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hyaluronic acid knee osteoarthritis

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https://www.readbyqxmd.com/read/29219021/review-of-the-mechanism-of-action-for-supartz-fx-in-knee-osteoarthritis
#1
Roy D Altman, Vinod Dasa, Jun Takeuchi
Objective Summarize the biologic effects of Supartz FX for knee osteoarthritis (OA), the first worldwide clinically approved intra-articular (IA) hyaluronic acid (HA) product. Design To determine the mechanism of action from preclinical and clinical studies, a literature search was conducted of Supartz FX using academic databases from 1987 to 2016. Articles on Supartz FX that deal with its mechanisms of action were extracted, categorized, and reviewed. Results Supartz FX has 2 potential mechanisms of action: (1) biomechanical: IA Supartz FX directly improves the viscoelasticity and lubrication of synovial fluid; (2) physiologic: IA Supartz FX penetrates synovium and cartilage tissues to reach HA receptors on the surface of synoviocytes and chondrocytes...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29202568/hybrid-hyaluronic-acid-versus-high-molecular-weight-hyaluronic-acid-for-the-treatment-of-osteoarthritis-in-obese-patients
#2
R Papalia, F Russo, G Torre, E Albo, V Grimaldi, G Papalia, S Sterzi, G Vadalà, F Bressi, V Denaro
Osteoarthritis (OA) of the knee is one of the most relevant and debilitating health problems. Obesity represents one of the major risk factor for early development of OA. In the obese population, knee replacement should be delayed and eventually avoided and prefer conservative treatments including intrarticular hyaluronic acid (HA) viscosupplementation. In the present clinical randomized trial, we present a comparison between two groups of 24 obese patients which were randomized to be treated with two intrarticular injections of hybrid (low and high molecular weight) hyaluronic acid (Group A) or two injections of high molecular weight hyaluronic acid (Group B)...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202561/meniscal-extrusion-as-booster-of-osteoarthritis
#3
R Papalia, G Papalia, F Russo, L A Diaz, F Bressi, S Sterzi, V Denaro
Meniscal extrusion (ME) has shown to play a critical but still unclear role in osteoarthritis (OA) development. ME has been described as an important risk factor in the progression of knee OA, as it is involved in the thinning of articular cartilage, joint space narrowing, spontaneous osteonecrosis of the knee and subchondral bone marrow lesions. Meniscal damage of any degree of severity could cause ME in both compartments, but it is commonly associated with severe meniscal tears or root tears mainly in the medial meniscus...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29201822/effect-of-extracorporeal-shockwave-therapy-versus-intra-articular-injections-of-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#4
June-Kyung Lee, Bong-Yeon Lee, Woo-Yong Shin, Min-Ji An, Kwang-Ik Jung, Seo-Ra Yoon
Objective: To evaluate and compare the effects and outcomes of extracorporeal shock wave therapy (ESWT) and intra-articular injections of hyaluronic acid (HA) in patients with knee osteoarthritis (OA). Methods: Of the 78 patients recruited for the study, 61 patients met the inclusion criteria. The enrolled patients were randomly divided into two groups: the ESWT group and the HA group. The ESWT group underwent 3 sessions of 1,000 shockwave pulses performed on the affected knee with the dosage adjusted to 0...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29195846/association-of-fibulin-3-concentrations-with-the-presence-and-severity-of-knee-osteoarthritis-a-cross-sectional-study
#5
Qian Wu, Xuecheng Sun, Lei Du
BACKGROUND: Fibulin-3, a member of the extracellular matrix glycoproteins family, negatively regulates chondrocyte differentiation. This study aims to assess the correlation of fibulin-3 concentrations with the presence and severity of knee osteoarthritis. METHODS: This cross-sectional study was performed in a population of 209 knee osteoarthritis subjects who received hyaluronic acid treatment and 165 healthy controls. Knee osteoarthritis diagnosis was made according to the criteria of the American College of Rheumatology...
December 2017: Knee
https://www.readbyqxmd.com/read/29176264/efficacy-of-chondroitin-sulfate-for-painful-knee-osteoarthritis-a-one-year-randomized-double-blind-multicenter-clinical-study-in-japan
#6
Mitsuhiro Morita, Kotaro Yamada, Hideki Date, Kazue Hayakawa, Hidetomo Sakurai, Harumoto Yamada
We explored the effects of chondroitin sulfate on knee osteoarthritis in a one-year, randomized, double-blind, dose-comparison study. Patients with painful, Kellgren-Lawrence grade 2-3, osteoarthritis of the knee were treated with oral chondroitin sulfate at a dose of either 260 mg/day (low-dose group, control group) or 1,560 mg/day (high-dose group). Symptoms were evaluated by the Lequesne's index and visual analog scale for pain. We made subgroup analyses according to background symptom severity (Lequesne's index ≥8 or <8) in 73 patients...
November 27, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29166937/a-putative-chondroprotective-role-for-il-1%C3%AE-and-mpo-in-herbal-treatment-of-experimental-osteoarthritis
#7
Nora M Aborehab, Mahitab H El Bishbishy, Abeer Refaiy, Nermien E Waly
BACKGROUND: Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model. METHODS: Thirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Ginger and curcumin was orally administered at doses of 200 and 400 mg/kg (F200 and F400). Serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1β) and superoxide dismutase activity (SOD) were measured using ELISA...
November 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29155833/do-intra-articular-hyaluronic-acid-injections-delay-total-knee-replacement-in-patients-with-osteoarthritis-a-cox-model-analysis
#8
Angélique Delbarre, Bernard Amor, Isabelle Bardoulat, Aymeric Tetafort, Nathalie Pelletier-Fleury
OBJECTIVES: This study aimed to describe patients treated for knee osteoarthritis between 2006 and 2013 in France and to compare the delay from diagnosis to total knee replacement between patients who received intra-articular hyaluronic acid injections and those who did not receive the injections. A second objective was to compare direct medical costs for ambulatory care between treatment groups. MATERIALS AND METHODS: Patients were selected from a representative sample of the real world administrative claims database using an algorithm developed by experts from the scientific committee of the study...
2017: PloS One
https://www.readbyqxmd.com/read/29141683/pellet-coculture-of-osteoarthritic-chondrocytes-and-infrapatellar-fat-pad-derived-mesenchymal-stem-cells-with-chitosan-hyaluronic-acid-nanoparticles-promotes-chondrogenic-differentiation
#9
Shu Huang, Xiongbo Song, Tao Li, Jingfang Xiao, Yemiao Chen, Xiaoyuan Gong, Weinan Zeng, Liu Yang, Cheng Chen
BACKGROUND: Cell source plays a key role in cell-based cartilage repair and regeneration. Recent efforts in cell coculture have attempted to combine the advantages and negate the drawbacks of the constituent cell types. The aim of this study was to evaluate the chondrogenic outcome of articular chondrocytes (ACs) and infrapatellar fat pad (IPFP)-derived mesenchymal stem cells (MSCs) in direct coculture. METHODS: ACs and IPFP MSCs from the same patients with knee osteoarthritis (OA) were cocultured in monolayer and in pellets...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29114635/early-efficacy-of-intra-articular-hyadd%C3%A2-4-hymovis%C3%A2-injections-for-symptomatic-knee-osteoarthritis
#10
Ferdinando Priano
Purpose  The aim of the study was to evaluate the clinical effects of HYADD® 4, an hydrogel based on a hyaluronic acid derivative, in patients with symptomatic knee osteoarthritis, on symptoms, and joint function. Methods  This retrospective study of patients with Kellgren-Lawrence grade II to IV knee osteoarthritis (American College of Rheumatology criteria) enrolled patients who had received two infiltrations of HYADD® 4, (24 mg/3 mL) 1 week apart, and evaluated: pain at rest, pain with movement, change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score; change in nonsteroidal anti-inflammatory drugs (NSAIDs)/acetaminophen use; satisfaction with therapy; tolerability...
June 2017: Joints
https://www.readbyqxmd.com/read/29110511/decision-algorithms-for-the-retreatment-with-viscosupplementation-in-patients-suffering-from-knee-osteoarthritis-recommendations-from-the-european-viscosupplementation-consensus-group-eurovisco
#11
Raghu Raman, Yves Henrotin, Xavier Chevalier, Alberto Migliore, Jörg Jerosch, Jordi Montfort, Hervé Bard, Dominique Baron, Pascal Richette, Thierry Conrozier
Background Viscosupplementation (VS) is a symptomatic treatment of knee osteoarthritis. Although systematic reviews of its repeat use showed favorable benefit/risk ratio, no study has focused on the indication of retreatment. Methods A task force was created to look at issues regarding retreatment with VS in knee osteoarthritis. An attempt was made to reach consensus on several issues: (1) to define treatment "success" and "failure," (2) to determine when to retreat patients successfully treated by a previous VS, (3) to determine how to retreat patients in whom VS failed, (4) to define what to do in case of adverse reaction following previous VS, and (5) to examine the interests of soluble biomarkers to manage retreatment...
February 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29103324/collagen-based-porous-scaffolds-containing-plga-microspheres-for-controlled-kartogenin-release-in-cartilage-tissue-engineering
#12
Xiaomin Sun, Jianhua Wang, Yingying Wang, Qiqing Zhang
A scaffold composed of different collagen (COL)/chitosan (CS)/hyaluronic acid sodium (HAS) salt ratios was evaluated by determining porosity, swelling, loss rate in hot water, mechanical property, and cell proliferation to obtain optimum conditions for manufacturing porous scaffolds. Results showed that the optimal ratio of COL/CS/HAS salt porous scaffold was 1:1:0.1. High swelling and loss rate of scaffolds/microspheres (MPs) could lead to high diffusion rate of MPs from the scaffolds, causing an increase in the kartogenin (KGN) release...
November 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29056974/avoidance-of-total-knee-arthroplasty-in-early-osteoarthritis-of-the-knee-with-intra-articular-implantation-of-autologous-activated-peripheral-blood-stem-cells-versus-hyaluronic-acid-a-randomized-controlled-trial-with-differential-effects-of-growth-factor-addition
#13
Thana Turajane, Ukrit Chaveewanakorn, Warachaya Fongsarun, Jongjate Aojanepong, Konstantinos I Papadopoulos
In this randomized controlled trial, in early osteoarthritis (OA) that failed conservative intervention, the need for total knee arthroplasty (TKA) and WOMAC scores were evaluated, following a combination of arthroscopic microdrilling mesenchymal cell stimulation (MCS) and repeated intra-articular (IA) autologous activated peripheral blood stem cells (AAPBSCs) with growth factor addition (GFA) and hyaluronic acid (HA) versus IA-HA alone. Leukapheresis-harvested AAPBSCs were administered as three weekly IA injections combined with HA and GFA (platelet-rich plasma [PRP] and granulocyte colony-stimulating factor [hG-CSF]) and MCS in group 1 and in group 2 but without hG-CSF while group 3 received IA-HA alone...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29051707/efficacy-of-intra-articular-injection-of-a-newly-developed-plasma-rich-in-growth-factor-prgf-versus-hyaluronic-acid-on-pain-and-function-of-patients-with-knee-osteoarthritis-a-single-blinded-randomized-clinical-trial
#14
Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Azadeh Gharooee Ahangar, Porya Hassan Abadi, Parviz Mojgani, Omid Gharooi Ahangar
BACKGROUND AND OBJECTIVES: Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis. METHODS: In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29044993/intra-articular-hyaluronic-acid-injection-in-treating-knee-osteoarthritis-assessing-risk-of-bias-in-systematic-reviews-with-robis-tool
#15
Dan Xing, Bin Wang, Wei Zhang, Ziyi Yang, Yunfei Hou, Yaolong Chen, Jianhao Lin
OBJECTIVES: Intra-articular injection of hyaluronic acid (HA) is a common, yet controversial therapeutic option in treating knee osteoarthritis (OA). The purpose of the present study was to assess the risk of bias (RoB) of systematic reviews (SRs) and to summarize available evidence of HA in treating knee OA. METHODS: A systematic search of SRs published through to December 2016 was conducted using the MEDLINE, EMBASE and Cochrane Library. The RoB of included SRs was assessed by ROBIS tool...
October 17, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29040066/evaluation-of-oral-multi-herbal-preparation-of-dashmoolarishta-on-mice-model-of-osteoarthritis
#16
Yashashri C Shetty, Santosh Godbharle, Smita Brahma, Sweta Salgaonkar, Nirmala N Rege
BACKGROUND: Osteoarthritis (OA) is a chronic progressive disease commonly affecting the hip and knee joints. Although synthetic drugs are available and afford symptomatic relief, their side effects pose limitations to their continuous use. So, this research was focused on extracting drugs from indigenous medicinal plants that could have a beneficial effect on osteoarthritis. Dashmoolarishta is one such preparation whose effects have never been studied in comparison with recent drugs like hyaluronic acid (HA), hence this particular study was undertaken...
November 27, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28965100/evolution-of-pain-at-3-months-by-oral-resveratrol-in-knee-osteoarthritis-arthrol-protocol-for-a-multicentre-randomised-double-blind-placebo-controlled-trial
#17
Christelle Nguyen, Isabelle Boutron, Gabriel Baron, Emmanuel Coudeyre, Francis Berenbaum, Serge Poiraudeau, François Rannou
INTRODUCTION: Osteoarthritis (OA) pathophysiology is driven in part by joint inflammation. Resveratrol has in vitro anti-inflammatory properties. We aim to assess the efficacy of oral resveratrol for knee pain at 3 months in people with knee OA. METHODS AND ANALYSIS: We will conduct a randomised double-blind placebo-controlled trial. Overall, 164 individuals with knee OA fulfilling 1986 American College of Rheumatology criteria will be recruited in three tertiary care centres in France and randomised to receive oral resveratrol, 40 mg (two caplets) two times per day for 1 week, then 20 mg (one caplet) two times per day or a matching placebo for a total of 6 months...
September 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28946838/randomized-controlled-trial-comparing-efficacy-of-conventional-and-new-single-larger-dose-of-intra-articular-viscosupplementation-in-management-of-knee-osteoarthritis
#18
Vijaya Kumar L Suppan, Chew Yu Wei, Tan Chin Siong, Tew Mei Mei, Wong Bor Chern, Vijay Kumar Nanta Kumar, Kee Rong Sheng, Ashutosh Sadashiva Rao
BACKGROUND: Intra-articular hyaluronic acid (HA) injection is used in management of knee, hand and hip osteoarthritis. While HA injection is included in the list of evaluated therapies, its efficacy and optimum dosing still have no consensus. This study was conducted to explore the possibility of using single injection HA to increase patient convenience while maintaining the therapeutic efficacy. METHODS: We present a prospective, open label, non-blinded, randomized controlled trial performed in accordance with guidelines in principles of good clinical practice...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28937277/injectable-viscoelastic-supplements-a-review-for-radiologists
#19
REVIEW
Dermot J Bowden, Caoimhe A Byrne, Abdullah Alkhayat, Stephen J Eustace, Eoin C Kavanagh
OBJECTIVE: Hyaluronic acid (HA) is increasingly used by musculoskeletal radiologists in the treatment of osteoarthritis (OA). Although the evidence base for its efficacy is controversial, it remains in common use. With initial evidence suggesting its efficacy in the knee, it is now offered for treating OA of the hip, ankle, and elsewhere. CONCLUSION: HA is available in a wide variety of preparations, which may vary in concentration and chemical composition. Clinicians offering intraarticular HA injection should be familiar with the common preparations available and the principal differences between them, its mechanism of action, and the profile of adverse effects associated with its use...
October 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28934876/comparison-of-intra-articular-injection-of-hyaluronic-acid-and-n-acetyl-cysteine-in-the-treatment-of-knee-osteoarthritis-a-pilot-study
#20
Mustafa Ozcamdalli, Abdulhamit Misir, Turan Bilge Kizkapan, Erdal Uzun, Fuat Duygulu, Cevat Yazici, Ibrahim Halil Kafadar
Objective To compare the relative effectiveness of intra-articular N-acetyl cysteine (NAC) and hyaluronic acid (HA) on pain, function and cartilage degradation markers in patients with mild to moderate knee osteoarthritis (OA). Design We prospectively conducted a clinical trial with 20 patients having a diagnosis of Kellgren-Lawrence grade 2-3 knee OA, and randomly allocated to the HA or NAC groups. Groups were matched on age, sex, and body mass index. Injections of 3-mL HA (Hylan G-F 20) or 3-mL NAC (Asist ampoule) were administered as a single shot...
October 2017: Cartilage
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