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Hemeoxygenase 1

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https://www.readbyqxmd.com/read/29307774/liaison-between-heme-metabolism-and-bioenergetics-pathways-a-multimodal-elucidation-for-early-diagnosis-of-oral-cancer
#1
Ripon Sarkar, Kabita Chaterjee, Durbadal Ojha, Bijurica Chakraborty, Sanghamitra Sengupta, Debprasad Chattopadhyay, Chirasree RoyChaudhuri, Ananya Barui
Metabolic alterations of oral epithelial cells under oxidative stress are important signatures for early diagnosis of oral cancer. Amongst different metabolic alterations, non-invasive photo-diagnostic methods have been extensively used for determining cellular heme metabolism and accumulation of protoporphyrin IX (PpIX) under administration of suitable photosensitizer. In this study, we report these metabolic alterations by direct analysis of oral exfoliated cells obtained from individuals with prolonged smoking habit without the exogenous administration of any photosensitizer...
January 4, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29214688/nootkatone-confers-hepatoprotective-and-anti-fibrotic-actions-in-a-murine-model-of-liver-fibrosis-by-suppressing-oxidative-stress-inflammation-and-apoptosis
#2
Amani Kurdi, Kamal Hassan, Balaji Venkataraman, Mohanraj Rajesh
In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl4 )-induced liver fibrosis in mice. CCl4 administration elevated serum aspartate and alanine transaminases levels, respectively. In addition, CCl4 produced hepatic oxidative and nitrative stress, characterized by diminished hemeoxygenase-1 expression, antioxidant defenses, and accumulation of 4-hydroxynonenal and 3-nitrotyrosine. Furthermore, CCl4 administration evoked profound expression of pro-inflammatory cytokine expressions such as tumor necrosis factor-α, monocyte chemoattractant protein-1, and interleukin-1β in hepatic tissues, which corroborated with nuclear factor κB activation...
December 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29204750/protective-effects-of-fisetin-against-6-ohda-induced-apoptosis-by-activation-of-pi3k-akt-signaling-in-human-neuroblastoma-sh-sy5y-cells
#3
Ryoko Watanabe, Takumi Kurose, Yuta Morishige, Ko Fujimori
6-Hydroxydopamine (6-OHDA) induces the production of reactive oxygen species (ROS) that are associated with various neurodegenerative diseases such as Parkinson's disease. 3,3',4',7-Tetrahydroxyflavone (fisetin), a plant flavonoid has a variety of physiological effects such as antioxidant activity. In this study, we investigated the molecular mechanism of the neuroprotective effects of fisetin against 6-OHDA-induced cell death in human neuroblastoma SH-SY5Y cells. 6-OHDA-mediated cell toxicity was reduced in a fisetin concentration-dependent manner...
December 4, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29203962/sake-lees-hydrolysate-protects-against-acetaminophen-induced-hepatotoxicity-via-activation-of-the-nrf2-antioxidant-pathway
#4
Kayoko Kawakami, Chie Moritani, Misugi Uraji, Akiko Fujita, Koji Kawakami, Tadashi Hatanaka, Etsuko Suzaki, Seiji Tsuboi
Acetaminophen is a commonly used analgesic. However, an overdose of acetaminophen causes severe hepatotoxicity via depletion of hepatic glutathione. Here, we investigated the protective effects of sake lees hydrolysate against acetaminophen-induced hepatotoxicity in mice. Sake lees hydrolysate was administered orally to ICR mice for seven days. Six hours after acetaminophen treatment, the mice were sacrificed, and blood and liver samples were collected for analysis. Treatment with acetaminophen markedly increased the levels of serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase...
November 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29191728/the-sp2-iminosugar-glycolipid-1-dodecylsulfonyl-5n-6o-oxomethylidenenojirimycin-dso2-onj-as-selective-anti-inflammatory-agent-by-modulation-of-hemeoxygenase-1-in-bv-2-microglial-cells-and-retinal-explants
#5
Elena Alcalde-Estévez, Ana I Arroba, Elena M Sánchez-Fernández, Carmen Ortiz Mellet, Jose M García Fernández, Laura Masgrau, Ángela M Valverde
Neuroinflammation is an early event during diabetic retinopathy (DR) that impacts the dynamics of microglia polarization. Gliosis is a hallmark of DR and we have reported the beneficial effects of 1R-DSO-ONJ, a member of the sp2-iminosugar glycolipid (sp2-IGL) family, in targeting microglia and reducing gliosis in diabetic db/db mice. Herein, we analyzed the effect of DSO2-ONJ, another family compound incorporating a sulfone group that better mimics the phosphate group of phosphatidylinositol ether lipid analogues (PIAs), in Bv...
November 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29162986/hyperoside-attenuates-dextran-sulfate-sodium-induced-colitis-in-mice-possibly-via-activation-of-the-nrf2-signalling-pathway
#6
Lei Yang, Lei Shen, Yue Li, Yanxia Li, Shijie Yu, Shanshan Wang
Background: Hyperoside (Hyp) is a flavonoid glycoside compound that has been demonstrated to have anti-inflammatory, anti-apoptotic and antioxidant effects. However, the impact of Hyp on inflammatory bowel disease (IBD) has not been previously explored. Thus, we evaluated the role of Hyp in dextran sodium sulfate (DSS)-induced acute colitis in mice. Methods: We established a mouse model of experimental acute colitis by treating mice with drinking water supplemented with 3...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/29138814/grape-seed-proanthocyanidin-extract-attenuates-varicocele%C3%A2-induced-testicular-oxidative-injury-in-rats-by-activating-the-nrf2%C3%A2-antioxidant-system
#7
Yong Wang, Fan Chen, Ming Liang, Shouzhen Chen, Yaofeng Zhu, Zhichuan Zou, Benkang Shi
The present study investigated whether grape seed proanthocyanidin extract (GSPE) can attenuate varicocele‑induced testicular oxidative injury through the nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) antioxidant pathway. A varicocele model in rats was established by partial ligation of the left renal vein. Following 4 weeks of GSPE administration, the decreased sperm count and motility and other pathological changes caused by varicocele were significantly alleviated, as indicated by the results of computer‑assisted sperm analysis and hematoxylin and eosin staining...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29072303/impact-of-age-on-cardiovascular-function-inflammation-and-oxidative-stress-in-experimental-asphyxial-cardiac-arrest
#8
N Secher, L Østergaard, E Tønnesen, F B Hansen, A Granfeldt
BACKGROUND: Advanced age is an independent predictor of poor outcome after cardiac arrest (CA). From experimental studies of regional ischemia-reperfusion injury, advanced age is associated with larger infarct size, reduced organ function, and augmented oxidative stress. The objective of this study was to investigate the effect of age on cardiovascular function, oxidative stress, inflammation, and endothelial activation after CA representing global ischemia-reperfusion. METHODS: Aged (26 months) and young (5 months) rats were subjected to 8 min of asphyxia induced CA, resuscitated and observed for 360 min...
January 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28931557/protective-effect-of-cyanidin-3-o-glucoside-on-neonatal-porcine-islets
#9
Chao Li, Bin Yang, Zhihao Xu, Eric Boivin, Mazzen Black, Wenlong Huang, Baoyou Xu, Ping Wu, Bo Zhang, Xian Li, Kunsong Chen, Yulian Wu, Gina R Rayat
Oxidative stress is a major cause of islet injury and dysfunction during isolation and transplantation procedures. Cyanidin-3-O-glucoside (C3G), which is present in various fruits and vegetables especially in Chinese bayberry, shows a potent antioxidant property. In this study, we determined whether C3G could protect neonatal porcine islets (NPI) from reactive oxygen species (H2O2)-induced injury in vitro and promote the function of NPI in diabetic mice. We found that C3G had no deleterious effect on NPI and that C3G protected NPI from damage induced by H2O2 Significantly higher hemeoxygenase-1 (HO1) gene expression was detected in C3G-treated NPI compared to untreated islets before and after transplantation (P < 0...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28905938/triptolide-induces-sertoli-cell-apoptosis-in-mice-via-ros-jnk-dependent-activation-of-the-mitochondrial-pathway-and-inhibition-of-nrf2-mediated-antioxidant-response
#10
Yu Wang, Su-Han Guo, Xue-Jun Shang, Li-Sha Yu, Jian-Wei Zhu, Ang Zhao, Yan-Fen Zhou, Guo-Hua An, Qi Zhang, Bo Ma
Triptolide (TP), an oxygenated diterpene, has a variety of beneficial pharmacodynamic activities but its clinical applications are restricted due to severe testicular injury. This study aimed to delineate the molecular mechanisms of TP-induced testicular injury in vitro and in vivo. TP (5-50000 nmol/L) dose-dependently decreased the viability of TM4 Sertoli cells with an IC50 value of 669.5-269.45 nmol/L at 24 h. TP (125, 250, and 500 nmol/L) dose-dependently increased the accumulation of ROS, the phosphorylation of JNK, mitochondrial dysfunction and activation of the intrinsic apoptosis pathway in TM4 cells...
September 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28902463/renoprotective-effects-of-montelukast-in-an-experimental-model-of-cisplatin-nephrotoxicity-in-rats
#11
Amany M Gad, Ola M Abd El-Raouf, Bahia M El-Sayeh, Hala M Fawzy, Dalaal M Abdallah
Renal toxicity is one of the most severe complications that can occur with cisplatin (CIS) administration in cancer patients. Montelukast (ML) renoprotective outcome contrary to CIS-drawn nephrotoxicity remains obscure. Therefore, adult male Sprague-Dawley rats were orally given ML (10 and 20 mg/kg/day) 5 days before and after single CIS (5 mg/kg; i.p.) treatment. ML returned blood urea nitrogen, as well as serum creatinine and gamma glutamyl transferase that were elevated by CIS to normal level. The improved kidney function tests corroborated the attenuation of CIS renal injury at the microscopical level...
September 13, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28861887/combination-of-quercetin-cinnamaldehyde-and-hirudin-protects-rat-dorsal-root-ganglion-neurons-against-high-glucose-induced-injury-through-nrf-2-ho-1-activation-and-nf-%C3%AE%C2%BAb-inhibition
#12
Yue Shi, Xiao-Chun Liang, Hong Zhang, Qing Sun, Qun-Li Wu, Ling Qu
OBJECTIVE: To examine the effects of the combination of quercetin (Q), cinnamaldehyde (C) and hirudin (H), a Chinese medicine formula on high glucose (HG)-induced apoptosis of cultured dorsal root ganglion (DRG) neurons. METHODS: DRG neurons exposed to HG (45 mmol/L) for 24 h were employed as an in vitro model of diabetic neuropathy. Cell viability, reactive oxygen species (ROS) level and apoptosis were determined. The expression of nuclear factor of Kappa B (NF-κB), inhibitory kappa Bα(IκBα), phosphorylated IκBα and Nf-E2 related factor 2 (Nrf2) were examined using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot assay...
September 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28842207/central-administration-of-tert-butylhydroquinone-attenuates-hypertension-via-regulating-nrf2-signaling-in-the-hypothalamic-paraventricular-nucleus-of-hypertensive-rats
#13
Juan Bai, Xiao-Jing Yu, Kai-Li Liu, Fang-Fang Wang, Gui-Xia Jing, Hong-Bao Li, Yan Zhang, Chan-Juan Huo, Xiang Li, Hong-Li Gao, Jie Qi, Yu-Ming Kang
Reactive oxygen species (ROS) in the paraventricular nucleus (PVN) play a pivotal role in the pathogenesis of hypertension. Nuclear factor E2-related factor-2 (Nrf2) is an important transcription factor that modulates cell antioxidant defense response against oxidative stress. The present study aimed to explore the efficacy of PVN administration of tert-butylhydroquinone (tBHQ), a selective Nrf2 activator, in hypertensive rats. 16-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were used in this study...
October 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28796242/the-triterpenoid-cddo-imidazolide-ameliorates-mouse-liver-ischemia-reperfusion-injury-through-activating-the-nrf2-ho-1-pathway-enhanced-autophagy
#14
Dongwei Xu, Lili Chen, Xiaosong Chen, Yankai Wen, Chang Yu, Jufang Yao, Hailong Wu, Xin Wang, Qiang Xia, Xiaoni Kong
Nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidants has been implicated to have protective roles in ischemia-reperfusion (I/R) injury in many animal models. However, the in vivo effects of CDDO-imidazole (CDDO-Im) (1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole), a Nrf2 activator, in hepatic I/R injury is lacking and its exact molecular mechanisms are still not very clear. The goals of this study were to determine whether CDDO-Im can prevent liver injury induced by I/R in the mouse, and to elucidate the molecular target of drug action...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28795139/elevated-preoperative-serum-bilirubin-improves-reperfusion-injury-and-survival-postliver-transplantation
#15
Vinzent Spetzler, Nicolas Goldaracena, Johann Moritz Kaths, Max Marquez, Markus Selzner, Nazia Selzner
BACKGROUND: The cytoprotective effects of hemeoxygenase-1 and its product biliverdin/bilirubin are widely acknowledged in experimental transplant medicine. However, its potentially beneficial effect during organ reperfusion is not established. METHODS: In a matched study, we compared markers of reperfusion injury (alanine aminotransferase/aspartate aminotransferase) and transplantation outcome (complication rates, liver function, and survival) between recipient groups with "normal" versus "increased" preoperative bilirubin values...
August 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28757373/anti-inflammatory-mechanism-of-galangin-in-lipopolysaccharide-stimulated-microglia-critical-role-of-ppar-%C3%AE-signaling-pathway
#16
Min-Ji Choi, Eun-Jung Lee, Jin-Sun Park, Su-Nam Kim, Eun-Mi Park, Hee-Sun Kim
Since microglia-associated neuroinflammation plays a pivotal role in the progression of neurodegenerative diseases, controlling microglial activation has been suggested as a potential therapeutic strategy. Here, we investigated the anti-inflammatory effects of galangin (3,5,7-trihydroxyflavone) in microglia and analyzed the underlying molecular mechanisms. Galangin inhibited the expression of inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines and enhanced the expression of anti-inflammatory interleukin (IL)-10 in lipopolysaccharide (LPS)-stimulated BV2 microglia...
November 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28740855/aldose-reductase-inhibitor-protects-against-hyperglycemic-stress-by-activating-nrf2-dependent-antioxidant-proteins
#17
Kirtikar Shukla, Pabitra Bikash Pal, Himangshu Sonowal, Satish K Srivastava, Kota V Ramana
We have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses. However, the effects of AR inhibitors on Nrf2-mediated anti-inflammatory responses have not been elucidated yet. We have investigated how AR inhibitor fidarestat protects high glucose- (HG-) induced cell viability changes by increasing the expression of Nrf2 and its dependent phase II antioxidant enzymes. Fidarestat pretreatment prevents HG (25 mM)-induced Thp1 monocyte viability...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28726208/immunolocation-of-heme-oxygenases-in-the-walls-of-cerebral-arteries-of-various-diameters-in-rats
#18
V M Chertok, A E Kotsyuba
The distribution of two enzymes involved in the formation of carbon monoxide, heme oxygenases 1 and 2, in the pial branches of orders I-V of the middle cerebral artery basin and in intracerebral vessels was studied in adult Wistar rats. Immunohistochemical studies detected hemeoxygenase-2 in the endothelium of the small pial and intracerebral arterioles and in myocytes of pial branches I-III. Heme oxygenase 1, an inducible form of the enzyme, is normally not expressed in the cerebral vessels, but the enzyme is expressed in response to sodium metaarsenite...
June 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28722058/activation-of-nrf2-are-signaling-pathway-attenuates-lanthanum-chloride-induced-injuries-in-primary-rat-astrocytes
#19
Lijin Zhang, Jinghua Yang, Shengwen Wu, Cuihong Jin, Xiaobo Lu, Xiaoyu Hu, Yaling Sun, Xiang Gao, Yuan Cai
Lanthanum (La) exposure can lead to learning and memory disorder in animals; however, the underlying mechanism of La induced neurotoxicity is still unknown. It has been demonstrated that Nrf2 activation by tert-butylhydroquinone (tBHQ) results in neuroprotection against brain injuries. However, little study has been done with respect to its effect on La induced neurotoxicity. Herein, experiments are undertaken to determine if there is a correlation between La damaged astrocytes and the Nrf2/ARE signalling pathway...
August 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28639431/decrease-in-oxidative-stress-parameters-after-post-ischaemic-recombinant-human-erythropoietin-administration-in-the-hippocampus-of-rats-exposed-to-focal-cerebral-ischaemia
#20
Jasenka Mršić-Pelčić, Kristina Pilipović, Goran Pelčić, Dinko Vitezić, Gordana Župan
Recombinant human erythropoietin (rhEpo) is a multi-functional drug with antioxidant potential. However, the underlying molecular mechanisms of its action are still unclear. The purpose of this study was to investigate the effects of rhEpo on the brain infarct volume as well as on the levels of the neuronal damage, oxidative stress parameters and active caspase-3, nuclear factor erythroid 2-related factor 2 (Nrf2) and haemeoxygenase-1 (HO-1) expressions in the hippocampi of rats exposed to the right middle cerebral artery occlusion (MCAO) for 1 hr...
June 21, 2017: Basic & Clinical Pharmacology & Toxicology
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