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Neuro-endocrine

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https://www.readbyqxmd.com/read/27904107/epidermoid-cyst-in-an-intrapancreatic-accessory-spleen-case-report-and-literature-review-of-the-preoperative-imaging-findings
#1
Shin Kato, Hideki Mori, Moriya Zakimi, Koki Yamada, Kenji Chinen, Masayuki Arashiro, Susumu Shinoura, Kaoru Kikuchi, Takahiro Murakami, Fumihito Kunishima
An epidermoid cyst arising within an intrapancreatic accessory spleen (ECIAS) is rare, and also difficult to correctly diagnose before surgery. It is mostly misdiagnosed as a cystic tumor, such as a mucinous cystic neoplasm or as a solid tumor with cystic degeneration, such as a neuro endocrine tumor. We herein report a case of ECIAS and also perform a literature review of 35 reports of ECIAS. Although the preoperative diagnosis of ECIAS using conventional imaging is relatively difficult to make, careful preoperative examinations of the features on computed tomography and magnetic resonance imaging could lead to a correct preoperative diagnosis of ECIAS which might thereby reduce the number of unnecessary resections...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27893741/downregulation-of-blood-monocyte-hla-dr-in-icu-patients-is-also-present-in-bone-marrow-cells
#2
Valérie Faivre, Anne-Claire Lukaszewicz, Didier Payen
BACKGROUND: The downregulation of blood monocyte HLA-DR expression also occurs in tissue infiltrative cells in a context of acute clinical inflammation, especially sepsis. This context favors the development of secondary infections and results from various mechanisms. Little is known about HLA-DR expression on bone marrow (BM) cells of the monocyte lineage, the source of circulating monocytes. This study analyzed the BM HLA-DR expression in ICU patients compared to BM monocytes from non-ICU patients and to blood monocytes of control healthy donors...
2016: PloS One
https://www.readbyqxmd.com/read/27891086/circuits-regulating-pleasure-and-happiness-mechanisms-of-depression
#3
Anton J M Loonen, Svetlana A Ivanova
According to our model of the regulation of appetitive-searching vs. distress-avoiding behaviors, the motivation to display these essential conducts is regulated by two parallel cortico-striato-thalamo-cortical, re-entry circuits, including the core and the shell parts of the nucleus accumbens, respectively. An entire series of basal ganglia, running from the caudate nucleus on one side, to the centromedial amygdala on the other side, controls the intensity of these reward-seeking and misery-fleeing behaviors by stimulating the activity of the (pre)frontal and limbic cortices...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27842554/men1-redefined-a-clinical-comparison-of-mutation-positive-and-mutation-negative-patients
#4
Joanne M de Laat, Rob B van der Luijt, Carolina R C Pieterman, Maria P Oostveen, Ad R Hermus, Olaf M Dekkers, Wouter W de Herder, Anouk N van der Horst-Schrivers, Madeleine L Drent, Peter H Bisschop, Bas Havekes, Menno R Vriens, Gerlof D Valk
BACKGROUND: Multiple Endocrine Neoplasia type 1 (MEN1) is diagnosed when two out of the three primary MEN1-associated endocrine tumors occur in a patient. Up to 10-30 % of those patients have no mutation in the MEN1 gene. It is unclear if the phenotype and course of the disease of mutation-negative patients is comparable with mutation-positive patients and if these patients have true MEN1. The present study aims to describe and compare the clinical course of MEN1 mutation-negative patients with two out of the three main MEN1 manifestations and mutation-positive patients during long-term follow-up...
November 15, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27823763/structure-of-neuro-endocrine-and-neuro-epithelial-interactions-in-human-foetal-pancreas
#5
Yuliya Krivova, Alexandra Proshchina, Valeriy Barabanov, Olga Leonova, Sergey Saveliev
In the pancreas of many mammals including humans, endocrine islet cells can be integrated with the nervous system components into neuro-insular complexes. The mechanism of the formation of such complexes is not clearly understood. The present study evaluated the interactions between the nervous system components, epithelial cells and endocrine cells in the human pancreas. Foetal pancreas, gestational age 19-23 weeks (13 cases) and 30-34 weeks (7 cases), were studied using double immunohistochemical labeling with neural markers (S100 protein and beta III tubulin), epithelial marker (cytokeratin 19 (CK19)) and antibodies to insulin and glucagon...
October 26, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27812162/calcium-binding-and-disulfide-bonds-regulate-the-stability-of-secretagogin-towards-thermal-and-urea-denaturation
#6
Kalyani Sanagavarapu, Tanja Weiffert, Niamh Ní Mhurchú, David O'Connell, Sara Linse
Secretagogin is a calcium-sensor protein with six EF-hands. It is widely expressed in neurons and neuro-endocrine cells of a broad range of vertebrates including mammals, fishes and amphibia. The protein plays a role in secretion and interacts with several vesicle-associated proteins. In this work, we have studied the contribution of calcium binding and disulfide-bond formation to the stability of the secretagogin structure towards thermal and urea denaturation. SDS-PAGE analysis of secretagogin in reducing and non-reducing conditions identified a tendency of the protein to form dimers in a redox-dependent manner...
2016: PloS One
https://www.readbyqxmd.com/read/27754425/ouabain-contributes-to-kidney-damage-in-a-rat-model-of-renal-ischemia-reperfusion-injury
#7
Luca Villa, Roberta Buono, Mara Ferrandi, Isabella Molinari, Fabio Benigni, Arianna Bettiga, Giorgia Colciago, Masami Ikehata, Elisabetta Messaggio, Maria Pia Rastaldi, Francesco Montorsi, Andrea Salonia, Paolo Manunta
Warm renal ischemia performed during partial nephrectomy has been found to be associated with kidney disease. Since endogenous ouabain (EO) is a neuro-endocrine hormone involved in renal damage, we evaluated the role of EO in renal ischemia-reperfusion injury (IRI). We measured plasma and renal EO variations and markers of glomerular and tubular damage (nephrin, KIM-1, Kidney-Injury-Molecule-1, α1 Na-K ATPase) and the protective effect of the ouabain inhibitor, rostafuroxin. We studied five groups of rats: (1) normal; (2) infused for eight weeks with ouabain (30 µg/kg/day, OHR) or (3) saline; (4) ouabain; or (5) saline-infused rats orally treated with 100 µg/kg/day rostafuroxin for four weeks...
October 14, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27742703/neuroimmune-cross-talk-in-the-gut-neuroendocrine-and-neuroimmune-pathways-contribute-to-the-pathophysiology-of-irritable-bowel-syndrome
#8
Dervla O'Malley
Irritable bowel syndrome (IBS) is a common disorder characterized by recurrent abdominal pain, bloating, and disturbed bowel habit, symptoms that impact the quality of life of sufferers. The pathophysiological changes underlying this multifactorial condition are complex and include increased sensitivity to luminal and mucosal factors, resulting in altered colonic transit and visceral pain. Moreover, dysfunctional communication in the bidirectional signaling axis between the brain and the gut, which involves efferent and afferent branches of the peripheral nervous system, circulating endocrine hormones, and local paracrine and neurocrine factors, including immune and perhaps even microbial signaling molecules, has a role to play in this disorder...
November 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27739007/changes-in-energy-expenditure-with-weight-gain-and-weight-loss-in-humans
#9
REVIEW
Manfred J Müller, Janna Enderle, Anja Bosy-Westphal
Metabolic adaptation to weight changes relates to body weight control, obesity and malnutrition. Adaptive thermogenesis (AT) refers to changes in resting and non-resting energy expenditure (REE and nREE) which are independent from changes in fat-free mass (FFM) and FFM composition. AT differs in response to changes in energy balance. With negative energy balance, AT is directed towards energy sparing. It relates to a reset of biological defence of body weight and mainly refers to REE. After weight loss, AT of nREE adds to weight maintenance...
December 2016: Current Obesity Reports
https://www.readbyqxmd.com/read/27738345/friend-or-foe-the-dichotomous-impact-of-t-cells-on-neuro-de-re-generation-during-aging
#10
Brandon Coder, Weikan Wang, Liefeng Wang, Zhongdao Wu, Qichuan Zhuge, Dong-Ming Su
The interaction between T cells and the central nervous system (CNS) in homeostasis and injury has been recognized being both pathogenic (CD4+ T-helper 1 - Th1, Th17 and γδT) and ameliorative (Th2 and regulatory T cells - Tregs). However, in-depth studies aimed to elucidate the precise in the aged microenvironment and the dichotomous role of Tregs have just begun and many aspects remain unclear. This is due, not only to a mutual dependency and reciprocal causation of alterations and diseases between the nervous and T cell immune systems, but also to an inconsistent aging of the two systems, which dynamically changes with CNS injury/recovery and/or aging process...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27724938/infection-with-plasmodium-berghei-ookinetes-alters-protein-expression-in-the-brain-of-anopheles-albimanus-mosquitoes
#11
Alejandro Alvarado-Delgado, Guillermo Perales Ortiz, Ángel T Tello-López, Sergio Encarnación, Renaud Conde, Ángel G Martínez-Batallar, Ken Moran-Francia, Humberto Lanz-Mendoza
BACKGROUND: The behaviour of Anopheles spp. mosquitoes, vectors for Plasmodium parasites, plays a crucial role in the propagation of malaria to humans. Consequently, it is important to understand how the behaviour of these mosquitoes is influenced by the interaction between the brain and immunological status. The nervous system is intimately linked to the immune and endocrine systems. There is evidence that the malaria parasite alters the function of these systems upon infecting the mosquito...
October 11, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27694784/myogenic-temporomandibular-disorders-clinical-systemic-comorbidities-in-a-female-population-sample
#12
M de-Pedro-Herráez, J Mesa-Jiménez, C Fernández-de-Las-Peñas, J-L de-la-Hoz-Aizpurua
BACKGROUND: Myogenic temporomandibular disorders (MTMD) frequently coexist with other clinical conditions in the same individual. In the last decades, several authors have analyzed these comorbidities looking for the origin of this overlapping. Objetives: The aim of this study was to perform a comparative anaylisis between a group of patients with MTMD and a control group of dental patients without dysfunctional pathology to assess whether there are significant differences in the presence of systemic medical comorbidities between the two groups...
November 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27617738/blood-pressure-regulation-by-cd4-lymphocytes-expressing-choline-acetyltransferase
#13
Peder S Olofsson, Benjamin E Steinberg, Roozbeh Sobbi, Maureen A Cox, Mohamed N Ahmed, Michaela Oswald, Ferenc Szekeres, William M Hanes, Andrea Introini, Shu Fang Liu, Nichol E Holodick, Thomas L Rothstein, Cecilia Lövdahl, Sangeeta S Chavan, Huan Yang, Valentin A Pavlov, Kristina Broliden, Ulf Andersson, Betty Diamond, Edmund J Miller, Anders Arner, Peter K Gregersen, Peter H Backx, Tak W Mak, Kevin J Tracey
Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously showed that CD4(+) T lymphocytes that express choline acetyltransferase (ChAT), which catalyzes the synthesis of the vasorelaxant acetylcholine, relay neural signals. Here we show that these CD4(+)CD44(hi)CD62L(lo) T helper cells by gene expression are a distinct T-cell population defined by ChAT (CD4 TChAT). Mice lacking ChAT expression in CD4(+) cells have elevated arterial blood pressure, compared to littermate controls...
October 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/27601248/first-ex-vivo-validation-of-a-radioguided-surgery-technique-with-%C3%AE-radiation
#14
E Solfaroli Camillocci, M Schiariti, V Bocci, A Carollo, G Chiodi, M Colandrea, F Collamati, M Cremonesi, R Donnarumma, M E Ferrari, P Ferroli, F Ghielmetti, C M Grana, C Mancini Terracciano, M Marafini, S Morganti, M Patanè, G Pedroli, B Pollo, L Recchia, A Russomando, M Toppi, G Traini, R Faccini
PURPOSE: A radio-guided surgery technique with β(-)-emitting radio-tracers was suggested to overcome the effect of the large penetration of γ radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation of the SUV of the tumor, to the assumptions on the bio-distribution and the signal detection...
September 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27554015/the-variable-clinicopathological-categories-and-role-of-human-papillomavirus-in-cervical-adenocarcinoma-a-hospital-based-nation-wide-multi-center-retrospective-study-across-china
#15
Wen Chen, Anco Molijn, Wu Enqi, Xun Zhang, David Jenkins, Xiaohong Yu, Wim Quint, Johannes E Schmidt, Jing Li, Edyta Pirog, Bin Liu, Qing Li, Xiaoyang Liu, Ling Li, Youlin Qiao
We investigated HPV in adenocarcinoma presenting and managed as cervical adenocarcinoma (CADC) at seven major representative regional cancer centres across China. From 1,051 CADC cases diagnosed locally in 2005-2010, 881 had available paraffin embedded tissue. Initial review excluded 154 cases as other diagnoses or inappropriate specimens. In 718 eligible cases consensus panel pathology diagnosis was made using an algorithm incorporating p16 and progesterone receptor immunohistochemistry (IHC). Classification of cervical adenocarcinoma categories was subject to substantial pathological disagreement...
December 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27453669/giant-cystic-pheochromocytoma-a-silent-entity
#16
Amit Gupta, Lovenish Bains, Manish Kumar Agarwal, Renu Gupta
Pheochromocytoma is a catecholamine secreting tumor that originate from chromaffin cells. Usually, it is solid neoplasm of the adrenal medulla, however cystic pheochromocytoma is a rare neuro-endocrine tumour that is frequently asymptomatic and often diagnosed incidentally on imaging or intra-operatively. Only a few cases of cystic pheochromocytomas have been reported in the world literature. We present a case of giant cystic pheochromocytoma in a 65 years old lady who presented with a large retroperitoneal lump, which is probably the world's third largest pheochromocytoma as per the available indexed literature...
July 2016: Urology Annals
https://www.readbyqxmd.com/read/27453459/the-role-of-macrophages-in-anti-inflammatory-activity-of-antidepressant-drugs
#17
Katarzyna Nazimek, Spencer Strobel, Paweł Bryniarski, Michael Kozlowski, Iwona Filipczak-Bryniarska, Krzysztof Bryniarski
Depression is a common disease influencing patients' quality of life, whose etiology involves complex interactions of environmental, genetic and immunological factors. The latter factors include proinflammatory activation of monocytes and macrophages and increased serum levels of proinflammatory cytokines, altogether formulated as the "macrophage theory of depression". Our current review summarizes the impact of the most commonly used antidepressant drugs on the immune response with special emphasis on the role of macrophages in the clinically observed effects...
July 14, 2016: Immunobiology
https://www.readbyqxmd.com/read/27449685/secreting-follicle-stimulating-hormone-pituitary-carcinoma-with-cervical-metastasis
#18
Carly Grandidge, Andy Hall, Neil Kitchen
BACKGROUND: Pituitary carcinoma is defined by either metastases outside the central nervous system or noncontiguous foci within the central nervous system. This case report details the first documented case of a pathologically isolated follicle-stimulating hormone-secreting pituitary carcinoma and its presentation of metastasis. CASE DESCRIPTION: A 63-year-old man developed intrascapular pain radiating up his neck to his occiput. He had undergone a transsphenoidal hypophysectomy 2 years previously for an atypical pituitary macroadenoma...
September 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27376875/the-role-of-autosuggestion-in-geriatric-patients-quality-of-life-a-study-on-psycho-neuro-endocrine-immunology-pathway
#19
Nina Kemala Sari, Siti Setiati, Akmal Taher, Martina Wiwie, Samsuridjal Djauzi, Jacub Pandelaki, Jan Sudir Purba, Mohamad Sadikin
BACKGROUND There has been no study conducted about the effect of autosuggestion on quality of life for geriatric patients. Our aim was to evaluate the efficacy of autosuggestion for geriatric patients' quality of life and its impact on psycho-neuro-endocrine-immune pathway. METHODS Sixty geriatric patients aged ≥60 years in a ward were randomly assigned to either receive autosuggestion or not. Autosuggestion was recorded in a tape to be heard daily for 30 days. Both groups received the standard medical therapy...
July 4, 2016: Social Neuroscience
https://www.readbyqxmd.com/read/27271987/neuro-modulation-of-immuno-endocrine-response-induced-by-kaliotoxin-of-androctonus-scorpion-venom
#20
Amina Ladjel-Mendil, Marie-France Martin-Eauclaire, Fatima Laraba-Djebari
Kaliotoxin (KTX), a specific blocker of potassium channels, exerts various toxic effects due to its action on the central nervous system. Its use in experimental model could help the understanding of the cellular and molecular mechanisms involved in the neuropathological processes related to potassium channel dysfunctions. In this study, the ability of KTX to stimulate neuro-immuno-endocrine axis was investigated. As results, the intracerebroventricular injection of KTX leads to severe structural-functional alterations of both hypothalamus and thyroid...
June 7, 2016: Journal of Biochemical and Molecular Toxicology
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