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https://www.readbyqxmd.com/read/28738659/sample-treatment-in-m%C3%A3-ssbauer-spectroscopy-for-protein-related-analyses-nondestructive-possibilities-to-look-inside-metal-containing-biosystems
#1
Alexander A Kamnev, Anna V Tugarova
In this review, the unique possibilities are considered of the (57)Fe transmission (TMS) and (57)Co emission (EMS) variants of Mössbauer (nuclear γ-resonance) spectroscopy as nondestructive techniques with minimal sample preparation/treatment and a significant analytical potential, with a focus on the analysis of cation-binding sites in metalloproteins. The techniques are shown to provide unique structural and quantitative information on the coordination microenvironment, the chemical state and transformations of the Mössbauer nuclides in sophisticated metal-containing proteins, including those within complicated supramolecular structures, and in microbial cells or tissues...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738058/establishing-a-library-of-resources-to-help-people-understand-key-concepts-in-assessing-treatment-claims-the-critical-thinking-and-appraisal-resource-library-carl
#2
John C Castle, Iain Chalmers, Patricia Atkinson, Douglas Badenoch, Andrew D Oxman, Astrid Austvoll-Dahlgren, Lena Nordheim, L Kendall Krause, Lisa M Schwartz, Steven Woloshin, Amanda Burls, Paola Mosconi, Tammy Hoffmann, Leila Cusack, Loai Albarqouni, Paul Glasziou
BACKGROUND: People are frequently confronted with untrustworthy claims about the effects of treatments. Uncritical acceptance of these claims can lead to poor, and sometimes dangerous, treatment decisions, and wasted time and money. Resources to help people learn to think critically about treatment claims are scarce, and they are widely scattered. Furthermore, very few learning-resources have been assessed to see if they improve knowledge and behavior. OBJECTIVES: Our objectives were to develop the Critical thinking and Appraisal Resource Library (CARL)...
2017: PloS One
https://www.readbyqxmd.com/read/28737822/liquid-crystal-templating-as-an-approach-to-spatially-and-temporally-organise-soft-matter
#3
REVIEW
Pim van der Asdonk, Paul H J Kouwer
Chemistry quickly moves from a molecular science to a systems science. This requires spatial and temporal control over the organisation of molecules and molecular assemblies. Whilst Nature almost by default (transiently) organises her components at multiple different length scales, scientists struggle to realise even relatively straightforward patterns. In the past decades, supramolecular chemistry has taught us the rules to precisely engineer molecular assembly at the nanometre scale. At higher length scales, however, we are bound to top-down nanotechnology techniques to realise order...
July 24, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28737356/-the-hospital-patients-health-and-territories-act-and-the-recentralisation-of-the-social-and-long-term-care-sector
#4
Alain Jourdain, Jorge Muñoz, Hervé Hudebine
Hypothesis: The 2009 Hospital, Patients, Health and Territories Act crystallises a central government attempt to regain control over the social and long term care sector, which involves the utilisation of policy instruments borrowed from the hospital sector: capped budgets, agreements on targets and resources, competitive tendering or quasi-market mechanisms involving hospitals and services, etc. This paper is therefore based on the hypothesis of a recentralisation and healthicization of the social and long term care sector, with a key role for the regional health authorities...
July 10, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28737330/-mobility-of-physicians-in-europe-health-policies-and-health-care-provision
#5
Alain Jourdain, Tam Pham
: Three approaches to labour mobility are discussed: liberal, normative and ethical. The last approach appears to be the most popular by combining preservation of national interests with the World Health Organisation Global Code of Practice on the International Recruitment of Health Personnel.</ce:para>.
March 6, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28736396/using-theories-of-practice-to-understand-hiv-positive-persons-varied-engagement-with-hiv-services-a-qualitative-study-in-six-sub-saharan-african-countries
#6
Morten Skovdal, Alison Wringe, Janet Seeley, Jenny Renju, Sara Paparini, Joyce Wamoyi, Mosa Moshabela, William Ddaaki, Constance Nyamukapa, Kenneth Ondenge, Sarah Bernays, Oliver Bonnington
OBJECTIVES: This article considers the potential of 'theories of practice' for studying and understanding varied (dis)engagement with HIV care and treatment services and begins to unpack the assemblage of elements and practices that shape the nature and duration of individuals' interactions with HIV services. METHODS: We obtained data from a multicountry qualitative study that explores the use of HIV care and treatment services, with a focus on examining the social organisation of engagement with care as a practice and as manifested in the lives of people living with HIV in sub-Saharan Africa...
July 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28736332/5-hydroxytryptamine-2a-receptors-of-the-dorsal-raphe-nucleus-mediate-panic-like-behaviours-and-fear-induced-antinociception-elicited-by-neuronal-activation-in-the-central-nucleus-of-the-inferior-colliculus
#7
Raimundo da Silva Soares, Luiz Luciano Falconi-Sobrinho, Tayllon Dos Anjos-Garcia, Norberto Cysne Coimbra
It has been established that chemical stimulation of the inferior colliculus (IC) of laboratory animals evokes fear-related defensive responses, which are considered panic attack-like behaviours. In addition, there is evidence that defensive reactions provoked by chemical stimulation of midbrain tectum neurons may induce an antinociceptive response. Morphologically, the IC receives projections from other mesencephalic structures, such as the dorsal raphe nucleus (DRN), a region rich in serotonergic neurons that play a critical role in the control of defensive behaviours...
July 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28735441/pathology-of-neuroendocrine-tumours-of-the-female-genital-tract
#8
REVIEW
Brooke E Howitt, Paul Kelly, W Glenn McCluggage
Neuroendocrine tumours are uncommon or rare at all sites in the female genital tract. The 2014 World Health Organisation (WHO) Classification of neuroendocrine tumours of the endometrium, cervix, vagina and vulva has been updated with adoption of the terms low-grade neuroendocrine tumour and high-grade neuroendocrine carcinoma. In the endometrium and cervix, high-grade neoplasms are much more prevalent than low-grade and are more common in the cervix than the corpus. In the ovary, low-grade tumours are more common than high-grade carcinomas and the term carcinoid tumour is still used in WHO 2014...
September 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28734963/variability-in-elective-day-surgery-rates-between-belgian-hospitals-analyses-of-administrative-data-explained-by-surgical-experts
#9
Roos Leroy, Cécile Camberlin, Mélanie Lefèvre, Koen Van den Heede, Carine Van de Voorde, Claire Beguin
BACKGROUND: In the last decades, day surgery has steadily and significantly grown in many countries, yet the increase has been uneven. There are large variations in day-surgery activity between countries, but also within countries between hospitals and surgeons. This paper explores the variability in day-care activity for elective surgical procedures between Belgian hospitals. MATERIALS AND METHODS: The administrative hospital data of all patients formally admitted in a Belgian hospital for inpatient or day-surgery care between 2011 and 2013 were analysed and summarized in graphs...
July 19, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28734561/avoiding-adult-in-hospital-cardiac-arrest-a-retrospective-cohort-study-to-determine-preventability
#10
Gordon Bingham, Irma Bilgrami, Mandy Sandford, Sarah Larwill, Judit Orosz, Carl Luckhoff, Tony Kambourakis
INTRODUCTION: This study had three main aims. Develop a methodology for reviewing in-hospital cardiac arrests (IHCA). Assess appropriateness and potential preventability of IHCAs. Identify areas for improvement within the rapid response system (RRS). DESIGN: A retrospective cohort study of IHCA identified from an existing organisational electronic database of medical emergency (MET) and Code Blue team activation. Potential preventability of IHCA and Code Blue team activation were established by an expert panel based on a standardised case review process with descriptive and content analyses for each IHCA event...
July 19, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28734479/the-internal-medicine-of-the-21st-century-organizational-and-operational-standards
#11
E Casariego-Vales, A Zapatero-Gaviria, F J Elola-Somoza
The Spanish Society of Internal Medicine has developed a consensus document on the standards and recommendations that they consider essential to the organisation of internal medicine units for conducting their activities efficiently and with high quality. We defined 3 groups of key processes: the care of acutely ill adult patients, the comprehensive care of complex chronic patients and the examination of a patient with a difficult diagnosis and no organ-specific disease. As support processes, we identified the structure and operation of the Internal Medicine units...
July 19, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28734068/evolution-of-antero-posterior-patterning-of-the-limb-insights-from-the-chick
#12
REVIEW
Matthew Towers
The developing limbs of chicken embryos have served as pioneering models for understanding pattern formation for over a century. The ease with which chick wing and leg buds can be experimentally manipulated, while the embryo is still in the egg, has resulted in the discovery of important developmental organisers, and subsequently, the signals that they produce. Sonic hedgehog (Shh) is produced by mesenchyme cells of the polarizing region at the posterior margin of the limb bud and specifies positional values across the antero-posterior axis (the axis running from the thumb to the little finger)...
July 22, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28733657/a-gene-network-regulated-by-fgf-signalling-during-ear-development
#13
Maryam Anwar, Monica Tambalo, Ramya Ranganathan, Timothy Grocott, Andrea Streit
During development cell commitment is regulated by inductive signals that are tightly controlled in time and space. In response, cells activate specific programmes, but the transcriptional circuits that maintain cell identity in a changing signalling environment are often poorly understood. Specification of inner ear progenitors is initiated by FGF signalling. Here, we establish the genetic hierarchy downstream of FGF by systematic analysis of many ear factors combined with a network inference approach. We show that FGF rapidly activates a small circuit of transcription factors forming positive feedback loops to stabilise otic progenitor identity...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28731639/exploring-family-home-food-environments-household-resources-needed-to-utilise-weekly-deliveries-of-free-fruits-and-vegetables
#14
Sophie A Carty, Louise A Mainvil, John D Coveney
AIM: An adapted ethnographic approach was used to explore household factors that influence family fruit and vegetable consumption when access and cost barriers are removed. 'Structural' barriers, such as food affordability and accessibility, are likely to influence fruit and vegetable consumption in disadvantaged households, but households may require additional resources (human and social) to increase consumption. METHODS: Five low-income and five high-income households with children (N = 39 individuals) were observed in their home environment for three months...
April 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731502/histologic-scoring-indices-for-evaluation-of-disease-activity-in-crohn-s-disease
#15
REVIEW
Gregor Novak, Claire E Parker, Rish K Pai, John K MacDonald, Brian G Feagan, William J Sandborn, Geert D'Haens, Vipul Jairath, Reena Khanna
BACKGROUND: Histologic assessment of mucosal disease activity has been increasingly used in clinical trials of treatment for Crohn's disease. However, the operating properties of the currently existing histologic scoring indices remain unclear. OBJECTIVES: A systematic review was undertaken to evaluate the development and operating characteristics of available histologic disease activity indices in Crohn's disease. SEARCH METHODS: Electronic searches of MEDLINE, EMBASE, PubMed, and the Cochrane Library (CENTRAL) databases from inception to 20 July 2016 were supplemented by manual reviews of bibliographies and abstracts submitted to major gastroenterology meetings (Digestive Disease Week, United European Gastroenterology Week, European Crohn's and Colitis Organisation)...
July 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28730890/the-biopsychosocial-model-of-illness-a-model-whose-time-has-come
#16
Derick T Wade, Peter W Halligan
The biopsychosocial model outlined in Engel's classic Science paper four decades ago emerged from dissatisfaction with the biomedical model of illness, which remains the dominant healthcare model. Engel's call to arms for a biopsychosocial model has been taken up in several healthcare fields, but it has not been accepted in the more economically dominant and politically powerful acute medical and surgical domains. It is widely used in research into complex healthcare interventions, it is the basis of the World Health Organisation's International Classification of Functioning (WHO ICF), it is used clinically, and it is used to structure clinical guidelines...
August 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28730736/the-importance-of-moral-emotions-for-effective-collaboration-in-culturally-diverse-healthcare-teams
#17
Catherine Cook, Margaret Brunton
Moral emotions shape the effectiveness of culturally diverse teams. However, these emotions, which are integral to determining ethically responsive patient care and team relationships, typically go unrecognised. The contribution of emotions to moral deliberation is subjugated within the technorational environment of healthcare decision-making. Contemporary healthcare organisations rely on a multicultural workforce charged with the ethical care of vulnerable people. Limited extant literature examines the role of moral emotions in ethical decision-making among culturally diverse healthcare teams...
July 20, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/28730064/access-to-curriculum-for-students-with-disabilities-at-higher-education-institutions-how-does-the-national-university-of-lesotho-fare
#18
Paseka A Mosia, Nareadi Phasha
BACKGROUND: Creating access to curricula at institutions of higher education for students with disabilities requires a concerted effort from management and other key stakeholders to identify students' needs and create opportunities for success. OBJECTIVES: This paper presents the findings of a study which examined students with disabilities' access to curricula at a higher education institution in Lesotho. METHOD: Data for this qualitative study were collected using three methods: in-depth interviews, focus group discussions and document analysis...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28730062/challenges-faced-by-women-with-disabilities-in-accessing-sexual-and-reproductive-health-in-zimbabwe-the-case-of-chitungwiza-town
#19
Tafadzwa Rugoho, France Maphosa
BACKGROUND: Women with disabilities in Zimbabwe face numerous challenges in accessing sexual and reproductive health. Cultural belief still regards them as not sexually active. The government has also failed to promote policies that facilitate access to sexual and reproductive services by women with disabilities. OBJECTIVES: The reseach objectives were to explore the challenges faced by women with disabilities in accessing sexual and reproductive health in Zimbabwe...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28729635/superior-non-specific-motor-learning-in-the-blind
#20
Florence Morin-Parent, Louis de Beaumont, Hugo Théoret, Jean-Francois Lepage
It is well established that blindness induces changes in cerebral function and structure, namely affecting the somatomotor regions. However, the behavioural significance of these changes on the motor system, and on motor learning in particular, remains elusive. In this study, we used a modified version of the serial reaction time task (SRTT) with auditory cues to assess sequence specific and non-specific motor learning in blind adults and sighted controls, and compare them with sighted controls performing the classic visual SRTT...
July 20, 2017: Scientific Reports
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