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Vulvodynia

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https://www.readbyqxmd.com/read/29629863/early-experience-with-topical-meloxicam-and-lidocaine-combination-for-the-treatment-of-vulvodynia
#1
Rufina Kim, Kerri-Lynn Kelly, Merle Olsen, J Curtis Nickel
INTRODUCTION: We report our early clinical observations on the use of topical meloxicam and lidocaine gel for patients with vulvodynia. METHODS: This is an early experience in participants with a history of vulvodynia evaluated and treated at the Queen's University Pelvic and Bladder Pain Clinic. Combination meloxicam 0.3% and lidocaine 5% were provided to the participants and they were instructed to apply 5 cc to the vulvar area twice daily. Standardized assessment was conducted for each participant before the start of the topical therapy and again at one week included Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), and pain scoring (Likert) for vulvar pain, in addition to a subjective global assessment after a week of treatment...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29609914/an-online-cross-sectional-comparison-of-women-with-symptoms-of-persistent-genital-arousal-painful-persistent-genital-arousal-and-chronic-vulvar-pain
#2
Robyn A Jackowich, Leah Pink, Allan Gordon, Évéline Poirier, Caroline F Pukall
BACKGROUND: Persistent genital arousal disorder (PGAD) is an understudied condition characterized by unwanted physiologic genital arousal in the absence of subjective sexual arousal. Markos and Dinsmore (Int J STD AIDS 2013;24:852-858) theorized that PGAD shares a number of similarities with vulvodynia (unexplained chronic vulvar pain [CVP]), including symptom characteristics and comorbidities. AIM: To compare medical histories, symptom characteristics, pain characteristics, and daily functioning among women with persistent genital pain (PGA) (n = 42), painful PGA (n = 37), and CVP (n = 42) symptoms...
April 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29603845/vulvodynia-drug-research-heterogeneity-in-uncertainty-out
#3
Steven S Witkin
Vulvodynia is defined as an inability to experience pain-free vaginal penetration. It is a clinical diagnosis based on the exclusion of causative dermatological, infectious or endocrine factors. In the absence of objective laboratory criteria it is inevitable that multiple etiologies will be present in women with this diagnosis. It has been proposed that vulvodynia may be due to excessive local inflammation, sensitivity to a prior or current infection or dietary components, elevated local nerve fibre proliferation, hormonal alterations, central pain anomalies, pelvic floor muscle dysfunction, genetic factors or past psychological trauma (Lev-Sagie A and Witkin SS...
March 31, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29570566/nerve-growth-factor-and-selected-cytokines-in-women-with-and-without-vulvodynia
#4
Barbara D Reed, Melissa A Plegue, Ananda Sen, Hope K Haefner, Javed Siddiqui, Daniel G Remick
OBJECTIVE: The aim of the study was to assess the association between cytokines/neurokines after in vitro stimulation with Candida antigen or lipopolysaccharide (LPS) in blood samples among women with and without vulvodynia. MATERIALS AND METHODS: Women with vulvodynia and asymptomatic controls at three offices at the University of Michigan were examined clinically and completed a comprehensive survey in this cross-sectional study. Cytokine/neurokine levels were determined on blood samples using established ELISA protocols...
April 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29569822/a-systematic-review-of-drug-treatment-of-vulvodynia-evidence-of-a-strong-placebo-effect
#5
Glaucia Miranda Varella Pereira, Milena Soriano Marcolino, Zilma Silveira Nogueira Reis, Marilene Vale de Castro Monteiro
BACKGROUND: Vulvodynia is the most common type of chronic pelvic pain and dyspareunia in premenopausal women. The effect of drugs for the treatment of vulvodynia remains poorly discussed. OBJECTIVES: To conduct a systematic review of randomised controlled studies which assess medications used to treat vulvar pain in vulvodynia. SEARCH STRATEGY: Web of Science, Cochrane Library, EBSCO Academic, LILACS and MEDLINE were searched from 1985 to September 2016...
March 23, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29538663/sexual-cues-mediate-the-daily-associations-between-interpersonal-goals-pain-and-well-being-in-couples-coping-with-vulvodynia
#6
Natalie O Rosen, Amy Muise, Emily A Impett, Isabelle Delisle, Mary Lou Baxter, Sophie Bergeron
Background: Vulvodynia is an idiopathic vulvovaginal pain condition that has significant sexual and relational consequences. Most women with vulvodynia continue to have intercourse, possibly because of a desire to approach positive outcomes (e.g., intimacy) and avoid negative outcomes (e.g., partner disappointment). Purpose: This study examined daily associations between approach and avoidance sexual goals and women's pain during intercourse and couples' sexual and relational well-being, as well as the mediating role of sexual cues...
February 17, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29528864/fear-avoidance-and-pelvic-floor-muscle-function-are-associated-with-pain-intensity-in-women-with-vulvodynia
#7
Justine Benoit-Piau, Sophie Bergeron, Audrey Brassard, Chantale Dumoulin, Samir Khalifé, Guy Waddell, Mélanie Morin
OBJECTIVE: To investigate the association between fear-avoidance variables, pelvic floor muscle (PFM) function and pain intensity in women with provoked vestibulodynia (PVD) as well as the moderator effect of partner support. METHODS: A total of 173 women diagnosed with PVD participated in the study. Fear-avoidance variables were evaluated with validated self-administered questionnaires: pain catastrophizing (Pain Catastrophizing Scale), pain-related fear (Pain Anxiety Symptoms Scale), and partner support (Partner Support Questionnaire)...
March 9, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29455897/communal-motivation-in-couples-coping-with-vulvodynia-sexual-distress-mediates-associations-with-pain-depression-and-anxiety
#8
Amy Muise, Sophie Bergeron, Emily A Impett, Isabelle Delisle, Natalie O Rosen
OBJECTIVE: To examine the role of a novel motivational perspective-sexual communal motivation-in women's pain during intercourse and both partners' distress in couples coping with vulvodynia, a prevalent gynecological pain condition. Our goal was to test whether sexual communal strength (i.e., motivation to meet a partner's sexual needs) and unmitigated sexual communion (i.e., prioritization of a partner's sexual needs in neglect of one's own needs) were indirectly associated with pain, depression, and anxiety via sexual distress...
March 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29447372/small-fiber-polyneuropathy-is-prevalent-in-patients-experiencing-complex-chronic-pelvic-pain
#9
Annie Chen, Elise De, Charles Argoff
Objective: To demonstrate the prevalence of small fiber polyneuropathy (SFPN) in patients with refractory chronic pelvic pain (CPP). Design: Retrospective study of prospective database. Subjects: Participants were complex CPP patients recruited from subspecity referral clinics defined as those who were refractory to initial treatment and/or exhibited comorbid pain syndromes at initial presentation. Methods: Comprehensive treatment history for CPP was obtained, and participants referred as above; 3-mm punch biopsies were obtained of the lower extremity and sent to diagnostic reference labs to evaluate for SFPN...
February 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29434541/the-influence-of-early-life-experience-on-visceral-pain
#10
REVIEW
Isabella M Fuentes, Julie A Christianson
Pain is the most reported and troublesome symptom of nearly all functional disorders affecting the genitourinary and gastrointestinal organs. Patients with irritable bowel syndrome (IBS), interstitial cystitis/painful bladder syndrome (IC/PBS), vulvodynia, and/or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS; collectively termed chronic pelvic pain syndromes) report pain severe enough to impact quality of life and often suffer from symptoms of or are diagnosed with more than one of these syndromes...
2018: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29402732/female-sexual-dysfunction-a-systematic-review-of-outcomes-across-various-treatment-modalities
#11
REVIEW
James M Weinberger, Justin Houman, Ashley T Caron, Jennifer Anger
BACKGROUND: Female sexual dysfunction (FSD) is a highly prevalent condition. Nevertheless, the scientific literature has only recently begun to accumulate evidence for treatment modalities that address the underlying etiologies of FSD. AIM: The purpose of this systematic review is to elucidate what treatments are effective across the various symptom complexes of FSD. METHODS: Utilizing Meta-analysis of Observational Studies in Epidemiology guidelines, we conducted a systematic review of PubMed, EMBASE, clinicaltrials...
February 3, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29359605/facilitators-and-barriers-in-the-diagnostic-process-of-vulvovaginal-complaints-vulvodynia-in-general-practice-a-qualitative-study
#12
Peter Leusink, Doreth Teunissen, Peter L Lucassen, Ellen T Laan, Antoine L Lagro-Janssen
BACKGROUND: The gap between the relatively high prevalence of provoked vulvodynia (PVD) in the general population and the low incidence in primary care can partly be explained by physicians' lack of knowledge about the assessment and management of PVD. OBJECTIVES: To recognize barriers and facilitators of GPs in the diagnostic process of women presenting with recurrent vulvovaginal complaints. METHODS: A qualitative focus group study in 17 Dutch GPs, five men and 12 women...
December 2018: European Journal of General Practice
https://www.readbyqxmd.com/read/29309891/daily-anxiety-and-depressive-symptoms-in-couples-coping-with-vulvodynia-associations-with-women-s-pain-women-s-sexual-function-and-both-partners-sexual-distress
#13
Myriam Pâquet, Natalie O Rosen, Marc Steben, Marie-Hélène Mayrand, Marie Santerre-Baillargeon, Sophie Bergeron
Vulvodynia is a idiopathic vulvovaginal pain condition that interferes with the sexual and mental health of affected couples. Research has underscored that psychological factors, such as anxiety and depression, are associated with its development and maintenance and related sexual impairment. However, the daily role of anxiety and depressive symptoms in the pain and sexuality outcomes of couples coping with vulvodynia is not well understood. Using a dyadic daily experience method, 127 women (mean age = 26...
January 5, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29290220/diagnosis-and-management-of-vulvodynia-in-postmenopausal-women
#14
REVIEW
Pedro Vieira-Baptista, Gilbert Donders, Lynnette Margesson, Libby Edwards, Hope K Haefner, Faustino R Pérez-López
Vulvodynia, defined as vulvar pain or burning sensation for more than 3 months, without an identifiable cause, can occur at any age. In this paper, the authors address the classification, epidemiology, etiology, diagnosis, and treatment of this condition, focusing on postmenopausal women. In postmenopausal women, vulvar pain and dyspareunia can often be attributed to low levels of estrogen resulting in vulvovaginal atrophy. While correction of vulvovaginal atrophy is an important part of the management of these patients, it will usually be insufficient to manage vulvodynia...
February 2018: Maturitas
https://www.readbyqxmd.com/read/29289972/vulvodynia-and-depression-a-case-study
#15
Aneta Gerhant, Ewelina Anna Dziwota, Aneta Perzyńska-Starkiewicz, Magdalena Derewianka-Polak, Marcin Olajossy
The analysis of the case of vulvodynia coexisting with depression. Remission in terms of pain and affective symptoms was achieved simultaneously after including gabapentin in the treatment at a dose of 900 mg/d. Depressive disorders may constitute a risk factor for vulvodynia and occur as a secondary condition to pain. The frequency of other functional pain syndromes such as fibromyalgia and temporomandibular syndrome is much higher in patients with vulvodynia than in the overall female population. The risk of suicide in vulvodynia, similarly to other chronic pain syndromes, is relatively high, especially with coexisting depressive symptoms...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29202395/generalized-unprovoked-vulvodynia-a-retrospective-study-on-the-efficacy-of-treatment-with-amitriptyline-gabapentin-or-pregabalin
#16
Heleen J van Beekhuizen, Jessica Oost, Willem I van der Meijden
OBJECTIVE: To describe patient characteristics of women diagnosed with generalized unprovoked vulvodynia (GUV) and to estimate efficacy and tolerability of treatment. MATERIAL AND METHODS: Retrospective observational study in 241 women who presented with GUV at three vulvar disease clinics in Rotterdam, The Netherlands during 1996-2013. Main outcome was efficacy of amitriptyline, gabapentin or pregabalin treatment. RESULTS: The median duration of symptoms was 24 months and median age 62 years (range 36-89)...
January 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29198513/the-vulvar-pain-assessment-questionnaire-factor-structure-preliminary-norms-internal-consistency-and-test-retest-reliability
#17
Emma Dargie, Ronald R Holden, Caroline F Pukall
BACKGROUND: The Vulvar Pain Assessment Questionnaire (VPAQ) was developed to assist in the assessment and diagnosis of chronic vulvar pain (vulvodynia). AIM: To further establish the psychometric properties of the VPAQ by examining factor structure, test-retest reliability, internal consistency, and scale normative data, and to gather feedback from those with vulvar pain about the usefulness and accessibility of the questionnaire. METHODS: 182 participants completed a confidential online study and 70 participated again at time 2 (4 weeks later)...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29106051/treatment-of-chronic-refractory-neuropathic-pelvic-pain-with-high-frequency-10-kilohertz-spinal-cord-stimulation
#18
Thomas Simopoulos, Robert J Yong, Jatinder S Gill
Chronic neuropathic pelvic pain remains a recalcitrant problem in the field of pain management. Case series on application of 10 kHz spinal cord stimulation is presented. High frequency stimulation can improve chronic neuropathic pain states that are known to be mediated at the conus medullaris and offers another avenue for the treatment of these patients.
November 6, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29070953/vulvodynia-a-consideration-of-clinical-and-methodological-research-challenges-and-recommended-solutions
#19
REVIEW
Serena Corsini-Munt, Kate M Rancourt, Justin P Dubé, Meghan A Rossi, Natalie O Rosen
Vulvodynia, an idiopathic chronic vulvar pain, is a prevalent genital pain condition that results in significant impairment to sexual, relational, and psychological functioning of affected women and their romantic partners. Despite its high prevalence, there remain gaps in knowledge and health care access for women coping with vulvodynia, given its varied clinical presentation and no widely accepted treatment protocol. The past several decades have seen important advancements in understanding vulvodynia and developing effective treatments; however, progress has been impeded due to clinical and methodological challenges in conducting research with this vulnerable population...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28964711/a-comparison-of-approach-and-avoidance-sexual-goals-in-couples-with-vulvodynia-and-community-controls
#20
Justin P Dubé, Sophie Bergeron, Amy Muise, Emily A Impett, Natalie O Rosen
BACKGROUND: Provoked vestibulodynia (PVD) is a prevalent form of vulvodynia that interferes with the sexual and relational functioning of affected couples. Approach and avoidance sexual goals are associated with the sexual and relationship well-being of women with PVD and their partners. However, whether sexual goals differ in couples coping with PVD compared with community couples is unknown. AIMS: To compare the approach and avoidance sexual goals of women with PVD and their partners with a control sample of community women and their partners to build on an established motivational model and to compare the sexual goals of women with PVD with those of their partners...
September 27, 2017: Journal of Sexual Medicine
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