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https://www.readbyqxmd.com/read/27594509/a-heterodimeric-cytokine-consisting-of-il-17a-and-il-17f-promotes-migration-and-capillary-like-tube-formation-of-human-vascular-endothelial-cells
#1
Muneo Numasaki, Hiroki Tsukamoto, Yoshihisa Tomioka, Yasuhiko Nishioka, Takashi Ohrui
The interleukin (IL)-17 family, consisting of six homodimeric cytokines IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, mediates a variety of biological activities including regulation of chemokine secretion and angiogenesis. Among the IL-17 family members, IL-17A and IL-17E/IL-25 are angiogenesis stimulators, while IL-17B and IL-17F are angiogenesis inhibitors. Recently, IL-17A/F heterodimer, comprised of the IL-17A and IL-17F subunits, was found as another member of the IL-17 cytokine family. However, to date, it has been unknown whether IL-17A/F has biological actions to affect the angiogenesis-related vascular endothelial functions...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27591988/il17a-and-il17f-gene-polymorphism-association-with-psoriasis-risk-and-response-to-treatment-in-a-polish-population
#2
Monika Białecka, Roksana Ostasz, Mateusz Kurzawski, Adam Klimowicz, Honorata Fabiańczyk, Piotr Bojko, Violetta Dziedziejko, Krzysztof Safranow, Anna Machoy-Mokrzyńska, Marek Droździk
BACKGROUND: Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development and treatment outcome. The IL-17 family consists of 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), of which IL-17A and IL-17F mediate similar biological effects. OBJECTIVES: The aim of this study was to evaluate an association between the IL17A (-197G>A; rs2275913) and IL17F (rs763780: T>C; rs11465553: G>A; rs2397084: T>C) polymorphisms with psoriasis susceptibility as well as response to topical and combined topical with narrow-band ultraviolet B (NB-UVB) therapy in a Polish population...
September 3, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27589729/targeting-the-tumor-microenvironment-the-protumor-effects-of-il-17-related-to-cancer-type
#3
REVIEW
Joseph Fabre, Jerome Giustiniani, Christian Garbar, Frank Antonicelli, Yacine Merrouche, Armand Bensussan, Martine Bagot, Reem Al-Dacak
The inflammatory process contributes to immune tolerance as well as to tumor progression and metastasis. By releasing extracellular signals, cancerous cells constantly shape their surrounding microenvironment through their interactions with infiltrating immune cells, stromal cells and components of extracellular matrix. Recently, the pro-inflammatory interleukin 17 (IL-17)-producing T helper lymphocytes, the Th17 cells, and the IL-17/IL-17 receptor (IL-17R) axis gained special attention. The IL-17 family comprises at least six members, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27566830/il-17-superfamily-cytokines-modulate-normal-germinal-center-b-cell-migration
#4
Elisa Ferretti, Maurilio Ponzoni, Claudio Doglioni, Vito Pistoia
The germinal center (GC) is a dynamic structure formed by proliferating B cells in the follicles of secondary lymphoid organs during T cell-dependent antibody responses to exogenous antigens. GC is composed by a dark zone, enriched in proliferating centroblasts (CBs), and a light zone where CBs migrate and transform into centrocytes (CCs), a minority of which is selected to survive, undergoes Ig class-switch recombination, and differentiates into memory B cells or long-lived plasma cells. CBs express CXCR4 and are attracted to the dark zone by stromal cell-derived CXCL12, whereas CCs express CXCR5 and are recruited to the light zone along a gradient of CXCL13 produced by follicular dendritic cells (FDCs)...
August 26, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27146881/non-tumor-tissue-derived-interleukin-17b-activates-il-17rb-akt-%C3%AE-catenin-pathway-to-enhance-the-stemness-of-gastric-cancer
#5
Qingli Bie, Caixia Sun, Aihua Gong, Chunye Li, Zhaoliang Su, Dong Zheng, Xiaoyun Ji, Yumin Wu, Qi Guo, Shengjun Wang, Huaxi Xu
Inflammation is a critical component involved in tumor progression. Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has been associated with the progression of cancers. However, the role of IL-17B/IL-17RB (IL-17 receptor B) signaling to stemness of gastric cancer remains unknown. Here, we confirmed that the expression of IL-17RB in gastric cancer tissues was significantly increased, that overexpression was associated with poor prognosis of gastric cancer patients, and that overexpression was positively correlated with some stemness markers...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26721231/characterization-of-six-il-17-family-genes-in-miiuy-croaker-and-evolution-analysis-of-vertebrate-il-17-family
#6
Qiong Yang, Yuena Sun, Xiurong Su, Taiwu Li, Tianjun Xu
Interleukin-17 (IL-17) family is a cytokine family which is one of the major signaling molecules family involved in immunity. Six member of IL-17 family cytokines (IL-17A-F) were found in mammals. In fish, all IL-17 family genes except IL-17B and IL-17E have been isolated and identified. Besides, IL-17N is uniquely found from teleosts. IL-17 family genes are widely studied in mammals, but have not been widely reported in lower vertebrates. In this study, we identify six IL-17 family genes (IL-17A/F1-3, IL-17C, IL-17D, IL-17N) from miiuy croaker, using LPS and poly (I:C) to infect miiuy croaker in order to analyze the expression response to bacteria and virus and expression in normal tissues...
February 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/26628969/individualized-treatment-strategies-and-predictors-of-virological-response-for-chronic-hepatitis-c-a-multicenter-prospective-study-from-china
#7
Yue-Min Nan, Yu-Guo Zhang, Huan-Wei Zheng, Chun-Mian An, You-Sheng Li, Ying Zhang, Dian-Xing Sun, Cang-You Li, Qiang Li, Li-Xin Tong, Ling-Bo Kong, Su-Xian Zhao, Rong-Qi Wang, Ping Meng, Shan-Shan Su, Huan He, Xue-Min Niu
Combination therapy comprising pegylated interferon-alpha (PegIFNα) and ribavirin (RBV) has been the standard of care for the chronic hepatitis C patients for more than a decade. Recently, direct antiviral agents show better efficacy, tolerance, and shorter treatment duration. However, the prohibitive costs of the regimens limit their use in developing countries where most of the HCV infection exists. Optimizing the treatment and understanding the host- and virus-factors associated with viral clearance were necessary for individualizing therapy to maximize sustained virologic response...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26491201/characterization-of-lamprey-il-17-family-members-and-their-receptors
#8
Qifeng Han, Sabyasachi Das, Masayuki Hirano, Stephen J Holland, Nathanael McCurley, Peng Guo, Charles S Rosenberg, Thomas Boehm, Max D Cooper
IL-17 is an ancient cytokine implicated in a variety of immune defense reactions. We identified five members of the sea lamprey IL-17 family (IL-17D.1, IL-17D.2, IL-17E, IL-17B, and IL-17C) and six IL-17R genes (IL-17RA.1, IL-17RA.2, IL-17RA.3, IL-17RF, IL-17RE/RC, and IL-17RD), determined their relationship with mammalian orthologs, and examined their expression patterns and potential interactions to explore their roles in innate and adaptive immunity. The most highly expressed IL-17 family member is IL-17D...
December 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26490738/f4-etec-infection-and-oral-immunization-with-f4-fimbriae-elicits-an-il-17-dominated-immune-response
#9
Yu Luo, Ut Van Nguyen, Pedro Y de la Fe Rodriguez, Bert Devriendt, Eric Cox
Enterotoxigenic Escherichia coli (ETEC) are an important cause of post-weaning diarrhea (PWD) in piglets. Porcine-specific ETEC strains possess different fimbrial subtypes of which F4 fimbriae are the most frequently associated with ETEC-induced diarrhea in piglets. These F4 fimbriae are potent oral immunogens that induce protective F4-specific IgA antibody secreting cells at intestinal tissues. Recently, T-helper 17 (Th17) cells have been implicated in the protection of the host against extracellular pathogens...
2015: Veterinary Research
https://www.readbyqxmd.com/read/26304506/distinctive-expression-pattern-of-interleukin-17-cytokine-family-members-in-colorectal-cancer
#10
Ahmed Al-Samadi, Shirin Moossavi, Abdelhakim Salem, Masoud Sotoudeh, Sarianna M Tuovinen, Yrjö T Konttinen, Tuula Salo, Faraz Bishehsari
Colorectal cancer (CRC) is one of the most common cancers in both genders. Even though interleukin (IL)-17A was shown to play an important role in intestinal tumourigenesis and CRC, other IL-17 family members were not studied well. We therefore studied the expression of IL-17 cytokine family members in CRC. Ten healthy colons and ten CRC mucosa were immunostained for IL-17B, IL-17C, IL-17E, and IL-17F, and their receptors IL-17RA, IL-17RB, and IL-17RC. Double immunofluorescence staining of the CRC mucosa was done for IL-17B with markers of neutrophils, endothelial cells, macrophages, T cells, mast cells, or fibroblasts...
February 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26095319/interaction-of-thymic-stromal-lymphopoietin-il-33-and-their-receptors-in-epithelial-cells-in-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#11
B Liao, P-P Cao, M Zeng, Z Zhen, H Wang, Y-N Zhang, C-Y Hu, J Ma, Z-Y Li, J Song, J-X Liu, L-Y Peng, Y Liu, Q Ning, Z Liu
BACKGROUND: Thymic stromal lymphopoietin (TSLP), IL-25, and IL-33 system contribute to the initiation and development of Th2 responses. This study aimed to explore the involvement of TSLP, IL-25, IL-33, and their receptors in type 2 T-helper (Th) responses in chronic rhinosinusitis with nasal polyps (CRSwNPs) and their cross-regulation in human nasal epithelial cells (HNECs). METHODS: Immunohistochemistry, quantitative RT-PCR, ELISA, Bio-Plex assay, and flow cytometry were used to detect the expression of TSLP/common γ-like TSLP receptor (TSLPR)/IL-7 receptor α (IL-7Rα), IL-25/IL-17B receptor (IL-17RB), and IL-33/membrane-bound ST2 (ST2L)/soluble ST2 (sST2) in sinonasal mucosa and HNECs...
September 2015: Allergy
https://www.readbyqxmd.com/read/25901193/identification-and-characterization-of-cd4-at2-t-lymphocyte-population-in-human-thoracic-aortic-aneurysm
#12
Chenxi Wang, Ting Wu, Xiaojuan Hu, Ritai Huang, Feng Lian, Weijun Wang, Yuan Feng, Bo Xie, Zhenlei Hu, Xinming Zhai, Jidong Liu, Jianmin Gu, Yao Chen, Jun Li, Song Xue
Thoracic aortic aneurysm (TAA) is progressive fatal aortic pathological dilation. However, the underlying molecular mechanisms are still largely unknown. Evidences suggest that endothelial cells and renin-angiotensin system may participate in the pathogenesis of TAA. This study aimed to investigate whether angiotensin II type 2 receptor (AT2) positive cells are involved in TAA formation. The mRNA level of AT2 is dramatically elevated in TAA compared with in controls. CD4(+)AT2(+) cells increased in both aortic wall and circulation of TAA patients...
2015: American Journal of Translational Research
https://www.readbyqxmd.com/read/25888259/interleukin-17b-antagonizes-interleukin-25-mediated-mucosal-inflammation
#13
Joseph M Reynolds, Young-Hee Lee, Yun Shi, Xiaohu Wang, Pornpimon Angkasekwinai, Kalyan C Nallaparaju, Stephanie Flaherty, Seon Hee Chang, Hiroshi Watarai, Chen Dong
The interleukin-17 (IL-17) family of cytokines has emerged as a critical player in inflammatory diseases. Among them, IL-25 has been shown to be important in allergic inflammation and protection against parasitic infection. Here we have demonstrated that IL-17B, a poorly understood cytokine, functions to inhibit IL-25-driven inflammation. IL-17B and IL-25, both binding to the interleukin-17 receptor B (IL-17RB), were upregulated in their expression after acute colonic inflammation. Individual inhibition of these cytokines revealed opposing functions in colon inflammation: IL-25 was pathogenic but IL-17B was protective...
April 21, 2015: Immunity
https://www.readbyqxmd.com/read/25732306/targeting-il-17b-il-17rb-signaling-with-an-anti-il-17rb-antibody-blocks-pancreatic-cancer-metastasis-by-silencing-multiple-chemokines
#14
Heng-Hsiung Wu, Wendy W Hwang-Verslues, Wen-Hsin Lee, Chun-Kai Huang, Pei-Chi Wei, Chia-Lin Chen, Jin-Yuh Shew, Eva Y-H P Lee, Yung-Ming Jeng, Yu-Wen Tien, Che Ma, Wen-Hwa Lee
Pancreatic cancer has an extremely high mortality rate due to its aggressive metastatic nature. Resolving the underlying mechanisms will be crucial for treatment. Here, we found that overexpression of IL-17B receptor (IL-17RB) strongly correlated with postoperative metastasis and inversely correlated with progression-free survival in pancreatic cancer patients. Consistently, results from ex vivo experiments further validated that IL-17RB and its ligand, IL-17B, plays an essential role in pancreatic cancer metastasis and malignancy...
March 9, 2015: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/25554638/anti-metastatic-effect-and-mechanisms-of-wenshen-zhuanggu-formula-in-human-breast-cancer-cells
#15
Xiang-hui Han, Chun-li Wang, Yan Xie, Jiang Ma, Xiao-hui Zhang, Qian-wen Hu, Ge Lin, Sheng Liu, Jin-gen Lu
ETHNOPHARMACOLOGICAL RELEVANCE: Wenshen Zhuanggu Formula (WSZG), a traditional Chinese medicine (TCM) empirical prescription, has been used to treat the patients with breast cancer bone metastasis as an adjuvant in clinical practice. To explore the anti-metastatic activity and potential mechanisms of WSZG-containing serum (WSZG-CS) on highly bone-metastatic human breast cancer MDA-MB-231BO cells. MATERIALS AND METHODS: MDA-MB-231BO cells were cultured alone or co-cultured with bone marrow-derived mesenchymal stem cells (BMSCs)...
March 13, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25369802/clinical-associations-between-il-17-family-cytokines-and-periodontitis-and-potential-differential-roles-for-il-17a-and-il-17e-in-periodontal-immunity
#16
Raja Azman Awang, Raja Azman, David F Lappin, Alexandrea MacPherson, Marcello Riggio, Douglas Robertson, Penny Hodge, Gordon Ramage, Shauna Culshaw, Philip M Preshaw, John Taylor, Christopher Nile
OBJECTIVE: IL-17A is implicated in periodontitis pathogenesis. The roles of IL-17B-IL-17F and IL-17A/F are unknown. This study aimed to determine clinical associations between IL-17 family cytokines and periodontitis and to investigate the biological roles of IL-17A and IL-17E using in vitro model systems. MATERIALS AND METHODS: Samples from 97 patients with periodontitis and 77 healthy volunteers were used in the study. Serum, saliva and gingival crevicular fluid (GCF) levels of IL-17 family cytokines were measured by ELISA...
December 2014: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/25254011/interleukin-17-in-human-inflammatory-diseases
#17
REVIEW
Arezoo Gowhari Shabgah, Ebrahim Fattahi, Fatemeh Zare Shahneh
Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F, tumor necrosis factor (TNF)-α, IL-6, IL-21, IL-22 and IL-23. Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The associated receptors for the IL-17 family identified are IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. This review introduces the roles of IL-17 and Th17 cells in human autoimmune diseases. Studies have shown that T cells with inflammatory effects on epithelial, endothelial and fibroblast cells express IL-17...
August 2014: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/24056520/neutrophils-produce-interleukin-17b-in-rheumatoid-synovial-tissue
#18
COMPARATIVE STUDY
Vesa-Petteri Kouri, Juri Olkkonen, Mari Ainola, Tian-Fang Li, Lena Björkman, Yrjö T Konttinen, Jami Mandelin
OBJECTIVE: T helper 17 (Th17) and mast cells produce IL-17A in RA and critically contribute to the pathogenesis of RA. However, the complete IL-17 cytokine profile in RA is unknown. The aim of the study was to systematically study the expression of IL-17 family cytokines in RA. METHODS: The expression of all IL-17 cytokines in RA synovium and pannus as well as in the synovium of OA was determined using quantitative RT-PCR (qRT-PCR). IL-17A and IL-17B were immunostained...
January 2014: Rheumatology
https://www.readbyqxmd.com/read/23851503/autocrine-paracrine-mechanism-of-interleukin-17b-receptor-promotes-breast-tumorigenesis-through-nf-%C3%AE%C2%BAb-mediated-antiapoptotic-pathway
#19
C-K Huang, C-Y Yang, Y-M Jeng, C-L Chen, H-H Wu, Y-C Chang, C Ma, W-H Kuo, K-J Chang, J-Y Shew, W-H Lee
Gain of function of membrane receptor was a good strategy exploited by cancer cells to benefit own growth and survival. Overexpression of HER2 has been found to serve as a target for developing trastuzumab to treat 20-25% of breast cancer. However, little or none of the other membrane receptor was found to be useful as a potential target for breast cancer treatment since then. Here, we showed that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promoted tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells...
June 5, 2014: Oncogene
https://www.readbyqxmd.com/read/23775092/maximum-likelihood-approaches-reveal-signatures-of-positive-selection-in-il-genes-in-mammals
#20
Fabiana Neves, Joana Abrantes, John W Steinke, Pedro J Esteves
ILs are part of the immune system and are involved in multiple biological activities. ILs have been shown to evolve under positive selection; however, little information exists regarding which codons are specifically selected. By using different codon-based maximum-likelihood (ML) approaches, signatures of positive selection in mammalian ILs were searched for. Sequences of 46 ILs were retrieved from publicly available databases of mammalian genomes to detect signatures of positive selection in individual codons...
February 2014: Innate Immunity
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