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Microvascular imaging

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https://www.readbyqxmd.com/read/29050294/the-density-of-mast-cells-c-kit-and-tryptase-correlates-with-each-other-and-with-angiogenesis-in-pancreatic-cancer-patients
#1
Michele Ammendola, Cosmo Damiano Gadaleta, Adam Enver Frampton, Tullio Piardi, Riccardo Memeo, Valeria Zuccalà, Maria Luposella, Rosa Patruno, Nicola Zizzo, Pietro Gadaleta, Patrick Pessaux, Rosario Sacco, Giuseppe Sammarco, Girolamo Ranieri
Literature data suggest that inflammatory cells such as mast cells (MCs) are involved in angiogenesis. MCs can stimulate angiogenesis by releasing of well identified pro-angiogenic cytokines stored in their cytoplasm. In particular, MCs can release tryptase, a potent in vivo and in vitro pro-angiogenic factor. Nevertheless, few data are available concerning the role of MCs positive to tryptase in primary pancreatic cancer angiogenesis. This study analyzed the correlation between mast cells positive to c-Kit receptor (c-Kit(+) MCs), the density of MCs expressing tryptase (MCD-T) and microvascular density (MVD) in primary tumor tissue from patients affected by pancreatic ductal adenocarcinoma (PDAC)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049034/complex-based-oct-angiography-algorithm-recovers-microvascular-information-superior-to-amplitude-or-phase-based-algorithm-in-phase-stable-systems
#2
Jingjiang Xu, Shaozhen Song, Yuandong Li, Ruikang K Wang
Optical coherence tomography angiography (OCTA) is increasingly becoming a popular inspection tool for biomedical imaging applications. By exploring amplitude, phase and complex information available in the OCT signals, numerous algorithms are proposed to contrast functional vessel networks with microcirculation tissue beds. However, it is not clear which algorithm delivers optimal imaging performance. Here, we investigate systematically how the amplitude and phase information would have an impact on the OCTA imaging performance, upon which to establish the relationship of amplitude and phase stability with OCT signal-to-noise ratio (SNR), time interval and particle dynamics...
October 19, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29047411/mildly-elevated-lactate-levels-are-associated-with-microcirculatory-flow-abnormalities-and-increased-mortality-a-microsoap-post-hoc-analysis
#3
Namkje A R Vellinga, E Christiaan Boerma, Matty Koopmans, Abele Donati, Arnaldo Dubin, Nathan I Shapiro, Rupert M Pearse, Peter H J van der Voort, Arjen M Dondorp, Tony Bafi, Michael Fries, Tulin Akarsu-Ayazoglu, Andrius Pranskunas, Steven Hollenberg, Gianmarco Balestra, Mat van Iterson, Farid Sadaka, Gary Minto, Ulku Aypar, F Javier Hurtado, Giampaolo Martinelli, Didier Payen, Frank van Haren, Anthony Holley, Hernando Gomez, Ravindra L Mehta, Alejandro H Rodriguez, Carolina Ruiz, Héctor S Canales, Jacques Duranteau, Peter E Spronk, Shaman Jhanji, Sheena Hubble, Marialuisa Chierego, Christian Jung, Daniel Martin, Carlo Sorbara, Jan Bakker, Can Ince
BACKGROUND: Mildly elevated lactate levels (i.e., 1-2 mmol/L) are increasingly recognized as a prognostic finding in critically ill patients. One of several possible underlying mechanisms, microcirculatory dysfunction, can be assessed at the bedside using sublingual direct in vivo microscopy. We aimed to evaluate the association between relative hyperlactatemia, microcirculatory flow, and outcome. METHODS: This study was a predefined subanalysis of a multicenter international point prevalence study on microcirculatory flow abnormalities, the Microcirculatory Shock Occurrence in Acutely ill Patients (microSOAP)...
October 18, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29043853/microvascular-network-and-its-endothelial-cells-in-the-human-iris
#4
Hongfang Yang, Paula K Yu, Stephen J Cringle, Xinghuai Sun, Dao-Yi Yu
PURPOSE: The iris allows effective delivery of nutrients into the aqueous humor supplying the surrounded avascular tissues. However, possible underlying mechanisms of the iris vasculature have not been well established. This study aims to quantitatively assess the human iris vascular network, endothelial cell morphometries, and characterize endothelial junctions to better understand the properties of the iris vasculature. MATERIALS AND METHODS: The irises from human donor eyes were dissected and short fixed before float staining for VE-cadherin and claudin-5, f-actin and nuclei and flat-mounted for confocal imaging...
October 18, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29040211/altered-macular-microvasculature-in-mild-cognitive-impairment-and-alzheimer-disease
#5
Hong Jiang, Yantao Wei, Yingying Shi, Clinton B Wright, Xiaoyan Sun, Giovanni Gregori, Fang Zheng, Elizabeth A Vanner, Byron L Lam, Tatjana Rundek, Jianhua Wang
BACKGROUND: The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). METHODS: Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP)...
October 16, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29038969/microvascular-imaging-and-monitoring-of-human-oral-cavity-lesions-in-vivo-by-swept-source-oct-based-angiography
#6
Wei Wei, Woo June Choi, Ruikang K Wang
We report the development of optical coherence tomography- (OCT) based angiography (OCTA) to image blood flow within microcirculatory tissue beds in human oral cavity in vivo with a field of view at 10 mm × 10 mm. Three-dimensional (3D) structural and vascular images of labial mucosa tissue are obtained at a single 3D acquisition. Pathologic mucosal sites with mouth ulcers are examined using the OCT tomograms and angiograms, upon which to monitor the lesion healing process over a period of 2 weeks. Quantitative metrics of the capillary loop density within the lamina propria layer are evaluated, providing statistically significant difference between healthy and diseased conditions over time...
October 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29025210/up-to-date-doppler-techniques-for-breast-tumor-vascularity-superb-microvascular-imaging-and-contrast-enhanced-ultrasound
#7
Ah Young Park, Bo Kyoung Seo
Ultrasonographic Doppler techniques have improved greatly over the years, allowing more sophisticated evaluation of breast tumor vascularity. Superb microvascular imaging (SMI) and contrast-enhanced ultrasound (CEUS) with second-generation contrast agents are two representative up-to-date techniques. SMI is a sensitive Doppler technique that adopts an intelligent filter system to separate low-flow signals from artifacts. With the development of second-generation contrast agents, CEUS has also emerged as a useful Doppler technique for evaluating tumor microcirculation...
August 19, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29023881/review-article-the-role-of-the-microcirculation-in-liver-cirrhosis
#8
REVIEW
T Davies, S Wythe, J O'Beirne, D Martin, E Gilbert-Kawai
BACKGROUND: Intrahepatic microvascular derangements and microcirculatory dysfunction are key in the development of liver cirrhosis and its associated complications. While much has been documented relating to cirrhosis and the dysfunction of the microcirculation in the liver parenchyma, far less is known about the state of the extrahepatic microcirculation and the role this may have in the pathogenesis of multiple organ failure in end stage liver cirrhosis. AIM: To provide an update on the role of the microcirculation in the pathophysiology of cirrhosis and its associated complications and briefly discuss some of the imaging techniques which may be used to directly investigate the microcirculation...
November 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29022101/microflow-imaging-new-doppler-technology-to-detect-low-grade-inflammation-in-patients-with-arthritis
#9
A K P Lim, K Satchithananda, E A Dick, S Abraham, D O Cosgrove
AIM: To assess the efficacy of microvascular imaging in detecting low-grade inflammation in arthritis compared with Power Doppler ultrasound (PDUS). METHOD AND MATERIALS: Patients presenting for ultrasound with arthralgia were assessed with grey-scale, PDUS and Superb Microvascular Imaging (SMI). Videoclips were stored for analysis at a later date. Three musculoskeletal radiologists scored grey-scale changes, signal on PDUS and/or SMI within these joints. If a signal was detected on both PDUS and SMI, the readers graded the conspicuity of vascular signal from the two Doppler techniques using a visual analogue scale...
October 11, 2017: European Radiology
https://www.readbyqxmd.com/read/29021164/investigation-of-microvascular-morphological-measures-for-skeletal-muscle-tissue-oxygenation-by-image-based-modelling-in-three-dimensions
#10
B Zeller-Plumhoff, K R Daly, G F Clough, P Schneider, T Roose
The supply of oxygen in sufficient quantity is vital for the correct functioning of all organs in the human body, especially for skeletal muscle during exercise. Traditionally, microvascular oxygen supply capability is assessed by the analysis of morphological measures on transverse cross-sections of muscle, e.g. capillary density or capillary-to-fibre ratio. In this work, we investigate the relationship between microvascular structure and muscle tissue oxygenation in mice. Phase contrast imaging was performed using synchrotron radiation computed tomography (SR CT) to visualize red blood cells (RBCs) within the microvasculature in mouse soleus muscle...
October 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29020248/relationship-between-microvascular-obstruction-and-adverse-events-following-primary-primary-percutaneous-coronary-intervention-for-st-segment-elevation-myocardial-infarction-an-individual-patient-data-pooled-analysis-from-seven-randomized-trials
#11
Suzanne de Waha, Manesh R Patel, Christopher B Granger, E Magnus Ohman, Akiko Maehara, Ingo Eitel, Ori Ben-Yehuda, Paul Jenkins, Holger Thiele, Gregg W Stone
Aims: Microvascular obstruction (MVO) is the underlying cause for the no-reflow phenomenon in ST-segment elevation myocardial infarction (STEMI). The association between MVO assessed by cardiac magnetic resonance imaging (CMR) and prognosis has not been convincingly demonstrated. We sought to determine the relationship between MVO assessed early after primary percutaneous coronary intervention (PCI) in STEMI and all-cause mortality, hospitalization for heart failure (HF), and reinfarction...
July 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29018924/rapid-volumetric-photoacoustic-tomographic-imaging-with-a-fabry-perot-ultrasound-sensor-depicts-peripheral-arteries-and-microvascular-vasomotor-responses-to-thermal-stimuli
#12
Andrew A Plumb, Nam Trung Huynh, Jamie Guggenheim, Edward Zhang, Paul Beard
PURPOSE: To determine if a new photoacoustic imaging (PAI) system successfully depicts (1) peripheral arteries and (2) microvascular circulatory changes in response to thermal stimuli. METHODS: Following ethical permission, 8 consenting subjects underwent PAI of the dorsalis pedis (DP) artery, and 13 completed PAI of the index fingertip. Finger images were obtained after immersion in warm (30-35 °C) or cold (10-15 °C) water to promote vasodilation or vasoconstriction...
October 10, 2017: European Radiology
https://www.readbyqxmd.com/read/29018020/relation-of-low-density-lipoprotein-cholesterol-with-microvascular-injury-and-clinical-outcome-in-revascularized-st-elevation-myocardial-infarction
#13
Martin Reindl, Sebastian Johannes Reinstadler, Hans-Josef Feistritzer, Markus Theurl, Daniel Basic, Christopher Eigler, Magdalena Holzknecht, Johannes Mair, Agnes Mayr, Gert Klug, Bernhard Metzler
BACKGROUND: Microvascular injury (MVI) after primary percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI) is a major determinant of adverse clinical outcome. Experimental data indicate an impact of hypercholesterolemia on MVI; however, there is a lack of clinical studies confirming this relation. We aimed to investigate the association of cholesterol concentrations on admission with MVI visualized by cardiac magnetic resonance imaging and clinical outcome in STEMI patients treated by primary percutaneous coronary intervention...
October 10, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28987671/dual-energy-spectral-ct-imaging-for-the-evaluation-of-small-hepatocellular-carcinoma-microvascular-invasion
#14
Chuang-Bo Yang, Shuang Zhang, Yong-Jun Jia, Yong Yu, Hai-Feng Duan, Xi-Rong Zhang, Guang-Ming Ma, Chenglong Ren, Nan Yu
OBJECTIVE: To study the clinical value of dual-energy spectral CT in the quantitative assessment of microvascular invasion of small hepatocellular carcinoma. METHODS: This study was approved by our ethics committee. 50 patients with small hepatocellular carcinoma who underwent contrast enhanced spectral CT in arterial phase (AP) and portal venous phase (VP) were enrolled. Tumour CT value and iodine concentration (IC) were measured from spectral CT images. The slope of spectral curve, normalized iodine concentration (NIC, to abdominal aorta) and ratio of IC difference between AP and VP (RICAP-VP: [RICAP-VP=(ICAP-ICVP)/ICAP]) were calculated...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987229/controversies-in-oral-and-maxillofacial-oncology
#15
REVIEW
Jacob G Yetzer
Imaging studies are essential components of tumor diagnosis, staging, assessing tumor response to neoadjuvant and adjuvant therapies, and postoperative surveillance on completion of definitive treatment. Treatment of early stage clinically node negative oral cavity squamous cell carcinoma is controversial. Approximately 3% of all head and neck tumors arise within the parotid gland and most often within the superficial lobe, lateral to the facial nerve; about 80% are benign and most are pleomorphic adenoma. In patients with dry eyes failing multiple other treatment modalities and facing ongoing pain and loss of vision, microvascular transplant of the submandibular gland is a viable option...
November 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28983872/pearls-and-pitfalls-of-optical-coherence-tomography-angiography-in-the-multimodal-evaluation-of-uveitis
#16
REVIEW
Francesco Pichi, David Sarraf, Mariachiara Morara, Shahana Mazumdar, Piergiorgio Neri, Vishali Gupta
BACKGROUND: Optical coherence tomography angiography (OCTA) employs a novel imaging algorithm that detects the amplitude or phase decorrelation of blood cell movement. It thus provides a flow map with depth-resolved visualization of the various vascular layers in the posterior pole of the eye including the retina capillary plexus and the choroid. In the past 3 years, the number of research papers on the subject of OCTA in retinal diseases has grown exponentially including important applications in the field of uveitis...
October 5, 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28980419/organotypic-brain-explant-culture-as-a-drug-evaluation-system-for-malignant-brain-tumors
#17
Noriaki Minami, Yusuke Maeda, Shunsuke Shibao, Yoshimi Arima, Fumiharu Ohka, Yutaka Kondo, Koji Maruyama, Masatoshi Kusuhara, Takashi Sasayama, Eiji Kohmura, Hideyuki Saya, Oltea Sampetrean
Therapeutic options for malignant brain tumors are limited, with new drugs being continuously evaluated. Organotypic brain slice culture has been adopted for neuroscience studies as a system that preserves brain architecture, cellular function, and the vascular network. However, the suitability of brain explants for anticancer drug evaluation has been unclear. We here adopted a mouse model of malignant glioma based on expression of H-Ras(V12) in Ink4a/Arf(-/-) neural stem/progenitor cells to establish tumor-bearing brain explants from adult mice...
October 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28975635/towards-optimization-of-in-vivo-super-resolution-ultrasound-imaging-using-size-selected-microbubble-contrast-agents
#18
Debabrata Ghosh, Fangyuan Xiong, Shashank R Sirsi, Philip W Shaul, Robert F Mattrey, Kenneth Hoyt
PURPOSE: Microvascular processes play key roles in many diseases including diabetes. Improved understanding of the microvascular changes involved in disease development could offer crucial insight into the relationship of these changes to disease pathogenesis. Super-resolution ultrasound (SR-US) imaging has showed the potential to visualize microvascular detail down to the capillary level (i.e., subwavelength resolution) but optimization is still necessary. The purpose of this study was to investigate in vivo SR-US imaging of skeletal muscle microvascularity using microbubble (MB) contrast agents of various size and concentration while evaluating different ultrasound (US) system level parameters such as imaging frame rate and image acquisition length...
October 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28966577/neurovascular-interaction-promotes-the-morphological-and-functional-maturation-of-cortical-neurons
#19
Kun-Wei Wu, Jia-Lin Mo, Zeng-Wei Kou, Qi Liu, Ling-Ling Lv, Yu Lei, Feng-Yan Sun
Brain microvascular endothelial cells (BMEC) have been found to guide the migration, promote the survival and regulate the differentiation of neural cells. However, whether BMEC promote development and maturation of immature neurons is still unknown. Therefore, in this study, we used a direct endothelium-neuron co-culture system combined with patch clamp recordings and confocal imaging analysis, to investigate the effects of endothelial cells on neuronal morphology and function during development. We found that endothelial cells co-culture or BMEC-conditioned medium (B-CM) promoted neurite outgrowth and spine formation, accelerated electrophysiological development and enhanced synapse function...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28965229/treatment-of-blepharospasm-hemifacial-spasm
#20
REVIEW
Kemar E Green, David Rastall, Eric Eggenberger
The treatment of both hemifacial spasm (HFS) and blepharospasm (BEB) requires making the appropriate clinical diagnosis. Advance imaging and electrophysiologic studies are useful; however, one's clinical suspicion is paramount. The purpose of this review is to summarize current and emerging therapies for both entities. Botulinum toxin (BTX) remains the first-line therapy to treat both conditions. If chemodenervation has failed, surgery may be considered. Due to the risks associated with surgery, the benefits of this option must be carefully weighed...
September 30, 2017: Current Treatment Options in Neurology
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