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https://www.readbyqxmd.com/read/29135816/dopaminergic-genetic-variants-and-voluntary-externally-paced-exercise-behavior
#1
Denise J van der Mee, Iryna O Fedko, Jouke-Jan Hottenga, Erik A Ehli, Matthijs D van der Zee, Lannie Ligthart, Toos C E M van Beijsterveldt, Gareth E Davies, Meike Bartels, Joseph G Landers, Eco J C de Geus
PURPOSE: Most candidate gene studies on the neurobiology of voluntary exercise behavior have focused on the dopaminergic signaling pathway and its role in the mesolimbic reward system. We hypothesized that dopaminergic candidate genes may influence exercise behavior through additional effects on executive functioning and that these effects are only detected when the types of exercise activity are taken into account. METHODS: Data on voluntary exercise behavior and at least one SNP/VNTR were available for 12,929 participants of the Netherlands Twin Registry...
November 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29122229/-study-of-genetic-variants-in-the-bdnf-comt-dat1-and-sert-genes-in-colombian-children-with-attention-deficit-disorder
#2
Jenny Ortega-Rojas, Carlos E Arboleda-Bustos, Luis Morales, Bruno A Benítez, Diana Beltrán, Álvaro Izquierdo, Humberto Arboleda, Rafael Vásquez
BACKGROUND: Attention deficit and hyperactive disorder (ADHD) is highly prevalent among children in Bogota City. Both genetic and environmental factors play a very important role in the etiology of ADHD. However, to date few studies have addressed the association of genetic variants and ADHD in the Colombian population. OBJECTIVES: To test the genetic association between polymorphisms in the DAT1, HTTLPR, COMT and BDNF genes and ADHD in a sample from Bogota City...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29071281/evaluation-of-vntr-polymorphisms-of-dopamine-transporter-gene-and-the-risk-of-bipolar-disorder-in-zahedan-southeast-iran
#3
Mansour Shakiba, Mohammad Hashemi, Salah Mahdar, Zahra Rahbari, Gholamreza Bahari
The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type 1 (BD) in a sample of Iranian population. This case-control study was performed on 152 BD patients and 153 psychiatrically healthy subjects. Genotyping of the variant was done by polymerase chain reaction method...
September 2017: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/29061424/dopamine-transporter-gene-polymorphism-in-children-with-adhd-a-pilot-study-in-indonesian-samples
#4
Tjhin Wiguna, Raden Irawati Ismail, Noorhana Setyawati Winarsih, Fransiska Kaligis, Anggia Hapsari, Lina Budiyanti, Rini Sekartini, Susan Rahayu, Anthony P S Guerrero
INTRODUCTION: Several studies showed that DAT1 polymorphism closed related with ADHD although the results were not consistently found. Studies in China, South Korea, Japan revealed that 10-repeat allele gave a risk for ADHD. Based on that understanding, this study tried to identify whether the similar polymorphism of DAT1 was also apparent in Indonesian children with ADHD. METHOD: This was a case - control study. Case was 50 Indonesian origin children with ADHD and without any other mental disorders and metal retardation...
October 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29038017/fetal-growth-interacts-with-multilocus-genetic-score-reflecting-dopamine-signaling-capacity-to-predict-spontaneous-sugar-intake-in%C3%A2-children
#5
Patrícia P Silveira, Irina Pokhvisneva, Hélène Gaudreau, Leslie Atkinson, Alison S Fleming, Marla B Sokolowski, Meir Steiner, James L Kennedy, Laurette Dubé, Robert D Levitan, Michael J Meaney
BACKGROUND: We have shown that intrauterine growth restriction (IUGR) leads to increased preference for palatable foods at different ages in both humans and rodents. In IUGR rodents, altered striatal dopamine signaling associates with a preference for palatable foods. OBJECTIVES: Our aim was to investigate if a multilocus genetic score reflecting dopamine-signaling capacity is differently associated with spontaneous palatable food intake in children according to the fetal growth status...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/29029252/time-on-task-effect-during-sleep-deprivation-in-healthy-young-adults-is-modulated-by-dopamine-transporter-genotype
#6
Brieann C Satterfield, Jonathan P Wisor, Michelle A Schmidt, Hans P A Van Dongen
Study Objectives: The time-on-task (TOT) effect and total sleep deprivation (TSD) have similar effects on neurobehavioral functioning, including increased performance instability during tasks requiring sustained attention. The TOT effect is exacerbated by TSD, suggesting potentially overlapping mechanisms. We probed these mechanisms by investigating genotype-phenotype relationships on psychomotor vigilance test (PVT) performance for three a-priori selected genes previously linked to the TOT effect and/or TSD: DAT1, COMT, and TNFα...
October 4, 2017: Sleep
https://www.readbyqxmd.com/read/28876518/externalizing-problem-behavior-in-adolescence-parenting-interacting-with-dat1-and-drd4-genes
#7
Annelies Janssens, Wim Van Den Noortgate, Luc Goossens, Hilde Colpin, Karine Verschueren, Stephan Claes, Karla Van Leeuwen
This study extends previous gene-by-environment (G × E) research through design and methodological advances and examines alternative hypotheses of diathesis stress, vantage sensitivity, and differential susceptibility. In a sample of 984 adolescents and their parents, we examined whether effects of parental support, proactive, punitive, harsh punitive, and psychological control on externalizing problem behavior are moderated by adolescents' genotype for the dopamine transporter (DAT1) or receptor D4 (DRD4) gene...
June 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28860780/association-between-comt-val158met-and-dat1-polymorphisms-and-depressive-symptoms-in-the-obese-population
#8
Maciej Bieliński, Marcin Jaracz, Natalia Lesiewska, Marta Tomaszewska, Marcin Sikora, Roman Junik, Anna Kamińska, Andrzej Tretyn, Alina Borkowska
OBJECTIVES: Depressive symptoms are common among patients with obesity. Abnormalities in dopamine signaling involved in the reward circuit may ensue excessive consumption of food, resulting in obesity and leading to neuropsychiatric disorders such as depression. This study sought to investigate the association of polymorphisms in the genes encoding DAT1/SLC6A3 and COMT with the intensity of depressive symptoms in obese subjects. PARTICIPANTS AND METHODS: Prevalence and severity of depressive symptoms were assessed in a group of 364 obese patients using the Beck Depression Inventory (BDI) and the Hamilton Depression Rating Scale (HDRS)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28833035/prenatal-programming-of-postnatal-plasticity-for-externalizing-behavior-testing-an-integrated-developmental-model-of-genetic-and-temperamental-sensitivity-to-the-environment
#9
Irene Tung, Julia E Morgan, Amanda N Noroña, Steve S Lee
Although both gene- and temperament-environment interactions contribute to the development of youth externalizing problems, it is unclear how these factors jointly affect environmental sensitivity over time. In a 7-year longitudinal study of 232 children (aged 5-10) with and without ADHD, we employed moderated mediation to test a developmentally sensitive mechanistic model of genetic and temperamental sensitivity to prenatal and postnatal environmental factors. Birth weight, a global measure of the prenatal environment, moderated predictions of child negative emotionality from a composite of dopaminergic polymorphisms (i...
December 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28757070/individual-differences-in-the-processing-of-smoking-cessation-video-messages-an-imaging-genetics-study
#10
Zhenhao Shi, An-Li Wang, Catherine A Aronowitz, Daniel Romer, Daniel D Langleben
Studies testing the benefits of enriching smoking-cessation video ads with attention-grabbing sensory features have yielded variable results. Dopamine transporter gene (DAT1) has been implicated in attention deficits. We hypothesized that DAT1 polymorphism is partially responsible for this variability. Using functional magnetic resonance imaging, we examined brain responses to videos high or low in attention-grabbing features, indexed by "message sensation value" (MSV), in 53 smokers genotyped for DAT1. Compared to other smokers, 10/10 homozygotes showed greater neural response to High- vs...
September 2017: Biological Psychology
https://www.readbyqxmd.com/read/28691317/synthesis-and-characterization-of-a-novel-microporous-dihydroxyl-functionalized-triptycene-diamine-based-polyimide-for-natural-gas-membrane-separation
#11
Nasser Alaslai, Xiaohua Ma, Bader Ghanem, Yingge Wang, Fahd Alghunaimi, Ingo Pinnau
An intrinsically microporous polyimide is synthesized in m-cresol by a one-pot high-temperature condensation reaction of 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and newly designed 2,6 (7)-dihydroxy-3,7(6)-diaminotriptycene (DAT1-OH). The 6FDA-DAT1-OH polyimide is thermally stable up to 440 °C, shows excellent solubility in polar solvents, and has moderately high Brunauer-Teller-Emmett (BET) surface area of 160 m(2) g(-1) , as determined by nitrogen adsorption at -196 °C. Hydroxyl functionalization applied to the rigid 3D triptycene-based diamine building block results in a polyimide that exhibits moderate pure-gas CO2 permeability of 70 Barrer combined with high CO2 /CH4 selectivity of 50...
July 10, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28675949/comt-and-dat1-polymorphisms-moderate-the-indirect-effect-of-parenting-behavior-on-youth-adhd-symptoms-through-neurocognitive-functioning
#12
Julia E Morgan, Barbara Caplan, Irene Tung, Amanda N Noroña, Bruce L Baker, Steve S Lee
Although gene × environment interactions contribute to youth attention-deficit/hyperactivity disorder (ADHD) symptoms, the pathways mediating these influences are unknown. We tested genetic moderation of indirect effects from parenting behavior to youth ADHD symptoms through multiple neurocognitive factors. Two hundred and twenty-nine youth with and without ADHD were assessed at baseline (Wave 1; ages 5-10) and at a 2-year follow-up (Wave 2; ages 7-13). At Wave 1, youth completed a neurocognitive battery including measures of response inhibition, visuospatial working memory, and fluid reasoning, and a standardized parent-child interaction task yielding observational measures of positive and negative parenting...
July 4, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28666839/dopamine-transporter-dat1-slc6a3-polymorphism-and-the-association-between-being-born-small-for-gestational-age-and-symptoms-of-adhd
#13
K E Waldie, C M Cornforth, R E Webb, J M D Thompson, R Murphy, D Moreau, R Slykerman, A R Morgan, L R Ferguson, E A Mitchell
Being small for gestational age (SGA) has been established as a risk factor for Attention Deficit Hyperactivity Disorder (ADHD). Likewise, several molecular genetic studies have found a link between DAT1 and ADHD. This study investigated whether SGA moderates the effect of dopamine transporter gene variants on the risk of ADHD. A total of 546 children of European descent were genotyped at age 11 for seven DAT1 SNPs (rs6347, rs11564774, rs40184, rs1042098, rs2702, rs8179029 and rs3863145). The Strengths and Difficulties Questionnaire was used to measure symptoms of ADHD at ages 3...
June 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28616427/specific-genes-associated-with-adverse-events-of-methylphenidate-use-in-the-pediatric-population-a-systematic-literature-review
#14
REVIEW
Beinta Joensen, Morten Meyer, Lise Aagaard
The aim of this study was to review empirical studies examining associations between candidate genes and adverse events (AEs) from methylphenidate (MPH) use in children and adolescents. The PubMed, EMBASE, CINAHL, and Web of Science databases were searched from their inception until March 2017. We included empirically based articles on pharmacogenetic studies in 0-17-year-old patients that investigated associations between specific candidate genes, their polymorphisms, and reported AEs. We extracted information about study design, setting, type of AE reporter, studied genes and their polymorphisms, age and gender, administered doses, method of genotyping, outcome measures, and main findings...
April 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28505190/dynamic-interaction-between-fetal-adversity-and-a-genetic-score-reflecting-dopamine-function-on-developmental-outcomes-at-36-months
#15
Adrianne R Bischoff, Irina Pokhvisneva, Étienne Léger, Hélène Gaudreau, Meir Steiner, James L Kennedy, Kieran J O'Donnell, Josie Diorio, Michael J Meaney, Patrícia P Silveira
BACKGROUND: Fetal adversity, evidenced by poor fetal growth for instance, is associated with increased risk for several diseases later in life. Classical cut-offs to characterize small (SGA) and large for gestational age (LGA) newborns are used to define long term vulnerability. We aimed at exploring the possible dynamism of different birth weight cut-offs in defining vulnerability in developmental outcomes (through the Bayley Scales of Infant and Toddler Development), using the example of a gene vs...
2017: PloS One
https://www.readbyqxmd.com/read/28493018/emerging-role-of-mirna-in-attention-deficit-hyperactivity-disorder-a-systematic-review
#16
REVIEW
Saurabh Srivastav, Susanne Walitza, Edna Grünblatt
Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder whose aetiology still remains elusive. Nevertheless, evidence supports a high genetic contribution that interacts with environmental factors, also known to modulate epigenetic processes. These epigenetic modulators are a class of non-coding RNAs, microRNAs (miRNAs), known as post-transcriptional regulators, which have emerged as prospective players in neuropsychiatric disorders since they play a role in brain development, synapse formation, and the fine-tuning of genes underlying synaptic and memory formation...
May 10, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28428702/drd4-and-dat1-vntr-genotyping-in-children-with-attention-deficit-hyperactivity-disorder
#17
Ashley Stanley, K Chavda, A Subramanian, S V Prabhu, T F Ashavaid
The dopamine receptor-D4 and the dopamine transporter have been investigated for their role in attention deficit hyperactivity disorder (ADHD) in children. Reports of their genetic association with ADHD have shown mixed results. The aim of the study was to evaluate the association of variable number tandem repeats (VNTRs) of the DRD4 and DAT1 genes with ADHD in children. A pilot 1:1 case control study, with 44 clinically confirmed ADHD cases and 44 age/gender matched healthy controls, was conducted at a tertiary care centre in Mumbai...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28393838/functional-polymorphisms-in-dopaminergic-genes-modulate-neurobehavioral-and-neurophysiological-consequences-of-sleep-deprivation
#18
Sebastian C Holst, Thomas Müller, Amandine Valomon, Britta Seebauer, Wolfgang Berger, Hans-Peter Landolt
Sleep deprivation impairs cognitive performance and reliably alters brain activation in wakefulness and sleep. Nevertheless, the molecular regulators of prolonged wakefulness remain poorly understood. Evidence from genetic, behavioral, pharmacologic and imaging studies suggest that dopaminergic signaling contributes to the behavioral and electroencephalographic (EEG) consequences of sleep loss, although direct human evidence thereof is missing. We tested whether dopamine neurotransmission regulate sustained attention and evolution of EEG power during prolonged wakefulness...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376280/independent-and-interactive-effects-of-oprm1-and-dat1-polymorphisms-on-alcohol-consumption-and-subjective-responses-in-social-drinkers
#19
Elise M Weerts, Gary S Wand, Brion Maher, Xiaoqiang Xu, Mary Ann Stephens, Xiaoju Yang, Mary E McCaul
BACKGROUND: The current study examined independent and interactive effects of polymorphisms of the mu opioid receptor gene (OPRM1, A118G) and variable number tandem repeats of the dopamine transporter gene (DAT1, SLC6A3) on alcohol consumption and subjective responses to alcohol in 127 young, healthy, social drinkers. METHODS: Participants completed an in-person assessment, which included self-reported alcohol drinking patterns and blood sampling for DNA, and in a second visit, a cumulative alcohol dosing procedure with subjective ratings across multiple time points and breath alcohol contents (0...
June 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28337537/is-prepulse-modification-altered-by-continuous-theta-burst-stimulation-dat1-genotype-and-motor-threshold-interact-on-prepulse-modification-following-brain-stimulation
#20
S Notzon, N Vennewald, A Gajewska, A L Klahn, J Diemer, B Winter, I Fohrbeck, V Arolt, P Pauli, K Domschke, P Zwanzger
Previous studies suggest an inhibitory top-down control of the amygdala by the prefrontal cortex (PFC). Both brain regions play a role in the modulation of prepulse modification (PPM) of the acoustic startle response by a pre-stimulus. Repetitive transcranial magnetic stimulation (rTMS) can modulate the activity of the PFC and might thus affect PPM. This study tested the effect of inhibitory rTMS on PPM accounting for a genetic variant of the dopamine transporter gene (DAT1). Healthy participants (N = 102) were stimulated with continuous theta burst stimulation (cTBS, an intense form of inhibitory rTMS) or sham treatment over the right PFC...
December 2017: European Archives of Psychiatry and Clinical Neuroscience
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