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https://www.readbyqxmd.com/read/29151253/a-two-week-fecal-microbiota-transplantation-course-in-pediatric-patients-with-inflammatory-bowel-disease
#1
Katarzyna Karolewska-Bochenek, Pawel Grzesiowski, Aleksandra Banaszkiewicz, Agnieszka Gawronska, Maria Kotowska, Marcin Dziekiewicz, Piotr Albrecht, Andrzej Radzikowski, Izabella Lazowska-Przeorek
Dysbiosis plays a major role in the etiology of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) is a new promising option for IBD treatment. We aimed to assess the effectiveness of a two-week FMT course in children with IBD. Ten patients, 10-17 years of age with moderate to severe IBD received a course of eight doses of freshly prepared FMT via a naso-duodenal tube or gastroscopy. All of the patients had pancolitis. There were eight cases of ulcerative colitis (UC) and two of Crohn's disease (CD)...
November 19, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29150304/are-the-estrogenic-hormonal-effects-of-environmental-toxins-affecting-small-intestinal-bacterial-and-microfilaria-overgrowth
#2
Edward Lichten
The important role of microfilaria (worms) in human and animal disease remains an area of key disagreement between the naturopathic and allopathic physicians. While microfilaria infections are rampart in undeveloped countries, they rarely rise to identification as a cause of disease in Western countries. New research studies in the diagnosis and treatment of SIBO (Small Intestinal Bacterial Overgrowth) and (IBD) Inflammatory Bowel Diseases of ulcerative colitis, Crohn's Disease and microcytic colitis may make both sides equally correct...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29140942/minority-pediatric-patients-with-inflammatory-bowel-disease-demonstrate-an-increased-length-of-stay
#3
Edward L Barnes, Bharati Kochar, Millie D Long, Christopher F Martin, Michael D Kappelman
BACKGROUND: Genetic and other biological factors may lead to differences in disease behavior among children with inflammatory bowel disease of different races, which may be further modified by disparities in care delivery. Using the Kids' Inpatient Database, we aimed to evaluate differences in the management of pediatric patients with inflammatory bowel disease by race, focusing on length of stay (LOS). METHODS: We performed a cross-sectional analysis using 2000 to 2012 data from the Kids' Inpatient Database, a nationally representative database...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29140453/faecal-transplantation-for-ibd-management-pitfalls-and-promises
#4
M N Quraishi, T Critchlow, N Bhala, N Sharma, T Iqbal
Background: Faecal microbiota transplantation (FMT) as a potential treatment for inflammatory bowel disease (IBD) is an area of active current research, having been stimulated by the remarkable efficacy of FMT in treatment of Clostridium difficile-associated colitis. Sources of data: This review is based on data from numerous case series on FMT in IBD since 1989 and results of four RCTs in ulcerative colitis (UC); three fully published. Areas of agreement: Early signals of short to medium-term efficacy of FMT for UC are promising...
November 13, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29132528/an-update-on-inflammatory-bowel-disease
#5
REVIEW
Tomoko Sairenji, Kimberly L Collins, David V Evans
Inflammatory bowel disease (IBD) includes 2 chronic idiopathic inflammatory diseases: ulcerative colitis and Crohn disease. The incidence and prevalence of IBD is increasing worldwide. It can affect people of all ages, including children and geriatric populations, and can impact all aspects of life. In this article, diagnosis and treatment of IBD in adults, pediatric, pregnant, and elderly populations are explored from the perspective of a primary care physician.
December 2017: Primary Care
https://www.readbyqxmd.com/read/29126510/long-term-outcomes-of-pediatric-inflammatory-bowel-disease
#6
Soheila Nasiri, Mary Ellen Kuenzig, Eric I Benchimol
The incidence and prevalence of childhood-onset inflammatory bowel diseases (IBD), including subtypes Crohn's disease and ulcerative colitis, have risen dramatically in recent years, and have emerged globally as important pediatric chronic diseases. Therefore, health care providers are more frequently encountering very young children with IBD, a chronic and incurable condition requiring life-long therapy. These children are living long lives with IBD and therefore knowledge of long-term outcomes is increasingly important to better counsel families and determine the best course of treatment...
December 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29126508/complications-in-children-with-ulcerative-colitis-undergoing-ileal-pouch-anal-anastomosis
#7
Dani O Gonzalez, Benedict C Nwomeh
Total colectomy with ileal pouch-anal anastomosis (IPAA) is considered the standard procedure for the surgical management of ulcerative colitis. Despite the widespread utility of the procedure, as many as 75% of patients who undergo IPAA, experience at least 1 complication. This review highlights difficult intraoperative scenarios and complications of pouch surgery in children, including intraoperative, postoperative, and functional complications. Intraoperative scenarios include insufficient mesenteric length and positive leak tests...
December 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29126507/surgical-options-in-the-treatment-of-ulcerative-colitis
#8
Daniel P Ryan, Daniel P Doody
Children and young adults with ulcerative colitis tend to present with more extensive colonic disease than an adult population. The need for surgical intervention in the pediatric population with ulcerative colitis occurs earlier after diagnosis and has a greater incidence than a comparably matched adult population with an estimated need for colectomy at 5 years following diagnosis of 14-20%. Perhaps, even more than the adult population, there is a desire to restore intestinal continuity for the pediatric patient to achieve as healthy and normal quality of life as possible...
December 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29126505/management-of-acute-severe-ulcerative-colitis-in-children
#9
Vei Shaun Siow, Riha Bhatt, Kevin P Mollen
The incidence of pediatric-onset ulcerative colitis (UC) is rising. Children often present with a more severe disease phenotype as compared to adults with over a third requiring hospitalization for the management of acute severe ulcerative colitis (ASUC). Further, in pediatric patients presenting with inflammatory bowel disease (IBD) limited to the colon, a definitive diagnosis of UC vs. Crohn's disease is often unclear. Here, we review the unique aspects of pediatric ASUC including the epidemiology, diagnosis, medical, and surgical management of this disease...
December 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29126502/clinical-presentation-of-crohn-s-ulcerative-colitis-and-indeterminate-colitis-symptoms-extraintestinal-manifestations-and-disease-phenotypes
#10
Yangyang R Yu, J Ruben Rodriguez
The incidence of inflammatory bowel disease (IBD) is rising with 25% of IBD diagnosed in children under 18 years of age. The clinical presentation of IBD in children is often vague leading to initial misdiagnosis as infectious colitis or irritable bowel syndrome. When IBD is identified, overlap in histologic and endoscopic features may lead to difficulty distinguishing Crohn's disease from ulcerative colitis, resulting in a higher frequency of the diagnosis indeterminate colitis or IBD unspecified. Recognizing the common and the atypical presentation of pediatric IBD and extraintestinal manifestations will aid in expeditious referral and early diagnosis...
December 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29123578/the-role-of-adhesion-molecules-in-inflammatory-bowel-disease-in-children-assessment-of-the-possible-risk-of-cardiovascular-complications
#11
Aneta Trzeciak-Jędrzejczyk, Ryszard Makosiej, Michał Kolejwa, Ewa Głowacka, Elżbieta Czkwianianc
Introduction: Inflammatory bowel diseases (IBD) are chronic diseases that proceed with exacerbation and remission phases. Adhesion molecules play a significant role in inflammatory processes. The same adhesion molecules play an important role in atherogenesis. Aim: To assess the risk of atherosclerosis in IBD in children. Material and methods: The study included 40 patients with IBD (25 with Crohn's disease - CD and 15 with ulcerative colitis - UC) aged 4-17 years...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29103786/reduced-paraspinous-muscle-area-is-associated-with-post-colectomy-complications-in-children-with-ulcerative-colitis
#12
Priya H Dedhia, Yasmine White, Jonathan R Dillman, Jeremy Adler, Marcus D Jarboe, Daniel H Teitelbaum, Ronald B Hirschl, Samir K Gadepalli
BACKGROUND AND OBJECTIVES: Sarcopenia, defined as reduced muscle mass, is typically assessed by CT scans, which are infrequently performed in children. Using MRI to measure sarcopenia, we determined the association with postoperative complications after colectomy for ulcerative colitis (UC). METHODS: Clinical and preoperative MRI data for 13-18-year-old UC patients who underwent colectomy were retrospectively reviewed. Bilateral paraspinous muscle area (PSMA) and psoas muscle area (PMA) at L3 vertebra were measured and averaged...
September 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29089273/histological-features-of-ileitis-differentiating-pediatric-crohn-disease-from-ulcerative-colitis-with-backwash-ileitis
#13
Benjamin Sahn, Vera De Matos, Ronen Stein, Eduardo Ruchelli, Samuel Masur, Andrew J Klink, Robert N Baldassano, David A Piccoli, Pierre Russo, Petar Mamula
BACKGROUND/AIM: Pediatric ileocolonic Crohn disease (CD) may be difficult to distinguish from ulcerative colitis (UC) with backwash ileitis (BWI). The primary aim of the study was to determine the probability of CD in children with a confluent colitis and ileitis when newly diagnosed with inflammatory bowel disease (IBD). METHODS: A retrospective observational study of 100 newly diagnosed patients with IBD was performed. Two pathologists reviewed ileal biopsy specimens for 8 histological features...
October 19, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29084080/metronidazole-or-rifaximin-for-treatment-of-clostridium-difficile-in-pediatric-patients-with-inflammatory-bowel-disease-a-randomized-clinical-trial
#14
Agnieszka Gawronska, Marcin Banasiuk, Dominika Lachowicz, Hanna Pituch, Piotr Albrecht, Aleksandra Banaszkiewicz
BACKGROUND: Interestingly, Clostridium difficile infection (CDI) worsens the course of inflammatory bowel disease (IBD); however, there is a paucity of data regarding the treatment of CDI in this group of patients. METHODS: This was a prospective, single-blind trial. Children with flare of IBD and CDI were randomly assigned to receive metronidazole or rifaximin orally for 14 days. CDI was diagnosed based on a positive well-type enzyme immunoassay (EIA) toxins A/B stool test for C...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29077643/prospective-incidence-of-paediatric-inflammatory-bowel-disease-in-new-zealand-in-2015-results-from-the-pinz-study
#15
Robert N Lopez, Helen M Evans, Laura Appleton, Jonathan Bishop, Simon Chin, Stephen Mouat, Richard B Gearry, Andrew S Day
BACKGROUND: The global incidence of paediatric inflammatory bowel disease (IBD) is increasing. Much of the evidence attesting to this has arisen from North America and Europe. There is a relative paucity of information on the epidemiology of paediatric IBD in the Southern Hemisphere. This study aimed to document the prospectively-collected incidence of paediatric IBD in New Zealand in 2015. METHODS: All patients under 16 years of age and diagnosed with IBD in New Zealand between 1 January 2015 and 31 December 2015 were identified...
October 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29075621/pancreatic-involvement-in-pediatric-inflammatory-bowel-disease
#16
REVIEW
Javier Martín-de-Carpi, Melinda Moriczi, Gemma Pujol-Muncunill, Victor M Navas-López
Inflammatory bowel disease (IBD) is a chronic condition that includes two clinical entities: Crohn's disease and ulcerative colitis. Although both entities mainly affect the gastrointestinal tract are considered multisystemic diseases and may present extraintestinal manifestations involving other organs and systems. Pancreatic involvement in Pediatric IBD includes a heterogeneous group of clinical entities like acute pancreatitis, chronic pancreatitis, autoimmune pancreatitis, asymptomatic exocrine pancreatic insufficiency, increased pancreatic enzyme levels, structural abnormalities, and granulomatous inflammation...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29067041/paediatric-inflammatory-bowel-disease-clinical-presentation-and-disease-location
#17
Danish Abdul Aziz, Maryum Moin, Atif Majeed, Kamran Sadiq, Abdul Gaffar Biloo
OBJECTIVE: To determine different clinical presentationsand disease location demarcatedby upper and lower gastrointestinal endoscopyand relevant histopathologyin children diagnosed with inflammatory bowel disease (IBD). METHODS: This is 5 years (2010 to 2015) retrospective studyconducted at the Aga Khan University Hospitalenrolling65admitted children between 6 months to 15years from either gender, diagnosed with IBD on clinical presentation, endoscopy and biopsy...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29064856/bone-mass-development-from-childhood-into-young-adulthood-in-patients-with-childhood-onset-inflammatory-bowel-disease
#18
Gudmundur Vignir Sigurdsson, Susanne Schmidt, Dan Mellström, Claes Ohlsson, Jenny M Kindblom, Mattias Lorentzon, Robert Saalman
BACKGROUND: Children who have inflammatory bowel disease (IBD) have increased risk of low bone mineral density (BMD). There is a scarcity of information on BMD development through puberty and into young adulthood in patients with childhood-onset IBD. METHODS: We conducted a prospective longitudinal study of BMD in patients with childhood-onset IBD. In total, 74 children with IBD were followed into young adulthood, with a mean follow-up of 8.4 years. The BMD was assessed longitudinally using dual-energy X-ray absorptiometry of the lumbar spine, total hip and whole body, and related to anthropometric measures...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29049404/low-complexity-microbiota-in-the-duodenum-of-children-with-newly-diagnosed-ulcerative-colitis
#19
Fei Sjöberg, Cecilia Barkman, Intawat Nookaew, Sofia Östman, Ingegerd Adlerberth, Robert Saalman, Agnes E Wold
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by gut dysbiosis. To date, the large bowel microbiota has been in focus. However, the microbiota of the small intestine may also be of importance, as the small bowel is a site for the induction and control of mucosal immune responses, which can be modulated by constituents of the local microbiota. METHODS: Duodenal fluids were collected during diagnostic work-up of treatment-naïve children who were suspected of having IBD...
2017: PloS One
https://www.readbyqxmd.com/read/29037795/the-burden-of-hospital-readmissions-among-pediatric-patients-with-inflammatory-bowel-disease
#20
Edward L Barnes, Bharati Kochar, Millie D Long, Christopher F Martin, Seth D Crockett, Joshua R Korzenik, Michael D Kappelman
OBJECTIVE: To evaluate the burden and predictors of hospital readmissions among pediatric patients with inflammatory bowel disease using the Nationwide Readmissions Database. STUDY DESIGN: We performed a retrospective cohort study using 2013 Nationwide Readmissions Database. International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to identify patients <18 years with diagnoses of ulcerative colitis (UC) or Crohn's disease (CD)...
October 13, 2017: Journal of Pediatrics
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