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https://www.readbyqxmd.com/read/28110472/surgical-denervation-of-specific-cutaneous-nerves-impedes-excisional-wound-healing-of-small-animal-ear-pinnae
#1
Bhagwat V Alapure, Yan Lu, Hongying Peng, Song Hong
Damage to cutaneous nerves inhibits wound healing in patients. Results from animals on the nerve contributions to healing are various and sometimes contradictory. Here, we aim to clearly define the collective role of central, caudal, and rostral nerves in ear wound healing of mice, rats, and rabbits. These wounds heal with minimal contraction like wounds in humans. We resected central, caudal, and rostral nerves at the base of ear pinnae by microsurgery and created excisional full-thickness skin wounds in the pinnae neurologically downstream from the resections...
January 21, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28110319/perioperative-remote-acute-lung-injury-recent-update
#2
Jin Zhaosheng, Suen Ka Chun, Ma Daqing
Perioperative acute lung injury (ALI) is a syndrome characterised by hypoxia and chest radiograph changes. It is a serious post-operative complication, associated with considerable mortality and morbidity. In addition to mechanical ventilation, remote organ insult could also trigger systemic responses which induce ALI. Currently, there are limited treatment options available beyond conservative respiratory support. However, increasing understanding of the pathophysiology of ALI and the biochemical pathways involved will aid the development of novel treatments and help to improve patient outcome as well as to reduce cost to the health service...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28110235/relationship-between-expression-of-vascular-endothelial-growth-factor-and-the-proliferation-of-prolactinomas
#3
Nan Li Ya, ZhiQuan Jiang
OBJECTIVE: Prolactinomas are the most common functional hormone-producing pituitary lesions, accounting for 30-40% of all pituitary tumors, while in autopsy series their incidence reaches 50%. However, patients with prolactinoma had a higher recurrence percentage and rate than patients with acromegaly or Cushing's disease. Furthermore, prolactinomas have the highest rate of recurrence post-surgery as compared with other pituitary adenomas. At present, this behavior of prolactinoma is largely unexplained, but may be related to definition of cure, or to more frequent microscopic tumor infiltration into normal pituitary tissue, which is not removed at surgery...
December 14, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28110110/trauma-appraisals-emotion-regulation-difficulties-and-self-compassion-predict-posttraumatic-stress-symptoms-following-childhood-abuse
#4
M Rose Barlow, Rachel E Goldsmith Turow, James Gerhart
Experiencing traumatic events and abuse is unfortunately common in general, non-clinical samples. Recent research indicates that the ways in which individuals interpret traumatic experiences, as well as the ways that they manage challenging emotions in general, may statistically predict post-traumatic stress disorder (PTSD) symptoms to a greater extent than does trauma itself. Negative trauma appraisals, generalized emotion regulation (ER) difficulties, and low levels of self-compassion have each been shown to influence the connection between trauma exposure and subsequent PTSD symptoms...
January 18, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28110034/transcriptome-profiles-of-the-clam-meretrix-petechialis-hepatopancreas-in-response-to-vibrio-infection
#5
Fengjuan Jiang, Xin Yue, Hongxia Wang, Baozhong Liu
Microbial diseases have received much attention due to their enormous destruction of aquaculture, and Vibrio parahaemolyticus is one of the main pathogens that cause bacterial disease in the clam Meretrix petechialis. To better understand the molecular mechanisms of the immune response to Vibrio in M. petechialis, RNA-Seq was applied to explore global expression changes of hepatopancreas from this clam after Vibrio challenge. There were 199,318,966 clean reads obtained by Illumina sequencing, which were further assembled into 214,577 transcripts, and then 147,255 unigenes with an N50 of 1393 bp were identified...
January 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28110013/dna-damage-and-translational-response-during-detoxification-from-copper-exposure-in-a-wild-population-of-chironomus-riparius
#6
Paola Bernabò, Matteo Gaglio, Francesco Bellamoli, Gabriella Viero, Valeria Lencioni
Copper is one of the predominant components of pesticides employed in agriculture and known to be highly toxic once it reaches aquatic organisms. The impact of sublethal concentrations of this metal on wild insects is not yet completely understood. Studies addressing alterations in different levels of gene expression are still lacking. We previously demonstrated that in a wild population of Chironomus riparius, HSP and CYP families of genes were up-regulated at the transcriptional level after copper exposure...
January 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28109838/developmental-changes-and-day-night-expression-of-the-gonadotropin-inhibitory-hormone-system-in-the-european-sea-bass-effects-of-rearing-temperature
#7
José A Paullada-Salmerón, Guillaume Henri Loentgen, Mairi Cowan, María Aliaga-Guerrero, María Del Carmen Rendón-Unceta, José A Muñoz-Cueto
The role of rearing temperature on fish development, sex differentiation and puberty has been largely addressed, but the impact of water temperature on the ontogeny of the main neuroendocrine systems controlling reproduction has received little attention. Gonadotropin-inhibitory hormone (Gnih) has been shown to act on gonadotropin-releasing hormone (Gnrh) neurons and on the pituitary to inhibit gonadotropin release and synthesis in vertebrates, including sea bass, Dicentrarchus labrax. In the present study we investigated the effects of rearing temperature during the thermosensitive period (5-60days post-fertilization, dpf) on the expression of the Gnih gene (gnih) and its receptor (gnihr)...
January 18, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28109795/bone-morphological-effects-on-post-implantation-remodeling-of-maxillary-anterior-buccal-bone-a-clinical-and-biomechanical-study
#8
Nobuhiro Yoda, Keke Zheng, Junning Chen, Wei Li, Michael Swain, Keiichi Sasaki, Qing Li
PURPOSE: This study combines clinical investigation with finite element (FE) analysis to explore the effects of buccal bone thickness (BBT) on the morphological changes of buccal bone induced by the loaded implant. METHODS: One specific patient who had undergone an implant treatment in the anterior maxilla and experienced the buccal bone resorption on the implant was studied. Morphological changes of the bone were measured through a series of cone-beam computed tomography (CT) scans...
January 18, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28109721/inflammasome-priming-in-sterile-inflammatory-disease
#9
REVIEW
Meghana N Patel, Richard G Carroll, Silvia Galván-Peña, Evanna L Mills, Robin Olden, Martha Triantafilou, Amaya I Wolf, Clare E Bryant, Kathy Triantafilou, Seth L Masters
The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and IL-18, and drives a form of cell death known as pyroptosis. Oligomerization of this complex is actually the second step of activation, and a priming step must occur first. This involves transcriptional upregulation of pro-IL-1β, inflammasome sensor NLRP3, or the non-canonical inflammasome sensor caspase-11. An additional aspect of priming is the post-translational modification of particular inflammasome constituents...
January 18, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28109528/specific-enrichment-of-a-targeted-nitrotyrosine-containing-peptide-from-complex-matrices-and-relative-quantification-for-liquid-chromatography-mass-spectrometry-analysis
#10
Yun Yang
Protein tyrosine nitration is considered an important non-enzymatic post-translational modification. In the tyrosine nitration process, 3-nitrotyrosine is formed and recognized as a biomarker of nitrosative/nitrative stress implicated in inflammatory responses and age-related disorders. In view of the complexity of biological samples and the ultra-low abundance of protein-incorporated nitrotyrosine, selective enrichment of nitrotyrosine-containing peptides prior to chromatographic separation is crucial. Herein, I report a simple yet highly specific and efficient enrichment method for nitrotyrosine-containing peptides...
January 15, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28109506/rat-model-of-chronic-tympanic-membrane-perforation-a-longitudinal-histological-evaluation-of-underlying-mechanisms
#11
Allen Y Wang, Lawrence J Liew, Yi Shen, Jeffrey T Wang, Magnus von Unge, Marcus D Atlas, Rodney J Dilley
OBJECTIVE: To evaluate histologically the progressive development and underlying mechanisms of chronic tympanic membrane perforation (TMP) in a rat model using a two-weeks ventilation tube (VT) treatment combined with topical application of mitomycin C/dexamethasone (VT-M/D), compared with normal tympanic membrane and acute TMPs. METHODS: Fifty male Sprague-Dawley rats were divided into three experimental groups: a normal control group (n = 5), an acute TMP group (n = 5) (i...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28109505/results-of-vsb-implantation-at-the-short-process-of-the-incus-in-children-with-ear-atresia
#12
Charlotte Célérier, Briac Thierry, Cyrille Coudert, Marion Blanchard, Natalie Loundon, Erea Noel Garabédian, Françoise Denoyelle
OBJECTIVE(S): To describe a new and more simple surgical procedure for implanting the Vibrant Soundbridge (VSB) on the short process of the incus in children with ear atresia and atretic plate and present the audiometric results. METHODS: Since 2014, pre- and post-operative audiometric tests with tonal and vocal audiometryat the maximal follow up, respectively 33, 22 and 12 months were performed after VSB implantation at the ENT department, Necker Enfants Malades Hospital, Paris, France...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28108852/missing-the-target-the-neural-processing-underlying-the-omission-error
#13
Rinaldo Livio Perri, Donatella Spinelli, Francesco Di Russo
The omissions are infrequent errors consisting in missing responses to the target stimuli. This is the first study aimed at investigating the brain activities associated with omissions in a decision-making task. We recorded event-related potentials (ERPs) in 12 subjects which reported a suitable number of omissions in a visual go/no-go task. We investigated both the pre- and post-stimulus brain activities associated with correct and omitted trials. The electrical neuroimaging technique (BESA) was adopted to extract the anterior insula (aIns) activity associated with the prefrontal P2 component (pP2) peaking about 300 ms after the stimulus and reflecting the stimulus-response mapping process...
January 20, 2017: Brain Topography
https://www.readbyqxmd.com/read/28108844/cultural-identity-among-afghan-and-iraqi-traumatized-refugees-towards-a-conceptual-framework-for-mental-health-care-professionals
#14
Simon P N Groen, Annemiek Richters, Cornelis J Laban, Walter L J M Devillé
Cultural identity in relation with mental health is of growing interest in the field of transcultural psychiatry. However, there is a need to clarify the concept of cultural identity in order to make it useful in clinical practice. The purpose of this study is to unravel the complexity and many layers of cultural identity, and to assess how stress and acculturation relate to (changes in) cultural identity. As part of a larger study about cultural identity, trauma, and mental health, 85 patients from Afghanistan and Iraq in treatment for trauma-related disorders were interviewed with a Brief Cultural Interview...
January 20, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/28108180/periodontal-disease-level-butyric-acid-putatively-contributes-to-the-ageing-blood-a-proposed-link-between-periodontal-diseases-and-the-ageing-process
#15
Marni E Cueno, Keisuke Seki, Kuniyasu Ochiai, Kenichi Imai
Periodontal diseases are partly attributable to periodontopathic bacteria found in the host, whereas,butyric acid (BA) is a common secondary metabolite produced by periodontopathic bacterial pathogens.BA has been linked to oxidative stress induction while oxidative stress has long been associated with the ageing process. However, the possible link between BA-induced oxidative stress and the ageingprocess has never been elucidated. Here, we attempted to show the possible role of periodontal diseaselevel-BA (PDL-BA) in influencing the rat blood ageing process...
January 17, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28108155/association-of-health-professional-leadership-behaviors-on-health-promotion-practice-beliefs
#16
Jacqueline D Stone, Harolyn M E Belcher, Prince Attoh, Michelle D'Abundo, Tao Gong
BACKGROUND: Leadership is a process by which an individual influences a group or individual to achieve a common goal, in this case health promotion for individuals with disabilities. OBJECTIVES: (1) To examine the association between the transformational leadership behaviors of the Association of University Centers on Disabilities (AUCD) network professionals and their practice beliefs about health promotion activities, specifically cardiovascular fitness and healthy weight, for people with disabilities...
January 5, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28108059/self-views-in-social-anxiety-disorder-the-impact-of-cbt-versus-mbsr
#17
Matthew D Thurston, Philippe Goldin, Richard Heimberg, James J Gross
This study examines the impact of Cognitive-Behavioral Group Therapy (CBGT) versus Mindfulness-Based Stress Reduction (MBSR) versus Waitlist (WL) on self-views in patients with social anxiety disorder (SAD). One hundred eight unmedicated patients with SAD were randomly assigned to 12 weeks of CBGT, MBSR, or WL, and completed a self-referential encoding task (SRET) that assessed self-endorsement of positive and negative self-views pre- and post-treatment. At baseline, 40 healthy controls (HCs) also completed the SRET...
January 10, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28107990/combined-use-of-peptide-ion-and-normalized-delta-scores-to-evaluate-milk-authenticity-by-ion-trap-based-proteomics-coupled-with-error-tolerant-searching
#18
Donatella Nardiello, Anna Natale, Carmen Palermo, Maurizio Quinto, Diego Centonze
A fundamental issue in proteomics is the peptide identification by database searching and the assessment of the goodness of fit between experimental and theoretical data. Despite the different number of ways to measure the quality of search results, the definition of a scoring criterion is still highly desirable in ion-trap based proteomics. Indeed, in order to fully take advantage of a low resolution MS/MS dataset, it is essential to strike a balance between greater information capture and reduced number of incorrect peptide assignments...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107985/enhanced-sensitivity-for-detection-of-plasmodium-falciparum-gametocytes-by-magnetic-nanoparticles-combined-with-enzyme-substrate-system
#19
Tienrat Tangchaikeeree, Piamsiri Sawaisorn, Sangdao Somsri, Duangporn Polpanich, Chaturong Putaporntip, Pramuan Tangboriboonrat, Rachanee Udomsangpetch, Kulachart Jangpatarapongsa
The highly sensitive and specific detection of Pfg377 gene of Plasmodium falciparum gametocyte using Magnetic Nanoparticles PCR Enzyme-Linked Gene Assay (MELGA) was successfully developed. The MELGA included amplification of the Pfg377 gene by polymerase chain reaction (PCR) using magnetic nanoparticles (MNPs)-conjugated forward primer and biotinylated reverse primer, followed by post-analytical process using horseradish peroxidase (HRP)-conjugated streptavidin (SA). The complexes of MELGA product were incubated with the peroxidase substrate and hydrogen peroxide to produce the signal for colorimetric measurement...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107975/comparison-of-sample-preparation-strategies-for-target-analysis-of-total-thyroid-hormones-levels-in-serum-by-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#20
E Álvarez, Y Madrid, M D Marazuela
This paper describes a novel method based on liquid chromatography quadrupole time-of-flight-mass spectrometry (LC-QTOF-MS) for target analysis of total THs in serum. Several sample preparation strategies have been evaluated to reduce matrix effect (namely, HybridSPE cartridges, supported liquid extraction, SLE and solid phase extraction, SPE). Deproteinization and further clean-up with mixed-mode SPE was selected as the best strategy for sample preparation, since achieved the cleanest extracts and reduced ionization suppression effects (between -11 and -24%)...
March 1, 2017: Talanta
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