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https://www.readbyqxmd.com/read/29684537/genetic-imaging-study-with-tc-99m-trodat-1-spect-in-adolescents-with-adhd-using-oros-methylphenidate
#1
Aynur Pekcanlar Akay, Gamze Çapa Kaya, Samet Kose, Çiğdem Eresen Yazıcıoğlu, Handan Özek Erkuran, Sevay Alşen Güney, Kaya Oğuz, Duygu Keskin, Burak Baykara, Neslihan İnal Emiroğlu, Mine Şencan Eren, Sefa Kızıldağ, Türkan Ertay, Dua Özsoylu, Süha Miral, Hatice Durak, Ali Saffet Gönül, Luis Augusto Rohde
AIM: To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-99m ] TRODAT-1SPECT in a sample of treatment-naïve adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). In addition, to assess whether risk alleles (homozygosity for 10-repeat allele at the DAT1 gene were associated with alterations in striatal DAT availability. METHODS: Twenty adolescents with ADHD underwent brain single-photon emission computed tomography (SPECT) scans with [Tc-99m ] TRODAT-1 at baseline and two months after starting OROS-MPH treatment with dosages up to 1 mg/kg/day...
April 20, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29567584/interaction-between-striatal-volume-and-dat1-polymorphism-predicts-working-memory-development-during-adolescence
#2
F Nemmi, C Nymberg, F Darki, T Banaschewski, A L W Bokde, C Büchel, H Flor, V Frouin, H Garavan, P Gowland, A Heinz, J-L Martinot, F Nees, T Paus, M N Smolka, T W Robbins, G Schumann, T Klingberg
There is considerable inter-individual variability in the rate at which working memory (WM) develops during childhood and adolescence, but the neural and genetic basis for these differences are poorly understood. Dopamine-related genes, striatal activation and morphology have been associated with increased WM capacity after training. Here we tested the hypothesis that these factors would also explain some of the inter-individual differences in the rate of WM development. We measured WM performance in 487 healthy subjects twice: at age 14 and 19...
March 13, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29546858/cloninger-s-temperament-and-character-dimensions-and-dopaminergic-genes-dat1-vntr-and-comt-val158met-polymorphisms
#3
Ivana Glavina Jelaš, Ivan Dević, Dalibor Karlović
BACKGROUND: the objective of this study was to examine the associations between Cloninger temperament and character dimensions with the DAT1 VNTR and COMT Val158Met polymorphisms. SUBJECTS AND METHODS: The study was conducted on 101 subjects, consisting of students of the Police College in Zagreb and staff of the Sestre Milosrdnice University Hospital in Zagreb. The Cloninger Temperament and Character Inventory (TCI) was used to test personality traits. RESULTS: A main effect of the DAT1 VNTR polymorphism was found on the subscale self-directedness - SD2 (F=5...
March 2018: Psychiatria Danubina
https://www.readbyqxmd.com/read/29541062/dat1-genotype-and-menstrual-cycle-but-not-hormonal-contraception-modulate-reinforcement-learning-preliminary-evidence
#4
Kristina Jakob, Hanna Ehrentreich, Sarah K C Holtfrerich, Luise Reimers, Esther K Diekhof
Hormone by genotype interactions have been widely ignored by cognitive neuroscience. Yet, the dependence of cognitive performance on both baseline dopamine (DA) and current 17ß-estradiol (E2) level argues for their combined effect also in the context of reinforcement learning. Here, we assessed how the interaction between the natural rise of E2 in the late follicular phase (FP) and the 40 base-pair variable number tandem repeat polymorphism of the dopamine transporter (DAT1) affects reinforcement learning capacity...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29433615/a-haplotype-of-the-dopamine-transporter-gene-modulates-regional-homogeneity-gray-matter-volume-and-visual-memory-in-children-with-attention-deficit-hyperactivity-disorder
#5
C Y Shang, H Y Lin, W Y Tseng, S S Gau
BACKGROUND: The dopamine transporter gene (DAT1) and visual memory deficits have been consistently reported to be associated with attention-deficit/hyperactivity disorder (ADHD). This study aimed to examine whether a DAT1 haplotype affected functional and structural brain alterations in children with ADHD and whether those alterations were associated with visual memory. METHOD: We recruited a total of 37 drug-naïve children with ADHD (17 with the DAT1 rs27048 (C)/rs429699 (T) haplotype and 20 without the CT haplotype) and 37 typically developing children (17 with the CT haplotype and 20 without the CT haplotype)...
February 13, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29423319/improvement-of-long-term-memory-access-with-a-pro-dopamine-regulator-in-an-elderly-male-are-we-targeting-dopamine-tone
#6
Thomas McLaughlin, David Han, James Nicholson, Bruce Steinberg, Kenneth Blum, Marcelo Febo, Eric Braverman, Mona Li, Lyle Fried, Rajendra Badgaiyan
With aging, there is decline in both short-term and long-term memory. This effect is magnified by epigenetic insults on specific, dopamine- related genes (e.g., DRD2, DAT1) as well as by impaired or reduced mRNA transcription. In addition, long-term memory ability is positively correlated with dopamine function and there is evidence that aging is associated with a reduction in brain dopamine D2 receptors, with an acceleration seen in aging-induced dementia. As a result, the authors tested the acute effect of a Pro-Dopamine Regulator (KB220Z, liquid Nano variant) on an aspect of long-term memory performance in a 77-year-old, highly functional male, using the Animal Naming Test (ANT)...
May 2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/29404409/the-influence-of-dat1-comt-and-bdnf-genetic-polymorphisms-on-total-and-subregional-hippocampal-volumes-in-early-onset-heavy-cannabis-users
#7
Albert Batalla, Valentina Lorenzetti, Yann Chye, Murat Yücel, Carles Soriano-Mas, Sagnik Bhattacharyya, Marta Torrens, José A S Crippa, Rocío Martín-Santos
Introduction: Hippocampal neuroanatomy is affected by genetic variations in dopaminergic candidate genes and environmental insults, such as early onset of chronic cannabis exposure. Here, we examine how hippocampal total and subregional volumes are affected by cannabis use and functional polymorphisms of dopamine-relevant genes, including the catechol-O-methyltransferase (COMT), dopamine transporter (DAT1), and the brain-derived neurotrophic factor (BDNF) genes. Material and Methods: We manually traced total hippocampal volumes and automatically segmented hippocampal subregions using high-resolution MRI images, and performed COMT, DAT1, and BDNF genotyping in 59 male Caucasian young adults aged 18-30 years...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29362512/dopaminergic-genetic-variation-influences-aripiprazole-effects-on-alcohol-self-administration-and-the-neural-response-to-alcohol-cues-in-a-randomized-trial
#8
Joseph P Schacht, Konstantin E Voronin, Patrick K Randall, Raymond F Anton
Dopamine (DA) signaling regulates many aspects of Alcohol Use Disorder (AUD). However, clinical studies of dopaminergic medications, including the DA partial agonist aripiprazole (APZ), have been inconsistent, suggesting the possibility of a pharmacogenetic interaction. This study examined whether variation in DA-related genes moderated APZ effects on reward-related AUD phenotypes. The interacting effects of APZ and a variable number tandem repeat (VNTR) polymorphism in DAT1/SLC6A3 (the gene encoding the DA transporter (DAT)) were tested...
May 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29332099/association-between-the-intron-8-vntr-polymorphism-of-the-dat1-gene-and-crack-cocaine-addiction
#9
Anderson R Stolf, Diana Müller, Jaqueline B Schuch, Gláucia C Akutagava-Martins, Luciano S P Guimaraes, Claudia M Szobot, Ricardo Halpern, Felix H P Kessler, Flavio Pechansky, Tatiana Roman
BACKGROUND: This study aims to compare allele and genotype frequencies of a 30-bp variable number of tandem repeats (VNTR) polymorphism of the DAT1 gene, located at intron 8, between adult crack cocaine users and nonaddicted individuals. Due to its involvement in drug addiction, this gene is a good candidate for molecular studies. METHODS: A cross-sectional sample of 239 current adult crack abusers or dependents from in- and outpatient clinics and 211 control individuals was collected in Brazil...
2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29325450/symptom-science-omics-supports-common-biological-underpinnings-across-symptoms
#10
Maura K McCall, Ansley Grimes Stanfill, Elizabeth Skrovanek, Jessica Renee Pforr, Susan W Wesmiller, Yvette P Conley
For precision health care to be successful, an in-depth understanding of the biological mechanisms for symptom development and severity is essential. Omics-based research approaches facilitate identification of the biological underpinnings of symptoms. We reviewed literature for omics-based approaches and exemplar symptoms (sleep disruption, cognitive impairment, fatigue, gastrointestinal [GI] distress, and pain) to identify genes associated with the symptom or symptoms across disease processes. The review yielded 27 genes associated with more than one symptom...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29294665/the-interaction-of-dopamine-genes-and-financial-stressors-to-predict-adulthood-intimate-partner-violence-perpetration
#11
Laura M Schwab-Reese, Edith A Parker, Corinne Peek-Asa
Three dopamine genes (DAT1, DRD2, and DRD4) have been associated with interpersonal delinquency, aggression, and violence when individuals experience adverse environmental exposures. Guided by the catalyst model of aggression, risk alleles identified in previous studies were hypothesized to be associated with intimate partner violence (IPV) perpetration in the presence of financial stressors, a possible environmental trigger. This hypothesis was tested using weighted, clustered logistic regression with data from the National Longitudinal Study of Adolescent to Adult Health...
March 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29240779/impact-of-maternal-high-fat-diet-on-hypothalamic-transcriptome-in-neonatal-sprague-dawley-rats
#12
Sanna Barrand, Tamsyn M Crowley, Ryan J Wood-Bradley, Kirstie A De Jong, James A Armitage
Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to imbalances in appetite and energy homeostasis and increasing the risk of obesity in subsequent generations. Early in postnatal life, the neuronal projections responsible for energy homeostasis develop in response to appetite-related peptides such as leptin. To date, no study characterises the genome-wide transcriptional changes that occur in response to exposure to high fat diet during this critical window...
2017: PloS One
https://www.readbyqxmd.com/read/29135816/dopaminergic-genetic-variants-and-voluntary-externally-paced-exercise-behavior
#13
Denise J VAN DER Mee, Iryna O Fedko, Jouke-Jan Hottenga, Erik A Ehli, Matthijs D VAN DER Zee, Lannie Ligthart, Toos C E M VAN Beijsterveldt, Gareth E Davies, Meike Bartels, Joseph G Landers, Eco J C DE Geus
PURPOSE: Most candidate gene studies on the neurobiology of voluntary exercise behavior have focused on the dopaminergic signaling pathway and its role in the mesolimbic reward system. We hypothesized that dopaminergic candidate genes may influence exercise behavior through additional effects on executive functioning and that these effects are only detected when the types of exercise activity are taken into account. METHODS: Data on voluntary exercise behavior and at least one single-nucleotide polymorphism/variable number of tandem repeat (VNTR) were available for 12,929 participants of the Netherlands Twin Registry...
April 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29122229/-study-of-genetic-variants-in-the-bdnf-comt-dat1-and-sert-genes-in-colombian-children-with-attention-deficit-disorder
#14
Jenny Ortega-Rojas, Carlos E Arboleda-Bustos, Luis Morales, Bruno A Benítez, Diana Beltrán, Álvaro Izquierdo, Humberto Arboleda, Rafael Vásquez
BACKGROUND: Attention deficit and hyperactive disorder (ADHD) is highly prevalent among children in Bogota City. Both genetic and environmental factors play a very important role in the etiology of ADHD. However, to date few studies have addressed the association of genetic variants and ADHD in the Colombian population. OBJECTIVES: To test the genetic association between polymorphisms in the DAT1, HTTLPR, COMT and BDNF genes and ADHD in a sample from Bogota City...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29071281/evaluation-of-vntr-polymorphisms-of-dopamine-transporter-gene-and-the-risk-of-bipolar-disorder-in-zahedan-southeast-iran
#15
Mansour Shakiba, Mohammad Hashemi, Salah Mahdar, Zahra Rahbari, Gholamreza Bahari
The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type 1 (BD) in a sample of Iranian population. This case-control study was performed on 152 BD patients and 153 psychiatrically healthy subjects. Genotyping of the variant was done by polymerase chain reaction method...
September 2017: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/29061424/dopamine-transporter-gene-polymorphism-in-children-with-adhd-a-pilot-study-in-indonesian-samples
#16
Tjhin Wiguna, Raden Irawati Ismail, Noorhana Setyawati Winarsih, Fransiska Kaligis, Anggia Hapsari, Lina Budiyanti, Rini Sekartini, Susan Rahayu, Anthony P S Guerrero
INTRODUCTION: Several studies showed that DAT1 polymorphism closed related with ADHD although the results were not consistently found. Studies in China, South Korea, Japan revealed that 10-repeat allele gave a risk for ADHD. Based on that understanding, this study tried to identify whether the similar polymorphism of DAT1 was also apparent in Indonesian children with ADHD. METHOD: This was a case - control study. Case was 50 Indonesian origin children with ADHD and without any other mental disorders and metal retardation...
October 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29038017/fetal-growth-interacts-with-multilocus-genetic-score-reflecting-dopamine-signaling-capacity-to-predict-spontaneous-sugar-intake-in%C3%A2-children
#17
Patrícia P Silveira, Irina Pokhvisneva, Hélène Gaudreau, Leslie Atkinson, Alison S Fleming, Marla B Sokolowski, Meir Steiner, James L Kennedy, Laurette Dubé, Robert D Levitan, Michael J Meaney
BACKGROUND: We have shown that intrauterine growth restriction (IUGR) leads to increased preference for palatable foods at different ages in both humans and rodents. In IUGR rodents, altered striatal dopamine signaling associates with a preference for palatable foods. OBJECTIVES: Our aim was to investigate if a multilocus genetic score reflecting dopamine-signaling capacity is differently associated with spontaneous palatable food intake in children according to the fetal growth status...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/29029252/time-on-task-effect-during-sleep-deprivation-in-healthy-young-adults-is-modulated-by-dopamine-transporter-genotype
#18
Brieann C Satterfield, Jonathan P Wisor, Michelle A Schmidt, Hans P A Van Dongen
Study Objectives: The time-on-task (TOT) effect and total sleep deprivation (TSD) have similar effects on neurobehavioral functioning, including increased performance instability during tasks requiring sustained attention. The TOT effect is exacerbated by TSD, suggesting potentially overlapping mechanisms. We probed these mechanisms by investigating genotype-phenotype relationships on psychomotor vigilance test (PVT) performance for 3 a-priori selected genes previously linked to the TOT effect and/or TSD: dopamine active transporter 1 (DAT1), catechol-O-methyltransferase (COMT), and tumor necrosis factor alpha (TNFα)...
December 1, 2017: Sleep
https://www.readbyqxmd.com/read/28876518/externalizing-problem-behavior-in-adolescence-parenting-interacting-with-dat1-and-drd4-genes
#19
Annelies Janssens, Wim Van Den Noortgate, Luc Goossens, Hilde Colpin, Karine Verschueren, Stephan Claes, Karla Van Leeuwen
This study extends previous gene-by-environment (G × E) research through design and methodological advances and examines alternative hypotheses of diathesis stress, vantage sensitivity, and differential susceptibility. In a sample of 984 adolescents and their parents, we examined whether effects of parental support, proactive, punitive, harsh punitive, and psychological control on externalizing problem behavior are moderated by adolescents' genotype for the dopamine transporter (DAT1) or receptor D4 (DRD4) gene...
June 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28860780/association-between-comt-val158met-and-dat1-polymorphisms-and-depressive-symptoms-in-the-obese-population
#20
Maciej Bieliński, Marcin Jaracz, Natalia Lesiewska, Marta Tomaszewska, Marcin Sikora, Roman Junik, Anna Kamińska, Andrzej Tretyn, Alina Borkowska
OBJECTIVES: Depressive symptoms are common among patients with obesity. Abnormalities in dopamine signaling involved in the reward circuit may ensue excessive consumption of food, resulting in obesity and leading to neuropsychiatric disorders such as depression. This study sought to investigate the association of polymorphisms in the genes encoding DAT1/SLC6A3 and COMT with the intensity of depressive symptoms in obese subjects. PARTICIPANTS AND METHODS: Prevalence and severity of depressive symptoms were assessed in a group of 364 obese patients using the Beck Depression Inventory (BDI) and the Hamilton Depression Rating Scale (HDRS)...
2017: Neuropsychiatric Disease and Treatment
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