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M Port, B Pieper, T Knie, H Dörr, A Ganser, D Graessle, V Meineke, M Abend
Rapid clinical triage of radiation injury patients is essential for determining appropriate diagnostic and therapeutic interventions. We examined the utility of blood cell counts (BCCs) in the first three days postirradiation to predict clinical outcome, specifically for hematologic acute radiation syndrome (HARS). We analyzed BCC test samples from radiation accident victims (n = 135) along with their clinical outcome HARS severity scores (H1-4) using the System for Evaluation and Archiving of Radiation Accidents based on Case Histories (SEARCH) database...
August 2017: Radiation Research
Heejin Kim, Keita Inoue, Jun-Ichi Yoshida
A series of anionic Fries-type rearrangements of carbamoyl-substituted aryllithium intermediates were controlled by using flow microreactor systems. For the [1,4] and [1,5] rearrangements, the aryllithium intermediate formed before carbamoyl migration and the lithium alkoxide formed after carbamoyl migration can be selectively subjected to subsequent reactions with electrophiles by precisely controlling the residence time and temperature (-25 to -50 °C). In contrast, the [1,6] rearrangement is rather slow even at -25 °C...
June 26, 2017: Angewandte Chemie
Chao Nan Wang, Jian Jun Chen, Jin Feng Zhou, Hui Bin Tang, Yan Bo Feng, Xianhong Yi
Bryant traction is a commonly used method for femoral shaft fractures in children, but many disadvantages have been reported. Pavlik harness with exact clinical effect and fewer complications has gained increasing popularity in resent years. The objective of this study was to evaluate and compare modified Pavlik harness with Bryant traction for infant with a femoral shaft fracture. A retrospective study was performed of 38 infants treated with either modified Pavlik Harness or Bryant traction. All fractures were closed, isolated, and diaphyseal...
March 2014: Acta Orthopaedica Belgica
Mostafa Taoufik, Kai C Szeto, Nicolas Merle, Iker Del Rosal, Laurent Maron, Julien Trébosc, Grégory Tricot, Régis M Gauvin, Laurent Delevoye
The surface hydroxyl groups of γ-alumina dehydroxylated at 500 °C were studied by a combination of one- and two-dimensional homo- and heteronuclear (1)H and (27)Al NMR spectroscopy at high magnetic field. In particular, by harnessing (1)H-(27) Al dipolar interactions, a high selectivity was achieved in unveiling the topology of the alumina surface. The terminal versus bridging character of the hydroxyl groups observed in the (1)H magic-angle spinning (MAS) NMR spectrum was demonstrated thanks to (1)H-(27) Al RESPDOR (resonance-echo saturation-pulse double-resonance)...
April 1, 2014: Chemistry: a European Journal
A M Prior, M Thapa, D H Hua
Nanotechnology is a rapidly emerging drug-delivery system that makes possible the controlled release of small molecules, and nanodelivery of therapeutic molecules using nanoparticles or nanogels represents a major improvement for more focused delivery of such therapeutic molecules. The delivery of insulin for the control of diabetes mellitus (DM) and aldose reductase inhibitor (ARI) for diabetic complications may provide better treatment of diabetes. A structural overview of aldose reductase including computational docking experiments with HAR-1, various ARIs, aldose-keto reductase, and nanodelivery of insulin, ARI's, and drug molecules are described...
April 2012: Mini Reviews in Medicinal Chemistry
M F Alam, Mohammed M Safhi, A K Chopra, V K Dua
The leaves of five plants namely Nyctanthes arbortistis (Oleaceae), Catharanthus roseus (Apocynaceae), Boenininghusenia albiflora (Rutaceae), Valeriana hardwickii (Valerianaceae) and Eupatorium odoratum (Asteraceae) were selected for the first time from the Garhwal region of north west Himalaya to investigation its toxicological properties against mosquito vectors of malaria, filariasis and dengue. In a laboratory study, using different polarity solvents (petroleum ether, chloroform and methanol) were tested against important larvae of malaria, filariasis and dengue vectors in India...
August 2011: Tropical Biomedicine
Sarah B Pierce, Karen M Chisholm, Eric D Lynch, Ming K Lee, Tom Walsh, John M Opitz, Weiqing Li, Rachel E Klevit, Mary-Claire King
Perrault syndrome is a genetically heterogeneous recessive disorder characterized by ovarian dysgenesis and sensorineural hearing loss. In a nonconsanguineous family with five affected siblings, linkage analysis and genomic sequencing revealed the genetic basis of Perrault syndrome to be compound heterozygosity for mutations in the mitochondrial histidyl tRNA synthetase HARS2 at two highly conserved amino acids, L200V and V368L. The nucleotide substitution creating HARS2 p.L200V also created an alternate splice leading to deletion of 12 codons from the HARS2 message...
April 19, 2011: Proceedings of the National Academy of Sciences of the United States of America
Iryna O Zubovych, Sarah Straud, Michael G Roth
In a previous genetic screen for Caenorhabditis elegans mutants that survive in the presence of an antimitotic drug, hemiasterlin, we identified eight strong mutants. Two of these were found to be resistant to multiple toxins, and in one of these we identified a missense mutation in phb-2, which encodes the mitochondrial protein prohibitin 2. Here we identify two additional mutations that confer drug resistance, spg-7 and har-1, also in genes encoding mitochondrial proteins. Other mitochondrial mutants, isp-1, eat-3, and clk-1, were also found to be drug-resistant...
March 15, 2010: Molecular Biology of the Cell
Sjaanie Koppel, Judith L Charlton
OBJECTIVE: Motor vehicle crashes are one of the leading causes of child death and acquired disability. Child restraint systems (CRS) for vehicles are designed to provide specialized protection for child occupants in the event of a crash. However, the effectiveness of a CRS is critically dependent on: correct installation of the CRS in the vehicle, the correct harnessing of the child in the CRS, and use of an appropriate CRS. The current study aimed to investigate the incidence misuse and/or inappropriate use of CRS through a CRS inspection program in the Australian states of New South Wales (NSW), Victoria (VIC), Queensland (QLD), South Australia (SA), Western Australia (WA), and Tasmania (TAS)...
June 2009: Traffic Injury Prevention
Milos Pajić, Zoran Vukasinović
INTRODUCTION: A clinical examination of a newborn infant is indispensable, but certainly insufficient for a diagnosis of developmental deformity of the hip (DDH) to be made. The use of the ultrasound in the diagnostics of DDH, beside the visualization and making the respective clinical findings objective, made possible verification (still without a distinction of the tissues) of the two basic categories of the primary condition of a newborn baby hips. OBJECTIVE: The purpose of this study was to find out the optimal methodological procedure for the early detection of DDH in newborn infants and sucklings...
July 2007: Srpski Arhiv za Celokupno Lekarstvo
Dolores J Takemoto, Richard Harris, Al Brightman, John McGill, Duy Hua, Harriet Davidson, Brad Fenwick, Lynn M Wagner
The purpose of this study was to determine the effects of a novel aldose reductase inhibitor on lens protein kinase Cgamma (PKCgamma) levels in galactosemic dogs. Six-month old Beagles (12 total; 6 male and 6 female) were made galactosemic by feeding a diet of 40% galactose for 6 weeks. Three dogs per group were fed either control, normal diet, 40% galactose diet, 40% galactose diet with aldose reductase inhibitor at 100 mg/kg body weight per day given orally, or a control diet with aldose reductase inhibitor alone (1-H,7-H-5alpha,6,8,9-tetrahydro-1-oxopyran[4,3-beta](1) benzopyran, referred to herein as HAR-1)...
May 2004: Veterinary Ophthalmology
Antonio Lobo, Lorenzo Chamorro, Antonio Luque, Rafael Dal-Ré, Xavier Badia, Eva Baró
BACKGROUND: Affective and anxiety disorders (AfD & AnD) are the most common psychiatric diseases in the general population. This study's aim was to assess for the first time the psychometric properties of the Spanish translated versions of the Montgomery-Asberg Depression Rating Scale (MADRS) and the Hamilton Anxiety Rating Scale (HARS), which are widely used both in medical care and clinical research. PATIENTS AND METHOD: A cohort, observational, prospective and multicentre study was conducted in clinically stable or unstable patients with AfD and AnD...
April 13, 2002: Medicina Clínica
S Lewis, J Karrer, S Saleh, X Chan, Z Tan, D Hua, J McGill, Y P Pang, B Fenwick, A Brightman, D Takemoto
PURPOSE: To synthesize novel aldose reductase inhibitors (ARI) that will normalize losses in protein kinase Cgamma (PKCgamma) observed during diabetes and galactosemia. METHODS: ARI were synthesized as tricyclic pyrones 1-6 (HAR-1 through HAR-6) from 3-methyl-1H,7H-5a,6,8,9-tetrahydro-1-oxopyrano[4,3-b][1]benzopyran and (5aS,7S)-7-isopropenyl-3-methyl-1H,7H-5a,6,8,9-tetrahydro-1-oxopyrano[4,3-b][1]benzopyran and were tested by inhibition of aldose reductase enzyme activity in vitro and by inhibition of polyol formation in lens epithelial cells in culture...
July 18, 2001: Molecular Vision
D C Borie, D V Cramer, H Shirwan, G D Wu, L Hannoun, L Makowka
The early phases of the rejection of xenografts exchanged between closely-related species are dominated by a vigorous humoral immune response. We have recently used a linkermediated polymerase chain reaction to generate Ig heavy and light chain specific cDNA libraries to examine the Ig gene control of a prototypic IgM monoclonal antibody, HAR-1, that causes the hyperacute rejection of hamster xenografts. Recombinant clones from the library were screened directly from bacterial colonies by PCR and the nucleic acid sequences of the clones established...
1996: Chirurgie; Mémoires de L'Académie de Chirurgie
A J Griffiths, X Yang
A strain of Neurospora intermedia from China contains five prominent extragenomic mitochondrial plasmids: three linear elements called zhisi plasmids, and two circular plasmids, Harbin-1 and -2. In one subculture, levels of four plasmids (all three zhisis and Harbin-1) fell to undetectable values and two novel linear plasmids appeared, Harbin-L and -L2, as well as a new small circular plasmid, Harbin-0.9. Cross-hybridization of restriction fragments and DNA sequencing showed that the Harbin-L plasmid was composed of parts of the circular Harbin-1 plasmid and of one of the linear zhisi plasmids...
November 1, 1995: Molecular & General Genetics: MGG
D C Borie, D V Cramer, H Shirwan, G D Wu, O Rodriguez, F A Chapman, L Makowka
The early phases of the rejection of xenografts exchanged between closely related species are dominated by a vigorous humoral immune response. We have recently used a linker-mediated polymerase chain reaction (LM-PCR) to generate Ig heavy and light chain-specific cDNA libraries to examine the Ig gene control of a prototypic IgM monoclonal antibody, HAR-1, that causes the hyperacute rejection of hamster xenografts. Recombinant clones from the library were screened directly from bacterial colonies by PCR and the nucleic acid sequences of the clones established...
December 27, 1995: Transplantation
G D Wu, D V Cramer, F A Chapman, R Oriol, L Makowka
The rejection of cardiac xenografts in the hamster-to-rat combination is characterized by the production of IgM antibodies that result in the rapid loss of the graft. We have recently produced rat monoclonal antibodies (mAb) to hamster heart xenografts in an attempt to develop reagents for use in identifying the target antigens for this reaction and to study the nature of the genetic control of the humoral response. The monoclonals were created by the fusion of myeloma cells with splenic lymphocytes from LEW rat recipients of hamster cardiac xenografts...
December 27, 1995: Transplantation
G Hein, G Eidner, T Eidner, I Marzoll, M Klinner
The outcome of RF-activity (measured by hemagglutination in the modification of Podliachouk-Harboe) was investigated in 95 patients with RA. In 52 of these patients the radiological progression (modification of Larsen index for hands and feet) in correlation to the outcome of RF was assessed. The results can be summarized in the following way: 1. Elderly RA patients show a significant elevation of RF titer. 2. There is a statistically insignificant correlation between age of RA manifestation and RF level. 3...
November 1993: Zeitschrift Für Rheumatologie
D V Cramer, G D Wu, R Oriol, L Makowka
No abstract text is available yet for this article.
April 1995: Transplantation Proceedings
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