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https://www.readbyqxmd.com/read/28432040/usability-acceptability-and-adherence-to-an-electronic-self-monitoring-system-in-patients-with-major-depression-discharged-from-inpatient-wards
#1
Lise Lauritsen, Louise Andersen, Emilia Olsson, Stine Rauff Søndergaard, Lasse Benn Nørregaard, Philip Kaare Løventoft, Signe Dunker Svendsen, Erik Frøkjær, Hans Mørch Jensen, Ida Hageman, Lars Vedel Kessing, Klaus Martiny
BACKGROUND: Patients suffering from depression have a high risk of relapse and readmission in the weeks following discharge from inpatient wards. Electronic self-monitoring systems that offer patient-communication features are now available to offer daily support to patients, but the usability, acceptability, and adherence to these systems has only been sparsely investigated. OBJECTIVE: We aim to test the usability, acceptability, adherence, and clinical outcome of a newly developed computer-based electronic self-assessment system (the Daybuilder system) in patients suffering from depression, in the period from discharge until commencing outpatient treatment in the Intensive Outpatient Unit for Affective Disorders...
April 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28430035/noninvasive-neuromodulation-and-thalamic-mapping-with-low-intensity-focused-ultrasound
#2
Robert F Dallapiazza, Kelsie F Timbie, Stephen Holmberg, Jeremy Gatesman, M Beatriz Lopes, Richard J Price, G Wilson Miller, W Jeffrey Elias
OBJECTIVE Ultrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal. METHODS Ten Yorkshire swine ( Sus scrofa domesticus) were used in this study...
April 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28427522/the-role-of-anti-pd-1-and-anti-pd-l1-agents-in-the-treatment-of-diffuse-large-b-cell-lymphoma-the-future-is-now
#3
REVIEW
Luis Miguel Juárez-Salcedo, Jose Sandoval-Sus, Lubomir Sokol, Julio C Chavez, Samir Dalia
Immune checkpoints inhibitors have been incorporated into standard treatment protocols for advanced solid tumors. The aim of T-cell-based immune therapy in cancer has been to generate durable clinical benefits for patients, paired with enhanced side effect profiles. The beneficial antitumoral activity of programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) has been thoroughly demonstrated in certain metastatic malignancies (e.g. melanoma, non-small cell lung cancer, renal cell carcinoma); however, the therapeutic role in lymphoid cancers is complex...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28421807/los-antioxidantes-en-el-proceso-de-patolog%C3%A3-as-oculares
#4
Ana Fernández-Araque, Andrea Giaquinta Aranda, Consuelo Laudo Pardo, Abel Rojo Aragüés
Introducción: la influencia de los antioxidantes en los procesos oculares ha tomado en los últimos años una relevancia importante por sus efectos en la salud visual. El estrés oxidativo es un factor implicado en el desarrollo de las principales patologías tales como cataratas, glaucoma y degeneración macular asociada a la edad (DMAE).Objetivo: establecer la evidencia científica que existe sobre los distintos tipos de antioxidantes y sus efectos en procesos patológicos oculares mediante una revisión sistemática...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28420604/a-digital-tool-to-promote-alcohol-and-drug-use-screening-brief-intervention-and-referral-to-treatment-skill-translation-a-mobile-app-development-and-randomized-controlled-trial-protocol
#5
Derek D Satre, Khanh Ly, Maria Wamsley, Alexa Curtis, Jason Satterfield
BACKGROUND: Translation of knowledge and skills from classroom settings to clinical practice is a major challenge in healthcare training, especially for behavioral interventions. For example, screening, brief intervention, and referral to treatment (SBIRT) is a highly-promoted approach to identifying and treating individuals at risk for alcohol or drug problems, yet effective, routine use of SBIRT has lagged. OBJECTIVE: The objective of this paper is to describe the development, pilot testing, and trial protocol of a mobile app based on the theory of planned behavior (TPB) to promote SBIRT skill translation and application...
April 18, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28412568/first-report-on-mrsa-cc398-recovered-from-wild-boars-in-the-north-of-portugal-are-we-facing-a-problem
#6
Margarida Sousa, Nuno Silva, Vera Manageiro, Sónia Ramos, António Coelho, David Gonçalves, Manuela Caniça, Carmen Torres, Gilberto Igrejas, Patrícia Poeta
The aim of the present study was to evaluate the resistance of Staphylococcus aureus recovered from wild boars, to analyze their genetic lineages, and to investigate the susceptibility to oxacillin. Samples from mouth and nose of 45 wild boars (Sus scrofa) were collected during hunt activity from November 2012 to January 2013 in the North of Portugal. S. aureus isolates were recovered from 30 of these samples (33%); one isolate/sample was further studied. The susceptibility of the isolates was tested by disk-diffusion test against 14 antimicrobial agents and minimal inhibitory concentration was used to test oxacillin according to EUCAST guidelines...
April 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28412163/electroencephalographic-responses-of-anaesthetized-pigs-sus-scrofa-to-tail-docking-using-clippers-or-cautery-iron-performed-at-2-or-20-days-of-age
#7
Nikki J Kells, Ngaio J Beausoleil, J Paul Chambers, Mhairi A Sutherland, Rebecca S Morrison, Craig B Johnson
OBJECTIVE: To compare electroencephalographic (EEG) responses of pigs to tail docking using clippers or cautery iron, performed at 2 or 20 days of age. STUDY DESIGN: Prospective, randomised controlled experimental study. ANIMALS: A total of 40 Large White x Landrace entire male pigs aged 2 (n=20) or 20 (n=20) days were randomly assigned to undergo tail docking using clippers or cautery iron. METHODS: Anaesthesia was induced and maintained with halothane delivered in oxygen...
February 24, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28407384/point-mutations-in-acetylcholinesterase-1-associated-with-chlorpyrifos-resistance-in-the-brown-planthopper-nilaparvata-lugens-st%C3%A3-l
#8
Y Zhang, B Yang, J Li, M Liu, Z Liu
Insecticide resistance frequently results from target-site insensitivity, such as point mutations in acetylcholinesterases (AChEs) for resistance to organophosphates and carbamates. From a field-originated population of Nilaparvata lugens, a major rice pest, a resistant population (R9) was obtained by nine-generation continuous selection with chlorpyrifos. From the same field population, a relatively susceptible population (S9) was also constructed through rearing without any insecticides. Compared to the susceptible strain, Sus [medium lethal dose (LC50 ) = 0...
April 13, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28407305/female-striated-urogenital-sphincter-contraction-measured-by-shear-wave-elastography-during-pelvic-floor-muscle-activation-proof-of-concept-and-validation
#9
Rafeef Aljuraifani, Ryan E Stafford, François Hug, Paul W Hodges
AIMS: Investigation of the function of the striated urogenital sphincter (SUS) is challenging because it is difficult to access and requires invasive measures. Ultrasound shear wave elastography (SWE) is a non-invasive real-time technique used to estimate tissue stiffness. As muscle stiffness can be used as an estimate of muscle force, SWE provides an opportunity to study contraction of the peri-urethral musculature. Validation of SWE to study SUS during functional tasks, such as pelvic floor muscle contractions, is required prior to application in clinical populations...
April 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28404981/characterization-of-the-transcriptional-and-metabolic-responses-of-pediatric-high-grade-gliomas-to-mtor-hif-1a-axis-inhibition
#10
Aurélia Nguyen, François Marie Moussallieh, Alan Mackay, A Ercument Cicek, Andres Coca, Marie Pierre Chenard, Noelle Weingertner, Benoit Lhermitte, Eric Letouzé, Eric Guérin, Erwan Pencreach, Sarah Jannier, Dominique Guenot, Izzie Jacques Namer, Chris Jones, Natacha Entz-Werlé
Pediatric high grade glioma (pHGGs), including sus-tentorial and diffuse intrinsic pontine gliomas, are known to have a very dismal prognosis. For instance, even an increased knowledge on molecular biology driving this brain tumor entity, there is no treatment able to cure those patients. Therefore, we were focusing on a translational pathway able to increase the cell resistance to treatment and to reprogram metabolically tumor cells, which are, then, adapting easily to a hypoxic microenvironment. To establish, the crucial role of the hypoxic pathways in pHGGs, we, first, assessed their protein and transcriptomic deregulations in a pediatric cohort of pHGGs and in pHGG's cell lines, cultured in both normoxic and hypoxic conditions...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404473/coding-accuracy-for-parkinson-s-disease-hospital-admissions-implications-for-healthcare-planning-in-the-uk
#11
S Muzerengi, C Rick, I Begaj, N Ives, F Evison, R L Woolley, C E Clarke
OBJECTIVES: Hospital Episode Statistics data are used for healthcare planning and hospital reimbursements. Reliability of these data is dependent on the accuracy of individual hospitals reporting Secondary Uses Service (SUS) which includes hospitalisation. The number and coding accuracy for Parkinson's disease hospital admissions at a tertiary centre in Birmingham was assessed. STUDY DESIGN: Retrospective, routine-data-based study. METHODS: A retrospective electronic database search for all Parkinson's disease patients admitted to the tertiary hospital over a 4-year period (2009-2013) was performed on the SUS database using International Classification of Disease codes, and on the local inpatient electronic prescription database, Prescription and Information Communications System, using medication prescriptions...
January 28, 2017: Public Health
https://www.readbyqxmd.com/read/28404221/mantle-cell-lymphoma-contemporary-diagnostic-and-treatment-perspectives-in-the-age-of-personalized-medicine
#12
REVIEW
Jose Sandoval-Sus, Eduardo M Sotomayor, Bijal D Shah
Mantle cell lymphoma is a clinically heterogeneous disease occurring within a heterogeneous patient population, highlighting a need for personalized therapy to ensure optimal outcomes. It is therefore critical to understand the benefits and risks associated with both intensive and deintensified approaches. In the following review we provide a therapeutic roadmap to strategically guide treatment for newly diagnosed and relapsed/refractory patients highlighting pivotal and recently published results involving known and novel therapies...
April 6, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28403340/fertility-rates-and-perinatal-outcomes-of-adolescent-pregnancies-a-retrospective-population-based-study
#13
Maria de Lourdes de Souza, Fiona Ann Lynn, Linda Johnston, Eduardo Cardoso Teixeira Tavares, Odaléa Maria Brüggemann, Lúcio José Botelho
Objective: analyze trends in fertility rates and associations with perinatal outcomes for adolescents in Santa Catarina, Brazil. Methods: a population-based study covering 2006 to 2013 was carried out to evaluate associations between perinatal outcomes and age groups, using odds ratios, and Chi-squared tests. Results: differences in the fertility rate among female adolescents across regions and time period were observed, ranging from 40.9 to 72...
April 6, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28403338/needs-of-family-caregivers-in-home-care-for-older-adults
#14
Carla Cristiane Becker Kottwitz Bierhals, Naiana Oliveira Dos Santos, Fernanda Laís Fengler, Kamila Dellamora Raubustt, Dorothy Anne Forbes, Lisiane Manganelli Girardi Paskulin
Objective: to reveal the felt and normative needs of primary family caregivers when providing instrumental support to older adults enrolled in a Home Care Program in a Primary Health Service in the South of Brazil. Methods: using Bradshaw's taxonomy of needs to explore the caregiver's felt needs (stated needs) and normative needs (defined by professionals), a mixed exploratory study was conducted in three steps: Descriptive quantitative phase with 39 older adults and their caregiver, using a data sheet based on patient records; Qualitative exploratory phase that included 21 caregiver interviews, analyzed by content analysis; Systematic observation, using an observation guide with 16 caregivers, analyzed by descriptive statistics...
April 6, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28403244/wild-inside-urban-wild-boar-select-natural-not-anthropogenic-food-resources
#15
Milena Stillfried, Pierre Gras, Matthias Busch, Konstantin Börner, Stephanie Kramer-Schadt, Sylvia Ortmann
Most wildlife species are urban avoiders, but some became urban utilizers and dwellers successfully living in cities. Often, they are assumed to be attracted into urban areas by easily accessible and highly energetic anthropogenic food sources. We macroscopically analysed stomachs of 247 wild boar (Sus scrofa, hereafter WB) from urban areas of Berlin and from the surrounding rural areas. From the stomach contents we determined as predictors of food quality modulus of fineness (MOF,), percentage of acid insoluble ash (AIA) and macronutrients such as amount of energy and percentage of protein, fat, fibre and starch...
2017: PloS One
https://www.readbyqxmd.com/read/28403233/cost-effectiveness-of-cetuximab-and-panitumumab-for-chemotherapy-refractory-metastatic-colorectal-cancer
#16
Adriana Camargo Carvalho, Frederico Leal, Andre Deeke Sasse
BACKGROUND: Cetuximab and panitumumab are monoclonal antibodies targeting the epidermal growth factor receptor. Both drugs are active against RAS wild type metastatic colorectal cancer after chemotherapy failure, with similar efficacy and toxicity profiles. However, their cost and limited survival benefits may compromise incorporation in the Brazilian public healthcare system, the Unified Heath System (Sistema Único de Saúde) (SUS). METHODS: A cost-effectiveness analysis was conducted using a Markov model from the Brazilian Public health perspective and a lifetime horizon in patients with RAS -wt mCRC...
2017: PloS One
https://www.readbyqxmd.com/read/28402008/genome-wide-association-studies-reveal-additional-related-loci-for-fatty-acid-composition-in-a-duroc-pig-multigenerational-population
#17
Shuji Sato, Yoshinobu Uemoto, Takashi Kikuchi, Sachiko Egawa, Kimiko Kohira, Tomomi Saito, Hironori Sakuma, Satoshi Miyashita, Shinji Arata, Keiichi Suzuki
The aim of the present study was to detect quantitative trait loci affecting fatty acid composition in back fat and intramuscular fat in a Duroc pig population comprising seventh-generation pedigrees using genome-wide association studies (GWAS). In total, 305 animals were genotyped using single nucleotide polymorphisms (SNPs) array and five selected SNPs from regions containing known candidate genes related to fatty acid synthesis or metabolism. In total, 24 genome-wide significant SNP regions were detected in 12 traits, and 76 genome-wide suggestive SNP regions were detected in 33 traits...
April 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28391650/identification-of-brucella-spp-in-feral-swine-sus-scrofa-at-abattoirs-in-texas-usa
#18
K Pedersen, N E Bauer, S Olsen, A M Arenas-Gamboa, A C Henry, T D Sibley, T Gidlewski
Various tissues, nasal swabs, urine and blood samples were collected from 376 feral swine at two federally inspected abattoirs in Texas during six separate sampling periods in 2015. Samples were tested for Brucella spp. by culture and serology. Brucella spp. were cultured from 13.0% of feral swine, and antibodies were detected in 9.8%. Only 32.7% of culture-positive feral swine were also antibody positive, and 43.2% of antibody-positive feral swine were culture positive. Approximately, the same number of males (14...
April 9, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28390503/randomized-controlled-trial-of-a-computerized-interactive-media-based-problem-solving-treatment-for-depression
#19
Luis R Sandoval, Jay C Buckey, Ricardo Ainslie, Martin Tombari, William Stone, Mark T Hegel
This study evaluated the efficacy of an interactive media-based, computer-delivered depression treatment program (imbPST) compared to a no-treatment control condition (NTC) in a parallel-group, randomized, controlled trial conducted in an outpatient psychiatric research clinic. 45 adult participants with major depressive disorder or dysthymia were randomized to receive either 6 weekly sessions of imbPST or no treatment (No Treatment Control; NTC). The primary outcome measure was the Beck Depression Inventory II (BDI-II)...
May 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28390027/insects-associated-with-pig-carrion-in-two-environments-of-the-brazilian-savanna
#20
L S de Faria, M L Paseto, M S Couri, C A Mello-Patiu, J Mendes
Studies of carrion fauna have increased in Brazil and have contributed to the knowledge of this fauna in the national territory. Brazil has continental dimensions and presents various biomes in its territorial area. Most of the carrion fauna have seldom been studied, and this is especially true for the Savanna or "Cerrado." The present research examined the fauna visiting carrion in two environments and two seasons in a rural area situated in a region of Cerrado in southeastern Brazil. The two environments studied were a pasture and a fragment of semi-deciduous forest...
April 8, 2017: Neotropical Entomology
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