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Vestibulitis

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https://www.readbyqxmd.com/read/28068300/early-postoperative-imaging-of-the-labyrinth-by-cone-beam-ct-after-stapes-surgery-for-otosclerosis-with-correlation-to-audiovestibular-outcome
#1
Aurélie Vandevoorde, Marc T Williams, Elsa Ukkola-Pons, Mary Daval, Denis Ayache
BACKGROUND: Sensorineural complications of stapes surgery are rare but potentially serious. Imaging is usually performed to identify an underlying cause, such as excessive intravestibular penetration of the prosthesis or pneumolabyrinth suggesting perilymphatic fistula. Unfortunately, there is very little data in an unselected series of uneventful patients.The aim of this study was to analyze the depth of prosthesis penetration within the vestibule and the rate of pneumolabyrinth the day or the day after the procedure by performing a cone beam computed tomography of the temporal bone in a cohort of unselected patients, and to correlate imaging findings to clinical outcome...
February 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28062309/a-local-inflammatory-renin-angiotensin-system-drives-sensory-axon-sprouting-in-provoked-vestibulodynia
#2
Zhaohui Liao, Anuradha Chakrabarty, Ying Mu, Aritra Bhattacherjee, Martha Goestch, Catherine M Leclair, Peter G Smith
: Vestibulodynia is a form of provoked vulvodynia characterized by profound tenderness, hyperinnervation, and frequently inflammation within well-defined areas of the human vestibule. Prior experiments in animal models show that inflammatory hypersensitivity and hyperinnervation occur in concert with establishment of a local renin-angiotensin system (RAS). Moreover, mechanical hypersensitivity and sensory axon sprouting are prevented by blocking effects of angiotensin II on AT2 receptors...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28050646/gentamicin-applied-to-the-oval-window-suppresses-vestibular-function-in-guinea-pigs
#3
E B King, R K Shepherd, D J Brown, J B Fallon
Intratympanic gentamicin therapy is widely used clinically to treat the debilitating symptoms of Ménière's disease. Cochleotoxicity is an undesirable potential side effect of the treatment and the risk of hearing loss increases proportionately with gentamicin concentration in the cochlea. It has recently been shown that gentamicin is readily absorbed through the oval window in guinea pigs. The present study uses quantitative functional measures of vestibular and cochlea function to investigate the efficacy of treating the vestibule by applying a small volume of gentamicin onto the stapes footplate in guinea pigs...
January 3, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28032220/transoral-endoscopic-parathyroidectomy-vestibular-approach-a-novel-scarless-parathyroid-surgery
#4
Thanyawat Sasanakietkul, Pornpeera Jitpratoom, Angkoon Anuwong
BACKGROUND: Natural orifice transluminal endoscopic surgery developed for neck surgery become increasing popular. Herein, an innovative transoral endoscopic parathyroidectomy vestibular approach (TOEPVA) was developed for primary hyperparathyroidism (PHPT) and renal hyperparathyroidism (rHPT). METHODS: Incisions were made at the oral vestibule under the inferior lip. A 10-mm trocar was inserted through the center of the oral vestibule with two 5-mm trocars laterally...
December 28, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28027715/enlarged-vestibular-aqueducts-and-other-inner-ear-abnormalities-in-patients-with-down-syndrome
#5
C M Clark, H H Patel, S G Kanekar, H Isildak
BACKGROUND: Histopathological anomalies of inner-ear structures in individuals with Down syndrome have been well documented; however, few studies have examined the radiological features. METHODS: A retrospective study was conducted of temporal bone computed tomography images in 38 individuals (75 ears) with Down syndrome to evaluate the prevalence of inner-ear abnormalities and assess vestibular aqueduct widths. RESULTS: Inner-ear anomalies were identified in 20 of the 38 individuals (52...
December 28, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28024377/kinetics-of-t3-dna-ligase-catalyzed-phosphodiester-bond-formation-measured-using-the-%C3%AE-hemolysin-nanopore
#6
Cherie S Tan, Jan Riedl, Aaron M Fleming, Cynthia J Burrows, Henry S White
The latch region of the wild-type α-hemolysin (α-HL) protein channel can be used to distinguish single base modifications in double-stranded DNA (dsDNA) via ion channel measurements upon electrophoretic capture of dsDNA in the vestibule of α-HL. Herein, we investigated the use of the latch region to detect a nick in the phosphodiester DNA backbone. The presence of a nick in the phosphodiester backbone of one strand of the duplex results in a significant increase in both the blockade current and noise level relative to the intact duplex...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28017460/vocal-tract-adjustments-of-dysphonic-and-non-dysphonic-women-pre-and-post-flexible-resonance-tube-in-water-exercise-a-quantitative-mri-study
#7
Rosiane Yamasaki, Emi Z Murano, Eloisa Gebrim, Adriana Hachiya, Arlindo Montagnoli, Mara Behlau, Domingos Tsuji
OBJECTIVE: To compare vocal tract (VT) adjustments of dysphonic and non-dysphonic women before and after flexible resonance tube in water exercise (FRTWE) at rest and during phonation using magnetic resonance imaging. STUDY DESIGN: Prospective study. METHODS: Twenty women, aged 20-40 years, 10 dysphonic with vocal nodules (VNG) and 10 controls (CG), underwent four sets of sagittal VT MRI: two pre-FRTWE, at rest and during phonation, and two post-FRTWE, during phonation and at rest...
December 22, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27999985/mri-of-endolymphatic-hydrops-in-patients-with-meniere-s-disease-a-case-controlled-study-with-a-simplified-classification-based-on-saccular-morphology
#8
Arnaud Attyé, Michael Eliezer, Naïla Boudiaf, Irène Tropres, David Chechin, Sébastien Schmerber, Georges Dumas, Alexandre Krainik
OBJECTIVES: Endolymphatic hydrops (EH) can be studied in patients by MRI. With the semi-quantitative grading system, previous imaging studies showed discrepancies in the occurrence and grading of EH in patients with Meniere's disease (MD). Here, we compared the inversion of the saccule to utricle area ratio (SURI) with the semi-quantitative method of grading conventionally used to diagnose MD. METHODS: Imaging was carried out on a 3-T MRI scanner. We performed 3D-FLAIR sequences 4 h after a single intravenous dose of contrast agent...
December 20, 2016: European Radiology
https://www.readbyqxmd.com/read/27991905/structure-of-the-polycystic-kidney-disease-trp-channel-polycystin-2-pc2
#9
Mariana Grieben, Ashley C W Pike, Chitra A Shintre, Elisa Venturi, Sam El-Ajouz, Annamaria Tessitore, Leela Shrestha, Shubhashish Mukhopadhyay, Pravin Mahajan, Rod Chalk, Nicola A Burgess-Brown, Rebecca Sitsapesan, Juha T Huiskonen, Elisabeth P Carpenter
Mutations in either polycystin-1 (PC1 or PKD1) or polycystin-2 (PC2, PKD2 or TRPP1) cause autosomal-dominant polycystic kidney disease (ADPKD) through unknown mechanisms. Here we present the structure of human PC2 in a closed conformation, solved by electron cryomicroscopy at 4.2-Å resolution. The structure reveals a novel polycystin-specific 'tetragonal opening for polycystins' (TOP) domain tightly bound to the top of a classic transient receptor potential (TRP) channel structure. The TOP domain is formed from two extensions to the voltage-sensor-like domain (VSLD); it covers the channel's endoplasmic reticulum lumen or extracellular surface and encloses an upper vestibule, above the pore filter, without blocking the ion-conduction pathway...
December 19, 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27981794/reproductive-tract-histology-in-south-american-fur-seal-pups-arctophoca-australis
#10
Helena Katz, Olle Johansson
In the present study, a detailed histological description of the female reproductive tract of South American fur seal (Arctophoca australis) pups has been conducted. The uterine tube was covered by cuboidal to columnar epithelium; nerve fibers were present in the mesosalpinx and beneath the muscular layer. The uterus was bipartitus; the endometrial surface of the horns was lined by a simple cuboidal or columnar epithelium with deep tubular glands; caudally ("the transition area"), the epithelium changed to pseudostratified columnar, few tubular glands were present and the myometrium increased in width...
December 16, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27977828/modified-lip-repositioning-with-esthetic-crown-lengthening-a-combined-approach-to-treating-excessive-gingival-display
#11
Isis M Sánchez, Sadja Gaud-Quintana, Jacob K Stern
Lip repositioning surgery to address excessive gingival display induced by different etiologies has received major attention recently. Several techniques and variations have been reported, including myotomy or repositioning of the levator labii superioris muscle, Le Fort impaction, maxillary gingivectomies, botulinum toxin injections, and lip stabilization. This study reports a case of excessive gingival display treated by a modified combined approach. A 25-year-old woman with a 4- to 8-mm gingival display when smiling caused by a combination of short clinical crowns induced by an altered passive eruption and hypermobility of the upper lip underwent a staged esthetic crown-lengthening procedure followed by a modified lip repositioning technique...
January 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27966884/ligand-binding-in-the-extracellular-vestibule-of-the-neurotransmitter-transporter-homologue-leut
#12
Julie Grouleff, Heidi Koldsø, Yinglong Miao, Birgit Schiøtt
The human monoamine transporters (MATs) facilitate the reuptake of monoamine neurotransmitters from the synaptic cleft. MATs are linked to a number of neurological diseases and are the targets of both therapeutic and illicit drugs. Until recently, no high-resolution structures of the human MATs existed, and therefore, studies of this transporter family have relied on investigations of the homologues bacterial transporters such as the leucine transporter LeuT, which has been crystallized in several conformational states...
December 14, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27965122/assembling-a-functional-clitoris-and-vulva-from-a-pseudo-penis-a-surgical-technique-for-an-adult-woman-with-congenital-adrenal-hyperplasia
#13
Wiebren A A Tjalma
BACKGROUND: Congenital adrenal hyperplasia (CAH) is associated with a genital deformation that may cause a negative body image. The genital ambiguity is generally "corrected" surgically during early infancy. The advantage is a psychological benefit. The disadvantages are multiple surgical procedures and the loss of orgasm. CASE: A 22-year-old woman with CAH consulted for genital reconstructive surgery. She had a pseudo-penis of 4 cm and could achieve an orgasm by masturbating...
December 10, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27965007/effects-of-chin-down-maneuver-on-the-parameters-of-swallowing-function-following-esophagectomy-with-three-field-lymphadenectomy-examined-by-videofluoroscopy
#14
Yoshihiko Kumai, Naoya Yoshida, Yuta Kamenosono, Keigo Matsubara, Yasuhiro Samejima, Hideo Baba, Eiji Yumoto
OBJECTIVES: This study quantitatively determined the effect of the chin-down maneuver following esophagectomy with three-field lymphadenectomy (3FL) on pharyngeal residue, upper esophageal sphincter (UES) opening, and laryngeal closure. DESIGN: Prospective data were collected from a pharyngeal videofluoroscopic swallowing study. SETTING: Dysphagia clinics at the ENT Department of Kumamoto University Hospital. PARTICIPANTS: A total 14 patients (mean age, 65...
December 10, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27958207/cataract-surgery-in-mobile-eye-surgical-unit-safe-and-viable-alternative
#15
Rajesh Pioneer Sangameswaran, Gajendra Kumar Verma, Narayanan Raghavan, Jayaraj Joseph, Mohanasankar Sivaprakasam
AIM: The aim of this study was to evaluate the utility and safety of a mobile eye surgical unit (MESU) in providing quality cataract surgery for the indigent rural population with poor access to quality eye care. MATERIALS AND METHODS: Two buses connected by a vestibule were built to meet the requirements for a self-sufficient operation theater (OT). In every camp, safe transportation of units, good alignment of buses, safe water, and maintenance of sterile environment were achieved with optimal utilization of OT...
November 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27956722/effect-of-goggle-slippage-on-the-video-head-impulse-test-outcome-and-its-mechanisms
#16
Myung-Whan Suh, Jae Hong Park, Seong Il Kang, Jae Hyun Lim, Moo Kyun Park, Seong Keun Kwon
OBJECTIVES: The aim of this study was to quantitatively measure the tightness of the goggle strap during the video head impulse test (vHIT) and to identify slippage-induced artifacts according to tightness. We aimed to elucidate the mechanism of faulty gain caused by goggle slippage and explain the typical artifacts associated with it. SUBJECTS AND METHODS: An endotracheal tube cuff manometer was coupled to the EyeSeeCam vHIT system (Interacoustics, Assens, Denmark) to monitor strap tightness...
January 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/27942898/assessment-of-endolymphatic-hydrops-and-otolith-function-in-patients-with-m%C3%A3-ni%C3%A3-re-s-disease
#17
Tomoko Okumura, Takao Imai, Yasumitsu Takimoto, Noriaki Takeda, Tadashi Kitahara, Atsuhiko Uno, Takefumi Kamakura, Yasuhiro Osaki, Yoshiyuki Watanabe, Hidenori Inohara
Ménière's disease is associated with hydrops of the inner ear endolymphatic space, and histopathologically, the cochlea and vestibule are usually involved. We used gadolinium-enhanced magnetic resonance imaging and measured cervical and ocular vestibular evoked myogenic potentials and the gain in the utricular induced linear vestibulo-ocular reflex to test the hypothesis that vestibular hydrops in Ménière's disease patients is associated with otolith organ dysfunction. We evaluated 21 patients diagnosed with unilateral definitive Ménière's disease using gadolinium magnetic resonance imaging to detect endolymphatic hydrops in the cochlea and vestibule...
December 10, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27941975/novel-and-de-novo-mutations-extend-association-of-pou3f4-with-distinct-clinical-and-radiological-phenotype-of-hearing-loss
#18
Agnieszka Pollak, Urszula Lechowicz, Anna Kędra, Piotr Stawiński, Małgorzata Rydzanicz, Mariusz Furmanek, Małgorzata Brzozowska, Maciej Mrówka, Henryk Skarżyński, Piotr H Skarżyński, Monika Ołdak, Rafał Płoski
POU3F4 mutations (DFNX2) are the most prevalent among non-syndromic X-linked hearing loss (HL) identified to date. Clinical manifestations of DFNX2 usually comprise congenital HL either sensorineural or mixed, a tendency towards perilymphatic gusher during otologic surgery and temporal bone malformations. The aim of the present study was to screen for POU3F4 mutations in a group of 30 subjects with a suggestive clinical phenotype as well as a group (N = 1671-2018) of unselected hearing loss patients. We also planned to analyze audiological and radiological features in patients with HL caused by POU3F4 defects...
2016: PloS One
https://www.readbyqxmd.com/read/27938609/-sox10-mutation-is-relevant-to-inner-ear-malformation-in-patients-with-waardenburg-syndrome
#19
G Y Xu, Q Q Hao, L L Zhong, W Ren, Y Yan, R Y Liu, J N Li, W W Guo, H Zhao, S M Yang
Objective: To determine the relevance between the SOX10 mutation and Waardenburg syndrome (WS) accompanied with inner ear abnormality by analyzing the inner ear imaging results and molecular and genetic results of the WS patients with the SOX10 mutation. Methods: This study included 36 WS in patients during 2001 and 2015 in the department of otorhinolaryngology head and neck surgery, Chinese Peoples's Liberation Army General Hospital. The condition of the inner ear of each patient was assessed by analyzing HRCT scans of the temporal bone and MRI scans of the brain and internal auditory canal...
November 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27931081/presence-and-distribution-of-yeasts-in-the-reproductive-tract-of-healthy-female-horses
#20
A Azarvandi, A R Khosravi, H Shokri, M Talebkhan Garoussi, F Gharahgouzlou, G Vahedi, A Sharifzadeh
BACKGROUND: Yeasts are commensal organisms found in the reproductive and gastrointestinal tracts, and on the skin and other mucosa in mammals. OBJECTIVES: The purpose of this study was to isolate and identify the yeast flora in the caudal reproductive tract of healthy female horses. STUDY DESIGN: Longitudinal study. METHODS: A total of 453 samples were collected using double guarded swabs from the vestibule, clitoral fossa and vagina of 151 horses...
December 8, 2016: Equine Veterinary Journal
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