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https://www.readbyqxmd.com/read/28749618/radiation-induced-second-cancer-risk-from-external-beam-photon-radiotherapy-for-head-and-neck-cancer-impact-on-in-field-and-out-of-field-organs
#1
Vasanthan Sakthivel, Ganesh Kadirampatti Mani, Sunil Mani, Raghavendiran Boopathy
The purpose of this paper is to provide data on development of second primary cancers within or adjacent to tissue irradiated in the treatment of primary head and neck cancers using different techniques and modalities. Materials and methods: We selected five patients with HandN tumors located in base of the tongue for risk assessment. In order to examine the impact of choices of various planning techniques, numbers of beams and beam energy used in treatment plans - 7 and 9 field Intensity modulated radiotherapy (IMRT) plans using 6MV and 10 MV beam energies and a 6MV Volumetric modulated arc therapy (VMAT) plans were planned...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749609/ricochet-pollination-in-senna-fabaceae-petals-deflect-pollen-jets-and-promote-division-of-labour-among-flower-organs
#2
Thiago Amorim, Brigitte Marazzi, Arlete A Soares, Eliana R Forni-Martins, Celli R Muniz, Christian Westerkamp
Naturalists Fritz and Hermann Müller hypothesised that heteranthery often leads to a division of labour into 'feeding' and 'pollinating' stamens; the latter often being as long as the pistil so as to promote successful pollination on the bees' back. In many buzz-pollinated species of Senna, however, the so-called pollinating stamens are short and do not level with the stigma, raising the question of how pollen is shed on the bees' back. Here we explore a mechanism called "ricochet pollination". We test whether division of labour is achieved through the interaction between short lower stamens and strongly concave "deflector petals"...
July 27, 2017: Plant Biology
https://www.readbyqxmd.com/read/28749595/morbidity-and-mortality-in-infant-mountain-gorillas-gorilla-beringei-beringei-a-46-year-retrospective-review
#3
James M Hassell, Dawn Zimmerman, Michael R Cranfield, Kirsten Gilardi, Antoine Mudakikwa, Jan Ramer, Elisabeth Nyirakaragire, Linda J Lowenstine
Long-term studies of morbidity and mortality in free-ranging primates are scarce, but may have important implications for the conservation of extant populations. Infants comprise a particularly important age group, as variation in survival rates may have a strong influence on population dynamics. Since 1968, the Mountain Gorilla Veterinary Project (MGVP, Inc.) and government partners have conducted a comprehensive health monitoring and disease investigation program on mountain gorillas (Gorilla beringei beringei) in Rwanda, Uganda, and the Democratic Republic of the Congo...
July 27, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28749533/charmm-force-field-and-molecular-dynamics-simulations-of-protonated-polyethylenimine
#4
Titus Adrian Beu, Alexandra Farcaş
As a gene delivery vector, polyethylenimine (PEI) shows one of the highest transfection efficiencies, while effectively protecting DNA from enzyme degradation. The distinctive charge pattern of protonated PEI is widely considered responsible for fundamental process such as DNA condensation into PEI/DNA polyplexes (which are able to enter cells via endocytosis), proton sponge effect (which triggers the release of polyplexes from endosome), and release of DNA from polyplexes (to be further processed inside the nucleus)...
July 27, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28749412/multi-targeting-andrographolide-a-novel-nf-%C3%AE%C2%BAb-inhibitor-as-a-potential-therapeutic-agent-for-stroke
#5
REVIEW
Chih-Hao Yang, Ting-Lin Yen, Chia-Yuan Hsu, Philip-Aloysius Thomas, Joen-Rong Sheu, Thanasekaran Jayakumar
A key focus in the field of drug discovery has been motivated by the neuroprotection of natural compounds. Cerebral ischemia is a multifaceted pathological process with a series of mechanisms, and a perspective for the development of neuroprotectants from traditional herbal medicine or natural products is a promising treatment for this disease. Natural compounds with the effects of anti-oxidation, anti-inflammation, anti-apoptosis, and neurofunctional regulation exhibit therapeutic effects on experimental ischemic brain injury...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749376/ag-nanoparticles-decorated-molybdenum-oxide-structures-growth-characterizations-dft-studies-and-their-application-for-enhanced-field-emission
#6
Puspendu Guha, Arnab Ghosh, Ranjit Thapa, E Mathan Kumar, Sabarikirishwaran Ponnambalam, Ranveer Singh, Parlapalli V Satyam
We report a simple single step growth of α-MoO<sub>3</sub> structures and energetically suitable site specific Ag nanoparticles (NPs) decorated α-MoO<sub>3</sub> structures on varied substrates, having almost similar morphologies and oxygen vacancies. We have elucidated possible growth mechanism in the light of experimental findings and density functional theoretical (DFT) calculations. We have experimentally established and verified by DFT calculations that MoO<sub>3</sub>(010) surface as weakly interacting and stable surface compared to other orientations...
July 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28749375/towards-fast-online-intrafraction-replanning-for-free-breathing-stereotactic-body-radiation-therapy-with-the-mr-linac
#7
Charis Kontaxis, Gijsbert H Bol, Bjorn Stemkens, Markus Glitzner, Fieke M Prins, Linda G W Kerkmeijer, Jan J W Lagendijk, Bas W Raaymakers
The hybrid MRI-radiotherapy machines, like the MR-linac (Elekta AB, Stockholm, Sweden) installed at the UMC Utrecht (Utrecht, The Netherlands), will be able to provide real-time patient imaging during treatment. In order to take advantage of the system's capabilities and enable online adaptive treatments, a new generation of software should be developed, ranging from motion estimation to treatment plan adaptation. In this work we present a proof of principle adaptive pipeline designed for high precision Stereotactic Body Radiation Therapy (SBRT) suitable for sites affected by respiratory motion, like Renal Cell Carcinoma (RCC)...
July 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28749348/fast-simulation-of-dynamic-ultrasound-images-using-the-gpu
#8
Sigurd Storve, Hans Torp
Simulated ultrasound data is a valuable tool for development and validation of quantitative image analysis methods in echocardiography. Unfortunately, simulation time can become prohibitive for phantoms consisting of a large number of point-scatterers. The COLE algorithm by Gao et al. is a fast convolution-based simulator that trades simulation accuracy for improved speed. We present highly efficient parallelized CPU- and GPU-implementations of the COLE algorithm with an emphasis on dynamic simulations involving moving pointscatterers...
July 25, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28749308/evaluation-of-the-effects-of-sternal-versus-lateral-recumbency-on-trends-of-selected-physiologic-parameters-during-isoflurane-anesthesia-in-zoo-housed-black-tailed-prairie-dogs-cynomys-ludovicianus
#9
David Eshar, Diane Mason, Nili Avni-Magen, Elizabeth Kaufman, Avital Paz, Hugues Beaufrère
Isoflurane gas anesthesia is often used for immobilization of prairie dogs in field studies, laboratory research, and veterinary clinical purposes. The goals of this prospective study were to evaluate the effects of sternal versus right lateral recumbency on trends of selected physiologic parameters during isoflurane anesthesia in black-tailed prairie dogs ( Cynomys ludovicianus ). Fourteen adult, zoo-housed black-tailed prairie dogs were tested during the study. Animals were anesthetized using isoflurane and randomly placed in either sternal or right lateral recumbency to evaluate changes in trends of physiologic parameters, measured selectively every 30 min throughout a 60-min anesthesia period...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749160/the-unfolding-impact-of-leader-identity-entrepreneurship-on-burnout-work-engagement-and-turnover-intentions
#10
Niklas K Steffens, Jie Yang, Jolanda Jetten, S Alexander Haslam, Jukka Lipponen
The present research expands upon previous theory and empirical work concerning the leadership-health link by examining the lagged effects of leader identity entrepreneurship (i.e., leaders' creation of a sense of "we" and "us" among team members) on team members' burnout, work engagementi and turnover intentions. We report results from a 2-wave field study with employees from a large solar panel producing organization in China conducted over a 10-month period. Findings indicate that perceived leader identity entrepreneurship predicted greater subsequent work engagement among team members, as well as lower subsequent burnout and turnover intentions...
July 27, 2017: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/28749152/when-fellow-customers-behave-badly-witness-reactions-to-employee-mistreatment-by-customers
#11
M Sandy Hershcovis, Namita Bhatnagar
In 3 experiments, we examined how customers react after witnessing a fellow customer mistreat an employee. Drawing on the deontic model of justice, we argue that customer mistreatment of employees leads witnesses (i.e., other customers) to leave larger tips, engage in supportive employee-directed behaviors, and evaluate employees more positively (Studies 1 and 2). We also theorize that witnesses develop less positive treatment intentions and more negative retaliatory intentions toward perpetrators, with anger and empathy acting as parallel mediators of our perpetrator- and target-directed outcomes, respectively...
July 27, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28749151/on-the-boundary-conditions-of-effort-losses-and-effort-gains-in-action-teams
#12
Joachim Hüffmeier, Michael Filusch, Jens Mazei, Guido Hertel, Andreas Mojzisch, Stefan Krumm
While people's willingness to work hard can be reduced in teams (i.e., effort losses in teams as compared with individual work), it is less recognized that teamwork can also stimulate additional efforts (i.e., effort gains). Building on and extending existing theory, we (a) suggest an integration of these two research streams, and (b) provide evidence for team-related effort gains in action teams. In a first study, we tested our predictions by reanalyzing a field data set of 302,576 swimming performances in individual and relay races (Neugart & Richiardi, 2013)...
July 27, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28749150/positive-and-negative-assessment-center-feedback-in-relation-to-development-self-efficacy-feedback-seeking-and-promotion
#13
Nikolaos Dimotakis, Deb Mitchell, Todd Maurer
In this field study we examined both positive and negative developmental feedback given in managerial assessment centers in relation to employees' self-efficacy for their ability to improve their relevant skills assessed in the centers, the extent to which they sought subsequent feedback from others at work, and the career outcome of being promoted to a higher level position within the organization. We found that feedback was related to self-efficacy for improvement which was in turn positively related to feedback seeking, which was positively linked to the career outcome of promotion (e...
July 27, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28749127/fuzzy-c-means-clustering-based-segmentation-and-cnn-classification-for-accurate-segmentation-of-lung-nodules
#14
Jalal Deen K, Ganesan R, Merline A
Objective: Accurate segmentation of abnormal and healthy lungs is very crucial for a steadfast computer-aided disease diagnostics. Methods: For this purpose a stack of chest CT scans are processed. In this paper, novel methods are proposed for segmentation of the multimodal grayscale lung CT scan. In the conventional methods using Markov–Gibbs Random Field (MGRF) model the required regions of interest (ROI) are identified. Result: The results of proposed FCM and CNN based process are compared with the results obtained from the conventional method using MGRF model...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749058/conservationism-and-bioethic
#15
EDITORIAL
Gregory E Kaebnick
The lead article in this issue of the Hastings Center Report (July-August 2017) explores the ideas underpinning the Precision Medicine Initiative, the effort announced by President Obama in 2015 to promote the development of treatments adjusted to genetic and other variations. Authors Maya Sabatello and Paul Appelbaum hold that the effort works by appealing to a sense of collective identity and shared commitment-an understanding that they call the "PMI nation." But what are the moral implications of this idea? Sabatello and Appelbaum's question about the impact of an imagined community is an unusual way of exploring a set of values questions...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28749013/physiological-versus-pharmacological-signalling-to-myosin-phosphorylation-in-airway-smooth-muscle
#16
Ning Gao, Ming-Ho Tsai, Audrey N Chang, Weiqi He, Cai-Ping Chen, Minsheng Zhu, Kristine E Kamm, James T Stull
Ca(2+) /calmodulin activation of myosin light chain kinase (MLCK) initiates myosin regulatory light chain (RLC) phosphorylation for smooth muscle contraction with subsequent dephosphorylation for relaxation by myosin light chain phosphatase (MLCP) containing regulatory (MYPT1) and catalytic (PP1cδ) subunits. RLC phosphorylation-dependent force development is regulated by distinct signalling modules involving protein phosphorylations. We investigated responses to cholinergic agonist treatment versus neurostimulation by electric field stimulation (EFS) in bovine tracheal smooth muscle...
July 27, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28748996/clinical-applications-of-pharmacogenomics
#17
Luis Quiñones, Ángela Roco, Juan P Cayún, Paula Escalante, Carla Miranda, Nelson Varela, Francisca Meneses, Bastián Gallegos, Fausto Zaruma-Torres, Ismael Lares-Asseff
Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748831/investigation-of-the-superconducting-gap-structure-in-%C3%AE%C2%BA-bedt-ttf-sub-2-sub-cu-ncs-sub-2-sub-and-%C3%AE%C2%BA-bedt-ttf-sub-2-sub-cu-n-cn-sub-2-sub-br-by-means-of-thermal-conductivity-measurements
#18
Sebastian Kühlmorgen, Rico Schönemann, Elizabeth Lauren Green, Jens Mueller, J Wosnitza
We report temperature-dependent thermal-conductivity, <i>κ</i>, measurements on the layered quasi-two-dimensional organic superconductors κ-(BEDT-TTF)<sub>2</sub>Cu(NCS)<sub>2</sub> and κ-(BEDT-TTF)<sub>2</sub>Cu[N(CN)<sub>2</sub>]Br down to 160 mK. The results for κ-(BEDT-TTF)<sub>2</sub>Cu(NCS)<sub>2</sub> may be consistent with a nodal superconducting (SC) gap structure as indicated by a non-negligible remnant linear contribution when <i>κ/T →T^2</i> is extrapolated to <i>T = 0</i>...
July 27, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28748770/management-of-diabetic-surgical-patients-in-a-deployed-field-hospital-a-model-for-acute-non-communicable-disease-care-in-disaster
#19
Kathleen M McDermott, Ruth M Hardstaff, Sophie Alpen, David J Read, Nicholas R Coatsworth
Sudden onset disasters (SODs) have affected over 1.5 billion of the world's population in the past decade. During the same time, developing nations have faced a sustained increase in the burden of non-communicable disease (NCD) with extra pressure placed on health systems. The combined increase in SODs and the NCD epidemic facing the world's most disaster-prone nations will present new challenges to emergency medical teams (EMTs) during disaster response. This report details the experience as an EMT during the Typhoon Haiyan disaster of 2013, with particular reference to the challenges of diabetic management in a surgical field hospital...
July 27, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28748729/a-categorical-content-analysis-of-highly-cited-literature-related-to-trends-and-issues-in-special-education
#20
Sarah V Arden, Jill M Pentimonti, Rochana Cooray, Stephanie Jackson
This investigation employs categorical content analysis processes as a mechanism to examine trends and issues in a sampling of highly cited (100+) literature in special education journals. The authors had two goals: (a) broadly identifying trends across publication type, content area, and methodology and (b) specifically identifying articles with disaggregated outcomes for students with learning disabilities (LD). Content analyses were conducted across highly cited (100+) articles published during a 20-year period (1992-2013) in a sample ( n = 3) of journals focused primarily on LD, and in one broad, cross-categorical journal recognized for its impact in the field...
July 1, 2017: Journal of Learning Disabilities
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