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https://www.readbyqxmd.com/read/29771836/palatal-wiring-renewing-an-old-technique-circumpalatal-wiring
#1
Amin Rahpeyma, Saeedeh Khajehahmadi
Circumpalatal wiring has 2 negative points. The first is premature loosening of the wire and the second is tongue irritation caused by exposed wire in roof of the mouth. In this article, a modified technique (palatal wiring) is introduced in which these 2 problems are targeted. In this technique, a small bur hole is created into the hard palate, without the need for flap reflection and wire is passed through it, grasps in the nose, and returns to the oral cavity via sublabial puncture point then 2 ends are twisted in labial vestibule...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771078/-analysis-of-the-difference-between-the-results-of-caloric-tests-and-video-head-pulse-tests-in-patients-with-vestibular-migraine-and-vestibular-neuritis
#2
W Wang, Y C Yang, J H Zhuang, F Li, B Gao
Objective: To compare the results of caloric tests and video head impulse tests (VHIT) in patients with vestibular migraine (VM) and vestibular neuritis (VN), so as to provide help for the differential diagnosis of the two patients. Method: Retrospectively analyze VM and VN patients within 2 weeks of onset from August 1, 2016 to December 31, 2017 in neurology clinic of the Changzheng Hospital of Second Military Medical University, all patients were examined by caloric tests and VHIT, and the results of the two groups were compared and analyzed...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771050/-fibrous-hemangioma-of-esophagus-portal-a-case-report
#3
Y P Wang, L X Li
A 33 year old male patient has found in the oral cavity tumor with nausea and vomiting after 20 days ago. The patients feel pharyngeal foreign body sensation, occasional sense of suffocation, the oropharyngeal tumor disappeared and foreign body sensation disappeared after swallowing. The patients without angina, no hemoptysis, no hoarseness, no acid reflux symptoms and weight loss phenomenon. The gastroscope showed giant tumor, esophagus smooth surface, visible local gray blue blood vessels, from the entrance of esophagus has been extended to the esophagus from the upper incisors 25 cm...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29769265/reciprocal-negative-regulation-between-lmx1a-and-lmo4-is-required-for-inner-ear-formation
#4
Yanhan Huang, Jennifer Hill, Andrew Yatteau, Loksum Wong, Tao Jiang, Jelena Petrovic, Lin Gan, Lijin Dong, Doris K Wu
LIM-domain containing transcription factors (LIM-TFs) are conserved factors important for embryogenesis. The specificity of these factors in transcriptional regulation is conferred by the complexes they form with other proteins such as LIM-domain-binding (Ldb) proteins and LIM-domain only (LMO) proteins. Unlike LIM-TF, these proteins do not bind DNA directly. LMO are negative regulators of LIM-TF and they function by competing with LIM-TFs for binding to Ldbs. Although the LIM-TF Lmx1a is expressed in the developing mouse hindbrain, which provides many of the extrinsic signals for inner ear formation, conditional knockout embryos of both sexes show that the inner ear source of Lmx1a is the major contributor of ear patterning...
May 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29760579/the-effect-of-transcutaneous-neuromuscular-electrical-stimulation-on-laryngeal-vestibule-closure-timing-in-swallowing
#5
Christopher R Watts, Matthew J Dumican
Background: The purpose of this study was to investigate the effect of transcutaneous neuromuscular electrical stimulation (NMES) on the timing of laryngeal vestibule closure during the pharyngeal stage of swallowing in healthy adults. The theoretical framework proposed that NMES applied to these muscles would present a perturbation to laryngeal vestibular closure reaction time (the amount of time for the laryngeal vestibule to close once the swallowing reflex has been triggered) by providing an antagonistic force to the direction of vestibule closure...
2018: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/29750273/video-head-impulse-test-to-preoperatively-identify-the-nerve-of-origin-of-vestibular-schwannomas
#6
Felipe Constanzo, Patricia Sens, Bernardo Corrêa de Almeida Teixeira, Ricardo Ramina
BACKGROUND: Identification of the nerve of origin in vestibular schwannoma (VS) is an important prognostic factor for hearing preservation surgery. Thus far, vestibular functional tests and magnetic resonance imaging have not yielded reliable results to preoperatively evaluate this information. The development of the video head impulse test (vHIT) has allowed a precise evaluation of each semicircular canal, and its localizing value has been tested for some peripheral vestibular diseases, but not for VS...
May 10, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29745448/early-development-of-the-human-dentition-revisited
#7
REVIEW
Maria Hovorakova, Herve Lesot, Miroslav Peterka, Renata Peterkova
In this review, classical data on the early steps in human odontogenesis are summarized and updated with specific insights into the development of the upper and lower embryonic jaws to help in understanding some oral pathologies. The initial step of human odontogenesis is classically characterized by two parallel horseshoe-shaped epithelial laminae. These originate from the oral epithelium and an ingrowth into the jaw mesenchyme: the internal dental lamina gives rise to deciduous tooth primordia, while the external vestibular lamina represents the developmental base of the oral vestibule...
May 10, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29725764/a-preliminary-videofluoroscopic-investigation-of-swallowing-physiology-and-function-in-individuals-with-oculopharyngeal-muscular-dystrophy-opmd
#8
Ashley A Waito, Catriona M Steele, Melanie Peladeau-Pigeon, Angela Genge, Zohar Argov
Dysphagia is one of the primary symptoms experienced by individuals with Oculopharyngeal Muscular Dystrophy (OPMD). However, we lack understanding of the discrete changes in swallowing physiology that are seen in OPMD, and the resulting relationship to impairments of swallowing safety and efficiency. This study sought to describe the pathophysiology of dysphagia in a small sample of patients with OPMD using a videofluoroscopy examination (VFSS) involving 3 × 5 mL boluses of thin liquid barium (22% w/v)...
May 3, 2018: Dysphagia
https://www.readbyqxmd.com/read/29706484/air-conditioning-analysis-among-human-nasal-passages-with-anterior-anatomical-variations
#9
Jiawei Ma, Jingliang Dong, Yidan Shang, Kiao Inthavong, Jiyuan Tu, Dennis O Frank-Ito
A major functional role of the nasal cavity is air conditioning of the inspired environmental air to near alveolar conditions. It is well known that the anatomical disparities among nasal passages can change airflow patterns to a great extent. However, its effect on nasal air conditioning performance remains largely unexplored. This research investigated the nasal air conditioning performance among nasal models with distinct vestibule phenotypes, including subjects with and without vestibule notches. For the mass transfer, we used a two-film theory model to determine the species transport...
April 27, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29693258/microvascular-anatomy-of-the-brain-of-the-adult-pipid-frog-xenopus-laevis-daudin-a-scanning-electron-microscopic-study-of-vascular-corrosion-casts
#10
Alois Lametschwandtner, Bernd Minnich
To demonstrate the 3D microvascular anatomy of the brain of the model organism Xenopus laevis Daudin scanning electron microscopy of vascular corrosion casts was correlated with light microscopy of stained 7 µm thick serial tissues sections. Results showed that supplying arteries descended from the leptomeningeal surface without remarkable branchings straight to the subventricular zone where they branched and capillarized. Capillaries showed few H- and/or Y-shaped anastomoses during their centrifugal course toward the leptomeningeal surface where they drained into cerebral venules and veins...
April 25, 2018: Journal of Morphology
https://www.readbyqxmd.com/read/29680680/pneumolabyrinth-intracochlear-and-vestibular-fluid-loss-after-cochlear-implantation
#11
Hideaki Moteki, Yasunari Fujinaga, Tetsuya Goto, Shin-Ichi Usami
The present case was a 38-year-old male who presented with progressive hearing loss, resulting in profound bilateral hearing loss. He had a past history of childhood medulloblastoma, which was treated with posterior fossa craniotomy and radiotherapy. A ventriculoperitoneal (VP) shunt was put in place to manage the hydrocephalus. Cochlear implantation (CI) was carried out on his right ear by a standard procedure. At CI activation, the electric impedance of the electrode was very high, and computed tomography revealed that there was no area of liquid density, suggesting depletion of the perilymph in the cochlea and vestibule...
April 18, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29678557/improvements-to-the-vulva-vestibule-urethral-meatus-and-vagina-in-women-treated-with-ospemifene-for-moderate-to-severe-dyspareunia-a-prospective-vulvoscopic-pilot-study
#12
Sue W Goldstein, Ashley G Winter, Irwin Goldstein
INTRODUCTION: Ospemifene, an oral selective estrogen receptor modulator approved for the treatment of mild to moderate dyspareunia from menopause, has been shown to moderate sexual pain and vaginal epithelial cell characteristics. However, no prospective vulvoscopic studies have been performed. AIM: To examine, in menopausal women taking ospemifene 60 mg daily, changes to the vulva, vestibule, urethral meatus, and vaginal region over 20 weeks using vulvoscopy in a prospective open-label pilot study...
April 17, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29673107/could-adenosine-recognize-its-receptors-with-a-stoichiometry-other-than-1-1
#13
Giuseppe Deganutti, Veronica Salmaso, Stefano Moro
One of the most largely accepted concepts in the G protein-coupled receptors (GPCRs) field is that the ligand, either agonist or antagonist, recognizes its receptor with a stoichiometry of 1 : 1. Recent experimental evidence, reporting ternary complexes formed by GPCR:orthosteric: allosteric ligands, has complicated the ligand-receptor 1 : 1 binding scenario. Molecular modeling simulations have been used to retrieve insights on the whole ligand-receptor recognition process, beyond information on the final bound state provided by experimental techniques...
April 19, 2018: Molecular Informatics
https://www.readbyqxmd.com/read/29670280/mechanism-of-nmda-receptor-channel-block-by-mk-801-and-memantine
#14
Xianqiang Song, Morten Ø Jensen, Vishwanath Jogini, Richard A Stein, Chia-Hsueh Lee, Hassane S Mchaourab, David E Shaw, Eric Gouaux
The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 . Owing to the lack of high-resolution structural studies of the NMDA receptor, the mechanism by which ion-channel blockers occlude ion permeation is not well understood. Here we show that removal of the amino-terminal domains from the GluN1-GluN2B NMDA receptor yields a functional receptor and crystals with good diffraction properties, allowing us to map the binding site of the NMDA receptor blocker, MK-801...
April 18, 2018: Nature
https://www.readbyqxmd.com/read/29623936/cell-proliferation-during-hair-cell-regeneration-induced-by-math-1-in-vestibular-epithelia-in-vitro
#15
Yi-Bo Huang, Rui Ma, Juan-Mei Yang, Zhao Han, Ning Cong, Zhen Gao, Dongdong Ren, Jing Wang, Fang-Lu Chi
Hair cell regeneration is the fundamental method of correcting hearing loss and balance disorders caused by hair cell damage or loss. How to promote hair cell regeneration is a hot focus in current research. In mammals, cochlear hair cells cannot be regenerated and few vestibular hair cells can be renewed through spontaneous regeneration. However, Math1 gene transfer allows a few inner ear cells to be transformed into hair cells in vitro or in vivo. Hair cells can be renewed through two possible means in birds: supporting cell differentiation and transdifferentiation with or without cell division...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29621089/intense-instantaneous-and-shooting-pain-during-local-anesthesia-for-implant-surgery
#16
Antonio Scarano, Bruna Sinjari, Felice Lorusso, Carmen Mortellaro, Cristian D'Ovidio, Francesco Carinci
Administration of local anesthetics is daily routine for most dental practitioners. Normally, the effect is achieved, and no adverse effects are seen. In this article, the authors describe the complications of immediate, intense and shooting pain, numbness, and marked pallor of the cheek, which occurred during infiltration of a local anesthetic in buccal vestibule infiltration. The patients moved suddenly because of pain and marked pallor of the cheek near the root of the nose and lower eyelid pallor was observed...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29618887/comparison-of-ropivacaine-0-75-and-lignocaine-2-with-1-200-000-adrenaline-in-dental-extractions-single-blind-clinical-trial
#17
Vishal Bansal, Deval Kumar, Apoorva Mowar, Avi Bansal
Introduction: The aim of this study was to evaluate the efficacy, safety and clinical acceptability of the local anaesthetic agent ropivacaine 0.75 % in comparison with lignocaine 2 % with adrenaline 1:200,000 in minor oral surgical procedures. Methods: Forty-seven patients, who required bilateral extractions in a single arch, were included in this study. One hundred and sixty-six extractions were performed and all the patients were administered nerve blocks/infiltration...
June 2018: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29603475/transoral-endoscopic-thyroid-surgery-via-the-tri-vestibular-approach-with-a-hybrid-space-maintaining-method-a-preliminary-report
#18
Yong Wang, Ziyi Zhang, Qunzi Zhao, Qiuping Xie, Haichao Yan, Xing Yu, Cheng Xiang, Maolin Zhang, Ping Wang
BACKGROUND: Transoral endoscopic thyroid surgery has been introduced in a few institutions. The purpose of this study was to present an innovative hybrid space-maintaining method for the tri-vestibular approach. METHODS: Eighteen consecutive patients underwent transoral endoscopic thyroidectomy. Three incisions were made in the vestibule. The surgical space was maintained with CO2 insufflation along with a suspension device. Thyroidectomy and central neck dissection (CND) were performed safely and effectively...
March 30, 2018: Head & Neck
https://www.readbyqxmd.com/read/29589117/the-degenerin-region-of-the-human-bile-acid-sensitive-ion-channel-basic-is-involved-in-channel-inhibition-by-calcium-and-activation-by-bile-acids
#19
Alexandr V Ilyaskin, Sonja A Kirsch, Rainer A Böckmann, Heinrich Sticht, Christoph Korbmacher, Silke Haerteis, Alexei Diakov
The bile acid-sensitive ion channel (BASIC) is a member of the ENaC/degenerin family of ion channels. It is activated by bile acids and inhibited by extracellular Ca2+ . The aim of this study was to explore the molecular mechanisms mediating these effects. The modulation of BASIC function by extracellular Ca2+ and tauro-deoxycholic acid (t-DCA) was studied in Xenopus laevis oocytes heterologously expressing human BASIC using the two-electrode voltage-clamp and outside-out patch-clamp techniques. Substitution of aspartate D444 to alanine or cysteine in the degenerin region of BASIC, a region known to be critically involved in channel gating, resulted in a substantial reduction of BASIC Ca2+ sensitivity...
March 27, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29588525/succinate-acetate-permease-from-citrobacter-koseri-is-an-anion-channel-that-unidirectionally-translocates-acetate
#20
Biao Qiu, Bingqing Xia, Qingtong Zhou, Yan Lu, Miaomiao He, Kazuya Hasegawa, Zhiqiang Ma, Fengyu Zhang, Lichuan Gu, Qionglei Mao, Feng Wang, Suwen Zhao, Zhaobing Gao, Jun Liao
Acetate is an important metabolite in metabolism and cell signaling. Succinate-Acetate Permease (SatP) superfamily proteins are known to be responsible for acetate transport across membranes, but the nature of this transport remains unknown. Here, we show that the SatP homolog from Citrobacter koseri (SatP_Ck) is an anion channel that can unidirectionally translocate acetate at rates of the order of ~107  ions/s. Crystal structures of SatP_Ck in complex with multiple acetates at 1.8 Å reveal that the acetate pathway consists of four acetate-binding sites aligned in a single file that are interrupted by three hydrophobic constrictions...
March 27, 2018: Cell Research
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