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Cancer AND comorbidity

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https://www.readbyqxmd.com/read/29678980/health-related-quality-of-life-in-asian-patients-with-breast-cancer-a-systematic-review
#1
Peh Joo Ho, Sofie A M Gernaat, Mikael Hartman, Helena M Verkooijen
OBJECTIVE: To summarise the evidence on determinants of health-related quality of life (HRQL) in Asian patients with breast cancer. DESIGN: Systematic review conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations and registered with PROSPERO (CRD42015032468). METHODS: According to the PRISMA guidelines, databases of MEDLINE (PubMed), Embase and PsycINFO were systematically searched using the following terms and synonyms: breast cancer, quality of life and Asia...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29675660/rates-of-prevalent-colorectal-cancer-occurrence-in-persons-75-years-of-age-and-older-a-population-based-national-study
#2
Vijit Chouhan, Emad Mansoor, Sravanthi Parasa, Gregory S Cooper
BACKGROUND/AIMS: There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, population-based database as this may impact screening guidelines in this population. METHODS: Utilizing a commercial database (Explorys Inc, Cleveland, OH), we identified a cohort of patients with a first-ever diagnosis of CRC between 2012 and 2017 based on the Systematized Nomenclature of Medicine-Clinical Terms...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#3
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29675061/comorbidities-with-non-small-cell-lung-cancer-is-there-an-interdisciplinary-consensus-needed-to-qualify-patients-for-surgical-treatment
#4
Marta Lembicz, Piotr Gabryel, Beata Brajer-Luftmann, Wojciech Dyszkiewicz, Halina Batura-Gabryel
INTRODUCTION: Radical surgical treatment is the preferred action for patients with early-stage non-small cell lung cancer (NSCLC). Qualification for surgical treatment should consider a risk associated with the effect of comorbidities on the general condition of the patient. The aim of this article was an attempt to identify the risk factors for postoperative complications in patients treated for NSCLC, with a special focus on the coexisting diseases. METHODS: A total of 400 patients with NSCLC were included in this retrospective study...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29674441/promoting-accrual-of-older-patients-with-cancer-to-clinical-trials-an-alliance-for-clinical-trials-in-oncology-member-survey-a171602
#5
Rachel A Freedman, Travis J Dockter, Jacqueline M Lafky, Arti Hurria, Hyman J Muss, Harvey J Cohen, Aminah Jatoi, M Margaret Kemeny, Kathryn J Ruddy
BACKGROUND: There are multiple known individual- and practice-level barriers to enrollment of older patients with cancer to clinical trials, but little is known about how the clinical research workforce feels about potential higher-level strategy changes aimed to promote increased enrollment of older patients. SUBJECTS, MATERIALS, AND METHODS: We invited all 11,351 Alliance for Clinical Trials in Oncology ("Alliance") members to participate in an anonymous, web-based survey to examine awareness of current accrual patterns for older patients to clinical trials, to ascertain consensus on how to tackle enrollment challenges, and to provide the impetus for high-level changes to improve clinical trial accrual of older patients with cancer...
April 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29674000/angiotensin-ii-promotes-pulmonary-metastasis-of-melanoma-through-the-activation-of-adhesion-molecules-in-vascular-endothelial-cells
#6
Shin Ishikane, Hiroshi Hosoda, Takashi Nojiri, Takeshi Tokudome, Tetsuya Mizutani, Koichi Miura, Yoshiharu Akitake, Toru Kimura, Yoshitaka Imamichi, Shinya Kawabe, Yumiko Toyohira, Nobuyuki Yanagihara, Fumi Takahashi-Yanaga, Mikiya Miyazato, Kaoru Miyamoto, Kenji Kangawa
Hypertension is considered as one of the cancer progressive factors, and often found comorbidity in cancer patients. Renin-angiotensin system (RAS) plays an important role in the regulation of blood pressure, and angiotensin II (Ang II) is well known pressor peptide associated with RAS. Ang II has been reported to accelerate progression and metastasis of cancer cells. However, its precise mechanisms have not been fully understood. In this study, we sought to elucidate the mechanisms by which Ang II exacerbates hematogenous metastasis in mouse melanoma cells, focusing the adhesion pathway in vascular endothelial cells...
April 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29673806/the-challenges-of-bacillus-of-calmette-guerin-bcg-therapy-for-high-risk-non-muscle-invasive-bladder-cancer-treatment-in-older-patients
#7
Marco Racioppi, Luca Di Gianfrancesco, Mauro Ragonese, Giuseppe Palermo, Emilio Sacco, PierFrancesco Bassi
OBJECTIVES: To evaluate the efficacy and safety of a tailored endovesical immunotherapy protocol with biweekly BCG for elderly Patients with high risk non muscle invasive bladder cancer (HG-NMIBC). MATERIALS AND METHODS: We retrospectively evaluated data from 200 patients older than 80 years newly diagnosed with HG-NMIBC: 100 (group 1) with multiple comorbidities (WHO PS 2-3, ASA score ≥3, Charlson Comorbidity index ≥3, GFR<60 mL/min) were treated with BCG induction course administered biweekly; 100 (group 2) with statistically significant better conditions were treated with standard weekly BCG therapy...
April 16, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29672754/comorbidity-clusters-in-people-with-gout-an-observational-cohort-study-with-linked-medical-record-review
#8
Megan Bevis, Milisa Blagojevic-Bucknall, Christian Mallen, Samantha Hider, Edward Roddy
Objective: To investigate how comorbid conditions cluster in patients with gout in a UK primary care population. Methods: A cross-sectional study was performed using baseline data from a primary-care-based prospective observational cohort of people aged ⩾18 years with gout. Participants with gout were identified through primary care medical records. Factor analysis was performed to obtain distinct clusters of comorbidity variables including obesity, hypertension, diabetes mellitus, hyperlipidaemia, coronary heart disease, heart failure, chronic kidney disease (CKD) and cancer...
April 17, 2018: Rheumatology
https://www.readbyqxmd.com/read/29672628/derivation-and-internal-validation-of-a-mortality-risk-index-for-aged-people-living-with-hiv-the-dat-aids-score
#9
Maxime Hentzien, Cyrille Delpierre, Pascal Pugliese, Clotilde Allavena, Christine Jacomet, Marc-Antoine Valantin, André Cabié, Lise Cuzin, David Rey, Firouzé Bani-Sadr, Moustapha Dramé
OBJECTIVE: The objective was to develop a multivariable prognostic index for overall mortality over a five-year span integrating classical HIV biomarkers and comorbidities in people living with HIV (PLHIV) aged 60 or older. DESIGN: Prospective multicenter cohort study from the French Dat'AIDS cohort. METHODS: All HIV-1 infected patients aged 60 years or older on 1st January 2008 were included. Sociodemographic data, CD4 cell count, CD4 nadir, HIV viral load, history of comorbidities, hepatitis co-infections and laboratory parameters at baseline were considered as potential prognostic variables...
2018: PloS One
https://www.readbyqxmd.com/read/29672399/minimally-invasive-lobectomy-is-associated-with-lower-noncancer-specific-mortality-in-elderly-patients-a-propensity-score-matched-competing-risks-analysis
#10
Boris Hristov, Takashi Eguchi, Sarina Bains, Joe Dycoco, Kay See Tan, James M Isbell, Bernard J Park, David R Jones, Prasad S Adusumilli
OBJECTIVE: To investigate cancer- and noncancer-specific mortality following lobectomy by minimally invasive surgery (MIS) versus open thoracotomy in elderly patients with nonsmall cell lung cancer (NSCLC). BACKGROUND: Two-thirds of patients with NSCLC are ≥65 years of age. As age increases, the risk of competing events, such as noncancer death, also increases. METHODS: Elderly patients (≥65 yrs of age) who have undergone curative-intent lobectomy for stage I-III NSCLC without induction therapy (2002-2013) were included (n=1,303)...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29672125/submassive-pulmonary-embolism
#11
Parth M Rali, Gerard J Criner
Pulmonary Embolism (PE) presents a spectrum of hemodynamic consequences ranging from being asymptomatic to a life-threatening medical emergency. Management of sub massive and massive PE often involves clinicians from multiple specialties that can potentially delay the development of a unified treatment plan. Additionally, patients with submassive PE can deteriorate after their presentation and require escalation of care. Underlying comorbidities like chronic obstructive pulmonary disease (COPD), cancer, congestive heart failure and interstitial lung disease can impact the patient's hemodynamic ability to tolerate submassive PE...
April 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29671955/smoking-drinking-and-depression-comorbidity-in-head-and-neck-cancer-patients-undergoing-radiotherapy
#12
Kristen McCarter, Amanda L Baker, Benjamin Britton, Luke Wolfenden, Chris Wratten, Judith Bauer, Sean A Halpin, Gregory Carter, Alison K Beck, Lucy Leigh, Christopher Oldmeadow
We aimed to determine the prevalence and co-occurrence of tobacco smoking, alcohol consumption, and depressive symptoms among a sample of head and neck cancer (HNC) patients undergoing radiotherapy. A total of 307 HNC patients participated in a multi-site stepped-wedge randomized controlled trial (RCT) evaluating the effectiveness of a dietitian-delivered health behavior intervention in patients with HNC undergoing radiotherapy. During week one of radiotherapy patients completed measures of smoking, alcohol consumption, and level of depression...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29671552/cervical-cancer-evaluation-and-management
#13
Jennifer Wipperman, Tara Neil, Tracy Williams
Human papillomavirus infection is the precursor for the development of cervical cancer and is detectable in 99.7% of squamous cell carcinoma and adenocarcinoma cases. Early detection of precancerous lesions with Papanicolaou testing remains the primary mechanism for cancer prevention. Once cervical cancer is diagnosed, treatment may involve surgery, radiation therapy, chemotherapy, or a combination. The choice of therapy depends on the stage of disease, lymph node involvement, patient comorbidities, and risk factors for recurrence...
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29669572/one-year-and-three-year-mortality-prediction-in-adult-major-blunt-trauma-survivors-a-national-retrospective-cohort-analysis
#14
Ting Hway Wong, Nivedita Vikas Nadkarni, Hai V Nguyen, Gek Hsiang Lim, David Bruce Matchar, Dennis Chuen Chai Seow, Nicolas K K King, Marcus Eng Hock Ong
BACKGROUND: Survivors of trauma are at increased risk of dying after discharge. Studies have found that age, head injury, injury severity, falls and co-morbidities predict long-term mortality. The objective of our study was to build a nomogram predictor of 1-year and 3-year mortality for major blunt trauma adult survivors of the index hospitalization. METHODS: Using data from the Singapore National Trauma Registry, 2011-2013, we analyzed adults aged 18 and over, admitted after blunt injury, with an injury severity score (ISS) of 12 or more, who survived the index hospitalization, linked to death registry data...
April 18, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29669187/patient-views-and-correlates-of-radiotherapy-omission-in-a-population-based-sample-of-older-women-with-favorable-prognosis-breast-cancer
#15
Dean A Shumway, Kent A Griffith, Sarah T Hawley, Lauren P Wallner, Kevin C Ward, Ann S Hamilton, Monica Morrow, Steven J Katz, Reshma Jagsi
BACKGROUND: The omission of radiotherapy (RT) after lumpectomy is a reasonable option for many older women with favorable-prognosis breast cancer. In the current study, we sought to evaluate patient perspectives regarding decision making about RT. METHODS: Women aged 65 to 79 years with AJCC 7th edition stage I and II breast cancer who were reported to the Georgia and Los Angeles County Surveillance, Epidemiology, and End Results registries were surveyed (response rate, 70%) regarding RT decisions, the rationale for omitting RT, decision-making values, and understanding of disease recurrence risk...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29668600/chilean-gastric-cancer-task-force-a-study-protocol-to-obtain-a-clinical-and-molecular-classification-of-a-cohort-of-gastric-cancer-patients
#16
Gareth I Owen, Mauricio P Pinto, Ignacio N Retamal, María F Fernádez, Betzabe Cisternas, Sebastian Mondaca, Cesar Sanchez, Hector Galindo, Bruno Nervi, Carolina Ibañez, Francisco Acevedo, Jorge Madrid, José Peña, Maria Loreto Bravo, Maria Jose Maturana, Miguel Cordova-Delgado, Diego Romero, Nathaly de la Jara, Javiera Torres, Maria Rodriguez-Fernandez, Manuel Espinoza, Carlos Balmaceda, Matías Freire, Valentina Gárate-Calderón, Fernando Crovari, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas, Ariel Zwenger, Ricardo Armisen, Alejandro H Corvalan, Marcelo Garrido
Gastric cancer (GC) is the world's second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to "one size fits all" therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668209/the-well-being-of-long-term-cancer-survivors
#17
Jeffrey Sullivan, Julia Thornton Snider, Emma van Eijndhoven, Tony Okoro, Katharine Batt, Thomas DeLeire
OBJECTIVES: To compare the well-being of long-term cancer survivors with that of US residents of similar age and demographic characteristics, patients recently diagnosed with cancer, and individuals with chronic illness. STUDY DESIGN: Retrospective observational study. METHODS: Using the Health and Retirement Study, a survey of US residents older than 50 years, we defined 4 cohorts: long-term cancer survivors (>4 years post diagnosis), individuals recently diagnosed with cancer (≤4 years post diagnosis), individuals with chronic illness, and US residents older than 50 years ("nationally representative cohort")...
April 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29666603/long-term-factors-associated-with-falls-and-fractures-poststroke
#18
Emma J Foster, Raphae S Barlas, Joao H Bettencourt-Silva, Allan B Clark, Anthony K Metcalf, Kristian M Bowles, John F Potter, Phyo K Myint
Background: Risk factors for poststroke falls and fractures remain poorly understood. This study aimed to evaluate which factors increased risk of these events after stroke. Methods: Data from 7,267 hospitalized stroke patients were acquired from the Norfolk and Norwich University Hospital Stroke Register from 2003-2015. The impacts of multiple patient level and stroke characteristics and comorbidities on post-discharge falls and fractures were assessed. Univariate and multivariable models were constructed, adjusting for multiple confounders, using binary logistic regression for short-term analysis (up to 1-year post-discharge) and Cox-proportional hazard models for longer term analysis (1-3, 3-5, and 0-10 years follow-up)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29665118/locoregionally-advanced-oral-cavity-cancer-a-propensity-score-matched-analysis-on-overall-survival-with-emphasis-on-the-impact-of-adjuvant-radiotherapy
#19
Jacob Y Shin, Ja Kyoung Yoon, Aaron K Shin, Aidnag Z Diaz
BACKGROUND: The purpose of this study was to determine the impact of adjuvant radiotherapy (RT) in locoregionally advanced oral cavity cancer. METHODS: Data were extracted from the National Cancer Data Base, of which overall survival (OS) is the only outcome variable available. The chi-square test and Cox regression models were used. RESULTS: A total of 6654 patients were identified. The utilization of adjuvant RT has increased over time. A propensity matched cohort included 3946 patients, exactly one-half of whom received adjuvant RT...
April 17, 2018: Head & Neck
https://www.readbyqxmd.com/read/29662629/pre-diagnostic-biomarkers-of-metabolic-dysregulation-and-cancer-mortality
#20
Tomi Akinyemiju, Justin Xavier Moore, Suzanne E Judd, Maria Pisu, Michael Goodman, Virginia J Howard, Leann Long, Monika Safford, Susan C Gilchrist, Mary Cushman
INTRODUCTION: The obesogenic milieu is a pro-tumorigenic environment that promotes tumor initiation, angiogenesis and metastasis. In this prospective cohort, we examined the association between pre-diagnostic metabolic biomarkers, plasma adiponectin, resistin, leptin and lipoprotein (a), and the risk of cancer mortality. METHODS: Prospective data was obtained from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort of Blacks and Whites followed from 2003 through 2012 for cancer mortality...
March 23, 2018: Oncotarget
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