Nikolaos Svoronos, Alfredo Perales-Puchalt, Michael J Allegrezza, Melanie R Rutkowski, Kyle K Payne, Amelia J Tesone, Jenny M Nguyen, Tyler J Curiel, Mark G Cadungog, Sunil Singhal, Evgeniy B Eruslanov, Paul Zhang, Julia Tchou, Rugang Zhang, Jose R Conejo-Garcia
The role of estrogens in antitumor immunity remains poorly understood. Here, we show that estrogen signaling accelerates the progression of different estrogen-insensitive tumor models by contributing to deregulated myelopoiesis by both driving the mobilization of myeloid-derived suppressor cells (MDSC) and enhancing their intrinsic immunosuppressive activity in vivo Differences in tumor growth are dependent on blunted antitumor immunity and, correspondingly, disappear in immunodeficient hosts and upon MDSC depletion...
January 2017: Cancer Discovery