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Cancer AND comorbidity

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https://www.readbyqxmd.com/read/29455958/esophagectomy-versus-endoscopic-resection-for-patients-with-early-stage-esophageal-adenocarcinoma-a-national-cancer-database-propensity-matched-study
#1
Katy A Marino, Jennifer L Sullivan, Benny Weksler
OBJECTIVES: Endoscopic resection has been rapidly adopted in the treatment of early-stage esophageal tumors. We compared the outcomes after esophagectomy or endoscopic resection for stage T1a adenocarcinoma. METHODS: We queried the National Cancer Database for patients with T1a esophageal adenocarcinoma who underwent esophagectomy or endoscopic resection and generated a balanced cohort with 735 matched pairs using propensity-score matching. We then performed a multivariable Cox regression analysis on the matched and unmatched cohorts...
January 31, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29453868/coexistent-solid-malignancies-in-pemphigus-a-population-based-study
#2
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
Importance: The association of pemphigus vulgaris and pemphigus foliaceus with comorbid malignancies is yet to be firmly established. Objective: To estimate the association between pemphigus and a wide range of nonhematologic malignancies using one of the largest cohorts of patients with pemphigus to date. Design, Setting, and Participants: For this cross-sectional study, we used the computerized database of Clalit Health Services, the largest public health care provider organization in Israel insuring 4...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29453297/what-factors-mediate-the-inter-relationship-between-frailty-and-pain-in-cognitively-and-functionally-sound-older-adults-a-prospective-longitudinal-ageing-cohort-study-in-taiwan
#3
Jing-Hui Chiou, Li-Kuo Liu, Wei-Ju Lee, Li-Ning Peng, Liang-Kung Chen
OBJECTIVES: The main aim was to investigate the complex inter-relationship between frailty and pain, and the mediating roles of cognitive function, morbidity and mood in this nexus. DESIGN: A cross-sectional analysis. SETTING: A prospective community-dwelling population-based cohort. PARTICIPANTS: 1682 adults age ≥50 years without evident cognitive or functional impairment, or history of cancer. PRIMARY AND SECONDARY OUTCOME MEASURES: The mediating effect of depression, cognitive function and comorbidity on the nexus between pain and frailty among older and middle-aged adults...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29452979/3-piece-inflatable-penile-prosthesis-placement-following-radical-cystoprostatectomy-and-urinary-diversion-technique-and-outcomes
#4
Jeffrey Loh-Doyle, Mukul B Patil, Hari Sawkar, Kevin Wayne, Stuart D Boyd
BACKGROUND: After radical cystoprostatectomy (RC), postoperative erectile dysfunction (ED) is a common consequence with multiple contributing etiologies. The inflatable penile prosthesis (IPP) offers patients a definitive treatment option when ED is refractory to medical therapies. Because of the hostile postoperative anatomy of these patients, a careful surgical approach is necessary for successful outcomes and to avoid adjacent organ injury. To date, there is no series describing the outcomes of 3-piece IPP placement in patients with urinary diversions...
February 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29452805/perioperative-cardiopulmonary-exercise-testing-cpet-consensus-clinical-guidelines-on-indications-organization-conduct-and-physiological-interpretation
#5
D Z H Levett, S Jack, M Swart, J Carlisle, J Wilson, C Snowden, M Riley, G Danjoux, S A Ward, P Older, M P W Grocott
The use of perioperative cardiopulmonary exercise testing (CPET) to evaluate the risk of adverse perioperative events and inform the perioperative management of patients undergoing surgery has increased over the last decade. CPET provides an objective assessment of exercise capacity preoperatively and identifies the causes of exercise limitation. This information may be used to assist clinicians and patients in decisions about the most appropriate surgical and non-surgical management during the perioperative period...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29452704/substance-use-disorder-among-current-cancer-patients-rates-and-correlates-nationally-in-the-department-of-veterans-affairs
#6
Pochu Ho, Robert Rosenheck
BACKGROUND: Substance use disorders (SUDs) are known to cause or complicate treatment of many types of cancers. OBJECTIVES: We sought to systematically assess rates of current SUDs among patients currently in treatment for cancer. METHODS: The National Veteran Health Administration administrative data from fiscal year 2012 were used to compare veterans with both cancer and comorbid SUDs to veterans with cancer but no SUDs and those with a SUD but no cancer...
January 10, 2018: Psychosomatics
https://www.readbyqxmd.com/read/29451944/total-hip-arthroplasty-in-patients-with-avascular-necrosis-after-hematopoietic-stem-cell-transplantation
#7
Anita Vijapura, Harlan B Levine, Michele Donato, Mark A Hartzband, Melissa Baker, Gregg R Klein
The immunosuppressive regimens required for hematopoietic stem cell transplantation predispose recipients to complications, including avascular necrosis. Cancer-related comorbidities, immunosuppression, and poor bone quality theoretically increase the risk for perioperative medical complications, infection, and implant-related complications in total joint arthroplasty. This study reviewed 20 primary total hip arthroplasties for avascular necrosis in 14 patients. Outcomes were assessed at routine clinical visits and Harris hip scores were calculated...
February 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29451695/decreased-early-mortality-associated-with-the-treatment-of-acute-myeloid-leukemia-at-national-cancer-institute-designated-cancer-centers-in-california
#8
Gwendolyn Ho, Ted Wun, Lori Muffly, Qian Li, Ann Brunson, Aaron S Rosenberg, Brian A Jonas, Theresa H M Keegan
BACKGROUND: To the authors' knowledge, few population-based studies to date have evaluated the association between location of care, complications with induction therapy, and early mortality in patients with acute myeloid leukemia (AML). METHODS: Using linked data from the California Cancer Registry and Patient Discharge Dataset (1999-2014), the authors identified adult (aged ≥18 years) patients with AML who received inpatient treatment within 30 days of diagnosis...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29451672/predictors-of-persistent-prescription-opioid-analgesic-use-among-people-without-cancer-in-australia
#9
Samanta Lalic, Natasa Gisev, J Simon Bell, Maarit Jaana Korhonen, Jenni Ilomäki
AIMS: To identify patterns of opioid analgesic use and determine predictors of persistent opioid use among people without cancer. METHODS: A population-based cohort study of Australians initiating prescription opioids from July 2013 to December 2015 was conducted using data from a random 10% sample of people who accessed medicines through Australia's Pharmaceutical Benefits Scheme. A 12-month look-back period was used to define opioid initiation, exclude people with cancer, and determine comorbidities...
February 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29451070/confounders-other-than-comorbidity-explain-survival-differences-in-danish-and-swedish-ovarian-cancer-patients-a-comparative-cohort-study
#10
Mette Calundann Noer, Pia Leandersson, Torbjørn Paulsen, Susanne Rosthøj, Sofie Leisby Antonsen, Christer Borgfeldt, Claus Høgdall
OBJECTIVE: Danish ovarian cancer (OC) patients have previously been found to have worse prognosis than Swedish patients, and comorbidity has been suggested as a possible explanation for this survival difference. We aimed to investigate the prognostic impact of comorbidity in surgically treated OC patients in Denmark and Sweden. METHODS: This comparative cohort study was based on data from 3118 surgically treated OC patients diagnosed in 2012-2015. The Swedish subcohort (n = 1472) was identified through the Swedish National Quality Register of Gynecological Surgery, whereas the Danish subcohort (n = 1646) originated from the Danish Gynecological Cancer Database...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29450753/use-of-breast-imaging-after-treatment-for-locoregional-breast-cancer-aft-01
#11
Taiwo Adesoye, Jessica R Schumacher, Heather B Neuman, Stephen Edge, Daniel McKellar, David P Winchester, Amanda B Francescatti, Caprice C Greenberg
BACKGROUND: Annual mammography is recommended after breast cancer treatment. However, studies suggest its under-utilization for Medicare patients. Utilization in the broader population is unknown, as is the role of breast magnetic resonance imaging (MRI). Understanding factors associated with imaging use is critical to improvement of adherence to recommendations. METHODS: A random sample of 9835 eligible patients receiving surgery for stages 2 and 3 breast cancer from 2006 to 2007 was selected from the National Cancer Database for primary data collection...
February 15, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29445590/enhanced-recovery-after-surgery-eras-and-fast-track-in-video-assisted-thoracic-surgery-vats-lobectomy-preoperative-optimisation-and-care-plans
#12
REVIEW
Antonio D'Andrilli, Erino A Rendina
Main specific interventions for preoperative clinical optimisation of patients undergoing lung cancer surgery include assessment and treatment of comorbidities, minimizing preoperative hospitalization, minimizing preoperative fasting, and optimisation of antibiotic and thrombo-embolic prophylaxis. Preoperative patient optimisation is considered a crucial part of enhanced recovery after thoracic surgery pathways. Potentially, advantages of this fast-track management could be even higher when considering video-assisted thoracic surgery (VATS) major lung resection, because reduced trauma related to minimally invasive techniques is one of the main factors improving postoperative outcome...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29445452/exploiting-immune-cell-metabolic-machinery-for-functional-hiv-cure-and-the-prevention-of-inflammaging
#13
REVIEW
Clovis S Palmer, Riya Palchaudhuri, Hassan Albargy, Mohamed Abdel-Mohsen, Suzanne M Crowe
An emerging paradigm in immunology suggests that metabolic reprogramming and immune cell activation and functions are intricately linked. Viral infections, such as HIV infection, as well as cancer force immune cells to undergo major metabolic challenges. Cells must divert energy resources in order to mount an effective immune response. However, the fact that immune cells adopt specific metabolic programs to provide host defense against intracellular pathogens and how this metabolic shift impacts immune cell functions and the natural course of diseases have only recently been appreciated...
2018: F1000Research
https://www.readbyqxmd.com/read/29445028/evaluation-of-treatment-patterns-and-survival-outcomes-in-elderly-pancreatic-cancer-patients-a-surveillance-epidemiology-and-end-results-medicare-analysis
#14
Walid L Shaib, Jeb S Jones, Michael Goodman, Juan M Sarmiento, Shishir K Maithel, Kenneth Cardona, Sujata Kane, Christina Wu, Olatunji B Alese, Bassel F El-Rayes
BACKGROUND: Management of pancreatic cancer (PC) in elderly patients is unknown; clinical trials exclude patients with comorbidities and those of extreme age. This study evaluated treatment patterns and survival outcomes in elderly PC patients using linked Surveillance, Epidemiology, and End Results (SEER) and Medicare data. MATERIALS AND METHODS: Histology codes 8140, 8500, 8010, 8560, 8490, 8000, 8260, 8255, 8261, 8263, 8020, 8050, 8141, 8144, 8210, 8211, or 8262 in Medicare Parts A and B were identified...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29443930/imbalanced-nutrient-intake-in-cancer-survivors-from-the-examination-from-the-nationwide-health-examination-center-based-cohort
#15
Boyoung Park, Jinhee Lee, Jeongseon Kim
This study was conducted to examine the nutrient intake status of cancer survivors. A total of 5224 cancer survivors, 19,926 non-cancer individuals without comorbidities (non-cancer I), and 20,622 non-cancer individuals with comorbidities, matched by age, gender, and recruitment center location were included in the analysis. Generally, the proportion of total energy from carbohydrates was higher and the proportion from fat was lower in cancer survivors. The odds ratios (ORs) for total energy (OR = 0.92, 95% confidence interval (CI) = 0...
February 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29443648/readmission-patterns-after-gi-cancer-hospitalizations-the-medical-versus-surgical-patient
#16
Joanna-Grace M Manzano, Ming Yang, Hui Zhao, Linda S Elting, Marina C George, Ruili Luo, Maria E Suarez-Almazor
PURPOSE: Readmission within 30 days has been used as a metric for quality of care received at hospitals for certain diagnoses. In the era of accountability, value-based care, and increasing cancer costs, policymakers are looking into cancer readmissions as well. It is important to describe the readmission profile of patients with cancer in the most clinically relevant approach to inform policy and health care delivery that can positively impact patient outcomes. PATIENTS AND METHODS: We conducted a retrospective cohort study using linked Texas Cancer Registry and Medicare claims data...
February 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29442282/complications-within-90-days-after-radical-cystectomy-for-bladder-cancer-results-of-a-multicenter-prospective-study-in-japan
#17
Megumi Hirobe, Toshiaki Tanaka, Tetsuya Shindo, Koji Ichihara, Hiroshi Hotta, Atsushi Takahashi, Ryuichi Kato, Masahiro Yanase, Masanori Matsukawa, Naoki Itoh, Yasuharu Kunishima, Keisuke Taguchi, Hiroki Horita, Naoya Masumori
PURPOSE: We prospectively evaluated the 90-day postoperative mortality and morbidity of open radical cystectomy by using a standardized reporting methodology. Additionally, we assessed the preoperative characteristics to determine risk factors for major complications. METHODS: This multicenter prospective study included 185 consecutive patients undergoing open radical cystectomy from October 2010 through March 2014. Postoperative complications within 90 days were recorded and graded according to the modified Clavien-Dindo classification...
February 13, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29442216/psychiatric-comorbidities-among-patients-undergoing-liver-transplantation-in-south-korea-a-nationwide-population-based-study
#18
Jaesung Heo, O Kyu Noh, Young-Taek Oh, Mison Chun, Logyoung Kim
OBJECTIVES: The aim of this study was to analyze the prevalence of mental disorders in patients undergoing liver transplantation (LT) based on claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea. METHODS: We confirmed mental disorders in a nationwide cohort of 3758 patients receiving LT between January 2010 and December 2014. We categorized the prevalence of mental disorders based on patient age at the time of LT. RESULTS: A total of 288 patients for LT were diagnosed with a mental disorder 1 year before their cancer diagnosis...
February 13, 2018: Hepatology International
https://www.readbyqxmd.com/read/29439082/association-of-common-comorbidities-with-osteonecrosis-a-nationwide-population-based-case-control-study-in-denmark
#19
Alina Dima, Alma Becic Pedersen, Lars Pedersen, Cristian Baicus, Reimar Wernich Thomsen
OBJECTIVE: To examine recent time trends in the incidence of osteonecrosis (ON) in Denmark and to investigate different common comorbidities association with ON in a population-based setting. METHODS: Using Danish medical databases, we included all patients with a first-time hospital diagnosis of ON during 1995-2012. Each ON case was matched with 10 randomly selected population control subjects from general population. For all participants, we obtained a complete hospital history of comorbidities included in the CharlsonComorbidity Index 5 years preceding the inclusion date...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29435901/factors-associated-with-emergency-department-utilization-and-admission-in-patients-with-colorectal-cancer
#20
Tiffany K Weidner, John T Kidwell, David A Etzioni, Lindsey R Sangaralingham, Holly K Van Houten, Dennis Asante, Molly Moore Jeffery, Nilay Shah, Nabil Wasif
PURPOSE: We assessed emergency department (ED) utilization in patients with colorectal cancer to identify factors associated with ED visits and subsequent admission, as well as identify a high-risk subset of patients that could be targeted to reduce ED visits. METHODS: Data from Optum Labs Data Warehouse, a national administrative claims database, was retrospectively analyzed to identify patients with colorectal cancer from 2008 to 2014. Multivariable logistic regression was used to identify factors associated with ED visits and ED "super-users" (3+ visits)...
February 12, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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