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hyaluronic acid knee osteoarthritis

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https://www.readbyqxmd.com/read/29913441/chondroprotective-effects-of-hyaluronic-acid-chitosan-nanoparticles-containing-plasmid-dna-encoding-cytokine-response-modifier-a-in-a-rat-knee-osteoarthritis-model
#1
Pang-Hu Zhou, Bo Qiu, Rong-Hui Deng, Hua-Jie Li, Xiong-Feng Xu, Xi-Fu Shang
BACKGROUND/AIMS: Interleukin (IL)-1β plays an essential role in the pathophysiology of osteoarthritis (OA). Cytokine response modifier A (CrmA) can prevent the generation of active IL-1β. This study aimed to explore the chondroprotective effects of hyaluronic acid-chitosan nanoparticles containing plasmid DNA encoding CrmA (HA/CS-CrmA) in a rat OA model. METHODS: HA/CS-CrmA nanoparticles were synthesized through the complex coacervation of cationic polymers. The characteristics, toxicity, and transfection of the nanoparticles were investigated...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29911137/arthroscopic-partial-meniscectomy-for-painful-degenerative-meniscal-tears-in-the-presence-of-knee-osteoarthritis-in-patients-older-than-50-years-of-age-predictors-of-an-early-1-to-5-years-total-knee-replacement
#2
E Carlos Rodriguez-Merchan, Jose A Garcia-Ramos, Norma G Padilla-Eguiluz, Enrique Gomez-Barrena
Background: The role of arthroscopic partial meniscectomy (APM) for painful degenerative meniscal tears (PDMT) is currently controversial.To define the rate of early (1 to 5 years) conversion to total knee replacement (TKR) and their predictors after APM for PDMT in patients with knee osteoarthritis and more than 50 years of age. Methods: Retrospective cohort study of patients more than 50 years of age with the diagnosis of PDMT, treated by means of APM. Patients were classified in two groups: Patients that required an early (between 1 and 5 years after APM) TKR (TKR group) after its failure and patients that did not require a TKR (non-TKR group)...
May 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29909689/intra-articular-injections-in-the-treatment-of-symptoms-from-ankle-arthritis-a-systematic-review
#3
Christopher Vannabouathong, Gina Del Fabbro, Brendan Sales, Christopher Smith, Chuan Silvia Li, Darryl Yardley, Mohit Bhandari, Bradley A Petrisor
BACKGROUND: Intra-articular (IA) injections are commonly used to treat knee arthritis pain; however, whether their efficacy generalizes to ankle arthritis remains debatable. We aimed to evaluate the evidence for IA therapies in the management of this patient population. METHODS: We performed a literature search for observational and randomized controlled trials (RCTs). Treatments included corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), and mesenchymal stem cells (MSC)...
June 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29907665/longterm-effectiveness-of-intraarticular-injections-on-patient-reported-symptoms-in-knee-osteoarthritis
#4
Shao-Hsien Liu, Catherine E Dubé, Charles B Eaton, Jeffrey B Driban, Timothy E McAlindon, Kate L Lapane
OBJECTIVE: We examined the longterm effectiveness of corticosteroid or hyaluronic acid injections in relieving symptoms among persons with knee osteoarthritis (OA). METHODS: Using Osteoarthritis Initiative data, a new-user design was applied to identify participants initiating corticosteroid or hyaluronic acid injections (n = 412). Knee symptoms (pain, stiffness, function) were measured using The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29892579/intra-articular-viscosupplementation-of-hyaluronic-acids-in-an-experimental-osteoarthritis-model
#5
Marcello Zaia Oliveira, Mauro Batista Albano, Guilherme Augusto Stirma, Mario Massatomo Namba, Leandro Vidigal, Luiz Antonio Munhoz da Cunha
Objective: To analyze, from the immunohistochemical perspective, the effects of hyaluronic acid of different molecular weights in an experimental model of osteoarthritis in rabbits. Methods: Forty-four male California rabbits were randomly assigned to three different groups (PR, S, and P) and submitted to the resection of the anterior cruciate ligament of the right knee. Three weeks after the surgical procedure, three intra-articular weekly injections were carried out with low-molecular-weight native hyaluronic acid (Hyalgan® ) to PR group, high molecular weight branched chain hyaluronic acid (Synvisc® ) to group S, and saline solution 0...
May 2018: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29878617/clinical-outcomes-are-associated-with-changes-in-ultrasonographic-structural-appearance-after-platelet-rich-plasma-treatment-for-knee-osteoarthritis
#6
Hamada S Ahmad, Sherief E Farrag, Amr E Okasha, Aisha O Kadry, Tamer B Ata, Amir A Monir, Ibrahim Shady
BACKGROUND: Hyaluronic acid (HA) and platelet-rich plasma (PRP) are two treatment options used for knee osteoarthritis (KOA) but studies comparing the efficacy of the two yield conflicting results. In addition, the association of clinical outcomes of PRP intra-articular injections with changes in the ultrasonography structural appearance of the knee has not been investigated. AIM: To compare the efficacy of PRP and HA intra-articular injections as mono-therapeutic options for primary KOA, and to determine whether the clinical outcomes are associated with changes in the ultrasonography structural appearance...
May 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29851537/viscosupplementation-for-osteoarthritis-of-the-knee-a-key-opinion-leader-panel-discussion
#7
Jack Bert, Jim Kenney, Nicholas A Sgaglione, Scott McClelland, Robert Brophy, John Toth, Joseph Ruane, Yousaf Ali, Sheila Arquette, Vinod Dasa, Maria Lopes
With a sharp rise in the prevalence of osteoarthritis of the knee (OAK) in a younger population, new management strategies are needed to preserve mobility, improve patients' quality of life, and reduce the effects of potential disease-related comorbidities. Viscosupplementation with the use of hyaluronic acid (HA) injection is a treatment option for OAK that can provide lubrication and elastic shock absorption, leading to potential pain relief, improved function, and reduced stiffness. A key opinion leader (KOL) panel discussion was held December 3, 2016, with the objective of sharing opinions, ideas, information, and trends regarding OAK and the potential treatment and management offered by viscosupplementation...
June 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29849470/systematic-clinical-evidence-review-of-nasha-durolane-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#8
REVIEW
Ross Leighton, Jane Fitzpatrick, Helen Smith, Daniela Crandall, Carl R Flannery, Thierry Conrozier
Background: Pain and limitations in joint mobility associated with knee osteoarthritis (OA) are clinically challenging to manage, and advanced progression of disease can often lead to total knee arthroplasty. Intra-articular injection of hyaluronic acid (HA), also referred to as viscosupplementation, is a non-surgical treatment approach for OA, the effectiveness of which may depend on the HA composition, and the length of time over which it resides in the joint. One of the available options for such therapies includes NASHA (Durolane HA), a non-animal, biofermentation-derived product, which is manufactured using a process that stabilizes the HA molecules to slow down their rate of degradation and produce a unique formulation with a terminal half-life of ~1 month...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29789008/pharmacological-effects-of-n-2-2-2-2-6-dichlorophenyl-amino-phenyl-acetyl-oxy-ethyl-hyaluronamide-diclofenac-etalhyaluronate-si-613-a-novel-sodium-hyaluronate-derivative-chemically-linked-with-diclofenac
#9
Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda, Kenji Miyamoto
BACKGROUND: Osteoarthritis (OA) is the most common joint disorder worldwide and one of the leading causes of disability in the elderly. We have investigated the novel sodium hyaluronate derivative chemically linked with diclofenac (DF), diclofenac etalhyaluronate (SI-613), which is a potentially safer and more effective treatment for OA knee pain. In this study, we evaluated the pharmacological effects of SI-613 in experimental arthritis models. METHODS: We compared the analgesic and anti-inflammatory effects of intra-articularly administered SI-613, hyaluronic acid (HA), and of orally administered diclofenac sodium (DF-Na) in rat silver nitrate-induced arthritis model and rabbit antigen-induced arthritis model...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29779404/is-intra-articular-injection-of-synvisc-associated-with-a-delay-to-knee-arthroplasty-in-patients-with-knee-osteoarthritis
#10
Kevin L Ong, Maria Runa, Edmund Lau, Roy Altman
Objective There is debate about the effectiveness of intra-articular (IA) hyaluronic acid (HA) injections. We asked the following questions: (1) What is the epidemiology of IA HA use in knee arthroplasty (KA) patients? (2) Is Synvisc associated with a delay to KA? (3) Is there a difference in the delay to KA with the number of HA courses? Design The Optum Clinformatics data set (2006-June 2016) was used to identify patients with knee osteoarthritis (OA). Patients who did not receive IA HA were identified, along with those who received Synvisc or non-Synvisc HA...
May 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29772338/hyaluronic-acid-an-efficient-biomacromolecule-for-treatment-of-inflammatory-skin-and-joint-diseases-a-review-of-recent-developments-and-critical-appraisal-of-preclinical-and-clinical-investigations
#11
REVIEW
Li Hui Chen, Jian Feng Xue, Zhi Yong Zheng, Muhammad Shuhaidi, Hnin Ei Thu, Zahid Hussain
Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29766987/comment-on-effect-of-extracorporeal-shockwave-therapy-versus-intra-articular-injections-of-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#12
COMMENT
Valter Santilli, Federica Alviti, Marco Paoloni, Massimiliano Mangone, Andrea Bernetti
No abstract text is available yet for this article.
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29765894/in-reply-comment-on-effect-of-extracorporeal-shockwave-therapy-versus-intra-articular-injections-of-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#13
June-Kyung Lee, Bong-Yeon Lee, Woo-Yong Shin, Min-Ji An, Kwang-Ik Jung, Seo-Ra Yoon
No abstract text is available yet for this article.
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29762277/impact-of-clinical-practice-guidelines-on-use-of-intra-articular-hyaluronic-acid-and-corticosteroid-injections-for-knee-osteoarthritis
#14
Nicholas A Bedard, David E DeMik, Natalie A Glass, Robert A Burnett, Kevin J Bozic, John J Callaghan
BACKGROUND: The efficacy of corticosteroid and hyaluronic acid injections for knee osteoarthritis has been questioned. The purpose of this study was to determine the impact of the American Academy of Orthopaedic Surgeons (AAOS) clinical practice guidelines on the use of these injections in the United States and determine if utilization differed by provider specialty. METHODS: Patients with knee osteoarthritis were identified within the Humana database from 2007 to 2015, and the percentage of patients receiving a knee injection relative to the number of patients having an encounter for knee osteoarthritis was calculated and was trended for the study period...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29722575/isolated-intra-articular-injections-of-hyaluronic-acid-or-corticosteroids-or-combined-with-joint-lavage-in-patients-with-severe-hemophilic-arthropathy-of-the-knee-are-any-of-these-interventions-really-effective
#15
Emerito Carlos Rodriguez-Merchan, Leonard A Valentino
The aim of this review is to explore the scientific rationale and evidence for a potential benefit of joint lavage followed by intra-articular injection of hyaluronic acid and/or corticosteroids in patients with severe hemophilic arthropathy of the knee (SHAK). Areas covered: This article is a narrative review of the evidence for potential benefits of joint lavage followed by intra-articular injection of hyaluronic acid and corticosteroids in SHAK compared with osteoarthritis of the knee in non-hemophilia patients...
May 3, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29688920/mixed-treatment-comparisons-for-nonsurgical-treatment-of-knee-osteoarthritis-a-network-meta-analysis
#16
David S Jevsevar, Peter B Shores, Kyle Mullen, Danielle M Schulte, Gregory A Brown, Deborah S Cummins
INTRODUCTION: Knee osteoarthritis (KOA) is a significant health problem with lifetime risk of development estimated to be 45%. Effective nonsurgical treatments are needed for the management of symptoms. METHODS: We designed a network meta-analysis to determine clinically relevant effectiveness of nonsteroidal anti-inflammatory drugs, acetaminophen, intra-articular (IA) corticosteroids, IA platelet-rich plasma, and IA hyaluronic acid compared with each other as well as with oral and IA placebos...
May 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29671497/osteoarthritis-rapid-evidence-review
#17
Mark H Ebell
Osteoarthritis (OA) should be suspected in patients with pain in the fingers, shoulders, hips, knees, or ankles, especially if they are older than 40 years. Patients older than 50 years who have joint pain, minimal morning stiffness, and functional impairment likely have OA. Radiography can confirm the diagnosis and may be helpful before surgical referral, but findings generally do not correlate well with symptoms. Exercise, physical therapy, knee taping, and tai chi are beneficial for knee OA. Medical therapy provides modest benefits in pain reduction and functional improvement; however, nonsteroidal anti-inflammatory drugs, tramadol, and other opioids have significant potential harms...
April 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29658360/hyaluronic-acid-promotes-proliferation-and-migration-of-human-meniscus-cells-via-a-cd44-dependent-mechanism
#18
Tomohiko Murakami, Shuhei Otsuki, Yoshinori Okamoto, Kosuke Nakagawa, Hitoshi Wakama, Nobuhiro Okuno, Masashi Neo
PURPOSE: Treatment of meniscal injury is important for osteoarthritis (OA) prevention. Meniscus cells are divided between inner and outer cells, which have different characteristics and vascularity. We evaluated the effects of hyaluronic acid (HA) on the proliferation and migration of human inner and outer meniscus cells, and investigated the underlying healing mechanisms. MATERIALS AND METHODS: Lateral menisci from 18 patients who underwent total knee arthroplasty were used...
April 26, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29656073/protective-therapeutic-effects-of-peptide-nanofiber-and-hyaluronic-acid-hybrid-membrane-in-in-vivo-osteoarthritis-model
#19
Elif Arslan, Melis Sardan Ekiz, Cagla Eren Cimenci, Nuray Can, M Hanifi Gemci, Huseyin Ozkan, Mustafa O Guler, Ayse B Tekinay
Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan®, was used for the treatment of an osteoarthritis model, and Synvisc®, which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control...
June 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29618143/efficacy-and-safety-of-hylan-versus-hyaluronic-acid-in-the-treatment-of-knee-osteoarthritis
#20
Wen-Li Dai, Ze-Ming Lin, Dong-Hong Guo, Zhan-Jun Shi, Jian Wang
The purpose of this study was to use meta-analytic approach to compare the efficacy and safety of intraarticular hylan and hyaluronic acid (HA) for knee osteoarthritis (OA) treatment. We searched PubMed, Embase, and the Cochrane databases through July 2017 to identify Level I randomized controlled trials (RCTs) that evaluated clinical efficacy and safety of hylan compared with HA for knee OA. The primary outcomes were Visual Analogue Scale (VAS) for pain and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, and WOMAC function scores...
April 4, 2018: Journal of Knee Surgery
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