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Maude St-Onge, Kurt Anseeuw, Frank Lee Cantrell, Ian C Gilchrist, Philippe Hantson, Benoit Bailey, Valéry Lavergne, Sophie Gosselin, William Kerns, Martin Laliberté, Eric J Lavonas, David N Juurlink, John Muscedere, Chen-Chang Yang, Tasnim Sinuff, Michael Rieder, Bruno Mégarbane
OBJECTIVE: To provide a management approach for adults with calcium channel blocker poisoning. DATA SOURCES, STUDY SELECTION, AND DATA EXTRACTION: Following the Appraisal of Guidelines for Research & Evaluation II instrument, initial voting statements were constructed based on summaries outlining the evidence, risks, and benefits. DATA SYNTHESIS: We recommend 1) for asymptomatic patients, observation and consideration of decontamination following a potentially toxic calcium channel blocker ingestion (1D); 2) as first-line therapies (prioritized based on desired effect), IV calcium (1D), high-dose insulin therapy (1D-2D), and norepinephrine and/or epinephrine (1D)...
October 3, 2016: Critical Care Medicine
David Juurlink
No abstract text is available yet for this article.
September 30, 2016: BMJ: British Medical Journal
Madhur Nayan, Erin M Macdonald, David N Juurlink, Peter C Austin, Antonio Finelli, Girish S Kulkarni, Robert J Hamilton
Survival rates in kidney cancer have improved little over time, and diabetes may be an independent risk factor for poor survival in kidney cancer. We sought to determine whether medications with putative anti-neoplastic properties (statins, metformin and non-steroidal anti-inflammatory drugs (NSAIDs)) are associated with survival in diabetics with kidney cancer. We conducted a population-based cohort study utilizing linked healthcare databases in Ontario, Canada. Patients were aged 66 or older with newly diagnosed diabetes and a subsequent diagnosis of incident kidney cancer...
September 24, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Mina Tadrous, Diana Martins, Zhan Yao, Muhammad M Mamdani, David N Juurlink, Tara Gomes, Tony Antoniou
BACKGROUND: Smoking remains a serious public health concern. Pharmacotherapy for smoking cessation, including bupropion and varenicline, are proven means to increase quit rates. Post-marketing reports describing suicidal behaviours have raised concerns about the safety of varenicline. However, whether varenicline imparts a higher risk of suicide relative to bupropion remains uncertain. METHODS: A population-based nested case-control study in Ontario, Canada, from April 1, 2011 to March 31, 2015 was conducted...
2016: PloS One
Diana Martins, Zhan Yao, Mina Tadrous, Baiju R Shah, David N Juurlink, Muhammad M Mamdani, Tara Gomes
PURPOSE: To examine the concordance between testosterone replacement therapy (TRT) use and established reimbursement criteria, as well as compare the persistence of use among available formulations (injectable, oral, topical gel, transdermal patch) among elderly men in Ontario, Canada. METHODS: We conducted a retrospective cohort study of men aged 66 years or older in Ontario newly treated with testosterone between 1 January 2009 and 31 December 2012 using linked health administrative data...
August 16, 2016: Pharmacoepidemiology and Drug Safety
Sarah A Buchan, Laura C Rosella, Michael Finkelstein, David Juurlink, Jennifer Isenor, Fawziah Marra, Anik Patel, Margaret L Russell, Susan Quach, Nancy Waite, Jeffrey C Kwong
BACKGROUND: Uptake of influenza vaccination in Canada remains suboptimal despite widespread public funding. To increase access, several provinces have implemented policies permitting pharmacists to administer influenza vaccines in community pharmacies. We examined the impact of such policies on the uptake of seasonal influenza vaccination in Canada. METHODS: We pooled data from the 2007-2014 cycles of the Canadian Community Health Survey (n = 481 526). To determine the impact of influenza vaccine administration by pharmacists, we estimated the prevalence ratio for the association between the presence of a pharmacist policy and individual-level vaccine uptake using a modified Poisson regression model (dependent variable: vaccine uptake) with normalized weights while controlling for numerous health and sociodemographic factors...
August 8, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Laurent Azoulay, Kristian B Filion, Robert W Platt, Matthew Dahl, Colin R Dormuth, Kristin K Clemens, Madeleine Durand, Nianping Hu, David N Juurlink, J Michael Paterson, Laura E Targownik, Tanvir C Turin, Pierre Ernst, Samy Suissa, Colin R Dormuth, Brenda R Hemmelgarn, Gary F Teare, Patricia Caetano, Dan Chateau, David A Henry, J Michael Paterson, Jacques LeLorier, Adrian R Levy, Pierre Ernst, Robert W Platt, Ingrid S Sketris
Importance: The association between incretin-based drugs, such as dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) agonists, and acute pancreatitis is controversial. Objective: To determine whether the use of incretin-based drugs, compared with the use of 2 or more other oral antidiabetic drugs, is associated with an increased risk of acute pancreatitis. Design, Setting, and Participants: A large, international, multicenter, population-based cohort study was conducted using combined health records from 7 participating sites in Canada, the United States, and the United Kingdom...
October 1, 2016: JAMA Internal Medicine
Haris M Vaid, Ximena Camacho, John T Granton, Muhammad M Mamdani, Zhan Yao, Samantha Singh, David N Juurlink, Tara Gomes
Background. There are no Canadian prevalence studies on pulmonary arterial hypertension (PAH) to date. We described the characteristics of treated PAH patients and the healthcare utilization and costs associated with PAH in a population of public drug plan beneficiaries in Ontario, Canada. Methods. A retrospective cross-sectional analysis was conducted between April 2010 and March 2011 to identify treated PAH patients using population-based health administrative databases. We investigated demographic and clinical characteristics of treated PAH patients and conducted a cohort study to determine treatment patterns, healthcare utilization, and associated costs, over a one-year follow-up period (March 2012)...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Madhur Nayan, Antonio Finelli, Michael A S Jewett, David N Juurlink, Peter C Austin, Girish S Kulkarni, Robert J Hamilton
PURPOSE: Studies evaluating the association between statin use and survival outcomes in renal cell carcinoma have demonstrated conflicting results. Our objective was to evaluate this association in a large clinical cohort by using propensity score methods to reduce confounding from measured covariates. METHODS: We performed a retrospective review of 893 patients undergoing nephrectomy for unilateral, M0 renal cell carcinoma between 2000 and 2014 at a tertiary academic center...
July 14, 2016: Urologic Oncology
Madhur Nayan, Antonio Finelli, Michael A S Jewett, David N Juurlink, Peter C Austin, Girish S Kulkarni, Robert J Hamilton
BACKGROUND: Exposure to metformin, a medication used to treat diabetes, has been associated with improved survival outcomes in various malignancies. However, studies evaluating the association between metformin use and kidney cancer survival outcomes have demonstrated conflicting results. PATIENTS AND METHODS: We performed a retrospective review of diabetic patients undergoing nephrectomy for M0 renal cell carcinoma from 2000 to 2014 at a tertiary academic center...
June 23, 2016: Clinical Genitourinary Cancer
Paul D Foster, Ximena Camacho, Simone Vigod, Zhan Yao, David N Juurlink, J Michael Paterson, Muhammad M Mamdani, Diana Martins, Tara Gomes
BACKGROUND: Recently, several new atypical antipsychotic agents have been introduced in Ontario, and regulatory warnings have been issued regarding use of atypical antipsychotics in older adults. We sought to establish the impact of newer atypical antipsychotics on prescribing rates and costs. METHODS: We performed a population-based cross-sectional study of Ontario adults aged 65 years or more using atypical antipsychotics from Jan. 1, 2007, to Mar. 31, 2013. These people have universal access to publicly funded drugs through the Ontario Health Insurance Plan and the Ontario Drug Benefit...
April 2016: CMAJ Open
Angela den Dunnen, Leon Jacobse, Sandra Wiegman, Otto T Berg, Ludo B F Juurlink
We have studied the adsorption and desorption of O2 on Pd(100) by supersonic molecular beam techniques and thermal desorption spectroscopy. Adsorption measurements on the bare surface confirm that O2 initially dissociates for all kinetic energies between 56 and 380 meV and surface temperatures between 100 and 600 K via a direct mechanism. At and below 150 K, continued adsorption leads to a combined O/O2 overlayer. Dissociation of molecularly bound O2 during a subsequent temperature ramp leads to unexpected high atomic oxygen coverages, which are also obtained at high incident energy and high surface temperature...
June 28, 2016: Journal of Chemical Physics
Nikita Arora, Sandra Knowles, Tara Gomes, Muhammad M Mamdani, David N Juurlink, Corine Carlisle, Mina Tadrous
OBJECTIVE: Although antidepressants and antipsychotics are valuable medications in the treatment of select psychiatric disorders, there is increasing focus on the balance of risks and benefits of these drugs as prescribed, particularly in the pediatric population. We examined recent national trends and interprovincial variation in dispensing of antipsychotic and antidepressant prescriptions to the Canadian pediatric population. METHOD: We conducted a population-based cross-sectional study of antidepressant and antipsychotic prescriptions dispensed by Canadian pharmacies to the pediatric population (≤18 years) between 2010 and 2013...
May 12, 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Hillel M Finestone, David N Juurlink, Barry Power, Tara Gomes, Nicholas Pimlott
No abstract text is available yet for this article.
June 2016: Canadian Family Physician Médecin de Famille Canadien
Hillel M Finestone, David N Juurlink, Barry Power, Tara Gomes, Nicholas Pimlott
No abstract text is available yet for this article.
June 2016: Canadian Family Physician Médecin de Famille Canadien
Tara Gomes, Diana Martins, Mina Tadrous, J Michael Paterson, Baiju R Shah, David N Juurlink, Samantha Singh, Muhammad M Mamdani
OBJECTIVES: To evaluate the impact of new quantity limits for blood glucose test strips (BGTS) in August 2013 on utilization patterns and costs in the elderly population of Ontario, Canada. METHODS: We conducted a population-based, cross-sectional time series analysis of all individuals 65 years of age and older who received publically funded BGTSs between August 1, 2010, and July 31, 2015, in Ontario, Canada. The number of BGTSs dispensed and the associated costs were measured for 4 diabetes therapy subgroups-insulin, hypoglycemia-inducing oral agents, non-hypoglycemia-inducing oral agents, and no drug therapy-each month during the study period...
May 17, 2016: Canadian Journal of Diabetes
Yaron Finkelstein, Erin M Macdonald, Simon Hollands, Marco L A Sivilotti, Janine R Hutson, Muhammad M Mamdani, Gideon Koren, David N Juurlink
CONTEXT: Intentional overdose is a leading method of self-harm and suicide, and repeat attempts strongly predict eventual death by suicide. OBJECTIVES: To determine the risk of recurrence after a first intentional overdose. Secondary objectives included characterization of the temporal course and potential predictors of repeat overdose, a strong risk factor for death from suicide. METHODS: HASH(0x3b6d888) DESIGN: Population-based cohort study...
August 2016: Clinical Toxicology
Cansin Badan, Yasmine Heyrich, Marc T M Koper, Ludo B F Juurlink
We study the influence of substrate structure on desorption and crystallization of water deposited at 100 K on platinum. We use ultrathin water films adsorbed to well-defined but highly corrugated Pt(211) and Pt(221) surfaces. Desorption spectra reveal variations in the wetting and subsequent layers that critically depend on step type. Crystallization is induced at much lower substrate temperatures as compared to Pt(111). The crystalline ice (CI)-like layer is also significantly more stable on stepped surfaces as evidenced by a higher desorption energy...
May 5, 2016: Journal of Physical Chemistry Letters
Manuel J Kolb, Rachael G Farber, Jonathan Derouin, Cansin Badan, Federico Calle-Vallejo, Ludo B F Juurlink, Daniel R Killelea, Marc T M Koper
The interaction of platinum with water plays a key role in (electro)catalysis. Herein, we describe a combined theoretical and experimental study that resolves the preferred adsorption structure of water wetting the Pt(111)-step type with adjacent (111) terraces. Double stranded lines wet the step edge forming water tetragons with dissimilar hydrogen bonds within and between the lines. Our results qualitatively explain experimental observations of water desorption and impact our thinking of solvation at the Pt electrochemical interface...
April 1, 2016: Physical Review Letters
Tara Gomes, David N Juurlink
The dramatic rise in prescription opioid use in the past two decades across Canada and the United States has been accompanied by increased rates of adverse events, including premature death and neonatal abstinence syndrome. In Ontario, policies and programs designed to address inappropriate prescribing have been implemented with varying degrees of success. Emerging issues that require ongoing attention include the introduction of abuse-deterrent formulations of opioids and generic versions of long-acting oxycodone...
2016: Healthcare Quarterly
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