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ankle arthritis

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https://www.readbyqxmd.com/read/29909689/intra-articular-injections-in-the-treatment-of-symptoms-from-ankle-arthritis-a-systematic-review
#1
Christopher Vannabouathong, Gina Del Fabbro, Brendan Sales, Christopher Smith, Chuan Silvia Li, Darryl Yardley, Mohit Bhandari, Bradley A Petrisor
BACKGROUND: Intra-articular (IA) injections are commonly used to treat knee arthritis pain; however, whether their efficacy generalizes to ankle arthritis remains debatable. We aimed to evaluate the evidence for IA therapies in the management of this patient population. METHODS: We performed a literature search for observational and randomized controlled trials (RCTs). Treatments included corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), and mesenchymal stem cells (MSC)...
June 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29899668/retrocalcaneal-bursitis-precedes-or-accompanies-achilles-tendon-enthesitis-in-the-early-phase-of-rheumatoid-arthritis
#2
Takeshi Suzuki, Yuka Hidaka, Yu Seri
The consecutive reports and stored images of ultrasound examinations for 100 symptomatic ankles of 74 patients with rheumatoid arthritis (RA) were reviewed for the presence or absence of retrocalcaneal bursitis (RCB) and Achilles tendon enthesitis (ATE). The ankles were classified into 4 categories based on the presence or absence of RCB or ATE. The number of RCB(-)/ATE(-), RCB(+)/ATE(-), RCB(+)/ATE(+), and RCB(-)/ATE(+) ankles was 62, 16, 12, and 10, respectively. When classifying patients into early RA and established RA, the percentage of RCB(-)/ATE(+) ankles with early RA was significantly lower than that with established RA ( P  = ...
2018: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29891129/severe-ankle-arthritis-after-multiple-hemarthrosis-secondary-to-factor-xi-deficiency-a-case-report
#3
Steven M Douthett, Lawrence Fallat
Hemophilic arthropathy of the ankle is an extremely unique condition that affects a small subset of the population in the United States. We present the case of a 66-year-old male with factor XI deficiency, which, over years of repetitive microtrauma as a professional soccer player, led to multiple hemarthrosis and severe arthropathy of his right ankle. The patient successfully underwent total ankle replacement arthroplasty and was able to return to recreational sports and competitive road cycling.
June 8, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29867985/anti-inflammatory-effects-of-hdl-in-mice-with-rheumatoid-arthritis-induced-by-collagen
#4
Yunlong Wang, Shulai Lu, Guoqing Zhang, Shaofeng Wu, Ying Yan, Qingzhe Dong, Bin Liu
Objective: To investigate the anti-inflammatory effects of high-density lipoprotein (HDL) in mice with rheumatoid arthritis (RA) induced by collagen. Methods: Male DBA/1 mice (8-week-old) were divided into three groups: control (treated with saline), collagen-induced arthritis (CIA), and CIA + HDL. CIA was induced with bovine type II collagen, and after the injection of bovine type II collagen, the CIA + HDL group received an injection of HDL on day 28 followed by HDL injections four times every 3 days...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29865282/treadmill-running-ameliorates-destruction-of-articular-cartilage-and-subchondral-bone-not-only-synovitis-in-a-rheumatoid-arthritis-rat-model
#5
Seiji Shimomura, Hiroaki Inoue, Yuji Arai, Shuji Nakagawa, Yuta Fujii, Tsunao Kishida, Shohei Ichimaru, Shinji Tsuchida, Toshiharu Shirai, Kazuya Ikoma, Osam Mazda, Toshikazu Kubo
We analyzed the influence of treadmill running on rheumatoid arthritis (RA) joints using a collagen-induced arthritis (CIA) rat model. Eight-week-old male Dark Agouti rats were randomly divided into four groups: The control group, treadmill group (30 min/day for 4 weeks from 10-weeks-old), CIA group (induced CIA at 8-weeks-old), and CIA + treadmill group. Destruction of the ankle joint was evaluated by histological analyses. Morphological changes of subchondral bone were analyzed by μ-CT. CIA treatment-induced synovial membrane invasion, articular cartilage destruction, and bone erosion...
June 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29862841/factors-influencing-functional-outcomes-of-subtalar-fusion-for-posttraumatic-arthritis-after-calcaneal-fracture
#6
Quirine M J van der Vliet, Falco Hietbrink, Fabio Casari, Luke P H Leenen, Marilyn Heng
BACKGROUND: Subtalar arthrodesis is a common salvage operation for posttraumatic subtalar arthritis. This study aimed to identify factors associated with functional outcomes and quality of life after subtalar fusion for posttraumatic subtalar arthritis after calcaneal fracture. METHODS: This is a retrospective study with follow-up by questionnaire in two level 1 trauma centers. Patients who underwent subtalar arthrodesis for posttraumatic arthritis after a calcaneal fracture between 2001 and 2016 were identified and contacted for completion of a survey consisting of the Foot and Ankle Ability Measure (FAAM), Maryland Foot Score (MFS), Patient-Reported Outcomes Measurement System Physical Function (PROMIS PF, Short Form 10a) questionnaire, EuroQol 5-dimensional (EQ-5D) questionnaire, and EuroQol visual analog scale (EQ-VAS)...
June 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29862046/psoriasis-and-the-risk-of-foot-and-ankle-tendinopathy-or-enthesopathy-in-the-absence-of-psoriatic-arthritis-a-population-based-study
#7
Ryan T Lewinson, Isabelle A Vallerand, Laurie M Parsons, Jeremy M LaMothe, Alexandra D Frolkis, Mark W Lowerison, Gilaad G Kaplan, Scott B Patten, Cheryl Barnabe
Objectives: Imaging studies in patients with cutaneous psoriasis have demonstrated asymptomatic bone and tendon changes, commonly of the foot and ankle. We sought to determine if patients with cutaneous psoriasis have an increased risk of clinically significant foot and ankle tendinopathy or enthesopathy compared with the general population. Methods: Patients with cutaneous psoriasis and a general population cohort were identified in The Health Improvement Network, a general practice medical records database from the UK...
2018: RMD Open
https://www.readbyqxmd.com/read/29845429/juvenile-idiopathic-arthritis-in-the-biologic-era-predictors-of-the-disease-progression-and-need-for-early-introduction-of-biologic-treatment
#8
Panayiota Nalbanti, Florentia Kanakoudi-Tsakalidou, Maria Trachana, Polyxeni Pratsidou-Gertsi, Evangelia Farmaki, Panagiotis Bamidis, Fotios Papachristou
To assess longitudinally the course and outcome of juvenile idiopathic arthritis (JIA) in patients diagnosed and followed-up exclusively in the biologic era; also, to define possible predictors of the disease progression and need for early implementation of biologicals. Prospective and retrospective, monocentric cohort study of 120 JIA patients, diagnosed between 2001 and 2010, and followed-up for ≥ 4 years (median 8.04). Disease activity, cumulative articular/extra-articular damage and quality of life were evaluated by the assessment tools Juvenile Arthritis Disease Activity Score (JADAS71), Juvenile Arthritis Damage Index (JADI) and Childhood Health Assessment Questionnaire (CHAQ), respectively...
May 29, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29845371/-syndesmosis-injuries-at-the-ankle
#9
REVIEW
S Rammelt, E Manke
BACKGROUND: Injuries to the distal tibiofibular syndesmosis are frequent and continue to generate controversy due to an extensive range of diagnostic techniques and therapeutic options. OBJECTIVE: The aim of this review is to summarize the current knowledge on syndesmotic instability and to present some recommendations for the clinical practice for acute an chronic injuries. MATERIAL AND METHODS: Analysis of the current literature concerning the anatomy, etiology, diagnostics and treatment of syndesmosis injuries...
May 29, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29806320/-application-of-three-dimensional-printing-in-the-operation-of-distal-tibia-fracture-involving-epiphyseal-plate-injury-for-teenagers
#10
Jingxin Zhao, Yachang Ma, Dong Han, Yu Jin
Objective: To investigate the application value of three-dimensional (3-D) printing technology in the operation of distal tibia fracture involving epiphyseal plate injury for teenagers. Methods: The retrospective analysis was conducted on the clinical data of 16 cases of children patients with distal tibia fracture involving epiphyseal plate injury undergoing the operation by using of 3-D printing technology between January 2014 and December 2015. There were 12 males and 4 females with an age of 9-14 years (mean, 12...
October 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29798584/-application-of-three-dimensional-printing-technology-for-closed-reduction-and-percutaneous-cannulated-screws-fixation-of-displaced-intraarticular-calcaneus-fractures
#11
Min Wu, Jianzhong Guan, Yuzhou Xiao, Zhaodong Wang, Xiaotian Chen, Zhi Zhao, Kuankuan Zhang, Jun Zhu
Objective: To evaluate the effectiveness of three-dimensional (3-D) printing assisting minimally invasive for intraarticular calcaneal fractures with percutaneous poking reduction and cannulate screw fixation. Methods: A retrospective analysis was performed of the 19 patients (19 feet) with intraarticular calcaneal fracture who had been treated between March 2015 and May 2016. There were 13 males and 6 females with an average age of 38.2 years (range, 24-73 years)...
November 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29798583/-effectiveness-analysis-of-ilizarov-external-fixation-and-ankle-arthrodesis-in-treatment-of-late-traumatic-ankle-arthritis
#12
Jun Li, Zeyu Huang, Yue Fang, Fuguo Huang, Lei Liu
Objective: To evaluate the effectiveness of Ilizarov external fixation and ankle arthrodesis in the treatment of late traumatic ankle arthritis. Methods: Between June 2013 and June 2015, 27 patients with late traumatic ankle arthritis were treated with Ilizarov external fixation technique. There were 16 males and 11 females with an age of 27-69 years (mean, 45.7 years). Sixteen cases were on the left side, 11 on the right side. All the patients suffered from traumatic ankle fractures or ligament damages caused by initial traumas...
November 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29763636/inhibition-of-cox-2-mpges-1-and-5-lox-in-macrophages-by-leonurine-ameliorates-monosodium-urate-crystal-induced-inflammation
#13
Yanzhuo Liu, Chenfan Duan, Honglei Chen, Chenlong Wang, Xiaoxiao Liu, Miao Qiu, Honglin Tang, Feng Zhang, Xiaoyang Zhou, Jing Yang
Cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and microsomal prostaglandin E synthase-1 (mPGES-1)-derived eicosanoids play an essential role in human inflammatory disorders. Here, we investigated whether inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate (MSU) crystal-induced inflammation. Virtual screening assay and in vitro enzyme inhibition assay showed that leonurine was a potential inhibitor of COX-2, mPGES-1 and 5-LOX. Compared with COX-2 inhibitor celecoxib, leonurine (30 mg/kg) significantly decreased ankle perimeter, gait score and neutrophil number in synovial fluid in MSU crystal-treated rats, accompanied with the decreased expression of COX-2, mPGES-1 and 5-LOX and production of prostaglandin E2 (PGE2 ) and leukotriene B4 (LTB4 ) in the synovial fluid macrophages...
May 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29761747/changes-in-hindfoot-alignment-after-high-or-low-tibial-osteotomy
#14
Jun Young Choi, Si Jung Song, Sung Jung Kim, Sang Hee Kim, Ji Soo Park, Jin Soo Suh
BACKGROUND: We aimed to determine the change in hindfoot alignment after high (HTO) or low tibial osteotomy (LTO), which is commonly performed to prevent the progression of arthritis of the knee or ankle. METHODS: We retrospectively reviewed the radiographic findings of patients who underwent HTO or LTO for arthritis with varus deformity of the knee or ankle joint. The hindfoot alignment view angle (HAVA), hindfoot alignment ratio (HAR), and hindfoot moment arm (HMA) were measured using the hindfoot alignment radiographs...
May 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29759083/hypertrophic-osteoarthropathy-mimicking-a-reactive-arthritis-a-case-report-and-review-of-the-literature
#15
Francesco Bozzao, Stella Bernardi, Franca Dore, Lorenzo Zandonà, Fabio Fischetti
BACKGROUND: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and periosteal tissues of the extremities. It can be a rare hereditary disease (pachydermoperiostosis) or can be secondary to various diseases, though mostly lung malignancies. Here, we report an unusual clinical presentation of HOA. CASE PRESENTATION: A 77-year-old man presented with fever, diarrhea, and an oligoarthritis involving the left knee and the ankles...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29753098/anti-arthritic-activities-of-ethanol-extracts-of-circaea-mollis-siebold-zucc-whole-plant-in-rodents
#16
Yanhong Yu, Qing Zhang, Jiajia Li, Yeli Guan, Jiangeng Huang, Zhiping Wang, Zhen Zhang, Wenrui Zhang, Jing Guo, Jinghua Li, Jiachun Chen, Qun Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Circaea mollis Siebold & Zucc., a genus of Circaea that follows Onagraceae, has been used for centuries as a folk herb in traditional Chinese medicine (TCM) and Hani Ethnopharmacy for the treatment of joint swelling and pain in rheumatoid arthritis. AIM OF THE STUDY: This study was designed to confirm anti-arthritic effects and its underlying mechanism of ethanol extracts of Circaea mollis Siebold & Zucc. (EEC), which may contribute to provide the pharmacological basis in the treatment of rheumatoid disease...
May 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29750395/adamts-12-protects-against-inflammatory-arthritis-through-interacting-with-and-inactivating-proinflammatory-ctgf
#17
Jian-Lu Wei, Wenyu Fu, Aubryanna Hettinghouse, Wen-Jun He, Kenneth E Lipson, Chuan-Ju Liu
OBJECTIVE: It has been reported that a disintegrin and metalloproteinase with thrombospondin motifs-12 (ADAMTS-12) is a susceptibility gene for rheumatoid arthritis (RA) development, and its level is significantly increased in RA patients. In addition, ADAMTS-12 was also reported to be required for normal inflammation. This study aims to determine the role of ADAMTS-12 and the underlying mechanisms in the pathogenesis of inflammatory arthritis. METHODS: The collagen-induced arthritis (CIA) model was established in ADAMTS-12-deficient mice and their control littermates to determine the role of ADAMTS-12 in vivo; microCT scanning was used to demonstrate the destruction of ankle joint; histological analysis illustrated synovitis, pannus formation, as well as bone and cartilage destruction; ELISA was performed to measure serum levels of inflammatory cytokines; Protein-protein interaction assays were performed to detect the interactions of ADAMTS-12 and its various deletion mutants with connective tissue growth factor (CTGF)...
May 11, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29743920/electroacupuncture-alleviates-pain-responses-and-inflammation-in-a-rat-model-of-acute-gout-arthritis
#18
Wenxin Chai, Yan Tai, Xiaomei Shao, Yi Liang, Guo-Qing Zheng, Ping Wang, Jianqiao Fang, Boyi Liu
Acute gout arthritis is one of the most painful inflammatory conditions. Treatments for gout pain are limited to colchicine, nonsteroidal anti-inflammatory drugs, and corticosteroids, which oftentimes result in severe adverse effects. Electroacupuncture (EA) has been proved to be effective in relieving many inflammatory pain conditions with few side effects. Here, we aim to investigate the therapeutic potentials of EA on pain and inflammation of a rat model of acute gout arthritis and underlying mechanisms...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29742468/native-septic-arthritis-is-not-an-immediate-surgical-emergency
#19
Nicolas Lauper, Marie Davat, Ergys Gjika, Camillo Müller, Wilson Belaieff, Didier Pittet, Benjamin A Lipsky, Didier Hannouche, Ilker Uçkay
Acute native joint septic arthritis is generally considered a surgical emergency, requiring drainage within hours, including during night, weekend or holiday shifts. However, there are few data supporting the need for the disruption caused by this degree of urgency. METHODS: We performed a retrospective review of all adult patients seen in our medical center from 1997-2015 with culture-proven septic arthritis and noted the epidemiology of sequelae, and their possible association with a delay in surgical drainage...
May 6, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29739760/primary-meningococcal-septic-arthritis-with-multiple-native-joint-involvement
#20
Connor Boyle, Thomas Howard, David Griffith, Jonathan Cowie
A previously healthy 18-year-old woman presented with an acutely painful, swollen right ankle joint, with similar symptoms subsequently developing in the right hip and right wrist. Microbiological samples from the ankle aspirate grew Neisseria meningitidis She had had no preceding clinical symptoms of meningitis or previous contact with a patient with meningitis. She was treated with intravenous antibiotics and surgical drainage.On follow-up, her symptoms had resolved, inflammatory markers had returned to normal and she has no long-term sequelae of septic arthritis...
May 8, 2018: BMJ Case Reports
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