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https://www.readbyqxmd.com/read/29456631/a-model-of-anterior-cruciate-ligament-injury-in-cynomolgus-monkeys-developed-via-arthroscopic-surgery
#1
Lei Zhang, Taiyuan Guan, Ji Qi, Shaoqun Zhang, Xin Zhou, Yang Liu, Shijie Fu
The anterior cruciate ligament (ACL) is an important structure that maintains the stability of knee joints. Animal models of ACL injury are helpful to explore its underlying mechanisms, and strategies for prevention, treatment and rehabilitation. Therefore, the aim of the present study was to develop an efficient model of ACL injury in cynomolgus monkeys via arthroscopic techniques. In the present study, 18 cynomolgus monkeys were randomly divided into a model group (n=6), a sham operation group (n=6) and a blank control group (n=6)...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29454799/identification-of-genomic-variants-causing-sperm-abnormalities-and-reduced-male-fertility
#2
REVIEW
Jeremy F Taylor, Robert D Schnabel, Peter Sutovsky
Whole genome sequencing has identified millions of bovine genetic variants; however, there is currently little understanding about which variants affect male fertility. It is imperative that we begin to link detrimental genetic variants to sperm phenotypes via the analysis of semen samples and measurement of fertility for bulls with alternate genotypes. Artificial insemination (AI) bulls provide a useful model system because of extensive fertility records, measured as sire conception rates (SCR). Genetic variants with moderate to large effects on fertility can be identified by sequencing the genomes of fertile and subfertile or infertile sires identified with high or low SCR as adult AI bulls or yearling bulls that failed Breeding Soundness Evaluation...
February 10, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29453603/repeatable-and-reproducible-measurements-of-myocardial-oxidative-metabolism-blood-flow-and-external-efficiency-using-11-c-acetate-pet
#3
Kai Yi Wu, Vincent Dinculescu, Jennifer M Renaud, Shin-Yee Chen, Ian G Burwash, Lisa M Mielniczuk, Rob S B Beanlands, Robert A deKemp
BACKGROUND: Non-invasive approaches to investigate myocardial efficiency can help track the progression of heart failure (HF). This study evaluates the repeatability and reproducibility of 11 C-acetate positron emission tomography (PET) imaging of oxidative metabolism. METHODS AND RESULTS: Dynamic 11 C-acetate PET scans were performed at baseline and followup (47 ± 22 days apart) in 20 patients with stable HF with reduced ejection fraction. Two observers blinded to patients' clinical data used FlowQuant ® to evaluate test-retest repeatability, as well as intra- and inter-observer reproducibility of 11 C-acetate tracer uptake and clearance rates, for the measurement of myocardial oxygen consumption (MVO 2 ), myocardial external efficiency (MEE), work metabolic index (WMI), and myocardial blood flow...
February 16, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29453169/randomized-eeg-functional-brain-networks-in-major-depressive-disorders-with-greater-resilience-and-lower-rich-club-coefficient
#4
Minghui Zhang, Haiyan Zhou, Liqing Liu, Lei Feng, Jie Yang, Gang Wang, Ning Zhong
OBJECTIVE: Some studies have shown that the functional electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) networks in those with major depressive disorders (MDDs) have an abnormal random topology. In this study we aimed to further investigate the characteristics of the randomized functional brain networks in MDDs by examining resting-state scalp-EEG data. METHODS: Based on the methods of independent component analysis (ICA) and graph theoretic analysis, the abnormalities in the power spectral density (PSD) functional brain networks were compared between 13 MDDs and 13 matched healthy controls (HCs)...
January 31, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29452866/intrapatient-study-comparing-3d-printed-bolus-versus-standard-vinyl-gel-sheet-bolus-for-postmastectomy-chest-wall-radiation-therapy
#5
James L Robar, Kathryn Moran, James Allan, James Clancey, Tami Joseph, Krista Chytyk-Praznik, R Lee MacDonald, John Lincoln, Parisa Sadeghi, Robert Rutledge
PURPOSE: This patient study evaluated the use of 3-dimensional (3D) printed bolus for chest wall radiation therapy compared with standard sheet bolus with regard to accuracy of fit, surface dose measured in vivo, and efficiency of patient setup. By alternating bolus type over the course of therapy, each patient served as her own control. METHODS AND MATERIALS: For 16 patients undergoing chest wall radiation therapy, a custom 5.0 mm thick bolus was designed based on the treatment planning computed tomography scan and 3D printed using polylactic acid...
December 24, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29451292/multifunctional-luminescent-magnetic-cryocooler-in-a-gd-5-mn-2-pyramidal-complex
#6
Wei Huang, Shuaidan Huang, Ming Zhang, Yancong Chen, Gui-Lin Zhuang, Yao Li, Ming-Liang Tong, Juan Yong, Yujie Li, Dayu Wu
Magnetic cooling is a highly efficient refrigeration technique with the potential of replacing expensive and rare helium-3 in the field of ultra-low temperature cooling. However, the visualization of a cryogen at an extremely low temperature and in a strong magnetic field is challenging, but it is crucial for the precise positioning and in situ thermal probe measurements in potential practical applications. Here, the activation of a red-emissive Mn(ii) ion using 3d/4f chemistry produces a luminescent molecule cooler, [Gd 5 Mn 2 (L OMe ) 2 (OH) 4 (Ac) 6 (MeOH) 10 Cl 2 ]Cl 3 ·2MeOH (1), with the core of an Mn(ii)-anchored heptanuclear [GdMn] pyramid...
February 16, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29449761/active-localization-and-tracking-of-needle-and-target-in-robotic-image-guided-intervention-systems
#7
Mark Renfrew, Mark Griswold, M Cenk Çavuşoğlu
This paper describes a framework of algorithms for the active localization and tracking of flexible needles and targets during image-guided percutaneous interventions. The needle and target configurations are tracked by Bayesian filters employing models of the needle and target motions and measurements of the current system state obtained from an intra-operative imaging system which is controlled by an entropy-minimizing active localization algorithm. Versions of the system were built using particle and unscented Kalman filters and their performance was measured using both simulations and hardware experiments with real magnetic resonance imaging data of needle insertions into gel phantoms...
January 2018: Autonomous Robots
https://www.readbyqxmd.com/read/29449144/a-dynamic-graph-cuts-method-with-integrated-multiple-feature-maps-for-segmenting-kidneys-in-2d-ultrasound-images
#8
Qiang Zheng, Steven Warner, Gregory Tasian, Yong Fan
RATIONALE AND OBJECTIVES: Automatic segmentation of kidneys in ultrasound (US) images remains a challenging task because of high speckle noise, low contrast, and large appearance variations of kidneys in US images. Because texture features may improve the US image segmentation performance, we propose a novel graph cuts method to segment kidney in US images by integrating image intensity information and texture feature maps. MATERIALS AND METHODS: We develop a new graph cuts-based method to segment kidney US images by integrating original image intensity information and texture feature maps extracted using Gabor filters...
February 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29449073/healthy-minds-0-100-years-optimising-the-use-of-european-brain-imaging-cohorts-lifebrain
#9
Kristine B Walhovd, Anders M Fjell, René Westerhausen, Lars Nyberg, Klaus P Ebmeier, Ulman Lindenberger, David Bartrés-Faz, William F C Baaré, Hartwig R Siebner, Richard Henson, Christian A Drevon, Gun Peggy Strømstad Knudsen, Isabelle Budin Ljøsne, Brenda W J H Penninx, Paolo Ghisletta, Ole Rogeberg, Lorraine Tyler, Lars Bertram
The main objective of "Lifebrain" is to identify the determinants of brain, cognitive and mental (BCM) health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the life span, we will merge fine-grained BCM health measures of more than 5000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive and mental health measures for the broader cohorts, exceeding 27,000 examinations in total...
February 12, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29446756/plasmon-enhanced-scattering-and-charge-transfer-in-few-layer-graphene-interacting-with-buried-printed-2d-pattern-of-silver-nanoparticles
#10
Robert Carles, Maxime Bayle, Caroline Bonafos
Hybrid structures combing silver nanoparticles and few-layer graphene have been synthetized by combining low-energy ion beam synthesis and stencil techniques. A single plane of metallic nanoparticles plays the role of an embedded plasmonic enhancer located in dedicated areas at a controlled nanometer distance from deposited graphene layers. Optical imaging, reflectance and Raman scattering mapping are used to measure the enhancement of electronic and vibrational properties of these layers. In particular electronic Raman scattering is shown as notably efficient to analyze the optical transfer of charge carriers between the systems and the presence of intrinsic and extrinsic defects...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29445234/tuning-the-optical-properties-of-silicon-quantum-dots-via-surface-functionalization-with-conjugated-aromatic-fluorophores
#11
Mohammed Abdelhameed, Diego Rota Martir, Shalimar Chen, William Z Xu, Olabode O Oyeneye, Subrata Chakrabarti, Eli Zysman-Colman, Paul A Charpentier
Silicon Quantum Dots (SQDs) have recently attracted great interest due to their excellent optical properties, low cytotoxicity, and ease of surface modification. The size of SQDs and type of ligand on their surface has a great influence on their optical properties which is still poorly understood. Here we report the synthesis and spectroscopic studies of three families of unreported SQDs functionalized by covalently linking to the aromatic fluorophores, 9-vinylphenanthrene, 1-vinylpyrene, and 3-vinylperylene...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445111/fluvastatin-protects-cochleae-from-damage-by-high-level-noise
#12
Claus-Peter Richter, Hunter Young, Sonja V Richter, Virginia Smith-Bronstein, Stuart R Stock, Xianghui Xiao, Carmen Soriano, Donna S Whitlon
Exposure to noise and ototoxic drugs are responsible for much of the debilitating hearing loss experienced by about 350 million people worldwide. Beyond hearing aids and cochlear implants, there have been no other FDA approved drug interventions established in the clinic that would either protect or reverse the effects of hearing loss. Using Auditory Brainstem Responses (ABR) in a guinea pig model, we demonstrate that fluvastatin, an inhibitor of HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway, protects against loss of cochlear function initiated by high intensity noise...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444552/optometry-facilitated-teleophthalmology-an-audit-of-the-first-year-in-western-australia
#13
Stephen E Bartnik, Stephen P Copeland, Angela J Aicken, Angus W Turner
BACKGROUND: Lions Outback Vision has run a state-wide teleophthalmology service since 2011. In September 2015 the Australian federal government introduced a Medicare reimbursement for optometry-facilitated teleophthalmology consultations under specific circumstances. This audit demonstrates the first 12 months experience with this scheme. We aim to provide practical insights for others looking to embed a telemedicine program as part of delivering outreach clinical services. METHODS: A 12-month retrospective audit was performed between September 2015 and August 2016, inclusive...
February 14, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29444410/enhanced-ion-transmission-efficiency-up-to-m-z-24-000-for-maldi-protein-imaging-mass-spectrometry
#14
Boone M Prentice, Daniel Ryan, Raf Van de Plas, Richard M Caprioli, Jeffrey M Spraggins
The molecular identification of species of interest is an important part of an imaging mass spectrometry (IMS) experiment. The high resolution accurate mass capabilities of Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) have recently been shown to facilitate the identification of proteins in matrix-assisted laser desorption/ionization (MALDI) IMS. However, these experiments are typically limited to proteins giving rise to ions of relatively low m/z due to difficulties transmitting and measuring large molecular weight ions of low charge states...
February 14, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29438421/a-parallel-spatiotemporal-saliency-and-discriminative-online-learning-method-for-visual-target-tracking-in-aerial-videos
#15
Amirhossein Aghamohammadi, Mei Choo Ang, Elankovan A Sundararajan, Ng Kok Weng, Marzieh Mogharrebi, Seyed Yashar Banihashem
Visual tracking in aerial videos is a challenging task in computer vision and remote sensing technologies due to appearance variation difficulties. Appearance variations are caused by camera and target motion, low resolution noisy images, scale changes, and pose variations. Various approaches have been proposed to deal with appearance variation difficulties in aerial videos, and amongst these methods, the spatiotemporal saliency detection approach reported promising results in the context of moving target detection...
2018: PloS One
https://www.readbyqxmd.com/read/29435706/detail-enhanced-multimodality-medical-image-fusion-based-on-gradient-minimization-smoothing-filter-and-shearing-filter
#16
Xingbin Liu, Wenbo Mei, Huiqian Du
In this paper, a detail-enhanced multimodality medical image fusion algorithm is proposed by using proposed multi-scale joint decomposition framework (MJDF) and shearing filter (SF). The MJDF constructed with gradient minimization smoothing filter (GMSF) and Gaussian low-pass filter (GLF) is used to decompose source images into low-pass layers, edge layers, and detail layers at multiple scales. In order to highlight the detail information in the fused image, the edge layer and the detail layer in each scale are weighted combined into a detail-enhanced layer...
February 13, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29434565/semi-automated-analysis-of-diaphragmatic-motion-with-dynamic-magnetic-resonance-imaging-in-healthy-controls-and-non-ambulant-subjects-with-duchenne-muscular-dystrophy
#17
Courtney A Bishop, Valeria Ricotti, Christopher D J Sinclair, Matthew R B Evans, Jordan W Butler, Jasper M Morrow, Michael G Hanna, Paul M Matthews, Tarek A Yousry, Francesco Muntoni, John S Thornton, Rexford D Newbould, Robert L Janiczek
Subjects with Duchenne Muscular Dystrophy (DMD) suffer from progressive muscle damage leading to diaphragmatic weakness that ultimately requires ventilation. Emerging treatments have generated interest in better characterizing the natural history of respiratory impairment in DMD and responses to therapy. Dynamic (cine) Magnetic Resonance Imaging (MRI) may provide a more sensitive measure of diaphragm function in DMD than the commonly used spirometry. This study presents an analysis pipeline for measuring parameters of diaphragmatic motion from dynamic MRI and its application to investigate MRI measures of respiratory function in both healthy controls and non-ambulant DMD boys...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29434257/broadband-imaging-with-one-planar-diffractive-lens
#18
Nabil Mohammad, Monjurul Meem, Bing Shen, Peng Wang, Rajesh Menon
We demonstrate imaging over the visible band using a single planar diffractive lens. This is enabled via multi-level diffractive optics that is designed to focus over a broad wavelength range, which we refer to as an achromatic diffractive lens (ADL). We designed, fabricated and characterized two ADLs with numerical apertures of 0.05 and 0.18. Diffraction-limited focusing is demonstrated for the NA = 0.05 lens with measured focusing efficiency of over 40% across the entire visible spectrum (450 nm to 750 nm)...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29430923/interactive-visual-exploration-of-3d-mass-spectrometry-imaging-data-using-hierarchical-stochastic-neighbor-embedding-reveals-spatio-molecular-structures-at-full-data-resolution
#19
Walid M Abdelmoula, Nicola Pezzotti, Thomas Hölt, Jouke Dijkstra, Anna Vilanova, Liam A McDonnell, Boudewijn P F Lelieveldt
Technological advances in mass spectrometry imaging (MSI) have contributed to the growing interest in 3D-MSI. However, the large size of 3D-MSI datasets has made their efficient analysis, visualization and the identification of informative molecular patterns, computationally challenging. Hierarchical stochastic neighbor embedding (HSNE), a non-linear dimensionality reduction technique that aims at finding hierarchical and multi-scale representations of large datasets, is a recent development that enables the analysis of millions of data points, with manageable time and memory complexities...
February 12, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29430166/riemannian-nonlinear-mixed-effects-models-analyzing-longitudinal-deformations-in-neuroimaging
#20
Hyunwoo J Kim, Nagesh Adluru, Heemanshu Suri, Baba C Vemuri, Sterling C Johnson, Vikas Singh
Statistical machine learning models that operate on manifold-valued data are being extensively studied in vision, motivated by applications in activity recognition, feature tracking and medical imaging. While non-parametric methods have been relatively well studied in the literature, efficient formulations for parametric models (which may offer benefits in small sample size regimes) have only emerged recently. So far, manifold-valued regression models (such as geodesic regression) are restricted to the analysis of cross-sectional data, i...
July 2017: Proceedings
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