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https://www.readbyqxmd.com/read/28544379/a-widened-substrate-selectivity-filter-of-eukaryotic-formate-nitrite-transporters-enables-high-level-lactate-conductance
#1
Marie Wiechert, Holger Erler, André Golldack, Eric Beitz
Bacterial formate-nitrite transporters (FNT) regulate the metabolic flow of small weak mono-acids derived from anaerobic mixed-acid fermentation, such as formate, and further transport nitrite, and hydrosulfide. The eukaryotic Plasmodium falciparum FNT is vital for the malaria parasite by its ability to release the larger l-lactate substrate as the metabolic end product of anaerobic glycolysis in symport with protons preventing cytosolic acidification. However, the molecular basis for substrate discrimination by FNTs has remained unclear...
May 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28538150/lanthanides-report-calcium-sensor-in-the-vestibule-of-ryanodine-receptor
#2
Sándor Sárközi, István Komáromi, István Jóna, János Almássy
Ca(2+) regulates ryanodine receptor's (RyR) activity through an activating and an inhibiting Ca(2+)-binding site located on the cytoplasmic side of the RyR channel. Their altered sensitivity plays an important role in the pathology of malignant hyperthermia and heart failure. We used lanthanide ions (Ln(3+)) as probes to investigate the Ca(2+) sensors of RyR, because they specifically bind to Ca(2+)-binding proteins and they are impermeable to the channel. Eu(3+)'s and Sm(3+)'s action was tested on single RyR1 channels reconstituted into planar lipid bilayers...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28523362/transoral-endoscopic-thyroidectomy-our-initial-experience-using-a-new-endoscopic-technique
#3
Jun-Ook Park, Dong-Il Sun
BACKGROUND: A transoral approach has been experimentally introduced to the field of thyroid surgery and several groups in Asia have recently used the technique to treat patients. We performed transoral endoscopic thyroidectomies on patients with thyroid cancer or a benign tumor. METHODS: We reviewed the medical records of patients who underwent transoral endoscopic thyroid surgery between July 2016 and January 2017. A midline incision was made in the vestibule, and a 10 mm cannula was placed; then, the working space was widened by insufflating CO2 at a pressure of 5-6 mmHg...
May 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28511610/women-without-vulvodynia-can-have-a-positive-q-tip-test-a-cross-sectional-study
#4
Pedro Vieira-Baptista, Joana Lima-Silva, Jorge Beires, Gilbert Donders
BACKGROUND: Vulvodynia is a frequently missed pathology, often confused with vaginismus. The Q-tip test (QTT) is fundamental for the diagnosis; however, there is lack of data about its performance in asymptomatic women. OBJECTIVE: This study intended to evaluate the QTT for painful vestibular spots in asymptomatic women. METHODS: Q-tips were gently pressed at different areas of the vulvar vestibule to obtain a 0-10 score representing the pain felt...
May 17, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28499215/numerical-study-on-the-air-conditioning-characteristics-of-the-human-nasal-cavity
#5
Da-Woon Kim, Seung-Kyu Chung, Yang Na
The air-conditioning characteristics of the human nasal cavity were investigated using computational fluid dynamics. The wall layer was modeled as a heat conducting layer consisting of water with constant thickness placed on top of epithelial cells. By assuming constant tissue temperature, prescribed to be 36 (°)C, which is close to the alveolar condition, the proposed wall model yielded a spatially varying surface temperature distribution that is in reasonable agreement with the measurement studies in the literature...
April 30, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28470030/a-new-modified-pudendal-thigh-flap-of-vaginoplasty-including-reconstruction-of-vaginal-vestibule
#6
Youkou Ohmaru, Kensuke Sakata, Shin-Ichiro Hashiguchi, Hiroaki Tanaka, Hideaki Rikimaru, Kensuke Kiyokawa
We modified the conventional Pudendal Thigh Flap (PTF) on the vaginoplasty including reconstruction of vaginal vestibule. After the operation, no stenosis of the vaginal vestibule and opening of the vagina was observed. It is believed that our technique is cosmetically and functionally possible and a useful method.
2017: Case Reports in Plastic Surgery & Hand Surgery
https://www.readbyqxmd.com/read/28453271/an-efficient-metadynamics-based-protocol-to-model-the-binding-affinity-and-the-transition-state-ensemble-of-g-protein-coupled-receptor-ligands
#7
Noureldin Saleh, Passainte Ibrahim, Giorgio Saladino, Francesco Luigi Gervasio, Timothy Clark
A generally applicable metadynamics scheme for predicting the free energy profile of ligand binding to G-protein-coupled receptors (GPCRs) is described. A common and effective collective variable (CV) has been defined using the ideally placed and highly conserved Trp6.48 as a reference point for ligand-GPCR distance measurement and the common orientation of GPCRs in the cell membrane. Using this single CV together with well-tempered multiple-walker metadynamics with a funnel-like boundary allows an efficient exploration of the entire ligand binding path from the extracellular medium to the orthosteric binding site, including vestibule and intermediate sites...
May 8, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28443290/comparison-of-a-supraglottic-airway-device-v-gel-%C3%A2-with-blind-orotracheal-intubation-in-rabbits
#8
Sarah Engbers, Amy Larkin, Nicolas Rousset, Melanie Prebble, Mahesh Jonnalagadda, Cameron G Knight, Daniel S J Pang
INTRODUCTION: Achieving a secure airway in rabbits is generally considered more difficult than in cats or dogs. Their relatively large tongue, small oropharyngeal cavity and glottis limit direct visualization. A rabbit-specific supraglottic airway device (SGAD) may offer benefits over blind orotracheal intubation. ANIMALS AND METHODS: Fifteen adult New Zealand white rabbits were randomized to SGAD or orotracheal intubation (ETT). All animals were sedated with dexmedetomidine (0...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28432675/transoral-thyroidectomy-advantages-and-limitations
#9
G Dionigi, R P Tufano, J Russell, H Y Kim, E Piantanida, A Anuwong
In this opinion paper of the Journal of Endocrinological Investigation, leading experts in the field report on their current clinical experience with a novel approach for thyroid gland surgery, namely, "transoral thyroidectomy" (TOT). This feasible and novel surgical procedure does not require visible incisions and is, therefore, a truly scarless surgery. Patients meeting the following criteria can be considered as candidates for TOT: (a) an ultrasonographically (US) estimated thyroid diameter ≤10 cm; (b) US-estimated gland volume ≤45 mL; (c) nodule size ≤50 mm; (d) presence of a benign tumor such as a thyroid cyst or a single- or multi-nodular goiter; (e) Bethesda 3 and/or 4 category and (f) papillary microcarcinoma without the evidence of metastasis...
April 21, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28431535/ion-and-water-binding-sites-inside-an-occluded-hourglass-pore-of-a-trimeric-intracellular-cation-tric-channel
#10
Xiaomin Ou, Jianli Guo, Longfei Wang, Hanting Yang, Xiuying Liu, Jianyuan Sun, Zhenfeng Liu
BACKGROUND: Trimeric intracellular cation (TRIC) channels are crucial for Ca(2+) handling in eukaryotes and are involved in K(+) uptake in prokaryotes. Recent studies on the representative members of eukaryotic and prokaryotic TRIC channels demonstrated that they form homotrimeric units with the ion-conducting pores contained within each individual monomer. RESULTS: Here we report detailed insights into the ion- and water-binding sites inside the pore of a TRIC channel from Sulfolobus solfataricus (SsTRIC)...
April 22, 2017: BMC Biology
https://www.readbyqxmd.com/read/28413299/congenital-pouch-colon
#11
REVIEW
Rajiv Chadha, Niyaz Ahmed Khan
Congenital pouch colon (CPC) is an unusual abnormality in which a pouch-like dilatation of a shortened colon is associated with an anorectal malformation. It is categorized into four subtypes (Types I-IV) based on the length of normal colon proximal to the colonic pouch. In males, the pouch usually terminates in a colovesical fistula just proximal to the bladder neck. In girls, the terminal fistula opens either into the urethra or in the vestibule, close to the urethral opening. Girls usually have a double vagina with a wide inter-vaginal bridge, a monocornuate uterus on each side, and urinary incontinence due to a widely open bladder neck...
April 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28413076/detection-of-endolymphatic-hydrops-using-traditional-mr-imaging-sequences
#12
John H Keller, Barry E Hirsch, Ryan S Marovich, Barton F Branstetter
PURPOSE: The purpose of this study was to determine whether Meniere's disease (MD) produces endolymphatic cavity size changes that are detectable using unenhanced high-resolution T2-weighted MRI. MATERIALS & METHODS: This retrospective case-control study included patients with documented MD who had a high-resolution T2-weighted or steady-state free procession MRI of the temporal bones within one month of diagnosis, between 2002 and 2015. Patients were compared to age- and sex- matched controls...
April 6, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28412597/peptide-blockers-of-kv1-3-channels-in-t-cells-as-therapeutics-for-autoimmune-disease
#13
REVIEW
K George Chandy, Raymond S Norton
The voltage-gated Kv1.3 channel in T lymphocytes is a validated therapeutic target for diverse autoimmune diseases. Here we review the discovery of Kv1.3, its physiological role in T cells, and why it is an attractive target for modulating autoimmune responses. We focus on peptide inhibitors because the first Kv1.3-selective inhibitor in human trials is a peptide derived from a marine organism. Two broad classes of peptides block Kv1.3, the first from scorpions and the second from sea anemones. We describe their structures, their binding site in the external vestibule of Kv1...
April 13, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28412164/diagnosis-and-management-of-oropharyngeal-dysphagia-among-older-persons-state-of-the-art
#14
REVIEW
Omar Ortega, Alberto Martín, Pere Clavé
Oropharyngeal dysphagia (OD) is a condition recognized by the World Health Organization and defined as the difficulty or inability to move a bolus safely and effectively from the oral cavity to the esophagus, and can include aspirations, choking, and residue. OD is pandemic among different phenotypes of older people, affecting between 27% and 91% of the population 70 years or older. Although OD can be diagnosed by well-defined clinical methods and complementary explorations, in the clinical setting OD is seldom systematically screened and treated, and awareness among the medical/geriatric community is scarce...
April 12, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28409372/primary-hyperparathyroidism-treated-by-transoral-endoscopic-parathyroidectomy-vestibular-approach-toepva
#15
Thanyawat Sasanakietkul, Tobias Carling
BACKGROUND: Bilateral open cervical exploration with identifying all parathyroid glands and removing one or more enlarged parathyroid tumor(s) was the standard of care in primary hyperparathyroidism (pHPT). With the introduction of preoperative imaging and intraoperative parathyroid hormone (IOPTH) measurements [1, 2], various minimally invasive parathyroidectomy approaches have been developed, both open and endoscopic [3-8]. The most commonly used approach currently in the USA is the minimally invasive open parathyroidectomy (MIP), which can be performed in the ambulatory setting with excellent cure and minimal complication rates [9-12]...
April 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28405949/transoral-endoscopic-thyroidectomy-preliminary-experience-in-italy
#16
Gianlorenzo Dionigi, Alessandro Bacuzzi, Matteo Lavazza, Davide Inversini, Luigi Boni, Stefano Rausei, Hoon Yub Kim, Angkoon Anuwong
Transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a feasible novel surgical procedure that does not need visible incisions. We describe our initial experience with TOETVA. We recruited 15 patients who were willing to undergo TOETVA. Inclusion criteria were (a) patients who had a neck ultrasound (US) with a estimated thyroid diameter not larger than 10 cm; (b) US estimated gland volume ≤45 mL; (c) nodule size ≤50 mm; (d) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (e) follicular neoplasm; (f) papillary microcarcinoma without evidence of metastasis...
April 12, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28401629/a-1-470%C3%A2-nm-diode-laser-in-stapedotomy-mechanical-thermal-and-acoustic-effects
#17
Simone P C Koenraads, Tjeerd de Boorder, Wilko Grolman, Digna M A Kamalski
BACKGROUND AND OBJECTIVES: Multiple laser systems have been investigated for their use in stapes surgery in patients with otosclerosis. The diode 1,470 nm laser used in this study is an attractive laser system because it is easily transported and relatively inexpensive in use. This wavelength has relative high absorption in water. This study aimed to investigate the mechanical, thermal, and acoustic effects of the diode 1,470 nm laser on a stapes in an inner ear model. MATERIALS AND METHODS: Experiments were performed in an inner ear model including fresh frozen human stapes...
April 11, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28390650/garlic-burn-of-the-oral-mucosa-a-case-report-and-review-of-self-treatment-chemical-burns
#18
Richard J Vargo, Blake M Warner, Anitha Potluri, Joanne L Prasad
BACKGROUND AND OVERVIEW: Inappropriate self-treatment with topically applied therapeutic or nontherapeutic agents frequently results in mucosal burns. Although such chemical burns typically are associated with misuse of analgesics, investigators also have reported them in conjunction with topical application of a variety of other agents. CASE DESCRIPTION: The authors report an unusual case of a 49-year-old man seeking care for maxillary tooth pain who had an oral mucosal burn of the maxillary vestibule caused by topical application of crushed raw garlic...
April 5, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28390130/oral-diseases-a-14-year-experience-of-a-chilean-institution-with-a-systematic-review-from-eight-countries
#19
C Rivera, C Jones-Herrera, P Vargas, B Venegas, D Droguett
BACKGROUND: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce. MATERIAL AND METHODS: This study investigated the frequency of OD in a Chilean population. For this, we included all patients treated at the University of Talca (UTALCA, Chile) between 2001 and 2014...
May 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28390126/oral-thrombus-report-of-122-cases-with-clinically-descriptive-data
#20
P-L Tobouti, F-M Pigatti, M-C Martins-Mussi, S-C-O Machado de Sousa
BACKGROUND: The aim of the present study was to assess the frequency and characterize clinic-pathologic aspects of thrombus occurring as a single lesion or in association with other oral pathologies. MATERIAL AND METHODS: 122 cases of thrombus from the oral cavity were retrieved. Information regarding site of the lesion, age, sex and clinical diagnosis or hypothesis and associated lesions were collected from the patients' records. RESULTS: The lesions occurred in a wide age range but the 5th decade was the most prevalent and female patients were more affected...
May 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
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