keyword
MENU ▼
Read by QxMD icon Read
search

Vernal keratoconjunctivitis

keyword
https://www.readbyqxmd.com/read/27909980/omalizumab-in-severe-refractory-vernal-keratoconjunctivitis-in-children-case-series-and-review-of-the-literature
#1
Serge Doan, Flore Amat, Eric Gabison, Sarah Saf, Isabelle Cochereau, Jocelyne Just
INTRODUCTION: Vernal keratoconjunctivis (VKC) is a severe form of pediatric ocular allergy, characterized by acute and chronic corneoconjunctival inflammation that may lead to visual sequelae. Although topical immunosuppressive drugs such as cyclosporine are usually effective, some severe forms may be refractory and require prolonged steroid therapy. Very few papers report the use of omalizumab in VKC in the literature. In the present study, we describe our clinical experience with omalizumab in severe VKC children...
December 1, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27897453/clinical-usefulness-of-simultaneous-measurement-of-the-tear-levels-of-ccl17-ccl24-and-il-16-for-the-biomarkers-of-allergic-conjunctival-disorders
#2
Jun Shoji, Hiroshi Aso, Noriko Inada
PURPOSE: This study investigated the clinical usefulness of a multiple tear cytokine/chemokine test by simultaneously determining tear levels of CC chemokine ligand 17 (CCL17)/thymus and activation-regulated chemokine (TARC), CCL24/eotaxin-2, and interleukin-16 (IL-16) for assessing acute and chronic allergic inflammation in allergic conjunctival disorders (ACDs). SUBJECTS AND METHODS: This study included 37 patients with ACD and 11 healthy adults (controls). Patients with ACDs were divided into the following three groups; patients with allergic conjunctivitis (AC group, n = 17), patients with atopic keratoconjunctivitis (AKC group, n = 6), and patients with vernal keratoconjunctivitis (VKC group, n = 14)...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27881591/vernal-keratoconjunctivitis-culmination-of-management-using-immunosuppression-surgical-and-prosthetic-therapy-over-quarter-century
#3
Shilpa Das, Anand S Pasari, Virender S Sangwan
A 22-year-old male patient presented in 1988 with active vernal keratoconjunctivitis. He was treated with topical mast cell stabilisers and corticosteroids. Chronic inflammation despite topical treatment necessitated oral immunosuppressants. Active disease came under control with this; however, the patient gradually developed limbal stem cell deficiency. He underwent bilateral pannus resection with amniotic membrane transplantation that resulted in improved ocular surface. In 2007, patient was found to have significant bilateral posterior subcapsular cataracts and underwent bilateral cataract surgery with intraocular lens implantation with good visual outcome...
November 23, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27786545/vitamin-d-levels-in-children-affected-by-vernal-keratoconjuctivitis
#4
Anna Maria Zicari, Arianna Cafarotti, Francesca Occasi, Valeria Lollobrigida, Marcella Nebbioso, Irene Pecorella, Giovanna De Castro, Alberto Spalice, Lorenzo Loffredo, Maria Pia Villa, Marzia Duse
BACKGROUND: Vernal keratoconjunctivitis (VKC) is a chronic and often severe bilateral conjunctivitis. VKC etiology remains still unclear although endocrine, genetic, neurogenic and environmental factors have been implied. Vitamin D is a fat-soluble prohormone whose main function is the regulation of calcium and phosphate metabolism. The aim of this study was to evaluate serum vitamin D in children affected by VKC compared to the healthy children and investigate the relationship between its levels and disease severity...
October 27, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27775457/serum-vitamin-d-levels-in-children-with-vernal-keratoconjunctivitis
#5
Banu Bozkurt, Hasibe Artac, Hulya Ozdemir, Ali Ünlü, Mete Kaan Bozkurt, Murat Irkec
PURPOSE: To evaluate serum 25-hydroxyvitamin D [25(OH)D3] levels of vernal keratoconjunctivitis (VKC) children. METHODS: A total of 62 non-atopic healthy children (64.5% male, mean age 10.79 ± 3.3 years) and 29 VKC children (75.9%, mean age 12.17 ± 2.7 years) were included in the study. Serum 25(OH)D3 levels measured by HPLC were compared between the two groups and a p value of <0.05 was considered as statistically significant. RESULTS: The mean serum 25(OH)D3 level of VKC group was significantly lower than in the control group (11...
October 24, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27721987/clinical-usefulness-of-monitoring-expression-levels-of-ccl24-eotaxin-2-mrna-on-the-ocular-surface-in-patients-with-vernal-keratoconjunctivitis-and-atopic-keratoconjunctivitis
#6
Yukiko Shiraki, Jun Shoji, Noriko Inada
Purpose. This study aimed to evaluate the clinical efficacy of using expression levels of CCL24 (eotaxin-2) mRNA on the ocular surface as a biomarker in patients with vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC). Methods. Eighteen patients with VKC or AKC (VKC/AKC group) and 12 control subjects (control group) were enrolled in this study. The VKC/AKC clinical score was determined by objective findings in patients by using the 5-5-5 exacerbation grading scale. All subjects underwent modified impression cytology and specimens were obtained from the upper tarsal conjunctiva...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27681885/prevalence-and-associated-factors-of-vernal-keratoconjunctivitis-among-children-in-gondar-city-northwest-ethiopia
#7
Dereje Hayilu, Kbrom Legesse, Natinael Lakachew, Mulusew Asferaw
BACKGROUND: Vernal keratoconjunctivitis (VKC) is a common cause of ocular morbidity in children in warm dry climates such as Sub-Saharan Africa and accounts for about 3 % of serious ophthalmic cases in tropical countries. The purpose of this study was to assess the prevalence and associated factors of vernal keratoconjunctivitis among children living in Gondar City, Ethiopia. METHODS: A Cross Sectional Design study was carried out in 737 children under the age of 18 years in Gondar City from April to May 2015...
September 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27640005/very-low-prevalence-of-keratoconus-in-a-large-series-of-vernal-keratoconjunctivitis-patients
#8
Roberto Caputo, Francesco Versaci, Neri Pucci, Cinzia de Libero, Gioia Danti, Salvatore De Masi, Rita Mencucci, Elio Novembre, Bennie H Jeng
PURPOSE: To evaluate the prevalence of keratoconus (KC) and other corneal abnormalities by means of videokeratography and tomography in a large series of patients affected by vernal keratoconjunctivitis (VKC). DESIGN: Cross-sectional study. METHODS: • Setting: Single-center, children's hospital. • Study Population: 651 consecutive patients with VKC and a control group of 500 were prospectively recruited between May 2012 and September 2013, with a minimum follow-up of 12 months...
September 14, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27504320/therapeutic-effect-of-0-1-tacrolimus-eye-ointment-in-allergic-ocular-diseases
#9
Rakesh K Barot, Satish C Shitole, Nupur Bhagat, Deepak Patil, Pawan Sawant, Kalpita Patil
INTRODUCTION: Allergic Ocular Diseases (AODs) like Atopic Keratoconjunctivitis (AKC) and Vernal Keratoconjunctivitis (VKC) are chronic forms of ocular allergy that can cause severe visual complications. Pathogenesis of AODs is uncertain and treatment has been a challenge for ophthalmologists. Tacrolimus, a 23-member cyclic macrolide lactone derived from [streptomyces tsukubaensis] now in ointment form has been successfully used in AODs. AIM: To study the therapeutic effect of 0...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27504196/expression-of-tslp-and-downstream-molecules-il-4-il-5-and-il-13-on-the-eye-surface-of-patients-with-various-types-of-allergic-conjunctivitis
#10
Xiaofen Zheng, Juan Yao, Bing Li
Background. The pathogenesis of allergic conjunctivitis has not been clearly established. Moreover, previous studies fail to consider human models of allergic conjunctivitis. This study investigated the expression of thymic stromal lymphopoiet in TSLP and its downstream molecules in conjunctival scrappings and tear. Methods. This cross-sectional study compares patients with vernal keratoconjunctivitis (VKC), seasonal allergic conjunctivitis (SAC), and perennial allergic conjunctivitis (PAC) with normal controls...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27490123/an-update-on-ocular-allergy
#11
Marcus Shaker, Erin Salcone
PURPOSE OF REVIEW: The update reviews prevalence, classification, cause, and treatment options for allergic eye disease. RECENT FINDINGS: The incidence of allergic eye disease is underreported but may affect almost all patients with allergic rhinitis. Increased rates of oculonasal symptoms have been reported in the United States resulting in significant economic expenditures. The spectrum of allergic conjunctivitis and its differential considerations include seasonal and perennial conjunctivitis, vernal and atopic keratoconjunctivitis, and giant papillary conjunctivitis...
October 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27461427/an-update-on-the-therapeutic-approach-to-vernal-keratoconjunctivitis
#12
REVIEW
Susanna Esposito, Giulia Fior, Alessandro Mori, Silvia Osnaghi, Daniele Ghiglioni
Vernal keratoconjunctivitis (VKC) is an inflammatory disease of the ocular surface. It commonly occurs in the first decade of life, has a wide geographical distribution, and usually occurs in warm, dry areas. The pathogenesis of VKC seems to have an immune, nervous, and endocrine basis. The most common eye symptoms are itching, discharge, tearing, eye irritation, redness of the eyes, and photophobia. Although VKC generally has a good prognosis, the lack of clarity regarding the origin of the disease makes treatment a challenge for pediatricians and ophthalmologists...
October 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27420560/the-study-of-interleukin-17-level-in-vernal-keratoconjunctivitis-disease-and-its-relationship-between-symptom-and-sign-severity
#13
Mohammad Hosein Validad, Hossein Ali Khazaei, Masoud Pishjoo, Zohre Safdari
INTRODUCTION: Vernal keratoconjunctivitis (VKC) is a bilateral multi-factorial disease. The pathogenesis of this disease is not obviously determined, but the role of various inflammatory cytokines has been specified. This study has provided a comparison between the level of interleukin-17 (IL17) in the serum and tears of case and control groups, and also the relationship between the level of this interleukin with severity of signs and symptoms of the disease. MATERIALS AND METHODS: This case-control study has been accomplished on 40 individuals (20 healthy people and 20 patients who suffer from VKC) in Al-Zahra Eye Center in 2014...
July 15, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27388247/case-control-study-of-risk-factors-for-acute-corneal-hydrops-in-keratoconus
#14
Allon Barsam, Nic Brennan, Harry Petrushkin, Wen Xing, Ana Quartilho, Catey Bunce, Barny Foot, Nathaniel Knox Cartwright, Anjana Haridas, Pavi Agrawal, Hanif Suleman, Sajjad Ahmad, Elisabeth MacDonald, Jennifer Johnston, Stephen Tuft
PURPOSE: To determine risk factors for the development of acute corneal hydrops in keratoconus in the UK in a case-controlled study. METHODS: Between November 2009 and December 2010, we prospectively identified 73 individuals who developed acute corneal hydrops. We then identified 174 controls from nine regions in the UK with keratoconus who had not had hydrops. For cases and controls we recorded demographics and clinical features. Univariate and multivariable logistic regressions were performed to identify risk factors...
July 7, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27330391/vitiligo-in-association-with-vernal-keratoconjunctivitis
#15
Sunil Kumar, Wajeeha Al Khars
Vernal keratoconjunctivitis (VKC) is a chronic allergic inflammation of ocular surface involving the tarsal and/or bulbar conjunctiva. Signs of VKC are confined to the conjunctiva and cornea. The skin of the lid remains uninvolved. Here we report a case of 17 year-old male suffering from VKC who develops vitiligo of lid skin and lash poliosis. All ocular and systemic causes of localized skin and lash depigmentation were excluded in our patient by thorough clinical examination and investigations. During regular follow-up for two-year patient did not develop any ocular and systemic illness presenting as vitiligo and poliosis...
April 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/27310883/tacrolimus-in-corticosteroid-refractory-vernal-keratoconjunctivitis
#16
Samrat Chatterjee, Deepshikha Agrawal
PURPOSE: To evaluate the efficacy of 0.03% tacrolimus in the treatment of corticosteroid-refractory vernal keratoconjunctivitis (VKC). METHODS: This open-label study enrolled 30 patients with VKC who were not responding to topical corticosteroid treatment for at least 4 weeks. All patients were treated with 0.03% tacrolimus eye ointment 3 times daily, 0.05% ketotifen eye drops twice daily, and preservative-free artificial tears. Symptoms (itching, redness, watering, discharge, burning, and photophobia) and signs (conjunctival injection, papillae, cobblestone papillae, limbal inflammation, or hypertrophy and corneal epithelial staining) were graded on a 4-point scale at enrolment, after 4 weeks, and at the end of treatment period, which was at 12 weeks...
June 15, 2016: Cornea
https://www.readbyqxmd.com/read/27128625/impact-of-vernal-keratoconjunctivitis-on-school-children-in-egypt
#17
Hatem M Marey, Sameh S Mandour, Osama A El Morsy, Hassan G Farahat, Shaimaa M Shokry
PURPOSE: To evaluate the prevalence of vernal keratoconjunctivitis (VKC) and its impact on school children in Egypt. METHODS: A total of 3,706 students from six randomly selected schools of Menoufia were included where 126 had symptoms according to the VKC related symptoms questionnaire. Selected children were referred to a hospital for further assessment. RESULTS: The mean age of included children was 8.79±31.87 years, with a VKC prevalence of 3...
April 29, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27125863/analysis-of-pseudoprogression-after-corneal-cross-linking-in-children-with-progressive-keratoconus
#18
Kaspar Schuerch, Christoph Tappeiner, Beatrice E Frueh
PURPOSE: To analyse the long-term efficacy of corneal cross-linking (CXL) in children with keratoconus and to describe criteria for the detection of pseudoprogression. METHODS: Evaluation of retrospectively collected corneal topography (Placido system) and tomography (Scheimpflug system) results after CXL in children (age 18 or younger). Twenty-five patients (33 eyes) were included. Follow-up was assessed after 1, 2, 3 and 4 years. Progression was defined as an increase in maximal keratometry (Kmax) of at least one dioptre (D) in 1 year...
April 29, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27103784/efficacy-and-safety-of-low-dose-topical-tacrolimus-in-vernal-keratoconjunctivitis
#19
Samir S Shoughy, Mahmoud O Jaroudi, Khalid F Tabbara
OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of topical low-dose tacrolimus (0.01%) solution in patients with vernal keratoconjunctivitis (VKC). PATIENTS AND METHODS: A total of 62 consecutive patients with VKC refractory to conventional treatment were included retrospectively. Tacrolimus 0.01% ophthalmic solution was administered to patients twice daily after discontinuation of all previous topical medications. The duration of treatment ranged from 1 month to 29 months...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27051494/allergic-conjunctival-granuloma-presenting-the-splendore-hoeppli-phenomenon-report-of-two-cases-and-review-of-literature
#20
Mansoor Shahriari, Sayed Bagher Hosseini, Roshanak Aliakbar-Navahi, Mohammad Ali Javadi, Yalda Abrishami
To report two cases of bilateral conjunctival granuloma with histopathological features of the Splendore-Hoeppli phenomenon and review of the literature. Two female patients, one with a history of pulmonary eosinophilic infiltration and another with a history of vernal keratoconjunctivitis, presented with bilateral cream to yellow colored nodules in the superior bulbar conjunctiva. Histopathologic examination revealed characteristic features of the Splendore-Hoeppli phenomenon manifesting as zones of amorphous eosinophilic material surrounded by aggregations of epithelioid histiocytes, giant cells, eosinophils and lymphoplasmacytic infiltrates...
October 2015: Journal of Ophthalmic & Vision Research
keyword
keyword
79465
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"