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https://www.readbyqxmd.com/read/28230270/a-phase-2-study-of-lenalidomide-rituximab-cyclophosphamide-and-dexamethasone-lr-cd-for-untreated-low-grade-non-hodgkin-lymphoma-requiring-therapy
#1
Allison Rosenthal, Amylou C Dueck, Stephen Ansell, Katherine Gano, Christopher Conley, Grzegorz S Nowakowski, John Camoriano, Jose F Leis, Joseph R Mikhael, A Keith Stewart, David Inwards, David Dingli, Shaji Kumar, Pierre Noel, Morie Gertz, Luis Porrata, Stephen Russell, Joseph Colgan, Rafael Fonseca, Thomas M Habermann, Prashant Kapoor, Francis Buadi, Nelson Leung, Rodger Tiedemann, Thomas E Witzig, Craig Reeder
Patients with indolent NHL have multiple treatment options yet there is no consensus as to the best initial therapy. Lenalidomide, an immunomodulatory agent, has single agent activity in relapsed lymphoma. This trial was conducted to assess feasibility, efficacy and safety of adding lenalidomide to rituximab, cyclophosphamide, and dexamethasone (LR-CD) in untreated indolent NHL patients requiring therapy. This was a single institution phase II trial. Treatment consisted of IV rituximab 375mg/m(2) day 1, oral lenalidomide 20mg days 1-21, cyclophosphamide 250mg/m(2) days 1, 8, 15, and dexamethasone 40mg days 1, 8, 15, 22, of a 28-day cycle...
February 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28228127/a-review-of-enhanced-paramedic-roles-during-and-after-hospital-handover-of-stroke-myocardial-infarction-and-trauma-patients
#2
Darren Flynn, Richard Francis, Shannon Robalino, Joanne Lally, Helen Snooks, Helen Rodgers, Graham McClelland, Gary A Ford, Christopher Price
BACKGROUND: Ambulance paramedics play a critical role expediting patient access to emergency treatments. Standardised handover communication frameworks have led to improvements in accuracy and speed of information transfer but their impact upon time-critical scenarios is unclear. Patient outcomes might be improved by paramedics staying for a limited time after handover to assist with shared patient care. We aimed to categorize and synthesise data from studies describing development/extension of the ambulance-based paramedic role during and after handover for time-critical conditions (trauma, stroke and myocardial infarction)...
February 23, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28226307/racial-ethnic-and-weight-status-disparities-in-dieting-and-disordered-weight-control-behaviors-among-early-adolescents
#3
Rachel F Rodgers, Karen E Peterson, Anne T Hunt, Jennifer L Spadano-Gasbarro, Tracy K Richmond, Mary L Greaney, S Bryn Austin
BACKGROUND: This study examined whether racial/ethnic minority early adolescents with overweight/obesity are at increased risk of disordered weight control behaviors, defined as unhealthy behaviors aiming to control or modify shape and weight, ranging from self-induced vomiting to the use of dietary supplements. METHODS: U.S. Middle school children (n=12.511) provided self-report of gender, race/ethnicity, height, and weight as well as dieting and disordered weight control behaviors...
February 14, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28221276/a-comparison-of-self-reported-medication-adherence-to-concordance-between-part-d-claims-and-medication-possession
#4
Samuel T Savitz, Sally C Stearns, Lei Zhou, Emily Thudium, Khalid A Alburikan, Richard Tran, Jo E Rodgers
OBJECTIVE: Medicare Part D claims indicate medication purchased, but people who are not fully adherent may extend prescription use beyond the interval prescribed. This study assessed concordance between Part D claims and medication possession at a study visit in relation to self-reported medication adherence. MATERIALS AND METHODS: We matched Part D claims for 6 common medications to medications brought to a study visit in 2011-2013 for the Atherosclerosis Risk in Communities study...
February 17, 2017: Medical Care
https://www.readbyqxmd.com/read/28213860/epidemiology-of-stone-disease-across-the-world
#5
Igor Sorokin, Charalampos Mamoulakis, Katsuhito Miyazawa, Allen Rodgers, Jamsheer Talati, Yair Lotan
Nephrolithiasis is a highly prevalent disease worldwide with rates ranging from 7 to 13% in North America, 5-9% in Europe, and 1-5% in Asia. Due to high rates of new and recurrent stones, management of stones is expensive and the disease has a high level of acute and chronic morbidity. The goal of this study is to review the epidemiology of stone disease in order to improve patient care. A review of the literature was conducted through a search on Pubmed(®), Medline(®), and Google Scholar(®). This review was presented and peer-reviewed at the 3rd International Consultation on Stone Disease during the 2014 Société Internationale d'Urologie Congress in Glasgow...
February 17, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28213602/understanding-the-epidemiology-of-avoidable-significant-harm-in-primary-care-protocol-for-a-retrospective-cross-sectional-study
#6
Brian G Bell, Stephen Campbell, Andrew Carson-Stevens, Huw Prosser Evans, Alison Cooper, Christina Sheehan, Sarah Rodgers, Christine Johnson, Adrian Edwards, Sarah Armstrong, Rajnikant Mehta, Antony Chuter, Ailsa Donnelly, Darren M Ashcroft, Joanne Lymn, Pam Smith, Aziz Sheikh, Matthew Boyd, Anthony J Avery
INTRODUCTION: Most patient safety research has focused on specialist-care settings where there is an appreciation of the frequency and causes of medical errors, and the resulting burden of adverse events. There have, however, been few large-scale robust studies that have investigated the extent and severity of avoidable harm in primary care. To address this, we will conduct a 12-month retrospective cross-sectional study involving case note review of primary care patients. METHODS AND ANALYSIS: We will conduct electronic searches of general practice (GP) clinical computer systems to identify patients with avoidable significant harm...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28208048/guideline-for-the-diagnosis-and-management-of-hypertension-in-adults-2016
#7
Anthony Rodgers, Clara K Chow, Rodney T Jackson, Anushka Patel, Tim Usherwood
No abstract text is available yet for this article.
February 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28207260/theoretical-investigations-of-the-reactions-of-n-and-o-containing-species-on-a-c-100-h-2%C3%A3-1-reconstructed-diamond-surface
#8
Mark W Kelly, Sarah C Halliwell, W Jeff Rodgers, Jason D Pattle, Jeremy N Harvey, Michael N R Ashfold
Quantum mechanical and hybrid quantum mechanical/molecular mechanical (QM/MM) cluster models have been used to investigate possible reaction mechanisms whereby gas phase NHx (x = 0-2), CNHx (x = 0, 1) and OH radicals can add to, and incorporate in, a C-C dimer bond on the C(100):H 21 diamond surface during chemical vapor deposition from microwave activated C/H containing gas mixtures containing trace amounts of added N or O. Three N incorporation routes are identified, initiated by N, NH and CN(H) addition to a surface radical site, whereas only OH addition was considered as the precursor to O incorporation...
February 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28207069/continuum-of-care-for-hcv-among-patients-diagnosed-in-the-emergency-department-setting
#9
Erik S Anderson, James W Galbraith, Laura J Deering, Sarah K Pfeil, Tamara Todorovic, Joel B Rodgers, Jordan M Forsythe, Ricardo Franco, Henry Wang, N Ewen Wang, Douglas A E White
No abstract text is available yet for this article.
February 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28204717/hepatitis-c-virus-infections-associated-with-unsafe-injection-practices-at-a-pain-management-clinic-michigan-2014-2015
#10
Joseph R Coyle, Emily Goerge, Kathryn Kacynski, Ruby Rodgers, Patricia Raines, Linda S Vail, Sugandha Lowhim
No abstract text is available yet for this article.
February 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28203276/a-biorefinery-scheme-to-fractionate-bamboo-into-high-grade-dissolving-pulp-and-ethanol
#11
Zhaoyang Yuan, Yangbing Wen, Nuwan Sella Kapu, Rodger Beatson, D Mark Martinez
BACKGROUND: Bamboo is a highly abundant source of biomass which is underutilized despite having a chemical composition and fiber structure similar as wood. The main challenge for the industrial processing of bamboo is the high level of silica, which forms water-insoluble precipitates negetively affecting the process systems. A cost-competitive and eco-friendly scheme for the production of high-purity dissolving grade pulp from bamboo not only requires a process for silica removal, but also needs to fully utilize all of the materials dissolved in the process which includes lignin, and cellulosic and hemicellulosic sugars as well as the silica...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28202497/deficiency-of-the-angiotensinase-aminopeptidase-a-increases-susceptibility-to-glomerular-injury
#12
Juan Carlos Q Velez, Ehtesham Arif, Jessalyn Rodgers, Megan P Hicks, John M Arthur, Deepak Nihalani, Evelyn T Bruner, Milos N Budisavljevic, Carl Atkinson, Wayne R Fitzgibbon, Michael G Janech
Aminopeptidase A (APA) is expressed in glomerular podocytes and tubular epithelia and metabolizes angiotensin II (AngII), a peptide known to promote glomerulosclerosis. In this study, we tested whether APA expression changes in response to progressive nephron loss or whether APA exerts a protective role against glomerular damage and during AngII-mediated hypertensive kidney injury. At advanced stages of FSGS, fawn-hooded hypertensive rat kidneys exhibited distinctly increased APA staining in areas of intact glomerular capillary loops...
February 15, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28196577/ambiguity-within-nursing-practice-an-evolutionary-concept-analysis
#13
Michelle A McMahon, Nancy M Dluhy
PURPOSE: To analyze the concept of ambiguity in a nursing context. BACKGROUND: Ambiguity is inherent within nursing practice. As health care becomes increasingly complex, nurses must continue to successfully deal with greater amounts of clinical ambiguity. Although ambiguity is discussed in nursing, minimal concept refinement exists to capture the contextual intricacies from a nursing lens. Nurse perception of an ambiguous clinical event, in combination with nurse tolerance level for ambiguity, can impact nurse response...
February 1, 2017: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/28194845/enhancement-of-c-h-oxidizing-ability-in-co-o2-%C3%A2-complexes-through-an-isolated-heterobimetallic-oxo-intermediate
#14
Daniel E DeRosha, Brandon Q Mercado, Gudrun Lukat-Rodgers, Kenton R Rodgers, Patrick L Holland
The characterization of intermediates formed through the reaction of transition-metal complexes with dioxygen (O2 ) is important for understanding oxidation in biological and synthetic processes. Here, the reaction of the diketiminate-supported cobalt(I) complex L(tBu) Co with O2 gives a rare example of a side-on dioxygen complex of cobalt. Structural, spectroscopic, and computational data are most consistent with its assignment as a cobalt(III)-peroxo complex. Treatment of L(tBu) Co(O2 ) with low-valent Fe and Co diketiminate complexes affords isolable oxo species with M2 O2 "diamond" cores, including the first example of a crystallographically characterized heterobimetallic bis(μ-oxo) complex of two transition metals...
February 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28193586/influence-of-cuso4-and-chelated-copper-algaecide-exposures-on-biodegradation-of-microcystin-lr
#15
Kyla J Iwinski, John H Rodgers, Ciera M Kinley, Maas Hendrikse, Alyssa J Calomeni, Andrew D McQueen, Tyler D Geer, Jenny Liang, Vanessa Friesen, Monique Haakensen
Copper exposures from algaecide applications in aquatic systems are hypothesized to impede bacterial degradation of microcystin (MC), a cyanobacterial produced hepatotoxin. Despite regulatory implications of this hypothesis, limited data exist on influences of copper-exposures on MC-degrading bacteria and consequent MC-degradation. In this study, influences of copper-algaecide concentrations and formulations on bacterial composition and microcystin-LR (MCLR) degradation were investigated. Microcystis aeruginosa was exposed to four concentrations (0-5...
January 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28193549/identification-of-rare-hiv-1-group-n-hbv-ae-and-htlv-3-strains-in-rural-south-cameroon
#16
M A Rodgers, A S Vallari, B Harris, J Yamaguchi, V Holzmayer, K Forberg, M G Berg, J Kenmenge, C Ngansop, B Awazi, D Mbanya, L Kaptue, C Brennan, G Cloherty, N Ndembi
Surveillance of emerging viral variants is critical to ensuring that blood screening and diagnostic tests detect all infections regardless of strain or geographic location. In this study, we conducted serological and molecular surveillance to monitor the prevalence and diversity of HIV, HBV, and HTLV in South Cameroon. The prevalence of HIV was 8.53%, HBV was 10.45%, and HTLV was 1.04% amongst study participants. Molecular characterization of 555 HIV-1 specimens identified incredible diversity, including 7 subtypes, 12 CRFs, 6 unclassified, 24 Group O and 2 Group N infections...
February 10, 2017: Virology
https://www.readbyqxmd.com/read/28190578/quarter-dose-quadruple-combination-therapy-for-initial-treatment-of-hypertension-placebo-controlled-crossover-randomised-trial-and-systematic-review
#17
Clara K Chow, Jay Thakkar, Alex Bennett, Graham Hillis, Michael Burke, Tim Usherwood, Kha Vo, Kris Rogers, Emily Atkins, Ruth Webster, Michael Chou, Hakim-Moulay Dehbi, Abdul Salam, Anushka Patel, Bruce Neal, David Peiris, Henry Krum, John Chalmers, Mark Nelson, Christopher M Reid, Mark Woodward, Sarah Hilmer, Simon Thom, Anthony Rodgers
BACKGROUND: Globally, most patients with hypertension are treated with monotherapy, and control rates are poor because monotherapy only reduces blood pressure by around 9/5 mm Hg on average. There is a pressing need for blood pressure-control strategies with improved efficacy and tolerability. We aimed to assess whether ultra-low-dose combination therapy could meet these needs. METHODS: We did a randomised, placebo-controlled, double-blind, crossover trial of a quadpill-a single capsule containing four blood pressure-lowering drugs each at quarter-dose (irbesartan 37·5 mg, amlodipine 1·25 mg, hydrochlorothiazide 6·25 mg, and atenolol 12·5 mg)...
February 9, 2017: Lancet
https://www.readbyqxmd.com/read/28188464/brief-report-examination-of-correlates-of-adaptive-behavior-in-children-with-hfasd-using-the-basc-2-parent-rating-scale
#18
Christin A McDonald, James P Donnelly, Jonathan D Rodgers, Marcus L Thomeer, Christopher Lopata, Allyson K Jordan
This study extended the research on correlates of adaptive functioning of high-functioning children with autism spectrum disorder (HFASD) using the Behavior Assessment System for Children-Second Edition (BASC-2). Specifically, this study investigated the relationships between adaptive behavior and age, IQ, and ASD symptomology, in a well-characterized sample of 119 children with HFASD, ages 6-11 years. Results revealed age and IQ were not significantly correlated with adaptive ability. However, total autism symptoms [measured by the Autism Diagnostic Interview-Revised (ADI-R)], as well as ASD-social symptoms were negatively correlated with adaptive ability...
February 10, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28177175/complex-adaptive-systems-and-their-relevance-for-nursing-an-evolutionary-concept-analysis
#19
Ippolito Notarnicola, Cristina Petrucci, Maria Rosimar De Jesus Barbosa, Fabio Giorgi, Alessandro Stievano, Gennaro Rocco, Loreto Lancia
This study aimed to analyze the concept of "complex adaptive systems." The construct is still nebulous in the literature, and a further explanation of the idea is needed to have a shared knowledge of it. A concept analysis was conducted utilizing Rodgers evolutionary method. The inclusive years of bibliographic search started from 2005 to 2015. The search was conducted at PubMed©, CINAHL© 2017 John Wiley & Sons Australia, Ltd Nursing is a complex adaptive system, and the nursing profession in practice exhibits complex adaptive system characteristics...
February 8, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28176453/do-maternal-perceptions-of-child-eating-and-feeding-help-to-explain-the-disconnect-between-reported-and-observed-feeding-practices-a-follow-up-study
#20
Heidi J Bergmeier, Helen Skouteris, Marion M Hetherington, Rachel F Rodgers, Karen J Campbell, Rachael Cox
Research demonstrates a mismatch between reported and observed maternal feeding practices. This mismatch may be explained by maternal cognitions, attitudes, and motivations relating to dyadic parent-child feeding interactions. These complex constructs may not be apparent during observations nor evidenced in self-report questionnaire. Therefore, the aim of this study was to use a qualitative approach to gain a more nuanced and contextualized understanding of (a) maternal perceptions of children's food intake control; (b) how parent-child mealtime interactions influence maternal feeding practices; and (c) ways in which mothers may promote healthy child eating and weight outcomes...
February 8, 2017: Maternal & Child Nutrition
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