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Jonathan Denniss, Andrew T Astle
Purpose: To demonstrate methods that enable visual field sensitivities to be compared with normative data without restriction to a fixed test pattern. Methods: Healthy participants (n = 60, age 19-50) undertook microperimetry (MAIA-2) using 237 spatially dense locations up to 13° eccentricity. Surfaces were fit to the mean, variance, and 5th percentile sensitivities. Goodness-of-fit was assessed by refitting the surfaces 1000 times to the dataset and comparing estimated and measured sensitivities at 50 randomly excluded locations...
October 1, 2016: Investigative Ophthalmology & Visual Science
Stela Vujosevic, Porzia Pucci, Margerita Casciano, Evelyn Longhin, Enrica Convento, Silvia Bini, Edoardo Midena
PURPOSE: To evaluate functional changes (retinal sensitivity and fixation characteristics) determined by microperimetry in patients with early and intermediate AMD over 6 years. METHODS: Prospective, longitudinal follow-up (FU) study of 16 patients (29 eyes) with early and intermediate AMD (AREDS 2 and AREDS 3 classification). All eyes underwent: complete ophthalmic examination with best corrected visual acuity (BCVA) determination, color fundus photo (CFP), optical coherence tomography and microperimetry...
August 31, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Murat Karacorlu, Isil Sayman Muslubas, Mumin Hocaoglu, Hakan Ozdemir, Serra Arf, Omer Uysal
PURPOSE: To evaluate the long-term outcomes of radial optic neurotomy (RON) in patients with optic disk pit maculopathy and to compare the functional and anatomical outcomes of pars plana vitrectomy (PPV) with temporal side single RON versus PPV without RON. METHODS: This retrospective study included 15 eyes of 15 consecutive patients who had surgery for optic disk pit maculopathy. Patients were followed for 12 to 115 months after surgery. Anatomical and functional results were evaluated with optical coherence tomography, MP-1 microperimetry in the central 20°, and measurement of best-corrected visual acuity...
June 14, 2016: Retina
Magdalena Edington, Amun Sachdev, Rupal Morjaria, Victor Chong
BACKGROUND/PURPOSE: Previous studies have shown that patients with diabetic macular edema (DME) with relatively good visual acuity can have slow reading speed. The aim of this study was to evaluate the structural-functional correlation in a cohort of patients with DME and to assess whether the central four retinal points on microperimetry (MP4) could be used as a potentially faster and more reliable method of assessing retinal function in patients with DME than reading speed. METHODS: The study was performed on patients with clinically significant DME...
August 29, 2016: Retina
Vikas Ambiya, Abhilash Goud, Annie Mathai, Padmaja Kumari Rani, Jay Chhablani
PURPOSE: To evaluate the role of navigated yellow microsecond laser in treating subfoveal leaks in nonresolving central serous chorioretinopathy (CSC). METHODS: This prospective study included ten eyes of ten consecutive patients with nonresolving CSC with subfoveal leaks. All eyes were treated with 577 nm navigated yellow microsecond laser (5% duty cycle). Key inclusion criteria include a vision loss for a duration of minimum 3 months duration due to focal subfoveal leak on fluorescein angiography...
2016: Clinical Ophthalmology
Etienne M Schönbach, Hendrik P Scholl
PURPOSE: To demonstrate the usefulness of fundus autofluorescence for diagnosing a subclinical case of Best disease. RESULTS: We describe a 27-year-old white woman without central visual symptoms, visual acuity of 20/12 in both eyes, carrying the previously reported p.Tyr227Cys mutation in the BEST1 gene. Although electrooculography, microperimetry (MP-1), and spectral-domain optical coherence tomography did not reveal unequivocal pathology, fundus autofluorescence imaging allowed to clearly detect a phenotypic correlate of Best disease, namely small areas of significantly increased fundus autofluorescence signals...
August 19, 2016: Retinal Cases & Brief Reports
Ioannis S Dimopoulos, Calvin Tseng, Ian M MacDonald
PURPOSE: To determine test-retest repeatability of microperimetry testing (MP) in choroideremia (CHM) subjects using standard and personalized stimulus grids. METHODS: Fifteen CHM subjects (28 eyes) underwent consecutive repeat examinations with the Macular Integrity Assessment (MAIA) microperimeter using a standard (10°) and a customized macular grid adapted to individual macular pathology. Repeatability of standard-grid mean (MS) and point-wise (PWS) sensitivity was determined and compared with age-matched controls (seven eyes), with PWS separately analyzed for loci within and outside the border of degeneration...
August 1, 2016: Investigative Ophthalmology & Visual Science
Ayako Yasui, Manabu Yamamoto, Kumiko Hirayama, Kunihiko Shiraki, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, Takeya Kohno
PURPOSE: To assess retinal sensitivity after selective retina therapy (SRT) in patients with central serous chorioretinopathy (CSCR). METHODS: Seventeen eyes of 17 patients with CSCR lasting longer than 3 months were treated with SRT (wavelength 527 nm Nd: YLF laser, 50-150 μJ/pulse, spot diameter 200 μm). Measurement of best-corrected visual acuity (BCVA), optical coherence tomography, fluorescence angiography, and microperimetry (MAIA™) were conducted before, and 1 and 3 months after treatment...
August 6, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Shiyuan Wang, Peiquan Zhao
PURPOSE: To describe a peculiar choroidal entity using multimodality imaging and to further understand the relationship between focal choroidal excavation and central serous chorioretinopathy. CASE REPORT: A peculiar entity was detected in both eyes of a 20-year-old male patient who was followed for more than 4 years; one perifoveal focal choroidal excavation and two extrafoveal focal choroidal excavations were noted in each eye. The bilateral perifoveal focal choroidal excavations exhibited progressive development with repeated interconversion between the nonconforming and conforming types...
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Maurizio Battaglia Parodi, Maria Vittoria Cicinelli, Pierluigi Iacono, Gianluigi Bolognesi, Francesco Bandello
PURPOSE: Inherited retinal dystrophies and cone dysfunction syndromes may show a sharp hyporeflective interruption in the outermost retinal layers on optical coherence tomography (OCT), known as foveal cavitation (FC). The aim of the study was to describe the morpho-functional features of FC in patients affected by retinal dystrophies by means of multimodal imaging. METHODS: A consecutive series of patients affected by FC were prospectively recruited for the study...
August 5, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Swetha B Velaga, Muneeswar G Nittala, B Parinitha, S R Sadda, Jay Kumar Chhablani
PURPOSE: To evaluate the correlation between retinal sensitivity and cystoid space characteristics in eyes with diabetic macular edema (DME). MATERIALS AND METHODS: Prospective cross-sectional study of 22 subjects with DME (32 treatment-naïve eyes). All study subjects underwent complete ophthalmic examination, including slit-lamp biomicroscopy and dilated fundus examination. All subjects underwent spectral domain optical coherence tomography (SD-OCT) and microperimetry (MP)...
June 2016: Indian Journal of Ophthalmology
Akiko Fujihara-Mino, Yoshinori Mitamura, Naoki Inomoto, Hiroki Sano, Kei Akaiwa, Kentaro Semba
PURPOSE: To determine the optical coherence tomography (OCT) parameters that are predictive of visual outcome after anti-VEGF therapy for a retinal vein occlusion (RVO). METHODS: Fifty-seven eyes with macular edema (ME) secondary to a central or branch RVO treated with bevacizumab or ranibizumab were studied. Spectral-domain OCT and microperimetry were performed before, 1, 3, and 6 months after the treatment and at the final visit. Central retinal thickness (CRT), macular volume (MV), integrity of the external limiting membrane (ELM), ellipsoid zone (EZ), and foveal bulge (FB), and photoreceptor outer segment (PROS) length were determined...
2016: Clinical Ophthalmology
Hui-Juan Xia, Wei-Jun Wang, Feng'E Chen, Ying Wu, Zhen-Yuan Cai, Wei Chen, Su-Qin Yu, Ying Fan
Objective. To observe the fellow eye in patients undergoing surgery on one eye for treating myopic traction maculopathy. Methods. 99 fellow eyes of consecutive patients who underwent unilateral surgery to treat MTM were retrospectively evaluated. All patients underwent thorough ophthalmologic examinations, including age, gender, duration of follow-up, refraction, axial length, intraocular pressure, lens status, presence/absence of a staphyloma, and best-corrected visual acuity (BCVA). Fundus photographs and SD-OCT images were obtained...
2016: Journal of Ophthalmology
Settimio Rossi, Francesco Testa, Paolo Melillo, Ada Orrico, Michele Della Corte, Francesca Simonelli
BACKGROUND: To evaluate the functional recovery of patients with symptomatic vitreomacular traction (VMT) after Ocriplasmin treatment. METHODS: Prospective, single centre, consecutive case series. Patients were treated with a single intravitreal injection of Ocriplasmin (Jetrea, Thrombogenics Inc, USA, Alcon/Novartis EU). The following outcome measures are considered: resolution of VMT, evaluated through the use of optical coherence tomography (SD-OCT), functional recovery evidenced by multifocal-electroretinogram (mfERG) and microperimetry (MP1) after treatment with Ocriplasmin...
2016: BMC Ophthalmology
Jean-Baptiste Deltour, Pierre Grimbert, Helene Masse, Olivier Lebreton, Michel Weber
INTRODUCTION: The aim of the study was to assess the microperimetric consequences of active internal limiting membrane (ILM) peeling during idiopathic epimacular membrane (IEMM) surgery. MATERIALS AND METHODS: This retrospective monocentric study included 32 eyes of 31 consecutive patients who underwent IEMM surgery. Internal limiting membrane integrity was assessed by ILM Blue staining after IEMM removal: peeling was spontaneous (Group S) or active (Group A). Preprocedure and postprocedure (1 and 6 months) examinations were performed using visual acuity determination, spectral domain optical coherence tomography and microperimetry...
July 14, 2016: Retina
Zhichao Wu, David Cunefare, Elizabeth Chiu, Chi D Luu, Lauren N Ayton, Cynthia A Toth, Sina Farsiu, Robyn H Guymer
PURPOSE: To determine whether longitudinal changes in mesopic visual function on microperimetry occurred independent of its associations with microstructural parameters on spectral-domain optical coherence tomography (SD-OCT) in the early stages of AMD. METHODS: Forty-one AMD eyes underwent microperimetry testing and SD-OCT scans over a 12-month period at 6-month intervals. Microstructural parameters analyzed include the retinal pigment epithelium-drusen complex (RPEDC) layer thickness, number of hyperreflective foci (HF) and their inner retinal migration (represented by a weighted axial distribution score; AxD), and the number of atrophic areas...
July 1, 2016: Investigative Ophthalmology & Visual Science
Paolo Giuseppe Limoli, Celeste Limoli, Enzo Maria Vingolo, Sergio Zaccaria Scalinci, Marcella Nebbioso
BACKGROUND: The aim of this research was to study the overall restoration effect on residual retinal cells through surgically grafted autologous cells onto the surrounding tissue, choroid and retina in order to produce a constant secretion of growth factors (GFs) in dry age-related macular degeneration (AMD) patients. RESULTS: 6 months after surgery, several values were statistically significant in the group with higher RTA. Also patient compliance analysis (PCA) in relation to functional change perception appeared to be very good...
July 6, 2016: Oncotarget
Loredana Arrico, Rossella Giannotti, Manuela Fratipietro, Romualdo Malagola
Purpose. Use of microperimetry (Mp-1), correlating with Humphrey perimetry (30-2 program), in patients affected by primary open-angle glaucoma (POAG) with perimetric defects, in order to obtain an evaluation of the accuracy of the results obtained by Mp-1. Materials and Methods. In this study 40 eyes of 25 patients affected by POAG with perimetric defects were included. All patients underwent microperimetry test by Nidek Mp-1 (NAVIS software version 1.7.2, Nidek Technologies). Mean sensitivity values expressed in decibel (dB) of all tested dots and mean values for each quadrant obtained by microperimetric test were correlated with corresponding quadrants obtained by static perimetry analysis...
2016: Journal of Ophthalmology
Aurélie Calabrèse, Jean-Baptiste Bernard, Géraldine Faure, Louis Hoffart, Eric Castet
PURPOSE: To describe and quantify a largely unnoticed oculomotor pattern that often occurs when patients with central field loss (CFL) read continuous text: Horizontal distribution of eye fixations dramatically varies across sentences and often reveals clusters. Also to statistically analyze the effect of this new factor on reading speed while controlling for the effect of saccadic amplitude (measured in letters per forward saccade, L/FS), an established oculomotor effect. METHODS: Quantification of nonuniformity of eye fixations (NUF factor) was based on statistical analysis of the curvature of fixation distributions...
June 1, 2016: Investigative Ophthalmology & Visual Science
Josh Wallsh, Behnam Sharareh, Ron Gallemore
PURPOSE: To test the efficacy of the intravitreal dexamethasone (DEX) implant in patients with retinal vein occlusions (RVOs) who have failed multiple anti-vascular endothelial growth factor (anti-VEGF) treatments. METHODS: A randomized exploratory study of ten patients with branch RVO or central RVO who received at least two previous anti-VEGF treatments and had persistent or unresponsive cystoid macular edema. Treatment with the DEX implant was either every 4 months or pro re nata (PRN) depending on their group assignment for 1 year...
2016: Clinical Ophthalmology
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