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Faraoni D

Juliana Jendiroba Faraoni, Carmen Victoria Torres Toro, Laís Lopes Machado de Matos, Regina Guenka Palma-Dibb
OBJECTIVE: This study aims to evaluate how casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) associated with Nd:YAG or Diode laser affects dentin exposed to hydrochloric acid (HCl) with or without tooth brushing. DESIGN: One hundred and sixty human root dentin blocks were selected after they were initially eroded with liquid HCl (pH 1.2) 3x for one day. The blocks were divided into the following groups: G1- liquid HCl (HCl-l), G2- HCl-l + brushing, G3- gaseous HCl (HCl-g), and G4- HCl-g + brushing...
February 14, 2018: Archives of Oral Biology
A Godier, A Greinacher, D Faraoni, J H Levy, C M Samama
No abstract text is available yet for this article.
January 2018: Journal of Thrombosis and Haemostasis: JTH
James D O'Leary, Franklin Dexter, David Faraoni, Mark W Crawford
PURPOSE: Quantification of surgical procedures undertaken by hospitals is necessary for informing resource allocation and modelling healthcare services. Our objective was to quantify the incidence, similarity, and diversity of non-physiologically complex surgical procedures performed at pediatric specialist hospitals and other hospitals performing pediatric surgery. METHODS: We conducted a population-based cohort study of children aged 28 days to 18 yr who underwent surgery in the province of Ontario from 2007 to 2015 using healthcare administrative databases...
January 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
David Faraoni, Raquel Ferrandis Comes, William Geerts, Matthew D Wiles
: Although there are numerous publications addressing venous thromboembolism and its prevention in neurosurgery, there are relatively few high-quality studies to guide decisions regarding thromboprophylaxis. In patients undergoing craniotomy, we recommend that if intermittent pneumatic compression (IPC) is used, it should be applied before the surgical procedure or on admission (Grade 1C). In craniotomy patients at particularly high risk for venous thromboembolism, we suggest considering the initiation of mechanical thromboprophylaxis with IPC preoperatively with addition of low molecular weight heparin (LMWH) postoperatively when the risk of bleeding is presumed to be decreased (Grade 2C)...
February 2018: European Journal of Anaesthesiology
Sibylle A Kozek-Langenecker, Aamer B Ahmed, Arash Afshari, Pierre Albaladejo, Cesar Aldecoa, Guidrius Barauskas, Edoardo De Robertis, David Faraoni, Daniela C Filipescu, Dietmar Fries, Thorsten Haas, Matthias Jacob, Marcus D Lancé, Juan V L Pitarch, Susan Mallett, Jens Meier, Zsolt L Molnar, Niels Rahe-Meyer, Charles M Samama, Jakob Stensballe, Philippe J F Van der Linden, Anne J Wikkelsø, Patrick Wouters, Piet Wyffels, Kai Zacharowski
: The management of perioperative bleeding involves multiple assessments and strategies to ensure appropriate patient care. Initially, it is important to identify those patients with an increased risk of perioperative bleeding. Next, strategies should be employed to correct preoperative anaemia and to stabilise macrocirculation and microcirculation to optimise the patient's tolerance to bleeding. Finally, targeted interventions should be used to reduce intraoperative and postoperative bleeding, and so prevent subsequent morbidity and mortality...
June 2017: European Journal of Anaesthesiology
David Faraoni, James D O'Leary
No abstract text is available yet for this article.
April 2017: Minerva Anestesiologica
A Perez-Ferrer, J Vicente-Sanchez, M D Carceles-Baron, P Van der Linden, D Faraoni
BACKGROUND: Early clot amplitudes measured on thromboelastometry (ROTEM®) predict maximum clot firmness (MCF) in adults. In this multicentre, retrospective study, we aimed to confirm the suspected relationship between early ROTEM® variables and MCF, in children undergoing cardiac or non-cardiac surgery. METHODS: 4762 ROTEM® tests (e.g. EXTEM, INTEM, FIBTEM, APTEM, and HEPTEM) performed in children undergoing cardiac or non-cardiac surgery at three University hospitals between January 2011 and June 2014 were reviewed...
December 2015: British Journal of Anaesthesia
D Faraoni, J A DiNardo
No abstract text is available yet for this article.
April 2015: Acta Anaesthesiologica Scandinavica
D Faraoni, J A Dinardo
No abstract text is available yet for this article.
July 2015: Minerva Anestesiologica
D Faraoni, C Carlier, C M Samama, J H Levy, A S Ducloy-Bouthors
OBJECTIVE(S): Assess the efficacy and safety of tranexamic acid administration for the prevention and/or the treatment of postpartum haemorrhage. STUDY DESIGN: Systematic review with meta-analysis. MATERIAL AND METHODS: Systematic review of the literature with the aim of identifying prospective, randomised, controlled trials that assessed the effect of tranexamic acid on peripartum blood loss and transfusion requirement in three clinical contexts: (i) prevention of post-partum haemorrhage in case of elective caesarean section, (ii) prevention of post-partum haemorrhage in case of vaginal delivery, (iii) treatment of post-partum haemorrhage...
November 2014: Annales Françaises D'anesthèsie et de Rèanimation
David Faraoni, Christophe Cacheux, Caroline Van Aelbrouck, Brigitte E Ickx, Luc Barvais, Jerrold H Levy
BACKGROUND: Tranexamic acid is used to decrease bleeding and transfusions during cardiac surgery. However, dosing based on pharmacokinetic data to optimally inhibit fibrinolysis is unknown. With increasing concerns regarding seizures associated with higher doses, lower dosing schemes may be important. OBJECTIVE: To determine the effect of two dosing schemes compared with placebo on fibrinolysis and clinical outcomes. DESIGN: A double-blind, randomised, controlled, pilot trial...
September 2014: European Journal of Anaesthesiology
V Savan, A Willems, D Faraoni, P Van der Linden
BACKGROUND: Postoperative bleeding and blood product transfusion increase morbidity, mortality, and costs after cardiac surgery. However, factors that could accurately predict bleeding have not been well studied in children undergoing cardiac surgery. This study aims at determining factors that could be used to predict postoperative bleeding in this paediatric population. METHODS: We included 182 children undergoing congenital heart surgery. Significant bleeding was defined as a blood loss that exceeds 10% of total blood volume within the first 6 postoperative hours...
April 2014: British Journal of Anaesthesia
D Faraoni, P Van Der Linden
Every year, more than a million people die as a result of trauma. This huge mortality could be partially explained by the development of an acute traumatic coagulopathy, present in a large part of all major trauma patients, soon after injury, which contributes to ongoing hemorrhage. The coagulopathy induced by trauma is independently associated with mortality, increased transfusion requirements, multiple organ dysfunction, infections, increased intensive care unit (ICU) length of stay, and costs. The pathophysiological mechanisms implicated in this acute traumatic coagulopathy are complexes and lead to generate a vicious circle leading to the activation of different pathways: thrombin generation, plasmin generation, inflammation activation...
October 2014: Minerva Anestesiologica
Jerrold H Levy, David Faraoni, Jenna L Spring, James D Douketis, Charles M Samama
Managing patients in the perioperative setting receiving novel oral anticoagulation agents for thromboprophylaxis or stroke prevention with atrial fibrillation is an important consideration for clinicians. The novel oral anticoagulation agents include direct Factor Xa inhibitors rivaroxaban and apixaban, and the direct thrombin inhibitor dabigatran. In elective surgery, discontinuing their use is important, but renal function must also be considered because elimination is highly dependent on renal elimination...
June 2013: Anesthesiology
Anna Tarantini, Alessandra Faraoni, Francesca Menchini, Paolo Lanzetta
Purpose. To describe a patient who developed bilateral, simultaneous nonarteritic anterior ischemic optic neuropathy (NAION) after ingestion of Sildenafil citrate (Viagra) for erectile dysfunction. Methods. Observational case report. Results. A 60-year-old diabetic man noted sudden decrease of vision in both eyes 16 hours after his third consecutive 50 mg daily Sildenafil ingestion. A diagnosis of bilateral NAION was made and he was treated for three days with methylprednisolone 1 g/d intravenously, followed by oral prednisone 75 mg/d...
2012: Case Reports in Medicine
Joyce James, Bruce Ruggeri, Robert C Armstrong, Martin W Rowbottom, Susan Jones-Bolin, Ruwanthi N Gunawardane, Pawel Dobrzanski, Michael F Gardner, Hugh Zhao, Merryl D Cramer, Kathryn Hunter, Ronald R Nepomuceno, Mangeng Cheng, Dana Gitnick, Mehran Yazdanian, Darren E Insko, Mark A Ator, Julius L Apuy, Raffaella Faraoni, Bruce D Dorsey, Michael Williams, Shripad S Bhagwat, Mark W Holladay
Mutations in the BRAF gene have been identified in approximately 7% of cancers, including 60% to 70% of melanomas, 29% to 83% of papillary thyroid carcinomas, 4% to 16% colorectal cancers, and a lesser extent in serous ovarian and non-small cell lung cancers. The V600E mutation is found in the vast majority of cases and is an activating mutation, conferring transforming and immortalization potential to cells. CEP-32496 is a potent BRAF inhibitor in an in vitro binding assay for mutated BRAF(V600E) (K(d) BRAF(V600E) = 14 nmol/L) and in a mitogen-activated protein (MAP)/extracellular signal-regulated (ER) kinase (MEK) phosphorylation (pMEK) inhibition assay in human melanoma (A375) and colorectal cancer (Colo-205) cell lines (IC(50) = 78 and 60 nmol/L)...
April 2012: Molecular Cancer Therapeutics
Martin W Rowbottom, Raffaella Faraoni, Qi Chao, Brian T Campbell, Andiliy G Lai, Eduardo Setti, Maiko Ezawa, Kelly G Sprankle, Sunny Abraham, Lan Tran, Brian Struss, Michael Gibney, Robert C Armstrong, Ruwanthi N Gunawardane, Ronald R Nepomuceno, Ianina Valenta, Helen Hua, Michael F Gardner, Merryl D Cramer, Dana Gitnick, Darren E Insko, Julius L Apuy, Susan Jones-Bolin, Arup K Ghose, Torsten Herbertz, Mark A Ator, Bruce D Dorsey, Bruce Ruggeri, Michael Williams, Shripad Bhagwat, Joyce James, Mark W Holladay
The Ras/RAF/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway plays a central role in the regulation of cell growth, differentiation, and survival. Expression of mutant BRAF(V600E) results in constitutive activation of the MAPK pathway, which can lead to uncontrolled cellular growth. Herein, we describe an SAR optimization campaign around a series of quinazoline derived BRAF(V600E) inhibitors. In particular, the bioisosteric replacement of a metabolically sensitive tert-butyl group with fluorinated alkyl moieties is described...
February 9, 2012: Journal of Medicinal Chemistry
Mark W Holladay, Brian T Campbell, Martin W Rowbottom, Qi Chao, Kelly G Sprankle, Andiliy G Lai, Sunny Abraham, Eduardo Setti, Raffaella Faraoni, Lan Tran, Robert C Armstrong, Ruwanthi N Gunawardane, Michael F Gardner, Merryl D Cramer, Dana Gitnick, Mark A Ator, Bruce D Dorsey, Bruce R Ruggeri, Michael Williams, Shripad S Bhagwat, Joyce James
Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride) exhibits good pharmacokinetic properties in rat and mouse and is efficacious in a mouse tumor xenograft model following oral dosing.
September 15, 2011: Bioorganic & Medicinal Chemistry Letters
K C Nicolaou, Adrian Ortiz, Hongjun Zhang, Philippe Dagneau, Andreas Lanver, Michael P Jennings, Stellios Arseniyadis, Raffaella Faraoni, Dimitrios E Lizos
The total synthesis of the originally assigned structure of vannusal B (2) and its diastereomer (d-2) are described. Initial forays into these structures with model systems revealed the viability of a metathesis-based approach and a SmI(2)-mediated strategy for the key cyclization to forge the central region of the molecule, ring C. The former approach was abandoned in favor of the latter when more functionalized substrates failed to enter the cyclization process. The successful, devised convergent strategy based on the SmI(2)-mediated ring closure utilized vinyl iodide (-)-26 and aldehyde fragment (+/-)-86 as key building blocks, whose lithium-mediated coupling led to isomeric coupling products (+)-87 and (-)-88 (as shown in Scheme 17 in the article)...
May 26, 2010: Journal of the American Chemical Society
S Altieri, M Balzi, S Bortolussi, P Bruschi, L Ciani, A M Clerici, P Faraoni, C Ferrari, M A Gadan, L Panza, D Pietrangeli, G Ricciardi, S Ristori
Boron neutron capture therapy (BNCT) is an anticancer therapy based on the incorporation of (10)B in tumors, followed by neutron irradiation. Recently, the synthesis and delivery of new boronated compounds have been recognized as some of the main challenges in BNCT application. Here, we report on the use of liposomes as carriers for BNCT active compounds. Two carborane derivatives, i.e., o-closocarboranyl beta-lactoside (LCOB) and 1-methyl-o-closocarboranyl-2-hexylthioporphyrazine (H(2)PzCOB), were loaded into liposomes bearing different surface charges...
December 10, 2009: Journal of Medicinal Chemistry
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