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Plate rich plasma treatments

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https://www.readbyqxmd.com/read/27148928/the-efficacy-of-platelet-rich-plasma-in-the-treatment-of-rib-fractures
#1
Samil Gunay, Huseyin Candan, Rahsan Yılmaz, Irfan Eser, Umit Aydoğmus
Background Rib fracture is the most common result of thoracic traumas. Intrapulmonary shunt, alveolar capillary membrane damage, intra-alveolar hemorrhage, and hypoxia may develop following rib fractures. Therefore, prompt treatment is important. The aim of this experimental study was to analyze the effects of platelet-rich plasma (PRP) on rib fractures to secure a speedier and more efficient treatment method. Materials and Methods The study involved 18 New Zealand white rabbits, randomly divided into three groups as Group 1, the sham group with no surgical intervention; Group 2, the control group in which simple rib fractures were applied and no treatment; and Group 3, in which rib fractures were applied and then PRP treatment was administered...
May 5, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/26886592/serum-collagen-type-ii-cleavage-epitope-and-serum-hyaluronic-acid-as-biomarkers-for-treatment-monitoring-of-dogs-with-hip-osteoarthritis
#2
José M Vilar, Mónica Rubio, Giuseppe Spinella, Belén Cuervo, Joaquín Sopena, Ramón Cugat, Montserrat Garcia-Balletbó, Juan M Dominguez, Maria Granados, Asta Tvarijonaviciute, José J Ceron, José M Carrillo
The aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment...
2016: PloS One
https://www.readbyqxmd.com/read/26460099/leukocyte-reduced-platelet-rich-plasma-normalizes-matrix-metabolism-in-torn-human-rotator-cuff-tendons
#3
Jessica A Cross, Brian J Cole, Kaylan P Spatny, Emily Sundman, Anthony A Romeo, Greg P Nicholson, Bettina Wagner, Lisa A Fortier
BACKGROUND: The optimal platelet-rich plasma (PRP) for treatment of supraspinatus tendinopathy has not been determined. PURPOSE: To evaluate the effect of low- versus high-leukocyte concentrated PRP products on catabolic and anabolic mediators of matrix metabolism in diseased rotator cuff tendons. STUDY DESIGN: Controlled laboratory study. METHODS: Diseased supraspinatus tendons were treated with PRP made by use of 2 commercial systems: Arthrex Autologous Conditioned Plasma Double Syringe System (L(lo) PRP) and Biomet GPS III Mini Platelet Concentrate System (L(hi) PRP)...
December 2015: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26428302/the-nesh-abi-3-based-wave2-complex-is-functionally-distinct-from-the-abi-1-based-wave2-complex
#4
Saki Sekino, Yuriko Kashiwagi, Hitoshi Kanazawa, Kazuki Takada, Takashi Baba, Seiichi Sato, Hiroki Inoue, Masaki Kojima, Katsuko Tani
BACKGROUND: Abl interactor (Abi) family proteins play significant roles in actin cytoskeleton organization through participation in the WAVE complex. Mammals possess three Abi proteins: Abi-1, Abi-2, and NESH/Abi-3. Abi-1 and Abi-2 were originally identified as Abl tyrosine kinase-binding proteins. It has been disclosed that Abi-1 acts as a bridge between c-Abl and WAVE2, and c-Abl-mediated WAVE2 phosphorylation promotes actin remodeling. We showed previously that NESH/Abi-3 is present in the WAVE2 complex, but neither binds to c-Abl nor promotes c-Abl-mediated phosphorylation of WAVE2...
2015: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/25990927/assisted-deposition-of-nano-hydroxyapatite-onto-exfoliated-carbon-nanotube-oxide-scaffolds
#5
H Zanin, C M R Rosa, N Eliaz, P W May, F R Marciano, A O Lobo
Electrodeposited nano-hydroxyapatite (nHAp) is more similar to biological apatite in terms of microstructure and dimension than apatites prepared by other processes. Reinforcement with carbon nanotubes (CNTs) enhances its mechanical properties and increases adhesion of osteoblasts. Here, we carefully studied nHAp deposited onto vertically aligned multi-walled CNT (VAMWCNT) scaffolds by electrodeposition and soaking in a simulated body fluid (SBF). VAMWCNTs are porous biocompatible scaffolds with nanometric porosity and exceptional mechanical and chemical properties...
June 14, 2015: Nanoscale
https://www.readbyqxmd.com/read/25404629/results-of-the-use-of-platelet-rich-plasma-in-the-treatment-of-delayed-union-of-long-bones
#6
Justyna Gołos, Tomasz Waliński, Piotr Piekarczyk, Krzysztof Kwiatkowski
BACKGROUND: The aim of this study was to assess the efficacy of platelet rich plasma in the treatment of delayed union of long bones according to fracture location, the time between the fracture and PRP administration, and the type of surgical fixation. MATERIAL AND METHODS: A total of 1620 patients with long bone fractures were treated surgically at the Department of Traumatology of the Military Medical Institute in Warsaw between 2009 and 2012. Delayed union was diagnosed in 158 (9...
July 2014: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/25108907/comparative-outcomes-of-open-wedge-high-tibial-osteotomy-with-platelet-rich-plasma-alone-or-in-combination-with-mesenchymal-stem-cell-treatment-a-prospective-study
#7
COMPARATIVE STUDY
Yong-Gon Koh, Oh-Ryong Kwon, Yong-Sang Kim, Yun-Jin Choi
PURPOSE: This study compared the clinical results and second-look arthroscopic findings of patients undergoing open-wedge high tibial osteotomy (HTO) for varus deformity, with or without mesenchymal stem cell (MSC) therapy. METHODS: This prospective, comparative observational study was designed to evaluate the effectiveness of MSC therapy. The patients were divided into 2 groups: HTO with platelet-rich plasma (PRP) injection only (n = 23) or HTO in conjunction with MSC therapy and PRP injection (n = 21)...
November 2014: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/25108654/platelet-rich-plasma-affects-bacterial-growth-in-vitro
#8
Erminia Mariani, Giuseppe Filardo, Valentina Canella, Andrea Berlingeri, Alessandra Bielli, Luca Cattini, Maria Paola Landini, Elizaveta Kon, Maurilio Marcacci, Andrea Facchini
BACKGROUND AIMS: Platelet-rich plasma (PRP), a blood derivative rich in platelets, is a relatively new technique used in tissue regeneration and engineering. The increased quantity of platelets makes this formulation of considerable value for their role in tissue healing and microbicidal activity. This activity was investigated against five of the most important strains involved in nosocomial infections (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae and Streptococcus faecalis) to understand the prophylactic role of pure (P)-PRP...
September 2014: Cytotherapy
https://www.readbyqxmd.com/read/23395471/an-in-vitro-evaluation-of-the-anti-inflammatory-effects-of-platelet-rich-plasma-ketorolac-and-methylprednisolone
#9
Augustus D Mazzocca, Mary Beth R McCarthy, Jessica Intravia, Knut Beitzel, John Apostolakos, Mark P Cote, James Bradley, Robert A Arciero
PURPOSE: The purpose of this study was to quantify the extent of the anti-inflammatory effect of platelet-rich plasma (PRP) in a controlled in vitro environment. METHODS: Through the stimulation of human umbilical vein endothelial cells with inflammatory cytokines (tumor necrosis factor α and interferon γ), cell adhesion molecule expression (E-selectin, vascular cell adhesion molecule, and human leukocyte antigen DR) and PRP's anti-inflammatory effect can be measured...
April 2013: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/22325997/results-of-calcaneocuboid-distraction-arthrodesis
#10
COMPARATIVE STUDY
Todd R Grunander, David B Thordarson
BACKGROUND: One powerful method of reconstructing an adult acquired flatfoot deformity is a calcaneocuboid distraction arthrodesis. We performed a retrospective review of a small series of patients who underwent a calcaneocuboid distraction arthrodesis with a femoral head allograft. MATERIALS AND METHODS: Sixteen feet (14 patients) were identified with an average follow up of 23 months (8-39 months) and an average age of 43 years (16-60 years). A calcaneocuboid distraction arthrodesis was performed with a femoral head allograft, secured with a 3 hole 1/3 tubular plate with 7 of the grafts being supplemented with platelet rich plasma (PRP)...
March 2012: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/22260455/enhanced-cellular-responses-of-human-bone-marrow-stromal-cells-cultured-on-pre-treated-surface-with-allogenic-platelet-rich-plasma
#11
Seung Han Shin, Jeong Joon Yoo, Ha Na Kim, Jinwoo Nam, Hee Joong Kim
Abstract The principal objective of this study was to evaluate the effects of surface pre-treatment with platelet-rich plasma (PRP) on the cellular functions of human bone marrow stromal cells (hBMSCs). The surfaces of tissue culture plates (TCPs) were pre-treated by adding PRP followed by centrifugation to bring platelets closer to the surface, followed by incubation for 60 min at 37°C. Then, hBMSCs were seeded onto TCP and TCP pre-treated with PRP (TCP-PRP), followed by culture in osteogenic medium. Cell attachment, proliferation, and osteogenic differentiation were evaluated...
January 19, 2012: Connective Tissue Research
https://www.readbyqxmd.com/read/21814354/treatment-of-endodontically-induced-periapical-lesions-using-hydroxyapatite-platelet-rich-plasma-and-a-combination-of-both-an-in-vivo-study
#12
C Vaishnavi, B Mohan, L Lakshmi Narayanan
AIM AND OBJECTIVES: To evaluate bone regeneration in endodontically induced periapical lesions using Hydroxyapatite, Platelet-Rich Plasma (PRP), and a combination of Hydroxyapatite and Platelet-Rich Plasma for a period of one year. MATERIALS AND METHODS: Twenty systemically healthy patients of both genders between the ages 20 and 40 years were included. To qualify, the patient had to have a tooth where non-surgical root canal therapy had failed, periapical radiolucency was present, and periapical root end surgery was required...
April 2011: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/20633974/reconstruction-of-the-mandible-using-preshaped-2-3-mm-titanium-plates-autogenous-cortical-bone-plates-particulate-cancellous-bone-and-platelet-rich-plasma-a-retrospective-analysis-of-20-patients
#13
MULTICENTER STUDY
Robert E C M Mooren, Matthias A W Merkx, Peter A W H Kessler, John A Jansen, Paul J W Stoelinga
PURPOSE: The purpose of this retrospective study was to evaluate a group of 20 patients who underwent a reconstruction of the mandible by use of free bone grafts and platelet-rich plasma (PRP). MATERIALS AND METHODS: In a period of 8 years, 20 patients underwent a reconstruction of the mandible, by use of preshaped 2.3-mm titanium plates, autogenous cortical bone plates, autogenous particulate bone, PRP, and a special fixation technique. The patients were divided into 3 groups...
October 2010: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/18155752/variable-responsiveness-to-clopidogrel-and-aspirin-among-patients-with-acute-coronary-syndrome-as-assessed-by-platelet-function-tests
#14
COMPARATIVE STUDY
Boris Shenkman, Shlomi Matetzky, Paul Fefer, Hanoch Hod, Yulia Einav, Aharon Lubetsky, David Varon, Naphtali Savion
Unresponsiveness to clopidogrel or aspirin has been reported in patients with acute coronary syndrome (ACS). Platelet aggregometry (PA) and the Impact-R [Cone and Plate(let) Analyzer (CPA) technology, measuring whole blood platelet adhesion under flow conditions] were compared in detecting laboratory unresponsiveness to clopidogrel and aspirin among ACS patients. Platelet-rich plasma (PRP) samples were evaluated in 404 patients by PA using adenosine diphosphate (ADP) and arachidonic acid (AA) and whole blood samples by the Impact-R ADP- and AA-response tests...
2008: Thrombosis Research
https://www.readbyqxmd.com/read/17674679/immediate-bone-augmentation-after-infected-tooth-extraction-using-titanium-membranes
#15
Efraim Kfir, Vered Kfir, Edo Kaluski
Infectious process frequently results in extensive bone resorption and defect, periradicular or periapical lesions, or vertical fracture with infected sinus tract. When tooth extraction is mandated it typically results in additional bone loss in the buccal or lingual cortical plate. Immediate guided bone regeneration (GBR) and implant fixation at an infected site is frequently complicated by soft-tissue dehiscence, membrane exposure, and implant failure. The objective of this research is to assess the feasibility of immediate bone augmentation (IBA) after purulent tooth extraction, employing a dedicated titanium membrane...
2007: Journal of Oral Implantology
https://www.readbyqxmd.com/read/17356164/antibacterial-effect-of-autologous-platelet-gel-enriched-with-growth-factors-and-other-active-substances-an-in-vitro-study
#16
T M Bielecki, T S Gazdzik, J Arendt, T Szczepanski, W Król, T Wielkoszynski
Platelet-rich plasma is a new inductive therapy which is being increasingly used for the treatment of the complications of bone healing, such as infection and nonunion. The activator for platelet-rich plasma is a mixture of thrombin and calcium chloride which produces a platelet-rich gel. We analysed the antibacterial effect of platelet-rich gel in vitro by using the platelet-rich plasma samples of 20 volunteers. In vitro laboratory susceptibility to platelet-rich gel was determined by the Kirby-Bauer disc-diffusion method...
March 2007: Journal of Bone and Joint Surgery. British Volume
https://www.readbyqxmd.com/read/17074719/the-effects-of-estrone-estradiol-and-estriol-on-platelet-aggregation-induced-by-adrenaline-and-adenosine-diphosphate
#17
Pravit Akarasereenont, Pinpat Tripatara, Sirikul Chotewuttakorn, Titchaporn Palo, Athiwat Thaworn
The impact of estrogens on the cardiovascular system and their ability to regulate platelet functions remains controversial. Changes in platelet functions could contribute to thrombotic risk associated with estrogen treatments. Here, we investigated the effects of various forms of estrogen, including estrone (E1), estradiol (E2) and estriol (E3), on platelet aggregation induced by standard agonists (adrenaline and adenosine diphosphate). Platelet-rich plasma (PRP) was prepared from citrated blood donated by 25 normal volunteers...
November 2006: Platelets
https://www.readbyqxmd.com/read/16978240/venlafaxine-induced-ecchymoses-and-impaired-platelet-aggregation
#18
Anita Sarma, McDonald K Horne
OBJECTIVE: To describe a case of venlafaxine-induced ecchymoses. METHODS: A patient with a history of ecchymoses coincident with venlafaxine therapy was rechallenged with the drug. Her platelet function was assessed with aggregation and ATP release studies before the rechallenge and after she developed ecchymoses. In addition, the effect of venlafaxine on platelet aggregation and ATP release was studied in vitro by adding the drug to platelet-rich plasma from normal donors...
December 2006: European Journal of Haematology
https://www.readbyqxmd.com/read/16439100/reconstruction-of-the-mandible-after-ablative-surgery-for-the-treatment-of-aggressive-benign-odontogenic-tumours-in-tanzania-a-preliminary-study
#19
E N M Simon, M A W Merkx, F M Shubi, B M Kalyanyama, P J W Stoelinga
This study presents results on 11 patients suffering from ameloblastoma who had ablative surgery followed by reconstruction of the mandible in a single operative procedure in Tanzania. The procedure included the use of autogenous particulate bone from the anterior or posterior iliac crest. In 6 of the patients, the tumour was removed from the cortical scaffold, which was then irradiated with 50 Gy. Perforations were made on the scaffold and it was then placed back to fit the defect and was held in place by custom-made titanium plates, fixed on both ends with screws...
May 2006: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/16144440/reconstruction-of-the-mandible-with-a-poly-d-l-lactide-scaffold-autogenous-corticocancellous-bone-graft-and-autogenous-platelet-rich-plasma-an-animal-experiment
#20
Jeroen P M Fennis, Paul J W Stoelinga, Matthias A W Merkx, John A Jansen
An animal study is presented, evaluating a method of mandibular reconstruction using a poly(D,Llactide) (PDLLA) scaffold. Six goats underwent a continuity resection of the mandibular angle. The defect was bridged with a preshaped PDLLA scaffold, filled with an autogenous particulate bone graft from the anterior iliac crest, and fixed with two preshaped titanium plates. To accelerate bone healing, autogenous platelet-rich plasma was mixed with the particulate bone graft. All goats had an uneventful healing. The osteosynthesis system withstood immediate loading for a period of 6 weeks until sacrifice...
July 2005: Tissue Engineering
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