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https://www.readbyqxmd.com/read/28641926/targeting-the-gm-csf-receptor-for-the-treatment-of-cns-autoimmunity
#1
Igal Ifergan, Todd S Davidson, Hania Kebir, Dan Xu, Daphne Palacios-Macapagal, Jennifer Cann, Jane M Rodgers, Zoe N Hunter, Camille L Pittet, Sara Beddow, Clare A Jones, Alexandre Prat, Matthew A Sleeman, Stephen D Miller
In multiple sclerosis (MS), there is a growing interest in inhibiting the pro-inflammatory effects of granulocyte-macrophage colony-stimulating factor (GM-CSF). We sought to evaluate the therapeutic potential and underlying mechanisms of GM-CSF receptor alpha (Rα) blockade in animal models of MS. We show that GM-CSF signaling inhibition at peak of chronic experimental autoimmune encephalomyelitis (EAE) results in amelioration of disease progression. Similarly, GM-CSF Rα blockade in relapsing-remitting (RR)-EAE model prevented disease relapses and inhibited T cell responses specific for both the inducing and spread myelin peptides, while reducing activation of mDCs and inflammatory monocytes...
June 19, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28636879/delineating-neuroinflammation-parasite-cns-invasion-and-blood-brain-barrier-dysfunction-in-an-experimental-murine-model-of-human-african-trypanosomiasis
#2
Jean Rodgers, Barbara Bradley, Peter G E Kennedy
Although Trypanosoma brucei spp. was first detected by Aldo Castellani in CSF samples taken from sleeping sickness patients over a century ago there is still a great deal of debate surrounding the timing, route and effects of transmigration of the parasite from the blood to the CNS. In this investigation, we have applied contrast-enhance magnetic resonance imaging (MRI) to study the effects of trypanosome infection on the blood-brain barrier (BBB) in the well-established GVR35 mouse model of sleeping sickness...
June 18, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28634653/assessing-the-combined-toxicity-of-bmaa-and-its-isomers-2-4-dab-and-aeg-in-vitro-using-human-neuroblastoma-cells
#3
Brendan J Main, Kenneth J Rodgers
The non-protein amino acid (NPAA) ß-methylamino-L-alanine (BMAA) is produced by a diverse range of cyanobacteria, diatoms and dinoflagellates, and is present in both aquatic and terrestrial ecosystems globally. Exposure to BMAA has been implicated in the development of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD). BMAA is often found in nature along with its structural isomers 2,4-diaminobutyric acid (2,4-DAB) and aminoethylglycine (AEG); however, the toxicity of these NPAAs in combination has not been examined...
June 20, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28624361/low-intensity-rtms-has-sex-dependent-effects-on-the-local-response-of-glia-following-a-penetrating-cortical-stab-injury
#4
Darren Clarke, Marissa A Penrose, Alan R Harvey, Jennifer Rodger, Kristyn A Bates
Repetitive transcranial magnetic stimulation (rTMS), a non-invasive form of brain stimulation, has shown experimental and clinical efficacy in a range of neuromodulatory models, even when delivered at low intensity (i.e. subthreshold for action potential generation). After central nervous system (CNS) injury, studies suggest that reactive astrocytes and microglia can have detrimental but also beneficial effects; thus modulating glial activity, for example through application of rTMS, could potentially be a useful therapeutic tool following neurotrauma...
June 15, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28623397/different-effects-of-%C3%AE-linolenic-acid-gla-supplementation-on-plasma-and-red-blood-cell-phospholipid-fatty-acid-composition-and-calcium-oxalate-kidney-stone-risk-factors-in-healthy-subjects-from-two-race-groups-with-different-risk-profiles-pose-questions-about
#5
Allen L Rodgers, Dalielah Jappie-Mahomed, Paul J van Jaarsveld
Fatty acid (FA) composition of phospholipids in plasma and red blood cells (RBC) can influence calciuria, oxaluria and renal stone formation. In this regard, the ratio of arachidonic acid (AA) and its precursor linoleic acid (LA) appears to be important. Administration of γ-linolenic acid (GLA) has been shown to increase the concentration of dihomo-gamma linoleic acid (DGLA) relative to AA indicating that it may attenuate biosynthesis of the latter. Such effects have not been investigated in race groups having difference stone occurrence rates...
June 16, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28621259/clinical-effectiveness-and-cost-effectiveness-of-a-multifaceted-podiatry-intervention-for-falls-prevention-in-older-people-a-multicentre-cohort-randomised-controlled-trial-the-reducing-falls-with-orthoses-and-a-multifaceted-podiatry-intervention-trial
#6
Sarah Cockayne, Sara Rodgers, Lorraine Green, Caroline Fairhurst, Joy Adamson, Arabella Scantlebury, Belen Corbacho, Catherine E Hewitt, Kate Hicks, Robin Hull, Anne-Maree Keenan, Sarah E Lamb, Caroline McIntosh, Hylton B Menz, Anthony Redmond, Zoe Richardson, Wesley Vernon, Judith Watson, David J Torgerson
BACKGROUND: Falls are a serious cause of morbidity and cost to individuals and society. Evidence suggests that foot problems and inappropriate footwear may increase the risk of falling. Podiatric interventions could help reduce falls; however, there is limited evidence regarding their clinical effectiveness and cost-effectiveness. OBJECTIVES: To determine the clinical effectiveness and cost-effectiveness of a multifaceted podiatry intervention for preventing falls in community-dwelling older people at risk of falling, relative to usual care...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28619959/defining-asthma-and-assessing-asthma-outcomes-using-electronic-health-record-data-a-systematic-scoping-review
#7
Mohammad A Al Sallakh, Eleftheria Vasileiou, Sarah E Rodgers, Ronan A Lyons, Aziz Sheikh, Gwyneth A Davies
There is currently no consensus on approaches to defining asthma or assessing asthma outcomes using electronic health record-derived data. We explored these approaches in the recent literature and examined the clarity of reporting.We systematically searched for asthma-related articles published between January 1, 2014 and December 31, 2015, extracted the algorithms used to identify asthma patients and assess severity, control and exacerbations, and examined how the validity of these outcomes was justified.From 113 eligible articles, we found significant heterogeneity in the algorithms used to define asthma (n=66 different algorithms), severity (n=18), control (n=9) and exacerbations (n=24)...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28617596/review-of-organic-wastewater-compound-concentrations-and-removal-in-onsite-wastewater-treatment-systems
#8
Laurel A Schaider, Kathryn M Rodgers, Ruthann A Rudel
Onsite wastewater treatment systems, such as septic systems, serve 20% of U.S. households and are common in areas not served by wastewater treatment plants (WWTPs) globally. They can be sources of nutrients and pathogen pollution and have been linked to health effects in communities where they contaminate drinking water. However, few studies have evaluated their ability to remove organic wastewater compounds (OWCs) such as pharmaceuticals, hormones, and detergents. We synthesized results from 20 studies of 45 OWCs in conventional drainfield-based and alternative onsite wastewater treatment systems to characterize concentrations and removal...
June 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28614796/%C3%AE-synuclein-in-gut-endocrine-cells-and-its-implications-for-parkinson-s-disease
#9
Rashmi Chandra, Annie Hiniker, Yien-Ming Kuo, Robert L Nussbaum, Rodger A Liddle
Parkinson's disease (PD) is a progressive neurodegenerative disease with devastating clinical manifestations. In PD, neuronal death is associated with intracellular aggregates of the neuronal protein α-synuclein known as Lewy bodies. Although the cause of sporadic PD is not well understood, abundant clinical and pathological evidence show that misfolded α-synuclein is found in enteric nerves before it appears in the brain. This suggests a model in which PD pathology originates in the gut and spreads to the central nervous system via cell-to-cell prion-like propagation, such that transfer of misfolded α-synuclein initiates misfolding of native α-synuclein in recipient cells...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28609409/evolutionary-analysis-of-the-concept-of-comfort
#10
Sara Pinto, Sílvia Caldeira, José Carlos Martins, Beth Rodgers
Although comfort is cited as an important component of nursing care, a definition that provides a firm conceptual foundation for research and nursing science is still needed, particularly in nursing classifications and taxonomies. This article provides a clear and evidence-based definition, improving research, development, and implementation of specific nursing interventions.
July 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/28608592/tuning-the-porphyrin-building-block-in-self-assembled-cages-for-branched-selective-hydroformylation-of-propene
#11
Xiaowu Wang, Sandra Nurttila, Wojciech Dzik, Rene Becker, Jody Rodgers, Joost Reek
In this study unprecedented regio-selectivity to the branched aldehyde product in hydroformylation of propene is attained upon embedding a rhodium complex in a supramolecular assembly, L2, formed by coordination-driven self-assembly of tris-(meta-pyridyl)-phosphine and zinc(II) porpholactones. The design of the new capsule is based on the ligand-template approach, in which the ligand acts as a template for the capsule formation. Previously we have reported the first generation capsule L1, in which zinc(II) porphyrin units were utilized instead of porpholactones...
June 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28604875/fermi-resonance-as-a-means-to-determine-the-hydrogen-bonding-status-of-two-infrared-probes
#12
Jeffrey M Rodgers, Rachel M Abaskharon, Bei Ding, Jianxin Chen, Wenkai Zhang, Feng Gai
The C[double bond, length as m-dash]O/C[triple bond, length as m-dash]N stretching vibration arising from a carbonyl/nitrile functional group in various molecular systems has been frequently used to assess, for example, local hydrogen-bonding interactions, among other applications. However, in practice it is not always easy to ascertain whether the carbonyl or nitrile group in question is engaged in such interactions. Herein, we use 4-cyanoindole and cyclopentanone as models to show that, when a fundamental C[double bond, length as m-dash]O or C[triple bond, length as m-dash]N stretching mode is involved in Fermi resonance, the underlying vibrational coupling constant (W) is a convenient reporter of the hydrogen-bonding status of the corresponding carbonyl or nitrile group...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28604571/hvad-waveform-analysis-as-a-noninvasive-marker-of-pulmonary-capillary-wedge-pressure-a-first-step-toward-the-development-of-a-smart-left-ventricular-assist-device-pump
#13
Jonathan Grinstein, Daniel Rodgers, Sara Kalantari, Gabriel Sayer, Gene H Kim, Nitasha Sarswat, Sirtaz Adatya, Takeyoshi Ota, Valluvan Jeevanandam, Daniel Burkhoff, Nir Uriel
Flow waveforms are an important feature of the HVAD left ventricular assist device (LVAD) that provides information about HVAD function and patient hemodynamics. We assessed the properties of one specific aspect of the waveform, the slope of the ventricular filling phase (VFP), and its correlation with pulmonary capillary wedge pressure (PCWP). A total of 101 screenshots from the HVAD monitor and simultaneous hemodynamic measurements were obtained simultaneously during sequential stages of invasive hemodynamic ramp studies...
June 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28600903/oxidised-protein-metabolism-recent-insights
#14
Kate Samardzic, Kenneth J Rodgers
The 'oxygen paradox' arises from the fact that oxygen, the molecule that aerobic life depends on, threatens its very existence. An oxygen rich environment provided life on Earth with more efficient bioenergetics and, with it, the challenge of having to deal with a host of oxygenderived reactive species capable of damaging proteins and other crucial cellular components. In this Minireview we explore recent insights into the metabolism of proteins that have been reversibly or irreversibly damaged by oxygen-derived species...
June 9, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28599254/differences-in-patterns-of-physical-participation-in-recreational-activities-between-children-with-and-without-intellectual-and-developmental-disability
#15
Chi-Wen Chien, Sylvia Rodger, Jodie Copley
BACKGROUND: Children with intellectual and developmental disability (IDD) are at risk of experiencing limited participation in recreational activities, where they may be present but not physically engaged. AIM: To compare patterns of physical engagement in recreational activities between children with and without IDD. METHODS AND PROCEDURES: Fifty children with IDD (26 boys, 24 girls; mean age 8.7 years) were matched for age and sex with 50 typically developing children...
June 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28598903/self-reported-difficulties-with-everyday-function-cognitive-symptoms-and-cognitive-function-in-people-with-hiv
#16
Rosanna Laverick, Lewis Haddow, Marina Daskalopoulou, Fiona Lampe, Richard Gilson, Andrew Speakman, Andrea Antinori, Tina Bruun, Anna Vassilenko, Simon Collins, Alison Rodger
BACKGROUND: We determined factors associated with self-reported decline in activities of daily living (ADLs) and symptoms of cognitive impairment in HIV positive (HIV+) adults in five European clinics. METHODS: HIV+ adults underwent computerized and pen-and-paper neuropsychological tests and questionnaires of cognitive symptoms and ADLs. We considered cognitive function in five domains, psychosocial factors and clinical parameters as potentially associated with symptoms...
June 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28598011/an-evolutionary-concept-analysis-of-compassion-fatigue
#17
Claire Sorenson, Beth Bolick, Karen Wright, Rebekah Hamilton
PURPOSE: The purpose of this article is to fill the need for an updated concept analysis of compassion fatigue. METHODS: This review used Rodgers' Evolutionary Model to direct the analysis of 25 papers published between 2005 and 2015. This review focused strictly on healthcare providers in the formal healthcare setting. CONCLUSIONS: The authors provided an analysis of the evolution of compassion fatigue and identified surrogate terms, attributes and defining characteristics, and antecedents and consequences of the term, true to Rodgers' Evolutionary Model...
June 9, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28593595/psychometric-properties-of-the-adapted-skillstreaming-checklist-for-high-functioning-children-with-asd
#18
Christopher Lopata, Jonathan D Rodgers, James P Donnelly, Marcus L Thomeer, Christin A McDonald, Martin A Volker
This study examined the reliability and criterion-related validity of parent ratings on the Adapted Skillstreaming Checklist (ASC) for a sample of 275 high-functioning children, ages 6-12 years, with ASD. Internal consistency for the total sample was 0.92. For two subsamples, test-retest reliability was very good at the 6-week and good at the 9-month intervals. Child age, IQ, and language abilities were unrelated to the ASC score. The ASC total score was inversely and strongly related to parent ratings of ASD symptom severity...
June 7, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28592317/modeling-the-spatio-temporal-dynamics-of-porcine-reproductive-respiratory-syndrome-cases-at-farm-level-using-geographical-distance-and-pig-trade-network-matrices
#19
Sara Amirpour Haredasht, Dale Polson, Rodger Main, Kyuyoung Lee, Derald Holtkamp, Beatriz Martínez-López
BACKGROUND: Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating infectious diseases for the swine industry. A better understanding of the disease dynamics and the transmission pathways under diverse epidemiological scenarios is a key for the successful PRRS control and elimination in endemic settings. In this paper we used a two step parameter-driven (PD) Bayesian approach to model the spatio-temporal dynamics of PRRS and predict the PRRS status on farm in subsequent time periods in an endemic setting in the US...
June 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28589397/therapeutic-value-of-standard-versus-extended-pelvic-lymph-node-dissection-during-radical-prostatectomy-for-high-risk-prostate-cancer
#20
REVIEW
Michele Colicchia, Vidit Sharma, Firas Abdollah, Alberto Briganti, R Jeffrey Karnes
Extent of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains a subject of debate. Here, we review the literature covering the value of extended PLND (ePLND) during RP for high-risk prostate cancer (PCa) over a standard PLND, with a focus on potential therapeutic advantage. PLND may provide valuable prognostic information to high-risk PCa patients, and incorporating the common iliac and presacral nodes to ePLND templates further improves pathologic nodal staging accuracy. Although increased PLND extent is associated with increased lymphocele/lymphedema rates, it is not associated with increased venous thromboembolism rates...
July 2017: Current Urology Reports
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