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https://www.readbyqxmd.com/read/29662779/finite-element-analysis-of-biomechanical-effects-of-total-ankle-arthroplasty-on-the-foot
#1
Yan Wang, Zengyong Li, Duo Wai-Chi Wong, Cheng-Kung Cheng, Ming Zhang
Background: Total ankle arthroplasty is gaining popularity as an alternation to ankle arthrodesis for end-stage ankle arthritis. Owing to the complex anatomical characteristics of the ankle joint, total ankle arthroplasty has higher failure rates. Biomechanical exploration of the effects of total ankle arthroplasty on the foot and ankle is imperative for the precaution of postoperative complications. The objectives of this study are (1) to investigate the biomechanical differences of the foot and ankle between the foot with total ankle arthroplasty and the intact foot and (2) to investigate the performance of the three-component ankle prosthesis...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29656142/management-of-foot-ankle-osteoarthritis-by-australian-general-practitioners-an-analysis-of-national-patient-encounter-records
#2
Kade L Paterson, Christopher Harrison, Helena Britt, Rana S Hinman, Kim L Bennell
OBJECTIVE: To document the management of foot/ankle osteoarthritis/arthritis (OA) by general practitioners (GP) in Australia. DESIGN: We analysed data from the Bettering the Evaluation and Care of Health Program April 2010-March 2016 inclusive. Patient and GP encounter characteristics were extracted. Data were classified by the International Classification of Primary Care, Version 2, and summarised using descriptive statistics and 95% confidence intervals (95% CIs) around point estimates...
April 12, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29655702/4-2-4-chlorophenyl-1-4-chlorophenyl-amino-ethyl-benzene-1-3-diol-is-a-potential-agent-for-gout-therapy-as-a-dual-inhibitor-of-xod-and-nlrp3
#3
Mengze Zhou, Suning Li, Ling Song, Qinghua Hu, Wentao Liu
BACKGOUND: Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Both anti-hyperuricemia and anti-inflammation could be gout therapeutic strategies, whereas ideal drugs for gout treatment are deficient. PURPOSE: 4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol (CBED) was obtained from a cluster of deoxybenzoins derivatives synthesized by our research group with potent anti-hyperuricemic and anti-inflammatory activities, which was expected to be a dual inhibitor of xanthine oxidase (XOD) and NOD-like receptor protein 3 (NLRP3)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29652187/blood-transfusion-during-total-ankle-arthroplasty-is-associated-with-increased-in-hospital-complications-and-costs
#4
Michael A Ewing, Samuel R Huntley, Dustin K Baker, Kenneth S Smith, Parke W Hudson, Gerald McGwin, Brent A Ponce, Michael D Johnson
INTRODUCTION: Total ankle arthroplasty (TAA) is an increasingly used, effective treatment for end-stage ankle arthritis. Although numerous studies have associated blood transfusion with complications following hip and knee arthroplasty, its effects following TAA are largely unknown. This study uses data from a large, nationally representative database to estimate the association between blood transfusion and inpatient complications and hospital costs following TAA. METHODS: Using the Nationwide Inpatient Sample (NIS) database from 2004 to 2014, 25 412 patients who underwent TAA were identified, with 286 (1...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29619844/comparison-of-screws-to-plate-and-screw-constructs-for-midfoot-arthrodesis
#5
Jamal Ahmad, Mary-Katherine Lynch, Mitchell Maltenfort
BACKGROUND: We performed a prospective comparison of screws versus plate-and-screws for midfoot arthrodesis. MATERIALS: Between 2010 and 2015, a total of 50 patients with midfoot arthritis received screws or plate-and-screws for their midfoot arthrodesis. Function and pain were graded with the Foot and Ankle Ability Measures (FAAM) and visual analog scale (VAS), respectively. Data regarding arthrodesis healing and complications were recorded. RESULTS: Twenty-five patients received screws for fusion, where 21 achieved full arthrodesis healing by 6 months from surgery...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29616452/flavonoid-quercetin-methotrexate-combination-inhibits-inflammatory-mediators-and-matrix-metalloproteinase-expression-providing-protection-to-joints-in-collagen-induced-arthritis
#6
Nagaraja Haleagrahara, Kelly Hodgson, Socorro Miranda-Hernandez, Samuel Hughes, Anupama Bangra Kulur, Ketheesan Natkunum
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovial tissues in joints, leading to progressive destruction of cartilage and joints. The disease-modifying anti-rheumatic drugs currently in use have side-effects. Thus, there is an urgent need for safe anti-inflammatory therapies for RA. This study aimed to evaluate the therapeutic effect of the flavonoid quercetin on arthritis in mice immunized with type II collagen (CII). An arthritis model was established in C57/BL6 mice by intradermal administration of chicken CII mixed with Freund's complete adjuvant...
April 3, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29609637/primary-total-knee-arthroplasty-using-constrained-condylar-knee-design-for-severe-deformity-and-stiffness-of-knee-secondary-to-post-traumatic-arthritis
#7
Saroj Rai, Xianzhe Liu, Xiaobo Feng, Bimal Rai, Nira Tamang, Jing Wang, Shunan Ye, Shuhua Yang
BACKGROUND: Key to a successful outcome of total knee arthroplasty (TKA) is to attain optimum alignment, adequate balance, and deformity correction. In primary TKA, this can be achieved efficiently by posterior stabilized (PS) design with or without the sub-periosteal release. However, certain circumstances such as post-traumatic arthritis are often associated with severe deformities with a significant bone defect, stiffness, and instability. Such deformities are extremely difficult to balance with soft tissue release only and require additionally constrained prostheses even in primary TKA...
April 2, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29605554/ankle-arthritis-combined-with-chronic-instability-of-the-syndesmosis-after-ankle-fracture-with-syndesmotic-injury-a-case-report
#8
Bi O Jeong, Jong Hun Baek, Wook Jae Song
Syndesmotic injuries associated with ankle fractures are commonly treated with reduction and fixation using a transfixing screw. On rare occasions, however, progression to chronic instability of the syndesmosis is observed. Several surgical techniques have been applied in such cases but usually without a report on the results. We report a case of chronic syndesmotic instability and ankle joint osteoarthritis after ankle fracture-dislocation in a 21-year-old male patient who underwent distal tibiofibular arthrodesis...
March 28, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29599513/akkermansia-muciniphila-is-permissive-to-arthritis-in-the-k-bxn-mouse-model-of-arthritis
#9
Matthew L Stoll, M Kathy Pierce, Jordan A Watkins, Mingce Zhang, Pamela F Weiss, Jennifer E Weiss, Charles O Elson, Randy Q Cron, Ranjit Kumar, Casey D Morrow, Trenton R Schoeb
Studies have identified abnormalities in the microbiota of patients with arthritis. To evaluate the pathogenicity of human microbiota, we performed fecal microbial transplantation from children with spondyloarthritis and controls to germ-free KRN/B6xNOD mice. Ankle swelling was equivalent in those that received patient vs. control microbiota. Principal coordinates analysis revealed incomplete uptake of the human microbiota with over-representation of two genera (Bacteroides and Akkermansia) among the transplanted mice...
March 24, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29577747/fractures-of-the-lateral-process-of-the-talus-with-associated-ankle-instability-a-report-of-2-cases
#10
Maire-Clare Killen, Prasad Karpe, Rajiv Limaye
Fractures of the lateral process of the talus are uncommon, but often overlooked. They can result in significant functional deficit with residual nonunion and arthritis if not recognized and treated appropriately. We describe 2 cases of such injuries, one with acute recognition and management, and one with delayed diagnosis and nonunion. In both cases, pain from the fracture was accompanied by symptoms of instability requiring simultaneous lateral ligament reconstruction along with fracture fixation. Evaluation of patients with lateral process fractures should include assessment of the lateral ligaments; ankle instability may need to be surgically addressed along with intervention for fracture fixation...
March 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29577119/apoptosis-effects-of-imperatorin-on-synoviocytes-in-rheumatoid-arthritis-through-mitochondrial-caspase-mediated-pathways
#11
Ke-Feng Zhai, Hong Duan, Yuan Chen, Ghulam Jilany Khan, Wen-Gen Cao, Gui-Zhen Gao, Ling-Ling Shan, Zhao-Jun Wei
Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease associated with a potential imbalance between the growth and death of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). Imperatorin (IPT) is a naturally occurring furanocoumarin found in umbelliferous vegetables, citrus fruits, and some herbs. The effects of IPT on the proliferation and apoptosis of RA-FLSs and its potential underlying mechanisms have remained unclear. RA-FLSs obtained from RA patients were induced by interleukin-1β (IL-1β) and treated with IPT...
March 26, 2018: Food & Function
https://www.readbyqxmd.com/read/29575958/overall-benefits-provided-by-orthopedic-surgical-intervention-in-patients-with-rheumatoid-arthritis
#12
Hajime Ishikawa, Asami Abe, Toshihisa Kojima, Masayo Kojima, Naoki Ishiguro, Yumi Nomura, Hiroshi Otani, Eriko Hasegawa, Daisuke Kobayashi, Satoshi Ito, Kiyoshi Nakazono, Akira Murasawa
OBJECTIVES: To clarify systemic effects of orthopedic surgical intervention in patients with rheumatoid arthritis (RA). METHODS: A prospective observational cohort study was performed in RA patients who were scheduled to have primary elective orthopedic surgeries. Assessments were performed at baseline, 6 and 12 months after surgery using J-HAQ, General Health, EQ-5D, BDI-II, DAS28-CRP(4) and CRP for all registered patients, DASH and grip power for patients with upper-extremity surgeries, TUG for patients with lower-extremity surgeries, and JSSF for patients with ankle and forefoot surgeries...
April 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29575818/collagen-induced-arthritis-as-an-animal-model-of-rheumatoid-cachexia
#13
Paulo V G Alabarse, Priscila S Lora, Jordana M S Silva, Rafaela C E Santo, Eduarda C Freitas, Mayara S de Oliveira, Andrelise S Almeida, Mônica Immig, Vivian O N Teixeira, Lidiane I Filippin, Ricardo M Xavier
BACKGROUND: Rheumatoid arthritis is characterized by chronic polyarticular synovitis and presents systemic changes that impact quality of life, such as impaired muscle function, seen in up to 66% of the patients. This can progress to severely debilitating state known as rheumatoid cachexia-without loss of fat mass and body weight-for which there is little consensus in terms of diagnosis or treatment. This study aims to evaluate whether the collagen-induced arthritis (CIA) animal model also develops clinical and functional features characteristic of rheumatoid cachexia...
March 25, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29567573/-1-h-nmr-based-metabolomics-approach-to-investigate-the-urine-samples-of-collagen-induced-arthritis-rats-and-the-intervention-of-tetrandrine
#14
Xinming Yun, Shu Dong, Qiaoqiao Hu, Yue Dai, Yufeng Xia
Tetrandrine is an effective ingredient isolated from the roots of a frequently used medicinal plant Stephania tetrandra S. Moore. It has been used for the management of arthritis in China, but the precise mechanism remains unclear. In the present study, a metabolomics method based on the1 H NMR was constituted to quantify the alterations of the endogenous metabolites in the urines of collagen-induced arthritis (CIA) rats treated with tetrandrine. Data showed that tetrandrine treatment could alleviate the ankle joint swelling and ameliorate histopathological changes in rats...
March 14, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29555896/talar-neck-fracture-with-dislocation-combined-with-bimalleolar-ankle-fracture-a-case-report
#15
Ahmad M Radaideh, Ziad A Audat, Abdullah A Saleh
BACKGROUND Fractures of the talus are uncommon injuries that usually involve the talar neck, rather than the talar body. This report is of a rare case of combined left talar neck fracture and adjacent joint dislocation with an ipsilateral bimalleolar ankle fracture. CASE REPORT A 37-year-old man presented with an injury to his left foot following a motor vehicle accident. When he presented to the hospital emergency department, his left foot and ankle were swollen, the overlying skin was intact but badly contused, and there was no neurovascular deficit...
March 20, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29550642/a-three-year-prospective-comparative-gait-study-between-patients-with-ankle-arthrodesis-and-arthroplasty
#16
Ava D Segal, Krista M Cyr, Christina J Stender, Eric C Whittaker, Michael E Hahn, Michael S Orendurff, William R Ledoux, Bruce J Sangeorzan
BACKGROUND: End-stage ankle arthritis is a debilitating condition that often requires surgical intervention after failed conservative treatments. Ankle arthrodesis is a common surgical option, especially for younger and highly active patients; however, ankle arthroplasty has become increasingly popular as advancements in implant design improve device longevity. The longitudinal differences in biomechanical outcomes between these surgical treatments remain indistinct, likely due to the challenges associated with objective study of a heterogeneous population...
March 5, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29544526/mice-with-mir-146a-deficiency-develop-severe-gouty-arthritis-via-dysregulation-of-traf-6-irak-1-and-nalp3-inflammasome
#17
Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-Shuang Liu, Qing-Sheng Mi, Jing-Guo Zhou
BACKGROUND: MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the peripheral blood mononuclear cells of patients with inter-critical gout when compared to normouricemic and hyperuricemic controls and those patients with acute gout flares. However, the role of miR-146a in the development of gout remains unknown. Here, we used miR-146a knockout (KO) mice to test miR-146a function in a monosodium urate (MSU)-induced gouty arthritis model...
March 15, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29543869/n-3-polyunsaturated-fatty-acids-restore-th17-and-treg-balance-in-collagen-antibody-induced-arthritis
#18
Ji Young Kim, Kyu Lim, Kyung Hee Kim, Jin Hyun Kim, Jin Sun Choi, Seung-Cheol Shim
N-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and were considered useful for the treatment of rheumatoid arthritis (RA). Recently, several studies suggested that n-3 PUFAs attenuated arthritis in animal model and human, however the mechanism is still unclear. Interleukin 17 (IL-17) is a pro-inflammatory cytokine mainly produced by T helper 17 (Th17) cells which cause tissue inflammation and bone erosion leading to joint destruction. In contrast, regulatory T (Treg) cells down-regulate various immune responses by suppression of naïve T cells...
2018: PloS One
https://www.readbyqxmd.com/read/29540195/traditional-chinese-medicine-formula-bi-qi-capsule-alleviates-rheumatoid-arthritis-induced-inflammation-synovial-hyperplasia-and-cartilage-destruction-in-rats
#19
Kai Wang, Dongmei Zhang, Yan Liu, Xuan Wang, Jiantong Zhao, Tingting Sun, Tingting Jin, Baoli Li, Janak L Pathak
BACKGROUND: Traditional Chinese medicine (TCM) formula Bi-Qi capsule (Bi-Qi) is a commonly prescribed drug to treat rheumatoid arthritis (RA). However, the mechanism of Bi-Qi-mediated amelioration of RA pathogenesis is still a mystery. Collagen induced arthritis (CIA) in rats is an established model that shares many similarities with RA in humans. In this study we investigated the effect of Bi-Qi on the pathogenesis of CIA in rats. METHODS: CIA was developed in Sprague-Dawley (S...
March 14, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29540097/crocin-exerts-anti-inflammatory-and-anti-arthritic-effects-on-type-ii-collagen-induced-arthritis-in-rats
#20
Wei Liu, Yufeng Sun, Zhenping Cheng, Yong Guo, Peiming Liu, Ying Wen
CONTEXT: Rheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models. OBJECTIVE: This study investigates the anti-inflammatory and anti-arthritic effects of crocin on type II collagen-induced arthritis (CIA) in Wistar rats. MATERIALS AND METHODS: The CIA rat model was established and randomly divided into five groups with or without crocin treatment (10, 20 or 40 mg/kg), which was started on day 21 after arthritis induction and persisted for 36 days...
December 2018: Pharmaceutical Biology
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