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thrombomodulin

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https://www.readbyqxmd.com/read/28739377/blood-hemostatic-changes-during-an-ultraendurance-road-cycling-event-in-a-hot-environment
#1
Brian R Kupchak, Josh B Kazman, Jakob L Vingren, Danielle E Levitt, Elaine C Lee, Keith H Williamson, Lawrence E Armstrong, Patricia A Deuster
OBJECTIVE: This study aims to examine blood hemostatic responses to completing a 164-km road cycling event in a hot environment. METHODS: Thirty-seven subjects (28 men and 9 women; 51.8±9.5 [mean±SD] y) completed the ride in 6.6±1.1 hours. Anthropometrics (height, body mass [taken also during morning of the ride], percent body fat [%]) were collected the day before the ride. Blood samples were collected on the morning of the ride (PRE) and immediately after (IP) the subject completed the ride...
July 21, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28739343/inhibition-of-cell-apoptosis-and-amelioration-of-pulmonary-fibrosis-by-thrombomodulin
#2
Kentaro Fujiwara, Tetsu Kobayashi, Hajime Fujimoto, Hiroki Nakahara, Corina N D'Alessandro-Gabazza, Josephine A Hinneh, Yoshinori Takahashi, Taro Yasuma, Kota Nishihama, Masaaki Toda, Masahiro Kajiki, Yoshiyuki Takei, Osamu Taguchi, Esteban C Gabazza
Pulmonary fibrosis is the terminal stage of a group of idiopathic interstitial pneumonias, of which idiopathic pulmonary fibrosis is the most frequent and fatal form. Recent studies have shown that recombinant human thrombomodulin improves exacerbation and clinical outcome of idiopathic pulmonary fibrosis, but the mechanism remains unknown. This study evaluated the mechanistic pathways of the inhibitory activity of recombinant human thrombomodulin in pulmonary fibrosis. Transgenic mice overexpressing human transforming growth factor β1 that develop spontaneously pulmonary fibrosis and wild-type mice treated with bleomycin were used as model of lung fibrosis...
July 21, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28737512/thrombin-promotes-diet-induced-obesity-through-fibrin-driven-inflammation
#3
Anna K Kopec, Sara R Abrahams, Sherry Thornton, Joseph S Palumbo, Eric S Mullins, Senad Divanovic, Hartmut Weiler, A Phillip Owens, Nigel Mackman, Ashley Goss, Joanne van Ryn, James P Luyendyk, Matthew J Flick
Obesity promotes a chronic inflammatory and hypercoagulable state that drives cardiovascular disease, type 2 diabetes, fatty liver disease, and several cancers. Elevated thrombin activity underlies obesity-linked thromboembolic events, but the mechanistic links between the thrombin/fibrin(ogen) axis and obesity-associated pathologies are incompletely understood. In this work, immunohistochemical studies identified extravascular fibrin deposits within white adipose tissue and liver as distinct features of mice fed a high-fat diet (HFD) as well as obese patients...
July 24, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28733353/use-of-proteomics-to-investigate-kidney-function-decline-over-5-years
#4
Axel C Carlsson, Erik Ingelsson, Johan Sundström, Juan Jesus Carrero, Stefan Gustafsson, Tobias Feldreich, Markus Stenemo, Anders Larsson, Lars Lind, Johan Ärnlöv
BACKGROUND AND OBJECTIVES: Using a discovery/replication approach, we investigated associations between a multiplex panel of 80 circulating proteins associated with cardiovascular pathology or inflammation, and eGFR decline per year and CKD incidence. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used two cohorts, the Prospective Investigation of the Vasculature in Uppsala Seniors Study (PIVUS; n=687, mean age of 70 years, 51% women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n=360 men, mean age of 78 years), with 5-year follow-up data on eGFR...
July 21, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28732053/dysregulation-of-pulmonary-endothelial-protein-c-receptor-and-thrombomodulin-in-severe-falciparum-malaria-associated-ards-relevant-to-hemozoin
#5
Sitang Maknitikul, Natthanej Luplertlop, Georges E R Grau, Sumate Ampawong
To investigate the role of the protein C system, endothelial protein C receptor (EPCR) and thrombomodulin (TM) in the pathogenesis of malaria-associated acute respiratory distress syndrome (ARDS) in relation to hemozoin and proinflammatory cytokines-induced type II pneumocyte injury and -aggravated pulmonary resolution. A total of 29 left-over lung specimens that were obtained from patients who died from severe falciparum malaria were examined. Histopathological, immunohistochemical and electron microscopic analyses revealed that ARDS coexisted with pulmonary edema and systemic bleeding; the severity was dependent on the level of hemozoin deposition in the lung and internal alveolar hemorrhaging...
2017: PloS One
https://www.readbyqxmd.com/read/28717074/effect-of-thrombomodulin-alfa-on-disseminated-intravascular-coagulation-in-patients-with-lung-cancer
#6
Kentaro Nakano, Kumiya Sugiyama, Hideyuki Satoh, Hajime Arifuku, Takayoshi Fujimatsu, Naruo Yoshida, Hiroyoshi Watanabe, Shingo Tokita, Tomoshige Wakayama, Masamitsu Tatewaki, Ryosuke Souma, Hiroyuki Masuda, Kenya Koyama, Hirokuni Hirata, Yasutsugu Fukushima
Objective The mortality rate due to disseminated intravascular coagulation (DIC) is higher in patients with lung cancer than in those without. We examined the effect of treatment with thrombomodulin alfa (TM-α) for DIC in lung cancer patients. Methods Subjects were 57 patients with DIC (43 men, 14 women; mean age, 71.7 years), comprising 31 with lung cancer and 26 without. DIC patients with or without lung cancer did not differ significantly in their background characteristics. Results No significant difference was noted in the mortality rate between patients with lung cancer (61...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28711778/the-efficacy-and-associated-bleeding-complications-of-recombinant-antithrombin-supplementation-among-intensive-care-unit-patients
#7
Hiroyuki Koami, Yuichiro Sakamoto, Ryota Sakurai, Miho Ohta, Hisashi Imahase, Mayuko Yahata, Mitsuru Umeka, Toru Miike, Futoshi Nagashima, Takashi Iwamura, Kosuke Chris Yamada, Satoshi Inoue
INTRODUCTION: The aim of this study was to evaluate the efficacy and complications of recombinant antithrombin (rAT) supplementation for adult patients with disseminated intravascular coagulation (DIC) compared with conventional plasma derived AT (pAT) treatment in the intensive care unit. MATERIALS AND METHODS: This study was performed in a single national university hospital in Japan. Adult patients from April 2015 to March 2016 with DIC were divided into two groups based on the type of AT agent used: the pAT group (n=24) and the rAT group (n=21)...
July 3, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28710034/association-of-thrombomodulin-c-1418c-t-polymorphism-and-venous-thromboembolism
#8
Bei Hu, Qing-Yun Wang, Liang Tang, Yu Hu
OBJECTIVES: To investigate the association between thrombomodulin c.1418C>T polymorphism and venous thrombosis. METHODS: Systematic searches of Pubmed, EMBASE, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, the VIP Database and WANFANG Database were performed. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Subgroup analysis was conducted to seek for potential sources of heterogeneity...
July 11, 2017: Gene
https://www.readbyqxmd.com/read/28706977/acute-rejection-after-kidney-transplantation-associates-with-circulating-micrornas-and-vascular-injury
#9
Roel Bijkerk, Barend W Florijn, Meriem Khairoun, Jacques M G J Duijs, Gurbey Ocak, Aiko P J de Vries, Alexander F Schaapherder, Marko J K Mallat, Johan W de Fijter, Ton J Rabelink, Anton Jan van Zonneveld, Marlies E J Reinders
BACKGROUND: Acute rejection (AR) of kidney transplants is associated with the loss of endothelial integrity, microvascular rarefaction and, ultimately, graft dysfunction. Circulating angiogenic microRNAs (miRNAs) may serve as markers for microvascular injury. Here, we investigated the short- and long-term effects of AR after kidney transplantation on systemic vascular injury and the associated circulating miRNA profile. METHODS: Systemic vascular injury was determined by measuring capillary tortuosity and density within the oral mucosa as well as by assessing circulating levels of angiopoietin-2/angiopoietin-1 ratio, vascular endothelial growth factor and soluble thrombomodulin...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28704795/endocan-concentrations-in-postmortem-serum-vitreous-humor-and-urine-in-victims-of-lethal-hypothermia
#10
Emilienne Descloux, Marc Augsburger, Grzegorz Teresiński, Petr Hejna, Eric Grouzmann, Maria Pia Scarpelli, Tania Hervet, Cristian Palmiere
Endocan is a soluble molecule secreted from vascular endothelial cells of various organs. Its exact function in humans remains to be elucidated, though it has been postulated that increased tissue expression or serum levels of this molecule may be an indicator of endothelial activation and neovascularization. In the realm of forensic pathology, studies pertaining to endothelial activation following exposure to cold exclusively focused on thrombomodulin, a transmembrane protein specific to endothelial cells...
July 4, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28694021/recombinant-and-chemo-bio-orthogonal-synthesis-of-liposomal-thrombomodulin-and-its-antithrombotic-activity
#11
Lin Wang, Rui Jiang, Yang Liu, Maosheng Cheng, Qingyu Wu, Xue-Long Sun
Thrombomodulin (TM) is an endothelial cell membrane protein that acts as a major cofactor in the protein C anticoagulant pathway. The EGF-like domains 4-6 of TM (TM456) are essential for PC activation. In this study, we proposed a liposomal recombinant TM conjugate to mimic the membrane TM structure and its anticoagulant activity. First, a DSPE-PEG2000-TM456 was successfully synthesized by site-specific conjugation of azido-TM456 with DSPE-PEG2000-DBCO via copper-free click chemistry quantitatively. Then, liposome-TM456 was fabricated via direct liposome formation with the DSPE-PEG2000-TM456 and other lipids...
July 7, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28692110/plasma-carboxypeptidase-u-cpu-cpb2-tafia-generation-during-in-vitro-clot-lysis-and-its-interplay-between-coagulation-and-fibrinolysis
#12
Dorien Leenaerts, Jef Aernouts, Pieter Van Der Veken, Yani Sim, Anne-Marie Lambeir, Dirk Hendriks
Carboxypeptidase U (CPU, CPB2, TAFIa) is a basic carboxypeptidase that is able to attenuate fibrinolysis. The inactive precursor procarboxypeptidase U is converted to its active form by thrombin, the thrombin-thrombomodulin complex or plasmin. The aim of this study was to investigate and characterise the time course of CPU generation in healthy individuals. In plasma of 29 healthy volunteers, CPU generation was monitored during in vitro clot lysis. CPU activity was measured by means of an enzymatic assay that uses the specific substrate Bz-o-cyano-Phe-Arg...
July 6, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28690216/-plasma-level-of-apelin-and-carotid-atherosclerosis-in-maintenance-hemodialysis-patients
#13
Rong Tang, Ruiling Wang, Xiang Ao, Xiaomiao Cheng
To determine the plasma level of apelin in patients of maintenance hemodialysis (MHD) and to explore the relationship between apelin level and carotid atherosclerosis (AS) in MHD patients.
 Methods: A total of 92 MHD patients and 36 sex- and age-matched healthy subjects were enrolled in this study. The plasma level of apelin was evaluated by radiation immunoassay; serum endothelial injury markers including thrombomodulin, von Willebrand factor (vWF), and CD146, and inflammatory factors including high sensitive C-reactive protein (hsCRP), IL-6 and TNF-α were determined by ELISA...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28687251/associations-between-acute-gvhd-related-biomarkers-and-endothelial-cell-activation-after-allogeneic-hematopoietic-stem-cell-transplantation
#14
Shosaku Nomura, Kazuyoshi Ishii, Shinya Fujita, Aya Nakaya, Atsushi Satake, Tomoki Ito
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) can cause serious transplant-related complications such as graft-versus-host disease (GVHD). Acute GVHD (aGVHD) has been diagnosed by clinical manifestations, laboratory data and pathological effects until now, but recently the discovery of specific biomarkers such as suppression of tumorigenicity 2 (ST2), elafin and regenerating islet-derived 3α (REG3α) is challenging this approach. METHODS: We investigated the expression of aGVHD-related markers (regulated on activation normal T-cell expressed and secretes: RANTES, elafin, REG3α and ST2) and endothelial cell activation markers (soluble vascular cell adhesion molecule: sVCAM-1 and plasminogen activator inhibitor: PAI-1) in patients undergoing allogeneic HSCT...
July 4, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28671670/multimerin-2-is-a-ligand-for-group-14-family-c-type-lectins-clec14a-cd93-and-cd248-spanning-the-endothelial-pericyte-interface
#15
K A Khan, A J Naylor, A Khan, P J Noy, M Mambretti, P Lodhia, J Athwal, A Korzystka, C D Buckley, B E Willcox, F Mohammed, R Bicknell
The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pericytes. Multimerin-2 (MMRN2) is a unique endothelial specific extracellular matrix protein that has been implicated in angiogenesis and tumour progression. We show that the group 14 C-type lectins CLEC14A, CD93 and CD248 directly bind to MMRN2 and only thrombomodulin of the family does not...
July 3, 2017: Oncogene
https://www.readbyqxmd.com/read/28669410/thrombin-activatable-fibrinolysis-inhibitor-tafi-a-possible-link-between-coagulation-and-complement-activation-in-the-antiphospholipid-syndrome-aps
#16
Giorgia Grosso, Anna Vikerfors, Barry Woodhams, Mariette Adam, Katarina Bremme, Margareta Holmström, Anna Ågren, Anna Eelde, Maria Bruzelius, Elisabet Svenungsson, Aleksandra Antovic
BACKGROUND: Thrombosis and complement activation are pathogenic features of antiphospholipid syndrome (APS). Their molecular link is Plasma carboxypeptidase-B, also known as thrombin activatable fibrinolysis inhibitor (TAFIa), which plays a dual role: anti-fibrinolytic, by cleaving carboxyl-terminal lysine residues from partially degraded fibrin, and anti-inflammatory, by downregulating complement anaphylatoxins C3a and C5a. AIM: To investigate the levels of TAFI (proenzyme) and TAFIa (active enzyme) in relation to complement activation, fibrin clot permeability and fibrinolytic function in clinical and immunological subsets of 52 APS patients and 15 controls...
June 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28664473/comparison-of-the-ameliorative-effects-of-qingfei-tongluo-formula-and-azithromycin-on-mycoplasma-pneumoniae-pneumonia
#17
Zhen Xiao, Yonghong Jiang, Xuan Gao, Shuzhu Lin, Yan Lin, Xiuxiu Liu, Dan Tan, Zhiyan Jiang
Mycoplasma pneumoniae pneumonia (MPP) is a common disease in children. Qingfei Tongluo formula (QTF) has been used for the treatment of MPP clinically, but the therapeutic effect remains unclear compared to conventional treatments with Western medicines. Therefore, the aim of this study was to assess changes in the expression levels of relevant factors associated with microcirculation after MPP and to compare the therapeutic effect of QTF with that of azithromycin (AZM) on experimental mice with MPP. A total of 174 children admitted with clinical diagnoses of pneumonia (80 MPP and 94 non-MPP) were used to identify differences in the expression patterns of factors in the microcirculation using an enzyme-linked immunosorbent assay...
June 29, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28651248/evaluation-of-plasma-thrombomodulin-in-patients-with-coronary-slow-flow
#18
Yong Wang, Peng-Yu Jia, Bao-Jun Chen, Yan Chen, Hang Yu, Yao Yu, Hui-Min Yang, Da-Lin Jia, Chun-Yan Ma
BACKGROUND: It has been reported that coronary slow flow (CSF) is associated with acute myocardial infarction, ventricular tachycardia, ventricular fibrillation, and even sudden cardiac death. Although studies concerning the etiopathogenesis of CSF are scarce, diffuse atherosclerosis and endothelial dysfunction are thought to play important roles. It has been suggested that a high plasma thrombomodulin (TM) level seems to play an important role in the pathogenesis of atherosclerosis and endothelial dysfunction...
June 27, 2017: Cardiology
https://www.readbyqxmd.com/read/28650448/transplant-associated-thrombotic-microangiopathy-is-an-endothelial-complication-associated-with-refractoriness-of-acute-gvhd
#19
M Zeisbrich, N Becker, A Benner, A Radujkovic, K Schmitt, J Beimler, A D Ho, M Zeier, P Dreger, T Luft
There is increasing evidence that endothelial dysfunction is involved in refractoriness of acute GvHD (aGvHD). Here we investigated the hypothesis that another endothelial complication, transplant-associated thrombotic microangiopathy (TMA), contributes to the pathogenesis of aGvHD refractoriness. TMA was retrospectively assessed in 771 patients after allogeneic stem cell transplantation (alloSCT). Incidences of TMA and refractory aGvHD were correlated with biomarkers of endothelial damage obtained before alloSCT for patients receiving or not receiving statin-based endothelial prophylaxis (SEP)...
June 26, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28645823/recombinant-human-soluble-thrombomodulin-prevents-acute-lung-injury-in-a-rat-cardiopulmonary-bypass-model
#20
Shingo Hirao, Kenji Minakata, Hidetoshi Masumoto, Kazuhiro Yamazaki, Tadashi Ikeda, Kenji Minatoya, Ryuzo Sakata
BACKGROUND: Cardiopulmonary bypass (CPB) may induce systemic inflammatory responses causing acute lung injury. Recombinant human soluble thrombomodulin (rTM) is reported to attenuate the secretion of inflammatory cytokines and the high-mobility group box 1 (HMGB1) protein, which is critical in controlling systemic inflammation and apoptosis. We investigated the protective effects of rTM on CPB-induced lung injury in a rat model. METHODS: Eighteen male Sprague-Dawley rats were divided into 3 groups: sham, control (CPB alone), and rTM (CPB + rTM)...
May 30, 2017: Journal of Thoracic and Cardiovascular Surgery
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