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https://www.readbyqxmd.com/read/29786969/hippocampal-lipidome-and-transcriptome-profile-alterations-triggered-by-acute-exposure-of-mice-to-gsm-1800-mhz-mobile-phone-radiation-an-exploratory-study
#1
Adamantia F Fragopoulou, Alexandros Polyzos, Maria-Despoina Papadopoulou, Anna Sansone, Areti K Manta, Evangelos Balafas, Nikolaos Kostomitsopoulos, Aikaterini Skouroliakou, Chryssostomos Chatgilialoglu, Alexandros Georgakilas, Dimitrios J Stravopodis, Carla Ferreri, Dimitris Thanos, Lukas H Margaritis
BACKGROUND: The widespread use of wireless devices during the last decades is raising concerns about adverse health effects of the radiofrequency electromagnetic radiation (RF-EMR) emitted from these devices. Recent research is focusing on unraveling the underlying mechanisms of RF-EMR and potential cellular targets. The "omics" high-throughput approaches are powerful tools to investigate the global effects of RF-EMR on cellular physiology. METHODS: In this work, C57BL/6 adult male mice were whole-body exposed (nE xp  = 8) for 2 hr to GSM 1800 MHz mobile phone radiation at an average electric field intensity range of 4...
May 22, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29786939/an-update-on-enzymatic-cocktails-for-lignocellulose-breakdown
#2
REVIEW
Andreza de Mello Lopes, Edivaldo Ximenes Ferreira Filho, Leonora Rios de Souza Moreira
Alternative energy sources have received increasing attention in recent years. The possibility of adding value to agricultural wastes, by producing biofuels and other products with economic value from lignocellulosic biomass by enzymatic hydrolysis, has been widely explored. Lignocellulosic biomass, as well as being an abundant residue, is a complex recalcitrant structure that requires a consortium of enzymes for its complete degradation. Pools of enzymes with different specificities acting together usually produce an increase in hydrolysis yield...
May 22, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29786842/correlated-time-variation-of-bulk-microstructure-and-rheology-in-asphalt-binders
#3
A Ramm, N Sakib, A Bhasin, M C Downer
We use near-infrared dark-field optical microscopy to probe isothermal time variation of the volume fraction of naturally-occurring, subsurface microstructures in PG 64-22 asphalt binders at temperature T=30∘C, following a rapid heating (cooling) increment |ΔT|=20∘C from initial temperature T0=10∘C(50∘C). We compare these microstructure variations with isothermal time variations of the magnitude |G30∗(t)| of the bulk complex shear modulus measured for identical sample conditions with a Dynamic Shear Rheometer...
May 22, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29786805/-classification-of-seizures-and-epilepsies
#4
Johan Zelano, Tommy Stödberg, Torbjörn Tomson
In 2017 the International League Against Epilepsy (ILAE) published position papers outlining new classifications of seizures and epilepsies. The aims of the new documents are to encompass advances in the field, provide a conceptual framework for future developments, and facilitate communication. In practice, the terminology is somewhat revised. For seizures the terms "partial" and "simple/complex" are replaced by "focal" and "aware/impaired awareness". The classification of a patient's epilepsy is based on seizures types (e...
May 21, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29786798/studies-on-steroid-receptor-coactivators-in-prostate-cancer
#5
Zoran Culig, Frédéric R Santer
High expression of several androgen receptor coactivators is frequently reported in prostate cancer. Coactivators such as p300/CBP are involved in modulation of androgen receptor activity by increasing the effects of androgenic hormones and enhancing agonistic activity of antiandrogens. Studies in the field of prostate cancer frequently examined the role of p300/CBP and SRC-1 (NCOA1). In addition to their effects on steroid receptor activity, coactivators may influence other cellular functions such as migration and invasion...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29786775/stormram-4-an-mr-safe-robotic-system-for-breast-biopsy
#6
Vincent Groenhuis, Françoise J Siepel, Jeroen Veltman, Jordy K van Zandwijk, Stefano Stramigioli
Suspicious lesions in the breast that are only visible on magnetic resonance imaging (MRI) need to be biopsied under MR guidance with high accuracy and efficiency for accurate diagnosis. The aim of this study is to present a novel robotic system, the Stormram 4, and to perform preclinical tests in an MRI environment. Excluding racks and needle, its dimensions are 72 × 51 × 40 mm. The Stormram 4 is driven by two linear and two curved pneumatic stepper motors. The linear motor is capable of exerting 63 N of force at a pressure of 0...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786774/computational-fluid-dynamics-modeling-of-the-human-pulmonary-arteries-with-experimental-validation
#7
Alifer D Bordones, Matthew Leroux, Vitaly O Kheyfets, Yu-An Wu, Chia-Yuan Chen, Ender A Finol
Pulmonary hypertension (PH) is a chronic progressive disease characterized by elevated pulmonary arterial pressure, caused by an increase in pulmonary arterial impedance. Computational fluid dynamics (CFD) can be used to identify metrics representative of the stage of PH disease. However, experimental validation of CFD models is often not pursued due to the geometric complexity of the model or uncertainties in the reproduction of the required flow conditions. The goal of this work is to validate experimentally a CFD model of a pulmonary artery phantom using a particle image velocimetry (PIV) technique...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786757/copy-number-abnormality-of-acute-lymphoblastic-leukemia-cell-lines-based-on-their-genetic-subtypes
#8
Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi, Takeshi Inukai, Kanji Sugita, Hajime Hosoi
In this study, we performed genetic analysis of 83 B cell precursor acute lymphoblastic leukemia (B-ALL) cell lines. First, we performed multiplex ligation-dependent probe amplification analysis to identify copy number abnormalities (CNAs) in eight genes associated with B-ALL according to genetic subtype. In Ph+ B-ALL cell lines, the frequencies of IKZF1, CDKN2A/2B, BTG1, and PAX5 deletion were significantly higher than those in Ph- B-ALL cell lines. The frequency of CDKN2A/2B deletion in KMT2A rearranged cell lines was significantly lower than that in non-KMT2A rearranged cell lines...
May 21, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29786740/shear-density-coupling-for-a-compressible-single-component-yield-stress-fluid
#9
Markus Gross, Fathollah Varnik
Flow behavior of a single-component yield stress fluid is addressed on the hydrodynamic level. A basic ingredient of the model is a coupling between fluctuations of density and velocity gradient via a Herschel-Bulkley-type constitutive model. Focusing on the limit of low shear rates and high densities, the model approximates well-but is not limited to-gently sheared hard sphere colloidal glasses, where solvent effects are negligible. A detailed analysis of the linearized hydrodynamic equations for fluctuations and the resulting cubic dispersion relation reveals the existence of a range of densities and shear rates with growing flow heterogeneity...
May 22, 2018: Soft Matter
https://www.readbyqxmd.com/read/29786727/rational-design-of-multi-functional-gold-nanoparticles-with-controlled-biomolecule-adsorption-a-multi-method-approach-for-in-depth-characterization
#10
Isaac Ojea-Jiménez, Robin Capomaccio, Inês Osório, Dora Mehn, Giacomo Ceccone, Rohanah Hussain, Giuliano Siligardi, Pascal Colpo, François Rossi, Douglas Gilliland, Luigi Calzolai
Multi-functionalized nanoparticles are of great interest in biotechnology and biomedicine, especially for diagnostic and therapeutic purposes. However, at the moment the characterization of complex, multi-functional nanoparticles is still challenging and this hampers the development of advanced nanomaterials for biological applications. In this work, we have designed a model system consisting of gold nanoparticles functionalized with two differentially-terminated poly(ethylene oxide) ligands, providing both "stealth" properties and protein-binding capabilities to the nanoparticles...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786723/a-highly-sensitive-and-fast-graphene-nanoribbon-cspbbr-3-quantum-dot-phototransistor-with-enhanced-vertical-metal-oxide-heterostructures
#11
Xiang Liu, Wenjian Kuang, Haibing Ni, Zhi Tao, Qianqian Huang, Jing Chen, Qingquan Liu, Jianhua Chang, Wei Lei
Although recent breakthroughs in reported graphene-based phototransistors with embedded quantum dots (QDs) have definitely been astonishing, there are still some obstacles in their practical use with regard to their electrical and optical performances. We show that through optimization of the vertical graphene nanoribbon (GNR)/QD/IGZO heterostructure and the ultrahigh efficiency of CsPbBr3 QDs, it is possible to significantly increase the on/off ratio (>103), the subthreshold slope (S.S., 0.9 V dec-1), the device's field effect mobility (μFET, 13 cm-1 V-1 S-1) and other electrical properties...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786716/unexpected-protonation-state-of-glu197-discovered-from-simulations-of-tacrine-in-butyrylcholinesterase
#12
Xiao Wan, Yuan Yao, Lei Fang, Junjun Liu
Butyrylcholinesterase (BChE) has been actively involved in drug discoveries from many fields for decades. In the crystal structure of the BChE-tacrine complex, there is an unanticipated formyl-proline molecule resolved very close to tacrine, raising an essential question on how reliable it is to apply the binding pose in a crystal structure to analyze related experimental observations, in which no formyl-proline is actually involved. In this study, by performing a series of 100 ns molecular dynamics simulations, we demonstrate that it is safe to employ the structural information from this crystal structure to analyze related experimental observations...
May 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29786708/platforms-for-rapid-cancer-characterization-by-ambient-mass-spectrometry-advancements-challenges-and-opportunities-for-improvement-towards-intrasurgical-use
#13
Michael Woolman, Arash Zarrine-Afsar
Ambient Mass Spectrometry (MS) analysis is widely used to characterize biological and non-biological samples. Advancements that allow rapid analysis of samples by ambient methods such as Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) and Rapid Evaporative Ionization Mass Spectrometry (REIMS) are discussed. A short, non-comprehensive overview of ambient MS is provided that only contains example applications due to space limitations. A spatially encoded mass spectrometry analysis concept to plan cancer resection is introduced...
May 22, 2018: Analyst
https://www.readbyqxmd.com/read/29786704/peri-implant-tissue-score-pits-as-a-measure-of-success-applied-to-869-dental-implants-from-a-retrospective-clinical-study
#14
Zbyněk Mazur, Ladislav Korábek, Daniel Mazur
OBJECTIVE: This article presents a methodology of a comprehensive score for assessment and monitoring of dental implant success from the peri-implant tissue perspective. It involves only standard and minimally invasive techniques accessible to general dental practices, without the need for special equipment. METHODS AND MATERIALS: The proposed score methodology combines existing consensual global knowledge regarding aspects of dental implant success with the standard examination tools accepted for regular recall assessment...
May 17, 2018: Quintessence International
https://www.readbyqxmd.com/read/29786681/-the-role-of-changes-in-the-structure-of-water-and-water-based-systems-in-the-mechanism-of-combined-action-of-the-magnetic-field-and-natural-therapeutic-factors
#15
E F Levitsky, B I Laptev, G N Sidorenko, T G Ivanova, N P Gorlenko, L V Antoshkin
The application of the dielectrometric technology in the combination with the resonance method and thermometry has been shown to provide an insight into a variety of factors including the influence of the magnetic field of the permanent magnets on the structure of water and water-containing systems. It was found that the magnetization of both distilled water and «Karachinskaya» mineral water increase their structuredness. Magnetization changes the biological properties of therapeutic peloids by virtue of a change in the structure of water and, accordingly, the structuring of the water fraction of therapeutic muds...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29786679/-the-rationale-for-the-application-of-photomagnetic-therapy-in-the-treatment-of-dermatitis
#16
N I Schastnaya, V S Ulashchyk
BACKGROUND: in spite of the fact that photomagnetic therapy with the use of the FotoSPOK device (Magnomed Ltd., Belarus) is already used in the medical practice, the application of this method for the management of many diseases remains to be substantiated on the scientifically sound grounds. AIM: The objective of the present study was to evaluate the effectiveness of photomagnetic therapy in the treatment of the local inflammatory process in the skin and to elaborate the rationale for the application of this technique in the treatment of contact dermatitis...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29786673/fabrication-flexible-and-luminescent-nanofibrillated-cellulose-films-with-modified-sral%C3%A2-o%C3%A2-eu-dy-phosphors-via-nanoscale-silica-and-aminosilane
#17
Longfei Zhang, Shaoyi Lyu, Zhilin Chen, Siqun Wang
Flexible 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized nanofibrillated cellulose (ONFC) films with long afterglow luminescence containing modified SrAl₂O₄: Eu2+ , Dy3+ (SAOED) phosphors were fabricated by a template method. Tetraethyl orthosilicate (TEOS) and (3-aminopropyl) trimethoxy-silane (APTMS) were employed cooperatively to improve the water resistance and compatibility of the SAOED particles in the ONFC suspension. The structure and morphology after modification evidenced the formation of a superior SiO₂ layer and coarse amino-compounds on the surface of the phosphors...
May 22, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29786665/automated-field-of-view-illumination-and-recognition-algorithm-design-of-a-vision-system-for-pick-and-place-considering-colour-information-in-illumination-and-images
#18
Yibing Chen, Taiki Ogata, Tsuyoshi Ueyama, Toshiyuki Takada, Jun Ota
Machine vision is playing an increasingly important role in industrial applications, and the automated design of image recognition systems has been a subject of intense research. This study has proposed a system for automatically designing the field-of-view (FOV) of a camera, the illumination strength and the parameters in a recognition algorithm. We formulated the design problem as an optimisation problem and used an experiment based on a hierarchical algorithm to solve it. The evaluation experiments using translucent plastics objects showed that the use of the proposed system resulted in an effective solution with a wide FOV, recognition of all objects and 0...
May 22, 2018: Sensors
https://www.readbyqxmd.com/read/29786650/a-review-of-tunable-wavelength-selectivity-of-metamaterials-in-near-field-and-far-field-radiative-thermal-transport
#19
Yanpei Tian, Alok Ghanekar, Matt Ricci, Mikhail Hyde, Otto Gregory, Yi Zheng
Radiative thermal transport of metamaterials has begun to play a significant role in thermal science and has great engineering applications. When the key features of structures become comparable to the thermal wavelength at a particular temperature, a narrowband or wideband of wavelengths can be created or shifted in both the emission and reflection spectrum of nanoscale metamaterials. Due to the near-field effect, the phenomena of radiative wavelength selectivity become significant. These effects show strong promise for applications in thermophotovoltaic energy harvesting, nanoscale biosensing, and increased energy efficiency through radiative cooling in the near future...
May 22, 2018: Materials
https://www.readbyqxmd.com/read/29786644/impact-of-bone-fracture-on-ischemic-stroke-recovery
#20
REVIEW
Meng Wei, Haiyian Lyu, Kang Huo, Hua Su
Stroke is one of the most devastating complications of bone fracture, occurring in up to 4% of patients after surgical repair for hip fracture. Bone fracture and ischemic stroke have many common risk factors. The impact of bone fracture on stroke recovery has not drawn much attention in the research field. Bone fracture could occur in stroke patients at different times during the recovery phase, which steepens the trajectory of cognitive decline, greatly affects the quality of life, and causes a heavy burden on healthcare resources...
May 22, 2018: International Journal of Molecular Sciences
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