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https://www.readbyqxmd.com/read/28926400/hepatitis-b-hepatitis-c-and-mortality-among-hiv-positive-individuals
#1
Alicia C Thornton, Sophie Jose, Sanjay Bhagani, David Chadwick, David Dunn, Richard Gilson, Janice Main, Mark Nelson, Alison Rodger, Chris Taylor, Elaney Youssef, Clifford Leen, Mark Gompels, Stephen Kegg, Achim Schwenk, Caroline Sabin
OBJECTIVES: To compare rates of all-cause, liver-related and AIDS-related mortality among individuals who are HIV mono-infected with those co-infected with HIV and hepatitis B (HBV) and/or hepatitis C (HCV) viruses. DESIGN: An ongoing observational cohort study collating routinely collected clinical data on HIV-positive individuals attending for care at HIV treatment centres throughout the UK. METHODS: Individuals were included if they had been seen for care from 2004 onwards and had tested for HBV and HCV...
September 18, 2017: AIDS
https://www.readbyqxmd.com/read/28924832/influence-of-linkage-stereochemistry-and-protecting-groups-on-glycosidic-bond-stability-of-sodium-cationized-glycosyl-phosphates
#2
Y Zhu, Zhihua Yang, M T Rodgers
Energy-resolved collision-induced dissociation (ER-CID) experiments of sodium cationized glycosyl phosphate complexes, [GP x +Na](+), are performed to elucidate the effects of linkage stereochemistry (α versus β), the geometry of the leaving groups (1,2-cis versus 1,2-trans), and protecting groups (cyclic versus non-cyclic) on the stability of the glycosyl phosphate linkage via survival yield analyses. A four parameter logistic dynamic fitting model is used to determine CID50% values, which correspond to the level of rf excitation required to produce 50% dissociation of the precursor ion complexes...
September 18, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28924206/ephrin-a2-regulates-excitatory-neuron-differentiation-and-interneuron-migration-in-the-developing-neocortex
#3
Jihane Homman-Ludiye, William C Kwan, Mitchell J de Souza, Jennifer Rodger, James A Bourne
The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult ephrin-A2 knockout mice we consistently observed focal patches of disorganized neocortical laminar architecture, ranging in severity from reduced neuronal density to a complete lack of neurons. Loss of ephrin-A2 in the pre-optic area of the diencephalon reduced the migration of neocortex-bound interneurons from this region...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28918877/raltegravir-1200-mg-once-daily-versus-raltegravir-400-mg-twice-daily-with-tenofovir-disoproxil-fumarate-and-emtricitabine-for-previously-untreated-hiv-1-infection-a-randomised-double-blind-parallel-group-phase-3-non-inferiority-trial
#4
Pedro Cahn, Richard Kaplan, Paul E Sax, Kathleen Squires, Jean-Michel Molina, Anchalee Avihingsanon, Winai Ratanasuwan, Evelyn Rojas, Mohammed Rassool, Mark Bloch, Linos Vandekerckhove, Peter Ruane, Yazdan Yazdanpanah, Christine Katlama, Xia Xu, Anthony Rodgers, Lilly East, Larissa Wenning, Sandy Rawlins, Brenda Homony, Peter Sklar, Bach-Yen Nguyen, Randi Leavitt, Hedy Teppler
BACKGROUND: Once daily regimens are preferred for HIV-1 treatment, to facilitate adherence and improve quality of life. We compared a new once daily formulation of raltegravir to the currently marketed twice daily formulation. METHODS: In this randomised, double-blind, parallel-group, phase 3, non-inferiority study, we enrolled participants aged 18 years or older with HIV-1 RNA of 1000 or more copies per mL and no previous antiretroviral treatment at 139 sites worldwide...
September 11, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28918443/brief-report-personality-mediates-the-relationship-between-autism-quotient-and-well-being-a-conceptual-replication-using-self-report
#5
Jonathan D Rodgers, Jennifer Lodi-Smith, Patrick L Hill, Seth M Spain, Christopher Lopata, Marcus L Thomeer
Autism spectrum disorder (ASD) impacts well-being across the lifespan. Individuals with ASD evidence differences in personality traits and self-concept clarity that are predictors of well-being in typically-developing individuals. The current research replicates a growing body of evidence demonstrating differences in well-being and personality between individuals low in ASD characteristics (n = 207) and individuals high in ASD characteristics (n = 46) collected from the general population using an online survey...
September 16, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28918202/implementation-of-a-risk-stratified-opioid-weaning-protocol-in-a-pediatric-intensive-care-unit
#6
L Nelson Sanchez-Pinto, Lara P Nelson, Phuong Lieu, Joyce Y Koh, John W Rodgers, Krichelle A Larson, Jennifer M Huson, Rambod Amirnovin
PURPOSE: Opioids are important in the care of critically ill children. However, their use is associated with complications including delirium, dependence, withdrawal, and bowel dysfunction. Our aim was to implement a risk-stratified opioid weaning protocol to reduce the duration of opioids without increasing the incidence of withdrawal. METHODS: A pre- and post-interventional prospective study was undertaken in a large children's hospital pediatric ICU where we implemented a risk-stratified opioid weaning protocol...
September 7, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28916704/delayed-neutrophil-apoptosis-enhances-net-formation-in-cystic-fibrosis
#7
Robert D Gray, Gareth Hardisty, Kate H Regan, Maeve Smith, Calum T Robb, Rodger Duffin, Annie Mackellar, Jennifer M Felton, Lily Paemka, Brian N McCullagh, Christopher D Lucas, David A Dorward, Edward F McKone, Gordon Cooke, Seamas C Donnelly, Pradeep K Singh, David A Stoltz, Christopher Haslett, Paul B McCray, Moira K B Whyte, Adriano G Rossi, Donald J Davidson
BACKGROUND: Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is described in CF although it is unclear whether this is a primary neutrophil defect or a response to chronic inflammation. Increased levels of neutrophil extracellular traps (NETs) have been measured in CF and we aimed to investigate the causal relationship between these phenomena and their potential to serve as a driver of inflammation...
September 15, 2017: Thorax
https://www.readbyqxmd.com/read/28912260/decoupling-between-diastolic-pulmonary-artery-pressure-and-pulmonary-capillary-wedge-pressure-as-a-prognostic-factor-after-continuous-flow-ventricular-assist-device-implantation
#8
Teruhiko Imamura, Ben Chung, Ann Nguyen, Daniel Rodgers, Gabriel Sayer, Sirtaz Adatya, Nitasha Sarswat, Gene Kim, Jayant Raikhelkar, Takeyohi Ota, Tae Song, Colleen Juricek, Viktoriya Kagan, Valluvan Jeevanandam, Mandeep Mehra, Daniel Burkhoff, Nir Uriel
BACKGROUND: A cohort of heart failure (HF) patients receiving left ventricular assist devices (LVADs) has decoupling of their diastolic pulmonary artery pressure and pulmonary capillary wedge pressure. However, the clinical implications of this decoupling remain unclear. METHODS AND RESULTS: In this prospective study, patients with LVADs underwent routine invasive hemodynamic ramp testing with right heart catheterization, during which LVAD speeds were adjusted. Inappropriate decoupling was defined as a >5 mm Hg difference between diastolic pulmonary artery pressure and pulmonary capillary wedge pressure...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28910672/brief-report-a-network-analysis-of-self-cutting-risk-among-late-adolescent-girls-exposed-to-dating-violence
#9
Daniel Ian Gittins Stone, Russell DuBois, Brett DeJesus, Rachel F Rodgers, Christie Rizzo
Adolescent self-directed violence (SDV) is a major public health concern. Adolescent girls exposed to dating violence (DV) are a particularly vulnerable group. Numerous studies have examined the number and type of SDV risk factors, but few examined global patterns of relationships among them. Exploring global patterns of risk is crucial to developing targeted prevention efforts. In this study we applied a network model to identify risk patterns for a common form of SDV, self-cutting, among American adolescent girls (N = 109) with history of DV...
September 11, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28904078/towards-a-systems-approach-to-human-cytochrome-p450-ensemble-interactions-between-cyp2d6-and-cyp2e1-and-their-functional-consequences
#10
Dmitri R Davydov, Nadezhda Y Davydova, John T Rodgers, Thomas H Rushmore, Jeffrey P Jones
Functional cross-talk among human drug-metabolizing cytochromes P450 through their association is a topic of emerging importance. Here we studied the interactions of human CYP2D6, a major metabolizer of psychoactive drugs, with one of the most prevalent human P450 enzymes, ethanol-inducible CYP2E1. Detection of P450-P450 interactions was accomplished through luminescence resonance energy transfer (LRET) between labeled proteins incorporated into human liver microsomes and the microsomes of insect cells containing NADPH-cytochrome P450 reductase...
September 13, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28901568/shared-decision-making-in-the-paediatric-field-a-literature-review-and-concept-analysis
#11
REVIEW
Eun Sook Park, In Young Cho
AIM: The concept of shared decision-making is poorly defined and often used interchangeably with related terms. The aim of this study was to delineate and clarify the concept of shared decision-making in the paediatric field. METHOD: Rodgers and Knafl's evolutionary concept analysis was used to delineate and clarify the concept. Following a search of the CINAHL, PubMed and MEDLINE databases and online journals between 1995 and 2016, we included a total of 42 articles that referred to shared decision-making in the paediatric field...
September 13, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28895083/influence-of-transition-metal-cationization-versus-sodium-cationization-and-protonation-on-the-gas-phase-tautomeric-conformations-and-stability-of-uracil-application-to-ura-cu-and-ura-ag
#12
T E Akinyemi, R R Wu, Y-W Nei, N A Cunningham, H A Roy, J D Steill, G Berden, J Oomens, M T Rodgers
The gas-phase conformations of transition metal cation-uracil complexes, [Ura+Cu](+) and [Ura+Ag](+), were examined via infrared multiple photon dissociation (IRMPD) action spectroscopy and theoretical calculations. IRMPD action spectra were measured over the IR fingerprint and hydrogen-stretching regions. Structures and linear IR spectra of the stable tautomeric conformations of these complexes were initially determined at the B3LYP/6-31G(d) level. The four most stable structures computed were also examined at the B3LYP/def2-TZVPPD level to improve the accuracy of the predicted IR spectra...
September 11, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28891688/double-decomposition-of-level-1-variables-in-multilevel-models-an-analysis-of-the-flynn-effect-in-the-nsly-data
#13
Patrick O'Keefe, Joseph Lee Rodgers
This paper introduces an extension of cluster mean centering (also called group mean centering) for multilevel models, which we call "double decomposition (DD)." This centering method separates between-level variance, as in cluster mean centering, but also decomposes within-level variance of the same variable. This process retains the benefits of cluster mean centering but allows for context variables derived from lower level variables, other than the cluster mean, to be incorporated into the model. A brief simulation study is presented, demonstrating the potential advantage (or even necessity) for DD in certain circumstances...
September 11, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28890189/human-papillomavirus-vaccination-coverage-using-two-dose-or-three-dose-schedule-criteria
#14
Xia Lin, Loren Rodgers, Liping Zhu, Shannon Stokley, Elissa Meites, Lauri E Markowitz
In October 2016, the Advisory Committee on Immunization Practices (ACIP) updated the human papillomavirus (HPV) vaccination recommendation to include a 2-dose schedule for U.S. adolescents initiating the vaccine series before their 15th birthday. We analyzed records for >4million persons aged 9-17years receiving any HPV vaccine by the end of each quarter during January 1, 2014-September 30, 2016 from six Immunization Information Systems Sentinel Sites, and reclassified HPV vaccination up-to-date coverage according to the updated recommendations...
September 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28887490/organic-silica-interactions-in-saline-elucidating-the-structural-influence-of-calcium-in-low-salinity-enhanced-oil-recovery
#15
J L Desmond, K Juhl, T Hassenkam, S L S Stipp, T R Walsh, P M Rodger
Enhanced oil recovery using low-salinity solutions to sweep sandstone reservoirs is a widely-practiced strategy. The mechanisms governing this remain unresolved. Here, we elucidate the role of Ca(2+) by combining chemical force microscopy (CFM) and molecular dynamics (MD) simulations. We probe the influence of electrolyte composition and concentration on the adsorption of a representative molecule, positively-charged alkylammonium, at the aqueous electrolyte/silica interface, for four electrolytes: NaCl, KCl, MgCl2, and CaCl2...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28880927/scf-kit-signaling-induces-endothelin-3-synthesis-and-secretion-thereby-activates-and-regulates-endothelin-b-receptor-for-generating-temporally-and-spatially-precise-nitric-oxide-to-modulate-scf-and-or-kit-expressing-cell-functions
#16
Lei L Chen, Jing Zhu, Jonathan Schumacher, Chongjuan Wei, Latha Ramdas, Victor G Prieto, Arnie Jimenez, Marco A Velasco, Sheryl R Tripp, Robert H I Andtbacka, Launce Gouw, George M Rodgers, Liansheng Zhang, Benjamin K Chan, Pamela B Cassidy, Robert S Benjamin, Sancy A Leachman, Marsha L Frazier
We demonstrate that SCF-KIT signaling induces synthesis and secretion of endothelin-3 (ET3) in human umbilical vein endothelial cells and melanoma cells in vitro, gastrointestinal stromal tumors, human sun-exposed skin, and myenteric plexus of human colon post-fasting in vivo. This is the first report of a physiological mechanism of ET3 induction. Integrating our finding with supporting data from literature leads us to discover a previously unreported pathway of nitric oxide (NO) generation derived from physiological endothelial NO synthase (eNOS) or neuronal NOS (nNOS) activation (referred to as the KIT-ET3-NO pathway)...
2017: PloS One
https://www.readbyqxmd.com/read/28876964/flourishing-an-evolutionary-concept-analysis
#17
Christine Agenor, Norma Conner, Karen Aroian
PURPOSE: Mental health is an important measure of public health (WHO, 2004); however, nursing practice and research continues to prioritize mental illness, rather than well-being (Wand, 2011). Flourishing is a recent concept in the field of well-being. The term has been used sparingly in nursing practice and research, and conceptual clarification is needed to promote comprehensive understanding of the phenomenon. The purpose of this study is to critically analyze flourishing, assess the maturity of the concept, and provide recommendations for future research, education, and practice...
September 6, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28874584/a-classical-view-on-nonclassical-nucleation
#18
Paul J M Smeets, Aaron R Finney, Wouter J E M Habraken, Fabio Nudelman, Heiner Friedrich, Jozua Laven, James J De Yoreo, P Mark Rodger, Nico A J M Sommerdijk
Understanding and controlling nucleation is important for many crystallization applications. Calcium carbonate (CaCO3) is often used as a model system to investigate nucleation mechanisms. Despite its great importance in geology, biology, and many industrial applications, CaCO3 nucleation is still a topic of intense discussion, with new pathways for its growth from ions in solution proposed in recent years. These new pathways include the so-called nonclassical nucleation mechanism via the assembly of thermodynamically stable prenucleation clusters, as well as the formation of a dense liquid precursor phase via liquid-liquid phase separation...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28874432/stopping-anticoagulation-in-a-woman-with-unprovoked-venous-thromboembolism
#19
Faizan Khan, Grégoire Le Gal, Marc A Rodger
No abstract text is available yet for this article.
September 5, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28871218/mapping-sonification-for-perception-and-action-in-motor-skill-learning
#20
John F Dyer, Paul Stapleton, Matthew Rodger
No abstract text is available yet for this article.
2017: Frontiers in Neuroscience
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