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https://www.readbyqxmd.com/read/28735523/histochemistry-and-immunolocalisation-of-glucokinin-in-antidiabetic-plants-used-in-traditional-mexican-medicine
#1
Guillermo Laguna-Hernández, Carlos A Rio-Zamorano, Itzel G Meneses-Ochoa, Alicia E Brechú-Franco
Mexico is a megadiverse country that has 3,600 to 4,000 species of medicinal plants, of which approximately 800 are used to treat conditions related to diabetes mellitus (DM). DM is a chronic degenerative disease of energy metabolism that exists as two types: type 1 (DM1) and type 2 (DM2). DM is considered a public health problem that affects 7% of the Mexican population older than 20 years. DM is clinically controlled with hypoglycaemic drugs, alpha-glucosidase inhibitors, insulin secretion stimulants or the direct application of insulin...
June 21, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28735508/initiating-insulin-how-to-help-people-with-type-2-diabetes-start-and-continue-insulin-successfully
#2
William H Polonsky, Joyce Arsenault, Lawrence Fisher, Pamela Kushner, Eden M Miller, Teresa L Pearson, Mariusz Tracz, Stewart Harris, Norbert Hermanns, Bernd-M Scholz, Robyn K Pollom, Magaly Perez-Nieves, Roy Daniel Pollom, Irene Hadjiyianni
No abstract text is available yet for this article.
July 23, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28735467/outcomes-of-preexisting-diabetes-mellitus-in-breast-colorectal-and-prostate-cancer
#3
Robert I Griffiths, José M Valderas, Emily C McFadden, Clare R Bankhead, Bernadette A Lavery, Nada F Khan, Richard J Stevens, Nancy L Keating
PURPOSE: Preexisting diabetes is associated with increased morbidity and mortality in cancer. We examined the impact of incident cancer on the long-term outcomes of diabetes. METHODS: Using the United Kingdom Clinical Practice Research Datalink, we identified three cohorts of diabetes patients subsequently diagnosed with breast, colorectal, or prostate cancer, each matched to diabetic noncancer controls. Patients were required to have survived at least 1 year after cancer diagnosis (cases) or a matched index date (controls), and were followed up to 10 years for incident microvascular and macrovascular complications and mortality...
July 22, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28735459/diabetes-and-the-hospitalized-patient-a-cluster-analytic-framework-for-characterizing-the-role-of-sex-race-and-comorbidity-from-2006-to-2011
#4
Nisha Nataraj, Julie Simmons Ivy, Fay Cobb Payton, Joseph Norman
In the US, one in four adults has two or more chronic conditions; this population accounts for two thirds of healthcare spending. Comorbidity, the presence of multiple simultaneous health conditions in an individual, is increasing in prevalence and has been shown to impact patient outcomes negatively. Comorbidities associated with diabetes are correlated with increased incidence of preventable hospitalizations, longer lengths of stay (LOS), and higher costs. This study focuses on sex and race disparities in outcomes for hospitalized adult patients with and without diabetes...
July 22, 2017: Health Care Management Science
https://www.readbyqxmd.com/read/28735376/the-socio-economic-impact-of-bariatric-surgery
#5
Arendse Tange Larsen, Betina Højgaard, Rikke Ibsen, Jakob Kjellberg
INTRODUCTION: A recurring argument for bariatric surgery is cost savings due to sustained weight loss and reductions in comorbidities. However, studies prompting this argument tend to focus only on health care costs, and in some of them, cost changes after surgery have been modelled. The aim of this study was to generate real-world evidence on the socio-economic impact of bariatric surgery, by evaluating the effect on both direct and indirect costs. MATERIALS AND METHODS: Using real-world data from national registries, predictions of health care costs, social transfer payments and income were performed for a surgically treated individual and compared to those for a similar but non-surgically treated individual 3 years before and after surgery...
July 22, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28735354/transplantation-sites-for-human-and-murine-islets
#6
Rebecca A Stokes, Kim Cheng, Amit Lalwani, Michael M Swarbrick, Helen E Thomas, Thomas Loudovaris, Tom W Kay, Wayne J Hawthorne, Philip J O'Connell, Jenny E Gunton
AIMS/HYPOTHESIS: Beta cell replacement is a potential cure for type 1 diabetes. In humans, islet transplants are currently infused into the liver via the portal vein, although this site has disadvantages. Here, we investigated alternative transplantation sites for human and murine islets in recipient mice, comparing the portal vein with quadriceps muscle and kidney, liver and spleen capsules. METHODS: Murine islets were isolated from C57BL6/J mice and transplanted into syngeneic recipients...
July 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/28735342/cataract-in-the-chronically-exposed-residents-of-the-techa-riverside-villages
#7
L D Mikryukova, A V Akleyev
The present study is based on a retrospective analysis of archive data of the Clinical Department of the Urals Research Center for Radiation Medicine that has been established to examine and treat accidentally exposed residents of the Urals Region. All individuals included in this study were examined by an ophthalmologist. The study of cataract incidence has been conducted retrospectively for the period from 1951 till 2000 among chronically exposed residents of the Techa riverside villages (6343 persons). Individual accumulated absorbed doses to soft tissues (analogue of eye dose) reached 1...
July 22, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28735279/value-of-screening-for-and-treating-pre-diabetes-is-reduced-by-low-test-accuracy-and-indirect-evidence-of-impact-on-patient-important-outcomes
#8
Neri A Alvarez-Villalobos, Rene Rodriguez-Gutierrez, Victor M Montori
No abstract text is available yet for this article.
July 22, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28735214/indazole-based-ligands-for-estrogen-related-receptor-%C3%AE-as-potential-anti-diabetic-agents
#9
Raymond J Patch, Hui Huang, Sharmila Patel, Wing Cheung, Guozhang Xu, Bao-Ping Zhao, Derek A Beauchamp, Dionisios Rentzeperis, John G Geisler, Hossein B Askari, Jianying Liu, Jyotsna Kasturi, Meghan Towers, Micheal D Gaul, Mark R Player
Estrogen-related receptor α (ERRα) is an orphan nuclear receptor that has been functionally implicated in the regulation of energy homeostasis. Herein is described the development of indazole-based N-alkylthiazolidenediones, which function in biochemical assays as selective inverse agonists against this receptor. Series optimization provided several potent analogues that inhibited the recruitment of a co-activator peptide fragment in vitro (IC50s < 50 nM) and reduced fasted circulating insulin and triglyceride levels in a sub-chronic pre-diabetic rat model when administered orally (10 mg/kg)...
July 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28735151/do-air-pollution-and-neighborhood-greenness-exposures-improve-the-predicted-cardiovascular-risk
#10
Maayan Yitshak-Sade, Itai Kloog, Victor Novack
BACKGROUND: Numerous studies show associations between exposure to Particulate Matter and Cardiovascular disease (CVD). Current cardiovascular equations incorporate the major risk factors for CVD. The patients' environment, however, is not incorporated in these equations. METHODS: In a retrospective analysis, we assessed the contribution of neighborhood greenness and particulate matter (coarse-PM and PM<2.5μm-PM2.5) to the development of CVD by analyzing the change in prediction abilities...
July 20, 2017: Environment International
https://www.readbyqxmd.com/read/28735142/bifurcation-location-and-growth-of-aneurysm-size-are-significantly-associated-with-an-irregular-shape-of-unruptured-intracranial-aneurysms
#11
Xin Feng, Baorui Zhang, Erkang Guo, Luyao Wang, Zenguhi Qian, Peng Liu, Xiaolong Wen, Wenjuan Xu, Chuhan Jiang, Youxiang Li, Zhongxue Wu, Aihua Liu
BACKGROUND AND OBJECTIVE: Previous studies firmly proved that an irregular aneurysmal shape was strongly associated with intracranial aneurysm (IA) rupture, but it is unclear how irregularly shaped intracranial aneurysms (IAs) form. We aimed to identify the factors related to irregular shape of IAs. METHOD: We retrospectively analyzed of consecutive patients evaluated or treated for IA at our institution from June 2015 to July 2016. According to the imaging morphology of aneurysm, the enrolled patients are divided into irregular and regular group...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735097/protecting-the-heart-through-mk2-modulation-toward-a-role-in-diabetic-cardiomyopathy-and-lipid-metabolism
#12
REVIEW
Matthieu Ruiz, Lise Coderre, Bruce Gordon Allen, Christine Des Rosiers
Various signaling pathways have been identified in the heart as important players during development, physiological adaptation or pathological processes. This includes the MAPK families, particularly p38MAPK, which is involved in several key cellular processes, including differentiation, proliferation, apoptosis, inflammation, metabolism and survival. Disrupted p38MAPK signaling has been associated with several diseases, including cardiovascular diseases (CVD) as well as diabetes and its related complications...
July 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28735064/associations-of-fibroblast-growth-factor-21-with-cardiovascular-risk-and-%C3%AE-cell-function-in-patients-who-had-no-history-of-diabetes
#13
Jun-Sing Wang, Wayne Huey-Herng Sheu, Wen-Jane Lee, I-Te Lee, Shih-Yi Lin, Wen-Lieng Lee, Kae-Woei Liang, Shing-Jong Lin
BACKGROUND: We investigated the associations of fibroblast growth factor 21 (FGF-21) with cardiovascular risk and β-cell function in patients who had no history of diabetes. METHODS: We enrolled 269 outpatients who had been referred for an oral glucose tolerance test (OGTT). Plasma glucose, insulin, and FGF-21 were measured before and at 2h after the OGTT. β-cell function was assessed using the insulinogenic index, corrected for insulin resistance. Patients' 10-year coronary heart disease (CHD) risk was assessed using the Chinese Multi-provincial Cohort Study functions...
July 19, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28735032/a-prospective-study-of-breastfeeding-intentions-of-healthy-weight-and-overweight-women-as-predictors-of-breastfeeding-outcomes
#14
Susan J de Jersey, Kimberley Mallan, Justine Forster, Lynne A Daniels
OBJECTIVE: Women with a higher BMI are at increased risk of breastfeeding for a shorter duration, however it is unclear if weight status itself or other factors such as feeding intentions are responsible for early breastfeeding cessation. The aim of this study was determine the influence of maternal pre-pregnancy weight status on infant feeding intentions during pregnancy using a validated scale and assess whether high intentions to exclusively breastfeed measured during pregnancy predicted feeding mode at discharge and at 4 months postpartum in both healthy weight (Hwt) (BMI< 25kg/m(2)) and overweight (Owt)(BMI > 25kg/m(2)) women...
July 5, 2017: Midwifery
https://www.readbyqxmd.com/read/28734987/bioavailable-and-free-25-hydroxyvitamin-d-and-vitamin-d-binding-protein-in-polycystic-ovary-syndrome-relationships-with-obesity-and-insulin-resistance
#15
Negar Naderpoor, Soulmaz Shorakae, Sally K Abell, Aya Mousa, Anju E Joham, Lisa J Moran, Nigel K Stepto, Poli Mara Spritzer, Helena J Teede, Barbora de Courten
Polycystic ovary syndrome (PCOS) is a common condition characterised by both reproductive and metabolic features (obesity, insulin resistance, diabetes risk). Some evidence suggests that women with PCOS have lower vitamin D levels compared to healthy controls. Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues. To our knowledge, no previous studies have examined DBP, bioavailable and free 25-hydroxyvitamin D (25(OH)D) in women with PCOS...
July 19, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28734952/potential-predictive-role-of-lipid-peroxidation-markers-for-type-2-diabetes-in-the-tunisian-population
#16
Houda Bouhajja, Faten Hadj Kacem, Rania Abdelhedi, Marwa Ncir, Jordan D Dimitrov, Rim Marrakchi, Kamel Jamoussi, Ahmed Rebai, Abdelfattah El Feki, Mohamed Abid, Hammadi Ayadi, Srini V Kaveri, Mouna Mnif-Feki, Noura Bougacha-Elleuch
OBJECTIVES: We evaluated the potential clinical relevance of malondialdehyde (MDA) and autoantibodies to copper oxidized low-density lipoprotein (CuOx-LDL) in type 2 diabetes occurrence. METHODS: This cross-sectional study enrolled 69 normoglycemic subjects, 18 prediabetic patients and 108 type 2 diabetes patients. MDA concentration was assessed spectrophotometrically. Plasma IgG, IgA and IgM levels to CuOx-LDL were determined by ELISA. RESULTS: Plasma MDA levels were considerably higher in obese, prediabetic and type 2 diabetes subjects compared to controls...
July 19, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28734951/emergency-department-management-of-diabetic-ketoacidosis-and-hyperosmolar-hyperglycemic-state-national-survey-of-attitudes-and-practice
#17
Alexandra L Hamelin, Justin W Yan, Ian G Stiell
OBJECTIVES: In 2013, the Association, now Diabetes Canada, published national clinical practice guidelines for the effective management of diabetic ketoacidosis and hyperosmolar hyperglycemic states in adults. We sought to determine emergency physician compliance rates and attitudes toward these guidelines and to identify potential barriers to their use in Canadian emergency departments. METHODS: An online survey consisting of questions related to the awareness and use of the Canadian Diabetes Association 2013 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada was distributed to 500 randomly selected members of the Canadian Association of Emergency Physicians...
July 19, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28734946/impaired-rhodopsin-generation-in-the-rat-model-of-diabetic-retinopathy
#18
Volha V Malechka, Gennadiy Moiseyev, Yusuke Takahashi, Younghwa Shin, Jian-Xing Ma
Diabetic retinopathy is a common complication of diabetes mellitus. Diabetic patients experience functional deficits in dark adaptation, contrast sensitivity, and color perception before microvascular pathologies become apparent. Here, we evaluated early changes in neural retinal function and in retinoid metabolism in the eye in diabetes. Streptozotocin-induced diabetic rats showed decreased a-wave and b-wave amplitudes of scotopic and photopic electroretinography responses four months after diabetes induction compared to nondiabetic controls...
July 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28734926/derivation-and-evaluation-of-age-specific-multivariate-reference-regions-to-aid-in-identification-of-abnormal-filling-patterns-the-hunt-and-vamis-studies
#19
Jonas Selmeryd, Egil Henriksen, Håvard Dalen, Pär Hedberg
OBJECTIVES: This study aimed to derive age-specific multivariate reference regions (MVRs) able to classify subjects into those having normal or abnormal filling patterns and to evaluate the prognostic impact of this classification. BACKGROUND: The integration of several parameters is necessary to diagnose disorders of left ventricular (LV) filling because no single measurement accurately describes the complexity of diastolic function. However, no generally accepted validated multiparametric algorithm currently exists...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734906/results-from-15years-of-quality-surveillance-for-a-national-indigenous-point-of-care-testing-program-for-diabetes
#20
Mark Shephard, Anne Shephard, Bridgit McAteer, Tamika Regnier, Kristina Barancek
INTRODUCTION: Diabetes is a major health problem for Australia's Aboriginal and Torres Strait Islander peoples. Point-of-care testing for haemoglobin A1c (HbA1c) has been the cornerstone of a long-standing program (QAAMS) to manage glycaemic control in Indigenous people with diabetes and recently, to diagnose diabetes. METHODS: The QAAMS quality management framework includes monthly testing of quality control (QC) and external quality assurance (EQA) samples. Key performance indicators of quality include imprecision (coefficient of variation [CV%]) and percentage acceptable results...
July 19, 2017: Clinical Biochemistry
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