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Nunzia Zanotta, Giuseppina Campisciano, Federica Scrimin, Ura Blendi, Annalisa Marcuzzi, Ezio Vincenti, Sergio Crovella, Manola Comar
OBJECTIVE: The vulvar pain syndrome (VPS) is a multifactorial disease severely influencing the lifestyle of affected women. Among possible etiological factors, local injury, peripheral and/or central sensitization of the nervous system, and a chronic inflammatory status have been positively associated with the development of VPS. The identification of a constitutive altered local inflammatory profile in VPS women may represent an important point in the characterization of patients' phenotype as a useful marker influencing the vulvar micro-environment...
May 24, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Gerda Trutnovsky, Christina Plieseis, Vesna Bjelic-Radisic, Marie-Christine BertholinyGalvez, Karl Tamussino, Daniela Ulrich
INTRODUCTION: Vulvodynia and chronic pelvic pain are common but underdiagnosed chronic gynecologic pain syndromes. Insufficient knowledge regarding prevalence, typical pain patterns and associated factors contribute to delayed diagnosis. The present study explored the symptoms and characteristics of women presenting with vulvodynia and/or chronic pelvic pain to a gynecologic outpatient clinic. MATERIALS AND METHODS: Electronic charts of women diagnosed with vulvodynia and/or chronic pelvic pain between January 2010 and December 2015 were reviewed...
May 31, 2018: Journal of Psychosomatic Obstetrics and Gynaecology
James Sorensen, Katherine E Bautista, Georgine Lamvu, Jessica Feranec
Dyspareunia and vulvodynia are genital pain disorders that have devastating effects on women's quality of life. These disorders occur with high prevalence and place a significant financial burden on women and the health care system. Many women do not report genital pain, and most providers do not inquire about this type of pain. As a result, women also experience social isolation. Numerous treatments are thought to improve quality of life and decrease pain; however, more studies are needed. This review aims to provide an overview of clinical evaluation methods and to summarize treatment options for women suffering from dyspareunia and vulvodynia...
March 27, 2018: Curēus
Candace S Brown, Gloria A Bachmann, Jim Wan, David C Foster
OBJECTIVE: To evaluate whether extended-release gabapentin is more effective than placebo among women with vulvodynia. METHODS: In a multicenter double-blind, placebo-controlled randomized crossover trial, gabapentin (1,200-3,000 mg/d) was compared with a placebo. The primary outcome was mean pain intensity (0, no pain at all to 10, worst pain ever) on the tampon test (a standardized tampon insertion and removal test used as a surrogate marker for dyspareunia) during the last 7 days of the maintenance phase...
June 2018: Obstetrics and Gynecology
Kelly B Smith, Rosemary Basson, Leslie A Sadownik, Jordanna Isaacson, Lori A Brotto
OBJECTIVE: To examine maternity providers' recommendations for pregnant women with vulvodynia regarding management of vulvar pain and postpartum care, and to examine if, and how, a woman's chronic vulvar pain affects providers' examination and management during labour. METHODS: This research was part of a larger study that invited physicians and midwives to answer a questionnaire regarding pregnancy and childbirth care in women with vulvodynia. To achieve the current objectives, the questionnaire included both dichotomous (yes or no) and open-ended items...
May 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Marius Alexandru Moga, Oana Gabriela Dimienescu, Andreea Bălan, Ioan Scârneciu, Barna Barabaș, Liana Pleș
Botulinum toxins (BoNTs) are produced by several anaerobic species of the genus Clostridium and, although they were originally considered lethal toxins, today they find their usefulness in the treatment of a wide range of pathologies in various medical specialties. Botulinum neurotoxin has been identified in seven different isoforms (BoNT-A, BoNT-B, BoNT-C, BoNT-D, BoNT-E, BoNT-F, and BoNT-G). Neurotoxigenic Clostridia can produce more than 40 different BoNT subtypes and, recently, a new BoNT serotype (BoNT-X) has been reported in some studies...
April 21, 2018: Toxins
Judith M Schlaeger, Nobuari Takakura, Hiroyoshi Yajima, Miho Takayama, Alana D Steffen, Elizabeth M Gabzdyl, Robyn A Nisi, Kathleen McGowan Gruber, Jason M Bussell, Diana J Wilkie
Background: Efficacy of acupuncture is difficult to demonstrate without a feasible double-blind milieu. Double-blind acupuncture needles have been validated in single session protocols with one or two needles but not been tested in a protocol requiring many needles and repeated sessions. Methods: We determined the feasibility of a 13-needle, 10-session study protocol. Feasibility focused on (1) enrolling and retaining participants; (2) two acupuncturists accurately implementing a double-blind, multi-needle, multi-session protocol; (3) participants completing measures; and (4) protocol acceptability to participants...
2018: Pilot and Feasibility Studies
Rufina Kim, Kerri-Lynn Kelly, Merle Olsen, J Curtis Nickel
INTRODUCTION: We report our early clinical observations on the use of topical meloxicam and lidocaine gel for patients with vulvodynia. METHODS: This is an early experience in participants with a history of vulvodynia evaluated and treated at the Queen's University Pelvic and Bladder Pain Clinic. Combination meloxicam 0.3% and lidocaine 5% were provided to the participants and they were instructed to apply 5 cc to the vulvar area twice daily. Standardized assessment was conducted for each participant before the start of the topical therapy and again at one week included Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), and pain scoring (Likert) for vulvar pain, in addition to a subjective global assessment after a week of treatment...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Robyn A Jackowich, Leah Pink, Allan Gordon, Évéline Poirier, Caroline F Pukall
BACKGROUND: Persistent genital arousal disorder (PGAD) is an understudied condition characterized by unwanted physiologic genital arousal in the absence of subjective sexual arousal. Markos and Dinsmore (Int J STD AIDS 2013;24:852-858) theorized that PGAD shares a number of similarities with vulvodynia (unexplained chronic vulvar pain [CVP]), including symptom characteristics and comorbidities. AIM: To compare medical histories, symptom characteristics, pain characteristics, and daily functioning among women with persistent genital pain (PGA) (n = 42), painful PGA (n = 37), and CVP (n = 42) symptoms...
April 2018: Journal of Sexual Medicine
S S Witkin
No abstract text is available yet for this article.
March 31, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Barbara D Reed, Melissa A Plegue, Ananda Sen, Hope K Haefner, Javed Siddiqui, Daniel G Remick
OBJECTIVE: The aim of the study was to assess the association between cytokines/neurokines after in vitro stimulation with Candida antigen or lipopolysaccharide (LPS) in blood samples among women with and without vulvodynia. MATERIALS AND METHODS: Women with vulvodynia and asymptomatic controls at three offices at the University of Michigan were examined clinically and completed a comprehensive survey in this cross-sectional study. Cytokine/neurokine levels were determined on blood samples using established ELISA protocols...
April 2018: Journal of Lower Genital Tract Disease
G Miranda Varella Pereira, M Soriano Marcolino, Z Silveira Nogueira Reis, M Vale de Castro Monteiro
BACKGROUND: Vulvodynia is the most common type of chronic pelvic pain and dyspareunia in premenopausal women. The effect of drugs for the treatment of vulvodynia remains poorly discussed. OBJECTIVES: To conduct a systematic review of randomised controlled studies which assess medications used to treat vulvar pain in vulvodynia. SEARCH STRATEGY: Web of Science, Cochrane Library, EBSCO Academic, LILACS and MEDLINE were searched from 1985 to September 2016...
March 23, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Natalie O Rosen, Amy Muise, Emily A Impett, Isabelle Delisle, Mary Lou Baxter, Sophie Bergeron
Background: Vulvodynia is an idiopathic vulvovaginal pain condition that has significant sexual and relational consequences. Most women with vulvodynia continue to have intercourse, possibly because of a desire to approach positive outcomes (e.g., intimacy) and avoid negative outcomes (e.g., partner disappointment). Purpose: This study examined daily associations between approach and avoidance sexual goals and women's pain during intercourse and couples' sexual and relational well-being, as well as the mediating role of sexual cues...
February 17, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Justine Benoit-Piau, Sophie Bergeron, Audrey Brassard, Chantale Dumoulin, Samir Khalifé, Guy Waddell, Mélanie Morin
OBJECTIVE: To investigate the association between fear-avoidance variables, pelvic floor muscle (PFM) function and pain intensity in women with provoked vestibulodynia (PVD) as well as the moderator effect of partner support. METHODS: A total of 173 women diagnosed with PVD participated in the study. Fear-avoidance variables were evaluated with validated self-administered questionnaires: pain catastrophizing (Pain Catastrophizing Scale), pain-related fear (Pain Anxiety Symptoms Scale), and partner support (Partner Support Questionnaire)...
March 9, 2018: Clinical Journal of Pain
Amy Muise, Sophie Bergeron, Emily A Impett, Isabelle Delisle, Natalie O Rosen
OBJECTIVE: To examine the role of a novel motivational perspective-sexual communal motivation-in women's pain during intercourse and both partners' distress in couples coping with vulvodynia, a prevalent gynecological pain condition. Our goal was to test whether sexual communal strength (i.e., motivation to meet a partner's sexual needs) and unmitigated sexual communion (i.e., prioritization of a partner's sexual needs in neglect of one's own needs) were indirectly associated with pain, depression, and anxiety via sexual distress...
March 2018: Journal of Psychosomatic Research
Annie Chen, Elise De, Charles Argoff
Objective: To demonstrate the prevalence of small fiber polyneuropathy (SFPN) in patients with refractory chronic pelvic pain (CPP). Design: Retrospective study of prospective database. Subjects: Participants were complex CPP patients recruited from subspecity referral clinics defined as those who were refractory to initial treatment and/or exhibited comorbid pain syndromes at initial presentation. Methods: Comprehensive treatment history for CPP was obtained, and participants referred as above; 3-mm punch biopsies were obtained of the lower extremity and sent to diagnostic reference labs to evaluate for SFPN...
February 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Isabella M Fuentes, Julie A Christianson
Pain is the most reported and troublesome symptom of nearly all functional disorders affecting the genitourinary and gastrointestinal organs. Patients with irritable bowel syndrome (IBS), interstitial cystitis/painful bladder syndrome (IC/PBS), vulvodynia, and/or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS; collectively termed chronic pelvic pain syndromes) report pain severe enough to impact quality of life and often suffer from symptoms of or are diagnosed with more than one of these syndromes...
2018: Frontiers in Systems Neuroscience
James M Weinberger, Justin Houman, Ashley T Caron, Jennifer Anger
BACKGROUND: Female sexual dysfunction (FSD) is a highly prevalent condition. Nevertheless, the scientific literature has only recently begun to accumulate evidence for treatment modalities that address the underlying etiologies of FSD. AIM: The purpose of this systematic review is to elucidate what treatments are effective across the various symptom complexes of FSD. METHODS: Utilizing Meta-analysis of Observational Studies in Epidemiology guidelines, we conducted a systematic review of PubMed, EMBASE, clinicaltrials...
February 3, 2018: Sexual Medicine Reviews
Peter Leusink, Doreth Teunissen, Peter L Lucassen, Ellen T Laan, Antoine L Lagro-Janssen
BACKGROUND: The gap between the relatively high prevalence of provoked vulvodynia (PVD) in the general population and the low incidence in primary care can partly be explained by physicians' lack of knowledge about the assessment and management of PVD. OBJECTIVES: To recognize barriers and facilitators of GPs in the diagnostic process of women presenting with recurrent vulvovaginal complaints. METHODS: A qualitative focus group study in 17 Dutch GPs, five men and 12 women...
December 2018: European Journal of General Practice
Myriam Pâquet, Natalie O Rosen, Marc Steben, Marie-Hélène Mayrand, Marie Santerre-Baillargeon, Sophie Bergeron
Vulvodynia is a idiopathic vulvovaginal pain condition that interferes with the sexual and mental health of affected couples. Research has underscored that psychological factors, such as anxiety and depression, are associated with its development and maintenance and related sexual impairment. However, the daily role of anxiety and depressive symptoms in the pain and sexuality outcomes of couples coping with vulvodynia is not well understood. Using a dyadic daily experience method, 127 women (mean age = 26...
January 5, 2018: Journal of Pain: Official Journal of the American Pain Society
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