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https://www.readbyqxmd.com/read/29792980/language-used-by-health-care-professionals-to-describe-dying-at-an-acute-care-hospital
#1
Kirsten Wentlandt, Philippe Toupin, Natalia Novosedlik, Lisa W Le, Camilla Zimmermann, Ebru Kaya
PURPOSE: To understand the language used to describe the deterioration and death of patients in an acute academic tertiary care centre, and to identify whether patient diagnoses or palliative care(PC) involvement was associated with clearer descriptions of this process. METHODS: We conducted a retrospective chart review of the final admission of 150 patients who died on an inpatient internal medicine unit. Conventional and summative content analysis was performed of the language used to describe, either directly or indirectly, that the patient's death was imminent...
May 21, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29792979/immune-checkpoint-inhibitor-toxicity-review-for-the-palliative-care-clinician
#2
Eric D Hansen, Xiao Wang, Amy A Case, Igor Puzanov, Tom Smith
Immune checkpoint inhibitors (ICI) have opened an exciting chapter in the treatment of patients with advanced cancer. For the palliative care clinician, however, ICI present several new challenges, including new ways to define treatment success, as well as treatment-related toxicities which differ in nature and timing from traditional chemotherapy. In this article, we review the mechanism of action of immune checkpoint inhibitors, as well as selected published data supporting the efficacy of ICI in patients with advanced cancer...
May 21, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29792736/overutilization-of-health-care-resources-for-breast-pain
#3
Anne C Kushwaha, Kyungmin Shin, Megan Kalambo, Ravinder Legha, Karen E Gerlach, Megha Madhukar Kapoor, Wei T Yang
OBJECTIVE: The objective of this study is to analyze the incidence of women with breast pain who present to an imaging center and assess the imaging findings, outcomes, and workup costs at breast imaging centers affiliated with one institution. MATERIALS AND METHODS: Demographic characteristics of and imaging findings for female patients presenting with breast pain at three community breast imaging centers between January 1, 2014, and December 31, 2014, were reviewed...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792375/knowledge-and-attitudes-of-family-doctors-dermatologists-and-endocrinologists-on-sun-exposure-and-vitamin-d
#4
Arif Abu-Abed, Said Azbarga, Roni Peleg
OBJECTIVES: Vitamin D is an important component of bone metabolism. Skin cells synthesize vitamin D when exposed to the sun. However, prolonged sun exposure damages the skin and increases the risk for skin cancer. The objective is to evaluate and compare the attitudes and recommendations of family doctors, dermatologists, and endocrinologists on exposure to the sun and vitamin D. METHODS: In a cross-sectional study, a questionnaire was completed by personal interview in a study population of 78 family doctors, 21 dermatologists, and 22 endocrinologists...
May 24, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29792235/the-persons-score-for-symptoms-assessment-in-simultaneous-care-setting-a-pilot-study
#5
Alessio Cortellini, Giampiero Porzio, Eva K Masel, Anna S Berghoff, Barbara Knotzer, Alessandro Parisi, Francesco Pavese, Corrado Ficorella, Lucilla Verna
One of the first steps to early integrate palliative care into oncology practice is a timely and efficient evaluation of symptoms (Bakitas et al., 2015; Davis et al., 2015; Temel et al., 2010). In a recent position paper, the Italian Association of Medical Oncology tells oncologists that they "must be able to prevent, recognize, measure, and treat all cancer-related symptoms" (Zagonel et al., 2017). Major international scientific societies such as the American Society of Clinical Oncology and the European Society of Medical Oncology have often defined the key role of symptoms evaluation and management to force the integration of palliative care into oncology (Davis et al...
May 24, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29792232/effect-of-postoperative-goal-directed-therapy-in-cancer-patients-undergoing-high-risk-surgery-a-randomized-clinical-trial-and-meta-analysis
#6
Aline Rejane Muller Gerent, Juliano Pinheiro Almeida, Evgeny Fominskiy, Giovanni Landoni, Gisele Queiroz de Oliveira, Stephanie Itala Rizk, Julia Tizue Fukushima, Claudia Marques Simoes, Ulysses Ribeiro, Clarice Lee Park, Rosana Ely Nakamura, Rafael Alves Franco, Patricia Inês Cândido, Cintia Rosa Tavares, Ligia Camara, Graziela Dos Santos Rocha Ferreira, Elisangela Pinto Marinho de Almeida, Roberto Kalil Filho, Filomena Regina Barbosa Gomes Galas, Ludhmila Abrahão Hajjar
BACKGROUND: Perioperative goal-directed hemodynamic therapy (GDHT) has been advocated in high-risk patients undergoing noncardiac surgery to reduce postoperative morbidity and mortality. We hypothesized that using cardiac index (CI)-guided GDHT in the postoperative period for patients undergoing high-risk surgery for cancer treatment would reduce 30-day mortality and postoperative complications. METHODS: A randomized, parallel-group, superiority trial was performed in a tertiary oncology hospital...
May 23, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29792122/drug-cost-avoidance-in-clinical-trials-of-breast-cancer
#7
M Mañes-Sevilla, R Romero-Jiménez, A Herranz-Alonso, M Sánchez-Fresneda, E Gonzalez-Haba, R Collado-Borrel, J Benedi-González, M Sanjurjo-Sáez
Background The objectives of this study were to determine if clinical trials in breast cancer, with an investigational drug, created direct drug cost savings for the healthcare system related to cost avoidance of the best standard of care treatments used in these studies. The aim was to quantify this potential drug cost avoidance. Methods We conducted a retrospective observational study of the drug cost avoidance during the study period (2014-2016). We included clinical trials with investigational drug, managed by pharmacy department and provided by the sponsor...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29791941/understanding-refugees-health
#8
Martin Müller, Dana Khamis, David Srivastava, Aristomenis K Exadaktylos, Carmen Andrea Pfortmueller
According to the United Nations Refugee Agency (UNHCR), 65.6 million people have been forcibly displaced worldwide. Several factors have a major influence on asylum seekers' health; so, their health profile is markedly different from that of the population in the country of asylum. The aim of this study is to review the major issues physicians need to be aware of when treating asylum seekers, with a special focus on the neurological problems of asylum seekers and refugees. The major impact factors on refugees' health are linked to experiences and exposure (1) in the country of origin, (2) in refugee camps and en route to Europe, and (3) in the process of immigration into the host country and living in European asylum centers...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791891/transanal-endoscopic-microsurgery-with-or-without-completion-total-mesorectal-excision-for-t2-and-t3-rectal-carcinoma
#9
Jeroen W A Leijtens, Thomas W A Koedam, Wernard A A Borstlap, Monique Maas, Pascal G Doornebosch, Tom M Karsten, Eric J Derksen, Laurents P S Stassen, Camiel Rosman, Eelco J R de Graaf, André J A Bremers, Jeroen Heemskerk, Geerard L Beets, Jurriaan B Tuynman, Kevin L J Rademakers
AIM: Transanal endoscopic microsurgery (TEM) is used for the resection of large rectal adenomas and well or moderately differentiated T1 carcinomas. Due to difficulty in preoperative staging, final pathology may reveal a carcinoma not suitable for TEM. Although completion total mesorectal excision is considered standard of care in T2 or more invasive carcinomas, this completion surgery is not always performed. The purpose of this article is to evaluate the outcome of patients after TEM-only, when completion surgery would be indicated...
May 23, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29791832/rationale-opportunities-and-reality-of-biosimilar-medications
#10
Gary H Lyman, Robin Zon, R Donald Harvey, Richard L Schilsky
Biologic therapies for cancer and other disorders contribute to improved outcomes for many patients but also account for a large proportion of health care expenditures. Opportunities for cost containment may emerge as the patents on originator products expire and highly similar agents known as..
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791673/development-of-a-clinical-protocol-for-detection-of-cervical-cancer-precursor-lesions
#11
Deise Maria Do Nascimento Sousa, Ana Carolina Maria Araújo Chagas, Camila Teixeira Moreira Vasconcelos, Airton Tetelbom Stein, Mônica Oliveira Batista Oriá
OBJECTIVE: to develop and validate the content of a clinical protocol aimed at prevention of cervical cancer in primary care. METHOD: technological research according to the steps: (1) submission of the project to the research ethics committee; (2) bibliographic survey; (3) elaboration of the clinical protocol; and (4) content validation. In the third step, the information was collected through bibliographic research and gynecology specialists were consulted. For the final step, four judges were selected to evaluate the clinical protocol according to AGREE 2...
2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29791286/metastatic-pancreatic-cancer-asco-clinical-practice-guideline-update
#12
Davendra P S Sohal, Erin B Kennedy, Alok Khorana, Mehmet S Copur, Christopher H Crane, Ignacio Garrido-Laguna, Smitha Krishnamurthi, Cassadie Moravek, Eileen M O'Reilly, Philip A Philip, Ramesh K Ramanathan, Joseph T Ruggiero, Manish A Shah, Susan Urba, Hope E Uronis, Michelle W Lau, Daniel Laheru
Purpose In 2016, ASCO published a guideline to assist in clinical decision making in metastatic pancreatic cancer for initial assessment after diagnosis, first- and second-line treatment options, palliative and supportive care, and follow-up. The purpose of this update is to incorporate new evidence related to second-line therapy for patients who have experienced disease progression or intolerable toxicity during first-line therapy. Methods ASCO convened an Expert Panel to conduct a systematic review of the literature on second-line therapy published between June 2015 and January 2018...
May 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29791275/effects-of-web-based-instruction-and-patient-preferences-on-patient-reported-outcomes-and-learning-for-women-with-advanced-ovarian-cancer-a-randomized-controlled-trial
#13
Sue V Petzel, Rachel Isaksson Vogel, Julie Cragg, Molly McClellan, Daniel Chan, Julie A Jacko, François Sainfort, Melissa A Geller
A randomized controlled trial was conducted of a web-based intervention to improve advanced care planning in women with ovarian cancer. A secondary analysis of 35 randomized women focused on changes in distress and knowledge about ovarian cancer through distress monitoring and information tailored to patients' cognitive coping style (monitoring, blunting). Pre-/postresults indicated the Intervention group demonstrated lower distress (p = 0.06); blunting was associated with lower depression (p = 0.04); knowledge in both groups was unchanged...
May 23, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29791273/survivorship-care-needs-among-lgbt-cancer-survivors
#14
Julia Seay, Darryl Mitteldorf, Alena Yankie, William F Pirl, Erin Kobetz, Matthew Schlumbrecht
OBJECTIVE: To better understand survivorship care needs among LGBT cancer survivors. DESIGN: We administered an anonymous online survey. SAMPLE: LGBT cancer survivors living in the United States. METHODS: Participants were recruited via the National LGBT Cancer Project. The survey measured sociodemographic characteristics, social support, posttraumatic stress, and survivorship care needs. RESULTS: Approximately 72% of our 114 participants were cisgender male and 87% were white...
May 23, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29791230/assessing-anxiety-and-depression-in-cancer-patients
#15
Fiona Milligan, Fe Martinez, SohSoha Hassan Mohd Abdel Aal, Samah Abdelrehim Ahmed, Beverly Joby, Jean Sultan Matalam, Sujala Sukumaran Nair, Anthony De Leon Maxion, Safia Sayed, Soji Samson Melepeedikayil
BACKGROUND: empirical evidence suggests that anxiety and depression in cancer patients is underdiagnosed and subsequently this patient population receives little or no support or intervention to address their psychosocial needs. It is often difficult to distinguish between normal emotional distress experienced following a cancer diagnosis and anxiety and depression, which can have a significant impact on coping mechanisms and subsequent outcomes. AIM: a qualitative study using the Hospital Anxiety and Depression Scale (HADS) was undertaken in the National Centre for Cancer Care and Research in Qatar...
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29790951/internet-use-and-preventive-health-behaviors-among-couples-in-later-life-evidence-from-the-health-and-retirement-study
#16
Sangbo Nam, Sae Hwang Han, Megan Gilligan
Background and Objectives: The aim of this study was to examine the link between internet use and preventive health behaviors. We focused on couples to examine whether there were cross-partner associations between internet use and preventive health behaviors. Research Design and Methods: The data for this study came from the 2010 and 2012 waves of the Health and Retirement Study and the sample consisted of 5,143 pairs of coupled-individuals. Preventive health behaviors included cancer screenings (mammogram and prostate tests), cholesterol tests, and flu shots...
May 22, 2018: Gerontologist
https://www.readbyqxmd.com/read/29790905/the-hard-road-to-patient-centered-care-3-or-6-months-of-adjuvant-chemotherapy-for-patients-with-stage-iii-colon-cancer
#17
P Trensz, L Calvel, J E Kurtz
No abstract text is available yet for this article.
May 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29790861/assessing-mr-linac-radiotherapy-robustness-for-anatomical-changes-in-head-and-neck-cancer
#18
Robert W Chuter, Andrew Pollitt, Philip Whitehurst, Ranald I Mackay, Marcel van Herk, Alan McWilliam
The MR-Linac will provide excellent soft tissue contrast for on-treatment imaging. It is well known that the electron return effect (ERE) results in areas of increased and decreased dose at air/tissue boundaries, which can be compensated for in plan optimisation. However, anatomical changes may affect the quality of this compensation. In this paper we aim to quantify the interaction of anatomical changes with ERE in head and neck (H&N) cancer patients.
 
 Twenty patients treated with either 66 Gy or 60 Gy in 30 fractions were selected...
May 23, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29790787/colorectal-liver-metastases-a-pathologist-s-guide-to-creating-an-informative-report-and-improving-patient-care
#19
Mariana Moreno Prats, Eizaburo Sasatomi, Heather L Stevenson
CONTEXT: - In this era of minimally invasive procedures for diagnosis, prognosis, and treatment, pathologists are at the forefront of analyzing specimens and are expected to make more specific diagnoses, providing additional information from the material they receive. OBJECTIVE: - To familiarize pathologists with the essential components of surgical pathology reports for colorectal liver metastases (CRLM) resections. DATA SOURCES: - Colorectal cancer is the third most common cancer in the world and the liver is the most frequent site of metastases...
May 23, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29790491/advancements-in-microfluidic-technologies-for-isolation-and-early-detection-of-circulating-cancer-related-biomarkers
#20
REVIEW
Ankit Rana, Yuqian Zhang, Leyla Esfandiari
Early stage detection of cancer is essential for the improved long-term survival of patients. Currently, costly, extensively complex and invasive procedures, such as surgical tissue biopsies, are used for cancer screening. Thus, over the past few decades, advancements in microfluidics and lab-on-a-chip approaches have been made to develop minimally invasive and miniaturized platforms to identify and segregate circulating cancer biomarkers such as exosomes, circulating tumor cells (CTCs) and cell-free DNA (cfDNA) from body fluids...
May 23, 2018: Analyst
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