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https://www.readbyqxmd.com/read/29165598/fetal-growth-and-birth-anthropometrics-in-metformin-exposed-offspring-born-to-mothers-with-pcos
#1
Anna Hjorth-Hansen, Øyvind Salvesen, Liv Guro Engen Hanem, Torbjørn Eggebø, Kjell Å Salvesen, Eszter Vanky, Rønnaug Ødegård
Context: Metformin is used in attempt to reduce pregnancy complications associated with polycystic ovary syndrome (PCOS). Little is known about the metformin impact on fetal development and growth. Objectives: Exploring the metformin effect vs. placebo on fetal growth and birth anthropometrics in PCOS-offspring compared to a reference population in relation to maternal BMI. Design: Post-hoc analysis of an RCT. Setting: Double-blind, placebo-controlled, multicenter study...
November 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165138/a-relationship-between-a-level-of-hemoglobin-after-delivery-and-exclusive-breastfeeding-initiation-at-a-baby-friendly-hospital-in-japan
#2
Saki Horie, Kyoko Nomura, Shinichi Takenoshita, Junko Nakagawa, Michiko Kido, Mitsuhiro Sugimoto
BACKGROUND: The recent National Nutrition Survey of 2013 demonstrated that 16.7% of women in childbearing age are underweight, and 5.0-10.0% of these women manifested a Hemoglobin (Hb) level less than 11.0 g/dl. The purpose of this study was to investigate if such maternal nutritional status affects success of exclusive breastfeeding (EBF) practice. METHODS: This cross-sectional study investigated 1532 dyads of mothers and infants with full-term singleton pregnancies delivered during 2011 at a perinatal center in Tokyo...
April 20, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165130/determinants-of-polyunsaturated-fatty-acid-concentrations-in-erythrocytes-of-pregnant-japanese-women-from-a-birth-cohort-study-study-protocol-and-baseline-findings-of-an-adjunct-study-of-the-japan-environment-children-s-study
#3
Shoji Saito, Terue Kawabata, Nozomi Tatsuta, Fumiko Kimura, Teruo Miyazawa, Satoshi Mizuno, Hidekazu Nishigori, Takahiro Arima, Yasuo Kagawa, Kouichi Yoshimasu, Kanami Tsuno, Yuki Ito, Michihiro Kamijima, Kunihiko Nakai, Nobuo Yaegashi
BACKGROUND: N-3 polyunsaturated fatty acids (n-3 PUFA) may have multiple beneficial effects on the outcome of pregnancy, maternal health and child development. The present study introduced the protocol of a birth cohort study to examine the beneficial effects of n-3 PUFA status in pregnant Japanese women as an adjunct study of the Japan Environment and Children's Study (JECS). METHODS: The JECS participants in the coastal areas of Miyagi Prefecture were further invited to participate in this adjunct study, and 1,878 pregnant women were enrolled prior to delivery...
April 4, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164597/maternal-body-mass-index-as-a-predictor-for-delivery-method
#4
Anita Pettersen-Dahl, Gulim Murzakanova, Leiv Sandvik, Katariina Laine
INTRODUCTION: High maternal body mass index (BMI) is associated with complications during pregnancy and delivery, such as gestational diabetes, hypertensive disorders, perineal injuries and macrosomia. The aim of this study was to assess the association between maternal BMI and delivery method in non-breech, singleton deliveries, after 36 weeks of gestation, in women with no more than one previous cesarean section, in Oslo University hospital, Ullevål. MATERIAL AND METHODS: This retrospective register study used data from the hospital obstetrical database in 2011-2012, forming a cohort of 8821 women...
November 22, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29164116/potential-of-metformin-to-improve-cardiac-risk-in-postpartum-women-with-gestational-diabetes
#5
Oscar A Viteri, Mary Alice Sallman, Pauline M Berens, Pamela D Berens, Farah H Amro, Maria S Hutchinson, Susan M Ramin, Sean C Blackwell, Jerrie S Refuerzo, Judith A Smith
Objective: Pregnancy is associated with an increase in total cholesterol, high density lipoproteins (HDL), and low-density lipoproteins (LDL). Postpartum, HDL and LDL decrease over the first 12 weeks postpartum. Oxidized LDL (ox-LDL) is a marker of oxidative stress-related inflammation, which is associated with obesity and also with development of cardiovascular disease. Cardiovascular protection and weight loss are benefits from metformin, especially in women with diabetes. The objective of this study was to compare changes in lipid profiles and biomarkers for obesity during the initial 6 weeks postpartum between women with gestational diabetes mellitus (GDM) treated with metformin versus placebo...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29163945/pregnancy-associated-death-in-record-linkage-studies-relative-to-delivery-termination-of-pregnancy-and-natural-losses-a-systematic-review-with-a-narrative-synthesis-and-meta-analysis
#6
David C Reardon, John M Thorp
Objectives: Measures of pregnancy associated deaths provide important guidance for public health initiatives. Record linkage studies have significantly improved identification of deaths associated with childbirth but relatively few have also examined deaths associated with pregnancy loss even though higher rates of maternal death have been associated with the latter. Following PRISMA guidelines we undertook a systematic review of record linkage studies examining the relative mortality risks associated with pregnancy loss to develop a narrative synthesis, a meta-analysis, and to identify research opportunities...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29163937/development-and-validation-of-a-simplified-algorithm-for-neonatal-gestational-age-assessment-protocol-for-the-alliance-for-maternal-newborn-health-improvement-amanhi-prospective-cohort-study
#7
Abdullah Baqui, Parvez Ahmed, Sushil Kanta Dasgupta, Nazma Begum, Mahmoodur Rahman, Nasreen Islam, Mohammad Quaiyum, Betty Kirkwood, Karen Edmond, Caitlin Shannon, Samuel Newton, Lisa Hurt, Fyezah Jehan, Imran Nisar, Atiya Hussain, Naila Nadeem, Muhammad Ilyas, Anita Zaidi, Sunil Sazawal, Saikat Deb, Arup Dutta, Usha Dhingra, Said Moh'd Ali, Davidson H Hamer, Katherine Ea Semrau, Marina Straszak-Suri, Caroline Grogan, Godfrey Bemba, Anne Cc Lee, Blair J Wylie, Alexander Manu, Sachiyo Yoshida, Rajiv Bahl
Objective: The objective of the Alliance for Maternal and Newborn Health Improvement (AMANHI) gestational age study is to develop and validate a programmatically feasible and simple approach to accurately assess gestational age of babies after they are born. The study will provide accurate, population-based rates of preterm birth in different settings and quantify the risks of neonatal mortality and morbidity by gestational age and birth weight in five South Asian and sub-Saharan African sites...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29162956/risk-assessment-at-11-14-week-antenatal-visit-a-tertiary-referral-center-experience-from-south-india
#8
Anusha Vellamkondu, Akhila Vasudeva, Rajeshwari G Bhat, Asha Kamath, Sapna V Amin, Lavanya Rai, Pratap Kumar
Background: Present study carried out in a tertiary referral hospital in South India attempts to determine the predictive value of integrated screening at 11-14-week antenatal visit. Objectives: To determine the detection rate of fetal abnormalities at 11-14 weeks and also to predict the placental dysfunction disorders based on early integrated evaluation. Method: Integrated screening performed on 440 women between 11 and 14 weeks, including detailed maternal history [medical history, bad obstetric history (BOH)], body mass index (BMI), mean arterial pressure (MAP), detailed ultrasound and maternal serum biochemistry as part of combined first-trimester screening for aneuploidy...
December 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29162955/diagnosis-and-management-of-cornual-pregnancies-from-2002-to-2015-at-a-tertiary-referral-centre-in-south-india-insights-from-introspection
#9
Vijaya B Bayyarapu, Sirisha R Gundabattula
Purpose: Interstitial, angular and rudimentary horn pregnancies have all been referred to as cornual pregnancies despite definite diagnostic criteria. Angular pregnancies can be followed up expectantly under close surveillance while interstitial and rudimentary horn pregnancies are terminated by medical or surgical methods. This study aimed to assess accuracy of ultrasound in the diagnosis of 'cornual pregnancy' and evaluate management. Methods: Data pertaining to clinical features, ultrasound findings and treatment modalities of the aforementioned conditions between January 2002 and December 2015 at a tertiary perinatal centre were retrieved from the medical records...
December 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29162486/cadmium-body-burden-and-pregnancy-induced-hypertension
#10
Hongxiu Liu, Wei Xia, Shunqing Xu, Bin Zhang, Bin Lu, Zheng Huang, Hongling Zhang, Yangqian Jiang, Wenyu Liu, Yang Peng, Xiaojie Sun, Yuanyuan Li
Previous studies provided a strong evidence of the association between environmental exposure to cadmium (Cd) and hypertension in the general population. However, the role of Cd in pregnancy-induced hypertension (PIH) remains unclear. A total of 5429 pregnant women was selected from a birth cohort in Wuhan, China to investigate the association between Cd exposure and risk of PIH. Among them, 199 (3.7%) women were diagnosed with PIH. The Cd concentrations in maternal urine collected at delivery were measured by inductively coupled plasma mass spectrometry...
November 18, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29162087/investigation-of-the-association-between-quality-of-life-and-depressive-symptoms-during-postpartum-period-a-correlational-study
#11
Maria Papamarkou, Pavlos Sarafis, Charis P Kaite, Maria Malliarou, Andreas Tsounis, Dimitris Niakas
BACKGROUND: The onset of a major depressive episode is experienced by a large number of women in the weeks or months following delivery. Postpartum depression may deem those women experiencing it incapable of taking care for themselves, their family and their infants, while at the same time it could negatively affect their quality of life. The present study assessed the quality of life of a sample of mothers in Greece, in order to investigate the association between postpartum depression and quality of life (QoL)...
November 21, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29162039/experiences-and-wishes-of-women-regarding-systemic-aspects-of-midwifery-care-in-germany-a-qualitative-study-with-focus-groups
#12
Elke Mattern, Susanne Lohmann, Gertrud M Ayerle
BACKGROUND: Knowledge of pregnant women's and mothers' viewpoints on midwifery care is crucial for its appropriate delivery and research. In Germany, comprehensive research to more fully understand women's needs in pregnancy, labour, birth and the postpartum period until weaning is lacking. International studies provide some knowledge of women's expectations, their choices, and subjective criteria indicating good midwifery care. METHODS: This study explores pregnant women's and mothers' experiences, needs and wishes regarding systemic aspects of midwifery care (access, availability, choices, model of midwifery care; maternity care in the healthcare system)...
November 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29161409/transfer-and-metabolism-of-cortisol-by-the-isolated-perfused-human-placenta
#13
Laura I Stirrat, Bram G Sengers, Jane E Norman, Natalie Z M Homer, Ruth Andrew, Rohan M Lewis, Rebecca M Reynolds
Context: Fetal overexposure to glucocorticoids in utero is associated with fetal growth restriction and is postulated to be a key mechanism linking suboptimal fetal growth with cardiovascular disease in later life. Objective: To develop a model to predict maternal-fetal glucocorticoid transfer. We hypothesised placental 11β-HSD2 would be the major rate-limiting step in maternal cortisol transfer to the fetus. Design: We used a deuterated cortisol tracer in the ex vivo placental perfusion model, in combination with computational modelling, to investigate the role of interconversion of cortisol and its inactive metabolite cortisone on transfer of cortisol from mother to fetus...
November 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29160571/sacral-neuromodulation-and-pregnancy-results-of-a-national-survey-carried-out-for-the-neuro-urology-committee-of-the-french-association-of-urology-afu
#14
Pauline Roulette, Evelyne Castel-Lacanal, Sylvain Sanson, Romain Caremel, Véronique Phé, Stéphane Bart, Franck Duchêne, Marianne De Sèze, Alexia Even, Andréa Manunta, Maria C Scheiber-Nogueira, Pascal Mouracade, Catherine-Marie Loche, Emmanuel Chartier-Kastler, Alain Ruffion, Gilles Karsenty, Xavier Gamé
AIMS: To assess the impact of sacral neuromodulation (SNM) on pregnancy and vice-versa, by identifying women who had received SNM for lower-urinary tract symptoms (LUTS) and had become pregnant. METHODS: A cross-sectional descriptive study was carried out based on responses to an on-line questionnaire sent to practitioners listed on the InterStim enCaptureTM National Registry. Questions were related to pre-pregnancy health and SNM efficacy, deactivation of the device, its impact on LUTS, childbirth, the infant, its reactivation and postpartum effectiveness...
November 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29159833/maternal-hypothyroidism-in-the-perinatal-period-and-childhood-asthma-in-the-offspring
#15
Xiaoqin Liu, Stine Linding Andersen, Jørn Olsen, Esben Agerbo, Vivi Schlünssen, Shyamali Chandrika Dharmage, Trine Munk-Olsen
BACKGROUND: There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in the present study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. METHODS: We conducted a population-based cohort study using Danish national registers. All liveborn singletons in Denmark from 1998 to 2007 were identified...
November 21, 2017: Allergy
https://www.readbyqxmd.com/read/29158370/ovarian-and-uterine-functions-in-female-survivors-of-childhood-cancers
#16
REVIEW
Ozgur Oktem, Samuel S Kim, Ugur Selek, Glenn Schatmann, Bulent Urman
Adult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29157955/development-of-a-goat-model-for-evaluation-of-withaferin-a-cervical-implants-for-the-treatment-of-cervical-intraepithelial-neoplasia
#17
Leslie C Sherwood, Farrukh Aqil, Manicka V Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay Srivastava, Inder P Singh, Scott Cambron, Martin O'Toole, Wendy Spencer, Lynn P Parker, Ramesh C Gupta
Cervical cancer is caused by human papillomavirus (HPV). The disease develops over many years through a series of precancerous lesions. Cervical cancer can be prevented by HPV-vaccination, screening and treatment of precancer before development of cervical cancer. The treatment of high-grade cervical dysplasia (CIN(2+)) has traditionally been by cervical conization. Surgical procedures are associated with increased risk of undesirable side effects including bleeding, infection, scarring (stenosis), infertility and complications in later pregnancies...
November 17, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29157455/identification-of-preterm-birth-based-on-rqa-analysis-of-electrohysterograms
#18
Marta Borowska, Ewelina Brzozowska, Paweł Kuć, Edward Oczeretko, Romuald Mosdorf, Piotr Laudański
BACKGROUND AND OBJECTIVE: Common methods for data analysis are mainly based on linear concepts, but in recent years nonlinear dynamics methods have been introduced. It is a well-known fact that In typical biological systems lack of stationarity and rather sudden changes of state are the properties distinguishing them from each other. There is an urgent need to better understand the mechanical activity of the myometrium (its contractility) to find a solution for preterm delivery problem, the largest cause of neonatal deaths and morbidity...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29157196/perinatal-outcomes-of-hypertensive-disorders-in-pregnancy-at-a-tertiary-hospital-in-ghana
#19
Kwame Adu-Bonsaffoh, Michael Y Ntumy, Samuel A Obed, Joseph D Seffah
BACKGROUND: Hypertensive disorders in pregnancy remain a major global health issue not only because of the associated high adverse maternal outcomes but there is a close accompaniment of significant perinatal morbidity and mortality especially in Sub-Saharan Africa (SSA). However, the perinatal burden of HDP in Ghana has not been explored. We conducted this study to determine the perinatal outcomes of HDP at a tertiary hospital in Ghana. METHODS: A cross-sectional study conducted between January to February 2013 at Korle Bu Teaching Hospital (KBTH) in Accra, Ghana...
November 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29157179/association-between-false-positive-torch-and-antiphospholipid-antibodies-in-healthy-pregnant-women
#20
S De Carolis, S Tabacco, F Rizzo, G Perrone, C Garufi, A Botta, S Salvi, P Benedetti Panici, A Lanzone
The present study investigated: (a) the presence of antiphospholipid antibodies and (b) the obstetric outcome in healthy pregnant women showing false-positive TORCH-Toxoplasmosis, Other: syphilis, varicella-zoster, Rubella, Cytomegalovirus (CMV), and Herpes infections-results. Data from 23 singleton healthy pregnancies with false-positive TORCH results were collected. Each woman was systematically screened for TORCH IgG and IgM during the pre-conception assessment and/or at the beginning of pregnancy. In the presence of IgM positivity, when indicated (CMV, toxoplasmosis, rubella, herpes simplex virus), IgG avidity was evaluated and, if possible, polymerase chain reaction was performed on an amniotic fluid sample in order to distinguish between primary infection or false positivity...
January 1, 2017: Lupus
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