keyword
MENU ▼
Read by QxMD icon Read
search

thiomersal

keyword
https://www.readbyqxmd.com/read/27352907/prevalence-of-delayed-type-and-immediate-type-hypersensitivity-in-healthcare-workers-with-hand-eczema
#1
Kristina S Ibler, Gregor B E Jemec, Lene H Garvey, Tove Agner
BACKGROUND: Occupational contact dermatitis is common in healthcare workers. Although irritant contact dermatitis resulting from wet work is the most frequently reported cause, healthcare workers also constitute high-risk group for the development of allergic contact dermatitis and contact urticaria. OBJECTIVES: To evaluate the prevalence of delayed-type and immediate-type hypersensitivity in 120 healthcare workers with hand eczema. METHODS: One hundred and twenty healthcare workers from three major hospitals in Denmark with self-reported hand eczema within the last year participated in the study...
October 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27004926/metal-allergy-in-eyelid-dermatitis-and-the-evaluation-of-metal-contents-in-eye-shadows
#2
J E Oh, H J Lee, Y W Choi, H Y Choi, J Y Byun
BACKGROUND: Allergic contact dermatitis is a common diagnosis in eyelid dermatitis. Sensitization to metals is prevalent in eyelid dermatitis and colour cosmetic products are frequently suspected as the source of metal exposure. OBJECTIVE: To investigate the contact allergens for eyelid dermatitis and to assess metal contents in eye shadow products. METHODS: Data were collected in the department of dermatology of Ewha Womans University hospital from December 1998 to February 2014...
September 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/26302930/toxicity-of-organic-and-inorganic-mercury-species-in-differentiated-human-neurons-and-human-astrocytes
#3
Hanna Lohren, Lara Blagojevic, Romy Fitkau, Franziska Ebert, Stefan Schildknecht, Marcel Leist, Tanja Schwerdtle
Organic mercury (Hg) species exert their toxicity primarily in the central nervous system. The food relevant Hg species methylmercury (MeHg) has been frequently studied regarding its neurotoxic effects in vitro and in vivo. Neurotoxicity of thiomersal, which is used as a preservative in medical preparations, is to date less characterised. Due to dealkylation of organic Hg or oxidation of elemental Hg, inorganic Hg is present in the brain albeit these species are not able to readily cross the blood brain barrier...
October 2015: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/26267314/the-blood-cerebrospinal-fluid-barrier-first-evidence-for-an-active-transport-of-organic-mercury-compounds-out-of-the-brain
#4
Hanna Lohren, Julia Bornhorst, Hans-Joachim Galla, Tanja Schwerdtle
Exposure to organic mercury compounds promotes primarily neurological effects. Although methylmercury is recognized as a potent neurotoxicant, its transfer into the central nervous system (CNS) is not fully evaluated. While methylmercury and thiomersal pass the blood-brain barrier, limited data are available regarding the second brain regulating interface, the blood-cerebrospinal fluid (CSF) barrier. This novel study was designed to investigate the effects of organic as well as inorganic mercury compounds on, and their transfer across, a porcine in vitro model of the blood-CSF barrier for the first time...
October 2015: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/26022567/communicating-the-role-and-value-of-vaccine-adjuvants
#5
REVIEW
Bruce G Gellin, David M Salisbury
Despite the inclusion of adjuvants in many routinely used vaccines to improve the immune response, their presence and role are neither clear in product details such as the packaging or in the Summaries of Product Characteristics, nor understood by health professionals or the public. For many vaccines the adjuvant may simply be described as 'Adsorbed' without clarification that the adsorbing onto a material such as aluminium hydroxide adjuvants the antigens. As many future vaccines are likely to be adjuvanted, the presence of adjuvants, either those used in existing vaccines or novel formulations, may raise public and professional concerns unless communication materials are prepared in advance to allay anxieties such as those that have arisen over some present vaccine ingredients such as thiomersal...
June 8, 2015: Vaccine
https://www.readbyqxmd.com/read/25981166/toxicological-effects-of-thiomersal-and-ethylmercury-inhibition-of-the-thioredoxin-system-and-nadp-dependent-dehydrogenases-of-the-pentose-phosphate-pathway
#6
Juan Rodrigues, Vasco Branco, Jun Lu, Arne Holmgren, Cristina Carvalho
Mercury (Hg) is a strong toxicant affecting mainly the central nervous, renal, cardiovascular and immune systems. Thiomersal (TM) is still in use in medical practice as a topical antiseptic and as a preservative in multiple dose vaccines, routinely given to young children in some developing countries, while other forms of mercury such as methylmercury represent an environmental and food hazard. The aim of the present study was to determine the effects of thiomersal (TM) and its breakdown product ethylmercury (EtHg) on the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway...
August 1, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/25862449/thiomersal-containing-vaccines-a-review-of-the-current-state-of-knowledge
#7
REVIEW
Aleksandra Gołoś, Anna Lutyńska
Thiomersal is an organomercury compound known for its antiseptic and antifungal properties and used as an antibacterial agent in pharmaceutical products, including vaccines and other injectable biological products. In recent years, concerns about the possible link between immunization with thiomersal-containing vaccines and autism development have grown. Many case-control and cohort studies have been conducted on a number of populations, and none of them have confirmed the hypothetical relation between thiomersal and increased risk of autism spectrum disorders (ASDs) development...
2015: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/25754741/safety-of-vaccination-against-influenza-a-h1n1-during-pregnancy-in-the-netherlands-results-on-pregnancy-outcomes-and-infant-s-health-cross-sectional-linkage-study
#8
N van der Maas, J Dijs-Elsinga, J Kemmeren, A van Lier, M Knol, H de Melker
OBJECTIVE: This study aims to assess the safety of Influenza A(H1N1), vaccination administered during the second and third trimester and containing MF59 and thiomersal (Focetria(®) ), measured by pregnancy outcomes and infant's health. DESIGN: Cross-sectional linkage study. SETTING AND SAMPLE: A sample of pregnant women, eligible for prenatal screening, were invited to participate. METHODS: Questionnaire data were linked with the Netherlands Perinatal Registry (n = 1920)...
April 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/25708367/thimerosal-clinical-epidemiologic-and-biochemical-studies
#9
REVIEW
David A Geier, Paul G King, Brian S Hooker, José G Dórea, Janet K Kern, Lisa K Sykes, Mark R Geier
INTRODUCTION: Thimerosal (or Thiomersal) is a trade name for an organomercurial compound (sodium ethyl-mercury (Hg) thiosalicylate) that is 49.55% Hg by weight, which rapidly decomposes in aqueous saline solutions into ethyl-Hg hydroxide and ethyl-Hg chloride. Developed in 1927, it has been and is still being used as a preservative in some cosmetics, topical pharmaceuticals, and biological drug products, including vaccines. Concerns have been voiced about its use because it is toxic to human cells...
April 15, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/25295057/patch-testing-in-suspected-allergic-contact-dermatitis-to-cosmetics
#10
Pramod Kumar, Rekha Paulose
Background. Increasing use of cosmetics has contributed to a rise in the incidence of allergic contact dermatitis (ACD) to cosmetics. It is estimated that 1-5.4% of the population is sensitized to a cosmetic ingredient. Patch testing helps to confirm the presence of an allergy and to identify the actual allergens which are chemical mixtures of various ingredients. Objectives. The aims of this study are to perform patch testing in suspected ACD to cosmetics and to identify the most common allergen and cosmetic product causing dermatitis...
2014: Dermatology Research and Practice
https://www.readbyqxmd.com/read/25198357/thimerosal-in-vaccines-white-black-or-quite-the-opposite
#11
Gabriel Rada
This article analyzes the recent controversy regarding the introduction of a bill to Chilean Congress that aims to ban thiomersal and/or any trace of organomercurial compounds from vaccines in the country. Rather than providing a formal overview of all available evidence, this analysis focuses on the reasons behind the controversy, the scientific evidence invoked by both sides in the debate, and the anomalies in the healthcare decision-making process.
2014: Medwave
https://www.readbyqxmd.com/read/25197986/a-bioethical-j%C3%A2-accuse-analysis-of-the-discussion-around-thiomersal-in-chile
#12
Miguel Kottow
Chilean legislators have voted to ban vaccines preserved with thiomersal, an initiative that the Executive has vetoed. Most scientific evidence has dismissed the alleged toxicity of this substance, in accordance with the formal and publicly expressed opinion of local experts, and yet, medical authorities have issued contradictory statements. Some have argued that the principle of precaution suggests eliminating thiomersal preserved vaccines; others have declared that current vaccines should be maintained to protect the population...
2014: Medwave
https://www.readbyqxmd.com/read/25132846/cosmetic-contact-sensitivity-in-patients-with-melasma-results-of-a-pilot-study
#13
Neel Prabha, Vikram K Mahajan, Karaninder S Mehta, Pushpinder S Chauhan, Mrinal Gupta
Background. Some of the patients with melasma perhaps have pigmented cosmetic dermatitis. However, cosmetic contact sensitivity in melasma remains poorly studied particularly in the Indian context. Objectives. To study cosmetic contact sensitivity in patients with melasma. Materials and Methods. 67 (F : M = 55 : 12) consecutive patients with melasma between 19 and 49 years of age were patch tested sequentially during January-December, 2012, with Indian Cosmetic and Fragrance Series, Indian Sunscreen Series, p-phenylenediamine, and patient's own cosmetic products...
2014: Dermatology Research and Practice
https://www.readbyqxmd.com/read/25036048/the-safety-and-immunogenicity-of-two-hepatitis-b-vaccine-formulations-thiomersal-free-and-thiomersal-containing-in-healthy-vietnamese-infants-a-phase-iii-prospective-single-blinded-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Nguyen Trong Hieu, Michal Sarnecki, Jeroen Tolboom
BACKGROUND: To evaluate the safety and immunogenicity of the thiomersal-free (TF) and thiomersal-containing (TC) formulations of Hepavax-Gene in healthy Vietnamese neonates. METHODS: A single-blind, randomized, controlled study in Ho Chi Minh City, Vietnam. Healthy infants, born after a normal gestational period (37-42 weeks) to hepatitis B surface antigen-negative mothers, participated in the study. Subjects were randomly allocated in a 1:1 ratio to receive either Hepavax-Gene TC or Hepavax-Gene TF using a standard 0-1-6-month administration schedule...
January 2015: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/24549367/mechanisms-of-hg-species-induced-toxicity-in-cultured-human-astrocytes-genotoxicity-and-dna-damage-response
#15
Imke Pieper, Christoph A Wehe, Julia Bornhorst, Franziska Ebert, Larissa Leffers, Michael Holtkamp, Pia Höseler, Till Weber, Aswin Mangerich, Alexander Bürkle, Uwe Karst, Tanja Schwerdtle
The toxicologically most relevant mercury (Hg) species for human exposure is methylmercury (MeHg). Thiomersal is a common preservative used in some vaccine formulations. The aim of this study is to get further mechanistic insight into the yet not fully understood neurotoxic modes of action of organic Hg species. Mercury species investigated include MeHgCl and thiomersal. Additionally HgCl2 was studied, since in the brain mercuric Hg can be formed by dealkylation of the organic species. As a cellular system astrocytes were used...
March 2014: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/24500362/chile-votes-to-ban-thiomersal-in-vaccines-despite-opposition-from-doctors-and-scientists
#16
Sophie Arie
No abstract text is available yet for this article.
2014: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/24421864/wells-syndrome-eosinophilic-cellulitis-proposed-diagnostic-criteria-and-a-literature-review-of-the-drug-induced-variant
#17
Kara Heelan, John F Ryan, Neil H Shear, Conleth A Egan
BACKGROUND: Wells syndrome is an uncommon inflammatory dermatosis first described in 1971 by Wells. The clinical eruption is characterized by varying morphology and severity and usually follows a relapsing remitting course. The majority of the reported cases are of unknown etiology, drug induced Wells syndrome has rarely been reported. A literature search using MEDLINE was performed. We recorded the features of our case and of the additional cases of drug induced Wells syndrome in the literature...
2013: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/24362099/total-mercury-content-in-canine-hair-before-and-after-administration-of-vaccines-containing-thiomersal
#18
Lenka Sedlackova, Tomas Kral, Marie Sevcikova, Kamila Kruzikova, Zdenka Svobodova
OBJECTIVES: Thiomersal is ethylmercury containing compound. It has been used as a preservative in vaccines since the 1930s because it is very effective in preventing bacterial contamination. Ethylmercury penetrates into growing hair in a similar manner as methylmercury. DESIGN: A total of 48 hair samples were collected from vaccinated dogs. Each sample was accompanied with a questionnaire including data on age, gender, vaccinations. Total mercury content in hair, granules and vaccines was determined by the direct method of cold vapours using an AMA 254 (advance mercury analyser; Altec Ltd...
2013: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/24267064/determination-of-thiomersal-by-flow-injection-coupled-with-microwave-assisted-photochemical-online-oxidative-decomposition-of-organic-mercury-and-cold-vapor-atomic-fluorescence-spectroscopy
#19
Beatrice Campanella, Massimo Onor, Marco Carlo Mascherpa, Alessandro D'Ulivo, Carlo Ferrari, Emilia Bramanti
We developed a flow injection (FI) method for the determination of thiomersal (sodium ethylmercurithiosalicylate, C9H9HgNaO2S) based on the UV/microwave (MW) photochemical, online oxidation of organic mercury, followed by cold vapor generation atomic fluorescence spectrometry (CVG-AFS) detection. Thiomersal was quantitatively converted in the MW/UV process to Hg(II), with a yield of 97±3%. This reaction was followed by the reduction of Hg(II) to Hg(0) performed in a knotted reaction coil with NaBH4 solution, and AFS detection in an Ar/H2 miniaturized flame...
December 4, 2013: Analytica Chimica Acta
https://www.readbyqxmd.com/read/23781630/whole-cell-pertussis-vaccine-reducing-toxicity
#20
Thakur Datta, Devender Sharma, Inderjeet Gandhoke, Shashi Khare, Arun Bhardwaj
Since introduction of the pertussis vaccine in 1940's the morbidity and mortality due to the infection has been markedly reduced all over the world. However the adverse effects of the inactivated whole cell pertussis vaccine like pain, swelling at the site of injection, fever, vomiting anorexia, persistent crying & drowsiness have been the cause of great concern, till date. Also the safety concerns over the use of thiomersal as an inactivating agent as well preservative have been raised in the recent past. Studies in many countries have been initiated to reduce or replace thiomersal & using other inactivating agents in the vaccines...
September 2011: Journal of Communicable Diseases
keyword
keyword
79491
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"