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Vernal keratoconjunctivitis

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https://www.readbyqxmd.com/read/29785990/continuous-intraoperative-optical-coherence-tomography-guided-shield-ulcer-debridement-with-tuck-in-multilayered-amniotic-membrane-transplantation
#1
Namrata Sharma, Deepali Singhal, Prafulla Kumar Maharana, Rahul Jain, Pranita Sahay, Jeewan S Titiyal
Purpose: The aim of this study is to describe a modified surgical technique of continuous intraoperative optical coherence tomography (iOCT)-guided shield ulcer debridement with tuck-in multilayered Amniotic membrane transplantation (ML AMT) in vernal keratoconjunctivitis (VKC) with shield ulcer with plaque. Methods: Seven eyes of seven patients presenting with VKC with shield ulcer with plaque were enrolled in this prospective case series and planned for shield ulcer debridement with ML AMT...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29610174/recalcitrant-atopic-keratoconjunctivitis-in-children-a-case-report-and-literature-review
#2
Jing Li, Xiaohui Luo, Hongmin Ke, Lingyi Liang
Atopic keratoconjunctivitis (AKC) is the most severe type of allergic conjunctivitis and may eventually lead to blindness. Although AKC is reported to be more prevalent in adults, we report a child with AKC whose clinical characteristics were not inconsistent with those typically seen in adult patients with AKC, and who was refractory to traditional topical anti-inflammatory and immunosuppressant therapies. An 11-year-old boy presented with a 3-month history of ocular redness and itching and decreased vision for a week in both eyes...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29588822/candida-albicans-endophthalmitis-following-penetrating-keratoplasty-a-case-report
#3
Shahram Bamdad, Aidin Meshksar, Mohammad Mostafa Safarpour
Endophthalmitis is one of the most serious complications of intraocular surgeries, and Candida albicans constitutes the majority of cases of post penetrating keratoplasty (PK) endophthalmitis. The presenting case is a 21-year-old woman with known case of advanced keratoconus and vernal keratoconjunctivitis who underwent PK, and developed recalcitrant anterior uveitis and subsequent whitish lesion on the superonasal of the lens. She was on topical steroids with possible impression of Uretts Zavalia syndrome versus phacoantigenic uveitis following traumatic cataract up to the 50th day of post operation that manifested symptoms of frank endophthalmitis; and underwent deep vitrectomy, lensectomy, localized iridectomy and irrigation with diluted Imipenem and Amphotericin-B...
January 2018: Electronic Physician
https://www.readbyqxmd.com/read/29552874/allergic-conjunctivitis-current-concepts-on-pathogenesis-and-management
#4
M Sacchetti, I Abicca, A Bruscolini, C Cavaliere, M Nebbioso, A Lambiase
Allergic conjunctivitis (AC) includes a wide spectrum of clinical entities characterized by different incidence, age of onset, natural course, clinical outcome and response to treatment. Taken together, they represent one of the most frequent ocular surface diseases affecting more than 30% of the young-adult population and show an increasing incidence over the years. Moreover, comorbidities with other systemic atopic conditions such as asthma, atopic dermatitis and rhinitis require a multidisciplinary approach...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29502069/galectin-3-role-in-ocular-allergy-and-potential-as-a-predictive-biomarker
#5
Frans Eberth Costa Andrade, Mab Pereira Corrêa, Alexandre Dantas Gimenes, Myrna Serapião Dos Santos, Mauro Campos, Roger Chammas, José Álvaro Pereira Gomes, Cristiane Damas Gil
AIMS: To evaluate galectin-3 (Gal-3), a β-galactoside binding protein, as a possible biomarker in ocular allergy and further investigated the role of endogenous Gal-3 in a murine model of ovalbumin (OVA)-induced allergic conjunctivitis (AC). METHODS: Conjunctival impression cytology specimens from control and patients with severe vernal keratoconjunctivitis, treated or untreated, were used to evaluate Gal-3 expression by immunocytochemistry. To investigate the mechanism of action of Gal-3, OVA-immunised BALB/c male wild-type (WT) and Gal-3 null (Gal-3-/- ) mice were challenged with eye drops containing OVA on days 14-16 with a subset of animals pretreated with 0...
March 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29466424/anterior-segment-and-external-ocular-disorders-associated-with-hiv-infections-in-the-era-of-haart-in-chiang-mai-university-hospital-a-prospective-descriptive-cross-sectional-study
#6
Tassapol Singalavanija, Somsanguan Ausayakhun, Chulaluck Tangmonkongvoragul
Human immunodeficiency virus (HIV) causes impairment to the human immune system which leads to immunocompromised conditions, including ocular complications. Several important HIV-associated disorders may involve the anterior segment, ocular surface, and adnexae organ such as dry eye, blepharitis which reduce quality of life of patients. In present, potent antiretroviral therapies HAART (highly active antiretroviral therapy) has improved the length and quality of life which may lead to an increased prevalence of anterior segment ocular disorders...
2018: PloS One
https://www.readbyqxmd.com/read/29395593/-what-about-tropical-endemic-vernal-keratoconjunctivitis-which-relationship-with-intestinal-parasites
#7
A Omgbwa Eballé, N Essomba, E Mbassi Ndocko, P Ngang, C Ebana Mvogo, A L Bella
Given the causative parasite hypothesis for tropical endemic limbo-conjunctivitis (TELC), we conducted an analytical case-control study of all children with tropical endemic limbo-conjunctivitis seen in the ophthalmology department of Laquintinie hospital in Douala during the period from January 2nd to April 30, 2015. RESULTS: We identified 64 cases of tropical endemic limbo-conjunctivitis out of 550 children seen; a hospital prevalence of 11.6%; thirteen cases (eight boys and five girls) did not meet inclusion criteria, and 51 cases were included, 31 boys (60...
February 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29391772/vernal-keratoconjunctivitis
#8
REVIEW
Hampton Addis, Bennie H Jeng
Vernal keratoconjunctivitis (VKC) is a chronic allergic conjunctivitis that is most often seen in young, males. Although most types of allergic conjunctivitis do not affect vision, VKC is unusual in that damage to the cornea from the condition can result in vision loss. Although it is typically seasonal, year-round symptoms can be seen, which can lead to uncertain diagnoses being made. Although the pathophysiology of VKC is better understood in recent years, allowing more targeted therapies, management of these patients can still be very challenging, and complications can occur...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29367201/corneal-staining-patterns-in-vernal-keratoconjunctivitis-the-new-vkc-clek-scoring-scale
#9
Andrea Leonardi, Daniela Lazzarini, Alvise La Gloria Valerio, Tania Scalora, Iva Fregona
AIM: To propose a new scoring system in the assessment of ocular surface epithelial damage in vernal keratoconjunctivitis (VKC). METHODS: 25 consecutive patients with VKC (50 eyes) were evaluated using the Quality of Life in children with VKC (QUICK) questionnaire and objective clinical measures: fluorescein and lissamine green staining and cornea confocal microscopy (Heidelberg Retina Tomography 3). Oxford, Van Bljsterweld and a new system, the VKC-Collaborative Longitudinal Evaluation of Keratoconus study (CLEK) (VKC-CLEK) scores, were used to evaluate the epithelial damage after staining...
January 24, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29338965/quality-of-life-and-clinical-characterization-of-patients-with-vernal-keratoconjunctivitis-in-a-pediatric-population-in-colombia
#10
C M Gómez-Henao, C I Herrera-Morales, R Ramírez-Giraldo, R Cardona-Villa
Vernal keratoconjunctivitis is one of the most serious ocular allergies that have the potential to induce large ocular morbidity and significant visual changes affecting the quality of life of these individuals. METHODOLOGY: This study was conducted in two phases. The first phase consisted of the clinical characterization of 32 patients from the Clinical Allergology center of the I.P.S. Universitaria from July 2014 to February 2015. A retrospective analysis of medical records was performed...
January 12, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29210839/cataract-surgery-in-ocular-surface-diseases-clinical-challenges-and-outcomes
#11
REVIEW
Virender S Sangwan, Swati Gupta, Shilpa Das
PURPOSE OF REVIEW: Cataracts are a significant cause of blindness and visual impairment worldwide. With the recent advances in cataract surgery techniques, outcomes have improved significantly in uncomplicated cases. This article discusses the challenges and outcomes of cataract surgery in complex cases targeting eyes with ocular surface diseases like Stevens-Johnson syndrome, ocular cicatricial pemphigoid, Mooren's ulcer, vernal keratoconjunctivitis and limbal stem cell deficiency. RECENT FINDINGS: Ocular surface diseases are commonly associated with corneal scarring and vascularization, conjunctival inflammation, symblepharon and forniceal shortening...
January 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29123375/sequential-keraring-implantation-and-corneal-cross-linking-for-the-treatment-of-keratoconus-in-children-with-vernal-keratoconjunctivitis
#12
Mortada A Abozaid
Purpose: The purpose of this study was to assess the safety and efficacy of femtosecond laser-assisted Keraring implantation followed by transepithelial accelerated corneal collagen cross-linking (CXL) for the treatment of keratoconus in children with vernal keratoconjunctivitis (VKC). Study design: This is a prospective interventional non-comparative case series. Patients and methods: Eighteen eyes of 11 children with keratoconus and VKC were included in this study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29118487/long-term-use-of-0-003-tacrolimus-suspension-for-treatment-of-vernal-keratoconjunctivitis
#13
Abdulrahman Mohammed Al-Amri, Sandra Flavia Fiorentini, Maan A Albarry, Ashjan Yousef Bamahfouz
PURPOSE: To evaluate the safety and efficacy of 0.003% tacrolimus suspension for the treatment of refractory vernal keratoconjunctivitis (VKC). MATERIALS AND METHODS: This prospective study included 40 eyes of 20 patients with severe VKC. After discontinuing all other medications, patients were treated with varying doses of 0.003% tacrolimus suspension. All were followed for at least 24 months. Changes in signs and symptoms after treatment were evaluated; adverse events were assessed...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29111996/microbial-keratitis-after-accelerated-corneal-collagen-cross-linking-in-keratoconus
#14
Prafulla K Maharana, Pranita Sahay, M Sujeeth, Deepali Singhal, Anubha Rathi, Jeewan S Titiyal, Namrata Sharma
PURPOSE: To assess the pattern of microbial keratitis after accelerated corneal collagen cross-linkage (aCXL) in patients with keratoconus. METHOD: The medical records of cases of keratoconus that underwent aCXL from June 2014 to May 2017 were reviewed. Cases that developed microbial keratitis after aCXL were included in the study. The clinical, microbiological profile and the treatment outcomes were evaluated. RESULTS: Of 532 eyes that underwent aCXL, 7 cases developed microbial keratitis during the study period...
February 2018: Cornea
https://www.readbyqxmd.com/read/29090512/corneal-backward-scattering-and-higher-order-aberrations-in-children-with-vernal-keratoconjunctivitis-and-normal-topography
#15
Tommy C Y Chan, Emily S Wong, Jason C K Chan, Yumeng Wang, Marco Yu, Naoyuki Maeda, Vishal Jhanji
PURPOSE: To investigate the corneal backward scattering and higher-order aberrations (HOAs) in children with vernal keratoconjunctivitis (VKC) and normal topography. METHODS: Thirty-six eyes of 22 patients with VKC and 54 eyes of 34 normal subjects were included. All participants had clear cornea, absence of dry eyes and a normal corneal tomography. Scheimpflug imaging was used to measure corneal backward scattering in zones centred on the corneal apex (central 2-mm zone and paracentral 2- to 6-mm zone), and HOAs were compared between VKC and normal control...
November 1, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29079272/modulation-of-fibroblasts-in-conjunctival-wound-healing
#16
REVIEW
Mark Zada, Ushasree Pattamatta, Andrew White
Modulating conjunctival wound healing has the potential to improve outcomes after glaucoma filtration surgery and for several ocular disorders, including ocular cicatrial pemphigoid, vernal keratoconjunctivitis, and pterygium. Although anti-inflammatories and antimetabolites have been used with success, these nonspecific agents are not without their complications. The search for novel and more targeted means to control conjunctival fibrosis without such limitations has brought much attention to the regulation of fibroblast proliferation, differentiation, extracellular matrix production, and apoptosis...
February 2018: Ophthalmology
https://www.readbyqxmd.com/read/29040121/outcomes-and-rationale-of-excision-and-mucous-membrane-grafting-in-palpebral-vernal-keratoconjunctivitis
#17
Geetha Iyer, Shweta Agarwal, Bhaskar Srinivasan
PURPOSE: To report outcomes of mucous membrane grafting (MMG) for refractory giant papillae in vernal keratoconjunctivitis. METHODS: Eleven eyes of 6 patients having giant papillae and recurrent shield ulcers refractory to topical medications, cryotherapy, and supratarsal steroid injections and shave excision of papillae underwent surgical resection of the giant papillae with MMG. Average occurrence of shield ulcers was twice per eye per year before the procedure with 50% of eyes having steroid-induced cataract and glaucoma...
February 2018: Cornea
https://www.readbyqxmd.com/read/29040120/comparative-evaluation-of-tacrolimus-versus-interferon-alpha-2b-eye-drops-in-the-treatment-of-vernal-keratoconjunctivitis-a-randomized-double-masked-study
#18
https://www.readbyqxmd.com/read/28954018/topical-tacrolimus-for-the-treatment-of-severe-allergic-keratoconjunctivitis-in-children
#19
Vera Lucia Liendo, Maria Eugenia Vola, Telma Pereira Barreiro, Tais Hitomi Wakamatsu, José Álvaro Pereira Gomes, Myrna Serapião Dos Santos
Purpose: Administration of eye drops containing antihistamines or sodium cromoglycate and its derivatives for the treatment of allergic keratoconjunctivitis is often insufficient and usually requires the addition of corticosteroids. However, the risk of complications, such as glaucoma and cataract, limits the use of corticosteroids to short courses, resulting in inadequate long-term treatment response. Immunosuppressive drugs have been considered as a valid alternative to steroids for atopic keratoconjunctivitis and vernal keratoconjunctivitis...
July 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28926887/-characteristics-of-allergic-conjunctivitis-with-positive-skin-prick-test
#20
S Yang, Y Jiang, Y M Jin, J Y Zhang, Y Li
Objective: To observe the clinical characteristics of allergic conjunctivitis, and the correlations with skin prick test results. Methods: A retrospective study. Forty patients with positive skin prick test result were included. Patients underwent an ophthalmologic examination to identify their primary presenting signs and symptoms. The allergy types were divided into 5 groups. All dates were analyzed for the dependence, normality and homogeneity of variance. Chi-square test, Mann-Whitney U test, Kruskal-Wallis H test and Spearman correlation analysis were performed accordingly...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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