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Lucas A de Azeredo, Diego L Rovaris, Nina R Mota, Evelise R Polina, Francine Z Marques, Verônica Contini, Eduardo S Vitola, Paulo Belmonte-de-Abreu, Luis A Rohde, Eugenio H Grevet, Claiton H D Bau
No abstract text is available yet for this article.
October 17, 2016: European Archives of Psychiatry and Clinical Neuroscience
Kaijing Ding, Jianzhong Yang, Gavin P Reynolds, Bing Chen, Jingru Shao, Ruixiang Liu, Qiujin Qian, Hua Liu, Runxu Yang, Jianfan Wen, Chuanyuan Kang
OBJECTIVES: To examine the association of the DNA methylation of DAT1 and DRD4 gene with methylphenidate (MPH) response in attention deficit hyperactivity disorder (ADHD). METHODS: One hundred and eleven DSM-IV defined ADHD Chinese Han children were recruited. Inattention, hyperactivity-impulsivity and oppositional symptoms were evaluated by the Swanson, Nolan and Pelham-IV-parent rating scale (SNAP-IV-P) at baseline and 6 weeks after MPH treatment. DNA methylation of CpG sites in the promoter sequences of DAT1 and DRD4 was examined for association with treatment response...
September 27, 2016: World Journal of Biological Psychiatry
Lizanne J S Schweren, Catharina A Hartman, Dirk J Heslenfeld, Annabeth P Groenman, Barbara Franke, Jaap Oosterlaan, Jan K Buitelaar, Pieter J Hoekstra
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) has been associated with dopaminergic imbalance and subtle volume decreases in the brain. Stimulants acutely enhance dopaminergic neurotransmission. Long-term effects of prolonged manipulation of the dopaminergic system on brain structure remain poorly understood; they could be beneficial or unfavorable and could be moderated by common genetic variants and/or age. METHOD: In a large observational ADHD cohort study (N = 316), the effects of cumulative stimulant treatment, genotype (for DAT1 haplotype and DRD4 variants), and treatment-by-genotype interactions on striatal, frontal, and hippocampal volumes and their interactions with age were evaluated...
October 2016: Journal of the American Academy of Child and Adolescent Psychiatry
Rabia R Chhangur, Joyce Weeland, Geertjan Overbeek, Walter Matthys, Bram Orobio de Castro, Danielle van der Giessen, Jay Belsky
This study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families with 4- to 8-year-old children (55.7% boys) showing moderate to high levels of problem behavior. IY proved to be most effective in decreasing parent-reported (but not observed) externalizing behavior in boys (but not girls) carrying more rather than fewer dopaminergic plasticity alleles; this Gene × Intervention effect was most pronounced in the case of boys whose parents' manifested the most positive change in parenting in response to the intervention...
September 15, 2016: Child Development
Diana R Samek, Jennifer Bailey, Karl G Hill, Sylia Wilson, Susanne Lee, Margaret A Keyes, Marina Epstein, Andrew Smolen, Michael Miller, Ken C Winters, J David Hawkins, Richard F Catalano, William G Iacono, Matt McGue
This study presents results from a collaboration across five longitudinal studies seeking to test and replicate models of gene-environment interplay in the development of substance use and externalizing disorders (SUDs, EXT). We describe an overview of our conceptual models, plan for gene-environment interplay analyses, and present main effects results evaluating six candidate genes potentially relevant to SUDs and EXT (MAOA, 5-HTTLPR, COMT, DRD2, DAT1, and DRD4). All samples included rich longitudinal and phenotypic measurements from childhood/adolescence (ages 5-13) through early adulthood (ages 25-33); sample sizes ranged from 3487 in the test sample, to ~600-1000 in the replication samples...
September 2016: Behavior Genetics
Ching-Jung Yu, Jung-Chieh Du, Hsien-Chih Chiou, Chun-Cheng Feng, Ming-Yi Chung, Winnie Yang, Ying-Sheue Chen, Ling-Chu Chien, Betau Hwang, Mei-Lien Chen
Attention deficit/hyperactivity disorder (ADHD) is one of the most common childhood neurobehavioral conditions. Evidence of the negative effects of sugar-sweetened beverages (SSBs) on mental health has not been convincing, although a few studies have found an association between high SSB levels and attention problems in children. This study aimed to test the hypothesis that SSB consumption is associated with ADHD among children. Doctor-diagnosed ADHD cases (n = 173) and non-ADHD controls (n = 159) between age 4 to 15 were recruited...
2016: International Journal of Environmental Research and Public Health
Anna Junkiert-Czarnecka, Olga Haus
Intelligence as an ability to reason, think abstractly and adapt effectively to the environment is a subject of research in the field of psychology, neurobiology, and in the last twenty years genetics as well. Genetical testing of twins carried out from XX century indicated heritebility of intelligence, therefore confirmed an influence of genetic factor on cognitive processes. Studies on genetic background of intelligence focus on dopaminergic (DRD2, DRD4, COMT, SLC6A3, DAT1, CCKAR) and adrenergic system (ADRB2, CHRM2) genes as well as, neutrofins (BDNF) and oxidative stress genes (LTF, PRNP)...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
Glaucia C Akutagava-Martins, Angelica Salatino-Oliveira, Christian Kieling, Julia P Genro, Guilherme V Polanczyk, Luciana Anselmi, Ana M B Menezes, Helen Gonçalves, Fernando C Wehrmeister, Fernando C Barros, Sidia M Callegari-Jacques, Luis A Rohde, Mara H Hutz
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptoms are dimensionally distributed in the population. This study aimed to assess the role of the catechol-O-methyltransferase (COMT) and of the dopamine transporter (DAT1) genes on ADHD symptoms in the general population. METHODS: We investigated 4101 individuals from the 1993 Pelotas Birth Cohort Study using the parent version of the Strengths and Difficulties Questionnaire (SDQ) at ages 11 and 15 years...
June 21, 2016: Journal of Psychiatry & Neuroscience: JPN
Steven De Laet, Hilde Colpin, Karla Van Leeuwen, Wim Van den Noortgate, Stephan Claes, Annelies Janssens, Luc Goossens, Karine Verschueren
This study examined whether the dopamine transporter DAT1 and the dopamine receptor DRD4 genes moderate the effect of student-reported teacher-student relationship affiliation or dissatisfaction on parent-reported adolescent rule-breaking behavior and behavioral engagement. The sample included 1053 adolescents (51% boys, Mage=13.79) from grades 7 to 9. Regression analyses were conducted using Mplus while controlling for multiple testing and nested data. Adolescents who experienced stronger affiliation with their teachers were more engaged in school, whereas greater dissatisfaction predicted more rule-breaking behavior...
June 2016: Journal of School Psychology
Jennifer S Richards, Alejandro Arias Vásquez, Barbara Franke, Pieter J Hoekstra, Dirk J Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Jan K Buitelaar, Catharina A Hartman
Smaller total brain and subcortical volumes have been linked to psychopathology including attention-deficit/hyperactivity disorder (ADHD). Identifying mechanisms underlying these alterations, therefore, is of great importance. We investigated the role of gene-environment interactions (GxE) in interindividual variability of total gray matter (GM), caudate, and putamen volumes. Brain volumes were derived from structural magnetic resonance imaging scans in participants with (N = 312) and without ADHD (N = 437) from N = 402 families (age M = 17...
2016: PloS One
Jennifer S Richards, Alejandro Arias Vásquez, Daan van Rooij, Dennis van der Meer, Barbara Franke, Pieter J Hoekstra, Dirk J Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Catharina A Hartman, Jan K Buitelaar
OBJECTIVES: Impaired inhibitory control is a key feature of attention-deficit/hyperactivity disorder (ADHD). We investigated gene-environment interaction (GxE) as a possible contributing factor to response inhibition variation in context of the differential susceptibility theory. This states individuals carrying plasticity gene variants will be more disadvantaged in negative, but more advantaged in positive environments. METHODS: Behavioural and neural measures of response inhibition were assessed during a Stop-signal task in participants with (N = 197) and without (N = 295) ADHD, from N = 278 families (age M = 17...
May 12, 2016: World Journal of Biological Psychiatry
Alberto Fernández-Jaén, Jacobo Albert, Daniel Martín Fernández-Mayoralas, Sara López-Martín, Ana Laura Fernández-Perrone, Mar Jimenez de la Peña, Beatriz Calleja-Pérez, Manuel Recio Rodríguez, Sonia López Arribas
OBJECTIVE: This study aimed to examine the influence of dopamine transporter gene (DAT1) 3'UTR genotype on cingulate cortical thickness in a large sample of children and adolescents with ADHD. METHOD: Brain MRIs were acquired from 46 ADHD patients with homozygosity for the 10-repeat allele and 52 ADHD patients with a single copy or no copy of the allele. The cingulate cortex of each MRI scan was automatically parceled into sulci and gyri as well as into Brodmann areas (BA)...
May 9, 2016: Journal of Attention Disorders
Eyup Sabri Ercan, Serkan Suren, Ali Bacanlı, Kemal Utku Yazıcı, Cem Callı, Ulku Akyol Ardic, Duygu Aygunes, Buket Kosova, Onur Ozyurt, Cahide Aydın, Luis Augusto Rohde
This study aimed to provide novel insights into the white matter (WM) microstructural properties of Attention Deficit/Hyperactivity Disorder (ADHD) subtypes by recruiting a relatively large sample of stimulant-naïve children and adolescents who had no comorbidity other than Oppositional Defiant Disorder and were homogenous according to the DAT1 gene polymorphism. A sample of 72 ADHD subjects and 24 controls aged 8-15 years were enrolled in the study. We applied tract-based spatial statistics to the DTI measures for obtaining fractional anisotropy (FA) and axial, radial diffusivity (AD, RD) measures to explore ADHD type-related differences in WM for the whole brain...
April 14, 2016: Psychiatry Research
A N Inci Kenar, G A Ünal, H Güler, B Albuz, Y Kıroğlu, M E Erdal, H Herken
OBJECTIVE: This study investigated the relationship between DAT1 gene polymorphisms and the effects of methylphenidate (MPH) administration on N-acetyl aspartate (NAA), creatine (Cr), and choline (Cho) levels in the anterior cingulate cortex, prefrontal cortex, striatum, and cerebellum in adult patients with attention deficit hyperactivity disorder (ADHD). This was the first study to investigate the relationship between DAT gene variable number tandem repeat (VNTR) polymorphisms and the responses of brain metabolites to MPH...
April 2016: European Review for Medical and Pharmacological Sciences
E Van Assche, T Moons, K Van Leeuwen, H Colpin, K Verschueren, W Van Den Noortgate, L Goossens, S Claes
BACKGROUND: Parenting dimensions are associated with depressive symptoms in adolescents. We investigated the role of perceived parenting dimensions and gene-environment interactions between these perceived parenting dimensions and five well-known variable number of tandem repeats (VNTRs): 5-HTTLPR, STin2, DAT1, DRD4, and MAO-A, in depressive symptoms. METHODS: From a non-clinical sample of 1111 Belgian adolescents (mean age: 13.79 years, SD=.94; 51% boys), 1103 adolescents consented for genetic research...
May 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
Julia Kraemmer, Kara Smith, Daniel Weintraub, Vincent Guillemot, Mike A Nalls, Florence Cormier-Dequaire, Ivan Moszer, Alexis Brice, Andrew B Singleton, Jean-Christophe Corvol
OBJECTIVES: Impulse control disorders (ICD) are commonly associated with dopamine replacement therapy (DRT) in patients with Parkinson's disease (PD). Our aims were to estimate ICD heritability and to predict ICD by a candidate genetic multivariable panel in patients with PD. METHODS: Data from de novo patients with PD, drug-naïve and free of ICD behaviour at baseline, were obtained from the Parkinson's Progression Markers Initiative cohort. Incident ICD behaviour was defined as positive score on the Questionnaire for Impulsive-Compulsive Disorders in PD...
October 2016: Journal of Neurology, Neurosurgery, and Psychiatry
C-J Yu, J-C Du, H-C Chiou, M-Y Chung, W Yang, Y-S Chen, M-R Fuh, L-C Chien, B Hwang, M-L Chen
Attention-deficit/hyperactivity disorder (ADHD) is male predominated, and the etiology of this disorder remains unclear. Past studies have assessed the association of low-level organophosphate pesticide exposure with childhood ADHD cross-sectionally and prospectively. However, the results have been inconsistent. A first case-control study was performed to investigate the relationship between organophosphate pesticide exposure and ADHD with adjusted covariates. We recruited 97 doctor-diagnosed ADHD cases and 110 non-ADHD controls who were 4-15 years of age...
July 2016: Andrology
Asher Ornoy, Victoria Finkel-Pekarsky, Einat Peles, Miriam Adelson, Shaul Schreiber, P Richard Ebstein
BACKGROUND: Polymorphisms in genes such as DAT1, 5HTTLPR, D4DR4, and MAO-A have been linked to attention deficit hyperactivity disorder (ADHD) and susceptibility for opiate addiction. We investigated in opiate-addicted parents and their children the rate of ADHD and genetic markers that could predict susceptibility to ADHD and/or opiate addiction. METHODS: We studied 64 heroin-addicted, methadone-maintained parents, and their 94 children who had or had not been exposed prenatally to opiates...
August 2016: Pediatric Research
Jaclyn M Kamradt, Joel T Nigg, Karen H Friderici, Molly A Nikolas
Genetic influences on dopaminergic neurotransmission have been implicated in attention-deficit hyperactivity disorder (ADHD) and are theorized to impact cognitive functioning via alterations in frontal-striatal circuitry. Neuropsychological functioning has been proposed to account for the potential associations between dopamine candidate genes and ADHD. However, to date, this mediation hypothesis has not been directly tested. Participants were 498 youth ages 6-17 years (mean M = 10.8 years, SD = 2.4 years, 55...
April 6, 2016: Development and Psychopathology
J S Richards, A Arias Vásquez, D von Rhein, D van der Meer, B Franke, P J Hoekstra, D J Heslenfeld, J Oosterlaan, S V Faraone, J K Buitelaar, C A Hartman
Little is known about the causes of individual differences in reward sensitivity. We investigated gene-environment interactions (GxE) on behavioral and neural measures of reward sensitivity, in light of the differential susceptibility theory. This theory states that individuals carrying plasticity gene variants will be more disadvantaged in negative, but more advantaged in positive environments. Reward responses were assessed during a monetary incentive delay task in 178 participants with and 265 without attention-deficit/hyperactivity disorder (ADHD), from N=261 families...
2016: Translational Psychiatry
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