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https://www.readbyqxmd.com/read/29444550/non-invasive-assessment-of-kidney-allograft-fibrosis-with-shear-wave-elastography-a-radiological-pathological-correlation-analysis
#1
Maggie Km Ma, Helen Kw Law, Kin Sun Tse, Kwok Wah Chan, Gary Cw Chan, Desmond Yh Yap, Maggie My Mok, Lorraine Py Kwan, Sydney Cw Tang, Bo Ying Choy, Tak Mao Chan
OBJECTIVES: To evaluate the use of shear wave elastography in assessment of kidney allograft tubulointerstitial fibrosis. METHODS: Shear wave elastography assessment was carried out by two independent operators in kidney transplant recipients who underwent allograft biopsy for clinical indications (i.e. rising creatinine >15% or proteinuria >1 g/day). Allograft biopsies were interpreted by the same pathologist according to the 2013 Banff Classification. RESULTS: A total of 40 elastography scans were carried out (median creatinine 172...
February 14, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29436677/-retracted-apogossypolone-inhibits-the-proliferation-of-lncap-cells-in%C3%A2-vitro-and-in%C3%A2-vivo
#2
Xianqing Zhang, Xingbin Hu, Shijie Mu, Yonghua Zhan, Qunxing An, Zhixin Liu, Xiaofeng Huang
An interested reader drew to the attention of the Editorial Board of Molecular Medicine Reports that certain data in the above paper had already been published in a previous study featuring several of the same authors [Zhang XQ, Huang XF, Hu XB, Zhan YH, An QX, Yang SM, Xia AJ, Yi J, Chen R, Mu SJ and Wu DC: "Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro". Asian J Androl 12: 697-708, 2010]. Specifically, Figs...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29412478/relativistic-heavy-atom-effect-on-13-c-nmr-chemical-shifts-initiated-by-adjacent-multiple-chalcogens
#3
Yu Yu Rusakov, I L Rusaskova
In this paper we have investigated the cumulative peculiarity of the "heavy atom on light atom" effect on the 13 C NMR chemical shifts, initiated by the adjacent chalcogens. For this purpose, the most accurate hybrid computational scheme for the calculation of chemical shifts of carbon nuclei, directly bonded with several heavy chalcogens, is introduced and attested on the representative series of molecules. The best hybrid scheme combines the nonrelativistic coupled cluster-based approach with the different types of corrections, including vibrational, solvent and relativistic...
February 7, 2018: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29409498/dna-methylome-profiling-at-single-base-resolution-through-bisulfite-sequencing-of-5mc-immunoprecipitated-dna
#4
Zhen Jia, Yueyi Shi, Lei Zhang, Yipeng Ren, Tong Wang, Lejun Xing, Baorong Zhang, Guolan Gao, Rongfa Bu
BACKGROUND: Detection of DNA methylome at single-base resolution is a significant challenge but promises to shed considerable light on human disease etiology. Current technologies could not detect DNA methylation genome-wide at single-base resolution with small amount of sequencing data and could not avoid detecting the methylation of repetitive elements which are considered as "junk DNA". METHODS: In this study, we have developed a novel DNA methylome profiling technology named MB-seq with its ability to identify genome-wide 5mC and quantify DNA methylation levels by introduced an assistant adapter AluI-linker This linker can be ligated to sonicated DNA and then be digested after the bisulfite treatment and amplification, which has no effect of MeDIP enrichment...
February 6, 2018: BMC Biotechnology
https://www.readbyqxmd.com/read/29402381/mitochondrial-coq-deficiency-is-a-common-driver-of-mitochondrial-oxidants-and-insulin-resistance
#5
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean Yh Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This defect was observed in a range of in vitro insulin resistance models and adipose tissue from insulin-resistant humans and was concomitant with lower expression of mevalonate/CoQ biosynthesis pathway proteins in most models. Pharmacologic or genetic manipulations that decreased mitochondrial CoQ triggered mitochondrial oxidants and insulin resistance while CoQ supplementation in either insulin-resistant cell models or mice restored normal insulin sensitivity...
February 6, 2018: ELife
https://www.readbyqxmd.com/read/29400564/rejoinder
#6
Scott Yh Kim, James Flory, Clare Relton
No abstract text is available yet for this article.
February 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29376887/hypothalamic-loss-of-snord116-recapitulates-the-hyperphagia-of-prader-willi-syndrome
#7
Joseph Polex-Wolf, Brian Yh Lam, Rachel Larder, John Tadross, Debra Rimmington, Fàtima Bosch, Verónica Jiménez Cenzano, Eduard Ayuso, Marcella Kl Ma, Kara Rainbow, Anthony P Coll, Stephen O'Rahilly, Giles Sh Yeo
Profound hyperphagia is a major disabling feature of Prader-Willi syndrome (PWS). Characterization of the mechanisms that underlie PWS-associated hyperphagia has been slowed by the paucity of animal models with increased food intake or obesity. Mice with a microdeletion encompassing the Snord116 cluster of noncoding RNAs encoded within the Prader-Willi minimal deletion critical region have previously been reported to show growth retardation and hyperphagia. Here, consistent with previous reports, we observed growth retardation in Snord116+/-P mice with a congenital paternal Snord116 deletion...
January 29, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29374670/care-cr-cardiovascular-and-cardiorespiratory-adaptations-to-routine-exercise-based-cardiac-rehabilitation-a-study-protocol-for-a-community-based-controlled-study-with-criterion-methods
#8
Simon Nichols, Fiona Nation, Toni Goodman, Andrew L Clark, Sean Carroll, Lee Ingle
INTRODUCTION: Cardiac rehabilitation (CR) reduces all-cause and cardiovascular mortality in patients with coronary heart disease (CHD). Much of this improvement has been attributed to the beneficial effects of structured exercise training. However, UK-based studies have not confirmed this. Improvements in survival and cardiovascular health are associated with concurrent improvements in cardiorespiratory fitness (CRF). It is therefore concerning that estimated CRF improvements resulting from UK-based CR are approximately one-third of those reported in international literature...
January 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29365488/marginal-zone-b-cells-control-follicular-helper-t-cell-response-to-high-cholesterol-diet
#9
Meritxell Nus, Andy P Sage, Yuning Lu, Leanne Masters, Brian Yh Lam, Stephen Newland, Sandra Weller, Dimitrios Tsiantoulas, Juliette Raffort, Damienne Marcus, Alison Finigan, Lauren Kitt, Nichola Figg, Reinhold Schirmbeck, Manfred Kneilling, Giles Sh Yeo, Christoph J Binder, Jose L De La Pompa, Ziad Mallat
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29355431/risk-factors-and-direct-medical-cost-of-early-versus-late-unplanned-readmissions-among-diabetes-patients-at-a-tertiary-hospital-in-singapore
#10
May Ee Png, Joanne Yoong, Cynthia Chen, Chuen Seng Tan, E Shyong Tai, Eric Yh Khoo, Hwee Lin Wee
OBJECTIVE: To examine the risk factors and direct medical cost associated with early (≤30 days) versus late (31-180 days) unplanned readmissions among patients with type 2 diabetes in Singapore. METHODS: Risk factors and its associated cost among diabetes patients were investigated using electronic medical records from a local tertiary care hospital from 2010 to 2012. Multivariable logistic regression was used to identify risk factors associated with early and late unplanned readmissions while a generalized linear model was used to estimate the direct medical cost...
January 22, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29355283/reliability-and-validity-of-the-english-chinese-and-malay-language-versions-of-the-world-health-organization-quality-of-life-whoqol-bref-questionnaire-in-singapore
#11
Yin Bun Cheung, Khung Keong Yeo, Kok Joon Chong, Eric Yh Khoo, Hwee Lin Wee
INTRODUCTION: The World Health Organization Quality of Life (WHOQOL-BREF) questionnaire is a 26-item questionnaire that evaluates 4 domains of quality of life (QoL), namely Physical, Psychological, Social Relationships and Environment. This study aimed to evaluate the validity and reliability of the WHOQOL-BREF among Singapore residents aged 21 and above. MATERIALS AND METHODS: We recruited participants from the general population by using multistage cluster sampling and participants from 2 hospitals by using convenience sampling...
December 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29353462/lactobacillus-kosoi-sp-nov-a-fructophilic-species-isolated-from-k%C3%A3-so-a-japanese-sugar-vegetable-fermented-beverage
#12
Tai-Ying Chiou, Wataru Suda, Kenshiro Oshima, Masahira Hattori, Chiaki Matsuzaki, Kenji Yamamoto, Tomoya Takahashi
A novel Gram-positive, fructophilic, catalase negative, and rod-shaped strain, designated strain 10HT was isolated from kôso, a Japanese sugar-vegetable fermented beverage obtained from a food processing factory in Saku City, Nagano Prefecture, Japan. Phylogenetic analysis based on 16S rRNA gene sequences revealed strain 10HT to belong to the genus Lactobacillus, with closely related type strains being Lactobacillus kunkeei YH-15T (95.5% sequence similarity), Lactobacillus ozensis Mizu2-1T (95.4% sequence similarity), and Lactobacillus apinorum Fhon13NT (95...
January 20, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29348569/genomelandscaper-landscape-analysis-of-genome-fingerprints-maps-assessing-chromosome-architecture
#13
Hannan Ai, Yuncan Ai, Fanmei Meng
Assessing correctness of an assembled chromosome architecture is a central challenge. We create a geometric analysis method (called GenomeLandscaper) to conduct landscape analysis of genome-fingerprints maps (GFM), trace large-scale repetitive regions, and assess their impacts on the global architectures of assembled chromosomes. We develop an alignment-free method for phylogenetics analysis. The human Y chromosomes (GRCh.chrY, HuRef.chrY and YH.chrY) are analysed as a proof-of-concept study. We construct a galaxy of genome-fingerprints maps (GGFM) for them, and a landscape compatibility among relatives is observed...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335318/longitudinal-effect-of-stroke-on-cognition-a-systematic-review
#14
REVIEW
Eugene Yh Tang, Obreniokibo Amiesimaka, Stephanie L Harrison, Emma Green, Christopher Price, Louise Robinson, Mario Siervo, Blossom Cm Stephan
BACKGROUND: Stroke is associated with an increased risk of dementia; however, the impact of stroke on cognition has been found to be variable, such that stroke survivors can show decline, remain stable, or revert to baseline cognitive functioning. Knowing the natural history of cognitive impairment after stroke is important for intervention. The aim of this systematic review is to investigate the longitudinal course of cognitive function in stroke survivors. METHODS AND RESULTS: Three electronic databases (Medline, Embase, PsycINFO) were searched using OvidSP from inception to July 15, 2016...
January 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29329277/synthesis-structural-characterization-antimicrobial-activity-and-in-vitro-biocompatibility-of-new-unsaturated-carboxylate-complexes-with-2-2-bipyridine
#15
Gina Vasile Scăețeanu, Mariana Carmen Chifiriuc, Coralia Bleotu, Crina Kamerzan, Luminiţa Măruţescu, Constantin G Daniliuc, Cătălin Maxim, Larisa Calu, Rodica Olar, Mihaela Badea
The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion and 2,2'-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature of [Mn₃(2,2'-bipy)₂(C₃H₃O₂)₆] (1), meanwhile complexes with general formula [M(2,2'-bipy)(C₃H₃O₂)₂(H₂O)x]∙yH₂O ((2) M: Ni, x = 1, y = 0; (3) M: Cu, x = 1, y = 0; (4) M: Zn, x = 0, y = 1; 2,2'-bipy: 2,2'-bipyridine; C₃H₃O₂: acrylate anion) were shown to be mononuclear...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29279460/silent-cerebral-infarction-in-east-asian-vs-non-asian-atrial-fibrillation-patients%C3%A3-meta-analysis
#16
Keitaro Senoo, Yusuke Kondo, Yoshio Kobayashi, Gregory Yh Lip
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia in the ageing population in East Asia. Silent cerebral infarction (SCI) is defined as cerebral infarction in the absence of corresponding clinical symptoms, and is a highly prevalent and morbid condition in AF. SCI is increasingly being recognized as a risk factor for future stroke, which can lead to cognitive decline or dementia. The latter is an increasingly common health problem in East Asia.Methods and Results:We conducted a meta-analysis to compare the association of AF and SCI between East Asian and non-Asian patients...
December 27, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29231861/sulfonic-acid-functionalization-of-different-zeolites-and-their-use-as-catalysts-in-the-microwave-assisted-etherification-of-glycerol-with-tert-butyl-alcohol
#17
Rafael Estevez, Ivan Iglesias, Diego Luna, Felipa M Bautista
The etherification of glycerol with tert-butyl alcohol in the liquid phase, over different sulfonic acid functionalized zeolites, has been studied. The reaction was carried out using microwaves as a way of heating, measured at autogenous pressure and without any solvent. Dealuminated HY and HZSM-5 zeolites by acid treatment were functionalized with two different organosilica precursors: 3-mercaptopropyltrimethoxysilane (M), which incorporates thiol groups, and 2-(4-chlorosulfonylphenyl)ethyltrimethoxysilane (C), which incorporates the sulfonic acid groups directly...
December 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29224380/ethics-and-practice-of-trials-within-cohorts-an-emerging-pragmatic-trial-design
#18
Scott Yh Kim, James Flory, Clare Relton
BACKGROUND: With increasing emphasis on pragmatic trials, new randomized clinical trial designs are being proposed to enhance the "real world" nature of the data generated. We describe one such design, appropriate for unmasked pragmatic clinical trials in which the control arm receives usual care, called "Trials within Cohorts" that is increasingly used in various countries because of its efficiency in recruitment, advantages in reducing subject burden, and ability to better mimic real-world consent processes...
December 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29224379/just-in-time-consent-the-ethical-case-for-an-alternative-to-traditional-informed-consent-in-randomized-trials-comparing-an-experimental-intervention-with-usual-care
#19
Andrew J Vickers, Danny A Young-Afat, Behfar Ehdaie, Scott Yh Kim
Informed consent for randomized trials often causes significant and persistent anxiety, distress and confusion to patients. Where an experimental treatment is compared to a standard care control, much of this burden is potentially avoidable in the control group. We propose a "just-in-time" consent in which consent discussions take place in two stages: an initial consent to research from all participants and a later specific consent to randomized treatment only from those assigned to the experimental intervention...
December 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29214850/rejoinder
#20
Andrew Vickers, Danny Young-Afat, Behfar Ehdaie, Scott Yh Kim
No abstract text is available yet for this article.
December 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
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