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Microperimetry

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https://www.readbyqxmd.com/read/28221256/evaluation-of-macular-ischemia-in-eyes-with-branch-retinal-vein-occlusion-an-optical-coherence-tomography-angiography-study
#1
Shin Kadomoto, Yuki Muraoka, Sotaro Ooto, Yuko Miwa, Yuto Iida, Kiyoshi Suzuma, Tomoaki Murakami, Rima Ghashut, Akitaka Tsujikawa, Nagahisa Yoshimura
PURPOSE: To quantitatively assess macular morphology and perfusion status using optical coherence tomography, and optical coherence tomography angiography in eyes with branch retinal vein occlusion when macular edema has completely resolved, and to investigate the impact on visual function. METHODS: Thirty consecutive eyes with branch retinal vein occlusion-macular edema that resolved after treatment with intravitreal ranibizumab injections were included. Macular sensitivity was measured by microperimetry; defect length of foveal ellipsoid zone band was measured using optical coherence tomography; foveal avascular zone and parafoveal nonperfusion areas (NPA) were measured by optical coherence tomography angiography...
February 17, 2017: Retina
https://www.readbyqxmd.com/read/28195613/functional-and-morphological-evaluation-of-traumatized-eyes-with-berlin-s-edema-affecting-the-macula-using-mferg-microperimetry-and-sd-oct
#2
Joseph Daniel Boss, Joaquin Tosi, Inna Glybina, Asheesh Tewari, Gary W Abrams
BACKGROUND AND OBJECTIVE: To describe the structural and functional changes that occur in traumatic Berlin's edema involving the macula through assessment with multifocal electroretinogram (mfERG), microperimetry, fundus photography, and spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: Retrospective case series of five eyes from four patients with macular traumatic Berlin's edema. Patients underwent baseline mfERG (three eyes), MP1 microperimetry (three eyes), fundus photography (five eyes), and SD-OCT (five eyes)...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28180131/semiautomated-segmentation-and-analysis-of-retinal-layers-in-three-dimensional-spectral-domain-optical-coherence-tomography-images-of-patients-with-atrophic-age-related-macular-degeneration
#3
Zhihong Hu, Yue Shi, Kiran Nandanan, Srinivas R Sadda
Historically, regular drusen and geographic atrophy (GA) have been recognized as the hallmarks of nonneovascular age-related macular degeneration (AMD). Recent imaging developments have revealed another distinct nonneovascular AMD phenotype, reticular pseudodrusen (RPD). We develop an approach to semiautomatically quantify retinal surfaces associated with various AMD lesions (i.e., regular drusen, RPD, and GA) in spectral domain (SD) optical coherence tomography (OCT) images. More specifically, a graph-based algorithm was used to segment multiple retinal layers in SD-OCT volumes...
January 2017: Neurophotonics
https://www.readbyqxmd.com/read/28178068/features-of-the-macula-and-central-visual-field-and-fixation-pattern-in-patients-with-retinitis-pigmentosa
#4
Isil Sayman Muslubas, Murat Karacorlu, Serra Arf, Mumin Hocaoglu, Mehmet Giray Ersoz
PURPOSE: To evaluate macular features and fixation pattern in patients with retinitis pigmentosa (RP) compared with healthy controls, using spectral-domain optical coherence tomography and MP-1 microperimetry. METHODS: Eighty-one eyes of 81 patients with RP and 90 eyes of 90 healthy subjects were assessed. The central foveal thickness, subfoveal choroidal thickness, ellipsoid zone length, and the mean retinal sensitivities and fixation characteristics were evaluated by spectral-domain optical coherence tomography and MP-1 microperimetry...
February 7, 2017: Retina
https://www.readbyqxmd.com/read/28161925/the-use-of-microperimetry-to-detect-functional-progression-in-non-neovascular-age-related-macular-degeneration-a-systematic-review
#5
REVIEW
Evan N Wong, Avenell L Chew, William H Morgan, Praveen J Patel, Fred K Chen
We reviewed the current literature on the ability of microperimetry to detect non-neovascular age-related macular degeneration (AMD) disease progression. The index test was retinal sensitivity measurement assessed by microperimetry and comparators were other functional measures (best-corrected and low-luminance visual acuities, and fixation stability) and structural parameters [retinal thickness, choroidal thickness, and area of geographic atrophy (GA) determined by color fundus photographs, short-wave or near-infrared fundus autofluorescence]...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28161916/the-pathway-from-genes-to-gene-therapy-in-glaucoma-a-review-of-possibilities-for-using-genes-as-glaucoma-drugs
#6
REVIEW
Teresa Borrás
We reviewed the current literature on the ability of microperimetry to detect non-neovascular age-related macular degeneration (AMD) disease progression. The index test was retinal sensitivity measurement assessed by microperimetry and comparators were other functional measures (best-corrected and low-luminance visual acuities, and fixation stability) and structural parameters [retinal thickness, choroidal thickness, and area of geographic atrophy (GA) determined by color fundus photographs, short-wave or near-infrared fundus autofluorescence]...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28159970/the-clinical-phenotype-of-cnga3-related-achromatopsia-pretreatment-characterization-in-preparation-of-a-gene-replacement-therapy-trial
#7
Ditta Zobor, Annette Werner, Franco Stanzial, Francesco Benedicenti, Günther Rudolph, Ulrich Kellner, Christian Hamel, Sten Andréasson, Gergely Zobor, Torsten Strasser, Bernd Wissinger, Susanne Kohl, Eberhart Zrenner
Purpose: The purpose of this study was to clinically characterize patients with CNGA3-linked achromatopsia (CNGA3-ACHM) in preparation of a gene therapy trial. Methods: Thirty-six patients (age 7-56 years) with complete (cACHM) or incomplete (iACHM) CNGA3-ACHM were examined, including detailed psychophysical tests, extended electrophysiology, and assessment of morphology by fundus autofluorescence and spectral-domain optical coherence tomography (SD-OCT). Results: Mean best-corrected visual acuity was 0...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28152124/structural-and-functional-recovery-following-limited-iatrogenic-macular-detachment-for-retinal-gene-therapy
#8
Matthew P Simunovic, Kanmin Xue, Jasleen K Jolly, Robert E MacLaren
Importance: The early decline and recovery of retinal structure and function following iatrogenic macular detachment for retinal gene therapy is not well characterized in those with relatively preserved central visual function. Here, the recovery of retinal structure and function over the first month following iatrogenic retinal detachment for the delivery of adeno-associated viral vector encoding Rab Escort Protein 1 is described as a part of gene therapy for choroideremia. Objective: To study changes in both retinal structure and function during the first month following iatrogenic macular detachment surgery...
February 2, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28127734/normal-values-for-microperimetry-with-the-maia-microperimeter-sensitivity-and-fixation-analysis-in-healthy-adults-and-children
#9
Ainhoa Molina-Martín, David P Piñero, Rafael J Pérez-Cambrodí
PURPOSE: To establish normative values of retinal sensitivity and parameters describing the fixation pattern using macular analyzer integrity assessment (MAIA) microperimetry (Centervue, Padova, Italy) in adults and children. METHODS: A sample of 237 eyes of 237 healthy subjects aged between 10 and 70 years (mean age 30.63 ± 16.23 years) was evaluated using the MAIA microperimeter. The following parameters provided by the MAIA device were evaluated: average threshold (AT), macular integrity, fixation indexes (P1% and P2%), bivariate contour ellipse area (BCEA) for 95% and 63% of points, and horizontal (H) and vertical (V) axes of the ellipse of fixation...
January 23, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28033236/longitudinal-microperimetry-evaluation-after-intravitreal-ocriplasmin-injection-for-vitreomacular-traction
#10
Andrea Cacciamani, Aldo Gelso, Joseph M Simonett, Guido Ripandelli, Marco Pileri, Mario Stirpe, Fabio Scarinci
PURPOSE: To determine whether improvements in microperimetry testing are associated with anatomic resolution after ocriplasmin treatment in patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction and relatively preserved baseline best-corrected visual acuity (BCVA). METHODS: Patients with vitreomacular traction received a single 125-μg intravitreal ocriplasmin injection and were followed longitudinally for 6 months with optical coherence tomography, BCVA testing, and microperimetry...
December 28, 2016: Retina
https://www.readbyqxmd.com/read/28009776/bilateral-occipital-pole-hypertensive-stroke-diagnosed-with-macular-integrity-assessment-maia-microperimetry
#11
Sundeep K Kasi, Abtin Shahlaee, Murtaza K Adam, David S Ehmann, Arunan Sivalingam
PURPOSE: To describe the utility of microperimetry testing in the diagnosis of a bilateral occipital stroke. METHODS: Retrospective case report. RESULTS: A 57-year-old male with hypertension presented with complaints of bilateral blurred central vision and bilateral hypertensive retinopathy with cotton-wool spots. Automated perimetry demonstrated a central scotoma in both eyes that did not respect the vertical midline; however, microperimetry testing revealed a bilateral homonymous hemianopia that suggested cerebrovascular disease which was subsequently confirmed with magnetic resonance imaging...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28005720/fundus-autofluorescence-in-rubella-retinopathy-correlation-with-photoreceptor-structure-and-function
#12
Danuta M Bukowska, Sue Ling Wan, Avenell L Chew, Enid Chelva, Ivy Tang, David A Mackey, Fred K Chen
PURPOSE: To illustrate altered fundus autofluorescence in rubella retinopathy and to investigate their relationships with photoreceptor structure and function using multimodal imaging. METHODS: The authors report four cases of rubella retinopathy aged 8, 33, 42, and 50 years. All patients had dilated clinical fundus examination; wide-field color photography; blue, green, and near-infrared autofluorescence imaging and spectral domain optical coherence tomography...
January 2017: Retina
https://www.readbyqxmd.com/read/28005581/retinal-deep-capillary-plexus-ischemia-in-a-case-with-antiphospholipid-syndrome
#13
Serra Arf, Isil Sayman Muslubas, Mumin Hocaoglu, Murat Karacorlu
PURPOSE: To report visualization of a case of retinal deep capillary plexus ischemia with antiphospholipid syndrome. METHODS: A 53-year-old woman was referred with a 1-week history of sudden onset of decreased vision in the right eye. Her symptoms were evaluated by clinical examination, infrared reflectance, fundus autofluorescence, fluorescein angiography, spectral-domain optical coherence tomography, microperimetry, and multifocal electroretinography. RESULTS: The patient's visual acuity on presentation was 0...
September 30, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28002873/effects-of-pupil-dilation-on-maia-microperimetry
#14
Ruofan C Han, Jasleen K Jolly, Kanmin Xue, Robert E MacLaren
BACKGROUND: MAIA microperimetry assesses macular sensitivity to projected point light sources and maps eye movements to assess fixation stability. While microperimetry is gaining prominence as an assessment tool in clinical and research settings, there is no consensus on whether it should be performed before or after pupil dilation. No studies to date have examined the effect of pupil dilation on results. The aim of this project was to elucidate the effect of pupil dilation on microperimetry outcomes...
December 21, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27997459/short-term-findings-on-optical-coherence-tomography-and-microperimetry-in-chronic-central-serous-chorioretinopathy-patients-treated-with-half-dose-photodynamic-therapy
#15
Elon H C van Dijk, Greet Dijkman, Thomas Theelen, Carel B Hoyng, Camiel J F Boon
PURPOSE: To assess the short-term outcome of and possible temporary vision loss after half-dose verteporfin photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC). METHODS: In this prospective study, 14 eyes of 13 cCSC patients who underwent half-dose PDT were included. Patients received spectral-domain optical coherence tomography (OCT) imaging and microperimetry before PDT on the day of treatment and 1 week after treatment...
December 16, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27984509/association-between-parafoveal-capillary-nonperfusion-and-macular-function-in-eyes-with-branch-retinal-vein-occlusion
#16
Saki Manabe, Rie Osaka, Yuki Nakano, Yukari Takasago, Tomoyoshi Fujita, Chieko Shiragami, Kazuyuki Hirooka, Yuki Muraoka, Akitaka Tsujikawa
PURPOSE: To investigate the parafoveal perfusion status of the superficial and deep capillary layer in eyes with resolved branch retinal vein occlusion, and to study its effects on retinal sensitivity. METHODS: In 27 enrolled eyes (27 patients) with resolved branch retinal vein occlusion, superficial and deep capillaries in the macular area (3- × 3-mm, centered on the fovea) were examined with optical coherence tomography angiography. Retinal sensitivity was examined with fundus-monitored microperimetry...
December 10, 2016: Retina
https://www.readbyqxmd.com/read/27983728/safety-and-acceptability-of-an-organic-light-emitting-diode-sleep-mask-as-a-potential-therapy-for-retinal-disease
#17
J N Sahni, G Czanner, T Gutu, S A Taylor, K M Bennett, S M Wuerger, I Grierson, C Murray-Dunning, M N Holland, S P Harding
PurposeThe purpose of the study was to study the effect of an organic light-emitting diode sleep mask on daytime alertness, wellbeing, and retinal structure/function in healthy volunteers and in diabetic macular oedema (DMO).Patients and methodsHealthy volunteers in two groups, 18-30 yrs (A), 50-70 yrs (B) and people with DMO (C) wore masks (504 nm wavelength; 80 cd/m(2) luminance; ≤8 h) nightly for 3 months followed by a 1-month recovery period. Changes from baseline were measured for (means): psychomotor vigilance task (PVT) (number of lapses (NL), response time (RT)), sleep, depression, psychological wellbeing (PW), visual acuity, contrast sensitivity, colour, electrophysiology, microperimetry, and retinal thickness on OCT...
January 2017: Eye
https://www.readbyqxmd.com/read/27959968/enhanced-visualization-of-subtle-outer-retinal-pathology-by-en-face-optical-coherence-tomography-and-correlation-with-multi-modal-imaging
#18
Danuta M Sampson, David Alonso-Caneiro, Avenell L Chew, Tina Lamey, Terri McLaren, John De Roach, Fred K Chen
PURPOSE: To present en face optical coherence tomography (OCT) images generated by graph-search theory algorithm-based custom software and examine correlation with other imaging modalities. METHODS: En face OCT images derived from high density OCT volumetric scans of 3 healthy subjects and 4 patients using a custom algorithm (graph-search theory) and commercial software (Heidelberg Eye Explorer software (Heidelberg Engineering)) were compared and correlated with near infrared reflectance, fundus autofluorescence, adaptive optics flood-illumination ophthalmoscopy (AO-FIO) and microperimetry...
2016: PloS One
https://www.readbyqxmd.com/read/27936154/retinal-morphology-and-sensitivity-are-primarily-impaired-in-eyes-with-neuromyelitis-optica-spectrum-disorder-nmosd
#19
Ryutaro Akiba, Hirotaka Yokouchi, Masahiro Mori, Toshiyuki Oshitari, Takayuki Baba, Setsu Sawai, Satoshi Kuwabara, Shuichi Yamamoto
BACKGROUND: Previous studies of neuromyelitis optica spectrum disorder (NMOSD) using spectral domain optical coherence tomography (SD-OCT) showed that the outer nuclear layer (ONL) in eyes without a history of optic neuritis (ON) was thinner than that of healthy controls. It remains unclear whether the ONL thinning is caused by a direct attack on the retina by an autoantibody or a retrograde degeneration. OBJECTIVE: To determine the mechanisms involved in the retinal damage in eyes with NMOSD without ON...
2016: PloS One
https://www.readbyqxmd.com/read/27935606/structural-and-functional-assessment-of-macula-to-diagnose-glaucoma
#20
H L Rao, R S M Hussain, M Januwada, L N Pillutla, V U Begum, A Chaitanya, S Senthil, C S Garudadri
PurposeTo compare the diagnostic abilities of structural (ganglion cell-inner plexiform layer (GCIPL) thickness measured using spectral domain optical coherence tomography (SDOCT)) and functional (visual sensitivities measured using standard automated perimetry (SAP) and microperimetry (MP)) assessments of macula in glaucoma.MethodsIn a prospective study, 46 control eyes (28 subjects) and 61 glaucoma eyes (46 patients) underwent visual sensitivity estimation at macula (central 10°) by SAP and MP, and GCIPL thickness measurement at macula by SDOCT...
December 9, 2016: Eye
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