Lia M Pinto, Alexandros Pailas, Max Bondarchenko, Abhishek Bharadwaj Sharma, Katrin Neumann, Anthony J Rizzo, Céline Jeanty, Nathalie Nicot, Carine Racca, Mindy K Graham, Catherine Naughton, Yaqun Liu, Chun-Long Chen, Paul J Meakin, Nick Gilbert, Sébastien Britton, Alan K Meeker, Christopher M Heaphy, Florence Larminat, Eric Van Dyck
Maintaining chromatin integrity at the repetitive non-coding DNA sequences underlying centromeres is crucial to prevent replicative stress, DNA breaks and genomic instability. The concerted action of transcriptional repressors, chromatin remodelling complexes and epigenetic factors controls transcription and chromatin structure in these regions. The histone chaperone complex ATRX/DAXX is involved in the establishment and maintenance of centromeric chromatin through the deposition of the histone variant H3.3...
December 1, 2023: Nucleic Acids Research