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hyaluronic acid knee osteoarthritis

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https://www.readbyqxmd.com/read/29450666/recent-advances-in-hyaluronic-acid-based-therapy-for-osteoarthritis
#1
REVIEW
Steven Bowman, Mohamed E Awad, Mark W Hamrick, Monte Hunter, Sadanand Fulzele
Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the progression of the disease, but none have been shown to ubiquitously treat and cure the disease. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable or oral supplement for treatment. Hyaluronic acid (HA) is a relatively new treatment that has shown varied results through several clinical trials...
February 16, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29429372/anti-inflammatory-effects-of-intra-articular-hyaluronic-acid-a-systematic-review
#2
Roy Altman, Asheesh Bedi, Ajay Manjoo, Faizan Niazi, Peter Shaw, Philip Mease
Objective Osteoarthritis (OA) is one of the leading causes of disability in the adult population. Common nonoperative treatment options include nonsteroidal anti-inflammatory drugs (NSAIDs), intra-articular corticosteroids, and intra-articular injections of hyaluronic acid (HA). HA is found intrinsically within the knee joint providing viscoelastic properties to the synovial fluid. HA therapy provides anti-inflammatory relief through a number of different pathways, including the suppression of pro-inflammatory cytokines and chemokines...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29396701/cartilage-turnover-and-intra-articular-corticosteroid-injections-in-knee-osteoarthritis
#3
Rainer Klocke, Kirsty Levasseur, George D Kitas, Jacqueline P Smith, George Hirsch
Intra-articular corticosteroid injections (IACI) are commonly used interventions for pain relief in patients with knee osteoarthritis (OA). Biomarkers may be helpful in further elucidating how IACI exert their effect. The aim of this study is to look at the response of biomarkers of cartilage and bone metabolism after IACI in knee OA. Eighty subjects with symptomatic knee OA [45% male, mean age (SD) 64 (11) years] underwent routine knee joint injection with 40 mg triamcinolone acetonide and 4 ml 1% lignocaine...
February 2, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29388085/comparison-of-hyaluronic-acid-and-prp-intra-articular-injection-with-combined-intra-articular-and-intraosseous-prp-injections-to-treat-patients-with-knee-osteoarthritis
#4
Ke Su, Yuming Bai, Jun Wang, Haisen Zhang, Hao Liu, Shiyun Ma
The aim of this study was to evaluate the benefit provided by intraosseous infiltration combined with intra-articular injection of platelet-rich plasma to treat mild and moderate stages of knee joint degeneration (Kellgren-Lawrence score II-III) compared with other treatments, specifically intra-articular injection of PRP and of HA. Eighty-six patients with grade II to grade III knee OA according to the Kellgren-Lawrence classification were randomly assigned to intra-articular combined with intraosseous injection of PRP (group A), intra-articular PRP (group B), or intra-articular HA (group C)...
January 31, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29379312/intra-articular-ozone-or-hyaluronic-acid-injection-which-one-is-superior-in-patients-with-knee-osteoarthritis-a-6-month-randomized-clinical-trial
#5
Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Bijan Forogh, Porya Hassan Abadi, Mahsa Moridnia, Shahram Rahimi Dehgolan
Purpose: Knee osteoarthritis (OA) is a common disease, imposing a great burden through pain and decreased function. There are many therapeutic modalities including non-pharmacologic choices and oral, topical, and intra-articular medications. New studies have shown promising results for ozone application in knee OA. Our aim was to compare the effects of ozone therapy versus hyaluronic acid (HA) intra-articular injection in knee OA patients. Methods: In this randomized clinical trial, a total of 174 patients with more than 3 months of chronic pain or swelling in the knee joints along with consistent imaging findings were enrolled and randomly allocated into two groups of HA and ozone, which were planned to undergo 3 weekly injections of HA (Hyalgan®) and 10 mL of a 30 μg/mL ozone solution, respectively...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29366744/growth-factors-levels-determine-efficacy-of-platelets-rich-plasma-injection-in-knee-osteoarthritis-a-randomized-double-blind-noninferiority-trial-compared-with-viscosupplementation
#6
Marie Laure Louis, Jeremy Magalon, Elizabeth Jouve, Charles Eric Bornet, Jean Camille Mattei, Christophe Chagnaud, Alexandre Rochwerger, Julie Veran, Florence Sabatier
PURPOSE: To assess the noninferiority of a single platelet-rich plasma (PRP) injection compared with hyaluronic acid (HA), to alleviate pain and enhance functional capacity in knee osteoarthritis, and identify biological characteristics of PRP that may affect their efficacy. METHODS: Fifty-four patients with symptomatic knee osteoarthritis received a single injection of either PRP (26 patients) or HA (28 patients). They were assessed at baseline and at 1, 3, and 6 months...
January 20, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29326532/rheological-properties-of-commercially-available-hyaluronic-acid-products-in-the-united-states-for-the-treatment-of-osteoarthritis-knee-pain
#7
Mathew Nicholls, Ajay Manjoo, Peter Shaw, Faizan Niazi, Jeffrey Rosen
Objective: The inconsistent results within the current literature regarding the efficacy of intra-articular-hyaluronic acid (IA-HA) for the treatment of knee osteoarthritis (OA) have been suggested to be due to intrinsic differences between individual HA products. The purpose of this investigation is to define the rheological differences between currently available HA products in the United States at the time of this study for the treatment of knee OA, which will help elaborate on the appropriateness of classifying HA products as a class opposed to as individual agents...
2018: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29299652/hyaluronic-acid-injections-for-osteoarthritis-of-the-knee-predictors-of-successful-treatment
#8
Eric N Bowman, Justin D Hallock, Thomas W Throckmorton, Fredrick M Azar
PURPOSE: This study aimed to identify patient and treatment factors that predict a favourable response to intra-articular hyaluronic acid (HA) treatment to better guide patient and treatment selection. METHODS: This prospective, observational study evaluated patients with mild-to-moderate (Kellgren-Lawrence grades 1-3) primary knee osteoarthritis treated between March 2013 and May 2016. Patient function and pain scores were assessed by the Western Ontario and McMaster Universities Arthritis Index/Knee Injury and Osteoarthritis Outcome Score (WOMAC/KOOS) and visual analogue scale (VAS) surveys, with response to treatment defined according to the Osteoarthritis Research Society International (OARSI) 2004 criteria...
January 3, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29283898/compliance-with-the-aaos-guidelines-for-treatment-of-osteoarthritis-of-the-knee-a-survey-of-the-american-association-of-hip-and-knee-surgeons
#9
Victor Rex Carlson, Alvin Chua Ong, Fabio Ramiro Orozco, Victor Hugo Hernandez, Rex William Lutz, Zachary Douglas Post
INTRODUCTION: The American Academy of Orthopaedic Surgeons (AAOS) published a series of evidence-based guidelines for treatment of knee osteoarthritis (OA). We studied compliance with these guidelines among orthopaedic surgeons. METHODS: We sent a survey to members of the American Association of Hip and Knee Surgeons. It included five clinical vignettes based on the Kellgren-Lawrence radiographic system for classification of knee OA. Respondents selected treatment currently supported or not supported by the AAOS guidelines...
February 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29245352/effect-of-multiple-intra-articular-injections-of-polynucleotides-on-treatment-of-intractable-knee-osteoarthritis-a-case-report
#10
Jong-Uk Mun, Hyung Rae Cho, Young Soon Choi, Young Uk Kim
RATIONALE: Knee osteoarthritis (KOA) is a chronic joint degenerative disease. Intra-articular injection (IAI) of hyaluronic acid (HA) is widely used to treat KOA. However, some HA injections have no effect at all. Polynucleotides (PN) are recently noted as a valid substitute for HA. PATIENT CONCERNS: A 61-year-old female was admitted to the pain center with symptoms of pain over the knee and warmth feeling with stiffness in the left knee. The patient reported chronic severe pain in the left knee area despite 6 times IAI of HA...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29219021/review-of-the-mechanism-of-action-for-supartz-fx-in-knee-osteoarthritis
#11
Roy D Altman, Vinod Dasa, Jun Takeuchi
Objective Summarize the biologic effects of Supartz FX for knee osteoarthritis (OA), the first worldwide clinically approved intra-articular (IA) hyaluronic acid (HA) product. Design To determine the mechanism of action from preclinical and clinical studies, a literature search was conducted of Supartz FX using academic databases from 1987 to 2016. Articles on Supartz FX that deal with its mechanisms of action were extracted, categorized, and reviewed. Results Supartz FX has 2 potential mechanisms of action: (1) biomechanical: IA Supartz FX directly improves the viscoelasticity and lubrication of synovial fluid; (2) physiologic: IA Supartz FX penetrates synovium and cartilage tissues to reach HA receptors on the surface of synoviocytes and chondrocytes...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29202568/hybrid-hyaluronic-acid-versus-high-molecular-weight-hyaluronic-acid-for-the-treatment-of-osteoarthritis-in-obese-patients
#12
R Papalia, F Russo, G Torre, E Albo, V Grimaldi, G Papalia, S Sterzi, G Vadalà, F Bressi, V Denaro
Osteoarthritis (OA) of the knee is one of the most relevant and debilitating health problems. Obesity represents one of the major risk factor for early development of OA. In the obese population, knee replacement should be delayed and eventually avoided and prefer conservative treatments including intrarticular hyaluronic acid (HA) viscosupplementation. In the present clinical randomized trial, we present a comparison between two groups of 24 obese patients which were randomized to be treated with two intrarticular injections of hybrid (low and high molecular weight) hyaluronic acid (Group A) or two injections of high molecular weight hyaluronic acid (Group B)...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202561/meniscal-extrusion-as-booster-of-osteoarthritis
#13
R Papalia, G Papalia, F Russo, L A Diaz, F Bressi, S Sterzi, V Denaro
Meniscal extrusion (ME) has shown to play a critical but still unclear role in osteoarthritis (OA) development. ME has been described as an important risk factor in the progression of knee OA, as it is involved in the thinning of articular cartilage, joint space narrowing, spontaneous osteonecrosis of the knee and subchondral bone marrow lesions. Meniscal damage of any degree of severity could cause ME in both compartments, but it is commonly associated with severe meniscal tears or root tears mainly in the medial meniscus...
December 27, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29201822/effect-of-extracorporeal-shockwave-therapy-versus-intra-articular-injections-of-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#14
June-Kyung Lee, Bong-Yeon Lee, Woo-Yong Shin, Min-Ji An, Kwang-Ik Jung, Seo-Ra Yoon
Objective: To evaluate and compare the effects and outcomes of extracorporeal shock wave therapy (ESWT) and intra-articular injections of hyaluronic acid (HA) in patients with knee osteoarthritis (OA). Methods: Of the 78 patients recruited for the study, 61 patients met the inclusion criteria. The enrolled patients were randomly divided into two groups: the ESWT group and the HA group. The ESWT group underwent 3 sessions of 1,000 shockwave pulses performed on the affected knee with the dosage adjusted to 0...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29195846/association-of-fibulin-3-concentrations-with-the-presence-and-severity-of-knee-osteoarthritis-a-cross-sectional-study
#15
Qian Wu, Xuecheng Sun, Lei Du
BACKGROUND: Fibulin-3, a member of the extracellular matrix glycoproteins family, negatively regulates chondrocyte differentiation. This study aims to assess the correlation of fibulin-3 concentrations with the presence and severity of knee osteoarthritis. METHODS: This cross-sectional study was performed in a population of 209 knee osteoarthritis subjects who received hyaluronic acid treatment and 165 healthy controls. Knee osteoarthritis diagnosis was made according to the criteria of the American College of Rheumatology...
December 2017: Knee
https://www.readbyqxmd.com/read/29176264/efficacy-of-chondroitin-sulfate-for-painful-knee-osteoarthritis-a-one-year-randomized-double-blind-multicenter-clinical-study-in-japan
#16
Mitsuhiro Morita, Kotaro Yamada, Hideki Date, Kazue Hayakawa, Hidetomo Sakurai, Harumoto Yamada
We explored the effects of chondroitin sulfate on knee osteoarthritis in a one-year, randomized, double-blind, dose-comparison study. Patients with painful, Kellgren-Lawrence grade 2-3, osteoarthritis of the knee were treated with oral chondroitin sulfate at a dose of either 260 mg/day (low-dose group, control group) or 1,560 mg/day (high-dose group). Symptoms were evaluated by the Lequesne's index and visual analog scale for pain. We made subgroup analyses according to background symptom severity (Lequesne's index ≥8 or <8) in 73 patients...
November 27, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29166937/a-putative-chondroprotective-role-for-il-1%C3%AE-and-mpo-in-herbal-treatment-of-experimental-osteoarthritis
#17
Nora M Aborehab, Mahitab H El Bishbishy, Abeer Refaiy, Nermien E Waly
BACKGROUND: Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model. METHODS: Thirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Ginger and curcumin was orally administered at doses of 200 and 400 mg/kg (F200 and F400). Serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1β) and superoxide dismutase activity (SOD) were measured using ELISA...
November 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29155833/do-intra-articular-hyaluronic-acid-injections-delay-total-knee-replacement-in-patients-with-osteoarthritis-a-cox-model-analysis
#18
Angélique Delbarre, Bernard Amor, Isabelle Bardoulat, Aymeric Tetafort, Nathalie Pelletier-Fleury
OBJECTIVES: This study aimed to describe patients treated for knee osteoarthritis between 2006 and 2013 in France and to compare the delay from diagnosis to total knee replacement between patients who received intra-articular hyaluronic acid injections and those who did not receive the injections. A second objective was to compare direct medical costs for ambulatory care between treatment groups. MATERIALS AND METHODS: Patients were selected from a representative sample of the real world administrative claims database using an algorithm developed by experts from the scientific committee of the study...
2017: PloS One
https://www.readbyqxmd.com/read/29141683/pellet-coculture-of-osteoarthritic-chondrocytes-and-infrapatellar-fat-pad-derived-mesenchymal-stem-cells-with-chitosan-hyaluronic-acid-nanoparticles-promotes-chondrogenic-differentiation
#19
Shu Huang, Xiongbo Song, Tao Li, Jingfang Xiao, Yemiao Chen, Xiaoyuan Gong, Weinan Zeng, Liu Yang, Cheng Chen
BACKGROUND: Cell source plays a key role in cell-based cartilage repair and regeneration. Recent efforts in cell coculture have attempted to combine the advantages and negate the drawbacks of the constituent cell types. The aim of this study was to evaluate the chondrogenic outcome of articular chondrocytes (ACs) and infrapatellar fat pad (IPFP)-derived mesenchymal stem cells (MSCs) in direct coculture. METHODS: ACs and IPFP MSCs from the same patients with knee osteoarthritis (OA) were cocultured in monolayer and in pellets...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29114635/early-efficacy-of-intra-articular-hyadd%C3%A2-4-hymovis%C3%A2-injections-for-symptomatic-knee-osteoarthritis
#20
Ferdinando Priano
Purpose  The aim of the study was to evaluate the clinical effects of HYADD® 4, an hydrogel based on a hyaluronic acid derivative, in patients with symptomatic knee osteoarthritis, on symptoms, and joint function. Methods  This retrospective study of patients with Kellgren-Lawrence grade II to IV knee osteoarthritis (American College of Rheumatology criteria) enrolled patients who had received two infiltrations of HYADD® 4, (24 mg/3 mL) 1 week apart, and evaluated: pain at rest, pain with movement, change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score; change in nonsteroidal anti-inflammatory drugs (NSAIDs)/acetaminophen use; satisfaction with therapy; tolerability...
June 2017: Joints
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