Kenneth Lundstrom, Altijana Hromić-Jahjefendić, Esma Bilajac, Alaa A A Aljabali, Katarina Baralić, Nagwa A Sabri, Eslam M Shehata, Mohamed Raslan, Ana Cláudia B H Ferreira, Ángel Serrano-Aroca, Murtaza M Tambuwala, Vladimir N Uversky, Vasco Azevedo, Khalid J Alzahrani, Khalaf F Alsharif, Ibrahim F Halawani, Fuad M Alzahrani, Debmalya Barh
The COVID-19 pandemic has been the focus of research the past two years. The major breakthrough was made by discovering pathways related to SARS-CoV-2 infection through cellular interaction by angiotensin-converting enzyme ACE2 and cytokine storm. The presence of ACE2 in lungs, intestines, cardiovascular tissues, brain, kidneys, liver, and eyes shows that SARS-CoV-2 may have targeted these organs to further activate intracellular signalling pathways that lead to cytokine release syndrome. It has also been reported that SARS-CoV-2 can hijack coatomer protein-I (COPI) for S protein retrograde trafficking to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC), which, in turn, acts as the assembly site for viral progeny...
October 14, 2022: Cellular Signalling