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https://www.readbyqxmd.com/read/28433546/symptom-trajectories-in-children-receiving-treatment-for-leukemia-a-latent-class-growth-analysis-with-multitrajectory-modeling
#1
Marilyn J Hockenberry, Mary C Hooke, Cheryl Rodgers, Olga Taylor, Kari M Koerner, Pauline Mitby, Ida Moore, Michael E Scheurer, Wei Pan
CONTEXT: Cancer treatment symptoms play a major role in determining the health of children with cancer. Symptom toxicity often results in complications, treatment delays, and therapy dose reductions that can compromise leukemia therapy and jeopardize chances for long-term survival. Critical to understanding symptom experiences during treatment is the need for exploration of "why" inter-individual symptom differences occur; this will determine who may be most susceptible to treatment toxicities...
April 19, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28430989/gene-fractionation-and-function-in-the-ancient-subgenomes-of-maize
#2
Simon Renny-Byfield, Eli Rodgers-Melnick, Jeffrey Ross-Ibarra
The maize genome experienced an ancient whole genome duplication approximately 10 million years ago and the duplicate subgenomes have since experienced reciprocal gene loss (fractionation) such that many genes have returned to single-copy status. This process has not affected the subgenomes equally; reduced gene expression in one of the subgenomes mitigates the consequences of mutations and gene deletions and is thought to drive higher rates of fractionation. Here we take advantage of published genome-wide SNP and phenotype association data to show that, in accordance with predictions of this model, paralogs with greater expression contribute more to phenotypic variation compared to their lowly expressed counterparts...
April 19, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28429818/piscirickettsia-salmonis-infection-in-cultured-lumpfish-cyclopterus-lumpus-l
#3
M Marcos-López, N M Ruane, F Scholz, M Bolton-Warberg, S O Mitchell, S Murphy O'Sullivan, A Irwin Moore, H D Rodger
A Piscirickettsia salmonis infection was diagnosed in lumpfish (Cyclopterus lumpus L.) juveniles held in a marine research facility on the west coast of Ireland. The main clinical signs and pathology included marked ascites, severe multifocal liver necrosis and severe diffuse inflammation and necrosis of the exocrine pancreas and peri-pancreatic adipose tissue. Numerous Piscirickettsia-like organisms were observed by histopathology in the affected organs, and the bacterial species was characterized by molecular analysis...
April 21, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28429080/effect-of-gpr84-deletion-on-obesity-and-diabetes-development-in-mice-fed-long-chain-or-medium-chain-fatty-acid-rich-diets
#4
Eugene Du Toit, Liam Browne, Helen Irving-Rodgers, Helen M Massa, Nicolette Fozzard, Michael P Jennings, Ian R Peak
PURPOSE: Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose intolerance is not well characterised. We set out to determine whether GPR84 expression influences obesity and glucose intolerance susceptibility in MCFA and LCFA rich diet fed mice...
April 20, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28423312/hgfa-is-an-injury-regulated-systemic-factor-that-induces-the-transition-of-stem-cells-into-galert
#5
Joseph T Rodgers, Matthew D Schroeder, Chanthia Ma, Thomas A Rando
The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into GAlert, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals that induce GAlert in stem cells have remained elusive. Here, we show that the injury-induced regulation of hepatocyte growth factor (HGF) proteolytic processing via the systemic protease, hepatocyte growth factor activator (HGFA), stimulates GAlert in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs)...
April 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28422614/electronic-follow-up-of-developing-world-cleft-patients-a-digital-dream
#6
Tom W M Walker, Ambika Chadha, William Rodgers, Caroline Mills, Peter Ayliffe
OBJECTIVE: To identify potential access to telemedicine follow-up of children with clefts operated on a humanitarian mission. METHODS: A cross-sectional study of parents of children presenting to a humanitarian cleft lip and palate mission in a Provincial Hospital in the Philippines. A purpose designed questionnaire was used to assess access to electronic and digital resources that could be used to aid follow-up. Forty-five (N = 45) parents of children having primary cleft lip and or palate surgery participated...
April 19, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28418275/factors-influencing-cochlear-patency-after-translabyrinthine-surgery
#7
Brian Rodgers, Emily Stucken, Aaron Metrailer, Eric Sargent
Objective To determine predictive factors for cochlear obliteration after translabyrinthine surgery for vestibular schwannoma. Study Design Case series with chart review. Setting Neurotology referral center. Subjects and Methods In total, 345 charts were reviewed, resulting in 103 patients who underwent translabyrinthine surgery between January 2010 and July 2015 and had postoperative magnetic resonance imaging (MRI) for review. Surveillance MRI performed after translabyrinthine resection of vestibular schwannomas was reviewed...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28416213/a-prospective-study-of-rivaroxaban-for-central-venous-catheter-associated-upper-extremity-deep-vein-thrombosis-in-cancer-patients-catheter-2
#8
G A Davies, A Lazo-Langner, E Gandara, M Rodger, V Tagalakis, M Louzada, R Corpuz, M J Kovacs
INTRODUCTION: Patients with cancer are at increased risk of thrombosis, particularly those with central venous catheter (CVC) placement, which may predispose to the development of upper extremity deep vein thrombosis (UEDVT). Standard treatment includes low molecular weight heparin (LMWH) or LMWH bridged to warfarin. The direct oral anticoagulants (DOACs) have become standard of care for uncomplicated venous thromboembolism (VTE), but research in patients with cancer is ongoing. OBJECTIVES: To assess rivaroxaban monotherapy in patients with cancer who develop UEDVT due to CVC for preservation of line function, and safety outcomes of VTE recurrence, bleeding risk and death...
April 6, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28416202/presenteeism-in-nursing-an-evolutionary-concept-analysis
#9
Jessica G Rainbow, Linsey M Steege
BACKGROUND: Presenteeism is an emerging concept in nursing that has been linked to increased health care costs, patient medication errors and falls, and negative nurse well-being. However, prior work has utilized various definitions and antecedents. Clarity on the significance, development, and consequences of presenteeism in nursing is needed. PURPOSE: This concept analysis seeks to understand the application of presenteeism within nursing workforce literature and in the broader workforce context...
March 11, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28414410/preparing-family-physicians-to-care-for-underserved-populations-a-historical-perspective
#10
Denise V Rodgers, Andrea L Wendling, George W Saba, Megan Ruth Mahoney, Joedrecka S Brown Speights
Family physicians have been involved in the care of rural and urban underserved populations since the founding of the specialty. In the early 1970s family medicine training programs specifically focused on training residents to work with the underserved were established in both urban and rural settings. Key to the success of these programs has been a specific focus on improving access to care, understanding and eliminating health disparities, cultural competency and behavioral science training that recognizes the challenges often faced by patients and families living in poor rural and urban areas of the country...
April 2017: Family Medicine
https://www.readbyqxmd.com/read/28412431/3d-morphological-changes-in-lv-and-rv-during-lvad-ramp-studies
#11
Karima Addetia, Nir Uriel, Francesco Maffessanti, Gabriel Sayer, Sirtaz Adatya, Gene H Kim, Nitasha Sarswat, Savitri Fedson, Diego Medvedofsky, Eric Kruse, Keith Collins, Daniel Rodgers, Takayoshi Ota, Valluvan Jeevanandam, Victor Mor-Avi, Daniel Burkhoff, Roberto M Lang
OBJECTIVES: The purpose of this study was to investigate the differential impact of the 2 most commonly available left ventricular assist device (LVAD) types on the right (RV) and left (LV) ventricles using 3-dimensional (3D) echocardiography-based analysis of ventricular morphology. BACKGROUND: LVADs have emerged as common therapy for advanced heart failure. Recent data suggest that the heart responds differently to speed settings in the 2 main devices available (HeartMate II [HMII], St Jude Medical, Pleasanton, California, and HVAD, HeartWare International, Framingham, Massachusetts)...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28410568/health-functional-ability-and-life-satisfaction-among-older-people-65-years-and-over-a-cross-sectional-study
#12
Vivien Rodgers, Stephen Neville, Steven La Grow
BACKGROUND: Satisfaction with life is a subjective and complex interplay of an older persons' perspective on their life achievements. Satisfaction with life, alongside health and functional ability are major contributors to successful ageing. AIM: This study explored the impact of increasing age on older people's perceptions of their health, functional ability and life satisfaction. METHODS: A cross-sectional survey of non-institutionalised older people (65+) was conducted (n = 542) in the Manawatu region of New Zealand...
April 14, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/28408241/maternal-retinoids-increase-pdgfr%C3%AE-progenitor-population-and-beige-adipogenesis-in-progeny-by-stimulating-vascular-development
#13
Bo Wang, Xing Fu, Xingwei Liang, Zhixiu Wang, Qiyuan Yang, Tiande Zou, Wei Nie, Junxing Zhao, Pengfei Gao, Mei-Jun Zhu, Jeanene M de Avila, Joseph Maricelli, Buel D Rodgers, Min Du
Maternal vitamin A intake varies but its impact on offspring metabolic health is unknown. Here we found that maternal vitamin A or retinoic acid (RA) administration expanded PDGFRα(+) adipose progenitor population in progeny, accompanied by increased blood vessel density and enhanced brown-like (beige) phenotype in adipose tissue, protecting offspring from obesity. Blockage of retinoic acid signaling by either BMS493 or negative RA receptor (RARαDN) over-expression abolished the increase in blood vessel density, adipose progenitor population, and beige adipogenesis stimulated by RA...
April 4, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28406624/flame-retardant-chemicals-in-college-dormitories-flammability-standards-influence-dust-concentrations
#14
Robin E Dodson, Kathryn M Rodgers, Gale Carey, Jose Guillermo Cedeno Laurent, Adrian Covaci, Giulia Poma, Govindan Malarvannan, John D Spengler, Ruthann A Rudel, Joseph G Allen
Furniture flammability standards are typically met with chemical flame retardants (FRs). FRs can migrate out of products into dust and are linked to cancer, neurological impairment, and endocrine disruption. We collected 95 dust samples from dormitory common areas and student rooms on two U.S. college campuses adhering to two different furniture flammability standards: Technical Bulletin 117 (TB117) and Technical Bulletin 133 (TB133). Because TB133 requires furniture to withstand a much-more-demanding test flame than TB117, we hypothesized that spaces with TB133 furniture would have higher levels of FRs in dust...
April 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28400247/quality-of-life-dyspnea-and-functional-exercise-capacity-following-a-first-episode-of-pulmonary-embolism-results-of-the-elope-cohort-study
#15
Susan R Kahn, Arash Akaberi, John T Granton, David R Anderson, Philip S Wells, Marc A Rodger, Susan Solymoss, Michael J Kovacs, Lawrence Rudski, Avi Shimony, Carole Dennie, Chris Rush, Paul Hernandez, Shawn D Aaron, Andrew M Hirsch
BACKGROUND: We aimed to evaluate health-related quality of life (QOL), dyspnea and functional exercise capacity during the year following the diagnosis of a first episode of pulmonary embolism. METHODS: Prospective multicenter cohort study of 100 patients with acute pulmonary embolism recruited at 5 Canadian hospitals from 2010-2013. We measured the outcomes QOL (by SF-36 and PEmb-QOL measures), dyspnea (by the University of California San Diego Shortness of Breath Questionnaire (SOBQ)) and six-minute walk distance at Baseline, 1, 3, 6, and 12 months after acute pulmonary embolism...
April 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28398891/talking-to-patients-and-relatives-about-dying
#16
Rodger Charlton
No abstract text is available yet for this article.
April 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28393292/comparisons-of-the-factor-structure-and-measurement-invariance-of-the-spence-children-s-anxiety-scale-parent-version-in-children-with-autism-spectrum-disorder-and-typically-developing-anxious-children
#17
Magdalena Glod, Cathy Creswell, Polly Waite, Ruth Jamieson, Helen McConachie, Mikle Don South, Jacqui Rodgers
The Spence Children's Anxiety Scale-Parent version (SCAS-P) is often used to assess anxiety in children with autism spectrum disorder (ASD), however, little is known about the validity of the tool in this population. The aim of this study was to determine whether the SCAS-P has the same factorial validity in a sample of young people with ASD (n = 285), compared to a sample of typically developing young people with anxiety disorders (n = 224). Poor model fit with all of the six hypothesised models precluded invariance testing...
April 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28391436/parylene-scaffold-for-cartilage-lesion
#18
Carlos Eduardo da Silveira Franciozi, Carleton Thomas Vangsness, James Eugene Tibone, Juan Carlos Martinez, Damien Rodger, Tzu-Chieh Chou, Yu-Chong Tai, Rodrigo Brant, Ling Wu, Rene Jorge Abdalla, Bo Han, Denis Evseenko, Mark Humayun
Evaluate parylene scaffold feasibility in cartilage lesion treatment, introducing a novel paradigm combining a reparative and superficial reconstructive procedure. Fifteen rabbits were used. All animals had both knees operated and the same osteochondral lesion model was created bilaterally. The parylene scaffold was implanted in the right knee, and the left knee of the same animal was used as control. The animals were euthanized at different time points after surgery: four animals at three weeks, three animals at six weeks, four animals at nine weeks, and four animals at 12 weeks...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28383632/measuring-change-in-symptoms-of-neurobehavioural-disability-responsiveness-of-the-st-andrew-s-swansea-neurobehavioural-outcome-scale
#19
Nick Alderman, Claire Williams, Caroline Knight, Rodger Ll Wood
Objective: Neurobehavioural disability (NBD) after acquired brain injury (ABI) is often associated with poor outcome. The "St Andrew's-Swansea Neurobehavioural Outcome Scale" (SASNOS) was developed to measure NBD in a range of applications. Two of the "holy trinity" of psychometric properties, reliability and validity, have been comprehensively mapped, but the extent to which SASNOS meets the third, responsiveness, has not been investigated. Demonstrating responsiveness is essential in instruments employed in repeated measurement scenarios to confirm their ability to discriminate real change from error...
April 5, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28381283/consolidating-emerging-evidence-surrounding-hivst-and-hivss-a-rapid-systematic-mapping-protocol
#20
T Charles Witzel, Peter Weatherburn, Fiona M Burns, Cheryl C Johnson, Carmen Figueroa, Alison J Rodger
BACKGROUND: HIV self-testing (HIVST) is becoming popular with policy makers and commissioners globally, with a key aim of expanding access through reducing barriers to testing for individuals at risk of HIV infection. HIV self-sampling (HIVSS) was available previously to self-testing but was confined mainly to the USA and the UK. It remains to be seen whether the momentum behind HIVST will also energise efforts to expand HIVSS. Recent years have seen a rapid growth in the type of evidence related to these interventions as well as several systematic reviews...
April 5, 2017: Systematic Reviews
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