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Suzanne Oparil, Maria Czarina Acelajado, George L Bakris, Dan R Berlowitz, Renata Cífková, Anna F Dominiczak, Guido Grassi, Jens Jordan, Neil R Poulter, Anthony Rodgers, Paul K Whelton
Systemic arterial hypertension is the most important modifiable risk factor for all-cause morbidity and mortality worldwide and is associated with an increased risk of cardiovascular disease (CVD). Fewer than half of those with hypertension are aware of their condition, and many others are aware but not treated or inadequately treated, although successful treatment of hypertension reduces the global burden of disease and mortality. The aetiology of hypertension involves the complex interplay of environmental and pathophysiological factors that affect multiple systems, as well as genetic predisposition...
March 22, 2018: Nature Reviews. Disease Primers
Julia Nemiroff, David Sarraf, Juan Pablo Davila, Damien Rodger
PURPOSE: To present the multimodal retinal imaging findings, including optical coherence tomography (OCT) angiography, of an atypical case of acute macular neuroretinopathy (AMN). METHODS: The multimodal retinal imaging findings, including structural OCT and OCT angiography, of an atypical case of AMN are presented. RESULTS: A 23-year old woman, with a history of an unrelenting sinusitis treated with prednisone therapy and decongestants, presented with an acute scotoma of the right eye...
March 20, 2018: Retinal Cases & Brief Reports
Kunal N Karmali, Donald M Lloyd-Jones, Joep van der Leeuw, David C Goff, Salim Yusuf, Alberto Zanchetti, Paul Glasziou, Rodney Jackson, Mark Woodward, Anthony Rodgers, Bruce C Neal, Eivind Berge, Koon Teo, Barry R Davis, John Chalmers, Carl Pepine, Kazem Rahimi, Johan Sundström
BACKGROUND: Clinical practice guidelines have traditionally recommended blood pressure treatment based primarily on blood pressure thresholds. In contrast, using predicted cardiovascular risk has been advocated as a more effective strategy to guide treatment decisions for cardiovascular disease (CVD) prevention. We aimed to compare outcomes from a blood pressure-lowering treatment strategy based on predicted cardiovascular risk with one based on systolic blood pressure (SBP) level. METHODS AND FINDINGS: We used individual participant data from the Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC) from 1995 to 2013...
March 2018: PLoS Medicine
Catherine Delves-Yates, Andrea Stockl, Jenny Moore
BACKGROUND: Concept analysis is frequently the first step novice nurse researchers take when beginning their work. However, the value of concept analysis in generating theory is debated, and although there are many models researchers can use, few provide guidance for applying them or overviews of their philosophical underpinnings. AIM: To share learning about challenges encountered when undertaking concept analysis and to present an adaptation of Rodgers ( 1989 ) model created to overcome these...
March 16, 2018: Nurse Researcher
Verònica Gálvez, Adrienne Li, Christina Huggins, Paul Glue, Donel Martin, Andrew A Somogyi, Angelo Alonzo, Anthony Rodgers, Philip B Mitchell, Colleen K Loo
BACKGROUND: Ketamine research in depression has mostly used intravenous, weight-based approaches, which are difficult to translate clinically. Intranasal (IN) ketamine is a promising alternative but no controlled data has been published on the feasibility, safety and potential efficacy of repeated IN ketamine treatments. METHODS: This randomised, double-blind, placebo-controlled pilot study compared a 4-week course of eight treatments of 100 mg ketamine or 4.5 mg midazolam...
March 1, 2018: Journal of Psychopharmacology
Catriona Crossan, Hakim-Moulay Dehbi, Hilarie Williams, Neil Poulter, Anthony Rodgers, Stephen Jan, Simon Thom, Joanne Lord
INTRODUCTION: The 'Use of a Multi-drug Pill in Reducing cardiovascular Events' (UMPIRE) trial was a randomised controlled clinical trial evaluating the impact of a polypill strategy on adherence to indicated medication in a population with established cardiovascular disease (CVD) of or at high risk thereof. The aim of Researching the UMPIRE Processes for Economic Evaluation in the National Health Service (RUPEE NHS) is to estimate the potential health economic impact of a polypill strategy for CVD prevention within the NHS using UMPIRE trial and other relevant data...
March 14, 2018: BMJ Open
David M Tehrani, Daniel Rodgers, Sirtaz Adatya, Nitasha Sarswat, Jayant Raikhelkar, Gene H Kim, Gabriel Sayer, Nir Uriel
We aim to evaluate the echocardiographic/hemodynamic effects of left ventricular assist devices in African American (AA) versus non-AA patients undergoing ramp speed optimization and its subsequent effect on readmissions. In 65 patients (26 AA), no differences in baseline echocardiographic/hemodynamic parameters were noted. During ramp testing, there was a significantly greater increase in cardiac output (slope: 0.29 ± 0.24 vs. 0.15 ± 0.12, p < 0.01) with more rapid decrease in left ventricular end-diastolic diameter (slope: -0...
March 13, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Ebony Rempel, Lorie Donelle, Jodi Hall, Susan Rodger
Violence against women (VAW) is a global social issue affecting health, social, and legal systems. VAW contributes to the inequities with respect to the social determinants of health that many women face today. The onus on self-care in the face of violence remains almost singularly with the victims. Access to information and services in support of women's health and safety is fundamental. However, research gaps exist regarding how women access health information across all stages of an abusive intimate relationship...
March 14, 2018: Informatics for Health & Social Care
Kate Rocklein-Kemplin, Olimpia Paun, Noel Sons, Jonathan W Brandon
Despite many resilience studies and resilience-building initiatives in the military, resilience as a concept remains granularly unexamined, vague, and inconsistently interpreted throughout military-specific research literature. Specifically, studies of military suicide and related mental health constructs assert that Servicemembers in Special Operations Forces (SOF) possess higher levels of resilience without providing an empirical basis for these statements. To provide rigorous evidence for future studies of resilience in SOF, a concept analysis was performed via Rodgers' evolutionary method to contextualize resilience in the SOF community and provide accurate redefinitions on which theoretical and methodological frameworks can be constructed reliably...
2018: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Yu Shi, Danqing Hu, Erin L Rodgers, Slavica K Katusic, Stephen J Gleich, Andrew C Hanson, Darrell R Schroeder, Randall P Flick, David O Warner
BACKGROUND: Utilization of general anesthesia in children has important policy, economic, and healthcare delivery implications, yet there is little information regarding the epidemiology of these procedures in the United States. AIMS: The primary objective of this study was to describe in a geographically defined population the incidence of procedures requiring general anesthesia up to the child's third birthday, and the patient characteristics associated with receiving these procedures...
March 13, 2018: Paediatric Anaesthesia
Joseph C Dysthe, Torrey Rodgers, Thomas W Franklin, Kellie J Carim, Michael K Young, Kevin S McKelvey, Karen E Mock, Michael K Schwartz
Information on the distribution of multiple species in a common landscape is fundamental to effective conservation and management. However, distribution data are expensive to obtain and often limited to high-profile species in a system. A recently developed technique, environmental DNA (eDNA) sampling, has been shown to be more sensitive than traditional detection methods for many aquatic species. A second and perhaps underappreciated benefit of eDNA sampling is that a sample originally collected to determine the presence of one species can be re-analyzed to detect additional taxa without additional field effort...
March 2018: Ecology and Evolution
Ryan R Witt, John J Rodger, John C Rodger
Lucrin Depot (AbbVie), a 1-month microsphere gonadotrophin-releasing hormone (GnRH) agonist preparation, was investigated as a potential agent to synchronise cycling in the fat-tailed dunnart (Sminthopsis crassicaudata). Forty-eight randomly selected females were treated with 5 or 10mgkg-1 Lucrin Depot (n=24 per dose). Eighteen females per treatment had their reproductive activity scored at 4, 8, 12 and 16 weeks using two ovarian (Graafian follicle and corpus luteum status) and two reproductive tract (uterine and vaginal muscularity and vascularity) parameters that formed a reproductive activity score...
March 2018: Reproduction, Fertility, and Development
Kathleen M Scott, John Williams, Cody M B Porter, Sydney Russel, Tara L Harmer, John H Paul, Kirsten M Antonen, Megan K Bridges, Gary J Camper, Christie K Campla, Leila G Casella, Eva Chase, James W Conrad, Mercedez C Cruz, Darren S Dunlap, Laura Duran, Elizabeth M Fahsbender, Dawn B Goldsmith, Ryan F Keeley, Matthew R Kondoff, Breanna I Kussy, Marannda K Lane, Stephanie Lawler, Brittany A Leigh, Courtney Lewis, Lygia M Lostal, Devon Marking, Paola A Mancera, Evan C McClenthan, Emily A McIntyre, Jessica A Mine, Swapnil Modi, Brittney D Moore, William A Morgan, Kaleigh M Nelson, Kimmy N Nguyen, Nicholas Ogburn, David G Parrino, Anangamanjari D Pedapudi, Rebecca P Pelham, Amanda M Preece, Elizabeth A Rampersad, Jason C Richardson, Christina M Rodgers, Brent L Schaffer, Nancy E Sheridan, Michael R Solone, Zachery R Staley, Maki Tabuchi, Ramond J Waide, Pauline W Wanjugi, Suzanne Young, Alicia Clum, Chris Daum, Marcel Huntemann, Natalia Ivanova, Nikos Kyrpides, Natalia Mikhailova, Krishnaveni Palaniappan, Manoj Pillay, T B K Reddy, Nicole Shapiro, Dimitrios Stamatis, Neha Varghese, Tanja Woyke, Rich Boden, Sharyn K Freyermuth, Cheryl A Kerfeld
Chemolithoautotrophic bacteria from the genera Hydrogenovibrio, Thiomicrorhabdus, and Thiomicrospira are common, sometimes dominant, isolates from sulfidic habitats including hydrothermal vents, soda and salt lakes, and marine sediments. Their genome sequences confirm their membership in a deeply branching clade of the Gammaproteobacteria. Several adaptations to heterogeneous habitats are apparent. Their genomes include large numbers of genes for sensing and responding to their environment (EAL- and GGDEF-domain proteins, and methyl-accepting chemotaxis proteins) despite their small sizes (2...
March 9, 2018: Environmental Microbiology
Rosa Chan, Tom De Bruyn, Matthew Wright, Fabio Broccatelli
PURPOSE: Volume of distribution at steady state (Vdss ) is a fundamental pharmacokinetic (PK) parameter driven predominantly by passive processes and physicochemical properties of the compound. Human Vdss can be estimated using in silico mechanistic methods or empirically scaled from Vdss values obtained from preclinical species. In this study the accuracy and the complementarity of these two approaches are analyzed leveraging a large data set (over 150 marketed drugs). METHODS: For all the drugs analyzed in this study experimental in vitro measurements of LogP, plasma protein binding and pKa are used as input for the mechanistic in silico model to predict human Vdss ...
March 8, 2018: Pharmaceutical Research
Rachel Margaret Coyle, Ada Rose Miltz, Fiona C Lampe, Janey Sewell, Andrew N Phillips, Andrew Speakman, Jyoti Dhar, Lorraine Sherr, S Tariq Sadiq, Stephen Taylor, Daniel R Ivens, Simon Collins, Jonathan Elford, Jane Anderson, Alison Rodger
OBJECTIVES: In the UK, people of black ethnicity experience a disproportionate burden of HIV and STI. We aimed to assess the association of ethnicity with sexual behaviour and sexual health among women and heterosexual men attending genitourinary medicine (GUM) clinics in England. METHODS: The Attitudes to and Understanding of Risk of Acquisition of HIV is a cross-sectional, self-administered questionnaire study of HIV negative people recruited from 20 GUM clinics in England, 2013-2014...
March 8, 2018: Sexually Transmitted Infections
Saras Henderson, Maria Horne, Ruth Hills, Elizabeth Kendall
This study aims to conduct a concept analysis on cultural competence in community healthcare. Clarification of the concept of cultural competence is needed to enable clarity in the definition and operation, research and theory development to assist healthcare providers to better understand this evolving concept. Rodgers' evolutionary concept analysis method was used to clarify the concept's context, surrogate terms, antecedents, attributes and consequences and to determine implications for further research...
March 7, 2018: Health & Social Care in the Community
Alexander D Tang, William Bennett, Claire Hadrill, Jessica Collins, Barbora Fulopova, Karen Wills, Aidan Bindoff, Rohan Puri, Michael I Garry, Mark R Hinder, Jeffery J Summers, Jennifer Rodger, Alison J Canty
Repetitive transcranial magnetic stimulation (rTMS) is commonly used to modulate cortical plasticity in clinical and non-clinical populations. Clinically, rTMS is delivered to targeted regions of the cortex at high intensities (>1 T). We have previously shown that even at low intensities, rTMS induces structural and molecular plasticity in the rodent cortex. To determine whether low intensity rTMS (LI-rTMS) alters behavioural performance, daily intermittent theta burst LI-rTMS (120 mT) or sham was delivered as a priming or consolidating stimulus to mice completing 10 consecutive days of skilled reaching training...
March 5, 2018: Scientific Reports
Fiona J Rowe, Kerry Hanna, Jennifer R Evans, Carmel P Noonan, Marta Garcia-Finana, Caroline S Dodridge, Claire Howard, Kathryn A Jarvis, Sonia L MacDiarmid, Tallat Maan, Lorraine North, Helen Rodgers
BACKGROUND: Acquired brain injury can cause eye movement disorders which may include: strabismus, gaze deficits and nystagmus, causing visual symptoms of double, blurred or 'juddery' vision and reading difficulties. A wide range of interventions exist that have potential to alleviate or ameliorate these symptoms. There is a need to evaluate the effectiveness of these interventions and the timing of their implementation. OBJECTIVES: We aimed to assess the effectiveness of any intervention and determine the effect of timing of intervention in the treatment of strabismus, gaze deficits and nystagmus due to acquired brain injury...
March 5, 2018: Cochrane Database of Systematic Reviews
Katherine C Rodgers, Alexandria E Arnold, Daniel K Newhard, Kelsey Cline, Randolph L Winter
No abstract text is available yet for this article.
March 15, 2018: Journal of the American Veterinary Medical Association
Esther Lee Kim, Damien C Rodger, Narsing A Rao
Purpose: While there are many known etiologies of choroidal neovascularization (CNV), tuberculosis is not a well-known causative agent. In this case series, we highlight CNV occurring secondary to tuberculous chorioretinitis, its presentation, and its management. Observations: We retrospectively reviewed the charts and imaging of four patients who presented with presumed tuberculous chorioretinitis and CNV. Three of these patients had signs of intraocular inflammation and were also found to have active macular CNV...
April 2017: American Journal of Ophthalmology Case Reports
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