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https://www.readbyqxmd.com/read/28545207/quality-and-reactivity-of-dissolved-organic-matter-in-a-mediterranean-river-across-hydrological-and-spatial-gradients
#1
Elisabet Ejarque, Anna Freixa, Eusebi Vazquez, Alba Guarch, Stefano Amalfitano, Stefano Fazi, Anna M Romaní, Andrea Butturini
Understanding DOM transport and reactivity in rivers is essential to having a complete picture of the global carbon cycle. In this study, we explore the effects of hydrological variability and downstream transport on dissolved organic matter (DOM) dynamics in a Mediterranean river. We sampled the main stem of the river Tordera from the source to the sea, over a range of fifteen hydrological conditions including extreme events (flood and drought). By exploring spatial and temporal gradients of DOM fluorescence properties, river hydrology was found to be a significant predictor of DOM spatial heterogeneity...
May 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28544416/global-analysis-of-strategies-to-tackle-antimicrobial-resistance
#2
Funke Adeniji
BACKGROUND: Antimicrobial resistance (AMR) is a global public health issue driven by inappropriate use of antimicrobials resulting in decreased efficacy on the background of an extremely limited pipeline for new antibiotics. We sought to analyse the effectiveness of key policies and strategies in tackling AMR globally and identify gaps in these. METHOD: The scope, magnitude, history and drivers of AMR were reviewed using supporting evidence. Our methodology included a literature review and semi-structured survey, whilst the analyses process was guided by an adapted health policy analyses framework...
May 22, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28544162/benzimidazole-scaffold-as-anticancer-agent-synthetic-approaches-and-structure-activity-relationship
#3
REVIEW
Neelima Shrivastava, Mohd Javed Naim, Md Jahangir Alam, Farah Nawaz, Shujauddin Ahmed, Ozair Alam
Cancer, also known as malignant neoplasm, is a dreadful disease which involves abnormal cell growth having the potential to invade or spread to other parts of the body. Benzimidazole is an organic compound that is heterocyclic and aromatic in nature. It is a bicyclic compound formed by the fusion of the benzene and imidazole ring systems. It is an important pharmacophore and a privileged structure in medicinal chemistry. According to the World Health Organisation (2015 survey), one in six deaths is due to cancer around the globe, accounting for 8...
May 22, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28544066/type-2-diabetes-and-glucose-intolerance-in-a-population-with-intellectual-disabilities-the-stop-diabetes-cross-sectional-screening-study
#4
A J Dunkley, F Tyrer, L J Gray, S Bhaumik, R Spong, Y Chudasama, S-A Cooper, S Ganghadaran, M Davies, K Khunti
BACKGROUND: Adults with intellectual disabilities (ID) may be at increased risk of developing type 2 diabetes and cardiovascular disease, due to lifestyle factors, medications and other diagnosed conditions. Currently, there is lack of evidence on prevalence and prevention in this population. The aim of this study was to conduct a diabetes screening programme to determine prevalence of previously undiagnosed type 2 diabetes and impaired glucose regulation in people with ID. METHODS: Screening was conducted in a variety of community settings in Leicestershire, UK...
May 21, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28543868/development-and-demolition-a-career-in-mental-health-nursing-and-10-lessons-learned
#5
T Butterworth
Presented as part of the Ellen Skellern lifetime achievement award in 2016 this paper reflects on a career in mental health nursing and academia spanning 53 years. The presentation offers a series of key lessons learned in that time. They include observations on health care organisations, educational experiences, the nursing profession and the illusion of permanence in health care service organisations and the buildings that house them. The paper offers an account of how a profession must constantly develop to be relevant and how the demolition of both buildings and organisations have been a fact of life in the five decades reported...
June 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28543866/testicular-structure-and-seminal-pathway-in-the-yellowtail-tetra-astyanax-altiparanae-characiforms-characidae
#6
D H de Siqueira-Silva, A P Dos Santos-Silva, C Bashiyo-Silva, M S Rodrigues, C A Vicentini, A Ninhaus-Silveira, R Veríssimo-Silveira
This study aimed to describe testicular and its main ducts structure in the yellowtail tetra Astyanax altiparanae, contributing to the knowledge of the region in which semen is produced, storage and released, focusing mainly on the dynamic of germinal epithelium and Sertoli cells during germ cell maturation. Ten sexually mature male A. altiparanae had their testes processed according to the routine protocols to optical microscopy. Moreover, spermatic ducts and tubular compartment of the testes of three specimens were perfused with vinyl resin for gross anatomy and scanning electron microscopy...
May 22, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/28543671/patient-centred-dietetic-care-from-the-perspectives-of-older-malnourished-patients
#7
E Hazzard, L Barone, M Mason, K Lambert, A McMahon
BACKGROUND: Governing organisations for health services currently recommend a patient-centred (PC) approach to practice for all health professions, including dietetics. For the vulnerable older malnourished patient, this approach needs to be prioritised to improve outcomes. The paucity of patient experience data likely limits evidence-based, patient-centred care (PCC) from being implemented effectively. The present study aimed to identify quality indicators of dietetic services from the perspectives of older malnourished patients to inform evidence-based PC dietetic care...
May 22, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28543670/health-and-social-care-planning-in-collaboration-in-older-persons-homes-the-perspectives-of-older-persons-family-members-and-professionals
#8
Malin Sundström, Pia Petersson, Margareta Rämgård, Linda Varland, Kerstin Blomqvist
Providing health and social care to older persons is challenging, since older persons often have multiple diseases and a complex health situation. Hence many professions and organisations are involved. Lack of interprofessional and interorganisational collaboration leads to fragmented care. Care planning meetings before hospital discharge have long been used to overcome this fragmentation, but meetings conducted at the hospital have limitations in identifying long-term needs at home. A new model for health and social care planning in collaboration (HSCPC) in older persons' homes was introduced in two Swedish municipalities...
May 24, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28543624/areas-for-quality-improvements-in-heart-failure-care-quality-of-care-from-the-family-members-perspective
#9
Karin Hellström Ängerud, Kurt Boman, Margareta Brännström
BACKGROUND: The complex needs of people with chronic heart failure (HF) place great demands on their family members, and it is important to ask family members about their perspectives on the quality of HF care. OBJECTIVE: To describe family members' perceptions of quality of HF care in an outpatient setting. METHODS: A cross-sectional study using a short form of the Quality from Patients' Perspective (QPP) questionnaire for data collection...
May 24, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28543602/a-longitudinal-mixed-methods-investigation-of-newly-qualified-nurses-workplace-stressors-and-stress-experiences-during-transition
#10
Yvonne Halpin, Louise M Terry, Joan Curzio
AIM: To investigate transition in newly qualified nurses through an exploration of their stressors and stress experiences during their first 12 months post-qualifying. BACKGROUND: Globally, thousands of new nurses qualify annually. They are crucial for the profession and healthcare service delivery. Work-related stress has multiple serious consequences, yet there is a lack of robust, empirical evidence that directly analyses newly qualified nurses and the stress they feel and experience in the workplace...
May 24, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28542900/the-sensory-trigeminal-complex-and-the-organisation-of-its-primary-afferents-in-the-zebra-finch-taeniopygia-guttata
#11
Macarena Faunes, J Martin Wild, Thomas Finger
Our knowledge of the avian sensory trigeminal system has been largely restricted to the principal trigeminal nucleus (PrV) and its ascending projections to the forebrain. Studies addressing the cytoarchitecture and organisation of afferent input to the sensory trigeminal complex, which includes both the PrV and the nuclei of the descending trigeminal tract (nTTD), have only been performed in pigeons and ducks. Here we extend such an analysis to a songbird, the zebra finch (Taeniopygia guttata). We describe the cytoarchitecture of the sensory trigeminal complex, the patterns of calbindin-like and substance P-like immunoreactivity, and the organisation of afferents from the three branches of the trigeminal nerve and from the lingual branch of the hypoglossal nerve...
May 24, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28542626/the-relationship-between-pro-inflammatory-cytokines-and-pain-appetite-and-fatigue-in-patients-with-advanced-cancer
#12
Ørnulf Paulsen, Barry Laird, Nina Aass, Tor Lea, Peter Fayers, Stein Kaasa, Pål Klepstad
BACKGROUND: Systemic inflammation is associated with reduced quality of life and increased symptoms in patients with advanced cancer. The aims of this study were to examine the relationships between inflammatory biomarkers and the Patient Reported Outcome Measures (PROMs) of pain, appetite and fatigue; and to explore whether levels of baseline biomarkers were associated with changes in these PROMs following treatment with corticosteroids. MATERIAL AND METHODS: An exploratory analysis was done on a trial examining the analgesic properties of corticosteroids in patients with advanced cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28542465/employers-perception-of-the-costs-and-the-benefits-of-hiring-individuals-with-autism-spectrum-disorder-in-open-employment-in-australia
#13
Melissa Scott, Andrew Jacob, Delia Hendrie, Richard Parsons, Sonya Girdler, Torbjörn Falkmer, Marita Falkmer
Research has examined the benefits and costs of employing adults with autism spectrum disorder (ASD) from the perspective of the employee, taxpayer and society, but few studies have considered the employer perspective. This study examines the benefits and costs of employing adults with ASD, from the perspective of employers. Fifty-nine employers employing adults with ASD in open employment were asked to complete an online survey comparing employees with and without ASD on the basis of job similarity. The findings suggest that employing an adult with ASD provides benefits to employers and their organisations without incurring additional costs...
2017: PloS One
https://www.readbyqxmd.com/read/28542244/a-quantitative-label-free-analysis-of-the-extracellular-proteome-of-human-supraspinatus-tendon-reveals-damage-to-the-pericellular-and-elastic-fibre-niches-in-torn-and-aged-tissue
#14
Osnat Hakimi, Nicola Ternette, Richard Murphy, Benedikt M Kessler, Andrew Carr
Tears of the human supraspinatus tendon are common and often cause painful and debilitating loss of function. Progressive failure of the tendon leading to structural abnormality and tearing is accompanied by numerous cellular and extra-cellular matrix (ECM) changes in the tendon tissue. This proteomics study aimed to compare torn and aged rotator cuff tissue to young and healthy tissue, and provide the first ECM inventory of human supraspinatus tendon generated using label-free quantitative LC-MS/MS. Employing two digestion protocols (trypsin and elastase), we analysed grain-sized tendon supraspinatus biopsies from older patients with torn tendons and from healthy, young controls...
2017: PloS One
https://www.readbyqxmd.com/read/28541498/how-food-insecurity-could-lead-to-obesity-in-lmics-%C3%A2-when-not-enough-is-too-much-a-realist-review-of-how-food-insecurity-could-lead-to-obesity-in-low-and-middle-income-countries
#15
Penny Farrell, Anne Marie Thow, Seye Abimbola, Neha Faruqui, Joel Negin
While food insecurity is a well-known cause of under-nutrition and stunting, in recent decades it has also been linked with obesity. Understanding and thus minimising the risk factors for obesity in low- and middle-income country contexts, which often lack the health system capacity to treat the consequent obesity-related illnesses, is crucial. This study adopted realist review methodology because it enabled us to analyse and organise the evidence from low- and middle-income countries into a coherent scheme...
May 24, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28539976/a-review-of-specialist-palliative-care-provision-and-access-across-london-mapping-the-capital
#16
Sarah Cox, Fliss E M Murtagh, Adrian Tookman, Andrew Gage, Nigel Sykes, Maureen McGinn, Meeta Kathoria, Hilary Wilderspin, Liz Chart
Palliative care provision varies by diagnosis, geography, and setting. The Minimum Data-set provides high-level data on provision, but comprehensive comparative information about specialist palliative care (SPC) provision is lacking. The London Cancer Alliance - now RM Partners' Accountable Cancer Network - palliative care group (West/South London) and PallE8 (North/East London), with Marie Curie, sought to address this gap. The aim was to provide comparative data on SPC provision across London to support commissioners and providers to assess provision, identify gaps, and reduce inequity...
May 2017: London Journal of Primary Care
https://www.readbyqxmd.com/read/28539737/preclinical-toxicological-evaluation-of-idm01-the-botanical-composition-of-4-hydroxyisoleucine-and-trigonelline-based-standardized-fenugreek-seed-extract
#17
Pallavi O Deshpande, Vishwaraman Mohan, Prasad Arvind Thakurdesai
OBJECTIVE: To evaluate acute oral toxicity (AOT), subchronic (90-day repeated dose) toxicity, mutagenicity, and genotoxicity potential of IDM01, the botanical composition of 4-hydroxyisoleucine- and trigonelline-based standardized fenugreek (Trigonella foenum-graecum L) seed extract in laboratory rats. MATERIALS AND METHODS: The AOT and subchronic (90-day repeated dose) toxicity were evaluated using Sprague-Dawley rats as per the Organisation for Economic Co-operation and Development (OECD) guidelines No...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539085/journal-rankings-and-directions-for-future-research-in-health-care-management-a-global-perspective
#18
Katherine A Meese, Stephen J O'Connor, Nancy Borkowski, S Robert Hernandez
Despite the increasingly global nature of health care, much of the research about journal rankings and directions for future research in health care management is from a United States based viewpoint. There is a lack of information about influential journals and trends for health care management research from a global perspective. This exploratory study gathered the opinions of health care management researchers from 17 countries regarding which journals are considered most influential, popular research topics and areas needing more attention from the research community...
May 2017: Health Services Management Research
https://www.readbyqxmd.com/read/28538140/comparison-of-policies-for-recognising-and-responding-to-clinical-deterioration-across-five-victorian-health-services
#19
Julie Considine, Anastasia F Hutchison, Helen Rawson, Alison M Hutchinson, Tracey Bucknall, Trisha Dunning, Mari Botti, Maxine M Duke, Maryann Street
Objectives The aim of the present study was to describe and compare organisational guidance documents related to recognising and responding to clinical deterioration across five health services in Victoria, Australia.Methods Guidance documents were obtained from five health services, comprising 13 acute care hospitals, eight subacute care hospitals and approximately 5500 beds. Analysis was guided by a specific policy analysis framework and a priori themes.Results In all, 22 guidance documents and five graphic observation and response charts were reviewed...
May 25, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28537366/variation-in-methods-used-to-determine-national-mean-dmft-scores-for-12-year-old-children-in-european-countries
#20
R N Patel, K A Eaton, N B Pitts, A Schulte, K Pieper, S White
Aim: The aim of this study was to investigate the methods used to identify national mean DMFT scores for 12-year-old children in all the Member States of the European Union and European Economic Area, and in 11 other European countries. Methods: The most recent national mean DMFT scores were accessed from the World Health Organisation Oral Health CAPP and the Council of European Chief Dental Officers databanks. A literature search was then performed to access the reports of the studies that had produced these DMFT scores, cited on these databanks...
December 2016: Community Dental Health
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