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https://www.readbyqxmd.com/read/29664498/-hypophosphatemia-in-preterm-infants-a-bimodal-disorder
#1
María Paz Cubillos Celis, Patricia Mena Nannig
New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29659865/effects-of-a-multi-element-trace-mineral-injection-and-vitamin-e-supplementation-on-performance-carcass-characteristics-and-color-stability-of-strip-steaks-from-feedlot-heifers
#2
B N Harsh, A C Dilger, D D Boler, D W Shike
The objective was to evaluate the interaction of a trace mineral (TM) injection (Multimin 90) and a supranutritional concentration of dietary vitamin E (VITE) on performance, carcass characteristics and color stability of strip steaks from feedlot heifers. Prior to trial initiation, Angus × Simmental cross heifers (N = 48) were managed on a common diet supplemented to meet NRC recommendations (NRC, 2000). Heifers were stratified by BW and allotted to a 2 x 2 factorial arrangement: 1) no supplemental vitamin E and saline injection (CONT+SAL), 2) 1000 IU vitamin E/heifer·d-1 and saline injection (VITE+SAL), 3) no supplemental vitamin E and TM injection (CONT+MM), or 4) vitamin E and TM injection (VITE+MM)...
April 5, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29628721/a-cross-sectional-study-to-assess-and-correlate-osteoporosis-and-periodontitis-among-postmenopausal-women-a-dual-energy-x-ray-absorptiometry-study
#3
Vaishali Narayan Mashalkar, Girish Suragimath, Sameer Anil Zope, Siddhartha A Varma
Background: Periodontitis and osteoporosis are two diseases found worldwide and increase in intensity with increasing age of the patients. The severity of osteoporosis and periodontitis are found to be more in women during menopause. The aim of this study was to assess and correlate osteoporosis and periodontal disease among post-menopausal women. Materials and Methods: The study consisted of 94 postmenopausal women in the age range of 45-65 years. All the women underwent dual-energy X-ray absorptiometry (DXA) scan to measure bone mineral density (BMD) and were graded as normal, osteopenic, and osteoporotic based on the T score obtained...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29617962/assessment-of-the-minimal-available-phosphorus-needs-of-laying-hens-implications-for-phosphorus-management-strategies
#4
M Jing, S Zhao, A Rogiewicz, B A Slominski, J D House
The oversupply of dietary phosphorus (P) leads to increased feed costs and discharge of excessive P to the environment, thus directly impacting the sustainability of egg production practices. The present study was conducted to better define the minimal available P needs of laying hens. Fifty-six Lohmann white laying hens were individually caged and fed one of 7 diets with graded levels of available P (0.15, 0.20, 0.25, 0.30, 0.35, 0.40, or 0.45%) for 12 weeks. Records were maintained for body weight, feed intake, and egg production during the experimental period...
March 28, 2018: Poultry Science
https://www.readbyqxmd.com/read/29617666/systematic-analysis-of-splice-site-creating-mutations-in-cancer
#5
Reyka G Jayasinghe, Song Cao, Qingsong Gao, Michael C Wendl, Nam Sy Vo, Sheila M Reynolds, Yanyan Zhao, Héctor Climente-González, Shengjie Chai, Fang Wang, Rajees Varghese, Mo Huang, Wen-Wei Liang, Matthew A Wyczalkowski, Sohini Sengupta, Zhi Li, Samuel H Payne, David Fenyö, Jeffrey H Miner, Matthew J Walter, Benjamin Vincent, Eduardo Eyras, Ken Chen, Ilya Shmulevich, Feng Chen, Li Ding
For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of splice-site-creating mutations (SCMs) across 8,656 TCGA tumors. We report 1,964 originally mis-annotated mutations having clear evidence of creating alternative splice junctions. TP53 and GATA3 have 26 and 18 SCMs, respectively, and ATRX has 5 from lower-grade gliomas. Mutations in 11 genes, including PARP1, BRCA1, and BAP1, were experimentally validated for splice-site-creating function...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29609151/development-of-copper-recovery-process-from-flotation-tailings-by-a-combined-method-of-high%C3%A2-pressure-leaching%C3%A2-solvent-extraction
#6
Baisui Han, Batnasan Altansukh, Kazutoshi Haga, Zoran Stevanović, Radojka Jonović, Ljiljana Avramović, Daniela Urosević, Yasushi Takasaki, Nobuyuki Masuda, Daizo Ishiyama, Atsushi Shibayama
Sulfide copper mineral, typically Chalcopyrite (CuFeS2 ), is one of the most common minerals for producing metallic copper via the pyrometallurgical process. Generally, flotation tailings are produced as a byproduct of flotation and still consist of un‒recovered copper. In addition, it is expected that more tailings will be produced in the coming years due to the increased exploration of low‒grade copper ores. Therefore, this research aims to develop a copper recovery process from flotation tailings using high‒pressure leaching (HPL) followed by solvent extraction...
March 19, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29605718/a-novel-mouse-model-of-intervertebral-disc-degeneration-shows-altered-cell-fate-and-matrix-homeostasis
#7
Hyowon Choi, Steven Tessier, Elizabeth S Silagi, Rutvin Kyada, Farzad Yousefi, Nancy Pleshko, Irving M Shapiro, Makarand V Risbud
Intervertebral disc degeneration and associated low back and neck pain is a ubiquitous health condition that affects millions of people world-wide, and causes high incidence of disability and enormous medical/societal costs. However, lack of appropriate small animal models with spontaneous disease onset has impeded our ability to understand the pathogenetic mechanisms that characterize and drive the degenerative process. We report, for the first time, early onset spontaneous disc degeneration in SM/J mice known for their poor regenerative capacities compared to "super-healer" LG/J mice...
March 29, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29601923/evaluation-and-management-of-testosterone-deficiency-aua-guideline
#8
John P Mulhall, Landon W Trost, Robert E Brannigan, Emily G Kurtz, J Bruce Redmon, Kelly A Chiles, Deborah J Lightner, Martin M Miner, M Hassan Murad, Christian J Nelson, Elizabeth A Platz, Lakshmi V Ramanathan, Ronald W Lewis
PURPOSE: There has been a marked increase in testosterone prescriptions in the past decade resulting in a growing need to give practicing clinicians proper guidance on the evaluation and management of the testosterone deficient patient. MATERIALS & METHODS: A systematic review utilized research from the Mayo Clinic Evidence Based Practice Center and additional supplementation by the authors. Evidence-based statements were based on body of evidence strength Grade A, B, or C and were designated as Strong, Moderate, and Conditional Recommendations with additional statements presented in the form of Clinical Principles or Expert Opinions...
March 27, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29575452/bioactivity-of-novel-functionally-structured-titanium-ceramic-composites-in-contact-with-human-osteoblasts
#9
G M Peñarrieta-Juanito, M Costa, M Cruz, G Miranda, B Henriques, J Marques, R S Magini, A Mata, J Caramês, Fs F Silva, Jcm Souza
The aim of this study was to analyze the osteogenic cell behavior on the surface of novel functionally graded titanium-based composites containing bioactive ceramics. Titanium grade V discs (8 x 3 mm) embedding gradual content of hydroxyapatite (TiAlV-HA) or beta-tricalcium phosphate (TiAlV-βTCP) were produced by hot-pressing technique. Titanium-ceramic composite discs and Ti grade V (control group) were placed in contact with human osteoblast culture assays. The morphology and adhesion of osteoblasts were inspected by field emission guns scanning electron microscopy (FEGSEM) while cell viability was assessed by fluorometric method...
March 25, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29562263/effect-of-supplementation-of-phytase-to-diets-low-in-inorganic-phosphorus-on-growth-performance-and-mineralization-of-broilers
#10
D V Scholey, N K Morgan, A Riemensperger, R Hardy, E J Burton
There has been discussion regarding microbial phytase replacing inorganic phosphorus (P) supplementation in broiler diets. Therefore, an experiment was conducted to examine the effect of phytase supplementation on diets low in inorganic P. Ross 308 broilers (n = 288) were fed one of 6 experimental diets in 4 phases. The control diet had 16.20, 10.90, 9.40, and 6.10 g/kg inorganic P in the Starter, Grower 1, Grower 2 and Finisher phase respectively. The remaining diets had 10.50 g/kg inorganic P in the Starter phase...
March 16, 2018: Poultry Science
https://www.readbyqxmd.com/read/29555612/the-optimal-volume-fraction-in-percutaneous-vertebroplasty-evaluated-by-pain-relief-cement-dispersion-and-cement-leakage-a-prospective-cohort-study-of-130-patients-with-painful-osteoporotic-vertebral-compression-fracture-in-the-thoracolumbar-vertebra
#11
Hai-Bo Sun, Xiao-Shan Jing, Yu-Zeng Liu, Ming Qi, Xin-Kuan Wang, Yong Hai
OBJECTIVE: Our aim was to probe the relationship among cement volume/fraction, imaging features of cement distribution, and pain relief, and then to evaluate the optimal volume during percutaneous vertebroplasty. METHODS: From January 2014 to January 2017, a total of 130 patients eligible for inclusion criteria were enrolled in this prospective cohort study. According to the different degrees of pain relief, cement leakage, and cement distribution, all patients were allocated to 2 groups...
March 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29537945/efficacy-of-platelet-concentrates-in-pulpotomy-a-systematic-review
#12
Roshan Noor Mohamed, Sakeenabi Basha, Yousef Al-Thomali
The main purpose of the present systematic review was to evaluate the efficacy of platelet concentrates in pulpotomy of human teeth. Our systematic search included Medline, Embase, CINAHL, PsycINFO, Scopus, key journals, and review articles; the date of the last search was July 30, 2017. We graded the methodological quality of the studies by Cochrane Risk of Bias tool. Four randomized controlled trails were included in the present systematic review. The number of study participants ranged from 28 to 50, with a mean of 45...
March 14, 2018: Platelets
https://www.readbyqxmd.com/read/29530627/consensus-document-on-osteoporosis-in-males
#13
Mariela Varsavsky, Manuel Romero Muñoz, Verónica Ávila Rubio, Antonio Becerra, Antonia García Martín, Guillermo Martínez Díaz-Guerra, Pedro Rozas Moreno, Esteban Jódar Gimeno, Manuel Muñoz Torres
OBJECTIVE: To provide practical recommendations to assess and treat osteoporosis in males. PARTICIPANTS: Members of the Bone Metabolism Working Group of the Spanish Society of Endocrinology. METHODS: Recommendations were formulated using the GRADE system (Grading of Recommendations, Assessment, Development, and Evaluation) to describe both the strength of recommendations and the quality of evidence. A systematic search was made in Medline (PubMed) using the following associated terms: «osteoporosis», «men», «fractures», «bone mineral density», «treatment», «hypogonadism», and «prostate cancer»...
March 2018: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/29520506/effects-of-denosumab-on-bone-mineral-density-in-japanese-women-with-osteoporosis-treated-with-aromatase-inhibitors-for-breast-cancer
#14
Katsuhiko Nakatsukasa, Hiroshi Koyama, Yoshimi Ouchi, Kouichi Sakaguchi, Yoshifumi Fujita, Takayuki Matsuda, Makoto Kato, Eiichi Konishi, Tetsuya Taguchi
Adjuvant aromatase inhibitor (AI) therapy, for hormone receptor-positive breast cancer, in postmenopausal women is associated with bone loss, leading to an increased risk of fractures. Denosumab, an antibody raised against the receptor activator of nuclear factor-κB ligand, has been proven to protect against AI-induced bone loss. Hence, we aimed to determine whether denosumab is effective in postmenopausal Japanese women with osteoporosis, treated with AI. We prospectively evaluated the bone mineral density (BMD) in the lumbar spine and the bilateral femoral neck in 102 postmenopausal women with clinical hormone receptor-positive breast cancer, stages I-IIIA, during a postoperative period of 12 months...
March 8, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29519425/strontium-modification-of-porous-scaffolds-from-mineralized-collagen-for-potential-use-in-bone-defect-therapy
#15
Mandy Quade, Matthias Schumacher, Anne Bernhardt, Anja Lode, Marian Kampschulte, Andrea Voß, Paul Simon, Ortrud Uckermann, Matthias Kirsch, Michael Gelinsky
The present study describes the development and characterization of strontium(II)-modified biomimetic scaffolds based on mineralized collagen type I as potential biomaterial for the local treatment of defects in systemically impaired (e.g. osteoporotic) bone. In contrast to already described collagen/hydroxyapatite nanocomposites calcium was substituted with strontium to the extent of 25, 50, 75 and 100mol% by substituting the CaCl2 -stock solution (0.1M) with SrCl2 (0.1M) during the scaffold synthesis. Simultaneous fibrillation and mineralization of collagen led to the formation of collagen-mineral nanocomposites with mineral phases shifting from nanocrystalline hydroxyapatite (Sr0) over poorly crystalline Sr-rich phases towards a mixed mineral phase (Sr100), consisting of an amorphous strontium phosphate (identified as Collin's salt, Sr6 H3 (PO4 )5 ∗2 H2 O, CS) and highly crystalline strontium hydroxyapatite (Sr5 (PO4 )3 OH, SrHA)...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29513906/does-inflammation-affect-outcomes-in-dialysis-patients
#16
Kristen L Nowak, Michel Chonchol
Chronic, low-grade inflammation is a common comorbid condition in chronic kidney disease (CKD), and particularly in chronic dialysis patients. In this review, we consider the question of whether inflammation affects outcomes in dialysis patients. Levels of proinflammatory cytokines, as well as C-reactive protein, are elevated in chronic dialysis patients. Multiple factors likely contribute to chronic inflammatory activation in kidney disease patients including the uremic milieu, lifestyle and epigenetic influences, infectious and thrombotic events, the dialysis process, and dysbiosis...
March 7, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29510951/treatment-of-high-grade-acetabular-defects-do-porous-titanium-cups-provide-better-stability-than-traditional-titanium-cups-when-combined-with-an-augment
#17
Nicholas A Beckmann, Rudi G Bitsch, Maciej B Janoszka, Matthias C Klotz, Thomas Bruckner, Sebastian Jaeger
BACKGROUND: Revision total hip arthroplasty frequently faces challenges associated with deficient bone stock. Porous metal implants were developed to meet the challenge, but require rapid osseointegration for ultimate success. This study aims to assess relative motion as an indicator for primary stability and osseointegration of two different titanium cups each combined with a titanium augment. METHODS: In 14 cadaver hemipelvises, 2 types of titanium acetabular cups, a traditional sintered-bead cup (POROCOAT Acetabular Cup [PAC]) and a newer porous-coated cup (GRIPTION Acetabular Cup [GAC]) each associated with a porous augment, were subjected to 3-dimensional varying loads, replicating 30% of loads experienced during normal gait...
February 5, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29504223/consensus-guidelines-on-the-use-of-bisphosphonate-therapy-in-children-and-adolescents
#18
Peter J Simm, Andrew Biggin, Margaret R Zacharin, Christine P Rodda, Elaine Tham, Aris Siafarikas, Craig Jefferies, Paul L Hofman, Diane E Jensen, Helen Woodhead, Justin Brown, Benjamin J Wheeler, Denise Brookes, Antony Lafferty, Craig F Munns
Bisphosphonate therapy is the mainstay of pharmacological intervention in young people with skeletal fragility. The evidence of its use in a variety of conditions remains limited despite over three decades of clinical experience. On behalf of the Australasian Paediatric Endocrine Group, this evidence-based consensus guideline presents recommendations and discusses the graded evidence (using the GRADE system) for these recommendations. Primary bone fragility disorders such as osteogenesis imperfecta are considered separately from osteoporosis secondary to other clinical conditions (such as cerebral palsy, Duchenne muscular dystrophy)...
March 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29502131/clinical-radiological-and-pathological-features-of-extraskeletal-osteosarcoma
#19
Lauren A Roller, Ivan Chebib, Miriam A Bredella, Connie Y Chang
OBJECTIVE: To evaluate clinical and radiological features of pathology-proven extraskeletal osteosarcomas. METHODS: This retrospective study was IRB-approved and HIPAA-compliant. Our pathology database was queried for cases of extraskeletal osteosarcoma. Tumor location, size, imaging appearance, presence of metastases, and clinical outcome were documented. RESULTS: Nineteen patients met inclusion criteria (age 59 ± 15 (range 28-85) years; 15 male, 4 female)...
March 3, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29489823/diet-during-pregnancy-and-infancy-and-risk-of-allergic-or-autoimmune-disease-a-systematic-review-and-meta-analysis
#20
Vanessa Garcia-Larsen, Despo Ierodiakonou, Katharine Jarrold, Sergio Cunha, Jennifer Chivinge, Zoe Robinson, Natalie Geoghegan, Alisha Ruparelia, Pooja Devani, Marialena Trivella, Jo Leonardi-Bee, Robert J Boyle
BACKGROUND: There is uncertainty about the influence of diet during pregnancy and infancy on a child's immune development. We assessed whether variations in maternal or infant diet can influence risk of allergic or autoimmune disease. METHODS AND FINDINGS: Two authors selected studies, extracted data, and assessed risk of bias. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess certainty of findings. We searched Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE), Web of Science, Central Register of Controlled Trials (CENTRAL), and Literatura Latino Americana em Ciências da Saúde (LILACS) between January 1946 and July 2013 for observational studies and until December 2017 for intervention studies that evaluated the relationship between diet during pregnancy, lactation, or the first year of life and future risk of allergic or autoimmune disease...
February 2018: PLoS Medicine
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