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Influenza Pandemic

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https://www.readbyqxmd.com/read/28346498/characteristics-of-seasonal-influenza-a-and-b-in-latin-america-influenza-surveillance-data-from-ten-countries
#1
Saverio Caini, Wladimir J Alonso, Angel Balmaseda, Alfredo Bruno, Patricia Bustos, Leticia Castillo, Celina de Lozano, Doménica de Mora, Rodrigo A Fasce, Walquiria Aparecida Ferreira de Almeida, Gabriela F Kusznierz, Jenny Lara, Maria Luisa Matute, Brechla Moreno, Claudio Maierovitch Pessanha Henriques, Juan Manuel Rudi, Clotilde El-Guerche Séblain, François Schellevis, John Paget
INTRODUCTION: The increased availability of influenza surveillance data in recent years justifies an actual and more complete overview of influenza epidemiology in Latin America. We compared the influenza surveillance systems and assessed the epidemiology of influenza A and B, including the spatio-temporal patterns of influenza epidemics, in ten countries and sub-national regions in Latin America. METHODS: We aggregated the data by year and country and characteristics of eighty-two years were analysed...
2017: PloS One
https://www.readbyqxmd.com/read/28343775/lower-vaccine-uptake-amongst-older-individuals-living-alone-a-systematic-review-and-meta-analysis-of-social-determinants-of-vaccine-uptake
#2
REVIEW
Anu Jain, A J van Hoek, Delia Boccia, Sara L Thomas
INTRODUCTION: Vaccination is a key intervention to reduce infectious disease mortality and morbidity amongst older individuals. Identifying social factors for vaccine uptake enables targeted interventions to reduce health inequalities. OBJECTIVE: To systematically appraise and quantify social factors associated with vaccine uptake amongst individuals aged ≥60years from Europe. METHODS: We searched Medline and Embase from inception to 24/02/2016...
March 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28342667/a-fast-and-efficient-purification-platform-for-cell-based-influenza-viruses-by-flow-through-chromatography
#3
Yu-Fen Tseng, Tsai-Chuan Weng, Chia-Chun Lai, Po-Ling Chen, Min-Shi Lee, Alan Yung-Chih Hu
Since newly emerging influenza viruses with pandemic potentials occurred in recent years, the demand for producing pandemic influenza vaccines for human use is high. For the development of a quick and efficient vaccine production, we proposed an efficient purification platform from the harvest to the purified bulk for the cell-based influenza vaccine production. This platform based on flow-through chromatography and filtration steps and the process only involves a few purification steps, including depth filtration, inactivation by formaldehyde, microfiltration, ultrafiltration, anion-exchange and ligand-core chromatography and sterile filtration...
March 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28338150/stereoselective-synthesis-of-novel-adamantane-derivatives-with-high-potency-against-rimantadine-resistant-influenza-a-virus-strains
#4
Nikolai Yu Kuznetsov, Rabdan M Tikhov, Ivan A Godovikov, Michael G Medvedev, Konstantin A Lyssenko, Elena I Burtseva, Elena S Kirillova, Yuri N Bubnov
A series of (R)- and (S)-isomers of new adamantane-substituted heterocycles (1,3-oxazinan-2-one, piperidine-2,4-dione, piperidine-2-one and piperidine) with potent activity against rimantadine-resistant strains of influenza A virus were synthesized through the transformation of adamantyl-substituted N-Boc-homoallylamines 8 into piperidine-2,4-diones 11 through the cyclic bromourethanes 9 and key intermediate enol esters 10. Biological assays of the prepared compounds were performed on the rimantadine-resistant S31N mutated strains of influenza A - A/California/7/2009(H1N1)pdm09 and modern pandemic strain A/IIV-Orenburg/29-L/2016(H1N1)pdm09...
March 24, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28337863/zoonotic-influenza-viruses-antigenic-and-genetic-characteristics-and-development-of-candidate-vaccine-viruses-for-pandemic-preparedness
#5
(no author information available yet)
No abstract text is available yet for this article.
March 24, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/28337196/salmonella-typhi-porins-ompc-and-ompf-are-potent-adjuvants-for-t-dependent-and-t-independent-antigens
#6
Marisol Pérez-Toledo, Nuriban Valero-Pacheco, Rodolfo Pastelin-Palacios, Cristina Gil-Cruz, Christian Perez-Shibayama, Mario A Moreno-Eutimio, Ingeborg Becker, Sonia Mayra Pérez-Tapia, Lourdes Arriaga-Pizano, Adam F Cunningham, Armando Isibasi, Laura C Bonifaz, Constantino López-Macías
Several microbial components, such as bacterial DNA and flagellin, have been used as experimental vaccine adjuvants because of their inherent capacity to efficiently activate innate immune responses. Likewise, our previous work has shown that the major Salmonella Typhi (S. Typhi) outer membrane proteins OmpC and OmpF (porins) are highly immunogenic protective antigens that efficiently stimulate innate and adaptive immune responses in the absence of exogenous adjuvants. Moreover, S. Typhi porins induce the expression of costimulatory molecules on antigen-presenting cells through toll-like receptor canonical signaling pathways...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28332900/fc-or-not-fc-that-is-the-question-antibody-fc-receptor-interactions-are-key-to-universal-influenza-vaccine-design
#7
Sinthujan Jegaskanda, Hillary A Vanderven, Adam K Wheatley, Stephen J Kent
A universal vaccine that provides long-lasting protection from both epidemic and pandemic influenza viruses remains the "holy grail" of influenza vaccine research. Though virus neutralization assays are the current benchmark of measuring vaccine effectiveness, it is clear that Fc-receptor functions can drastically improve the effectiveness of antibodies and vaccines in vivo. Antibodies that kill virus-infected cells and/or elicit an antiviral environment, termed antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies, provide a link between the innate and adaptive immune response...
March 23, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28332646/the-role-of-animal-reservoirs-in-social-environmental-landscapes-remarks-on-the-control-of-avian-influenza-and-preparedness-for-pandemics
#8
M P Ortiz-Rodríguez, G C Ramírez-Nieto, L C Villamil-Jiménez
Influenza viruses are well known for their ability to infect and cause disease in a broad range of hosts. Modern advances in reverse genetics have enabled scientists to probe the mutations that allow influenza viruses to perform host switching. Despite this detailed understanding of the molecular modifications that allow host switching and adaptation, there is a gap in knowledge regarding the factors external to the virus and their interactions that act as triggers leading to a pandemic. Studies on the ecology of zoonotic pathogens should be the new paradigm for understanding not only influenza viruses but any other infectious disease that can be a threat to animal and human health...
December 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28331286/neutralizing-activities-against-seasonal-influenza-viruses-in-human-intravenous-immunoglobulin
#9
Hiroyuki Onodera, Takeru Urayama, Kazue Hirota, Kazuhiro Maeda, Ritsuko Kubota-Koketsu, Kazuo Takahashi, Katsuro Hagiwara, Yoshinobu Okuno, Kazuyoshi Ikuta, Mikihiro Yunoki
Influenza viruses A/H1N1, A/H3N2, and B are known seasonal viruses that undergo annual mutation. Intravenous immunoglobulin (IVIG) contains anti-seasonal influenza virus globulins. Although the virus-neutralizing (VN) titer is an indicator of protective antibodies, changes in this titer over extended time periods have yet to be examined. In this study, variations in hemagglutination inhibition (HI) and VN titers against seasonal influenza viruses in IVIG lots over extended time periods were examined. In addition, the importance of monitoring the reactivity of IVIG against seasonal influenza viruses with varying antigenicity was evaluated...
2017: Biologics: Targets & Therapy
https://www.readbyqxmd.com/read/28331085/heterologous-packaging-signals-on-ha-but-not-na-or-ns-limit-influenza-a-virus-reassortment
#10
Maria C White, John Steel, Anice C Lowen
Influenza A virus (IAV) RNA packaging signals serve to direct the incorporation of IAV gene segments into virus particles, and this process is thought to be mediated by segment-segment interactions. These packaging signals are segment- and strain-specific, and as such, they have the potential to impact reassortment outcomes between different IAV strains. Our study aimed to quantify the impact of packaging signal mismatch on IAV reassortment using the human seasonal influenza A/Panama/2007/99 (H3N2) and pandemic influenza A/Netherlands/602/2009 (H1N1) viruses...
March 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28325922/variability-in-h9n2-haemagglutinin-receptor-binding-preference-and-the-ph-of-fusion
#11
Thomas P Peacock, Donald J Benton, Jean-Remy Sadeyen, Pengxiang Chang, Joshua E Sealy, Juliet E Bryant, Stephen R Martin, Holly Shelton, John W McCauley, Wendy S Barclay, Munir Iqbal
H9N2 avian influenza viruses are primarily a disease of poultry; however, they occasionally infect humans and are considered a potential pandemic threat. Little work has been performed to assess the intrinsic biochemical properties related to zoonotic potential of H9N2 viruses. The objective of this study, therefore, was to investigate H9N2 haemagglutinins (HAs) using two well-known correlates for human adaption: receptor-binding avidity and pH of fusion. Receptor binding was characterized using bio-layer interferometry to measure virus binding to human and avian-like receptor analogues and the pH of fusion was assayed by syncytium formation in virus-infected cells at different pHs...
March 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28325769/analysis-of-anti-influenza-virus-neuraminidase-antibodies-in-children-adults-and-the-elderly-by-elisa-and-enzyme-inhibition-evidence-for-original-antigenic-sin
#12
Madhusudan Rajendran, Raffael Nachbagauer, Megan E Ermler, Paul Bunduc, Fatima Amanat, Ruvim Izikson, Manon Cox, Peter Palese, Maryna Eichelberger, Florian Krammer
Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity to a panel of N1, N2, and influenza B virus neuraminidases in different age groups, including children, adults, and the elderly. Using enzyme-linked immunosorbent assays (ELISA), we determined the breadth, magnitude, and isotype distribution of neuraminidase antibody responses to historic, current, and avian strains, as well as to recent isolates to which these individuals have not been exposed...
March 21, 2017: MBio
https://www.readbyqxmd.com/read/28325625/-serological-detection-of-brucella-suis-influenza-virus-and-aujeszky-s-disease-virus-in-backyard-and-small-swine-holders-in-argentina
#13
Marina Dibarbora, Javier A Cappuccio, María N Aznar, Fernando A Bessone, Hernán Piscitelli, Ariel J Pereda, Daniel R Pérez
Farmers raising less than 100 sows represent more than 99% of swine producers in Argentina, although little is known about their sanitary status and productive characteristics in the country. Sanitary and productive information was obtained. Furthermore, samples for serological studies were taken to detect antibodies against Brucella suis (Bs), Aujeszky's disease virus (AV) and influenza virus (IV) in 68 backyard and small producers with less than 100 sows located in the north, central and south regions of Argentina...
March 18, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28325494/modelling-h5n1-in-bangladesh-across-spatial-scales-model-complexity-and-zoonotic-transmission-risk
#14
Edward M Hill, Thomas House, Madhur S Dhingra, Wantanee Kalpravidh, Subhash Morzaria, Muzaffar G Osmani, Mat Yamage, Xiangming Xiao, Marius Gilbert, Michael J Tildesley
Highly pathogenic avian influenza H5N1 remains a persistent public health threat, capable of causing infection in humans with a high mortality rate while simultaneously negatively impacting the livestock industry. A central question is to determine regions that are likely sources of newly emerging influenza strains with pandemic causing potential. A suitable candidate is Bangladesh, being one of the most densely populated countries in the world and having an intensifying farming system. It is therefore vital to establish the key factors, specific to Bangladesh, that enable both continued transmission within poultry and spillover across the human-animal interface...
February 21, 2017: Epidemics
https://www.readbyqxmd.com/read/28322691/discussion-of-average-versus-extreme-case-severity-in-pandemic-risk-communications
#15
Brian J Zikmund-Fisher, Aaron M Scherer, Megan Knaus, Enny Das, Angela Fagerlin
To investigate determinants of the public's perceptions of disease threat, in 2015 we conducted a randomized survey experiment in the Netherlands. Adults who read a mock news article describing average +or extreme outcomes from a hypothetical influenza pandemic were more influenced by average than by extreme case information. Presenting both types of information simultaneously appeared counterproductive.
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28322289/poly-%C3%AE-glutamic-acid-chitosan-nanogel-greatly-enhances-the-efficacy-and-heterosubtypic-cross-reactivity-of-h1n1-pandemic-influenza-vaccine
#16
Jihyun Yang, Sang-Mu Shim, Thi Quyen Nguyen, Eun-Ha Kim, Kwang Kim, Yong Taik Lim, Moon-Hee Sung, Richard Webby, Haryoung Poo
In 2009, the global outbreak of an influenza pandemic emphasized the need for an effective vaccine adjuvant. In this study, we examined the efficacy of poly-γ-glutamic acid/chitosan (PC) nanogel as an adjuvant for the influenza vaccine. PC nanogel significantly enhanced antigen-specific cross-presentation and cytotoxic T lymphocyte (CTL) activity. Compared with alum, the protective efficacy of the pandemic H1N1 influenza (pH1N1) vaccine was substantially increased by PC nanogel, with increased hemagglutination-inhibition titers, CTL activity, and earlier virus clearance after homologous and heterosubtypic [A/Philippines/2/82 (H3N2)] virus challenges...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321029/influenza-a-virus-infection-in-japanese-wild-boars-sus-scrofa-leucomystax
#17
Hiroshi Shimoda, Dung VAN Nguyen, Kenzo Yonemitsu, Shohei Minami, Nao Nagata, Nanami Hara, Ryusei Kuwata, Shin Murakami, Yuuji Kodera, Tsutomu Takeda, Yasuhiro Yoshikawa, Taisuke Horimoto, Ken Maeda
Serum samples were collected from 385 wild boars between 2010 and 2013 to examine the seroprevalence of influenza A virus (IAV) in Japan. Antibodies against IAV were identified using a commercial kit in 13 wild boars (3.4%). To identify the serotypes, positive sera were examined by virus-neutralization test using representative serotypes and strains. Three wild boars in Yamaguchi and four in Tochigi showed the highest antibody titers against the pandemic H1N1 2009 virus and classical swine H1N1 virus strains, respectively...
March 19, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28315708/2016-international-meeting-of-the-global-virus-network
#18
REVIEW
Ramesh Akkina, Heinz Ellerbrok, William Hall, Hideki Hasegawa, Yasushi Kawaguchi, Harold Kleanthous, Edward McSweegan, Natalia Mercer, Victor Romanowski, Hirofumi Sawa, Anders Vahlne
The Global Virus Network (GVN) was established in 2011 in order to strengthen research and responses to current viral causes of human disease and to prepare against new viral pandemic threats. There are now 38 GVN Centers of Excellence and 6 Affiliate laboratories in 24 countries. GVN scientists meet annually to learn about each other's current research, address collaborative priorities and plan future programs. The 2016 meeting was held from October 23-25 in Hokkaido, Japan, in partnership with the Japanese Society for Virology, the National Institute of Infectious Diseases of Japan and the Research Center for Zoonosis Control of Hokkaido University...
March 16, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28302409/effectiveness-of-2009-pandemic-influenza-a-h1n1-vaccines-a-systematic-review-and-meta-analysis
#19
REVIEW
Louise E Lansbury, Sherie Smith, Walter Beyer, Emina Karamehic, Eva Pasic-Juhas, Hana Sikira, Ana Mateus, Hitoshi Oshitani, Hongxin Zhao, Charles R Beck, Jonathan S Nguyen-Van-Tam
BACKGROUND: The clinical effectiveness of monovalent influenza A(H1N1)pdm09 vaccines has not been comprehensively summarised. We undertook a systematic review and meta-analysis to assess vaccine effectiveness (VE) for adjuvanted and unadjuvanted vaccines. METHODS: We searched healthcare databases and grey literature from 11 June 2009 to 12 November 2014. Two researchers independently assessed titles and abstracts to identify studies for full review. Random effects meta-analyses estimated the pooled effect size of vaccination compared to placebo or no vaccination for crude and adjusted odds ratios (OR) to prevent laboratory confirmed influenza illness (LCI) and related hospitalization...
March 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28302408/narcolepsy-and-hypersomnia-in-norwegian-children-and-young-adults-following-the-influenza-a-h1n1-2009-pandemic
#20
Lill Trogstad, Inger Johanne Bakken, Nina Gunnes, Sara Ghaderi, Camilla Stoltenberg, Per Magnus, Siri E Håberg
BACKGROUND: Associations between influenza infection and sleep disorders are poorly studied. We investigated if pandemic influenza infection or vaccination with Pandemrix in 2009/2010 was associated with narcolepsy or hypersomnia in children and young adults. METHODS: We followed the Norwegian population under age 30 from January 2008 through December 2012 by linking national health registry data. Narcolepsy diagnoses were validated using hospital records. Risks of narcolepsy or hypersomnia were estimated as adjusted hazard ratios (HRs) in Cox regression models with influenza infection and vaccination as time-dependent exposures...
March 13, 2017: Vaccine
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