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https://www.readbyqxmd.com/read/27920402/posterior-facet-talocalcaneal-non-osseous-coalition-an-uncommon-but-easily-missed-cause-of-hindfoot-pain
#1
A Yh Tsang, Y Y Cheuk, A Ws Au-Yeung
No abstract text is available yet for this article.
December 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/27920261/effects-of-repetitive-transcranial-magnetic-stimulation-combined-with-sensory-cueing-on-unilateral-neglect-in-subacute-patients-with-right-hemispheric-stroke-a-randomized-controlled-study
#2
Nicole Yh Yang, Kenneth Nk Fong, Cecilia Wp Li-Tsang, D Zhou
OBJECTIVE: To compare the effects of rTMS combined with sensory cueing, rTMS alone, and conventional rehabilitation on unilateral neglect, hemiplegic arm functions and performance of activities of daily living. DESIGN: A single-blinded randomized controlled trial. SETTING: A convalescent hospital. SUBJECTS: Sixty inpatients with left unilateral neglect after stroke. INTERVENTIONS: Patients were randomly assigned to three groups: rTMS combined with sensory cueing, rTMS, and conventional rehabilitation alone...
December 5, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27913171/effects-of-hydraulic-retention-time-hrt-on-denitrification-using-waste-activated-sludge-thermal-hydrolysis-liquid-and-acidogenic-liquid-as-carbon-sources
#3
Yiding Guo, Liang Guo, Mei Sun, Yangguo Zhao, Mengchun Gao, Zonglian She
Waste activated sludge (WAS) internal carbon source can efficiently and economically enhance denitrification, and hydraulic retention time (HRT) is one of the most important operational parameters for denitrification. The effects of HRT on denitrification were investigated with WAS thermal hydrolysis liquid and acidogenic liquid as carbon sources in this study. The optimal HRT was 12h for thermal hydrolysis liquid and 8h for acidogenic liquid, with NO3(-)-N removal efficiency of 91.0% and 97.6%, respectively...
November 15, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27912736/citrus-junos-tanaka-peel-ameliorates-hepatic-lipid-accumulation-in-hepg2-cells-and-in-mice-fed-a-high-cholesterol-diet
#4
Eun Ju Shin, Jae Ho Park, Mi Jeong Sung, Min-Yu Chung, Jin-Taek Hwang
BACKGROUND: Citrus junos Tanaka (yuja), a yellow-coloured citrus fruit has traditionally been consumed in Korea, Japan, and China and has been found effective in preventing certain diseases. However, the inhibitory effect of yuja on hepatic lipid accumulation has not been clearly elucidated thus far. METHODS: The inhibitory effect of yuja on hepatic lipid accumulation was investigated in both cell culture and mouse models. We investigated the inhibitory effect of ethanol extract of yuja peel (YE) using HepG2 cells...
December 3, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27909151/cerebrovascular-disease-associated-risk-factors-and-antithrombotic-therapy-in-a-population-screening-cohort-insights-from-the-belgian-heart-rhythm-week-programme
#5
Marco Proietti, Georges H Mairesse, Peter Goethals, Christophe Scavee, Johan Vijgen, Ivan Blankoff, Yves Vandekerckhove, Gregory Yh Lip
BACKGROUND: Cerebrovascular disease confers a major healthcare burden worldwide and is a major cause of death and disability. Several well-established risk factors, such as atrial fibrillation (AF), are associated with cerebrovascular disease and antithrombotic therapy reduces risk. DESIGN: This study was a subgroup analysis from the Belgian Heart Rhythm Week, a nationwide AF awareness programme. METHODS: We studied subjects screened between 2012 and 2014 with available data on clinical risk factors and antithrombotic treatment...
December 1, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27855103/hyaluronic-acid-binding-sperm-selection-for-assisted-reproduction-treatment-habselect-study-protocol-for-a-multicentre-randomised-controlled-trial
#6
K D Witt, L Beresford, S Bhattacharya, K Brian, A Coomarasamy, R Hooper, J Kirkman-Brown, Y Khalaf, S E Lewis, A Pacey, S Pavitt, R West, D Miller
INTRODUCTION: The selection of a sperm with good genomic integrity is an important consideration for improving intracytoplasmic sperm injection (ICSI) outcome. Current convention selects sperm by vigour and morphology, but preliminary evidence suggests selection based on hyaluronic acid binding may be beneficial. The aim of the Hyaluronic Acid Binding Sperm Selection (HABSelect) trial is to determine the efficacy of hyaluronic acid (HA)-selection of sperm versus conventionally selected sperm prior to ICSI on live birth rate (LBR)...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27815537/pre-participation-cardiovascular-evaluation-for-athletic-participants-to-prevent-sudden-death-position-paper-from-the-ehra-and-the-eacpr-branches-of-the-esc-endorsed-by-aphrs-hrs-and-solaece
#7
Lluís Mont, Antonio Pelliccia, Sanjay Sharma, Alessandro Biffi, Mats Borjesson, Josep Brugada Terradellas, Francois Carré, Eduard Guasch, Hein Heidbuchel, André La Gerche, Rachel Lampert, William McKenna, Michail Papadakis, Silvia G Priori, Mauricio Scanavacca, Paul Thompson, Christian Sticherling, Sami Viskin, Mathew Wilson, Domenico Corrado, Gregory Yh Lip, Bulent Gorenek, Carina Blomström Lundqvist, Bela Merkely, Gerhard Hindricks, Antonio Hernández-Madrid, Deirdre Lane, Guiseppe Boriani, Calambur Narasimhan, Manlio F Marquez, David Haines, Judith Mackall, Pedro Manuel Marques-Vidal, Ugo Corra, Martin Halle, Monica Tiberi, Josef Niebauer, Massimo Piepoli
No abstract text is available yet for this article.
November 4, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27810295/association-of-pcsk9-with-platelet-reactivity-in-patients-with-acute-coronary-syndrome-treated-with-prasugrel-or-ticagrelor-the-pcsk9-react-study
#8
Eliano P Navarese, Michalina Kolodziejczak, Max-Paul Winter, Arman Alimohammad, Irene M Lang, Antonino Buffon, Gregory Yh Lip, Jolanta M Siller-Matula
BACKGROUND: Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) enzyme might be associated with increased activation of platelets. We aimed to assess the relationship between PCSK9 levels, platelet reactivity and ischemic outcomes. METHODS: Consecutive ACS patients receiving prasugrel or ticagrelor and undergoing percutaneous coronary intervention (PCI) were enrolled in a prospective, observational study. Adenosine diphosphate (ADP)-induced platelet aggregation was determined by Multiplate Analyzer in the maintenance phase of treatment with prasugrel or ticagrelor...
October 29, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27790966/epidemiology-and-microbiological-characterization-of-clinical-isolates-of-staphylococcus-aureus-in-a-single-healthcare-region-of-the-uk-2015
#9
C Horner, L Utsi, L Coole, M Denton
We investigated the epidemiology and characterization of isolates of Staphylococcus aureus within the Yorkshire and Humber (YH) region in the UK. In July 2015, each laboratory within YH (n = 14) was assigned two consecutive days during which all clinical isolates of S. aureus were collected. Isolates were tested for antibiotic susceptibilities and the presence of genes encoding methicillin resistance (mecA and mecC), Panton-Valentine leukocidin (PVL) (lukS-PV), and efflux-mediated chlorhexidine resistance (qacA); isolates were also characterized by spa-types...
October 28, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27786274/available-sustainable-alternatives-replace-endangered-animal-horn-based-on-their-proteomic-analysis-and-bio-effect-evaluation
#10
Rui Liu, Fei Wang, Qiong Huang, Jin-Ao Duan, Pei Liu, Erxin Shang, Dong Zhu, Hongmei Wen, Dawei Qian
The use of endangered animal products in traditional Chinese medicine (TCM) and other ethno-medicines is culturally widespread across many regions of Asia. In the present study, traditional efficacies of seven types of animal horn including antipyretic, sedative and procoagulant activities were evaluated. Shotgun proteomic analysis was performed on material from horns following separation into soluble and insoluble fractions. Over 200 proteins were identified in each sample using nano LC-MS/MS, and these were classified according to their molecular function and cellular component using principal component analysis (PCA)...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27780843/binding-of-anti-dsdna-antibodies-to-proximal-tubular-epithelial-cells-contribute-s-to-renal-tubulo-interstitial-inflammation
#11
Susan Yung, Claudia Yc Ng, Kin Yi Au, Kwok Fan Cheung, Qing Zhang, Chenzhu Zhang, Desmond Yh Yap, Mel Km Chau, Tak Mao Chan
Immune deposits are often observed along the tubular basement membrane in patients with lupus nephritis, but the role of anti-dsDNA antibody deposition on tubulo-interstitial inflammation remains to be investigated. We examined the effect of human polyclonal anti-dsDNA antibodies on inflammatory processes in cultured proximal renal tubular epithelial cells (HK-2 cells) and their association with serum levels of IL-6, IL-8 and MCP-1 in patients. Binding of anti-dsDNA antibodies to HK-2 cells was investigated by cellular ELISA, flow cytometry and immunohistochemistry...
October 25, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27779095/associations-between-diabetic-retinopathy-and-systemic-risk-factors
#12
REVIEW
N Wat, R Lm Wong, I Yh Wong
INTRODUCTION: Diabetes mellitus is a systemic disease with complications that include sight-threatening diabetic retinopathy. It is essential to understand the risk factors of diabetic retinopathy before effective prevention can be implemented. The aim of this review was to examine the association between diabetic retinopathy and systemic risk factors. METHODS: A PubMed literature search was performed up to May 2016 to identify articles reporting associations between diabetic retinopathy and systemic risk factors; only publications written in English were included...
December 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/27748805/an-%C3%AE-quaternary-chiral-latam-derivative-yh-304-as-a-novel-broad-spectrum-anticancer-agent
#13
Su Jung Hwang, Hyeung-Geun Park, Yohan Park, Hyo-Jong Lee
Previously, we reported that α-quaternary chiral lactam derivatives have broad spectrum anticancer activity. However, the underlying molecular mechanisms and its relevance are largely unknown. In the present study, we report progress on α-quaternary chiral lactam analogues that address this, focusing on the novel analogue YH-304 as a candidate to broadly target human cancer cells. The effect of YH-304 on cell transformation was assessed by clonogenic assay in non-small cell lung cancer cells (NSCLCs) A549 and 226B...
October 11, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27748785/diabetes-health-profile-18-is-reliable-valid-and-sensitive-in-singapore
#14
Maudrene Ls Tan, Eric Yh Khoo, Konstadina Griva, Yung Seng Lee, Mohamed Amir, Yasmin Lm Zuniga, Jeannette Lee, E Shyong Tai, Hwee Lin Wee
INTRODUCTION: The Diabetes Health Profile-18 (DHP-18) measures diabetes-related psychological well-being in patients with type 2 diabetes mellitus (T2DM). It includes 3 subscales: psychological distress (PD), barriers to activity and disinhibited eating. The psychometric properties of the DHP have not been evaluated in Asia. The aim of this study was to determine the psychometric properties of the DHP in multiethnic Singapore. MATERIALS AND METHODS: Patients between the ages of 18 to 65 diagnosed with diabetes (either type 1 or type 2) for at least 1 year were recruited from a diabetes outpatient clinic in a tertiary hospital...
September 2016: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/27712087/development-and-validation-of-an-ia-lc-ms-method-to-quantitate-active-and-total-b-type-natriuretic-peptide-in-human-plasma
#15
Derek L Chappell, Anita Yh Lee, Harold S Bernstein, Michael E Lassman, Omar F Laterza
AIM: Patients with elevated levels of B-type natriuretic peptide (BNP) and/or NT-proBNP as measured by clinical tests have an elevated risk of heart failure (HF). Despite utility in large clinical studies, both assays are plagued by large biological variability and specificity issues. To address these concerns and further investigate BNP in the HF setting, we developed an LC/MS assay to characterize the ratio of active to total BNP. RESULTS: We have developed and validated a novel immunoaffinity LC/MS assay to measure BNP-derived fragments, as well as 'total BNP' in human plasma...
October 7, 2016: Bioanalysis
https://www.readbyqxmd.com/read/27629776/antiplatelet-versus-anticoagulation-treatment-for-patients-with-heart-failure-in-sinus-rhythm
#16
Eduard Shantsila, Gregory Yh Lip
BACKGROUND: Morbidity in patients with chronic heart failure is high, and this predisposes them to thrombotic complications, including stroke and thromboembolism, which in turn contribute to high mortality. Oral anticoagulants (e.g. warfarin) and antiplatelet agents (e.g. aspirin) are the principle oral antithrombotic agents. Many heart failure patients with sinus rhythm take aspirin because coronary artery disease is the leading cause of heart failure. Oral anticoagulants have become a standard in the management of heart failure with atrial fibrillation...
September 15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27627906/genetic-models-for-breed-quality-and-navel-development-scores-and-its-associations-with-growth-traits-in-beef-cattle
#17
A A Boligon, L De Vargas, D D Silveira, V M Roso, G S Campos, R Z Vaz, F R P Souza
Estimation and prediction ability of linear and threshold models for yearling breed quality score (BQ) and navel development score at weaning (WN) and yearling (YN), considering variances, heritabilities, and rank correlations based on the breeding values predicted for bulls, were compared. Furthermore, it was determined whether BQ, WN, and YN are genetically associated with growth traits (BWG: birth to weaning weight gain, WH: weaning height, WYG: weaning to yearling weight gain, YH: yearling height) to field data of Nelore cattle...
December 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27552990/endovenous-laser-ablation-versus-mechanochemical-ablation-with-clarivein-%C3%A2-in-the-management-of-superficial-venous-insufficiency-lama-trial-study-protocol-for-a-randomised-controlled-trial
#18
Clement C M Leung, Daniel Carradice, Tom Wallace, Ian C Chetter
BACKGROUND: Endovenous thermal techniques, such as endovenous laser ablation (EVLA), are the recommended treatment for truncal varicose veins. However, a disadvantage of thermal techniques is that it requires the administration of tumescent anaesthesia, which can be uncomfortable. Non-thermal, non-tumescent techniques, such as mechanochemical ablation (MOCA) have potential benefits. MOCA combines physical damage to endothelium using a rotating wire, with the infusion of a liquid sclerosant...
August 24, 2016: Trials
https://www.readbyqxmd.com/read/27542408/effects-of-aging-and-coronary-artery-disease-on-sympathetic-neural-recruitment-strategies-during-end-inspiratory-and-end-expiratory-apnea
#19
Mark B Badrov, Sophie Lalande, T Dylan Olver, Neville Suskin, J Kevin Shoemaker
In response to acute physiological stress, the sympathetic nervous system modifies neural outflow through increased firing frequency of lower-threshold axons, recruitment of latent subpopulations of higher-threshold axons, and/or acute modifications of synaptic delays. Aging and coronary artery disease (CAD) often modify efferent muscle sympathetic nerve activity (MSNA). Therefore, we investigated whether CAD (n = 14; 61 ± 10 yr) and/or healthy aging without CAD (OH; n = 14; 59 ± 9 yr) modified these recruitment strategies that normally are observed in young healthy (YH; n = 14; 25 ± 3 yr) individuals...
October 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27519059/genome-sequences-of-three-apple-chlorotic-leaf-spot-virus-isolates-from-hawthorns-in-china
#20
Wei Guo, Wenyan Zheng, Mei Wang, Xiaohong Li, Yue Ma, Hongyan Dai
The genome sequences of Apple chlorotic leaf spot virus (ACLSV) isolates from three accessions of hawthorns (Crataegus pinnatifida) grown at Shenyang Agricultural University were determined using Illumina RNA-seq. To confirm the assembly data from the de novo sequencing, two ACLSV genomic sequences (SY01 and SY02) were sequenced using the Sanger method. The SY01 and SY02 sequences obtained with the Sanger method showed 99.5% and 99.7% nucleotide identity with the transcriptome data, respectively. The genome sequences of the hawthorn isolates SY01, SY02 and SY03 (GenBank accession nos...
2016: PloS One
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