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https://www.readbyqxmd.com/read/29319477/publicly-funded-overactive-bladder-drug-treatment-patterns-in-ontario-over-15-years-an-ecologic-study
#1
Mina Tadrous, Dean Elterman, Wayne Khuu, Muhammad M Mamdani, David N Juurlink, Tara Gomes
INTRODUCTION: Medication is an important option for patients with overactive bladder (OAB), with four different drugs approved over the last 10 years including the first non-anticholinergic treatment, mirabegron. We set out to describe the number and rate of users of medication for the management of OAB over the last 15 years among residents of Ontario, Canada covered by the public drug programs. METHODS: We conducted a population-based, repeated cross-sectional study examining quarterly publically-funded prescription claims for OAB medications from January 2000 to June 2016 in Ontario, Canada...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29274228/prior-authorization-and-canadian-public-utilization-of-direct-acting-oral-anticoagulants
#2
Lulu Gao, Mina Tadrous, Sandra Knowles, Muhammad Mamdani, J Michael Paterson, David Juurlink, Tara Gomes
PURPOSE: Provincial public drug formularies in Canada have different mechanisms for reimbursement of direct-acting oral anticoagulants (DOACs). We investigate how these differences influence DOAC utilization and expenditure across the country. METHODS: We conducted a population-based, cross-sectional study of all out-patient prescriptions for OACs dispensed to public beneficiaries between January 1, 2010, and June 30, 2015. We calculated quarterly rates of OAC use and expenditures stratified by OAC type and province...
November 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/29261441/challenges-interpreting-chemoprevention-studies-using-observational-data
#3
Madhur Nayan, David N Juurlink, Antonio Finelli, Girish Kulkarni, Robert J Hamilton
No abstract text is available yet for this article.
December 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29226327/medication-use-and-kidney-cancer-survival-a-population-based-study
#4
Madhur Nayan, David N Juurlink, Peter C Austin, Erin M Macdonald, Antonio Finelli, Girish S Kulkarni, Robert J Hamilton
Several studies demonstrate that use of commonly-prescribed medications is associated with improved survival in various malignancies. Methods of classifying medication use in many of these studies, however, do not account for intermittent or cumulative use. Moreover, there are limited data in kidney cancer. Therefore, we performed a population-based cohort study utilizing healthcare databases in Ontario, Canada. We identified patients aged ≥65 with an incident diagnosis of kidney cancer between 1997-2013 and examined use of nine putative anti-neoplastic medications using prescription claims...
December 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29216018/impact-of-a-graduated-approach-on-opioid-initiation-and-loss-of-earnings-following-workplace-injury-a-time-series-analysis
#5
Tara Gomes, June Duesburry, Marc-Erick Theriault, Donna Bain, Samantha Singh, Diana Martins, David N Juurlink
OBJECTIVE: The aim of this study was to explore the impact of the Ontario Workplace Safety and Insurance Board's (WSIB's) graduated approach to opioid management on opioid prescribing and disability claim duration. METHODS: We studied patterns of opioid use and disability claim duration among Ontarians who received benefits through the WSIB between 2002 and 2013. We used interventional time series analysis to assess the impact of the WSIB graduated formulary on these trends...
December 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29117991/availability-of-naloxone-in-canadian-pharmacies-a-population-based-survey
#6
Alex M Cressman, Graham Mazereeuw, Qi Guan, Wenting Jia, Tara Gomes, David N Juurlink
BACKGROUND: Naloxone is life-saving when administered after opioid overdose. In March 2016, the Canadian government made the antidote available without prescription, but anecdotal reports suggest members of the public have difficulty in procuring it. We examined the availability of naloxone in community pharmacies across Canada. METHODS: We identified community pharmacies in Canada (n = 10 296) and randomly selected 506, stratified using proportionate allocation by population size...
November 8, 2017: CMAJ Open
https://www.readbyqxmd.com/read/29111110/impact-of-injectable-furosemide-hospital-shortage-on-congestive-heart-failure-outcomes-a-time-series-analysis
#7
MULTICENTER STUDY
Vivian S Tan, Danielle M Nash, Eric McArthur, Arsh K Jain, Amit X Garg, David N Juurlink, Matthew A Weir
BACKGROUND: Beginning in February 2012, there was a shortage of injectable furosemide in the province of Ontario, Canada. The objective of this study was to assess the effects of the furosemide shortage on heart failure outcomes in Ontario, Canada. METHODS: We determined which hospitals experienced a shortage of injectable furosemide using an online survey. We then used health administrative data to identify all patients who presented to those hospitals with congestive heart failure...
November 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28986124/real-world-health-care-utilization-and-effectiveness-of-omalizumab-for-the-treatment-of-severe-asthma
#8
Mina Tadrous, Wayne Khuu, Gerald Lebovic, Matthew B Stanbrook, Diana Martins, J Michael Paterson, Muhammad M Mamdani, David N Juurlink, Tara Gomes
BACKGROUND: Omalizumab is indicated for the treatment of moderate to severe asthma. There is limited observational evidence on the costs and effectiveness of omalizumab. OBJECTIVE: To examine the costs and effectiveness of omalizumab for treatment of severe asthma relative to nonusers. METHODS: We conducted a within-person repeated-measures matched cohort study in Ontario, Canada from April 1, 2012 to March 31, 2014. Continuous users of omalizumab were matched with up to 4 nonusers according to age, sex, recent specialist visits, oral corticosteroid use, asthma severity, and Charlson comorbidity score...
October 3, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28972983/gabapentin-opioids-and-the-risk-of-opioid-related-death-a-population-based-nested-case-control-study
#9
Tara Gomes, David N Juurlink, Tony Antoniou, Muhammad M Mamdani, J Michael Paterson, Wim van den Brink
BACKGROUND: Prescription opioid use is highly associated with risk of opioid-related death, with 1 of every 550 chronic opioid users dying within approximately 2.5 years of their first opioid prescription. Although gabapentin is widely perceived as safe, drug-induced respiratory depression has been described when gabapentin is used alone or in combination with other medications. Because gabapentin and opioids are both commonly prescribed for pain, the likelihood of co-prescription is high...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28970259/rethinking-doing-well-on-chronic-opioid-therapy
#10
REVIEW
David N Juurlink
No abstract text is available yet for this article.
October 2, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28919644/heterogeneous-catalytic-oxidation-of-simple-alcohols-by-transition-metals
#11
Leon Jacobse, Sebastiaan O Vink, Sven Wijngaarden, Ludo B F Juurlink
The "exploding" flask demonstration presents a well-known illustration of heterogeneous catalyzed methanol oxidation. We find that for the same vapor pressure, the demonstration also works for all primary and secondary alcohols up to butanol but not for a tertiary alcohol. Also, we show that the demonstration works for a large range of transition metal catalysts. Hence, this demonstration, which is often applied for the repetitive explosions when methanol is used, may also be used to argue the requirement of initial dehydrogenation of the alcohol to an aldehyde in the catalytic reaction mechanism to support the general insensitivity to reactant molecules in heterogeneous catalysis in contrast to biological catalysis and to provide proof for activity trends as often depicted by volcano plots...
September 12, 2017: Journal of Chemical Education
https://www.readbyqxmd.com/read/28919643/misconceptions-in-the-exploding-flask-demonstration-resolved-through-students-critical-thinking
#12
Rick Spierenburg, Leon Jacobse, Iris de Bruin, Daan J van den Bos, Dominique M Vis, Ludo B F Juurlink
As it connects to a large set of important fundamental ideas in chemistry and analytical techniques discussed in high school chemistry curricula, we review the exploding flask demonstration. In this demonstration, methanol vapor is catalytically oxidized by a Pt wire catalyst in an open container. The exothermicity of reactions occurring at the catalytic surface heats the metal to the extent that it glows. When restricting reactant and product gas flow, conditions may favor repetitive occurrence of a small explosion...
September 12, 2017: Journal of Chemical Education
https://www.readbyqxmd.com/read/28867560/prevalence-and-characteristics-of-opioid-related-deaths-involving-alcohol-in-ontario-canada
#13
Tara Gomes, David N Juurlink, Muhammad M Mamdani, J Michael Paterson, Wim van den Brink
BACKGROUND: While it is well known that patients receiving opioids should refrain from alcohol consumption, little is known about the involvement of alcohol in opioid-related deaths. METHODS: We conducted a population-based analysis of opioid-related deaths in Ontario with and without alcohol involvement between 1993 and 2013, and reported rates overall and stratified by manner of death. We compared the characteristics of individuals who died of an opioid overdose based on the presence or absence of alcohol involvement...
August 5, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28750272/medication-use-and-kidney-cancer-risk-a%C3%A2-population-based-study
#14
Madhur Nayan, David N Juurlink, Peter C Austin, Erin M Macdonald, Antonio Finelli, Girish S Kulkarni, Robert J Hamilton
BACKGROUND: Exposure to commonly prescribed medications may be associated with cancer risk. However, there is limited data in kidney cancer. Furthermore, methods of classifying cumulative medication exposure in previous studies may be prone to bias. METHODS: We conducted a population-based case-control study of 10,377 incident kidney cancer cases aged ≥66 years matched with 35,939 controls on age, sex, history of hypertension, comorbidity score, and geographic location...
September 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28652873/the-value-of-complementing-administrative-data-with-abstracted-information-on-smoking-and-obesity-a-study-in-kidney-cancer
#15
Madhur Nayan, Robert J Hamilton, Antonio Finelli, Peter C Austin, Girish S Kulkarni, David N Juurlink
INTRODUCTION: Variables, such as smoking and obesity, are rarely available in administrative databases. We explored the added value of including these data in an administrative database study evaluating the association of statin use with survival in kidney cancer. METHODS: We linked administrative data with chart-abstracted data on smoking and obesity for 808 patients undergoing nephrectomy for kidney cancer. Base models consisted of variables from administrative databases (age, sex, year of surgery, and different measures of comorbidity [to compare their sensitivity to smoking and obesity data]); extended models added chart-abstracted data...
June 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28620909/pregabalin-and-heart-failure-a-population-based-study
#16
Joanne M-W Ho, Erin M Macdonald, Jin Luo, Tara Gomes, Tony Antoniou, Muhammad M Mamdani, David N Juurlink
PURPOSE: The anticonvulsant pregabalin is increasingly prescribed for pain, seizures, and psychiatric disorders. Although evidence suggests pregabalin can cause edema and heart failure, its cardiac safety profile in clinical practice is unknown. We sought to examine the risk of heart failure among older patients receiving pregabalin compared to those receiving gabapentin. METHODS: We conducted a population-based cohort study of Ontarians aged 66 and older with a history of seizure who received pregabalin or gabapentin between April 2013 and March 2014...
September 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28620871/lipophilic-statins-and-the-risk-of-intracranial-hemorrhage-following-ischemic-stroke-a-population-based-study
#17
Kieran L Quinn, Erin M Macdonald, Muhammad M Mamdani, Christina Diong, David N Juurlink
BACKGROUND: Statins are commonly prescribed for the secondary prevention of ischemic stroke, but there is conflicting evidence as to whether they increase the risk of intracranial hemorrhage. Lipophilic statins cross the blood-brain barrier more freely than hydrophilic statins and may therefore increase the risk of intracranial hemorrhage. OBJECTIVE: To determine whether, in older patients following ischemic stroke, receipt of lipophilic statins was associated with differences in the risk of intracranial hemorrhage...
October 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28608364/critical-appraisal-of-the-application-of-propensity-score-methods-in-the-urology-literature
#18
Madhur Nayan, Robert J Hamilton, David N Juurlink, Antonio Finelli, Girish S Kulkarni, Peter C Austin
OBJECTIVES: To determine whether studies that used propensity score (PS) methods in the urology literature provide sufficient detail to allow scientific reproducibility and whether appropriate statistical tests were used to obtain valid measures of effect. MATERIALS AND METHODS: We searched OVID Medline and the Science Citation Index from inception to November 2016 to identify studies that used PS methods in five general urology journals. From each included article, we extracted pertinent information related to the PS methodology, such as estimation of the PS, whether balance diagnostics were performed, and the statistical analysis performed...
June 13, 2017: BJU International
https://www.readbyqxmd.com/read/28606977/loperamide-abuse
#19
Tony Antoniou, David N Juurlink
No abstract text is available yet for this article.
June 12, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28564561/a-1980-letter-on-the-risk-of-opioid-addiction
#20
LETTER
Pamela T M Leung, Erin M Macdonald, Matthew B Stanbrook, Irfan A Dhalla, David N Juurlink
To the Editor: The prescribing of strong opioids such as oxycodone has increased dramatically in the United States and Canada over the past two decades. From 1999 through 2015, more than 183,000 deaths from prescription opioids were reported in the United States, and millions of Americans are now..
June 1, 2017: New England Journal of Medicine
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