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Microvascular imaging

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https://www.readbyqxmd.com/read/29449598/health-related-quality-of-life-in-adolescents-and-the-retinal-microvascular-structure
#1
Bamini Gopinath, Gerald Liew, George Burlutsky, Louise A Baur, Paul Mitchell
We aimed to investigate whether health-related quality of life (HRQoL) is associated with retinal vascular caliber, an indicator of subclinical cardiovascular disease risk. 1600 students aged between 11-19 years (821 girls and 779 boys) were examined during 2009-2011. Retinal vessel caliber was measured from digital retinal images. HRQoL was assessed by the Pediatric Quality of Life Inventory (PedsQL). In the overall cohort, each 1-unit increase in PedsQL total score and the psychosocial summary score was associated with ~0...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444696/bedside-analysis-of-the-sublingual-microvascular-glycocalyx-in-the-emergency-room-and-intensive-care-unit-the-glyconurse-study
#2
Alexandros Rovas, Alexander-Henrik Lukasz, Hans Vink, Marc Urban, Jan Sackarnd, Hermann Pavenstädt, Philipp Kümpers
BACKGROUND: Deterioration of the endothelial glycocalyx (eGC), a protective carbohydrate-rich layer lining the luminal surface of the endothelium, plays a key role in vascular barrier dysfunction and eventually organ-failure in systemic inflammatory response syndrome and sepsis. Early detection of glycocalyx damage could thus become an important goal in critical care. This study was designed to determine the feasibility and reproducibility of quantitative, real-time glycocalyx measurements performed at bedside in the emergency room (ER) and intensive care unit (ICU)...
February 14, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29443808/retinal-microvasculature-alteration-in-paracentral-acute-middle-maculopathy-and-acute-macular-neuroretinopathy-a-quantitative-optical-coherence-tomography-angiography-study
#3
Alexei N Kulikov, Dmitrii S Maltsev, Tatiana A Leongardt
PURPOSE: To present a series of idiopathic paracentral acute middle maculopathy (PAMM) and acute macular neuroretinopathy (AMN) cases and to compare the microvascular retinal status of PAMM/AMN eyes with those of healthy individuals. METHODS: Six eyes with PAMM and two eyes with AMN in a total of six patients were included in this study. Multimodal retinal imaging, including optical coherence tomography angiography, was performed in all patients. The vessel density of the superficial capillary plexus and deep capillary plexus, as well as the area, circularity, and angle of the superficial foveal avascular zone (FAZ) were measured and compared with the same parameters in age-matched healthy individuals...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29439196/reduced-intravoxel-incoherent-motion-microvascular-perfusion-predicts-delayed-cerebral-ischemia-and-vasospasm-after-aneurysm-rupture
#4
Jeremy J Heit, Max Wintermark, Blake W Martin, Guangming Zhu, Michael P Marks, Greg Zaharchuk, Robert L Dodd, Huy M Do, Gary K Steinberg, Maarten G Lansberg, Gregory W Albers, Christian Federau
BACKGROUND AND PURPOSE: Proximal artery vasospasm and delayed cerebral ischemia (DCI) after cerebral aneurysm rupture result in reduced cerebral perfusion and microperfusion and significant morbidity and mortality. Intravoxel incoherent motion (IVIM) magnetic resonance imaging extracts microvascular perfusion information from a multi-b value diffusion-weighted sequence. We determined whether decreased IVIM perfusion may identify patients with proximal artery vasospasm and DCI. METHODS: We performed a pilot retrospective cohort study of patients with ruptured cerebral aneurysms...
February 9, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29434710/assessment-of-dermal-papillary-and-microvascular-parameters-in-psoriasis-vulgaris-using-in-vivo-reflectance-confocal-microscopy
#5
Alexandra Batani, Daciana Elena Brănișteanu, Mihaela Adriana Ilie, Daniel Boda, Simona Ianosi, Gabriel Ianosi, Constantin Caruntu
In vivo reflectance confocal microscopy (RCM) is a modern, non-invasive imaging technique, which allows for real-time examination of the upper layers of the skin at a resolution similar to that of classic microscopy. In addition, it has the advantage of real-time evaluation of blood flow and dynamic monitoring of cutaneous changes while preserving tissue integrity. The present study reported on the in vivo RCM technique as an objective method for the noninvasive assessment of psoriasis vulgaris that is potentially applicable in clinical studies and in monitoring the evolution of lesions under treatment...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29430938/visibility-of-the-graft-hepatic-artery-using-superb-microvascular-imaging-in-liver-transplantation-recipients-initial-experience
#6
Hye Young Jang, Kyoung Won Kim, So Yeon Kim, Jin Sil Kim, Sang Hyun Choi, Se-Young Kim, Sung-Gyu Lee
Background Hepatic artery (HA) obstruction is one of the most threatening complications following liver transplantation (LT); however, conventional color Doppler imaging (CDI) suffers from technical limitations regarding the visualization of fine vessels and low-velocity blood flow. Purpose To test the visibility of HA in postoperative evaluation of LT using a superb microvascular imaging (SMI). Material and Methods This retrospective study was approved by our institutional review board. Fifty-five consecutive patients (58 grafts; mean age = 56 years) who underwent LT with Doppler ultrasonography (US) on postoperative day 1 were included...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29429361/-evaluation-of-diabetic-microangiopathy-using-optical-coherence-tomography-angiography
#7
Cecília Czakó, Gábor László Sándor, Mónika Ecsedy, Zsuzsanna Szepessy, Ágnes Borbándy, Miklós Resch, András Papp, Zsuzsa Récsán, Hajnalka Horváth, Zoltán Zsolt Nagy, Illés Kovács
INTRODUCTION: Optical coherence tomography angiography is a non-invasive imaging technique that is able to visualize the different retinal vascular layers using motion contrast to detect blood flow without intravenous dye injection. This method might help to assess microangiopathy in diabetic retinopathy during screening and follow-up. AIM: To quantify retinal microvasculature alterations in both eyes of diabetic patients in relation to systemic risk factors using optical coherence tomography angiography...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29425330/trigeminal-nerve-compression-without-trigeminal-neuralgia-intraoperative-vs-imaging-evidence
#8
Ronak H Jani, Marion A Hughes, Michael S Gold, Barton F Branstetter, Zachary E Ligus, Raymond F Sekula
BACKGROUND: While high-resolution imaging is increasingly used in guiding decisions about surgical interventions for the treatment of trigeminal neuralgia, direct assessment of the extent of vascular contact of the trigeminal nerve is still considered the gold standard for the determination of whether nerve decompression is warranted. OBJECTIVE: To compare intraoperative and magnetic resonance imaging (MRI) findings of the prevalence and severity of vascular compression of the trigeminal nerve in patients without classical trigeminal neuralgia...
February 6, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29417380/assessing-long-term-neuroinflammatory-responses-to-encephalopathy-using-mri-approaches-in-a-rat-endotoxemia-model
#9
Rheal A Towner, D Saunders, N Smith, W Towler, M Cruz, S Do, J E Maher, K Whitaker, M Lerner, K A Morton
Sepsis-associated encephalopathy (SAE) induces neuroinflammation, which is associated with cognitive impairment (CI). CI is also correlated with aging. We used contrast-enhanced magnetic resonance imaging (MRI), perfusion MRI, and MR spectroscopy to assess long-term alterations in BBB permeability, microvascularity, and metabolism, respectively, in a rat lipopolysaccharide-induced SAE model. Free radical-targeted molecular MRI was used to detect brain radical levels at 24 h and 1 week post-LPS injection. CE-MRI showed increased Gd-DTPA uptake in LPS rat brains at 24 h in cerebral cortex, hippocampus, thalamus, and perirhinal cortex regions...
February 7, 2018: GeroScience
https://www.readbyqxmd.com/read/29410063/meningioma-assessment-kinetic-parameters-in-dynamic-contrast-enhanced-mri-appear-independent-from-microvascular-anatomy-and-vegf-expression
#10
Vera C Keil, Bogdan Pintea, Gerrit H Gielen, Kanishka Hittatiya, Angeliki Datsi, Matthias Simon, Rolf Fimmers, Hans H Schild, Dariusch R Hadizadeh
BACKGROUND AND PURPOSE: Kinetic parameters of T1-weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) are considered to be largely influenced by microvessel environment. This study was performed to explore the extent of this association for meningiomas. MATERIALS AND METHODS: DCE-MRI kinetic parameters (contrast agent transfer constants Ktrans and kep, volume fractions vp and ve) were determined in pre-operative 3T MRI of meningioma patients for later biopsy sites (19 patients; 15 WHO I, no previous radiation, and 4 WHO III pre-radiated recurrent tumors)...
February 1, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29408592/stereotactic-radiofrequency-thermocoagulation-of-hypothalamic-hamartoma-using-robotic-guidance-rosa-co-registered-with-o-arm-guidance-preliminary-technical-note
#11
Vivek Tandon, Poodipedi Sarat Chandra, Ramesh Sharanappa Doddamani, Heri Subianto, Jitin Bajaj, Ajay Garg, Manjari Tripathi
INTRODUCTION: Treatment options for hypothalamic hamartoma (HH) include microvascular surgery, stereotactic radiofrequency thermocoagulation (SRT), laser interstitial thermal therapy (LITT) or Gamma knife surgery (GKS). During SRT, thermographic monitoring cannot be performed and therefore highly accurate placement of electrode and confirmation of its position are required. We have utilized robotic guidance (ROSA) and co-registered it with O-Arm, for performing ablation of hamartoma. METHODS: Five patients of HH with gelastic seizures (GS) underwent SRT...
February 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29405550/treatment-with-the-mitochondrial-targeted-antioxidant-peptide-ss-31-rescues-neurovascular-coupling-responses-and-cerebrovascular-endothelial-function-and-improves-cognition-in-aged-mice
#12
Stefano Tarantini, Noa M Valcarcel-Ares, Andriy Yabluchanskiy, Gabor A Fulop, Peter Hertelendy, Tripti Gautam, Eszter Farkas, Aleksandra Perz, Peter S Rabinovitch, William E Sonntag, Anna Csiszar, Zoltan Ungvari
Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to age-related decline of higher cortical functions. There is increasing evidence showing that mitochondrial oxidative stress plays a critical role in a range of age-related cellular impairments, but its role in neurovascular uncoupling remains unexplored...
February 6, 2018: Aging Cell
https://www.readbyqxmd.com/read/29404244/skull-base-reconstruction-in-the-pediatric-patient
#13
REVIEW
Irit Duek, Alon Pener-Tessler, Ravit Yanko-Arzi, Arik Zaretski, Avraham Abergel, Ahmad Safadi, Dan M Fliss
Introduction  Pediatric skull base and craniofacial reconstruction presents a unique challenge since the potential benefits of therapy must be balanced against the cumulative impact of multimodality treatment on craniofacial growth, donor-site morbidity, and the potential for serious psychosocial issues. Objectives  To suggest an algorithm for skull base reconstruction in children and adolescents after tumor resection. Materials and Methods  Comprehensive literature review and summary of our experience...
February 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29395640/disseminated-microinfarctions-with-cerebral-microbleeds
#14
Mark Fisher, Kevin Kapur, Sylvia Soo, Yung Lyou, Steven S Schreiber, Michael J Kim
Disseminated microinfarctions are uncommonly encountered in clinical practice. Here we describe a patient with long-standing cerebral microbleeds who developed acute cognitive decline in the setting of acute hypotension. Magnetic resonance imaging showed acute disseminated microinfarctions, with no change in microbleeds. This case emphasizes the important relationship between ischemic and hemorrhagic microvascular disease of the brain, especially in the setting of acute blood pressure changes compounding preexisting microvascular injury...
January 25, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29392628/prolonged-dipyridamole-administration-reduces-myocardial-perfusion-defects-in-experimental-chronic-chagas-cardiomyopathy
#15
Denise Mayumi Tanaka, Luciano Fonseca Lemos de Oliveira, José Antônio Marin-Neto, Minna Moreira Dias Romano, Eduardo Elias Vieira de Carvalho, Antonio Carlos Leite de Barros Filho, Fernando Fonseca França Ribeiro, Jorge Mejia Cabeza, Carla Duque Lopes, Camila Godoy Fabricio, Norival Kesper, Henrique Turin Moreira, Lauro Wichert-Ana, André Schmidt, Maria de Lourdes Higuchi, Edécio Cunha-Neto, Marcus Vinícius Simões
BACKGROUND: Myocardial perfusion defects (MPD) due to coronary microvascular dysfunction is frequent in chronic Chagas cardiomyopathy (CCC) and may be involved with development of myocardial damage. We investigated whether MPD precedes left ventricular systolic dysfunction and tested the hypothesis that prolonged use of dipyridamole (DIPY) could reduce MPD in an experimental model of CCC in hamsters. METHODS AND RESULTS: We investigated female hamsters 6-months after T...
February 1, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29392502/mosaic-capillaroscopic-findings-in-systemic-sclerosis
#16
Sevdalina Nikolova Lambova, Ulf Müller-Ladner
A 67-year-old woman with triphasic Raynaud's phenomenon since 2 years was diagnosed as having limited cutaneous systemic sclerosis (SSc) 1 year ago based on puffy fingers, positive antinuclear and anti-Scl-70 autoantibodies, and initial pulmonary fibrosis. Capillaroscopic examination revealed "mosaic" capillaroscopic findings that included normal pattern; "scleroderma"-type capillaroscopic pattern "early" phase, with single giant capillaries and haemorrhages, preserved capillary distribution; and "scleroderma"-type capillaroscopic pattern "active" phase, with high number of giant capillary loops and haemorrhages, moderately disturbed distribution...
February 1, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29392365/adc-similarity-predicts-microvascular-invasion-of-bifocal-hepatocellular-carcinoma
#17
Chun Yang, Heqing Wang, Yibo Tang, Shengxiang Rao, Ruofan Sheng, Yuan Ji, Mengsu Zeng
PURPOSE: This study aimed to investigate whether ADC similarity can predict microvascular invasion (MVI) in patients with bifocal hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Between January 2015 and September 2015, 51 patients with two HCC lesions were included. All patients underwent conventional magnetic resonance imaging including diffusion-weighted imaging (DWI) before the HCC lesions were surgically resected; the tumor specimens were examined histopathologically...
February 1, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29391150/microvascular-responsiveness-to-pulsatile-and-non-pulsatile-flow-during-cardiopulmonary-bypass
#18
Michael P O'Neil, Rene Alie, Linrui Ray Guo, Mary-Lee Myers, John Murkin, Chris Ellis
BACKGROUND: Pulsatile perfusion may offer microcirculatory advantages over conventional non-pulsatile perfusion during cardiopulmonary bypass (CPB). Here we present direct visual evidence of microvascular perfusion and vasoreactivity between perfusion modalities. METHODS: A prospective, randomized cohort study of twenty high-risk cardiac surgical patients undergoing pulsatile (n=10) or non-pulsatile (n=10) flow during CPB. Changes in sublingual mucosal microcirculation were assessed using orthogonal polarization spectral imaging along with near-infrared spectroscopic indices of thenar muscle tissue oxygen saturation (StO2) and its recovery during a vascular occlusion test at various time points: T0-baseline, T1-30min CPB, T2-90min CPB, T3-1hr post CPB, and T4-24hr post CPB...
January 29, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29383555/superb-microvascular-imaging-smi-findings-of-splenic-artery-pseudoaneurysm-a-report-of-two-cases
#19
Yumiko Yamanaka, Hideaki Ishida, Hiroko Naganuma, Tomoya Komatsuda, Hideaki Miyazawa, Takaharu Miyauchi, Satoshi Takahashi, Tomoki Tozawa, Katsuhiko Enomoto
Splenic artery pseudoaneurysm (SAPA) is a relatively infrequently encountered but clinically important vascular change, because it carries a high risk of rupture that warrants prompt treatment regardless of its size. Thus, sufficient knowledge is indispensable when seeing chronic pancreatitis patients or post-traumatic patients. Here, we report two such cases. The first case was a 52-year-old woman known to have chronic pancreatitis who presented with hematemesis and hemodynamic instability in which X-ray computed tomography (CT) and color Doppler sonography (CDS) had difficulty visualizing slow blood flow in SAPA, but superb microvascular imaging (SMI) clearly demonstrated the slow blood flow in SAPA, prompting our therapeutic decision to perform rapid embolization...
January 30, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29382844/deciphering-microvascular-changes-after-myocardial-infarction-through-3d-fully-automated-image-analysis
#20
Polyxeni Gkontra, Kerri-Ann Norton, Magdalena M Żak, Cristina Clemente, Jaume Agüero, Borja Ibáñez, Andrés Santos, Aleksander S Popel, Alicia G Arroyo
The microvasculature continuously adapts in response to pathophysiological conditions to meet tissue demands. Quantitative assessment of the dynamic changes in the coronary microvasculature is therefore crucial in enhancing our knowledge regarding the impact of cardiovascular diseases in tissue perfusion and in developing efficient angiotherapies. Using confocal microscopy and thick tissue sections, we developed a 3D fully automated pipeline that allows to precisely reconstruct the microvasculature and to extract parameters that quantify all its major features, its relation to smooth muscle actin positive cells and capillary diffusion regions...
January 30, 2018: Scientific Reports
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