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Hemeoxygenase 1

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https://www.readbyqxmd.com/read/29777127/paradoxical-cardiotoxicity-of-intraperitoneally-injected-epigallocatechin-gallate-preparation-in-diabetic-mice
#1
Nora O Abdel Rasheed, Lamiaa A Ahmed, Dalaal M Abdallah, Bahia M El-Sayeh
Numerous clinical and bioavailability studies addressed epigallocatechin gallate (EGCG) beneficial effects; however, our previous work revealed EGCG-induced nephrotoxicity in the presence of diabetes. In this study, the potential myocardial toxicity of EGCG preparation (100 mg/kg/day, IP; 4 days) in diabetic mice injected with streptozotocin (STZ; 150 mg/kg, IP) was investigated. Diabetic mice receiving EGCG preparation showed electrocardiographic changes in addition to elevation of both serum creatine kinase-MB and troponin-I levels accompanied by microscopic myocardial damage...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760648/profile-of-arachidonic-acid-derived-inflammatory-markers-and-its-modulation-by-nitro-oleic-acid-in-an-inherited-model-of-amyotrophic-lateral-sclerosis
#2
Andrés Trostchansky, Mauricio Mastrogiovanni, Ernesto Miquel, Sebastián Rodríguez-Bottero, Laura Martínez-Palma, Patricia Cassina, Homero Rubbo
The lack of current treatments for amyotrophic lateral sclerosis (ALS) highlights the need of a comprehensive understanding of the biological mechanisms of the disease. A consistent neuropathological feature of ALS is the extensive inflammation around motor neurons and axonal degeneration, evidenced by accumulation of reactive astrocytes and activated microglia. Final products of inflammatory processes may be detected as a screening tool to identify treatment response. Herein, we focus on (a) detection of arachidonic acid (AA) metabolization products by lipoxygenase (LOX) and prostaglandin endoperoxide H synthase in SOD1G93A mice and (b) evaluate its response to the electrophilic nitro-oleic acid (NO2 -OA)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29731715/anti-inflammatory-effects-of-curcumin-in-microglial-cells
#3
Yangyang Yu, Qian Shen, Yihong Lai, Sun Y Park, Xingmei Ou, Dongxu Lin, Meiling Jin, Weizhen Zhang
Lipoteichoic acid (LTA) induces neuroinflammatory molecules, contributing to the pathogenesis of neurodegenerative diseases. Therefore, suppression of neuroinflammatory molecules could be developed as a therapeutic method. Although previous data supports an immune-modulating effect of curcumin, the underlying signaling pathways are largely unidentified. Here, we investigated curcumin's anti-neuroinflammatory properties in LTA-stimulated BV-2 microglial cells. Inflammatory cytokine tumor necrosis factor-α [TNF-α, prostaglandin E2 (PGE2), and Nitric Oxide (NO] secretion in LTA-induced microglial cells were inhibited by curcumin...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29713142/ketamine-ameliorates-oxidative-stress-induced-apoptosis-in-experimental-traumatic-brain-injury-via-the-nrf2-pathway
#4
Jinwei Liang, Shanhu Wu, Wenxi Xie, Hefan He
Background: Ketamine can act as a multifunctional neuroprotective agent by inhibiting oxidative stress, cellular dysfunction, and apoptosis. Although it has been proven to be effective in various neurologic disorders, the mechanism of the treatment of traumatic brain injury (TBI) is not fully understood. The aim of this study was to investigate the neuroprotective function of ketamine in models of TBI and the potential role of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in this putative protective effect...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29693172/parthenolide-inhibits-hydrogen-peroxide%C3%A2-induced-osteoblast-apoptosis
#5
Weihuan Mao, Ziguan Zhu
Parthenolide is a natural product from the shoots of Tanacetum parthenium that has been demonstrated to have immunomodulatory effects in a number of diseases. The present study aimed to determine the effect and mechanism of parthenolide on the apoptotic ability of H2O2‑induced osteoblasts. Cell viability was analyzed with a MTT assay and the apoptotic rate was subsequently measured using flow cytometry. The activity of the antioxidative enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX), and the serum marker enzymes alkaline phosphatase (ALP), malondialdehyde (MDA) and lactate dehydrogenase (LDH) was measured...
April 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29662304/chrysin-suppresses-proliferation-migration-and-invasion-in-glioblastoma-cell-lines-via-mediating-the-erk-nrf2-signaling-pathway
#6
Juan Wang, Handong Wang, Kangjian Sun, Xiaoliang Wang, Hao Pan, Jianhong Zhu, Xiangjun Ji, Xiang Li
Background: Chrysin, an active natural bioflavonoid, has been proven to protect against carcinogenesis. However, the role of chrysin in glioblastoma and the potential molecular mechanisms remain to be elucidated. In our previous study, we found that nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is highly expressed in a variety of glioblastoma cell lines associated with the mitogen-activated protein kinase (MAPK) pathway. The aim of this study was to evaluate the antitumor effects of chrysin in glioblastoma cells and how chrysin is related to the MAPK/Nrf2 signaling pathway...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29660332/dusp14-knockout-accelerates-cardiac-ischemia-reperfusion-ir-injury-through-activating-nf-%C3%AE%C2%BAb-and-mapks-signaling-pathways-modulated-by-ros-generation
#7
Bin Lin, Jing Xu, De-Guang Feng, Feng Wang, Jia-Xiang Wang, Hui Zhao
Inflammation and oxidative stress are significantly involved in the progression of a variety of diseases, including myocardial ischemia/reperfusion (IR). In the present study, we hypothesized a protective role of dual-specificity phosphatase 14 (DUSP14) in myocardial IR, as well as the underlying molecular mechanism. The results indicated that DUSP14 was down-regulated following cardiac IR injury. Subsequently, the wild type (WT) and DUSP14-knockout (KO) mice were included to further reveal the potential role of DUSP14 in cardiac IR injury progression...
May 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29617687/hemeoxygenase-1-suppresses-il-1%C3%AE-induced-apoptosis-through-the-nf-%C3%AE%C2%BAb-pathway-in-human-degenerative-nucleus-pulposus-cells
#8
Chaoying Zhu, Wei Jiang, Qiang Cheng, Zhenming Hu, Jie Hao
BACKGROUND/AIMS: Nucleus pulposus cell (NPC) apoptosis is the main factor in intervertebral disc degeneration (IDD); thus, inhibiting the excessive apoptosis of nucleus pulposus cells may be a potential way to alleviate IDD. The effect of Hemeoxygenase-1 (HO-1) on human NPC apoptosis has never been reported. Our study aimed to investigate the effect and mechanism of HO-1 on apoptosis in human degenerative NPCs. METHODS: Nucleus pulposus tissues were collected from patients with lumbar vertebral fracture (LVF) and IDD...
March 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29536989/corrigendum-1-25-dihydroxyvitamin-d-inhibits-lps-induced-high-mobility-group-box-1-hmgb1-secretion-via-targeting-the-nf-e2-related-factor-2-hemeoxygenase-1-hmgb1-pathway-in-macrophages
#9
Zebing Rao, Na Zhang, Ning Xu, Ying Pan, Mengjun Xiao, Junxian Wu, Hong Zhou, Shuo Yang, Yunzi Chen
[This corrects the article on p. 1308 in vol. 8, PMID: 29085368.].
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29526491/genetic-deletion-of-12-15-lipoxygenase-promotes-effective-resolution-of-inflammation-following-myocardial-infarction
#10
Vasundhara Kain, Kevin A Ingle, Janusz Kabarowski, Stephen Barnes, Nita A Limdi, Sumanth D Prabhu, Ganesh V Halade
12/15 lipoxygenase (LOX) directs inflammation and lipid remodeling. However, the role of 12/15LOX in post-myocardial infarction (MI) left ventricular remodeling is unclear. To determine the role of 12/15LOX, 8-12 week-old C57BL/6 J wild-type (WT; n = 93) and 12/15LOX-/- (n = 97) mice were subjected to permanent coronary artery ligation and monitored at day (d)1 and d5 post-operatively. Post-MI d28 survival was measured in male and female mice. No-MI surgery mice were maintained as d0 naïve controls...
May 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29507582/differential-effects-of-three-techniques-for-hepatic-vascular-exclusion-during-resection-for-liver-cirrhosis-on-hepatic-ischemia-reperfusion-injury-in-rats
#11
Changjun Jia, Chaoliu Dai, Hailiang Wang, Yi Wan, Yunyu Qiao, Feng Xu, Songlin Peng, Yang Zhao, Chuang Zhao, Liang Zhao
Background/Aims: Hepatic ischemia-reperfusion (I/R) injury is a serious concern during hepatic vascular occlusion. The objectives of this study were to assess effects of three techniques for hepatic vascular occlusion on I/R injury and to explore the underlying mechanisms. Methods: Liver cirrhotic rats had undertaken Pringle maneuver (PR), hemihepatic vascular occlusion (HH), or hepatic blood inflow occlusion without hemihepatic artery control (WH). Levels of tumor necrosis factor alpha (TNF- α ), nuclear factor kappa B (NF- κ B), toll-like receptor 4 (TLR4), TIR-domain-containing adapter-inducing interferon- β (TRIF), and hemeoxygenase 1 (HMOX1) were assayed...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29493155/-prevention-effect-of-ligusticum-chuanxiong-extraction-against-oxidative-stress-injury-induced-by-myocardial-ischemia-through-activation-of-nrf2-signaling-pathway
#12
Gang Wang, Ying Liu, Xue-Feng Hou, Zhong-Cheng Ke, Liang Feng, Xiao-Bin Jia
Ligusticum chuanxiong is one of the common traditional Chinese medicinal herbs for treating various cardiovascular and cerebrovascular diseases, and a number of previous studies have demonstrated that the extract of L. chuanxiong has strong antioxidative activity. This paper was mainly aimed to investigate the effects and possible mechanisms of L. chuanxiong extraction on oxidative stress induced by myocardial ischemia injury in rats. The rats were subcutaneously injected with isoprenaline hydrochloride to induce myocardial ischemia injury and treated for 2 weeks...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29469035/antifibrotic-mechanism-of-pinocembrin-impact-on-oxidative-stress-inflammation-and-tgf-%C3%AE-smad-inhibition-in-rats
#13
Marwa M Said, Samar S Azab, Noha M Saeed, Ebtehal El-Demerdash
INTRODUCTION: The present study aimed to elucidate the potential antifibrotic effects of pinocembrin (PIN), a flavanone found abundantly in honey and propolis, by studying its effect on different oxidative stress, inflammatory and fibrosis markers in an experimental model of CCl4-induced liver fibrosis. MATERIAL AND METHODS: PIN (20 mg/kg) was given orally 3 times/week for 6 consecutive weeks alternating with CCl4 (0.5 mL/kg, 1:1 mixture with corn oil, i. p.) twice weekly...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29414667/the-therapeutic-effect-of-fraxetin-on-ethanol-induced-hepatic-fibrosis-by-enhancing-ethanol-metabolism-inhibiting-oxidative-stress-and-modulating-inflammatory-mediators-in-rats
#14
Xiaowei Chen, Xiaozhou Ying, Weiming Sun, Huijia Zhu, Xin Jiang, Bin Chen
The present study was designed to investigate the possible protective effects of fraxetin against ethanol induced liver fibrosis in rats. Rats were underwent intragastric administration of ethanol (5.0-9.5 g/kg) once a day for 24 weeks. Effect of fraxetin against ethanol induced liver fibrosis was investigated by giving 20 or 50 mg/kg fraxetin. At the end of experiment, the livers were collected for histopathological analyses, protein extraction, and enzymatic activities. Our results indicated that fraxetin significantly corrected ethanol-induced hepatic fibrosis, as evidenced by the decrease in serum ALT and AST, the attenuation of histopathological changes...
March 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29411009/nrf2-activation-is-a-potential-therapeutic-approach-to-attenuate-diabetic-retinopathy
#15
Devy Deliyanti, Saeed F Alrashdi, Sih Min Tan, Colin Meyer, Keith W Ward, Judy B de Haan, Jennifer L Wilkinson-Berka
Purpose: Oxidative stress is a causal factor in the development of diabetic retinopathy; however, clinically relevant strategies to treat the disease by augmenting antioxidant defense mechanisms have not been fully explored. We hypothesized that boosting nuclear factor erythroid-2-related factor 2 (Nrf2) antioxidant capacity with the novel Nrf2 activator dh404, would protect the retina in diabetes including vision-threatening breakdown of the blood-retinal barrier (BRB) and associated damage to macroglial Müller cells...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29307774/liaison-between-heme-metabolism-and-bioenergetics-pathways-a-multimodal-elucidation-for-early-diagnosis-of-oral-cancer
#16
Ripon Sarkar, Kabita Chatterjee, Durbadal Ojha, Bijurica Chakraborty, Sanghamitra Sengupta, Debprasad Chattopadhyay, Chirasree RoyChaudhuri, Ananya Barui
Metabolic alterations of oral epithelial cells under oxidative stress are important signatures for early diagnosis of oral cancer. Amongst different metabolic alterations, non-invasive photo-diagnostic methods have been extensively used for determining cellular heme metabolism and accumulation of protoporphyrin IX (PpIX) under administration of suitable photosensitizer. In this study, we report these metabolic alterations by direct analysis of oral exfoliated cells obtained from individuals with prolonged smoking habit without the exogenous administration of any photosensitizer...
March 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29214688/nootkatone-confers-hepatoprotective-and-anti-fibrotic-actions-in-a-murine-model-of-liver-fibrosis-by-suppressing-oxidative-stress-inflammation-and-apoptosis
#17
Amani Kurdi, Kamal Hassan, Balaji Venkataraman, Mohanraj Rajesh
In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl4 )-induced liver fibrosis in mice. CCl4 administration elevated serum aspartate and alanine transaminases levels, respectively. In addition, CCl4 produced hepatic oxidative and nitrative stress, characterized by diminished hemeoxygenase-1 expression, antioxidant defenses, and accumulation of 4-hydroxynonenal and 3-nitrotyrosine. Furthermore, CCl4 administration evoked profound expression of pro-inflammatory cytokine expressions such as tumor necrosis factor-α, monocyte chemoattractant protein-1, and interleukin-1β in hepatic tissues, which corroborated with nuclear factor κB activation...
February 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29204750/protective-effects-of-fisetin-against-6-ohda-induced-apoptosis-by-activation-of-pi3k-akt-signaling-in-human-neuroblastoma-sh-sy5y-cells
#18
Ryoko Watanabe, Takumi Kurose, Yuta Morishige, Ko Fujimori
6-Hydroxydopamine (6-OHDA) induces the production of reactive oxygen species (ROS) that are associated with various neurodegenerative diseases such as Parkinson's disease. 3,3',4',7-Tetrahydroxyflavone (fisetin), a plant flavonoid has a variety of physiological effects such as antioxidant activity. In this study, we investigated the molecular mechanism of the neuroprotective effects of fisetin against 6-OHDA-induced cell death in human neuroblastoma SH-SY5Y cells. 6-OHDA-mediated cell toxicity was reduced in a fisetin concentration-dependent manner...
February 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29203962/sake-lees-hydrolysate-protects-against-acetaminophen-induced-hepatotoxicity-via-activation-of-the-nrf2-antioxidant-pathway
#19
Kayoko Kawakami, Chie Moritani, Misugi Uraji, Akiko Fujita, Koji Kawakami, Tadashi Hatanaka, Etsuko Suzaki, Seiji Tsuboi
Acetaminophen is a commonly used analgesic. However, an overdose of acetaminophen causes severe hepatotoxicity via depletion of hepatic glutathione. Here, we investigated the protective effects of sake lees hydrolysate against acetaminophen-induced hepatotoxicity in mice. Sake lees hydrolysate was administered orally to ICR mice for seven days. Six hours after acetaminophen treatment, the mice were sacrificed, and blood and liver samples were collected for analysis. Treatment with acetaminophen markedly increased the levels of serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase...
November 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29191728/the-sp-2-iminosugar-glycolipid-1-dodecylsulfonyl-5n-6o-oxomethylidenenojirimycin-dso-2-onj-as-selective-anti-inflammatory-agent-by-modulation-of-hemeoxygenase-1-in-bv-2-microglial-cells-and-retinal-explants
#20
Elena Alcalde-Estévez, Ana I Arroba, Elena M Sánchez-Fernández, Carmen Ortiz Mellet, Jose M García Fernández, Laura Masgrau, Ángela M Valverde
Neuroinflammation is an early event during diabetic retinopathy (DR) that impacts the dynamics of microglia polarization. Gliosis is a hallmark of DR and we have reported the beneficial effects of 1R-DSO-ONJ, a member of the sp2 -iminosugar glycolipid (sp2 -IGL) family, in targeting microglia and reducing gliosis in diabetic db/db mice. Herein, we analyzed the effect of DSO2 -ONJ, another family compound incorporating a sulfone group that better mimics the phosphate group of phosphatidylinositol ether lipid analogues (PIAs), in Bv...
January 2018: Food and Chemical Toxicology
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