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pregnancy and delivery

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https://www.readbyqxmd.com/read/29775476/maternal-asthma-is-associated-with-increased-risk-of-perinatal-mortality
#1
Mari Kemppainen, Anna-Maria Lahesmaa-Korpinen, Paula Kauppi, Martti Virtanen, Suvi M Virtanen, Riitta Karikoski, Mika Gissler, Turkka Kirjavainen
BACKGROUND: Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. OBJECTIVES: Our goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication. METHODS: The study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93...
2018: PloS One
https://www.readbyqxmd.com/read/29775434/births-final-data-for-2016
#2
Joyce A Martin, Brady E Hamilton, Michelle J K Osterman, Anne K Driscoll, Patrick Drake
This report presents 2016 data on U.S. births according to a wide variety of characteristics. Trends in fertility patterns and maternal and infant characteristics are described and interpreted.Descriptive tabulations of data reported on the birth certificates of the 3.95 million births that occurred in 2016 are presented. Data are presented for maternal age, live-birth order, race and Hispanic origin, marital status, tobacco use, prenatal care, source of payment for the delivery, method of delivery, gestational age, birthweight, and plurality...
January 2018: National Vital Statistics Reports
https://www.readbyqxmd.com/read/29774465/effect-of-inositol-stereoisomers-at-different-dosages-in-gestational-diabetes-an-open-label-parallel-randomized-controlled-trial
#3
Federica Fraticelli, Claudio Celentano, Isaia Al Zecca, Giacoma Di Vieste, Basilio Pintaudi, Marco Liberati, Marica Franzago, Marta Di Nicola, Ester Vitacolonna
AIMS: Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women. METHODS: Participants were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg D-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27...
May 17, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29774457/vitamin-d-as-a-follicular-marker-of-human-oocyte-quality-and-a-serum-marker-of-in-vitro-fertilization-outcome
#4
Przemysław Ciepiela, Antoni J Dulęba, Ewelina Kowaleczko, Kornel Chełstowski, Rafał Kurzawa
PURPOSE: This study investigated the relationship between the vitamin D [25(OH)D] level in individual follicles and oocyte developmental competence. METHODS: A prospective cohort study in a private infertility center. Infertile women (N = 198) scheduled for intracytoplasmic sperm injection (ICSI) and a single embryo transfer (SET) provided serum samples and 322 follicular fluid (FF) specimens, each from a single follicle on the day of oocyte retrieval. RESULTS: FFs corresponding to successfully fertilized oocytes (following ICSI) contained significantly lower 25(OH)D level compared with those that were not fertilized (28...
May 17, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29774445/pregnancy-complicated-by-influenza-a-ards-requiring-consecutive-vv-ecmo-treatment-with-successful-vaginal-delivery
#5
Peter Radsel, Vojka Gorjup, Anja Jazbec, Rihard Knafelj, Miha Lucovnik, Gorazd Kavsek, Lilijana Kornhauser Cerar, Marko Noc
A 29-year-old woman presented with influenza A ARDS at 23+0 weeks of gestation. Mechanical ventilation failed and VV-ECMO was started in a non-ECMO hospital. Transportation was performed on ECMO. Within 5 days ECMO weaning was successful. Fetal condition was stable, and decision to continue pregnancy was taken. However, second VV-ECMO was needed due to ventilator-associated pneumonia. At 25+6 weeks, the patient spontaneously delivered a neonate vaginally. Patient's condition improved, and ECMO could be removed 10 days postpartum...
May 17, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29774074/placenta-specific-drug-delivery-by-trophoblast-targeted-nanoparticles-in-mice
#6
Baozhen Zhang, Lunbo Tan, Yan Yu, Baobei Wang, Zhilong Chen, Jinyu Han, Mengxia Li, Jie Chen, Tianxia Xiao, Balamurali K Ambati, Lintao Cai, Qing Yang, Nihar R Nayak, Jian Zhang, Xiujun Fan
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum- infected erythrocytes (IEs) accumulate in the placenta by adhering to chondroitin sulfate A (CSA) on the surfaces of trophoblasts. Based on this principle, we have developed a method for targeted delivery of payloads to the placenta using a synthetic placental CSA-binding peptide (plCSA-BP) derived from VAR2CSA, a CSA-binding protein expressed on IEs...
2018: Theranostics
https://www.readbyqxmd.com/read/29773485/pregnancy-after-heterotopic-heart-transplant-removal
#7
S Churchill, L de Lloyd, H C Francis, H Wallis
Heterotopic heart transplants were introduced in 1974. The technique allows the patient's native heart to be preserved in situ, alongside the transplanted heterotopic donor heart (Newcomb et al., 2004). We present the case of a nulliparous woman who underwent heterotopic heart transplant in infancy, and subsequent explantation of the donor heart eleven years later, when her native heart function recovered. In adulthood the patient attended pre-pregnancy counselling and was awaiting cardiac magnetic resonance imaging when she presented pregnant at 6 weeks-of-gestation...
April 24, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29773310/maternal-concentrations-of-human-chorionic-gonadotrophin-in-very-early-ivf-pregnancies-and-duration-of-pregnancy-a-follow-up-study
#8
Tom G Tanbo, Manuela Zucknick, Anne Eskild
RESEARCH QUESTION: Are maternal concentrations of human chorionic gonadotropin (HCG) on a fixed day after embryo transfer associated with duration of pregnancy? DESIGN: A follow-up study of 1917 singleton pregnancies after IVF was performed. Embryos were cultured for 2 days and maternal HCG concentration quantified on day 12 after embryo transfer. Duration of pregnancy was obtained from the Medical Birth Registry of Norway. Association of HCG concentration (log2-transformed) with duration of pregnancy was estimated as hazard ratios (HR) with 95% confidence intervals (CI) by applying Cox regression proportional hazard models, where time to delivery for pregnancies shortened because of planned Caesarean delivery or induction of labour was treated as censored...
May 2, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29772945/the-efficiency-of-the-uterocervical-angle-in-the-prediction-of-second-trimester-pregnancy-terminations-in-multiparous-women
#9
Berna Aslan Cetin, Begum Aydogan Mathyk, Nadiye Koroglu, Gozde Demirezen, Gokce Turan, Gokhan Demirayak, Gokhan Yildirim
AIM: To show how uterocervical angles are used for the prediction of second-trimester pregnancy terminations in multiparous women. MATERIAL AND METHODS: A total of 148 multiparous singleton women in their second trimesters were enrolled in this prospective study. The intracervical Foley catheter was used for the induction of delivery. The cervical length (CL) and the uterocervical angle (UCA) were measured before the beginning of induction. The study population was subdivided into four groups; successful and failed terminations at the end of 24 and 48 h time frames...
May 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29772489/prevention-of-venous-thromboembolism-in-pregnant-patients-with-a-history-of-venous-thromboembolic-disease-a-retrospective-cohort-study
#10
Alejandro Lazo-Langner, Fatimah Al-Ani, Sarah Weisz, Camilla Rozanski, Martha Louzada, Judy Kovacs, Michael J Kovacs
BACKGROUND: Optimal prophylactic strategies in pregnant women with a history of venous thromboembolism (VTE) are unknown. PATIENTS AND METHODS: We conducted a retrospective cohort study of consecutive pregnant patients with a previous VTE history. Patients were followed until 6 weeks postpartum. Patients with a previous unprovoked event (including antepartum VTE) received antenatal prophylaxis, mostly with low dose low molecular weight heparin (LMWH). All patients received prophylaxis for six weeks after delivery...
May 5, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29772406/fertility-pregnancy-and-clinical-outcomes-after-uterine-arteriovenous-malformation-management
#11
Sophie Delplanque, Maela Le Lous, Maïa Proisy, Yolaine Joueidi, Estelle Bauville, Celine Rozel, Eugénie Beraud, Bertrand Bruneau, Jean Levêque, Vincent Lavoué, Krystel Nyangoh Timoh
STUDY OBJECTIVE: To evaluate fertility, pregnancy, and clinical outcomes after uterine arteriovenous malformation (UAVM) management. DESIGN: Single-center retrospective study from January 2000 to July 2017. (Canadian task force III). SETTING: One referral center. PATIENTS: Twenty-two patients with a UAVM diagnosed by Magnetic Resonance Angiography (MRA) or Computed Tomography (CT) angiography and managed by Expectant Management (EM) or Uterine Arterial Embolization (UAE) during the study period were included...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29772068/risk-factors-associated-with-preterm-delivery-and-low-delivery-weight-among-hiv-exposed-neonates-in-china
#12
Liming Wang, Hongxin Zhao, Weiping Cai, Jie Tao, Qingxia Zhao, Lijun Sun, Qingbo Fan, Athena P Kourtis, Colin Shepard, Fujie Zhang
OBJECTIVE: To examine the relationship between combination antiretroviral therapy (cART) and preterm delivery (PTD) or low delivery weight among pregnant Chinese women with HIV. METHODS: The present retrospective cross-sectional medical chart review enrolled pregnant women with HIV who delivered at five tertiary hospitals in China between January 1, 2009, and December 31, 2014. Generalized linear mixed modeling was used to explore PTD (<37 weeks of pregnancy) and low delivery weight (<2500 g) risk factors...
May 17, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29771679/acceptability-of-contraceptive-self-injection-with-dmpa-sc-among-adolescents-in-gulu-district-uganda
#13
Jane Cover, Jeanette Lim, Allen Namagembe, Justine Tumusiime, Jennifer Kidwell Drake, Carie Muntifering Cox
CONTEXT: In Uganda, an estimated one in four adolescent women have begun childbearing. Many adolescent pregnancies are unintended because of substantial barriers to contraceptive access. The injectable contraceptive is the most commonly used method in Uganda, and a new subcutaneous version offers the possibility of reducing access barriers by offering a self-injection option. However, more information about adolescent attitudes toward and interest in self-injection is needed. METHODS: In 2015, in-depth interviews were conducted with a purposive sample of 46 adolescent women aged 15-19 from rural and urban areas of Gulu District...
December 1, 2017: International Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29771604/association-of-the-placental-vegf-promoter-polymorphisms-and-vegf-mrna-expression-with-preeclampsia
#14
Farshid Keshavarzi, Mahnaz Shahrakipoor, Batool Teimoori, Minoo Yaghmaei, Mehrnaz Narooei-Nejad, Ava Rasooli, Saeedeh Salimi
BACKGROUND: Preeclampsia (PE), is a pregnancy-specific complication with the placental origin which associated with altered expression of angiogenic factors. Vascular Endothelial Growth Factor (VEGF), is a growth and hypoxia-induced factor which contributes to the regulation of various processes. The present study has investigated the association of the placental VEGF -634G/C (rs2010963), -1154G/A (rs1570360), and -2549 I/D (18bpindel) polymorphisms in the promoter region with VEGF mRNA expression in PE women and control group...
May 17, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29771477/serious-infections-in-rheumatoid-arthritis-offspring-exposed-to-tumour-necrosis-factor-%C3%AE-inhibitors-cohort-study
#15
Évelyne Vinet, Cristiano De Moura, Christian A Pineau, Michal Abrahamowicz, Jeffrey R Curtis, Sasha Bernatsky
OBJECTIVE: To evaluate the risk of serious infections in rheumatoid arthritis (RA) offspring exposed to tumour necrosis factor α inhibitors (TNFi) in the gestational period compared to unexposed RA offspring, as well as to children from the general population. METHODS: We used US claim data (2011-2015) to identify 2 989 RA offspring and a randomly selected group of 14 596 control children, matched ≥4:1 for maternal age, year of delivery, and state of residence...
May 17, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29770760/adherence-to-the-new-nordic-diet-during-pregnancy-and-subsequent-maternal-weight-development-a-study-conducted-in-the-norwegian-mother-and-child-cohort-study-moba
#16
Marianne Skreden, Elisabet R Hillesund, Andrew K Wills, Anne Lise Brantsæter, Elling Bere, Nina C Øverby
The rising prevalence of overweight and obesity is a worldwide public health challenge. Pregnancy and beyond is a potentially important window for future weight gain in women. We investigated associations between maternal adherence to the New Nordic diet (NND) during pregnancy and maternal BMI trajectories from delivery to 8 years post delivery. Data are from the Norwegian Mother and Child Cohort. Pregnant women from all of Norway were recruited between 1999 and 2008, and 55 056 are included in the present analysis...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29770432/automated-mandatory-bolus-versus-basal-infusion-for-maintenance-of-epidural-analgesia-in-labour
#17
REVIEW
Ban Leong Sng, Yanzhi Zeng, Nurun Nisa A de Souza, Wan Ling Leong, Ting Ting Oh, Fahad Javaid Siddiqui, Pryseley N Assam, Nian-Lin R Han, Edwin Sy Chan, Alex T Sia
BACKGROUND: Childbirth may cause the most severe pain some women experience in their lifetime. Epidural analgesia is an effective form of pain relief during labour and is considered to be the reference standard. Traditionally epidural analgesia has been delivered as a continuous infusion via a catheter in the epidural space, with or without the ability for the patient to supplement the analgesia received by activating a programmable pump to deliver additional top-up doses, known as patient-controlled epidural analgesia (PCEA)...
May 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29769490/comparison-of-outcome-of-eclamptic-patient-following-vaginal-delivery-versus-caeserian-delivery-by-spinal-anaesthesia
#18
M A Hossain, R K Karmoker, M S Rahman, H O Rashid, S H Khan, M A Rahman
Eclampsia is a common problem in pregnancy in Bangladesh. It is a severe form of preeclampsia which affects 5 to 7% of pregnancies is a significant cause of maternal & neonatal morbidity & mortality. Pre-eclampsia when complicated with generalized tonic-clonic convulsions and/or coma is called eclampsia. The term eclampsia is derived from a Greek word, meaning "like a flash of lightening". It may occur quite abruptly, without any warning manifestations. Eclampsia is a major cause of maternal mortality & morbidity as well as foetal loss worldwide, particularly in the third world...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769344/efficient-delivery-of-hcmv-t-cell-antigens-by-attenuated-sendai-virus-vectors
#19
Richard Kiener, Markus Fleischmann, Marian Alexander Wiegand, Niels A W Lemmermann, Christiane Schwegler, Christine Kaufmann, Angelique Renzaho, Simone Thomas, Eva Felder, Hans Helmut Niller, Benedikt Asbach, Ralf Wagner
Human Cytomegalovirus (HCMV) represents a major cause of clinical complications during pregnancy as well as immunosuppression and the licensing of a protective HCMV vaccine remains an unmet global need. Herein, we designed and validated novel Sendai virus (SeV) vectors delivering T cell immunogens IE-1 and pp65. To enhance vector safety, we used a replication-deficient strain (rdSeV) that infects target cells in a non-productive manner while retaining viral gene expression. In this study, we explored the impact that transduction with rdSeV has on human dendritic cells (DCs) by comparing it to the parental, replication-competent Sendai virus strain (rcSeV) as well as the poxvirus strain Modified Vaccinia Ankara (MVA)...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29769052/association-between-skilled-maternal-healthcare-and-postpartum-contraceptive-use-in-ethiopia
#20
Gizachew Assefa Tessema, Tensae Tadesse Mekonnen, Zelalem Birhanu Mengesha, Katherine Tumlinson
BACKGROUND: The postpartum period provides an important opportunity to address unmet need for contraception and reduce short birth intervals. This study aims to assess the association between skilled maternal healthcare and postpartum contraceptive use in Ethiopia. METHODS: Data for this analysis come from the 2011 to 2016 Ethiopian Demographic and Health Surveys (EDHS) and include nearly 5000 married women of reproductive age with a recent birth. Multivariate logistic regression was conducted to investigate the relationship between skilled maternal healthcare and postpartum contraceptive use...
May 16, 2018: BMC Pregnancy and Childbirth
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