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Vestibulitis

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https://www.readbyqxmd.com/read/28230212/establishment-of-planar-cell-polarity-is-coupled-to-regional-cell-cycle-exit-and-cell-differentiation-in-the-mouse-utricle
#1
Xiaoyu Yang, Xiaoqing Qian, Rui Ma, Xinwei Wang, Juanmei Yang, Wenwei Luo, Ping Chen, Fanglu Chi, Dongdong Ren
Sensory hair cells are coordinately oriented within each inner ear sensory organ to exhibit a particular form of planar cell polarity (PCP) necessary for mechanotransduction. However, the developmental events associated with establishing PCP in the vestibule are unclear, hindering data interpretation and employment of the vestibule for PCP studies. Herein, we investigated PCP of the mouse vestibular organs. We further characterised cell cycle exit, cell differentiation, and PCP establishment in the utricle...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220492/magnetic-resonance-imaging-of-intratympanic-gadolinium-helps-differentiate-vestibular-migraine-from-m%C3%A3-ni%C3%A3-re-disease
#2
Wenfang Sun, Ping Guo, Tongli Ren, Wuqing Wang
OBJECTIVES/HYPOTHESIS: To study the differential diagnosis of vestibular migraine (VM) and Ménière disease (MD) by using magnetic resonance imaging (MRI) of intratympanic gadolinium. STUDY DESIGN: Prospective cohort study. METHODS: Definite MD patients (n = 30) and definite or probable VM patients (n = 30) were included, and the two groups were age and sex matched. Three-dimensional real inversion recovery (3D-real-IR) MRI was performed 24 hours after bilateral intratympanic gadolinium to assess the presence and degree of endolymphatic hydrops (EH)...
February 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28194754/requirement-of-extracellular-ca-2-binding-to-specific-amino-acids-for-heat-evoked-activation-of-trpa1
#3
Erkin Kurganov, Shigeru Saito, Claire T Saito, Makoto Tominaga
Transient receptor potential ankyrin 1 (TRPA1) is a homotetrameric nonselective cation-permeable channel that has six transmembrane domains and cytoplasmic N- and C-termini. The N-terminus is characterized by an unusually large number of ankyrin repeats. Although the 3-dimensional structure of human TRPA1 has been determined, and TRPA1 channels from insects to birds are known to be activated by heat stimulus, the mechanism for temperature-dependent TRPA1 activation is unclear. We previously reported that extracellular Ca(2+) , but not intracellular Ca(2+) , plays an important role in heat-evoked TRPA1 activation in green anole lizards (gaTRPA1)...
February 14, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28183995/structure-of-a-eukaryotic-voltage-gated-sodium-channel-at-near-atomic-resolution
#4
Huaizong Shen, Qiang Zhou, Xiaojing Pan, Zhangqiang Li, Jianping Wu, Nieng Yan
Voltage-gated sodium (Nav) channels are responsible for the initiation and propagation of action potentials. They are associated with a variety of channelopathies and are targeted by multiple pharmaceutical drugs and natural toxins. Here, we report the cryo-EM structure of a putative Nav channel from American cockroach (designated NavPaS) at 3.8-Å resolution. The voltage sensing domains (VSDs) of the four repeats exhibit distinct conformations. The entrance to the asymmetric selectivity filter vestibule is guarded by heavily glycosylated and disulfide bond-stabilized extracellular loops...
February 9, 2017: Science
https://www.readbyqxmd.com/read/28182829/transoral-endoscopic-thyroidectomy-vestibular-approach-toetva-from-a-to-z
#5
Gianlorenzo Dionigi, Matteo Lavazza, Alessandro Bacuzzi, Davide Inversini, Vincenzo Pappalardo, Ralph P Tufano, Hoon Yub Kim, Angkoon Anuwong
We depict the transoral endoscopic thyroidectomy vestibular approach (TOETVA). Patient selection criteria are (1) ultrasonographically (US) estimated thyroid diameter no larger than 10cm, (2) US estimated gland volume ≥45mL, (3) nodule size ≥5mm, (4) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter, (5) follicular neoplasm, and (6) papillary microcarcinoma without evidence of metastasis. TOETVA is carried out through a three-port technique placed at the oral vestibule, one 10mm port for 30° endoscope and two additional 5mm ports for dissecting and coagulating instruments...
February 7, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28181331/effects-of-chin-up-posture-on-the-sequence-of-swallowing-events
#6
Irene Calvo, Kirstyn L Sunday, Phoebe Macrae, Ianessa A Humbert
BACKGROUND: Chin-up posture is frequently used to manage oral dysphagia after head and neck cancer. This prospective study investigates the effects of chin-ups on the sequence of pharyngeal swallowing events. METHODS: Twelve healthy young adults performed 45 consecutive swallows of 5 mL water across 3 phases on videofluoroscopy: 5 swallows in the neutral head position; 30 swallows during chin-up posture; and 10 swallows in the neutral head position. Swallowing kinematic and bolus flow measures for 9 swallowing events were recorded...
February 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28169906/the-possible-role-of-endoscopy-in-diagnosis-of-benign-tumors-of-the-nasal-cavity
#7
Hyun Jin Min, Seog-Kyun Mun, Sei Young Lee, Kyung Soo Kim
BACKGROUND: Benign tumors of the nasal cavity represent a large variety of different histopathological entities. Although advances in nasal endoscopy over the past couple of decades have made it possible to detect the vast majority of these lesions, accurate diagnosis and proper management can be delayed since they are misdiagnosed as inflammatory paranasal sinus disease or simple epistaxis. OBJECTIVES: The aims of the present study are to determine the relative incidence of benign tumor of the nasal cavity and to provide typical endoscopic features of common tumors...
February 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28168747/double-paddle-peroneal-flap-for-extensive-lip-defect-reconstruction
#8
Ying-Sheng Lin, Wen-Chung Liu, Yaoh-Shiang Lin, Lee-Wei Chen, Jung-Hua Hsueh, Kuo-Chung Yang
INTRODUCTION: Today, reconstructive surgeons offer an array of options to reconstruct the lip defects. Herein we present our experience of using free double-paddle peroneal flaps for extensive lip defect reconstruction. PATIENTS AND METHODS: From 1996 to 2014, 16 patients with extensive lip defects after tumor ablation were included. Free double-paddle peroneal flaps were used for reconstructions. In terms of flap design, one skin paddle superiorly placed on the lateral lower leg was used to reconstruct intraoral defects, whereas the other was inferiorly located and was used to reconstruct extraoral defects...
February 7, 2017: Microsurgery
https://www.readbyqxmd.com/read/28165045/%C3%AE-1-and-%C3%AE-2-adrenergic-stimulation-induced-electrogenic-transport-by-human-endolymphatic-sac-epithelium-and-its-clinical-implications
#9
Bo Gyung Kim, Jin Young Kim, JinSei Jung, In Seok Moon, Joo-Heon Yoon, Jae Young Choi, Sung Huhn Kim
The endolymphatic sac (ES) is a cystic structure of the inner ear connected to the cochlea and vestibule, which plays a role in regulating ion homeostasis in inner ear fluid. Disruption of ion homeostasis can cause inner ear disorders with hearing loss and dizziness, such as Meniere's disease. Herein, we found, for the first time, functional evidence for the involvement of β1- and β2-adrenergic receptors in apical electrogenic ion transport by human ES epithelium by using electrophysiological/pharmacological and molecular biological methods, which were dependent on K(+) and Cl(-) ion transport...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28154359/impairments-of-inner-ears-caused-by-physical-environmental-stresses
#10
Nobutaka Ohgami, Reina Oshino, Hiromasa Ninomiya, Xiang Li, Masashi Kato
The inner ears contain the organ of Corti, vestibule and semicircular canal. The organ of Corti is crucial for hearing, while the vestibule and semicircular canal play important roles in maintaining balance. Exposure to noise at excessive levels is known to cause damages of the inner ears, resulting in noise-induced hearing loss. On the other hand, noise levels (dB) are used for the evaluation of health risks by exposure to noise, although noise consists of sound with broad frequencies (Hz). Thus, information about the frequency-dependent effect of noise on health is largely unknown...
2017: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/28149809/transoral-endoscopic-thyroidectomy-via-vestibular-approach-operative-steps-and-video
#11
Gianlorenzo Dionigi, Alessandro Bacuzzi, Matteo Lavazza, Davide Inversini, Vincenzo Pappalardo, Luigi Boni, Stefano Rausei, Marcin Barczynski, Ralph P Tufano, Hoon Yub Kim, Angkoon Anuwong
In this video we describe transoral endoscopic thyroidectomy vestibular approach (TOETVA). Inclusion criteria are (I) patients who had a ultrasonographically (US) estimated thyroid diameter not larger than 10 cm; (II) US estimated gland volume ≤45 mL; (III) nodule size ≤50 mm; (IV) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (V) follicular neoplasm; (VI) papillary microcarcinoma without evidence of metastasis. The procedure is carried out through three-port technique placed at the oral vestibule, one 10-mm port for 30° endoscope and two additional 5-mm ports for dissecting and coagulating instruments...
December 2016: Gland Surgery
https://www.readbyqxmd.com/read/28149798/transoral-endoscopic-thyroidectomy-vestibular-approach-toetva-for-graves-disease-a-comparison-of-surgical-results-with-open-thyroidectomy
#12
Pornpeera Jitpratoom, Khwannara Ketwong, Thanyawat Sasanakietkul, Angkoon Anuwong
BACKGROUND: Transoral endoscopic thyroidectomy vestibular approach (TOETVA) provides excellent cosmetic results from its potential for scar-free operation. The procedure has been applied successfully for Graves' disease by the authors of this work and compared with the standard open cervical approach to evaluate its safety and outcomes. METHODS: From January 2014 to November 2016, a total of 97 patients with Graves' disease were reviewed retrospectively. Open thyroidectomy (OT) and TOETVA were performed in 49 patients and 46 patients, respectively...
December 2016: Gland Surgery
https://www.readbyqxmd.com/read/28143570/host-genetic-variation-in-mucosal-immunity-pathways-influences-the-upper-airway-microbiome
#13
Catherine Igartua, Emily R Davenport, Yoav Gilad, Dan L Nicolae, Jayant Pinto, Carole Ober
BACKGROUND: The degree to which host genetic variation can modulate microbial communities in humans remains an open question. Here, we performed a genetic mapping study of the microbiome in two accessible upper airway sites, the nasopharynx and the nasal vestibule, during two seasons in 144 adult members of a founder population of European decent. RESULTS: We estimated the relative abundances (RAs) of genus level bacteria from 16S rRNA gene sequences and examined associations with 148,653 genetic variants (linkage disequilibrium [LD] r (2) < 0...
February 1, 2017: Microbiome
https://www.readbyqxmd.com/read/28112730/cotranslational-folding-of-spectrin-domains-via-partially-structured-states
#14
Ola B Nilsson, Adrian A Nickson, Jeffrey J Hollins, Stephan Wickles, Annette Steward, Roland Beckmann, Gunnar von Heijne, Jane Clarke
How do the key features of protein folding, elucidated from studies on native, isolated proteins, manifest in cotranslational folding on the ribosome? Using a well-characterized family of homologous α-helical proteins with a range of biophysical properties, we show that spectrin domains can fold vectorially on the ribosome and may do so via a pathway different from that of the isolated domain. We use cryo-EM to reveal a folded or partially folded structure, formed in the vestibule of the ribosome. Our results reveal that it is not possible to predict which domains will fold within the ribosome on the basis of the folding behavior of isolated domains; instead, we propose that a complex balance of the rate of folding, the rate of translation and the lifetime of folded or partly folded states will determine whether folding occurs cotranslationally on actively translating ribosomes...
January 23, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28112062/the-doyle-saleh-blink-reflex
#15
P W Doyle, I Beegun, H A Saleh
OBJECTIVES: When performing septoplasty or septorhinoplasty, we have observed that patients blink on injection of local anaesthetic (lidocaine 1 per cent with adrenaline 1:80 000) into the nasal mucosa of the anterior septum or vestibular skin, despite appropriate general anaesthesia. This study sought to quantify this phenomenon by conducting a prospective audit of all patients undergoing septoplasty or septorhinoplasty. METHODS: Patients were observed for a blink reflex at the time of local anaesthetic infiltration into the nasal vestibule...
January 23, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28110919/effect-of-topical-anesthesia-on-pain-from-needle-insertion-and-injection-and-its-relationship-with-anxiety-in-patients-awaiting-apical-surgery-a%C3%A2-randomized-double-blind-clinical-trial
#16
Sin-Yeon Cho, Euiseong Kim, Sung-Ho Park, Byoung-Duck Roh, Chan-Young Lee, Seung-Jong Lee, Il-Young Jung
INTRODUCTION: We aimed to simultaneously investigate the effects of topical anesthesia on needle insertion and injection pain in the labial mucosa of the maxillary central incisors of patients awaiting apical surgery and to assess the relationship between patients' anxiety and pain scores. METHODS: Forty-four patients scheduled for apical surgery of the maxillary anterior incisor or canine were included, and all completed the Modified Dental Anxiety Scale (MDAS) questionnaire...
January 19, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28109485/ampleness-of-head-movements-of-children-and-adolescents-with-sensorineural-hearing-loss
#17
Renato de Souza Melo
INTRODUCTION: Head movements are controlled by the vestibular system. Children with sensorineural hearing loss can present restrictions in ampleness of head movements due to damage in the vestibule-cochlear systems, resulting from injury in the inner ear. OBJECTIVE: To evaluate the ampleness of head movements of children with normal hearing and children with sensorineural hearing loss and compare data between groups. METHODS: Cross-sectional study that evaluated the ampleness of head movements of 96 students, being 48 with normal hearing and 48 with sensorineural hearing loss, of both sexes, with aged between 7 and 18 years old...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28068300/early-postoperative-imaging-of-the-labyrinth-by-cone-beam-ct-after-stapes-surgery-for-otosclerosis-with-correlation-to-audiovestibular-outcome
#18
Aurélie Vandevoorde, Marc T Williams, Elsa Ukkola-Pons, Mary Daval, Denis Ayache
BACKGROUND: Sensorineural complications of stapes surgery are rare but potentially serious. Imaging is usually performed to identify an underlying cause, such as excessive intravestibular penetration of the prosthesis or pneumolabyrinth suggesting perilymphatic fistula. Unfortunately, there is very little data in an unselected series of uneventful patients.The aim of this study was to analyze the depth of prosthesis penetration within the vestibule and the rate of pneumolabyrinth the day or the day after the procedure by performing a cone beam computed tomography of the temporal bone in a cohort of unselected patients, and to correlate imaging findings to clinical outcome...
February 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28062309/a-local-inflammatory-renin-angiotensin-system-drives-sensory-axon-sprouting-in-provoked-vestibulodynia
#19
Zhaohui Liao, Anuradha Chakrabarty, Ying Mu, Aritra Bhattacherjee, Martha Goestch, Catherine M Leclair, Peter G Smith
: Vestibulodynia is a form of provoked vulvodynia characterized by profound tenderness, hyperinnervation, and frequently inflammation within well-defined areas of the human vestibule. Previous experiments in animal models show that inflammatory hypersensitivity and hyperinnervation occur in concert with establishment of a local renin-angiotensin system (RAS). Moreover, mechanical hypersensitivity and sensory axon sprouting are prevented by blocking effects of angiotensin II on angiotensin II receptor type 2 (AT2) receptors...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28050646/gentamicin-applied-to-the-oval-window-suppresses-vestibular-function-in-guinea-pigs
#20
E B King, R K Shepherd, D J Brown, J B Fallon
Intratympanic gentamicin therapy is widely used clinically to treat the debilitating symptoms of Ménière's disease. Cochleotoxicity is an undesirable potential side effect of the treatment and the risk of hearing loss increases proportionately with gentamicin concentration in the cochlea. It has recently been shown that gentamicin is readily absorbed through the oval window in guinea pigs. The present study uses quantitative functional measures of vestibular and cochlea function to investigate the efficacy of treating the vestibule by applying a small volume of gentamicin onto the stapes footplate in guinea pigs...
January 3, 2017: Journal of the Association for Research in Otolaryngology: JARO
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