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Myeloid derived supressor cells

Nikolaos Svoronos, Alfredo Perales-Puchalt, Michael J Allegrezza, Melanie R Rutkowski, Kyle K Payne, Amelia J Tesone, Jenny M Nguyen, Tyler J Curiel, Mark G Cadungog, Sunil Singhal, Evgeniy B Eruslanov, Paul Zhang, Julia Tchou, Rugang Zhang, Jose R Conejo-Garcia
The role of estrogens in anti-tumor immunity remains poorly understood. Here we show that estrogen signaling accelerates the progression of different estrogen insensitive tumor models by contributing to deregulated myelopoiesis by both driving the mobilization of myeloid-derived suppressor cells (MDSCs) and enhancing their intrinsic immunosuppressive activity in vivo. Differences in tumor growth are dependent on blunted anti-tumor immunity and, correspondingly, disappear in immunodeficient hosts and upon MDSC depletion...
September 30, 2016: Cancer Discovery
Barbora Brodská, Petra Otevřelová, Aleš Holoubek
Restoration of cellular apoptotic pathways plays a crucial role in cancer therapy strategies. In a broad spectrum of anticancer drugs, epigenetic effectors are in the center of interest mostly because of potential reversibility of their action. Methylation status of the cells is influenced by methyltransferase inhibitor 2-deoxy-5'-azacytidine (decitabine, DAC), but higher concentrations of this agent cause a DNA-damage. In our study, tumor supressor p53-apoptotic pathway was activated in decitabine-induced cell death...
April 2011: Molecular and Cellular Biochemistry
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