Aurora Arrue, Olga Olivas, Leire Erkoreka, Francisco Jose Alvarez, Ainara Arnaiz, Noemi Varela, Ainhoa Bilbao, Jose-Julio Rodríguez, María Teresa Moreno-Calle, Estibaliz Gordo, Elena Marín, Javier Garcia-Cano, Estela Saez, Miguel Ángel Gonzalez-Torres, Mercedes Zumárraga, Nieves Basterreche
Treatment with second-generation antipsychotics (SGAs) can cause obesity and other cardiometabolic disorders linked to D2 receptor (DRD2) and to genotypes affecting dopaminergic (DA) activity, within reward circuits. We explored the relationship of cardiometabolic alterations with single genetic polymorphisms DRD2 rs1799732 (NG_008841.1:g.4750dup -> C), DRD2 rs6277 (NG_008841.1:g.67543C>T), COMT rs4680 (NG_011526.1:g.27009G>A), and VNTR in both DRD4 NC_000011.10 (637269-640706) and DAT1 NC_000005.10 (1392794-1445440), as well as with a multilocus genetic profile score (MLGP)...
August 14, 2023: Pharmaceutics