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https://www.readbyqxmd.com/read/28922257/endoscopic-and-histological-assessment-of-paediatric-inflammatory-bowel-disease-over-a-three-year-follow-up-period
#1
J J Ashton, Q Bonduelle, E Mossotto, T Coelho, A Batra, N A Afzal, B Vadgama, S Ennis, R M Beattie
OBJECTIVES: Discrepancies between Inflammatory bowel disease (IBD) endoscopic/histological extent are documented at diagnosis. It is unclear whether these differences persist through disease course, with potential impact on categorisation and management. We aimed to analyse the progression of disease over a 3-year period. METHODS: Patients aged < 17 years, diagnosed between 2010-2013 at Southampton Children's Hospital and followed-up for 3 years were eligible...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28877085/current-health-status-and-medical-therapy-of-patients-with-pediatric-onset-inflammatory-bowel-disease-a-survey-based-analysis-on-1280-patients-aged-10-25-years-focusing-on-differences-by-age-of-onset
#2
Antje Timmer, Renee Stark, Jenny Peplies, Martin Classen, Martin W Laass, Sibylle Koletzko
OBJECTIVE: There are inconsistent reports on age-related differences in inflammatory bowel disease (IBD). On the basis of patient information, we describe the clinical presentation and therapy in relation to age at diagnosis in longstanding pediatric IBD. PATIENTS AND METHODS: Two surveys were conducted in children and young adults (age: 10-25 years) by pretested postal questionnaires. The main analyses are descriptive, showing proportions and distributions per grouped age of diagnosis...
September 4, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28863076/histologic-correlates-of-clinical-and-endoscopic-severity-in-children-newly-diagnosed-with-ulcerative-colitis
#3
Brendan Boyle, Margaret H Collins, Zhu Wang, David Mack, Anne Griffiths, Cary Sauer, James Markowitz, Neal LeLeiko, David Keljo, Joel Rosh, Susan S Baker, Marian Pfefferkorn, Melvin Heyman, Ashish Patel, Robert Baldassano, Joshua Noe, Paul Rufo, Subra Kugathasan, Thomas Walters, Lee Denson, Jeffrey Hyams
To characterize rectal histology in an inception cohort of children newly diagnosed with ulcerative colitis (UC) and to explore its relationship with clinical indices of disease severity. The PROTECT (Predicting Response to Standardized Pediatric Colitis Therapy) Study enrolled children 17 years of age and younger newly diagnosed with UC. Baseline rectal biopsies were evaluated for acute and chronic inflammation, eosinophilic inflammation (peak eosinophil count > 32 eosinophils/high powered field, eosinophilic cryptitis or abscesses), and architectural/nonarchitectural chronic changes...
August 31, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28859138/inflammatory-bowel-disease-and-patterns-of-volatile-organic-compounds-in-the-exhaled-breath-of-children-a-case-control-study-using-ion-molecule-reaction-mass-spectrometry
#4
Lorenzo Monasta, Chiara Pierobon, Andrea Princivalle, Stefano Martelossi, Annalisa Marcuzzi, Francesco Pasini, Luigi Perbellini
Inflammatory bowel diseases (IBD) profoundly affect quality of life and have been gradually increasing in incidence, prevalence and severity in many areas of the world, and in children in particular. Patients with suspected IBD require careful history and clinical examination, while definitive diagnosis relies on endoscopic and histological findings. The aim of the present study was to investigate whether the alveolar air of pediatric patients with IBD presents a specific volatile organic compounds' (VOCs) pattern when compared to controls...
2017: PloS One
https://www.readbyqxmd.com/read/28852307/treating-children-with-inflammatory-bowel-disease-current-and-new-perspectives
#5
REVIEW
Graziella Guariso, Marco Gasparetto
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gut characterised by alternating periods of remission and relapse. Whilst the mechanism underlying this disease is yet to be fully understood, old and newer generation treatments can only target selected pathways of this complex inflammatory process. This narrative review aims to provide an update on the most recent advances in treatment of paediatric IBD. A MEDLINE search was conducted using "paediatric inflammatory bowel disease", "paediatric Crohn's disease", "paediatric ulcerative colitis", "treatment", "therapy", "immunosuppressant", "biologic", "monitoring" and "biomarkers" as key words...
August 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28846760/the-role-of-environmental-factors-in-the-pathogenesis-of-inflammatory-bowel-diseases-a-review
#6
Dror S Shouval, Paul A Rufo
Importance: Inflammatory bowel diseases (IBD), such as Crohn disease and ulcerative colitis, are chronic relapsing conditions that affect a growing number of children worldwide. The pathogenesis of these disorders is complex and thought to be mediated by the interplay between genetic susceptibility, microbial dysbiosis, and environmental factors that result in a dysregulated immune system. This dysregulation ultimately mediates intestinal inflammation and clinical symptoms typically observed in patients with IBD including abdominal pain, diarrhea, and poor growth...
August 28, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28837517/concomitant-therapy-with-immunomodulator-enhances-infliximab-durability-in-pediatric-inflammatory-bowel-disease
#7
Julianna Cheng, Zachary Hamilton, Matthew Smyth, Collin Barker, David Israel, Kevan Jacobson
BACKGROUND: Data on long-term durability of infliximab (IFX) and outcomes of concomitant therapy with immunomodulator in pediatric inflammatory bowel disease are limited. METHODS: Children with inflammatory bowel disease who received IFX ± immunomodulator were retrospectively reviewed. Predictors of induction response were assessed using a binary logistic regression model and long-term outcomes evaluated by Cox proportional hazards model. Propensity score matching examined long-term efficacy of concomitant therapy in patients with Crohn's disease (CD)...
August 22, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28837372/update-upon-efficacy-and-safety-of-etanercept-for-the-treatment-of-spondyloarthritis-and-juvenile-idiopathic-arthritis
#8
Giuseppe Murdaca, Simone Negrini, Ottavia Magnani, Elena Penza, Marco Pellecchio, Rossella Gulli, Paola Mandich, Francesco Puppo
TNF-α inhibitors have demonstrated efficacy both as monotherapy and in combination with disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of chronic inflammatory immune-mediated diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis (AS), psoriasis (Ps) and/or psoriatic arthritis (PsA) and may be administered off-label to treat disseminated granuloma annulare, systemic lupus erythematosus and systemic sclerosis. There are several TNF-α inhibitors available for clinical use including infliximab, adalimumab, golimumab, certolizumab pegol and etanercept...
August 24, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28832362/do-children-and-adolescents-with-inflammatory-bowel-disease-complete-clinical-disease-indices-similar-to-physicians
#9
Kay Diederen, Jorn J Gerritsma, Bart G P Koot, Merit M Tabbers, Marc A Benninga, Angelika Kindermann
OBJECTIVE: The degree to which children and adolescents with inflammatory bowel disease (IBD) complete clinical disease activity indices in accordance with their physician is indefinite. Therefore, we investigated the agreement between patient- and physician-based clinical indices in children and adolescents with a previous diagnosis of IBD. METHODS: In this cross-sectional study, IBD patients (8-18 years) were included prospectively. Patients completed a patient-based short Pediatric Crohn's Disease Activity Index (shPCDAI) for Crohn's disease or the Pediatric Ulcerative Colitis Activity Index (PUCAI) for ulcerative or indeterminate colitis...
August 19, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28797042/cytokine-production-profile-in-intestinal-mucosa-of-paediatric-inflammatory-bowel-disease
#10
Serena Vitale, Caterina Strisciuglio, Laura Pisapia, Erasmo Miele, Pasquale Barba, Alessandra Vitale, Sabrina Cenni, Virginia Bassi, Mariantonia Maglio, Giovanna Del Pozzo, Riccardo Troncone, Annamaria Staiano, Carmen Gianfrani
In the recent years, the incidence of inflammatory bowel disease (IBD) has dramatically increased in young subjects, however, the pathogenesis of paediatric IBD is poorly investigated. In this study we aimed to evaluate the cytokine pattern and the phenotype of cytokine producing cells in the intestinal mucosa of paediatric patients affected by Crohn's disease (CD) or ulcerative colitis (UC) and of non-IBD healthy controls (HC). Cytokine (IL-15, TNF-α, INF-γ) production was analyzed at basal condition and after mitogen stimulation either intracellularly by flow cytometry or in intestinal cell culture supernatants by enzyme-linked immunosorbent assay (ELISA)...
2017: PloS One
https://www.readbyqxmd.com/read/28794097/diagnostic-delay-in-canadian-children-with-inflammatory-bowel-disease-is-more-common-in-crohn-s-disease-and-associated-with-decreased-height
#11
Amanda Ricciuto, Jennifer R Fish, Diane E Tomalty, Nicholas Carman, Eileen Crowley, Cynthia Popalis, Aleixo Muise, Thomas D Walters, Anne M Griffiths, Peter C Church
OBJECTIVES: To determine time to diagnosis in a paediatric inflammatory bowel disease (IBD) cohort and the relative contribution of the component intervals, and to identify factors associated with diagnostic delay. DESIGN: Prospective cohort study SETTING: Single-centre study including children with incident IBD at the Hospital for Sick Children diagnosed between December 2013 and December 2015. INTERVENTIONS: Time to diagnosis and its subintervals were determined and patient, disease and institutional factors were tested for associations...
August 9, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28771805/cutaneous-small-vessel-vasculitis-in-two-children-with-inflammatory-bowel-disease-case-series-and-review-of-the-literature
#12
Tina Ho, Lauren A V Orenstein, Markus D Boos, Kevin P White, Nicole Fett
Cutaneous small-vessel vasculitis (CSVV) is an infrequent manifestation of pediatric inflammatory bowel disease (IBD). We report two cases of CSVV associated with ulcerative colitis, review the literature, and discuss the diagnostic evaluation of children who present with CSVV and abdominal pain. After excluding more common causes of CSVV and abdominal pain in children, including immunoglobulin A vasculitis (previously Henoch-Schönlein purpura), infectious colitis, and drug-induced vasculitis, alternative diagnoses such as CSVV secondary to IBD or systemic vasculitis with gastrointestinal involvement must be considered...
August 2, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28770550/association-of-the-haem-oxygenase-1-gene-with-inflammatory-bowel-disease
#13
Zhenwu Lin, Han Hao, John P Hegarty, Tony R Lin, Yunhua Wang, Leonard R Harris, He N Xu, Rongling Wu, Neal J Thomas, Joanna Floros
The anti-inflammatory genes, haem oxygenase 1 (HO-1, HMOX1) rs2071746 (unrestricted model: p = 9.07 × 10-4; recessive model: p = 4.99 × 10-4; multiplicative model: p = 0.0009; and additive model: p = 1.87 × 10-4) and interleukin-10 (IL-10) rs1800872 (dominant model: p = 0.0277) have been associated with paediatric inflammatory bowel disease. The present family-based case-trio study (n = 52) examined HO-1 gene expression in the presence of proinflammatory lipopolysaccharide and tumour necrosis factor-alpha in four B lymphocyte cell lines established from children with inflammatory bowel disease and demonstrated that mutations in IL-10 and IL-10 receptor B reduced HO-1 messenger RNA expression...
August 3, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28763428/cmv-infection-in-pediatric-severe-ulcerative-colitis-a-multicenter-study-from-the-pediatric-ibd-porto-group-of-espghan
#14
Shlomi Cohen, Christine Martinez-Vinson, Marina Aloi, Dan Turner, Amit Assa, Lissy de Ridder, Victorien M Wolters, Tim de Meij, Patrizia Alvisi, Jiri Bronsky, Uri Kopylov
BACKGROUND: Data on the clinical course and outcomes of pediatric patients with cytomegalovirus (CMV) infection complicating acute severe ulcerative colitis (ASC) are very limited. The aim of our study was to compare outcomes of children with ASC who were CMV-positive or CMV-negative. METHODS: This was a multicenter retrospective case-controlled study, from centers affiliated with the Pediatric IBD Porto Group of ESPGHAN. We included CMV -positive children hospitalized for ASC and compared their colectomy rate during hospitalization and up to 1 year thereafter, matched with CMV-negative controls...
July 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28762696/probiotics-for-gastrointestinal-conditions-a-summary-of-the-evidence
#15
REVIEW
Thad Wilkins, Jacqueline Sequoia
Probiotics contain microorganisms, most of which are bacteria similar to the beneficial bacteria that occur naturally in the human gut. Probiotics have been widely studied in a variety of gastrointestinal diseases. The most-studied species include Lactobacillus, Bifidobacterium, and Saccharomyces. However, a lack of clear guidelines on when to use probiotics and the most effective probiotic for different gastrointestinal conditions may be confusing for family physicians and their patients. Probiotics have an important role in the maintenance of immunologic equilibrium in the gastrointestinal tract through the direct interaction with immune cells...
August 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28759516/swedish-children-s-lived-experience-of-ulcerative-colitis
#16
Vedrana Vejzovic, Ann-Cathrine Bramhagen, Ewa Idvall, Anne Wennick
Inflammatory bowel disease (IBD) is increasing in children. When this lifelong illness is diagnosed in childhood, especially during adolescence, it may have a negative impact on children's quality of life. The aim of the present study was to illuminate the meaning of children's lived experience of ulcerative colitis. Seven children aged between 10 and 18 years were recruited from University Hospital South Sweden and interviewed about the phenomenon under scrutiny. Data were analyzed by means of a phenomenological hermeneutical method...
July 28, 2017: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/28735981/autoimmune-liver-disease-in-children-with-sickle-cell-disease
#17
Suttiruk Jitraruch, Emer Fitzpatrick, Maesha Deheragoda, Annamaria Deganello, Giorgina Mieli-Vergani, Susan Height, David Rees, Nedim Hadzic, Marianne Samyn
OBJECTIVE: To assess the incidence, clinical features, and outcome of autoimmune liver disease (AILD) in patients with sickle cell disease (SCD). STUDY DESIGN: Single center retrospective review of patients with SCD with AILD referred between 1999 and 2015. RESULTS: Thirteen of 77 (17%) patients with SCD with hepatic dysfunction were diagnosed with AILD (median age 11, range, 3.4-16 years) with a female preponderance (77%). Acute hepatitis and insidious onset were the commonest presentations...
July 20, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28728256/-single-center-retrospective-study-of-184-children-with-inflammatory-bowel-disease-seen-from-2000-2014
#18
D X Guan, F H Yu, G L Wang, J Zhou, D Y Wang, X L Nie, X W Xu
Objective: To investigate the clinical data of children with inflammatory bowel disease (IBD) retrospectively, including Crohn's disease (CD) and ulcerative colitis (UC) and identify the clinical characteristics and trends of change. Method: Clinical data of hospitalized patients diagnosed as IBD in Beijing Children's Hospital from January 2000 to December 2014 were collected and retrospectively analyzed. Patients were divided into six groups based on type of disease and year of admission: Group A1(CD, 2000-2004) included 12 patients, Group B1(CD, 2005-2009) included 11, Group C1(CD, 2010-2014) included 51; Group A2(UC, 2000-2004) included 17, Group B2(UC, 2005-2009) included 25, Group C2(UC, 2010-2014) included 68...
July 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28719543/the-association-between-maternal-chronic-inflammatory-bowel-disease-and-long-term-health-outcomes-in-children-a-nationwide-cohort-study
#19
Line R Jølving, Jan Nielsen, Signe S Beck-Nielsen, Rasmus G Nielsen, Sonia Friedman, Ulrik S Kesmodel, Bente M Nørgård
BACKGROUND: Very little is known about the long-term impact of maternal inflammatory bowel disease (IBD) on the offspring's future health. We aimed to examine whether children born to mothers with IBD had an increased risk of long-term morbidities. METHODS: In this nationwide register-based cohort study, including all children born alive in Denmark between 1989 and 2013, we investigated the association between maternal IBD and 15 selected disease categories of physical and mental conditions in the offspring...
August 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28700535/vitamin-d-status-is-associated-with-hepcidin-and-hemoglobin-concentrations-in-children-with-inflammatory-bowel-disease
#20
Sana Syed, Ellen S Michalski, Vin Tangpricha, Supavit Chesdachai, Archana Kumar, Jarod Prince, Thomas R Ziegler, Parminder S Suchdev, Subra Kugathasan
BACKGROUND: Anemia, iron deficiency, and hypovitaminosis D are well-known comorbidities in inflammatory bowel disease (IBD). Epidemiologic studies have linked vitamin D deficiency with increased risk of anemia, and in vitro studies suggest that vitamin D may improve iron recycling through downregulatory effects on hepcidin and proinflammatory cytokines. METHODS: We aimed to investigate the association of vitamin D status with inflammation, iron biomarkers, and anemia in pediatric IBD...
July 11, 2017: Inflammatory Bowel Diseases
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