diseases. The prototype cytokine of the family, IL-17A, was originally identified from CD4+ T cells which are now termed Th17 cells. Later, IL-17A-producing cells were expanded to include various hematopoietic cells, namely CD8+ T cells (Tc17), invariant NKT cells, γδ T cells, non-T non-B lymphocytes (termed type 3 innate lymphoid cells) and neutrophils. Some IL-17 family cytokines other than IL-17A are also expressed by CD4+ T cells: IL-17E by Th2 cells and IL-17F by Th17 cells...
January 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/28715683/il-17rb-enhances-thyroid-cancer-cell-invasion-and-metastasis-via-erk1-2-pathway-mediated-mmp-9-expression
#7
Lei Ren, Yapei Xu, Cong Liu, Shoujun Wang, Guijun Qin
IL-17RB, a member of the IL-17 receptor family that can be activated by IL-17B, has been proved to be involved in inflammatory diseases and cancers. However, the function of IL-17RB in thyroid cancer is still unknown. In this study, IL-17RB expression in thyroid cancer cell lines and tissues was examined by real-time PCR and western blot. The effects of IL-17RB on cell invasion and migration were determined by in vitro invasion and migration assays, while the effects of IL-17RB on cell metastasis were analyzed by in vivo experiments...
October 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28704706/il-17b-a-new-area-of-study-in-the-il-17-family
#8
REVIEW
Qingli Bie, Chengqiang Jin, Bin Zhang, Haixin Dong
The interleukin (IL)-17 superfamily, a relatively new family of cytokines, consists of six ligands (from IL-17A to IL-17F), which bind to five receptor subtypes (from IL-17RA to IL-17RE) and induce downstream signaling. IL-17A, a prototype member of this family, has been reported to be involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies. Unlike IL-17A, which is mainly produced by T helper 17 cells, IL-17B is widely expressed in various tissues. Recently, the biological function of IL-17B in diseases, particularly tumors, has attracted the attention of researchers...
October 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28624391/efficacy-of-melatonin-il-25-and-siil-17b-in-tumorigenesis-associated-properties-of-breast-cancer-cell-lines
#9
Gabriela Bottaro Gelaleti, Thaiz Ferraz Borin, Larissa Bazela Maschio-Signorini, Marina Gobbe Moschetta, Bruna Victorasso Jardim-Perassi, Guilherme Berto Calvinho, Mariana Castilho Facchini, Alicia M Viloria-Petit, Debora Aparecida Pires de Campos Zuccari
Mammary tumorigenesis can be modulated by melatonin, which has oncostatic action mediated by multiple mechanisms, including the inhibition of the activity of transcription factors such as NF-κB and modulation of interleukins (ILs) expression. IL-25 is an active cytokine that induces apoptosis in tumor cells due to differential expression of its receptor (IL-17RB). IL-17B competes with IL-25 for binding to IL-17RB in tumor cells, promoting tumorigenesis. This study purpose is to address the possibility of engaging IL-25/IL-17RB signaling to enhance the effect of melatonin on breast cancer cells...
August 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28416436/molecular-cloning-of-chicken-interleukin-17b-which-induces-proinflammatory-cytokines-through-activation-of-the-nf-%C3%AE%C2%BAb-signaling-pathway
#10
Cong Thanh Hoang, Yeojin Hong, Anh Duc Truong, Janggeun Lee, Kyungbaek Lee, Yeong Ho Hong
Interleukin (IL)-17B is a little known member of the IL-17 cytokine family, which plays an important role in immunity by regulating the expression of proinflammatory cytokines. In this study, we determined the coding sequence and biological functions of a novel chicken IL-17B (chIL-17B). The full-length chIL-17B coding sequence includes 567 nucleotides encoding 188 amino acids, which was identified in small intestinal epithelial cells. The chIL-17B protein shares 96.48% amino acid sequence identity with turkey, 92...
September 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28414206/wenshen-zhuanggu-formula-effectively-suppresses-breast-cancer-bone-metastases-in-a-mouse-xenograft-model
#11
Jia-Jia Li, Wei-Ling Chen, Jian-Yi Wang, Qian-Wen Hu, Zhen-Ping Sun, Shuai Zhang, Sheng Liu, Xiang-Hui Han
Wenshen Zhuanggu formula (WSZG) is a traditional Chinese medicine used as an adjuvant for the prevention of bone metastases in breast cancer patients. In this study we investigated the efficacy of WSZG in preventing bone metastases and the potential mechanisms in a mouse xenograft model of breast cancer bone metastases. This model was established by injection of human MDA-MB-231BO-Luc breast cancer cells alone or a mixture of the cancer cells with bone marrow-derived mesenchymal stem cells (BMSCs) into left ventricle of the heart in female nude mice...
October 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28322030/melatonin-and-il-25-modulate-apoptosis-and-angiogenesis-mediators-in-metastatic-cf-41-and-non-metastatic-cmt-u229-canine-mammary-tumour-cells
#12
G B Gelaleti, T F Borin, L B Maschio-Signorini, M G Moschetta, E Hellmén, A M Viloria-Petit, D A P C Zuccari
BACKGROUND: Melatonin has oncostatic actions and IL-25 is active in inflammatory processes that induce apoptosis in tumor cells AIM: The aim of this study was to evaluate melatonin and IL-25 in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumor cells cultured as monolayers and tridimensional structures. MATERIALS AND METHODS: The cells were treated with melatonin, IL-25 and IL-17B silencing gene and performed cell viability, gene and protein expression of caspase-3 and VEGFA (Vascular endothelial growth factor A) and an apoptosis membrane protein array...
March 20, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28145881/il-17b-activated-mesenchymal-stem-cells-enhance-proliferation-and-migration-of-gastric-cancer-cells
#13
Qingli Bie, Bin Zhang, Caixia Sun, Xiaoyun Ji, Prince Amoah Barnie, Chen Qi, Jingjing Peng, Danyi Zhang, Dong Zheng, Zhaoliang Su, Shengjun Wang, Huaxi Xu
Mesenchymal stem cells are important cells in tumor microenvironment. We have previously demonstrated that IL-17B/IL-17RB signal promoted progression of gastric cancer. In this study, we further explored the effect of IL-17B on mesenchymal stem cells in tumor microenvironment and its impact on the tumor progression. The results showed that IL-17B induced the expression of stemness-related genes Nanog, Sox2, and Oct4 in mesenchymal stem cells and enhanced its tumor-promoting effect. The supernatant from cultured mesenchymal stem cells after treating with exogenous rIL-17B promoted the proliferation and migration of MGC-803, therefor suggesting that rIL-17B might promote mesenchymal stem cells to produce soluble factors...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28039016/il-17b-is-elevated-in-patients-with-pneumonia-and-mediates-il-8-production-in-bronchial-epithelial-cells
#14
Jie Zhou, Lei Ren, Dapeng Chen, Xue Lin, Shifeng Huang, Yibing Yin, Ju Cao
The role of IL-17B in regulating pulmonary immunity and inflammation is unknown. In this study, we found that IL-17B concentrations were significantly elevated in adult and paediatric patients with community-acquired pneumonia relative to their corresponding healthy adult and paediatric controls. The increased concentrations of IL-17B significantly and positively correlated with chemokine IL-8 concentrations in clinical pneumonia. In vitro studies demonstrated that IL-17B could induce gene and protein expression of IL-8 in human bronchial epithelial cells, but not lung fibroblasts, which was regulated by the activation of Akt, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and nuclear factor-kappaB (NF-κB) signaling pathways...
February 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27594509/a-heterodimeric-cytokine-consisting-of-il-17a-and-il-17f-promotes-migration-and-capillary-like-tube-formation-of-human-vascular-endothelial-cells
#15
Muneo Numasaki, Hiroki Tsukamoto, Yoshihisa Tomioka, Yasuhiko Nishioka, Takashi Ohrui
The interleukin (IL)-17 family, consisting of six homodimeric cytokines IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, mediates a variety of biological activities including regulation of chemokine secretion and angiogenesis. Among the IL-17 family members, IL-17A and IL-17E/IL-25 are angiogenesis stimulators, while IL-17B and IL-17F are angiogenesis inhibitors. Recently, IL-17A/F heterodimer, comprised of the IL-17A and IL-17F subunits, was found as another member of the IL-17 cytokine family. However, to date, it has been unknown whether IL-17A/F has biological actions to affect the angiogenesis-related vascular endothelial functions...
September 2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27591988/il17a-and-il17f-gene-polymorphism-association-with-psoriasis-risk-and-response-to-treatment-in-a-polish-population
#16
Monika Białecka, Roksana Ostasz, Mateusz Kurzawski, Adam Klimowicz, Honorata Fabiańczyk, Piotr Bojko, Violetta Dziedziejko, Krzysztof Safranow, Anna Machoy-Mokrzyńska, Marek Droździk
BACKGROUND: Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development and treatment outcome. The IL-17 family consists of 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), of which IL-17A and IL-17F mediate similar biological effects. OBJECTIVES: The aim of this study was to evaluate an association between the IL17A (-197G>A; rs2275913) and IL17F (rs763780: T>C; rs11465553: G>A; rs2397084: T>C) polymorphisms with psoriasis susceptibility as well as response to topical and combined topical with narrow-band ultraviolet B (NB-UVB) therapy in a Polish population...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27589729/targeting-the-tumor-microenvironment-the-protumor-effects-of-il-17-related-to-cancer-type
#17
REVIEW
Joseph Fabre, Jerome Giustiniani, Christian Garbar, Frank Antonicelli, Yacine Merrouche, Armand Bensussan, Martine Bagot, Reem Al-Dacak
The inflammatory process contributes to immune tolerance as well as to tumor progression and metastasis. By releasing extracellular signals, cancerous cells constantly shape their surrounding microenvironment through their interactions with infiltrating immune cells, stromal cells and components of extracellular matrix. Recently, the pro-inflammatory interleukin 17 (IL-17)-producing T helper lymphocytes, the Th17 cells, and the IL-17/IL-17 receptor (IL-17R) axis gained special attention. The IL-17 family comprises at least six members, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F...
August 30, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27566830/il-17-superfamily-cytokines-modulate-normal-germinal-center-b-cell-migration
#18
REVIEW
Elisa Ferretti, Maurilio Ponzoni, Claudio Doglioni, Vito Pistoia
The germinal center (GC) is a dynamic structure formed by proliferating B cells in the follicles of secondary lymphoid organs during T cell-dependent antibody responses to exogenous antigens. GC is composed by a dark zone, enriched in proliferating centroblasts (CBs), and a light zone where CBs migrate and transform into centrocytes (CCs), a minority of which is selected to survive, undergoes Ig class-switch recombination, and differentiates into memory B cells or long-lived plasma cells. CBs express CXCR4 and are attracted to the dark zone by stromal cell-derived CXCL12, whereas CCs express CXCR5 and are recruited to the light zone along a gradient of CXCL13 produced by follicular dendritic cells (FDCs)...
November 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27146881/non-tumor-tissue-derived-interleukin-17b-activates-il-17rb-akt-%C3%AE-catenin-pathway-to-enhance-the-stemness-of-gastric-cancer
#19
Qingli Bie, Caixia Sun, Aihua Gong, Chunye Li, Zhaoliang Su, Dong Zheng, Xiaoyun Ji, Yumin Wu, Qi Guo, Shengjun Wang, Huaxi Xu
Inflammation is a critical component involved in tumor progression. Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has been associated with the progression of cancers. However, the role of IL-17B/IL-17RB (IL-17 receptor B) signaling to stemness of gastric cancer remains unknown. Here, we confirmed that the expression of IL-17RB in gastric cancer tissues was significantly increased, that overexpression was associated with poor prognosis of gastric cancer patients, and that overexpression was positively correlated with some stemness markers...
May 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26721231/characterization-of-six-il-17-family-genes-in-miiuy-croaker-and-evolution-analysis-of-vertebrate-il-17-family
#20
Qiong Yang, Yuena Sun, Xiurong Su, Taiwu Li, Tianjun Xu
Interleukin-17 (IL-17) family is a cytokine family which is one of the major signaling molecules family involved in immunity. Six member of IL-17 family cytokines (IL-17A-F) were found in mammals. In fish, all IL-17 family genes except IL-17B and IL-17E have been isolated and identified. Besides, IL-17N is uniquely found from teleosts. IL-17 family genes are widely studied in mammals, but have not been widely reported in lower vertebrates. In this study, we identify six IL-17 family genes (IL-17A/F1-3, IL-17C, IL-17D, IL-17N) from miiuy croaker, using LPS and poly (I:C) to infect miiuy croaker in order to analyze the expression response to bacteria and virus and expression in normal tissues...
February 2016: Fish & Shellfish Immunology
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