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https://www.readbyqxmd.com/read/29333852/synthesis-of-mip-nanoparticles-for-%C3%AE-casein-detection-using-spr-as-a-milk-allergen-sensor
#1
Jon Ashley, Yunus Shukor, Roberta D'Aurelio, Linda Trinh, Thomas Lawrence Rodgers, Jeff Temblay, Mike Pleasants, Ibtisam E Tothill
Food recalls due to undeclared allergens or contamination are costly to the food manufacturing industry worldwide. As the industry strives for better manufacturing efficiencies over a diverse range of food products, there is a need for the development of new analytical techniques to improve monitoring the presence of unintended food allergens during the food manufacturing process. In particular, the monitoring of wash samples from cleaning in place systems (CIP), used in the cleaning of food processing equipment, would allow for the effective removal of allergen containing ingredients in between food batches...
January 15, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29331385/guidelines-of-care-for-the-management-of-basal-cell-carcinoma
#2
Christian Baum, Jeremy S Bordeaux, Marc Brown, Klaus J Busam, Daniel B Eisen, Vivek Iyengar, Clifford Lober, David J Margolis, Jane Messina, Alexander Miller, Stanley Miller, Eliot Mostow, Christen Mowad, Kishwer Nehal, Kristi Schmitt-Burr, Aleksandar Sekulic, Paul Storrs, Joyce Teng, Siegrid Yu, Conway Huang, Kevin Boyer, Wendy Smith Begolka, Murad Alam, John Y S Kim, Jeffrey H Kozlow, Bharat Mittal, Jeffrey Moyer, Thomas Olencki, Phillip Rodgers
Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. We discuss biopsy techniques for a clinically suspicious lesion and offer recommendations for the histopathologic interpretation of BCC...
January 3, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29321033/environmental-enrichment-intervention-for-rett-syndrome-an-individually-randomised-stepped-wedge-trial
#3
Jenny Downs, Jenny Rodger, Chen Li, Xuesong Tan, Nan Hu, Kingsley Wong, Nicholas de Klerk, Helen Leonard
BACKGROUND: Rett syndrome is caused by a pathogenic mutation in the MECP2 gene with major consequences for motor and cognitive development. One of the effects of impaired MECP2 function is reduced production of Brain Derived Neurotrophic Factor (BDNF), a protein required for normal neuronal development. When housed in an enriched environment, MECP2 null mice improved motor abilities and increased levels of BDNF in the brain. We investigated the effects of environmental enrichment on gross motor skills and blood BDNF levels in girls with Rett syndrome...
January 10, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29314266/fluorescence-detected-linear-dichroism-spectroscopy-a-selective-and-sensitive-probe-for-fluorophores-in-flow-oriented-systems
#4
Alan M Wemyss, Nikola P Chmel, Daniela P Lobo, John A Sutherland, Timothy R Dafforn, Alison Rodger
Fluorescence detection typically enhances sensitivity and selectivity for fluorescent analytes. The potential for combining fluorescence detection with flow orientation of the sample in the normal configuration of linear dichroism experiments is explored in this work by measuring the fluorescence emitted from flow-orientated DNA-bound ligands and M13 bacteriophage. Data for ethidium bromide, Hoechst 33258, and 4,6-diamidino-2-phenyindole are presented. The theoretical basis of the technique is also presented for instruments running in both the fixed direct-current mode, which is the normal operation mode of circular dichroism spectropolarimeters, and also in fixed high-tension voltage mode...
January 3, 2018: Chirality
https://www.readbyqxmd.com/read/29303558/21-tesla-ft-icr-mass-spectrometer-for-ultrahigh-resolution-analysis-of-complex-organic-mixtures
#5
Donald F Smith, David C Podgorski, Ryan P Rodgers, Greg T Blakney, Christopher L Hendrickson
We describe complex organic mixture analysis by 21 tesla (T) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Ultrahigh mass-resolving power (m/Δm50% > 2 700 000 at m/z 400) and mass accuracy (80 ppb rms) enable resolution and confident identification of tens of thousands of unique elemental compositions. We demonstrate 2.2-fold higher mass-resolving power, 2.6-fold better mass measurement accuracy, and 1.3-fold more assigned molecular formulas compared to our custom-built, state-of-the-art 9...
January 5, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29300688/psychology-science-and-knowledge-construction-broadening-perspectives-from-the-replication-crisis
#6
Patrick E Shrout, Joseph L Rodgers
Psychology advances knowledge by testing statistical hypotheses using empirical observations and data. The expectation is that most statistically significant findings can be replicated in new data and in new laboratories, but in practice many findings have replicated less often than expected, leading to claims of a replication crisis. We review recent methodological literature on questionable research practices, meta-analysis, and power analysis to explain the apparently high rates of failure to replicate. Psychologists can improve research practices to advance knowledge in ways that improve replicability...
January 4, 2018: Annual Review of Psychology
https://www.readbyqxmd.com/read/29289545/phylogenomic-analysis-of-fundulidae-teleostei-cyprinodotiformes-using-rna-sequencing-data
#7
Rachel Rodgers, Jennifer Roach, Noah Reid, Andrew Whitehead, David D Duvernell
Fishes of the New World cyprinodontiform family Fundulidae display a wide variety of tolerance to environmental conditions, making them a valuable model system for comparative, evolutionary, and environmental studies. Despite numerous attempts to resolve the phylogenetic relationships of family Fundulidae, the basal structure of the phylogeny remains unresolved. The lack of a robust and fully resolved phylogeny for family Fundulidae and its most speciose genus Fundulus is an impediment to future research. This study utilized novel RNA-sequencing data for phylogenetic inference among16 members of Fundulidae to better refine the basal nodes of the family and confront long-standing questions regarding (1) the monophyletic status of genus Fundulus, and validity of the Lucania and recently synonymized Adinia genera; (2) the relationship of the west coast endemic Fundulus parvipinnis and F...
December 28, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29289275/the-misfits-of-blood-coagulation
#8
EDITORIAL
Henri H Versteeg, Marc Rodger
No abstract text is available yet for this article.
January 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29283314/delayed-inhibition-of-tonic-inhibition-enhances-functional-recovery-following-experimental-ischemic-stroke
#9
James E Orfila, Himmat Grewal, Robert M Dietz, Frank Strnad, Takeru Shimizu, Myriam Moreno, Christian Schroeder, Joan Yonchek, Krista M Rodgers, Andra Dingman, Timothy J Bernard, Nidia Quillinan, Wendy B Macklin, Richard J Traystman, Paco S Herson
The current study focuses on the ability to improve cognitive function after stroke with interventions administered at delayed/chronic time points. In light of recent studies demonstrating delayed GABA antagonists improve motor function, we utilized electrophysiology, biochemistry and neurobehavioral methods to investigate the role of α5 GABAA receptors on hippocampal plasticity and functional recovery following ischemic stroke. Male C57Bl/6 mice were exposed to 45 min transient middle cerebral artery occlusion and analysis of synaptic and functional deficits performed 7 or 30 days after recovery...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29282241/balancing-sexual-expression-and-risk-of-harm-in-elderly-persons-with-dementia
#10
Jessica Abellard, Carla Rodgers, Alicia L Bales
Assessing decision-making capacity in older individuals with dementia, now known as major neurocognitive disorder (MND), is a complex and challenging endeavor. There is a dearth of literature that touches on the sensitive and controversial topic of sexuality in institutionalized settings, despite the rapid increase in the global population of older individuals. In this article, we assert that evaluations of sexual expression in institutionalized older individuals with MND is essential, as there are concerns specific to risks and benefits of sexual expression in elderly persons with MND that should be considered...
December 2017: Journal of the American Academy of Psychiatry and the Law
https://www.readbyqxmd.com/read/29282072/a-pilot-study-to-understand-feasibility-and-acceptability-of-stool-and-cord-blood-sample-collection-for-a-large-scale-longitudinal-birth-cohort
#11
S R Bailey, C L Townsend, H Dent, C Mallet, E Tsaliki, E M Riley, M Noursadeghi, T D Lawley, A J Rodger, P Brocklehurst, N Field
BACKGROUND: Few data are available to guide biological sample collection around the time of birth for large-scale birth cohorts. We are designing a large UK birth cohort to investigate the role of infection and the developing immune system in determining future health and disease. We undertook a pilot to develop methodology for the main study, gain practical experience of collecting samples, and understand the acceptability of sample collection to women in late pregnancy. METHODS: Between February-July 2014, we piloted the feasibility and acceptability of collecting maternal stool, baby stool and cord blood samples from participants recruited at prolonged pregnancy and planned pre-labour caesarean section clinics at University College London Hospital...
December 28, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29277413/behavioral-and-mental-health-risk-factor-profiles-among-diverse-primary-care-patients
#12
Beth A Glenn, Catherine M Crespi, Hector P Rodriguez, Narissa J Nonzee, Siobhan M Phillips, Sherri N Sheinfeld Gorin, Sallie Beth Johnson, Maria E Fernandez, Paul Estabrooks, Rodger Kessler, Dylan H Roby, Suzanne Heurtin-Roberts, Catherine L Rohweder, Marcia G Ory, Alex H Krist
Behavioral and mental health risk factors are prevalent among primary care patients and contribute substantially to premature morbidity and mortality and increased health care utilization and costs. Although prior studies have found most adults screen positive for multiple risk factors, limited research has attempted to identify factors that most commonly co-occur, which may guide future interventions. The purpose of this study was to identify subgroups of primary care patients with co-occurring risk factors and to examine sociodemographic characteristics associated with these subgroups...
December 22, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29274009/the-effects-of-a-peer-delivered-social-skills-intervention-for-adults-with-comorbid-down-syndrome-and-autism-spectrum-disorder
#13
Matthew A Cody Davis, Amy Spriggs, Alexis Rodgers, Jonathan Campbell
Deficits in social skills are often exhibited in individuals with comorbid Down syndrome (DS) and autism spectrum disorder (ASD), and there is a paucity of research to help guide intervention for this population. In the present study, a multiple probe study across behaviors, replicated across participants, assessed the effectiveness of peer-delivered simultaneous prompting in teaching socials skills to adults with DS-ASD using visual analysis techniques and Tau-U statistics to measure effect. Peer-mediators with DS and intellectual disability (ID) delivered simultaneous prompting sessions reliably (i...
December 22, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29273107/why-finding-a-treatment-for-alopecia%C3%A2-areata-is-important-a%C3%A2-multifaceted-perspective
#14
Angela Renee Rodgers
Alopecia areata is an autoimmune disease that alters one's appearance. Some define it as a cosmetic disease despite evidence that substantial psychosocial burden is associated with it. As a physician, support group leader, consultant for the National Alopecia Areata Foundation, and patient, I discuss the evidence behind the psychosocial impact of alopecia areata and the importance of comprehensive treatment.
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/29273079/united-kingdom-frozen-shoulder-trial-uk-frost-multi-centre-randomised-12-month-parallel-group-superiority-study-to-compare-the-clinical-and-cost-effectiveness-of-early-structured-physiotherapy-versus-manipulation-under-anaesthesia-versus-arthroscopic-capsular
#15
Stephen Brealey, Alison L Armstrong, Andrew Brooksbank, Andrew Jonathan Carr, Charalambos P Charalambous, Cushla Cooper, Belen Corbacho, Joseph Dias, Iona Donnelly, Lorna Goodchild, Catherine Hewitt, Ada Keding, Lucksy Kottam, Sarah E Lamb, Catriona McDaid, Matthew Northgraves, Gerry Richardson, Sara Rodgers, Sarwat Shah, Emma Sharp, Sally Spencer, David Torgerson, Francine Toye, Amar Rangan
BACKGROUND: Frozen shoulder (also known as adhesive capsulitis) occurs when the capsule, or the soft tissue envelope around the ball and socket shoulder joint, becomes scarred and contracted, making the shoulder tight, painful and stiff. It affects around 1 in 12 men and 1 in 10 women of working age. Although this condition can settle with time (typically taking 1 to 3 years), for some people it causes severe symptoms and needs referral to hospital. Our aim is to evaluate the clinical and cost-effectiveness of two invasive and costly surgical interventions that are commonly used in secondary care in the National Health Service (NHS) compared with a non-surgical comparator of Early Structured Physiotherapy...
December 22, 2017: Trials
https://www.readbyqxmd.com/read/29260092/bilateral-cavernous-sinus-thrombosis-with-septic-lung-lesions-resulting-from-a-nasal-abscess
#16
Matthew J Schear, Alexander Weiss, Rand Rodgers
No abstract text is available yet for this article.
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29250853/participation-in-school-related-activities-that-require-hand-use-for-children-with-and-without-developmental-disabilities
#17
M Cho, S Rodger, J Copley, C-W Chien
BACKGROUND: Children with developmental disabilities (DD) may experience limited participation in school activities. Little is known about whether school participation of children with DD who attend special schools is impacted. This study specifically focused on physical engagement in school-related activities that require hand use for the comparison between this group of children with DD and typically developing children. METHODS: The sample consisted of 97 children with DD who attended special schools (mean age 8...
December 18, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29249524/frequency-and-cost-of-vaccinations-administered-outside-minimum-and-maximum-recommended-ages-2014-data-from-6-sentinel-sites-of-immunization-information-systems
#18
Loren Rodgers, Lauren Shaw, Raymond Strikas, Beth Hibbs, JoEllen Wolicki, Cristina V Cardemil, Cindy Weinbaum
OBJECTIVE: To quantify vaccinations administered outside minimum and maximum recommended ages and to determine attendant costs of revaccination by analyzing immunization information system (IIS) records. STUDY DESIGN: We analyzed deidentified records of doses administered during 2014 to persons aged <18 years within 6 IIS sentinel sites (10% of the US population). We quantified doses administered outside of recommended ages according to the Advisory Committee on Immunization Practices childhood immunization schedule and prescribing information in package inserts, and calculated revaccination costs...
December 14, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29249085/correction-to-a-comparison-of-the-energetic-cost-of-running-in-marathon-racing-shoes
#19
Wouter Hoogkamer, Shalaya Kipp, Jesse H Frank, Emily M Farina, Geng Luo, Rodger Kram
An Online First version of this article was made available online at https://link.springer.com/article/10.1007/s40279-017-0811-2 on 16 November 2017. An error was subsequently identified in the article, and the following correction should be noted.
December 16, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29240635/the-etiology-of-male-urethral-discharge-in-zimbabwe-results-from-the-zimbabwe-sti-etiology-study
#20
Cornelis A Rietmeijer, More Mungati, Anna Machiha, Owen Mugurungi, Vitalis Kupara, Luanne Rodgers, Peter H Kilmarx, Amy Herman Roloff, Elizabeth Gonese, Beth A Tippett-Barr, Gerald Shambira, David A Lewis, H Hunter Handsfield, Mufuta Tshimanga
INTRODUCTION: Sexually transmitted infections (STIs) are managed syndromically in most developing countries. In Zimbabwe, men presenting with urethral discharge are treated with a single intramuscular dose of kanamycin or ceftriaxone in combination with a week's course of oral doxycycline. This study was designed to assess the current etiology of urethral discharge and other STIs to inform current syndromic management regimens. METHODS: We conducted a study among 200 men with urethral discharge presenting at 6 regionally diverse STI clinics in Zimbabwe...
January 2018: Sexually Transmitted Diseases
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