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Microperimetry

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https://www.readbyqxmd.com/read/29124422/perifoveal-interdigitation-zone-loss-in-hydroxychloroquine-toxicity-leads-to-subclinical-bull-s-eye-lesion-appearance-on-near-infrared-reflectance-imaging
#1
Avenell L Chew, Danuta M Sampson, Enid Chelva, Jane C Khan, Fred K Chen
PURPOSE: To characterize the ultrastructural and functional correlates of hydroxychloroquine (HCQ)-induced subclinical bull's eye lesion seen on near-infrared reflectance (NIR) imaging. METHODS: An asymptomatic 54-year-old male taking HCQ presented with paracentral ring-like scotoma, abnormal multifocal electroretinography (mfERG) and preserved ellipsoid zone on optical coherence tomography (OCT). Dense raster OCT was performed to create en face reflectivity maps of the interdigitation zone...
November 9, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29110945/the-progression-of-geographic-atrophy-secondary-to-age-related-macular-degeneration
#2
REVIEW
Monika Fleckenstein, Paul Mitchell, K Bailey Freund, SriniVas Sadda, Frank G Holz, Christopher Brittain, Erin C Henry, Daniela Ferrara
Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) that leads to progressive and irreversible loss of visual function. Geographic atrophy is defined by the presence of sharply demarcated atrophic lesions of the outer retina, resulting from loss of photoreceptors, retinal pigment epithelium (RPE), and underlying choriocapillaris. These lesions typically appear first in the perifoveal macula, initially sparing the foveal center, and over time often expand and coalesce to include the fovea...
October 27, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29084330/characterizing-the-natural-history-of-visual-function-in-choroideremia-using-microperimetry-and-multimodal-retinal-imaging
#3
RANDOMIZED CONTROLLED TRIAL
Jasleen K Jolly, Kanmin Xue, Thomas L Edwards, Markus Groppe, Robert E MacLaren
Purpose: Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field restriction and late central vision loss. The latter marks an acute decline in quality of life but visual prognostication remains challenging. We investigated visual function in CHM by correlating best-corrected visual acuity (BCVA), microperimetry and multimodal imaging. Methods: Fifty-six consecutive CHM patients attending Oxford Eye Hospital were examined with BCVA, 10-2 microperimetry, optical coherence tomography, and fundus autofluorescence (AF)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29060564/detecting-impaired-vision-caused-by-amd-from-gaze-data
#4
Huiying Liu, Yanwu Xu, Damon Wong, Ai Ping Yow, Augustinus Laude, Tock Han Lim
Age Related Macular Degeneration (AMD) is the third leading cause of blindness and the first one in the elderly. AMD usually causes central blindness due to loss of photoreceptor cell . In this paper, we propose to detect AMD caused vision impairment from gaze data. Compared with the current methods, e.g., Amsler grid, Microperimetry and Preferential Hyperacuity Perimetry, to detect vision impairments, the proposed method has several advantages. 1) It does not require the patient to stare at a fixed position throughout the test...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060394/automatic-visual-impairment-detection-system-for-age-related-eye-diseases-through-gaze-analysis
#5
Ai Ping Yow, Damon Wong, Huiying Liu, Hongyuan Zhu, Ivy Jing-Wen Ong, Augustinus Laude, Tock Han Lim
Visual impairment associated with Age-related Macular Degeneration (AMD) often results in a central scotoma which is an alteration in the central vision, leading to distortion or loss of vision. Current methods for assessing visual performance such as Amsler grid and Microperimetry are typically manual and have limitations as an indicator of visual field. In this paper, we present an automated system for detecting visual impairment through gaze tracking (AVIGA). Two types of assessments namely, Impulse Stimuli Response (ISR) test and Pursuit Stimuli Response (PSR) test were implemented in AVIGA system...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057371/dysflective-cones-visual-function-and-cone-reflectivity-in-long-term-follow-up-of-acute-bilateral-foveolitis
#6
Joanna H Tu, Katharina G Foote, Brandon J Lujan, Kavitha Ratnam, Jia Qin, Michael B Gorin, Emmett T Cunningham, William S Tuten, Jacque L Duncan, Austin Roorda
PURPOSE: Confocal adaptive optics scanning laser ophthalmoscope (AOSLO) images provide a sensitive measure of cone structure. However, the relationship between structural findings of diminished cone reflectivity and visual function is unclear. We used fundus-referenced testing to evaluate visual function in regions of apparent cone loss identified using confocal AOSLO images. METHODS: A patient diagnosed with acute bilateral foveolitis had spectral-domain optical coherence tomography (SD-OCT) (Spectralis HRA + OCT system [Heidelberg Engineering, Vista, CA, USA]) images indicating focal loss of the inner segment-outer segment junction band with an intact, but hyper-reflective, external limiting membrane...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29051833/anatomical-and-functional-correlation-in-susac-syndrome-multimodal-imaging-assessment
#7
Alexandre G B Azevedo, Luiz H Lima, Léo Müller, Flávio Rezende Filho, Cláudio Zett, André Maia, Luiz Roisman
BACKGROUND: Susac's syndrome (SuS) is an uncommon disease characterized by retinal microangiopathy that may be assessed more accurately with optical coherence tomography angiography (OCTA), a new imaging technique which provides a retinal microvasculature map. The purpose of this case report is to describe the multimodal imaging findings of SuS correlating OCTA with functional tests. CASE PRESENTATION: Retrospective review of one case with clinical and imaging evidence of SuS...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28991503/current-clinical-application-of-microperimetry-a-review
#8
Ainhoa Molina-Martín, Rafael J Pérez-Cambrodí, David P Piñero
Microperimetry (MP) is a technology that allows the study of retinal sensitivity at different foveal and parafoveal areas as well as eye fixation. It is a technique of functional evaluation, providing a direct correlation between anatomical and functional outcomes. There are a great variety of studies which evaluate the repeatability or reliability of measurements obtained with this technology and also describe and explore different clinical applications. MP has been shown to be useful in the characterization of sensory and motor conditions, such as amblyopia or nystagmus...
October 9, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28973315/correlation-between-macular-integrity-assessment-and-optical-coherence-tomography-imaging-of-ellipsoid-zone-in-macular-telangiectasia-type-2
#9
RANDOMIZED CONTROLLED TRIAL
Dibyendu Mukherjee, Eleonora M Lad, Ryan R Vann, Stephanie J Jaffe, Traci E Clemons, Martin Friedlander, Emily Y Chew, Glenn J Jaffe, Sina Farsiu
Purpose: To correlate ellipsoid zone (EZ) defects on spectral-domain optical coherence tomography (SD-OCT) with retinal sensitivity loss on macular integrity assessment (MAIA) microperimetry in macular telangiectasia type 2 (MacTel). Methods: Macular SD-OCT volumes and microperimetry maps were obtained during the international, multicenter, randomized phase 2 trial of ciliary neurotrophic factor for type 2 MacTel on two visits within 5 days of one another. Software was developed to register SD-OCT to MAIA scanning laser ophthalmoscopy images and to overlay EZ defect areas on the microperimetry maps generated from microperimetry sensitivity values at specific points and from interpolated sensitivity values...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28973313/metrics-and-acquisition-modes-for-fixation-stability-as-a-visual-function-biomarker
#10
MULTICENTER STUDY
Etienne M Schönbach, Mohamed A Ibrahim, Xiangrong Kong, Rupert W Strauss, Beatriz Muñoz, David G Birch, Janet S Sunness, Sheila K West, Hendrik P N Scholl
Purpose: To compare different metrics and acquisition modes of fixation stability as a new visual function biomarker in a large cohort of patients with ABCA4-related Stargardt disease from the multicenter prospective ProgStar study. Methods: Fixation was tested during a separate fixation exam and also dynamically during a sensitivity exam, using fundus-tracking microperimetry (Nidek MP-1). Fixation data were analyzed using the bivariate contour ellipse area (BCEA), the 2/4 degree method, and the Fujii classification...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28951388/retinal-microperimetry-a-new-tool-for-identifying-type-2-diabetic-patients-at-risk-of-developing-alzheimer%C3%A2-s-disease
#11
Andreea Ciudin, Olga Simó-Servat, Cristina Hernández, Gabriel Arcos, Susana Diego, Ángela Sanabria, Óscar Sotolongo, Isabel Hernández, Mercè Boada, Rafael Simó
Type 2 diabetes is associated with a high risk of cognitive impairment and dementia. Therefore, strategies aimed at identifying those patients at risk of dementia are needed. Given that the retina is a brain-derived tissue it may provide a non-invasive way of examining brain pathology. The aims of the study were to evaluate whether retinal sensitivity: 1) Correlates with the specific parameters of brain imaging related to cognitive impairment; 2) Discriminates diabetic patients with mild cognitive impairment (MCI) from those with normal cognition and Alzheimer's disease (AD)...
September 26, 2017: Diabetes
https://www.readbyqxmd.com/read/28940374/the-effect-of-prism-on-preferred-retinal-locus
#12
David Lewerenz, Daniel Blanco, Chase Ratzlaff, Ashley Zodrow
BACKGROUND: Whether prism, especially base-up prism, affects the area of the retina used for fixation in a patient with central scotoma has been a controversial subject for 35 years. Our pilot study employed microperimetry to evaluate the effect of base-up prism on the fixation locus, or preferred retinal locus (PRL), in subjects with central scotoma. METHODS: We used a microperimeter to assess the PRL in 13 visually impaired subjects with central scotoma under four conditions: no lens, a lens with no prism (control lens), 6(Δ) base-up, and 10(Δ) base-up...
September 20, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28902720/evaluation-of-the-macula-prior-to-cataract-surgery
#13
Marta McKeague, Priya Sharma, Allen C Ho
PURPOSE OF REVIEW: To describe recent evidence regarding methods of evaluation of retinal structure and function prior to cataract surgery. RECENT FINDINGS: Studies in patients with cataract but no clinically detectable retinal disease have shown that routine use of optical coherence tomography (OCT) prior to cataract surgery can detect subtle macular disease, which may alter the course of treatment or lead to modification of consent. The routine use of OCT has been especially useful in patients being considered for advanced-technology intraocular lenses (IOLs) as subtle macular disease can be a contraindication to the use of these lenses...
September 11, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28892948/microperimetry-a-new-tool-for-assessing-retinal-sensitivity-in-macular-diseases
#14
Memota Laishram, Krishnagopal Srikanth, A R Rajalakshmi, Swathi Nagarajan, G Ezhumalai
INTRODUCTION: Macular disease is the leading cause of low vision in the Western world. Drusen and pigmentary irregularities are common among the rural Northern Indian population. The disease process leads to loss of central vision, metamorphopsia, macropsia or micropsia and colour vision defect. AIM: To study the retinal sensitivity changes in macular diseases using microperimetry. MATERIALS AND METHODS: It was an observational study, conducted in the Department of Ophthalmology at a rural tertiary care hospital...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28836011/retinal-sensitivity-after-displacement-of-submacular-hemorrhage-due-to-polypoidal-choroidal-vasculopathy-effectiveness-and-safety-of-subretinal-tissue-plasminogen-activator
#15
Shuhei Kimura, Yuki Morizane, Ryo Matoba, Mio Hosokawa, Yusuke Shiode, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Kosuke Takahashi, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga
PURPOSE: To investigate the effectiveness of displacement of submacular hemorrhage (SMH) caused by polypoidal choroidal vasculopathy (PCV) by assessing retinal sensitivity using microperimetry. METHODS: We retrospectively reviewed the medical records of 11 consecutive PCV patients with SMH. All patients underwent vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-air exchange, followed by antivascular endothelial growth factor therapy using a pro re nata regimen...
November 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28831303/pseudoamblyopia-in-congenital-cyclotropia
#16
Antonio Frattolillo, Filippo Tassi, Valentina Di Croce, Costantino Schiavi
PURPOSE: To study the effect of surgery on amblyopia and suppression associated with congenital cyclovertical strabismus. METHODS: The fixation pattern was investigated with microperimetry before and soon after surgery in ten consecutive children operated for congenital superior oblique palsy at the S. Martino Hospital, Belluno, Italy, between September 2014 and December 2015. Changes in visual performance in terms of best-corrected visual acuity (BCVA) and stereopsis between the day before and one week after surgery were also evaluated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28820183/technique-of-retinal-gene-therapy-delivery-of-viral-vector-into-the-subretinal-space
#17
K Xue, M Groppe, A P Salvetti, R E MacLaren
PurposeSafe and reproducible delivery of gene therapy vector into the subretinal space is essential for successful targeting of the retinal pigment epithelium (RPE) and photoreceptors. The success of surgery is critical for the clinical efficacy of retinal gene therapy. Iatrogenic detachment of the degenerate (often adherent) retina in patients with hereditary retinal degenerations and small volume (eg, 0.1 ml) subretinal injections pose new surgical challenges.MethodsOur subretinal gene therapy technique involved pre-operative planning with optical coherence tomography (OCT) and autofluorescence (AF) imaging, 23 G pars plana vitrectomy, internal limiting membrane staining with Membrane Blue Dual (DORC BV, Zuidland, Netherlands), a two-step subretinal injection using a 41 G Teflon tipped cannula (DORC) first with normal saline to create a parafoveal bleb followed by slow infusion of viral vector via the same self-sealing retinotomy...
September 2017: Eye
https://www.readbyqxmd.com/read/28810041/morphologic-and-postoperative-fixation-characteristics-of-the-macular-epiretinal-membrane-in-young-patients-undergoing-surgery
#18
Tian Tian, Chunli Chen, Haiying Jin, Qi Zhang, Yu Xu, Shiyuan Wang, Xiang Zhang, Peiquan Zhao
BACKGROUND AND OBJECTIVE: To describe morphologic characteristics, surgical outcomes, postoperative preferred retinal loci (PRL), and fixation stability of epiretinal membranes (ERMs) in young patients. PATIENTS AND METHODS: This retrospective study analyzed 43 eyes of 41 young patients (age range: 0.8 years to 28 years) with ERMs, which were divided into two groups: secondary ERMs (SERMs; n = 28) and idiopathic ERMs (IERMs; n = 13). All 43 eyes underwent 25-gauge vitrectomy and membrane peeling...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28800019/the-natural-history-of-full-field-stimulus-threshold-decline-in-choroideremia
#19
Ioannis S Dimopoulos, Paul R Freund, Jacob A Knowles, Ian M MacDonald
PURPOSE: To evaluate full-field sensitivity thresholds (FSTs) across a wide range of choroideremia (CHM) disease stages and to determine their applicability as functional endpoints for CHM clinical trials. METHODS: Thirty CHM subjects (60 eyes) and 50 healthy controls (50 eyes) underwent FST testing under dark-adapted conditions to determine rod- and cone-mediated FSTs. Central retinal structure and function were assessed using fundus autofluorescence and microperimetry...
August 9, 2017: Retina
https://www.readbyqxmd.com/read/28753983/outcome-of-full-thickness-macular-hole-surgery-in-choroideremia
#20
Mays Talib, Leonoor S Koetsier, Robert E MacLaren, Camiel J F Boon
The development of a macular hole is relatively common in retinal dystrophies eligible for gene therapy such as choroideremia. However, the subretinal delivery of gene therapy requires an uninterrupted retina to allow dispersion of the viral vector. A macular hole may thus hinder effective gene therapy. Little is known about the outcome of macular hole surgery and its possible beneficial and/or adverse effects on retinal function in patients with choroideremia. We describe a case of a unilateral full-thickness macular hole (FTMH) in a 45year-old choroideremia patient (c...
July 21, 2017: Genes
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